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MCID: CMD001
MIFTS: 38

Comedo Carcinoma

Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Comedo Carcinoma

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MalaCards integrated aliases for Comedo Carcinoma:

Name: Comedo Carcinoma 12 15
Comedocarcinoma 12 70
High Grade Ductal Breast Carcinoma in Situ 70

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5670
NCIt 50 C4188
SNOMED-CT 67 36425007
UMLS 70 C0334370 C1334002
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Summaries for Comedo Carcinoma

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Disease Ontology : 12 A ductal carcinoma in situ that is characterized by the presence of comedo-type of tumor cell necrosis in which the necrotic areas are surrounded by a solid proliferation of malignant pleomorphic cells.

MalaCards based summary : Comedo Carcinoma, also known as comedocarcinoma, is related to lobular neoplasia and in situ carcinoma. An important gene associated with Comedo Carcinoma is LCOR (Ligand Dependent Nuclear Receptor Corepressor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include breast, ovary and cervix, and related phenotype is integument.

Wikipedia : 73 Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central... more...

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Related Diseases for Comedo Carcinoma

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Diseases related to Comedo Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 lobular neoplasia 29.7 TP53 PGR ESR1 ERBB2
2 in situ carcinoma 29.6 TP53 PGR LCOR ESR1 ERBB2
3 ductal carcinoma in situ 29.6 TP53 PGR ESR1 ERBB2
4 scirrhous adenocarcinoma 10.3 PGR ERBB2
5 lipid-rich breast carcinoma 10.3 PGR ERBB2
6 luminal breast carcinoma b 10.3 PGR ERBB2
7 breast mucinous carcinoma 10.3 PGR ERBB2
8 benign breast phyllodes tumor 10.3 PGR LCOR
9 gastric diffuse adenocarcinoma 10.3 PGR ERBB2
10 bartholin's gland adenoid cystic carcinoma 10.3 PGR ESR1
11 linitis plastica 10.3 PGR ERBB2
12 uterine corpus adenosarcoma 10.3 PGR ESR1
13 chronic tympanitis 10.3 PGR ESR1
14 granulomatous endometritis 10.3 PGR ESR1
15 endometritis 10.3 PGR ESR1
16 vulvar syringoma 10.3 PGR ESR1
17 lung leiomyoma 10.2 PGR ESR1
18 triple-receptor negative breast cancer 10.2 PGR ERBB2
19 adult type testicular granulosa cell tumor 10.2 PGR ESR1
20 breast papillomatosis 10.2 PGR ERBB2
21 liver leiomyoma 10.2 PGR ESR1
22 intravenous leiomyomatosis 10.2 PGR ESR1
23 intracranial meningioma 10.2 PGR ESR1
24 vulvar leiomyoma 10.2 PGR ESR1
25 breast adenoma 10.2 PGR ESR1
26 prostate stromal sarcoma 10.2 PGR ESR1
27 gender identity disorder 10.2 PGR ESR1
28 progesterone resistance 10.2 PGR ESR1
29 biphasic synovial sarcoma 10.2 PGR ESR1
30 juvenile nasopharyngeal angiofibroma 10.2 PGR ESR1
31 trigonitis 10.2 PGR ESR1
32 vaginal discharge 10.2 PGR ESR1
33 vulvar benign neoplasm 10.2 PGR ESR1
34 ovarian endometrial cancer 10.2 PGR ESR1
35 gastric papillary adenocarcinoma 10.2 TP53 ERBB2
36 estrogen excess 10.2 PGR ESR1
37 breast squamous cell carcinoma 10.2 TP53 ERBB2
38 parotid gland cancer 10.2 TP53 ERBB2
39 basaloid lung carcinoma 10.2 TP53 PGR
40 pleomorphic adenoma carcinoma 10.2 TP53 ERBB2
41 esophageal adenosquamous carcinoma 10.2 TP53 ERBB2
42 localized osteosarcoma 10.2 TP53 ERBB2
43 ovarian carcinosarcoma 10.2 TP53 ERBB2
44 endometriosis of ovary 10.1 PGR ESR1
45 cervical adenoma malignum 10.1 TP53 PGR
46 granulosa cell tumor of the ovary 10.1 TP53 ERBB2
47 peritoneal serous adenocarcinoma 10.1 TP53 PGR
48 large intestine adenocarcinoma 10.1 TP53 ERBB2
49 endometrial disease 10.1 PGR ESR1
50 malignant spiradenoma 10.1 TP53 PGR

