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MCID: CMB002
MIFTS: 38

Combat Disorder

Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Combat Disorder

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MalaCards integrated aliases for Combat Disorder:

Name: Combat Disorder 12 15
Combat Disorders 43 71
Combat Neurosis 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6950
MeSH 43 D003130
UMLS 71 C0009426
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Summaries for Combat Disorder

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Disease Ontology : 12 An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress.

MalaCards based summary : Combat Disorder, also known as combat disorders, is related to acute stress disorder and neurotic disorder. An important gene associated with Combat Disorder is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Tramadol and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Combat Disorder

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Diseases related to Combat Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 acute stress disorder 30.1 WARS1 SERPINA3 NENF
2 neurotic disorder 10.4
3 prosthetic joint infection 10.2 TLR4 TLR2
4 mycobacterium abscessus 10.2 TLR2 TLR1
5 ocular toxoplasmosis 10.2 TLR9 TLR5 TLR1
6 legionnaire disease 10.2 TLR5 TLR2 SERPINA3
7 neurofibromatosis, type ii 10.2 TLR2 SERPINA3 ADSL
8 fungal keratitis 10.2 TLR4 TLR2
9 glanders 10.2 WARS1 TLR5 TLR4
10 gout 10.2 TLR4 TLR2 ADSL
11 mucocutaneous leishmaniasis 10.2 TLR9 TLR3 CD8A
12 farmer's lung 10.1 SERPINA3 CD8A
13 metal allergy 10.1 TLR4 CD8A
14 pyelitis 10.1 TLR4 TLR2 SERPINA3
15 gingival disease 10.1 TLR4 TLR2 SERPINA3
16 candidiasis 10.1 TLR4 TLR3 TLR2
17 chlamydia 10.1 TLR9 TLR4 TLR2
18 bubonic plague 10.1 WARS1 TLR4 TLR2
19 chickenpox 10.1 TLR9 TLR3 CD8A
20 neisseria meningitidis infection 10.1 TLR4 TLR2
21 suppurative otitis media 10.1 TLR5 TLR4 TLR2
22 acute pericementitis 10.1 TLR6 TLR2
23 gastrointestinal tularemia 10.1 TLR4 TLR2
24 cutaneous leishmaniasis 10.1 TLR9 TLR4 TLR2
25 meningococcal meningitis 10.1 TLR9 TLR4 TLR2
26 meningitis 10.1 TLR9 TLR4 TLR2
27 bronchopneumonia 10.1 TLR4 SERPINA3 CD8A
28 common cold 10.1 TLR4 TLR3 TLR2
29 spondylarthropathy 10.1 TLR4 TLR2
30 ileitis 10.1 TLR5 TLR4 TLR2
31 bacterial vaginosis 10.0 TLR9 TLR4 TLR2
32 legionellosis 10.0 TLR5 TLR4 TLR2
33 bacterial meningitis 10.0 TLR9 TLR4 TLR2
34 visceral leishmaniasis 10.0 TLR9 TLR4 TLR2
35 neurosyphilis 10.0 TLR6 TLR2 TLR1
36 sebaceous gland disease 10.0 TLR4 TLR2 SERPINA3 ADSL
37 pneumonic tularemia 10.0 TLR4 TLR2 CD8A
38 tularemia 10.0 TLR4 TLR2 CD8A
39 pneumonic plague 10.0 TLR4 TLR2 CD8A
40 juvenile nasopharyngeal angiofibroma 10.0 TLR9 TLR7 TLR3
41 alcoholic hepatitis 10.0 TLR9 TLR4 TLR2
42 cervicitis 10.0 TLR4 TLR2 CD8A
43 irritable bowel syndrome 10.0 TLR9 TLR4 TLR2
44 alveolar echinococcosis 10.0 TLR4 TLR2 CD8A
45 echinococcosis 10.0 TLR4 TLR2 CD8A
46 primary systemic mycosis 10.0 TLR4 TLR2 CD8A
47 fallopian tube disease 10.0 TLR4 TLR2 CD8A
48 listeriosis 10.0 TLR4 TLR2 CD8A
49 acute cystitis 10.0 TLR5 TLR4 TLR2 ADSL
50 colitis 9.9 TLR9 TLR5 TLR4 TLR2

