Aliases & Classifications for Comedo Carcinoma

MalaCards integrated aliases for Comedo Carcinoma:

Name: Comedo Carcinoma 12 15
Comedocarcinoma 12 74
High Grade Ductal Breast Carcinoma in Situ 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5670
NCIt 51 C4188
SNOMED-CT 69 36425007

Summaries for Comedo Carcinoma

Disease Ontology : 12 A ductal carcinoma in situ that is characterized by the presence of comedo-type of tumor cell necrosis in which the necrotic areas are surrounded by a solid proliferation of malignant pleomorphic cells.

MalaCards based summary : Comedo Carcinoma, also known as comedocarcinoma, is related to in situ carcinoma and adenocarcinoma. An important gene associated with Comedo Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Signaling by ERBB4 and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Tamoxifen and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and prostate, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Wikipedia : 77 Comedocarcinoma is one kind of breast cancer which is most commonly very early-stage which demonstrates... more...

Related Diseases for Comedo Carcinoma

Diseases related to Comedo Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 29.9 ERBB2 ESR1
2 adenocarcinoma 10.1
3 leigh syndrome with leukodystrophy 10.0 NDUFS3 NDUFS4
4 glassy cell carcinoma of the cervix 10.0 ERBB2 ESR1
5 breast medullary carcinoma 10.0 ERBB2 ESR1
6 breast scirrhous carcinoma 10.0 ERBB2 ESR1
7 progesterone-receptor positive breast cancer 10.0 ERBB2 ESR1
8 apocrine adenocarcinoma 10.0 ERBB2 ESR1
9 breast adenoid cystic carcinoma 10.0 ERBB2 ESR1
10 inflammatory breast carcinoma 10.0 ERBB2 ESR1
11 luminal breast carcinoma 10.0 ERBB2 ESR1
12 lobular neoplasia 10.0 ERBB2 ESR1
13 breast benign neoplasm 10.0 ERBB2 ESR1
14 thoracic benign neoplasm 10.0 ERBB2 ESR1
15 uterine corpus cancer 10.0 ERBB2 ESR1
16 lipid-rich carcinoma 10.0 ERBB2 ESR1
17 hidradenocarcinoma 10.0 ERBB2 ESR1
18 mammary paget's disease 9.9 ERBB2 ESR1
19 tubular adenocarcinoma 9.9 ERBB2 ESR1
20 pre-malignant neoplasm 9.9 ERBB2 ESR1
21 fallopian tube carcinoma 9.9 ERBB2 ESR1
22 estrogen-receptor negative breast cancer 9.9 ERBB2 ESR1
23 breast fibroadenoma 9.9 ERBB2 ESR1
24 breast carcinoma in situ 9.9 ERBB2 ESR1
25 malignant ovarian surface epithelial-stromal neoplasm 9.9 ERBB2 ESR1
26 ovary epithelial cancer 9.9 ERBB2 ESR1
27 female breast cancer 9.9 ERBB2 ESR1
28 cervical adenocarcinoma 9.9 ERBB2 ESR1
29 estrogen-receptor positive breast cancer 9.9 ERBB2 ESR1
30 sweat gland cancer 9.9 ERBB2 ESR1
31 uterine anomalies 9.9 ERBB2 ESR1
32 sporadic breast cancer 9.9 ERBB2 ESR1
33 ductal carcinoma in situ 9.9 ERBB2 ESR1
34 female reproductive system disease 9.8 ERBB2 ESR1
35 reproductive system disease 9.8 ERBB2 ESR1
36 gonadal disease 9.8 ERBB2 ESR1
37 endometrial adenocarcinoma 9.8 ERBB2 ESR1
38 breast ductal carcinoma 9.7 ERBB2 ESR1
39 endocrine gland cancer 9.7 ERBB2 ESR1
40 breast adenocarcinoma 9.6 ERBB2 ESR1

Graphical network of the top 20 diseases related to Comedo Carcinoma:



Diseases related to Comedo Carcinoma

Symptoms & Phenotypes for Comedo Carcinoma

GenomeRNAi Phenotypes related to Comedo Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.02 ERBB2 ESR1 HNRNPA1 NDUFS3 NDUFS4