Graphical network of the top 20 diseases related to Comedo Carcinoma:



Diseases related to Comedo Carcinoma
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Symptoms & Phenotypes for Comedo Carcinoma

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MGI Mouse Phenotypes related to Comedo Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 ERBB2 ESR1 LXN MAP3K11 PGR TP53
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Drugs & Therapeutics for Comedo Carcinoma

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Search Clinical Trials , NIH Clinical Center for Comedo Carcinoma

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Genetic Tests for Comedo Carcinoma

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Anatomical Context for Comedo Carcinoma

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MalaCards organs/tissues related to Comedo Carcinoma:

40
Breast, Ovary, Cervix, Lung, Prostate, Lymph Node, Bone
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Publications for Comedo Carcinoma

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Articles related to Comedo Carcinoma:

(show top 50) (show all 135)
# Title Authors PMID Year
1
Prognostic significance of morphological patterns of Gleason grade 5 prostatic adenocarcinoma diagnosed on needle biopsy. 61
33386122 2021
2
Pure Ductal Carcinoma in Situ in The Male Breast: A Rare Entity. 61
31912019 2020
3
Histopathological Prognostic Factors for Colic Adenocarcinoma. 61
30746162 2018
4
Comparative histopathology and immunohistochemistry of human and canine mammary tumors. 61
30105215 2018
5
Prognostic Significance of Canine Mammary Tumor Histologic Subtypes: An Observational Cohort Study of 229 Cases. 61
28355108 2017
6
Histopathological Study on Conservatively Operated Breast Carcinomas. 61
30581581 2016
7
Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases. 61
26111977 2015
8
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists. 61
25929349 2015
9
Diagnostic evaluation of ductal carcinoma in situ of the breast: ultrasonographic, mammographic and histopathologic correlations. 61
25479813 2015
10
Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy: frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system. 61
25228336 2014
11
Immunohistochemical vascular factor expression in canine inflammatory mammary carcinoma. 61
24048323 2014
12
Mitochondrial D-loop mutations and polymorphisms are connected with canine malignant cancers. 61
23656294 2014
13
Analysis of a new histological and molecular-based classification of canine mammary neoplasia. 61
24003019 2014
14
Local recurrence after ductal carcinoma in situ breast conserving treatment. Analysis of 195 cases. 61
23538041 2013
15
Our orientation regarding the ductal carcinoma in situ of the breast. 61
23110914 2012
16
Ultrasonographic detection and characterization of asymptomatic ductal carcinoma in situ with histopathologic correlation. 61
21498298 2011
17
Predictors of local recurrence in a population-based cohort of women with ductal carcinoma in situ treated with breast conserving surgery alone. 61
20645008 2011
18
Ductal carcinoma in situ of the breast in younger women: a subgroup of patients at high risk. 61
20889280 2010
19
Expression of E-Cadherin in breast carcinomas and its association with other biological markers - a prospective study. 61