Graphical network of the top 20 diseases related to Combat Disorder:



Diseases related to Combat Disorder
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Symptoms & Phenotypes for Combat Disorder

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MGI Mouse Phenotypes related to Combat Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD8A TLR1 TLR2 TLR3 TLR4 TLR5
2 immune system MP:0005387 9.32 CD8A TLR1 TLR2 TLR3 TLR4 TLR5
Sources

Drugs & Therapeutics for Combat Disorder

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Drugs for Combat Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
4 Neurotransmitter Agents Phase 4
5 Narcotics Phase 4
6 Analgesics, Opioid Phase 4
7 Analgesics Phase 4
8 Serotonin Uptake Inhibitors Phase 4
9 Antipsychotic Agents Phase 4
10 Tranquilizing Agents Phase 4
11 Cytochrome P-450 Enzyme Inhibitors Phase 4
12 Psychotropic Drugs Phase 4
13 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
14 Antidepressive Agents Phase 4
15 Quetiapine Fumarate Phase 4 111974-72-2
16 Serotonin Agents Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
18
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
19
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
20 Hydrocortisone hemisuccinate Phase 2, Phase 3
21 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
22 Omega 3 Fatty Acid Phase 2
23 Antihypertensive Agents Phase 1, Phase 2
24 Adrenergic alpha-Antagonists Phase 1, Phase 2
25 Adrenergic Antagonists Phase 1, Phase 2
26 Adrenergic Agents Phase 1, Phase 2
27
Cycloserine Approved 68-41-7 401 6234
28
Ethanol Approved 64-17-5 702
29 Central Nervous System Depressants
30 Renal Agents
31 Nootropic Agents
32 Antitubercular Agents
33 Antibiotics, Antitubercular
34 Anti-Infective Agents, Urinary
35 Anti-Bacterial Agents
36 Antimetabolites
37 Anti-Infective Agents
38 Anti-Infective Agents, Local

