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MCID: CMB002
MIFTS: 30

Combat Disorder

Categories: Mental diseases, Neuronal diseases
Genes Related diseases Publications Pathways Drugs
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Aliases & Classifications for Combat Disorder

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MalaCards integrated aliases for Combat Disorder:

Name: Combat Disorder 12 15
Combat Disorders 44 71
Combat Neurosis 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6950
MeSH 44 D003130
UMLS 71 C0009426
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Summaries for Combat Disorder

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Disease Ontology : 12 An acute stress disorder that involves neurotic reactions to unusual, severe, or overwhelming military stress.

MalaCards based summary : Combat Disorder, also known as combat disorders, is related to acute stress disorder and cork-handlers' disease. An important gene associated with Combat Disorder is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Yersinia infection and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Tramadol and Fluoxetine have been mentioned in the context of this disorder.

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Related Diseases for Combat Disorder

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Diseases related to Combat Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
# Related Disease Score Top Affiliating Genes
1 acute stress disorder 29.9 SERPINA3 NENF IL6 CD8A
2 cork-handlers' disease 10.4 CD8A CD4
3 necrotic uveal melanoma 10.4 CD8A CD4
4 early yaws 10.4 CD8A CD4
5 ventilation pneumonitis 10.4 CD8A CD4
6 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
7 latent syphilis 10.4 CD8A CD4
8 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
9 parapsoriasis 10.4 CD8A CD4
10 gastroduodenitis 10.4 CD8A CD4
11 primary syphilis 10.4 CD8A CD4
12 norwegian scabies 10.4 CD8A CD4
13 bird fancier's lung 10.4 CD8A CD4
14 metal allergy 10.4 CD8A CD4
15 variola major 10.4 CD8A CD4
16 follicular mucinosis 10.3 CD8A CD4
17 spongiotic dermatitis 10.3 CD8A CD4
18 cerebral lymphoma 10.3 CD8A CD4
19 invasive malignant thymoma 10.3 CD8A CD4
20 syphilis 10.3 SERPINA3 CD8A CD4
21 neurotic disorder 10.3
22 west nile encephalitis 10.3 CD8A CD4
23 exanthema subitum 10.3 CD8A CD4
24 immunodeficiency 36 10.3 CD8A CD4
25 transient arthritis 10.3 IL6 CD4
26 secondary syphilis 10.3 CD8A CD4
27 glanders 10.3 CD8A CD4
28 chediak-higashi syndrome 10.3 SERPINA3 CD8A CD4
29 oral hairy leukoplakia 10.3 CD8A CD4
30 polyclonal hypergammaglobulinemia 10.2 SERPINA3 IL6 CD4
31 acute retinal necrosis syndrome 10.2 IL6 CD8A CD4
32 autoimmune disease of peripheral nervous system 10.2 IL6 CD8A CD4
33 external ear disease 10.2 IL6 CD4
34 cowpox 10.2 IL6 CD8A CD4
35 thyroid gland disease 10.2 SERPINA3 IL6 CD4
36 mature b-cell neoplasm 10.2 IL6 CD8A CD4
37 toxicodendron dermatitis 10.2 TNF CD8A
38 rheumatoid arthritis interstitial lung disease 10.2 TNF CD4
39 substance abuse 10.2 SERPINA3 IL6 CD4
40 listeria meningitis 10.2 TNF CD8A
41 esophageal candidiasis 10.2 CD8A CD4
42 meningovascular neurosyphilis 10.1 TNF CD4
43 opportunistic bacterial infectious disease 10.1 TNF CD4
44 external pathological resorption 10.1 TNF IL6
45 scorpion envenomation 10.1 TNF IL6
46 physiological polycythemia 10.1 TNF IL6
47 nocardiosis 10.1 TNF CD4
48 arachnoiditis 10.1 TNF CD4
49 aspiration pneumonitis 10.1 TNF SERPINA3
50 parotid disease 10.1 CD8A CD4

Graphical network of the top 20 diseases related to Combat Disorder:



Diseases related to Combat Disorder
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Symptoms & Phenotypes for Combat Disorder

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Drugs & Therapeutics for Combat Disorder