22930617 2010
20
Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX. 61
19291713 2009
21
Ductal carcinoma in situ of the breast: our experience. 61
19351465 2009
22
[Ductal carcinoma in situ of the breast (DCIS) under 40: a specific management?]. 61
18467151 2008
23
In situ and invasive components of mammary adenocarcinoma: comparison of Her-2/neu status. 61
17879632 2007
24
[Salivary duct carcinoma of the sublingual gland--a case report]. 61
16586279 2006
25
Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer. 61
16702375 2006
26
Angiogenic potential of ductal carcinoma in situ (DCIS) of human breast. 61
16324200 2005
27
Histopathological review of sebaceous carcinoma of the eyelid. 61
16008694 2005
28
Mammography of ductal carcinoma in situ of the breast: review of 909 cases with radiographic-pathologic correlations. 61
15797293 2005
29
Intraductal papilloma with "comedo-like" necrosis, a diagnostic pitfall. 61
15494933 2004
30
Prognostic value of morphology and hormone receptor status in breast cancer - a population-based study. 61
15365566 2004
31
Vulvar Paget's disease with underlying adenocarcinoma simulating breast carcinoma: case report and review of the literature. 61
15361217 2004
32
Management of bilateral breast carcinoma: long-term results. 61
15521255 2004
33
[Ductal carcinoma in situ of the breast. Analysis of 882 cases]. 61
15026697 2004
34
Risk of mortality by histologic type of breast cancer among women aged 50 to 79 years. 61
14557212 2003
35
Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. 61
12874759 2003
36
Surface topography and ultrastructure correlation between human breast infiltrating ductal carcinoma of non special type and coexisting human breast infiltrating ductal carcinoma of non special type with in situ comedo carcinoma. 61
17472243 2003
37
Surgical management of ductal carcinoma in situ in Australia in 1995. 61
12534380 2002
38
Detection method and breast carcinoma histology. 61
12209738 2002
39
Extramammary Paget Disease of the Axilla Associated With Comedo-like Apocrine Carcinoma In Situ. 61
12142618 2002
40
Breast-conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers' experience. 61
12095552 2002
41
Differences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older. 61
12101106 2002
42
Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosis. 61
11668470 2001
43
Ultrastructure of the periductal area of comedo carcinoma in situ of the breast. 61
11508833 2001
44
Pathobiologic findings in DCIS of the breast: morphologic features, angiogenesis, HER-2/neu and hormone receptors. 61
11418009 2001
45
[Evaluation of prognostic factors in breast cancer EC I-II and the importance of local recurrence]. 61
16161722 2001
46
An in vitro model of human breast carcinogenesis: epigenetic aspects. 61
11261834 2001
47
Cytopathology of metastatic breast cancer. 61
11899649 2000
48
External beam irradiation plus (192)Ir implant after breast-preserving surgery in women with early breast cancer. 61
11020573 2000
49
Sentinel node biopsy in ductal carcinoma in situ patients. 61
10674443 2000
50
Subclinical ductal carcinoma in situ of the breast: treatment with conservative surgery and radiotherapy. 61
10774571 1999
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Variations for Comedo Carcinoma