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 A Double-Blind, Placebo-Controlled, Flexible-Dose Pilot Clinical Trial of Once-Daily Extended-Release Tramadol for the Treatment of PTSD Unknown status NCT01517711 Phase 4 Tramadol;Placebo
2 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
3 A Placebo-controlled Trial of Adjunctive Quetiapine for Refractory PTSD Completed NCT00292370 Phase 4 Open Label (OL) Paroxetine;Placebo;Quetiapine
4 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
5 Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms Completed NCT00475241 Phase 2, Phase 3
6 Military to Civilian: RCT of an Intervention to Promote Postdeployment Reintegration Completed NCT00640445 Phase 2, Phase 3
7 Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders: A Mood Resilience Trial Unknown status NCT01216982 Phase 2 Lovaza, omega-3 fatty acid ethyl ester;Placebo, visually identical to Lovaza
8 Trauma Management Therapy for OEF and OIF Combat Veterans Completed NCT02809326 Phase 2
9 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin Recruiting NCT02266329 Phase 1, Phase 2 prazosin hydrochloride;placebo
10 Exercise: A Novel Treatment for Combat PTSD Terminated NCT01626131 Phase 2
11 Phase 2a, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating Efficacy, Safety, and Pharmacokinetics of Orally Administered SNC-102 in Subjects With Combat-Related Posttraumatic Stress Disorder Concomitantly Treated With Prazosin Withdrawn NCT02384369 Phase 2 SNC-102 sustained release tablet
12 Psychotherapy Treatment of Deployment-related PTSD in Primary Care Settings Completed NCT00974402
13 Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder Completed NCT00539279
14 Prospective Study of Functional Status in Veterans at Risk for Unexplained Illnesses Completed NCT00285246
15 A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD Completed NCT00371176 D-Cycloserine
16 Reintegration: The Role of Spouse Telephone BATTLEMIND Pilot Study Completed NCT00870545
17 Exploring Deployment Stress and Reintegration in Army National Guard Chaplains Completed NCT01330888
18 Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups Completed NCT01121250
19 Motivational Interviewing to Engage OEF/OIF Veterans in Mental Health Treatment Completed NCT00419029
20 The Effect of Acupuncture on PTSD-Related Insomnia Completed NCT00868517
21 A Placebo-Controlled Augmentation Trial of Prazosin for PTSD Completed NCT00990106 prazosin hydrochloride;placebo
22 Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With Post Traumatic Stress Disorder (PTSD) Completed NCT01459705
23 Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With PTSD Completed NCT01193725
24 Integrated Treatment of Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Post-traumatic Stress Disorder and Substance Use Disorders Completed NCT01338506
25 Group Cognitive Behavioral Therapy for Anger and Aggression in Veterans With PTSD Completed NCT02233517
26 Prolonged Exposure for PTSD Among OIF/OEF Personnel: Massed vs. Spaced Trials Completed NCT01049516
27 A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel Completed NCT02556645
28 Evaluation of the Impact of Diving Training on Recovery in a Cohort of Veterans Suffering of PTSD: an Exploratory Clinical Control Trial Recruiting NCT03995992
29 TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Recruiting NCT04040387
30 A Remote Randomized Double-Blind Sham-Controlled Clinical Trial of NightWare in Adults With Post-Traumatic Stress Disorder and Co-Morbid Nightmare Disorder Recruiting NCT03934658
31 The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD: A Randomized Controlled Trial in Active Duty Military Personnel Recruiting NCT02720497
32 An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military Active, not recruiting NCT03337750
33 Prospective Evaluation of Health Outcomes in AE Casualties: a Pilot Study Active, not recruiting NCT03736356
34 Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD Active, not recruiting NCT02226367 prazosin hydrochloride;placebo
35 TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Active, not recruiting NCT03795987
36 Vietnam Era Health Retrospective Observational Study Active, not recruiting NCT02825602
37 NightWare Open Enrollment Study Enrolling by invitation NCT03828656
38 FOCUS-CI: A Preventive Intervention With Children and Families of the Combat Injured Terminated NCT01062022
39 Evaluation of a Telepharmacy Robotic Medicine Delivery Unit in Warrior Transition Unit Patients With Traumatic Brain Injury, Post-Traumatic Stress Disorder, or Polytrauma Withdrawn NCT01007006
40 Effect of Prazosin on Neurophysiologic Responses and Cognitive Performance in PTSD Withdrawn NCT00890643 prazosin hydrochloride;placebo

Search NIH Clinical Center for Combat Disorder

Cochrane evidence based reviews: combat disorders

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Genetic Tests for Combat Disorder

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Anatomical Context for Combat Disorder

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MalaCards organs/tissues related to Combat Disorder:

40
Brain, Lung, Bone, Lymph Node, Tonsil
Sources

Publications for Combat Disorder

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Articles related to Combat Disorder:

(show all 17)
# Title Authors PMID Year
1
A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo. 61
30223587 2018
2
Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. 61
30275974 2018
3
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. 61
27125741 2016
4
Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein. 61
26116876 2015
5
[Traumatic psychological combat disorders. Extraordinary experiences]. 61
25975160 2015
6
Nothing new under the sun: post-traumatic stress disorders in the ancient world. 61
25577928 2014
7
Gulf War Syndrome: a review of current knowledge and understanding. 61
25895403 2014
8
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder. 61
23842024 2013
9
Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. 61
21323908 2011
10
Prevalence of chronic pain after traumatic brain injury: a systematic review. 61
18698069 2008
11
Nicotinic receptors containing the alpha7 subunit: a model for rational drug design. 61
19075644 2008
12
[Characteristics of combat disorders in war veterans committed illegal aggressive actions]. 61
17902346 2007
13
Historical approaches to post-combat disorders. 61
16687259 2006
14
Flashbacks and post-traumatic stress disorder: the genesis of a 20th-century diagnosis. 61
12562745 2003
15
Post-combat syndromes from the Boer war to the Gulf war: a cluster analysis of their nature and attribution. 61
11834557 2002
16
Mortality of former prisoners of war and other Australian veterans. 61
1630377 1992
17
Chronic morbidity of former prisoners of war and other Australian veterans. 61
1943902 1991
Sources

