MCID: CMM007
MIFTS: 27

Common Bile Duct Disease

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Common Bile Duct Disease

MalaCards integrated aliases for Common Bile Duct Disease:

Name: Common Bile Duct Disease 12 15
Common Bile Duct Diseases 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4137
MeSH 43 D003137
UMLS 71 C0009440

Summaries for Common Bile Duct Disease

MalaCards based summary : Common Bile Duct Disease, also known as common bile duct diseases, is related to cholecystitis and cholangitis. An important gene associated with Common Bile Duct Disease is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways is Folate Metabolism. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder.

Wikipedia : 74 The common bile duct, sometimes abbreviated CBD, is a duct in the gastrointestinal tract of organisms... more...

Related Diseases for Common Bile Duct Disease

Diseases in the Bile Duct Disease family:

Common Bile Duct Disease

Diseases related to Common Bile Duct Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 29.3 GPT F2 CCK ALB
2 cholangitis 29.1 GPT GGT1 F2 CRP CEACAM5 ALB
3 bile duct disease 28.2 PRRT2 PCCA GPT GGTLC3 GGT2 GGT1
4 dipetalonemiasis 10.5 GPT ALB
5 intestinal tuberculosis 10.5 CRP ALB
6 external ear carcinoma 10.4 CRP CEACAM5
7 heterophyiasis 10.4 GPT ALB
8 hepatoportal sclerosis 10.4 GPT F2
9 tinea unguium 10.4 GPT CRP
10 pericardial tuberculosis 10.4 CRP CEACAM5
11 chronic duodenal ileus 10.4 CRP ALB
12 bile duct rhabdomyosarcoma 10.4 GGTLC3 GGT2 GGT1
13 splenic tuberculosis 10.4 GGTLC3 GGT2 GGT1
14 perforation of bile duct 10.4 GGTLC3 GGT2 GGT1
15 achenbach syndrome 10.4 F2 CRP
16 orbital osteomyelitis 10.4 F2 CRP
17 small intestine diverticulitis 10.4 F2 CRP
18 optic nerve astrocytoma 10.4 GGTLC3 GGT2 GGT1
19 myasthenic syndrome, congenital, 3b, fast-channel 10.4 GGTLC3 GGT2 GGT1
20 dientamoebiasis 10.4 GGTLC3 GGT2 GGT1
21 algoneurodystrophy 10.4 GGTLC3 GGT2 GGT1
22 glutathionuria 10.4 GGTLC3 GGT2 GGT1
23 pyridoxine deficiency anemia 10.4 GPT F2
24 noonan syndrome 8 10.4 GGTLC3 GGT2 GGT1
25 amelogenesis imperfecta, type if 10.4 GGTLC3 GGT2 GGT1
26 familial adenomatous polyposis 2 10.4 GGTLC3 GGT2 GGT1
27 giant axonal neuropathy 1, autosomal recessive 10.4 GGTLC3 GGT2 GGT1
28 synovial angioma 10.4 F2 CRP
29 cataract 34, multiple types 10.4 GGTLC3 GGT2 GGT1
30 renal pelvis squamous cell carcinoma 10.4 F2 CRP
31 blue toe syndrome 10.4 F2 CRP
32 peptic ulcer perforation 10.4 CRP ALB
33 loeys-dietz syndrome 2 10.4 GGTLC3 GGT2 GGT1
34 loeys-dietz syndrome 10.4 GGTLC3 GGT2 GGT1
35 hematocele of tunica vaginalis testis 10.4 F2 CRP
36 cataract 4, multiple types 10.4 GGTLC3 GGT2 GGT1
37 contractural arachnodactyly, congenital 10.4 GGTLC3 GGT2 GGT1
38 sarcomatous intrahepatic cholangiocarcinoma 10.4 GPT CEACAM5
39 extrahepatic cholestasis 10.4 GPT GGT1 ABCB4
40 cavernous sinus thrombosis 10.4 F2 CRP
41 lemierre's syndrome 10.4 F2 CRP
42 meningovascular neurosyphilis 10.3 CRP ALB
43 non-a-e hepatitis 10.3 F2 ALB
44 antipyrine metabolism 10.3 F2 ALB
45 intracranial sinus thrombosis 10.3 F2 CRP
46 bronchiectasis 1 10.3 LIX1 CRP
47 critical illness polyneuropathy 10.3 GPT CRP ALB
48 fournier gangrene 10.3 F2 ALB
49 heart aneurysm 10.3 GPT CRP ALB
50 coronary aneurysm 10.3 GPT CRP ALB

Graphical network of the top 20 diseases related to Common Bile Duct Disease:



Diseases related to Common Bile Duct Disease

Symptoms & Phenotypes for Common Bile Duct Disease

Drugs & Therapeutics for Common Bile Duct Disease

Drugs for Common Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 3 51-41-2 439260
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
Diclofenac Approved, Vet_approved Phase 2, Phase 3 15307-86-5 3033
4 Dopamine Agents Phase 3
5 Neurotransmitter Agents Phase 3
6 Antidepressive Agents Phase 3
7 Psychotropic Drugs Phase 3
8 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
9 Duloxetine Hydrochloride Phase 3
10 Analgesics, Non-Narcotic Phase 2, Phase 3
11 Analgesics Phase 2, Phase 3
12 Cyclooxygenase Inhibitors Phase 2, Phase 3
13 Antirheumatic Agents Phase 2, Phase 3
14 Anti-Inflammatory Agents Phase 2, Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
16
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Digital SpyGlass Cholangioscopy Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
2 Pilot Study of the Efficacy and Tolerability of Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction). Completed NCT00471315 Phase 3 Duloxetine
3 Diclofenac for Prevention of Post-ERC Pancreatitis Not yet recruiting NCT03595150 Phase 2, Phase 3 Diclofenac
4 Comparison of Iatrogenic Common Bile Duct Injuries Following Open Cholecystectomy vs Laparoscopic Cholecystectomy Unknown status NCT00840138
5 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Trial " EASYSPY " Active, not recruiting NCT03190343
6 Early Precut Sphincterotomy During ERCP With Difficult Biliary Access (Italian: Esecuzione Del Pre-cut Precoce in Corso di ERCP Con Difficoltosa Incannulazione Della Via Biliare) Terminated NCT02596646

Search NIH Clinical Center for Common Bile Duct Disease

Cochrane evidence based reviews: common bile duct diseases

Genetic Tests for Common Bile Duct Disease

Anatomical Context for Common Bile Duct Disease

Publications for Common Bile Duct Disease

Articles related to Common Bile Duct Disease:

(show all 22)
# Title Authors PMID Year
1
Effect of p38 mitogen-activate protein kinase on MUC5AC protein expression of bile duct epithelial cells in hepatolithiasis patients. 61
26722604 2015
2
[Percutaneous endoscopic cholangioscopy (percutaneous cholangioscopy)]. 61
15560566 2004
3
[Peroral cholangioscopy]. 61
15332645 2004
4
Endolaparoscopic rendezvous treatment: a satisfying therapeutic choice for cholecystocholedocolithiasis. 61
11972193 2002
5
Percutaneous cholangioscopy in the management of biliary disease: experience in 25 patients. 61
11232890 2000
6
Endoscopic retrograde cholangiopancreatography in elderly patients. 61
10408661 1998
7
Hepatobiliary disease in cystic fibrosis patients with pancreatic sufficiency. 61
7535738 1995
8
[Choledochoduodenostomy in the treatment of benign disease of the common bile duct: evaluation of long-term results]. 61
7547119 1995
9
[Percutaneous transhepatic cholangioscopy as a single-step technique]. 61
1950035 1991
10
Operative cholangiography. 61
2316802 1990
11
Peroral cholangioscopy--an improved method in the diagnosis of common bile duct diseases. 61
2792678 1989
12
Operative therapy of gallbladder disease in patients with cystic fibrosis. 61
2729516 1989
13
Rigid or flexible choledochoscopy? 61
4065050 1985
14
In vivo measurements of the internal and external diameters of the common bile duct in man. 61
7221849 1981
15
Is intravenous cholangiography still useful? 61
7409384 1980
16
[Biliary lithiasis in patients aged over 70 years: considerations on 125 operations]. 61
7225149 1980
17
The relationship between biliary tract infections and postoperative complications. 61
341378 1978
18
[Diagnosis and surgical management of cholecystitis complicated by common bile duct diseases]. 61
633759 1978
19
Radiomanometry in the diagnosis of common bile duct disease. 61
4445925 1974
20
[Serum enzyme and isoenzyme changes in acute common bile duct diseases]. 61
4144178 1973
21
Radiomanometry, flow rates, and cholangiography in the evaluation of common bile duct disease. A study of 220 cases. 61
5058873 1972
22
The incidence of common bile duct disease following surgical exploration. 61
14352652 1955

Variations for Common Bile Duct Disease

Expression for Common Bile Duct Disease

Search GEO for disease gene expression data for Common Bile Duct Disease.

Pathways for Common Bile Duct Disease

Pathways related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 GGT2 GGT1 F2 CRP ALB

GO Terms for Common Bile Duct Disease

Cellular components related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.28 STK10 GPT GGTLC3 GGT2 GGT1 F2

Biological processes related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune system process GO:0002682 9.26 GGT2 GGT1
2 peptide modification GO:0031179 9.16 GGT2 GGT1
3 glutathione catabolic process GO:0006751 9.13 GGTLC3 GGT2 GGT1
4 leukotriene D4 biosynthetic process GO:1901750 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Common Bile Duct Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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