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Cosmic variations for Comedo Carcinoma:

9 (show top 50) (show all 369)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149317650 ZFHX3 breast,NS,carcinoma in situ,ductal carcinoma in situ c.2403A>T p.K801N 16:72957743-72957743 6
2 COSM87291166 ZFHX3 breast,NS,carcinoma in situ,ductal carcinoma in situ c.2403A>T p.K801N 16:72957743-72957743 6
3 COSM102041732 ZFHX3 breast,NS,carcinoma in situ,ductal carcinoma in situ c.-23-6778A>T p.? 16:72957743-72957743 6
4 COSM143944147 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.265C>T p.R89W 17:7674221-7674221 6
5 COSM112254852 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.584T>C p.I195T 17:7674947-7674947 6
6 COSM122733862 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.422G>A p.R141H 17:7673802-7673802 6
7 COSM144092525 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.110G>C p.R37P 17:7674944-7674944 6
8 COSM112253807 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.733G>A p.G245S 17:7674230-7674230 6
9 COSM143157019 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.265C>T p.R89W 17:7674221-7674221 6
10 COSM111766786 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.587G>C p.R196P 17:7674944-7674944 6
11 COSM144652630 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.467T>C p.I156T 17:7674947-7674947 6
12 COSM144650760 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.701G>A p.R234H 17:7673802-7673802 6
13 COSM121875541 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.422G>A p.R141H 17:7673802-7673802 6
14 COSM144092363 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.359G>A p.G120E 17:7673784-7673784 6
15 COSM142837551 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.742C>T p.R248W 17:7674221-7674221 6
16 COSM122734399 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.346C>T p.R116W 17:7674221-7674221 6
17 COSM87900157 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.818G>T p.R273L 17:7673802-7673802 6
18 COSM105621872 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.584T>C p.I195T 17:7674947-7674947 6
19 COSM106053434 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.742C>T p.R248W 17:7674221-7674221 6
20 COSM144015040 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.785G>T p.R262L 17:7673802-7673802 6
21 COSM93185256 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.818G>T p.R273L 17:7673802-7673802 6
22 COSM93190437 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.517G>T p.V173L 17:7675095-7675095 6
23 COSM145017944 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.625C>T p.R209W 17:7674221-7674221 6
24 COSM111758868 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.742C>T p.R248W 17:7674221-7674221 6
25 COSM142837352 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.743G>A p.R248Q 17:7674220-7674220 6
26 COSM144087106 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.266G>A p.R89Q 17:7674220-7674220 6
27 COSM145018679 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.707G>T p.C236F 17:7673796-7673796 6
28 COSM121876459 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.346C>T p.R116W 17:7674221-7674221 6
29 COSM93191567 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.587G>C p.R196P 17:7674944-7674944 6
30 COSM144048390 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.678G>C p.M226I 17:7674252-7674252 6
31 COSM142837497 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.733G>A p.G245S 17:7674230-7674230 6
32 COSM144651436 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.625C>T p.R209W 17:7674221-7674221 6
33 COSM105667399 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.711G>C p.M237I 17:7674252-7674252 6
34 COSM144013367 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.710G>A p.R237Q 17:7674220-7674220 6
35 COSM144026584 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.499C>G p.H167D 17:7675080-7675080 6
36 COSM112253879 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.742C>T p.R248W 17:7674221-7674221 6
37 COSM143378524 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.719G>A p.G240E 17:7673784-7673784 6
38 COSM111759630 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.797G>A p.G266E 17:7673823-7673823 6
39 COSM142560553 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.625C>T p.R209W 17:7674221-7674221 6
40 COSM143945376 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.341G>T p.R114L 17:7673802-7673802 6
41 COSM142866376 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.711G>C p.M237I 17:7674252-7674252 6
42 COSM93183281 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.818G>A p.R273H 17:7673802-7673802 6
43 COSM143156843 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.266G>A p.R89Q 17:7674220-7674220 6
44 COSM111797204 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.711G>C p.M237I 17:7674252-7674252 6
45 COSM87898709 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.742C>T p.R248W 17:7674221-7674221 6
46 COSM105620276 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.743G>A p.R248Q 17:7674220-7674220 6
47 COSM122748281 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.136C>G p.H46D 17:7675080-7675080 6
48 COSM106067001 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.532C>G p.H178D 17:7675080-7675080 6
49 COSM145024750 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.400G>T p.V134L 17:7675095-7675095 6
50 COSM144014340 TP53 breast,NS,carcinoma in situ,ductal carcinoma in situ c.791G>T p.C264F 17:7673796-7673796 6
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Expression for Comedo Carcinoma

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Search GEO for disease gene expression data for Comedo Carcinoma.
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Pathways for Comedo Carcinoma

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Pathways related to Comedo Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 36
Show member pathways
 11.92 TP53 PGR ESR1 ERBB2
2
Development Ligand-independent activation of ESR1 and ESR2 23
Show member pathways
 11.76 MAP3K11 ESR1 ERBB2
3
Proteoglycans in cancer 36
11.64 TP53 ESR1 ERBB2
4
Ovarian tumor domain proteases 65
10.94 TP53 ESR1
5
Signaling mediated by p38-alpha and p38-beta 1
10.87 TP53 ESR1
6
Signaling by ERBB4 65
Show member pathways
 10.83 PGR ESR1 ERBB2
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GO Terms for Comedo Carcinoma

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Biological processes related to Comedo Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to estradiol stimulus GO:0071392 9.32 LCOR ESR1
2 steroid hormone mediated signaling pathway GO:0043401 9.26 PGR ESR1
3 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.16 TP53 ESR1
4 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.96 TP53 ESR1
5 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 PGR ESR1

Molecular functions related to Comedo Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 PGR ESR1
2 steroid hormone receptor activity GO:0003707 8.96 PGR ESR1
3 RNA polymerase II transcription corepressor binding GO:0001226 8.62 LCOR ESR1
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Sources for Comedo Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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