Variations for Combat Disorder

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Expression for Combat Disorder

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Search GEO for disease gene expression data for Combat Disorder.
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Pathways for Combat Disorder

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Pathways related to Combat Disorder according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.94 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
2
Activated TLR4 signalling 65
Show member pathways
 13.53 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
3
Akt Signaling 63
Show member pathways
 13.37 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
4
IL-2 Pathway 63
Show member pathways
 13.2 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
5
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.13 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
6
NF-KappaB Family Pathway 63
Show member pathways
 12.75 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
7
Measles 36
Show member pathways
 12.71 TLR9 TLR7 TLR4 TLR3 TLR2
8
TRAF Pathway 63
Show member pathways
 12.63 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
9
NF-kappaB Signaling 4
12.59 TLR9 TLR8 TLR7 TLR6 TLR3 TLR2
10
T cell receptor signaling pathway 36
Show member pathways
 12.45 TLR9 TLR4 TLR2 CD8A
11
VEGF Pathway (Qiagen) 63
Show member pathways
 12.44 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
12
Antigen processing-Cross presentation 65
Show member pathways
 12.4 TLR6 TLR4 TLR2 TLR1 CD8A
13
Bacterial infections in CF airways 22
Show member pathways
 12.28 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
14
Tuberculosis 36
12.19 TLR9 TLR6 TLR4 TLR2 TLR1
15
Th1 Differentiation Pathway 64
Show member pathways
 12.13 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
16
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.98 TLR6 TLR4 TLR2 TLR1
17
MAPK Pathway 70
Show member pathways
 11.95 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
18
Diseases associated with the TLR signaling cascade 65
Show member pathways
 11.93 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
19
Phagocytosis of Microbes 63
11.89 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
20
Dendritic Cells Developmental Lineage Pathway 64
11.64 TLR9 TLR7 CD8A
21
Colorectal Cancer Metastasis 63
11.54 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
22
Legionellosis 36
11.52 TLR5 TLR4 TLR2
23
Malaria 36
11.46 TLR9 TLR4 TLR2
Sources

GO Terms for Combat Disorder

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Cellular components related to Combat Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.18 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
2 integral component of plasma membrane GO:0005887 9.61 TLR6 TLR5 TLR4 TLR3 TLR2 TLR10
3 endosome membrane GO:0010008 9.55 TLR9 TLR8 TLR7 TLR4 TLR3
4 phagocytic vesicle membrane GO:0030670 9.5 TLR6 TLR2 TLR1
5 early phagosome GO:0032009 9.37 TLR9 TLR7
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.26 TLR2 TLR1
7 endolysosome membrane GO:0036020 8.92 TLR9 TLR8 TLR7 TLR3