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Drugs for Combat Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
4 Narcotics Phase 4
5 Analgesics, Opioid Phase 4
6 Analgesics Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Antidepressive Agents Phase 4
9 Quetiapine Fumarate Phase 4 111974-72-2
10 Antipsychotic Agents Phase 4
11 Serotonin Uptake Inhibitors Phase 4
12
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
13
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
14 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
15 Hydrocortisone hemisuccinate Phase 2, Phase 3
16 Omega 3 Fatty Acid Phase 2
17 Adrenergic alpha-1 Receptor Antagonists Phase 1, Phase 2
18 Adrenergic alpha-Antagonists Phase 1, Phase 2
19 Adrenergic Antagonists Phase 1, Phase 2
20 Antihypertensive Agents Phase 1, Phase 2
21 Neurotransmitter Agents Phase 2
22 Psychotropic Drugs Phase 2
23 Hallucinogens Phase 2
24 Adrenergic Agents Phase 2
25 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
26
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
27
Cycloserine Approved 68-41-7 401 6234
28
Ethanol Approved 64-17-5 702
29 Antibiotics, Antitubercular
30 Antitubercular Agents
31 Anti-Infective Agents
32 Anti-Bacterial Agents
33 Antimetabolites

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 A Double-Blind, Placebo-Controlled, Flexible-Dose Pilot Clinical Trial of Once-Daily Extended-Release Tramadol for the Treatment of PTSD Unknown status NCT01517711 Phase 4 Tramadol;Placebo
2 Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure Unknown status NCT00633685 Phase 4 Fluoxetine;Placebo
3 A Placebo-controlled Trial of Adjunctive Quetiapine for Refractory PTSD Completed NCT00292370 Phase 4 Open Label (OL) Paroxetine;Placebo;Quetiapine
4 A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder Unknown status NCT00978484 Phase 3
5 Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms Completed NCT00475241 Phase 2, Phase 3
6 Effects of Omega-3 EPA/DHA for Soldiers at Risk for Mood Disorders: A Mood Resilience Trial Unknown status NCT01216982 Phase 2 Lovaza, omega-3 fatty acid ethyl ester;Placebo, visually identical to Lovaza
7 Trauma Management Therapy for OEF and OIF Combat Veterans Completed NCT02809326 Phase 2
8 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin Recruiting NCT02266329 Phase 1, Phase 2 prazosin hydrochloride;placebo
9 Open-label Phase 2 Study of MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD Not yet recruiting NCT04264026 Phase 2 3,4-methylenedioxymethamphetamine
10 Exercise: A Novel Treatment for Combat PTSD Terminated NCT01626131 Phase 2
11 Phase 2a, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating Efficacy, Safety, and Pharmacokinetics of Orally Administered SNC-102 in Subjects With Combat-Related Posttraumatic Stress Disorder Concomitantly Treated With Prazosin Withdrawn NCT02384369 Phase 2 SNC-102 sustained release tablet
12 Prospective Study of Functional Status in Veterans at Risk for Unexplained Illnesses Completed NCT00285246
13 Motivational Interviewing to Engage OEF/OIF Veterans in Mental Health Treatment Completed NCT00419029
14 A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD Completed NCT00371176 D-Cycloserine
15 Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder Completed NCT00539279
16 Integrated Treatment of Operation Enduring Freedom/Operation Iraqi Freedom Veterans With Post-traumatic Stress Disorder and Substance Use Disorders Completed NCT01338506
17 Prolonged Exposure for PTSD Among OIF/OEF Personnel: Massed vs. Spaced Trials Completed NCT01049516
18 A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel Completed NCT02556645
19 TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Completed NCT03795987
20 Exploring Deployment Stress and Reintegration in Army National Guard Chaplains Completed NCT01330888
21 A Placebo-Controlled Augmentation Trial of Prazosin for PTSD Completed NCT00990106 prazosin hydrochloride;placebo
22 Psychotherapy Treatment of Deployment-related PTSD in Primary Care Settings Completed NCT00974402
23 Reintegration: The Role of Spouse Telephone BATTLEMIND Pilot Study Completed NCT00870545
24 Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD Completed NCT02226367 prazosin hydrochloride;placebo
25 An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military Completed NCT03337750
26 Evaluation of the Impact of Diving Training on Recovery in a Cohort of Veterans Suffering of PTSD: an Exploratory Clinical Control Trial Recruiting NCT03995992
27 The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD: A Randomized Controlled Trial in Active Duty Military Personnel Active, not recruiting NCT02720497
28 Vietnam Era Health Retrospective Observational Study Active, not recruiting NCT02825602
29 NightWare Open Enrollment Study Enrolling by invitation NCT03828656
30 TNT/NW: Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken) Enrolling by invitation NCT04040387
31 A Remote Randomized Double-Blind Sham-Controlled Clinical Trial of NightWare in Adults With Post-Traumatic Stress Disorder and Co-Morbid Nightmare Disorder Enrolling by invitation NCT03934658
32 FOCUS-CI: A Preventive Intervention With Children and Families of the Combat Injured Terminated NCT01062022
33 Prospective Evaluation of Health Outcomes in AE Casualties: a Pilot Study Terminated NCT03736356
34 Evaluation of a Telepharmacy Robotic Medicine Delivery Unit in Warrior Transition Unit Patients With Traumatic Brain Injury, Post-Traumatic Stress Disorder, or Polytrauma Withdrawn NCT01007006