MGI Mouse Phenotypes related to Comedo Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 ERBB2 ESR1 HNMT NDUFS3 NDUFS4

Drugs & Therapeutics for Comedo Carcinoma

Drugs for Comedo Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 3 10540-29-1 2733526
2 Bone Density Conservation Agents Phase 3
3 Estrogen Receptor Antagonists Phase 3
4 Estrogen Antagonists Phase 3
5 Hormones Phase 3
6 Antineoplastic Agents, Hormonal Phase 3
7 Hormone Antagonists Phase 3
8 Selective Estrogen Receptor Modulators Phase 3
9 Estrogens Phase 3
10 Estrogen Receptor Modulators Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia Active, not recruiting NCT01357772 Phase 3 Tamoxifen;placebo
2 Energy Balance and Breast Cancer Aspects-II Recruiting NCT02240836 Not Applicable

Search NIH Clinical Center for Comedo Carcinoma

Genetic Tests for Comedo Carcinoma

Anatomical Context for Comedo Carcinoma

MalaCards organs/tissues related to Comedo Carcinoma:

42
Breast, Bone, Prostate

Publications for Comedo Carcinoma

Articles related to Comedo Carcinoma:

# Title Authors Year
1
Surface topography and ultrastructure correlation between human breast infiltrating ductal carcinoma of non special type and coexisting human breast infiltrating ductal carcinoma of non special type with in situ comedo carcinoma. ( 17472243 )
2003
2
Ultrastructure of the periductal area of comedo carcinoma in situ of the breast. ( 11508833 )
2001
3
Radiological case of the month. Comedocarcinoma. ( 1655694 )
1991
4
Prostatic comedocarcinoma: correlation of sonograms with pathologic specimens in three cases. ( 2164763 )
1990
5
Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma. ( 2837590 )
1988
6
Comedocarcinoma as symmetrical cuirass cancer in the mammary glands of a female boxer. ( 6100420 )
1984
7
Electron microscope observation of viruslike particles in comedocarcinoma of the human breast. ( 4356479 )
1973
8
COMEDOCARCINOMA of the breast. ( 13316747 )
1956
9
Comedocarcinoma of the breast. ( 14373381 )
1955

Variations for Comedo Carcinoma

Cosmic variations for Comedo Carcinoma:

9 (show all 44)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6005476 ZFHX3 breast,NS,carcinoma in situ,ductal carcinoma in situ c.2403A>T p.K801N 16:72957743-72957743 0
2 COSM10701 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.824G>T p.C275F 17:7673796-7673796 0
3 COSM10867 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.797G>A p.G266E 17:7673823-7673823 0
4 COSM10656 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.742C>T p.R248W 17:7674221-7674221 0
5 COSM44415 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.711G>C p.M237I 17:7674252-7674252 0
6 COSM44737 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.860A>G p.E287G 17:7673760-7673760 0
7 COSM6932 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.733G>A p.G245S 17:7674230-7674230 0
8 COSM10662 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.743G>A p.R248Q 17:7674220-7674220 0
9 COSM10779 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.818G>T p.R273L 17:7673802-7673802 0
10 COSM43559 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.517G>T p.V173L 17:7675095-7675095 0
11 COSM43714 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.836G>A p.G279E 17:7673784-7673784 0
12 COSM44901 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.532C>G p.H178D 17:7675080-7675080 0
13 COSM10660 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.818G>A p.R273H 17:7673802-7673802 0
14 COSM43814 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.587G>C p.R196P 17:7674944-7674944 0
15 COSM11089 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.584T>C p.I195T 17:7674947-7674947 0
16 COSM6906973 SMARCA4 breast,NS,carcinoma in situ,ductal carcinoma in situ c.1111G>T p.E371* 19:10987917-10987917 0
17 COSM6906974 PPP2R1A breast,NS,carcinoma in situ,ductal carcinoma in situ c.510C>A p.F170L 19:52212692-52212692 0
18 COSM760 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.1624G>A p.E542K 3:179218294-179218294 0
19 COSM12458 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.1634A>C p.E545A 3:179218304-179218304 0
20 COSM775 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.3140A>G p.H1047R 3:179234297-179234297 0
21 COSM776 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.3140A>T p.H1047L 3:179234297-179234297 0
22 COSM763 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.1633G>A p.E545K 3:179218303-179218303 0
23 COSM774 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.3139C>T p.H1047Y 3:179234296-179234296 0
24 COSM754 PIK3CA breast,NS,carcinoma in situ,ductal carcinoma in situ c.1035T>A p.N345K 3:179203765-179203765 0
25 COSM580 NRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.181C>A p.Q61K 1:114713909-114713909 0
26 COSM565 NRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.35G>C p.G12A 1:114716126-114716126 0
27 COSM6057047 NOTCH1 breast,NS,carcinoma in situ,ductal carcinoma in situ c.7372C>T p.P2458S 9:136496367-136496367 0
28 COSM6005481 MAP2K2 breast,NS,carcinoma in situ,ductal carcinoma in situ c.931G>T p.D311Y 19:4097332-4097332 0
29 COSM521 KRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.35G>A p.G12D 12:25245350-25245350 0
30 COSM532 KRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.38G>A p.G13D 12:25245347-25245347 0
31 COSM516 KRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.34G>T p.G12C 12:25245351-25245351 0
32 COSM520 KRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.35G>T p.G12V 12:25245350-25245350 0
33 COSM1179671 KMT2C breast,NS,carcinoma in situ,ductal carcinoma in situ c.925C>T p.P309S 7:152273792-152273792 0
34 COSM4595028 KMT2C breast,NS,carcinoma in situ,ductal carcinoma in situ c.2681G>A p.R894Q 7:152235905-152235905 0
35 COSM6057048 HRAS breast,NS,carcinoma in situ,ductal carcinoma in situ c.148A>G p.T50A 11:533908-533908 0
36 COSM6906971 H3F3A breast,NS,carcinoma in situ,ductal carcinoma in situ c.218G>A p.R73Q 1:226065745-226065745 0
37 COSM48358 ERBB2 breast,NS,carcinoma in situ,ductal carcinoma in situ c.929C>T p.S310F 17:39711955-39711955 0
38 COSM14060 ERBB2 breast,NS,carcinoma in situ,ductal carcinoma in situ c.2264T>C p.L755S 17:39723967-39723967 0
39 COSM19786 CDH1 breast,NS,carcinoma in situ,ductal carcinoma in situ c.779C>T p.P260L 16:68810288-68810288 0
40 COSM6057049 AKT1 breast,NS,carcinoma in situ,ductal carcinoma in situ c.61A>G p.T21A 14:104780202-104780202 0
41 COSM33765 AKT1 breast,NS,carcinoma in situ,ductal carcinoma in situ c.49G>A p.E17K 14:104780214-104780214 0
42 COSM5174142 breast,NS,carcinoma in situ,ductal carcinoma in situ c.884C>T p.S295F 17:39711955-39711955 0
43 COSM6906972 breast,NS,carcinoma in situ,ductal carcinoma in situ c.1111G>T p.E371* 19:10987917-10987917 0
44 COSM6964823 breast,NS,carcinoma in situ,ductal carcinoma in situ c.659C>T p.T220M 1:39897898-39897898 0

Expression for Comedo Carcinoma

Search GEO for disease gene expression data for Comedo Carcinoma.

Pathways for Comedo Carcinoma

GO Terms for Comedo Carcinoma

Cellular components related to Comedo Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain GO:0070469 8.96 NDUFS3 NDUFS4
2 mitochondrial respiratory chain complex I GO:0005747 8.62 NDUFS3 NDUFS4

Biological processes related to Comedo Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.32 ERBB2 ESR1
2 mitochondrial respiratory chain complex I assembly GO:0032981 9.26 NDUFS3 NDUFS4
3 positive regulation of fibroblast proliferation GO:0048146 9.16 ESR1 NDUFS4
4 mitochondrial electron transport, NADH to ubiquinone GO:0006120 8.96 NDUFS3 NDUFS4
5 reactive oxygen species metabolic process GO:0072593 8.62 NDUFS3 NDUFS4

Molecular functions related to Comedo Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 ERBB2 ESR1
2 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.96 NDUFS3 NDUFS4
3 oxidoreductase activity, acting on NAD(P)H GO:0016651 8.62 NDUFS3 NDUFS4

Sources for Comedo Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....