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MCID: CMB002
MIFTS: 26

Combat Disorder

Categories: Mental diseases, Neuronal diseases
Genes Related diseases Publications Pathways Drugs
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Aliases & Classifications for Combat Disorder

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MalaCards integrated aliases for Combat Disorder:

Name: Combat Disorder 12 15
Combat Disorders 45 74
Combat Neurosis 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6950
MeSH 45 D003130
UMLS 74 C0009426
Sources

Summaries for Combat Disorder

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Disease Ontology : 12 An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress.

MalaCards based summary : Combat Disorder, also known as combat disorders, is related to neurotic disorder and acute stress disorder. An important gene associated with Combat Disorder is DIS3 (DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease), and among its related pathways/superpathways are amb2 Integrin signaling and MSP-RON Signaling. The drugs Tramadol and Fluoxetine have been mentioned in the context of this disorder. Related phenotypes are digestive/alimentary and immune system

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Related Diseases for Combat Disorder

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Diseases related to Combat Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neurotic disorder 10.3
2 acute stress disorder 9.3 ACKR1 DIS3 MST1 TRAF3IP2

Sources

Symptoms & Phenotypes for Combat Disorder

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MGI Mouse Phenotypes related to Combat Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 ASPH DROSHA MST1 TRAF3IP2
2 immune system MP:0005387 9.02 ACKR1 DROSHA MST1 MST1R TRAF3IP2
Sources

Drugs & Therapeutics for Combat Disorder

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Drugs for Combat Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
4 Peripheral Nervous System Agents Phase 4
5 Analgesics Phase 4
6 Analgesics, Opioid Phase 4
7 Narcotics Phase 4
8 Central Nervous System Depressants Phase 4,Not Applicable
9 Serotonin Agents Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Antidepressive Agents Phase 4
12 Serotonin Uptake Inhibitors Phase 4
13 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Not Applicable
14 Antidepressive Agents, Second-Generation Phase 4
15 Psychotropic Drugs Phase 4
16 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
17 Neurotransmitter Uptake Inhibitors Phase 4
18 Quetiapine Fumarate Phase 4 111974-72-2
19 Tranquilizing Agents Phase 4
20 Antipsychotic Agents Phase 4
21
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
22
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
23
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
24 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
25 Hydrocortisone hemisuccinate Phase 2, Phase 3
26
Prazosin Approved Phase 1, Phase 2,Phase 2,Not Applicable 19216-56-9 4893
27 Omega 3 Fatty Acid Phase 2
28 Adrenergic alpha-1 Receptor Antagonists Phase 1, Phase 2,Not Applicable
29 Adrenergic Agents Phase 1, Phase 2,Not Applicable
30 Adrenergic alpha-Antagonists Phase 1, Phase 2,Not Applicable
31 Antihypertensive Agents Phase 1, Phase 2,Not Applicable
32 Adrenergic Antagonists Phase 1, Phase 2,Not Applicable
33
Cycloserine Approved Not Applicable 68-41-7 6234 401
34
Ethanol Approved Not Applicable 64-17-5 702
35 Antibiotics, Antitubercular Not Applicable
36 Anti-Infective Agents Not Applicable
37 Antitubercular Agents Not Applicable
38 Anti-Infective Agents, Urinary Not Applicable
39 Nootropic Agents Not Applicable
40 Antimetabolites Not Applicable
41 Renal Agents Not Applicable
42 Anti-Bacterial Agents Not Applicable
43 Anti-Infective Agents, Local Not Applicable