Search NIH Clinical Center for Combat Disorder

Cochrane evidence based reviews: combat disorders

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Genetic Tests for Combat Disorder

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Anatomical Context for Combat Disorder

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Publications for Combat Disorder

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Articles related to Combat Disorder:

(show all 17)
# Title Authors PMID Year
1
A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo. 61
30223587 2018
2
Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. 61
30275974 2018
3
The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. 61
27125741 2016
4
Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein. 61
26116876 2015
5
[Traumatic psychological combat disorders. Extraordinary experiences]. 61
25975160 2015
6
Nothing new under the sun: post-traumatic stress disorders in the ancient world. 61
25577928 2014
7
Gulf War Syndrome: a review of current knowledge and understanding. 61
25895403 2014
8
Meta-analysis of the efficacy of treatments for posttraumatic stress disorder. 61
23842024 2013
9
Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. 61
21323908 2011
10
Prevalence of chronic pain after traumatic brain injury: a systematic review. 61
18698069 2008
11
Nicotinic receptors containing the alpha7 subunit: a model for rational drug design. 61
19075644 2008
12
[Characteristics of combat disorders in war veterans committed illegal aggressive actions]. 61
17902346 2007
13
Historical approaches to post-combat disorders. 61
16687259 2006
14
Flashbacks and post-traumatic stress disorder: the genesis of a 20th-century diagnosis. 61
12562745 2003
15
Post-combat syndromes from the Boer war to the Gulf war: a cluster analysis of their nature and attribution. 61
11834557 2002
16
Mortality of former prisoners of war and other Australian veterans. 61
1630377 1992
17
Chronic morbidity of former prisoners of war and other Australian veterans. 61
1943902 1991
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Variations for Combat Disorder

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Expression for Combat Disorder

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Search GEO for disease gene expression data for Combat Disorder.
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Pathways for Combat Disorder

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Pathways related to Combat Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Yersinia infection 36
11.76 TNF IL6 CD8A CD4
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 TNF IL6 CD8A CD4
3
Innate Lymphoid Cell Differentiation Pathways 64
11.48 TNF CD8A CD4
4
Th1 Differentiation Pathway 64
Show member pathways
 11.43 TNF IL6 CD4
5
Hematopoietic cell lineage 36
11.25 TNF IL6 CD8A CD4
6
Cytokines and Inflammatory Response 1
10.79 TNF IL6 CD4
7
Dendritic Cells Developmental Lineage Pathway 64
10.79 TNF IL6 CD8A CD4
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GO Terms for Combat Disorder

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Biological processes related to Combat Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.33 TNF NTF4 IL6
2 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.32 TNF IL6
3 positive regulation of neuroinflammatory response GO:0150078 9.26 TNF IL6
4 negative regulation of lipid storage GO:0010888 8.96 TNF IL6
5 vascular endothelial growth factor production GO:0010573 8.62 TNF IL6
Sources

Sources for Combat Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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