Biological processes related to Combat Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
2 immune response GO:0006955 10.2 TLR9 TLR8 TLR7 TLR6 TLR4 TLR2
3 innate immune response GO:0045087 10.16 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
4 immune system process GO:0002376 10.14 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
5 positive regulation of gene expression GO:0010628 10.13 WARS1 TLR9 TLR6 TLR4 TLR3 TLR2
6 defense response to bacterium GO:0042742 10.06 TLR9 TLR6 TLR5 TLR4 TLR3
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.03 TLR9 TLR6 TLR4 TLR3 TLR2
8 positive regulation of inflammatory response GO:0050729 10.03 TLR9 TLR7 TLR4 TLR3 TLR2 TLR10
9 defense response to virus GO:0051607 10.01 TLR9 TLR8 TLR7 TLR3
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.01 TLR9 TLR6 TLR4 TLR3
11 cellular response to mechanical stimulus GO:0071260 10 TLR8 TLR7 TLR5 TLR4 TLR3
12 positive regulation of interleukin-6 production GO:0032755 10 TLR9 TLR8 TLR7 TLR4 TLR3 TLR2
13 inflammatory response GO:0006954 10 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
14 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.99 TLR9 TLR8 TLR7 TLR4 TLR3
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.98 TLR9 TLR7 TLR4 TLR3 TLR2
16 microglial cell activation GO:0001774 9.93 TLR8 TLR7 TLR6 TLR3 TLR2
17 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR9 TLR4 TLR3 TLR2
18 cellular response to interferon-gamma GO:0071346 9.91 TLR4 TLR3 TLR2
19 positive regulation of interleukin-12 production GO:0032735 9.91 TLR9 TLR4 TLR3 TLR2
20 positive regulation of interferon-beta production GO:0032728 9.91 TLR9 TLR4 TLR3 TLR2
21 positive regulation of chemokine production GO:0032722 9.91 TLR9 TLR7 TLR4 TLR3 TLR2
22 positive regulation of JNK cascade GO:0046330 9.9 TLR9 TLR4 TLR3
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TLR6 TLR5 TLR4
24 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.88 TLR9 TLR8 TLR7 TLR4
25 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.87 TLR9 TLR8 TLR7 TLR3
26 positive regulation of interleukin-6 secretion GO:2000778 9.86 TLR8 TLR4 TLR2
27 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.86 TLR6 TLR4 TLR3
28 positive regulation of interleukin-8 production GO:0032757 9.85 TLR9 TLR7 TLR5 TLR4 TLR3 TLR2
29 positive regulation of interleukin-10 production GO:0032733 9.83 TLR9 TLR4 TLR2
30 I-kappaB phosphorylation GO:0007252 9.83 TLR9 TLR7 TLR4 TLR3 TLR2
31 toll-like receptor 9 signaling pathway GO:0034162 9.82 TLR9 TLR8 TLR7
32 positive regulation of interleukin-8 secretion GO:2000484 9.82 TLR4 TLR2 TLR1
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.81 TLR9 TLR4 TLR2
34 cell activation GO:0001775 9.81 TLR6 TLR2 TLR1
35 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.8 TLR9 TLR8 TLR7 TLR3
36 positive regulation of toll-like receptor signaling pathway GO:0034123 9.78 TLR9 TLR5 TLR3 TLR2
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.74 TLR6 TLR4
38 necroptotic process GO:0070266 9.74 TLR4 TLR3
39 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.74 TLR4 TLR1
40 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.74 TLR4 TLR3
41 activation of NF-kappaB-inducing kinase activity GO:0007250 9.74 TLR6 TLR3
42 positive regulation of macrophage activation GO:0043032 9.74 TLR6 TLR4
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.73 TLR6 TLR1
44 maintenance of gastrointestinal epithelium GO:0030277 9.73 TLR9 SERPINA3
45 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.73 TLR6 TLR4
46 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.73 TLR6 TLR4
47 response to molecule of bacterial origin GO:0002237 9.73 TLR9 TLR2
48 macrophage activation GO:0042116 9.72 TLR4 TLR1
49 cellular response to lipoteichoic acid GO:0071223 9.72 TLR4 TLR2
50 interleukin-1 beta secretion GO:0050702 9.72 TLR6 TLR4

Molecular functions related to Combat Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.97 TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2 signaling receptor activity GO:0038023 9.63 TLR8 TLR6 TLR4 TLR3 TLR2 TLR1
3 amyloid-beta binding GO:0001540 9.61 TLR6 TLR4 TLR2
4 double-stranded RNA binding GO:0003725 9.58 TLR8 TLR7 TLR3
5 interleukin-1 receptor binding GO:0005149 9.48 TLR9 TLR5
6 siRNA binding GO:0035197 9.46 TLR9 TLR7
7 lipopeptide binding GO:0071723 9.43 TLR6 TLR2 TLR1
8 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
9 Toll-like receptor 2 binding GO:0035663 9.32 TLR6 TLR1
10 transmembrane signaling receptor activity GO:0004888 9.28 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
11 signaling pattern recognition receptor activity GO:0008329 9.26 TLR9 TLR8 TLR7 TLR2
Sources

Sources for Combat Disorder

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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