MCID: CMB089
MIFTS: 17

Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Categories: Cancer diseases, Liver diseases, Rare diseases

Aliases & Classifications for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MalaCards integrated aliases for Combined Hepatocellular Carcinoma and Cholangiocarcinoma:

Name: Combined Hepatocellular Carcinoma and Cholangiocarcinoma 59
Combined Hepatocellular-Cholangiocarcinoma 59
Hepatocholangiocarcinoma 59
Combined Hcc-Cc 59
Chcc-Cc 59

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Orphanet 59 ORPHA529852

Summaries for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MalaCards based summary : Combined Hepatocellular Carcinoma and Cholangiocarcinoma, also known as combined hepatocellular-cholangiocarcinoma, is related to cholangiocarcinoma and intrahepatic cholangiocarcinoma. An important gene associated with Combined Hepatocellular Carcinoma and Cholangiocarcinoma is SALL4 (Spalt Like Transcription Factor 4). Affiliated tissues include liver.

Related Diseases for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Diseases related to Combined Hepatocellular Carcinoma and Cholangiocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 44, show less)
# Related Disease Score Top Affiliating Genes
1 cholangiocarcinoma 10.8
2 intrahepatic cholangiocarcinoma 10.8
3 hepatocellular carcinoma 10.8
4 liver cirrhosis 10.3
5 viral hepatitis 10.3
6 rare tumor 10.2
7 hepatitis c virus 10.2
8 spindle cell carcinoma 10.2
9 cholelithiasis 10.1
10 polyneuropathy 10.1
11 squamous cell carcinoma 10.1
12 demyelinating polyneuropathy 10.1
13 chronic inflammatory demyelinating polyneuropathy 10.1
14 dysphagia 10.1
15 paraneoplastic syndromes 10.1
16 alcohol dependence 10.0
17 non-alcoholic fatty liver disease 10.0
18 obstructive jaundice 10.0
19 hepatitis c 10.0
20 hepatitis b 10.0
21 mucinous adenocarcinoma 10.0
22 cystadenocarcinoma 10.0
23 liver disease 10.0
24 tubular adenocarcinoma 10.0
25 hepatoblastoma 10.0
26 cholangiolocellular carcinoma 10.0
27 fatty liver disease 10.0
28 acute sensory ataxic neuropathy 10.0
29 colorectal cancer 10.0
30 schistosoma mansoni infection, susceptibility/ 10.0
31 tetralogy of fallot 10.0
32 budd-chiari syndrome 10.0
33 convulsions, familial infantile, with paroxysmal choreoathetosis 10.0
34 angiosarcoma 10.0
35 non-alcoholic steatohepatitis 10.0
36 dermatomyositis 10.0
37 portal vein thrombosis 10.0
38 schistosomiasis 10.0
39 colon adenocarcinoma 10.0
40 gallbladder cancer 10.0
41 fibrolamellar carcinoma 10.0
42 pulmonary embolism 10.0
43 nodular regenerative hyperplasia 10.0
44 posttransplant acute limbic encephalitis 10.0

Graphical network of the top 20 diseases related to Combined Hepatocellular Carcinoma and Cholangiocarcinoma:



Diseases related to Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Symptoms & Phenotypes for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Drugs & Therapeutics for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Search Clinical Trials , NIH Clinical Center for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Genetic Tests for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Anatomical Context for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MalaCards organs/tissues related to Combined Hepatocellular Carcinoma and Cholangiocarcinoma:

41
Liver

Publications for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Articles related to Combined Hepatocellular Carcinoma and Cholangiocarcinoma:

(showing 84, show less)
# Title Authors PMID Year
1
Imaging features of combined hepatocellular and cholangiocarcinoma compared with those of hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma in a Chinese population. 38
30799097 2019
2
Combined Hepatocholangiocarcinoma Associated with Humoral Hypercalcemia of Malignancy and Chronic Inflammatory Demyelinating Polyneuropathy. 38
31341687 2019
3
Comparing Clonality Between Components of Combined Hepatocellular Carcinoma and Cholangiocarcinoma by Targeted Sequencing. 38
29976634 2018
4
Rapidly progressing lepidic pulmonary metastases from a treated poorly differentiated hepatocellular carcinoma demonstrating new pathologic features of cholangiocarcinoma: A potential diagnostic pitfall that may mimic pneumonia. 38
29904468 2018
5
Hepatocholangiocarcinoma/intrahepatic cholangiocarcinoma: are they contraindication or indication for liver transplantation? A propensity score-matched analysis. 38
29450868 2018
6
Esophageal metastasis of stem cell-subtype hepatocholangiocarcinoma: Rare presentation of a rare tumor. 38
29467557 2018
7
Gemcitabine plus platinum-based chemotherapy for first-line treatment of hepatocholangiocarcinoma: an AGEO French multicentre retrospective study. 38
29169182 2018
8
Retinal and vitreous metastases from hepatocholangiocarcinoma. 38
28629380 2017
9
Importance of surgical margin in the outcomes of hepatocholangiocarcinoma. 38
28539991 2017
10
[Hepatocholangiocarcinoma in young patient with a giant liver tumour]. 38
27012432 2017
11
Post-resection Prognosis of Combined Hepatocellular Carcinoma-Cholangiocarcinoma According to the 2010 WHO Classification. 38
27896409 2017
12
Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance. 38
27634656 2017
13
Living Donor Liver Transplantation for Combined Hepatocellular Carcinoma and Cholangiocarcinoma: Experience of a Single Center. 38
28242867 2017
14
Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma. 38
27276713 2016
15
Imaging Features of Biphenotypic Primary Liver Carcinoma (Hepatocholangiocarcinoma) and the Potential to Mimic Hepatocellular Carcinoma: LI-RADS Analysis of CT and MRI Features in 61 Cases. 38
26866746 2016
16
Combined Hepatocellular Carcinoma and Cholangiocarcinoma: Diagnosis and Prognosis After Resection or Transplantation. 38
27320566 2016
17
Spalt-like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma. 38
26267070 2016
18
Incidental Intra-Hepatic Cholangiocarcinoma and Hepatocholangiocarcinoma in Liver Transplantation: A Single-Center Experience. 38
27109957 2016
19
Combined hepatocellular carcinoma and cholangiocarcinoma (biphenotypic) tumors: clinical characteristics, imaging features of contrast-enhanced ultrasound and computed tomography. 38
26917546 2016
20
Postresection Outcomes of Combined Hepatocellular Carcinoma-Cholangiocarcinoma, Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. 38
26628072 2016
21
Osteopontin Promotes Hepatic Progenitor Cell Expansion and Tumorigenicity via Activation of β-Catenin in Mice. 38
26033745 2015
22
A case of hepatoblastoma misdiagnosed as combined hepatocellular carcinoma and cholangiocarcinoma in an adult. 38
26523273 2015
23
Intrahepatic cholangiocarcinoma: expert consensus statement. 38
26172134 2015
24
Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery. 38
25475861 2014
25
GEMOX as the best hope for combined hepatocellular carcinoma and cholangiocarcinoma? 38
25327932 2014
26
Inverse correlation of ribosomal protein S27A and multifunctional protein YB-1 in hepatocellular carcinoma. 38
24833360 2014
27
Combined hepatocellular-cholangiocarcinoma with fever of unknown origin: a case report and review of literature. 38
24068520 2014
28
Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. 38
24503412 2014
29
[Clinical characteristics and prognosis of three rare and poor-prognostic subtypes of primary liver carcinoma]. 38
24785282 2014
30
Clinicopathological characteristics and prognostic factors in combined hepatocellular carcinoma and cholangiocarcinoma. 38
26155231 2013
31
Elevated expression of Bmi1 in hepatocellular carcinoma with bile duct tumor thrombi. 38
24719948 2013
32
Long-term outcome of liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma. 38
24157031 2013
33
Gallbladder metastatic combined hepatocellular carcinoma and cholangiocarcinoma without primary intrahepatic tumor. 38
23703449 2013
34
Clinicopathological factors impact the survival outcome following the resection of combined hepatocellular carcinoma and cholangiocarcinoma. 38
23102615 2013
35
Exophytic combined hepatocellular carcinoma and cholangiocarcinoma. 38
23323259 2012
36
Toxicology and carcinogenesis studies of trimethylolpropane triacrylate (technical grade) (CASRN 15625-89-5) in F344/N rats and B6C3F1/N mice (dermal studies). 38
23385646 2012
37
Combined hepatocellular carcinoma and cholangiocarcinoma: clinical features, treatment modalities, and prognosis. 38
22451237 2012
38
Copy number aberrations in combined hepatocellular carcinoma and cholangiocarcinoma. 38
22366251 2012
39
Anatomical liver segmentectomy 2 for combined hepatocellular carcinoma and cholangiocarcinoma with tumor thrombus in segment 2 portal branch. 38
22273493 2012
40
Primary hepatic cancers with multiple pathologic features in a patient with hepatitis C: report of a case. 38
23101996 2012
41
