MCID: CMB002
MIFTS: 22

Combat Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Combat Disorder

MalaCards integrated aliases for Combat Disorder:

Name: Combat Disorder 12 15
Combat Disorders 44 72
Combat Neurosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6950
MeSH 44 D003130
UMLS 72 C0009426

Summaries for Combat Disorder

Disease Ontology : 12 An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress.

MalaCards based summary : Combat Disorder, also known as combat disorders, is related to acute stress disorder and neurotic disorder. An important gene associated with Combat Disorder is DIS3 (DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease). The drugs Tramadol and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Combat Disorder

Diseases related to Combat Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 acute stress disorder 27.3 TRAF3IP2 MST1 DIS3 ACKR1
2 neurotic disorder 10.4
3 post-traumatic stress disorder 9.7
4 dyspepsia 9.7
5 persian gulf syndrome 9.7

Graphical network of the top 20 diseases related to Combat Disorder:



Diseases related to Combat Disorder

Symptoms & Phenotypes for Combat Disorder

Drugs & Therapeutics for Combat Disorder

Drugs for Combat Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
4 Neurotransmitter Agents Phase 4
5 Analgesics Phase 4
6 Narcotics Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Analgesics, Opioid Phase 4
9 Serotonin Uptake Inhibitors Phase 4
10 Antidepressive Agents Phase 4
11 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
12 Tranquilizing Agents Phase 4
13 Antidepressive Agents, Second-Generation Phase 4
14 Quetiapine Fumarate Phase 4 111974-72-2
15 Cytochrome P-450 Enzyme Inhibitors Phase 4
16 Serotonin Agents Phase 4
17 Neurotransmitter Uptake Inhibitors Phase 4
18 Antipsychotic Agents Phase 4
19 Psychotropic Drugs Phase 4
20
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
21
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
22
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
23 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
24 Hydrocortisone hemisuccinate Phase 2, Phase 3
25 Omega 3 Fatty Acid Phase 2
26 Antihypertensive Agents Phase 1, Phase 2
27 Adrenergic alpha-Antagonists Phase 1, Phase 2
28 Adrenergic alpha-1 Receptor Antagonists Phase 1, Phase 2
29 Adrenergic Agents Phase 1, Phase 2
30 Adrenergic Antagonists Phase 1, Phase 2
31
Cycloserine Approved 68-41-7 6234 401
32
Ethanol Approved 64-17-5 702
33 Central Nervous System Depressants
34 Nootropic Agents
35 Renal Agents
36 Anti-Bacterial Agents
37 Antitubercular Agents
38 Antibiotics, Antitubercular
39 Anti-Infective Agents, Urinary
40 Antimetabolites
41 Anti-Infective Agents
42 Anti-Infective Agents, Local