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
2 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
3 Quetiapine Augmentation for Treatment-resistant PTSD Completed NCT00292370 Phase 4 Open Label (OL) Paroxetine;Placebo;Quetiapine
4 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
5 Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms Completed NCT00475241 Phase 2, Phase 3
6 Military to Civilian: Trial of an Intervention to Promote Postdeployment Reintegration Completed NCT00640445 Phase 2, Phase 3
7 Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders Unknown status NCT01216982 Phase 2 Lovaza, omega-3 fatty acid ethyl ester;Placebo, visually identical to Lovaza
8 Trauma Management Therapy for OEF and OIF Combat Veterans Completed NCT02809326 Phase 2
9 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin Recruiting NCT02266329 Phase 1, Phase 2 prazosin hydrochloride;placebo
10 Exercise: A Novel Treatment for Combat Post Traumatic Stress Disorder Terminated NCT01626131 Phase 2
11 Trial of Oral SNC-102 in Subjects With Combat-Related Posttraumatic Stress Disorder Withdrawn NCT02384369 Phase 2 SNC-102 sustained release tablet
12 Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment Unknown status NCT01007006 Not Applicable
13 Prospective Study of Veteran Health in Previously Deployed Soldiers Completed NCT00285246
14 A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD Completed NCT00371176 Not Applicable D-Cycloserine
15 Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder Completed NCT00539279 Not Applicable
16 Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) Among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Personnel Completed NCT01049516 Not Applicable
17 Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings Completed NCT00974402 Not Applicable
18 Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) Completed NCT00990106 Not Applicable prazosin hydrochloride;placebo
19 Reintegration: The Role of Spouse Telephone BATTLEMIND Pilot Study Completed NCT00870545 Not Applicable
20 Prolonged Exposure Versus Treatment as Usual in Chronic Posttraumatic Stress Disorder Combat and Terror Related Patients Completed NCT00229372 Not Applicable
21 Motivational Interviewing to Engage Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans in Mental Health Treatment Completed NCT00419029 Not Applicable
22 Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders Completed NCT01338506 Not Applicable
23 Comparing Virtual Reality Exposure Therapy to Prolonged Exposure Completed NCT01459705 Not Applicable
24 Exposure Therapy for Active Duty Soldiers With Post Traumatic Stress Disorder Completed NCT01193725 Not Applicable
25 Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups Completed NCT01121250 Not Applicable
26 Exploring Deployment Stress and Reintegration in Army National Guard Chaplains Completed NCT01330888
27 CBT for Aggression in Veterans Completed NCT02233517 Not Applicable
28 Examining the Effect of Acupuncture on Sleep Difficulties Related to Post Traumatic Stress Disorder Completed NCT00868517 Not Applicable
29 Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Recruiting NCT03795987 Not Applicable
30 Vietnam Era Health Retrospective Observational Study Active, not recruiting NCT02825602
31 The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD Active, not recruiting NCT02720497 Not Applicable
32 An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military Active, not recruiting NCT03337750 Not Applicable
33 A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel Active, not recruiting NCT02556645 Not Applicable
34 Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD Active, not recruiting NCT02226367 Not Applicable prazosin hydrochloride;placebo
35 Long-term Health Outcomes of AE Casualties Enrolling by invitation NCT03736356
36 NightWare Open Enrollment Study Enrolling by invitation NCT03828656 Not Applicable
37 Remote Study of NightWare for PTSD With Nightmares Not yet recruiting NCT03934658 Not Applicable
38 FOCUS-CI: A Preventive Intervention With Children and Families of the Combat Injured Terminated NCT01062022 Not Applicable
39 Effect of Prazosin on Neurophysiology and Cognition in Post-Traumatic Stress Disorder (PTSD) Withdrawn NCT00890643 Not Applicable prazosin hydrochloride;placebo

Search NIH Clinical Center for Combat Disorder

Cochrane evidence based reviews: combat disorders

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Genetic Tests for Combat Disorder

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Anatomical Context for Combat Disorder

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Publications for Combat Disorder

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Articles related to Combat Disorder:

# Title Authors Year
1
Historical approaches to post-combat disorders. ( 16687259 )
2006
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Variations for Combat Disorder

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Expression for Combat Disorder

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Search GEO for disease gene expression data for Combat Disorder.
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Pathways for Combat Disorder

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Pathways related to Combat Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
amb2 Integrin signaling 1
10.94 MST1 MST1R
2
MSP-RON Signaling 65
10.84 MST1 MST1R
3
a6b1 and a6b4 Integrin signaling 1
10.45 MST1 MST1R
4
Signaling by MST1 67
9.32 MST1 MST1R
Sources

GO Terms for Combat Disorder

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Cellular components related to Combat Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vacuole GO:0005773 8.62 MST1 MST1R

Biological processes related to Combat Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.26 ACKR1 MST1R
2 nucleic acid phosphodiester bond hydrolysis GO:0090305 9.16 DIS3 DROSHA
3 rRNA catabolic process GO:0016075 8.96 DIS3 DROSHA
4 hepatocyte growth factor receptor signaling pathway GO:0048012 8.62 MST1 MST1R

Molecular functions related to Combat Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclease activity GO:0004518 8.96 DIS3 DROSHA
2 endonuclease activity GO:0004519 8.62 DIS3 DROSHA
Sources

Sources for Combat Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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