Clinicopathological analysis of 14 patients with combined hepatocellular carcinoma and cholangiocarcinoma. 38
22146626 2011
42
Clinicopathologic study on combined hepatocellular carcinoma and cholangiocarcinoma: with emphasis on the intermediate cell morphology. 38
21860552 2011
43
Rapid progression of combined hepatocellular carcinoma and cholangiocarcinoma. 38
21507775 2011
44
Proceedings of the 2010 National Toxicology Program Satellite Symposium. 38
21177527 2011
45
Nonresectable combined hepatocellular carcinoma and cholangiocarcinoma: analysis of the response and prognostic factors after transcatheter arterial chemoembolization. 38
20308463 2010
46
An update on long-term outcome of curative hepatic resection for hepatocholangiocarcinoma. 38
19548027 2009
47
Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas. 38
19446907 2009
48
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival. 38
19446912 2009
49
Surgical treatments and prognoses of patients with combined hepatocellular carcinoma and cholangiocarcinoma. 38
19130133 2009
50
Combined hepatocellular carcinoma and cholangiocarcinoma: a case report and review of the literature. 38
18086637 2007
51
Clinicopathological characteristics of 15 patients with combined hepatocellular carcinoma and cholangiocarcinoma. 38
17374575 2007
52
Combined hepatocellular and cholangiocarcinoma: CT findings with emphasis on multiphasic helical CT. 38
17621741 2007
53
Safety of prolonged intermittent pringle maneuver during hepatic resection. 38
16847234 2006
54
Combined hepatocellular carcinoma and cholangiocarcinoma with components of mucinous carcinoma arising in a cirrhotic liver. 38
16634969 2006
55
Combined hepatocholangiocarcinoma: case-series and review of literature. 38
17290078 2006
56
A case report of synchronous double primary liver cancers combined with early gastric cancer. 38
12872450 2003
57
Primary liver cancer with dual expression of hepatocyte and bile duct epithelial markers. 38
12143210 2002
58
Surgically treated cases of mixed hepatocellular carcinoma and cholangiocarcinoma. 38
12143207 2002
59
The separate-lesion type combined hepatocellular carcinoma and cholangiocarcinoma. 38
12063995 2002
60
Toxicology and carcinogenesis studies of o-nitrotoluene sulfone (CAS no. 88-72-2) in F344/N rats and B6C3F(1) mice (feed studies). 38
12087420 2002
61
The mode of tumour progression in combined hepatocellular carcinoma and cholangiocarcinoma: an immunohistochemical analysis of E-cadherin, alpha-catenin and beta-catenin. 38
11906618 2002
62
Combined hepatocellular carcinoma and cholangiocarcinoma growing into the common bile duct. 38
11777213 2001
63
Primary liver carcinoma in genetic hemochromatosis reveals a broad histologic spectrum. 38
11710692 2001
64
Two-year toxicity and carcinogenicity study of methyleugenol in F344/N rats and B6C3F(1) mice. 38
10956160 2000
65
NTP Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). 38
12563349 2000
66
A resected case of combined hepatocellular carcinoma and cholangiocarcinoma associated with cystic formation. 38
10919046 2000
67
Combined hepatocellular carcinoma and cholangiocarcinoma with high F-18 fluorodeoxyglucose positron emission tomographic uptake. 38
10232488 1999
68
Hepatobiliary malignancies. Primary hepatic malignant neoplasms. 38
10073181 1999
69
Liver carcinoma in PiZ alpha-1-antitrypsin deficiency. 38
9630182 1998
70
Fine needle aspiration diagnosis of combined hepatocellular carcinoma and cholangiocarcinoma. A case report. 38
9990256 1997
71
Combined hepatocellular carcinoma and cholangiocarcinoma in a mare. 38
9179754 1997
72
Expression of intercellular adhesion molecule 1 in human hepatocellular carcinoma. 38
7489978 1995
73
Expression of CD44 in human hepatocellular carcinoma cell lines. 38
7537711 1995
74
CAN IMMUNOHISTOCHEMISTRY DISTINGUISH BETWEEN PRIMARY AND METASTATIC HEPATIC CARCINOMA? 38
28769266 1995
75
Combined hepatocellular carcinoma and cholangiocarcinoma: clinical features and computed tomographic findings. 38
7693572 1993
76
[Hepatocholangiocarcinoma]. 38
7975626 1993
77
Immunohistochemistry in the differential diagnosis of liver carcinomas. 38
1847609 1991
78
Immunohistochemical characterization of 130 cases of primary hepatic carcinomas. 38
2449680 1987
79
Establishment and characterization of a human combined hepatocholangiocarcinoma cell line and its heterologous transplantation in nude mice. 38
3032760 1987
80
[Hepatocholangiocarcinoma associated with renal clear cell carcinoma]. 38
3035626 1987
81
Opisthorchis viverrini infection and cholangiocarcinoma. A prospective, case-controlled study. 38
2989071 1985
82
Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. 38
4007848 1985
83
Hepatic carcinoma with opisthorchiasis. 38
214874 1978
84
[Angiographic study of the vascularization of primary malignant tumors of the liver: histological correlation]. 38
878825 1977

Variations for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Expression for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Search GEO for disease gene expression data for Combined Hepatocellular Carcinoma and Cholangiocarcinoma.

Pathways for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

GO Terms for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Sources for Combined Hepatocellular Carcinoma and Cholangiocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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