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 A Double-Blind, Placebo-Controlled, Flexible-Dose Pilot Clinical Trial of Once-Daily Extended-Release Tramadol for the Treatment of PTSD Unknown status NCT01517711 Phase 4 Tramadol;Placebo
2 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
3 A Placebo-controlled Trial of Adjunctive Quetiapine for Refractory PTSD Completed NCT00292370 Phase 4 Open Label (OL) Paroxetine;Placebo;Quetiapine
4 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
5 Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms Completed NCT00475241 Phase 2, Phase 3
6 Military to Civilian: RCT of an Intervention to Promote Postdeployment Reintegration Completed NCT00640445 Phase 2, Phase 3
7 Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders: A Mood Resilience Trial Unknown status NCT01216982 Phase 2 Lovaza, omega-3 fatty acid ethyl ester;Placebo, visually identical to Lovaza
8 Trauma Management Therapy for OEF and OIF Combat Veterans Completed NCT02809326 Phase 2
9 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin Recruiting NCT02266329 Phase 1, Phase 2 prazosin hydrochloride;placebo
10 Exercise: A Novel Treatment for Combat PTSD Terminated NCT01626131 Phase 2
11 Phase 2a, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating Efficacy, Safety, and Pharmacokinetics of Orally Administered SNC-102 in Subjects With Combat-Related Posttraumatic Stress Disorder Concomitantly Treated With Prazosin Withdrawn NCT02384369 Phase 2 SNC-102 sustained release tablet
12 Psychotherapy Treatment of Deployment-related PTSD in Primary Care Settings Completed NCT00974402
13 Prospective Study of Functional Status in Veterans at Risk for Unexplained Illnesses Completed NCT00285246
14 A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD Completed NCT00371176 D-Cycloserine
15 Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder Completed NCT00539279
16 Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups Completed NCT01121250
17 Reintegration: The Role of Spouse Telephone BATTLEMIND Pilot Study Completed NCT00870545
18 Exploring Deployment Stress and Reintegration in Army National Guard Chaplains Completed NCT01330888
19 Motivational Interviewing to Engage OEF/OIF Veterans in Mental Health Treatment Completed NCT00419029
20 A Placebo-Controlled Augmentation Trial of Prazosin for PTSD Completed NCT00990106 prazosin hydrochloride;placebo
21 The Effect of Acupuncture on PTSD-Related Insomnia Completed NCT00868517
22 Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With Post Traumatic Stress Disorder (PTSD) Completed NCT01459705
23 Comparing Virtual Reality Exposure Therapy to Prolonged Exposure in the Treatment of Soldiers With PTSD Completed NCT01193725
24 Integrated Treatment of Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Post-traumatic Stress Disorder and Substance Use Disorders Completed NCT01338506
25 Group Cognitive Behavioral Therapy for Anger and Aggression in Veterans With PTSD Completed NCT02233517
26 Prolonged Exposure for PTSD Among OIF/OEF Personnel: Massed vs. Spaced Trials Completed NCT01049516
27 A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel Completed NCT02556645
28 Evaluation of the Impact of Diving Training on Recovery in a Cohort of Veterans Suffering of PTSD: an Exploratory Clinical Control Trial Recruiting NCT03995992
29 A Remote Randomized Double-Blind Sham-Controlled Clinical Trial of NightWare in Adults With Post-Traumatic Stress Disorder and Co-Morbid Nightmare Disorder Recruiting NCT03934658
30 TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Recruiting NCT04040387
31 Prospective Evaluation of Health Outcomes in AE Casualties: a Pilot Study Active, not recruiting NCT03736356
32 An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military Active, not recruiting NCT03337750
33 Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD Active, not recruiting NCT02226367 prazosin hydrochloride;placebo
34 Vietnam Era Health Retrospective Observational Study Active, not recruiting NCT02825602
35 TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Active, not recruiting NCT03795987
36 The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD: A Randomized Controlled Trial in Active Duty Military Personnel Active, not recruiting NCT02720497
37 NightWare Open Enrollment Study Enrolling by invitation NCT03828656
38 FOCUS-CI: A Preventive Intervention With Children and Families of the Combat Injured Terminated NCT01062022
39 Evaluation of a Telepharmacy Robotic Medicine Delivery Unit in Warrior Transition Unit Patients With Traumatic Brain Injury, Post-Traumatic Stress Disorder, or Polytrauma Withdrawn NCT01007006
40 Effect of Prazosin on Neurophysiologic Responses and Cognitive Performance in PTSD Withdrawn NCT00890643 prazosin hydrochloride;placebo

Search NIH Clinical Center for Combat Disorder

Cochrane evidence based reviews: combat disorders

Genetic Tests for Combat Disorder

Anatomical Context for Combat Disorder

MalaCards organs/tissues related to Combat Disorder:

41
Brain

Publications for Combat Disorder

Articles related to Combat Disorder:

(show all 17)
# Title Authors PMID Year
1
A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo. 38
30223587 2018
2
Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. 38
30275974 2018
3
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. 38
27125741 2016
4
Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein. 38
26116876 2015
5
[Traumatic psychological combat disorders. Extraordinary experiences]. 38
25975160 2015
6
Nothing new under the sun: post-traumatic stress disorders in the ancient world. 38
25577928 2014
7
Gulf War Syndrome: a review of current knowledge and understanding. 38
25895403 2014
8
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder. 38
23842024 2013
9
Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. 38
21323908 2011
10
Prevalence of chronic pain after traumatic brain injury: a systematic review. 38
18698069 2008
11
Nicotinic receptors containing the alpha7 subunit: a model for rational drug design. 38
19075644 2008
12
[Characteristics of combat disorders in war veterans committed illegal aggressive actions]. 38
17902346 2007
13
Historical approaches to post-combat disorders. 38
16687259 2006
14
Flashbacks and post-traumatic stress disorder: the genesis of a 20th-century diagnosis. 38
12562745 2003
15
Post-combat syndromes from the Boer war to the Gulf war: a cluster analysis of their nature and attribution. 38
11834557 2002
16
Mortality of former prisoners of war and other Australian veterans. 38
1630377 1992
17
Chronic morbidity of former prisoners of war and other Australian veterans. 38
1943902 1991

Variations for Combat Disorder

Expression for Combat Disorder

Search GEO for disease gene expression data for Combat Disorder.

Pathways for Combat Disorder

GO Terms for Combat Disorder

Sources for Combat Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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