Common Bile Duct Disease

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Common Bile Duct Disease

MalaCards integrated aliases for Common Bile Duct Disease:

Name: Common Bile Duct Disease 12 15
Common Bile Duct Diseases 45 74


External Ids:

Disease Ontology 12 DOID:4137
MeSH 45 D003137
UMLS 74 C0009440

Summaries for Common Bile Duct Disease

MalaCards based summary : Common Bile Duct Disease, also known as common bile duct diseases, is related to bile duct disease and biliary dyskinesia. An important gene associated with Common Bile Duct Disease is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Eicosanoid Synthesis. The drugs Pinaverium and Morphine have been mentioned in the context of this disorder. Affiliated tissues include liver and pancreas.

Wikipedia : 77 The common bile duct, sometimes abbreviated CBD, is a duct in the gastrointestinal tract of organisms... more...

Related Diseases for Common Bile Duct Disease

Graphical network of the top 20 diseases related to Common Bile Duct Disease:

Diseases related to Common Bile Duct Disease

Symptoms & Phenotypes for Common Bile Duct Disease

Drugs & Therapeutics for Common Bile Duct Disease

Drugs for Common Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Secretin Approved Phase 4 108153-74-8
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
Etomidate Approved Phase 4 33125-97-2 667484 36339
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
9 Calcium, Dietary Phase 4
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
11 Bromides Phase 4
12 Parasympatholytics Phase 4
13 Autonomic Agents Phase 4
14 Hormones Phase 4
15 calcium channel blockers Phase 4
16 Anticonvulsants Phase 4
17 Analgesics Phase 4,Phase 3,Phase 2
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
19 Central Nervous System Depressants Phase 4,Phase 2
20 Psychotropic Drugs Phase 4,Phase 3,Phase 2
21 Tranquilizing Agents Phase 4,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
23 Cholinesterase Inhibitors Phase 4
24 Hormone Antagonists Phase 4
25 Analgesics, Opioid Phase 4
26 Gastrointestinal Agents Phase 4
27 Narcotics Phase 4
28 Cholinergic Agents Phase 4
29 GABA Modulators Phase 4
30 Anti-Anxiety Agents Phase 4
31 Anesthetics, General Phase 4
32 Adjuvants, Anesthesia Phase 4
33 Anesthetics, Intravenous Phase 4
34 Anesthetics Phase 4,Not Applicable
35 Hypnotics and Sedatives Phase 4
36 GABA Agents Phase 4
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
Norepinephrine Approved Phase 3 51-41-2 439260
Diclofenac Approved, Vet_approved Phase 2, Phase 3 15307-86-5 3033
40 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
41 Antidepressive Agents Phase 3,Phase 2
42 Analgesics, Non-Narcotic Phase 2, Phase 3
43 Duloxetine Hydrochloride Phase 3
44 Dopamine Agents Phase 3
45 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
46 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
47 Cyclooxygenase Inhibitors Phase 2, Phase 3
48 Antirheumatic Agents Phase 2, Phase 3
49 Anti-Inflammatory Agents Phase 2, Phase 3
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
3 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
4 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
5 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
6 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
7 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
8 Diclofenac for Prevention of Post-ERC Pancreatitis Not yet recruiting NCT03595150 Phase 2, Phase 3 Diclofenac
9 Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
10 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
11 A Comparison of Bile Duct Injuries Following Open Cholecystectomy Versus Laparoscopic Cholecystectomy Unknown status NCT00840138
12 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Unknown status NCT02276157
13 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
14 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
15 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581 Not Applicable
16 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
17 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
18 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography). Unknown status NCT01414400 Not Applicable
19 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234 Not Applicable
20 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Completed NCT03074201 Not Applicable
21 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686 Not Applicable
22 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475 Not Applicable
23 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979 Not Applicable
24 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method Completed NCT02916199 Not Applicable
25 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
26 Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction Completed NCT00688662 Not Applicable
27 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958 Not Applicable
28 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240 Not Applicable
29 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845 Not Applicable
30 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186 Not Applicable
31 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269 Not Applicable
32 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100 Not Applicable
33 Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy Completed NCT00981604 Not Applicable
34 "Endoscopy First" or "Laparoscopic Cholecystectomy First" for Patients With Intermediate Risk of Choledocholithiasis Recruiting NCT03658863 Not Applicable
35 Papillary Balloon Dilation Versus Laser Lithotripsy Recruiting NCT03536247 Not Applicable
36 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286 Not Applicable
37 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
38 The Clinical Evaluation of Oddi Spincteroplasty With Blood Vessel Clamp After Iatrogenic Injury by ERCP Recruiting NCT03795584 Not Applicable
39 The Comparisons of One-stage and Two-stage Stone Removal in Moderate Cholangitis Recruiting NCT03754491 Not Applicable
40 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453 Not Applicable
41 Effect of Saline Irrigation in Reducing Choledocholithiasis Recurrence After ERCP Recruiting NCT03937037 Not Applicable
42 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
43 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
44 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Active, not recruiting NCT03190343
45 Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis Active, not recruiting NCT02554097
46 Pancreaticoduodenectomy With or Without Preoperative Hyperbaric Oxygen Therapy Enrolling by invitation NCT02575014 Not Applicable Preoperative hyperbaric oxygen
47 Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage Not yet recruiting NCT03921502 Not Applicable
48 Early MRI in Acute GallstonE Disease Not yet recruiting NCT03709030 Not Applicable
49 Early Precut in Difficult Biliary Cannulation Terminated NCT02596646 Not Applicable
50 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846 Not Applicable

Search NIH Clinical Center for Common Bile Duct Disease

Cochrane evidence based reviews: common bile duct diseases

Genetic Tests for Common Bile Duct Disease

Anatomical Context for Common Bile Duct Disease

MalaCards organs/tissues related to Common Bile Duct Disease:

Liver, Pancreas

Publications for Common Bile Duct Disease

Articles related to Common Bile Duct Disease:

# Title Authors Year
Peroral cholangioscopy--an improved method in the diagnosis of common bile duct diseases. ( 2792678 )
Radiomanometry in the diagnosis of common bile duct disease. ( 4445925 )
Radiomanometry, flow rates, and cholangiography in the evaluation of common bile duct disease. A study of 220 cases. ( 5058873 )
The incidence of common bile duct disease following surgical exploration. ( 14352652 )

Variations for Common Bile Duct Disease

Expression for Common Bile Duct Disease

Search GEO for disease gene expression data for Common Bile Duct Disease.

Pathways for Common Bile Duct Disease

Pathways related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
10.8 GGT1 GGT2
2 10.34 GGT1 GGT2
3 9.98 GGT1 GGT2

GO Terms for Common Bile Duct Disease

Cellular components related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 CTSC GGT1 GGT2 GGTLC3 GPT STK10

Biological processes related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.78 CTSC GGT1 GGT2 GGTLC3
2 regulation of inflammatory response GO:0050727 9.51 GGT1 GGT2
3 cellular amino acid metabolic process GO:0006520 9.49 GGT1 GGT2
4 glutathione metabolic process GO:0006749 9.46 GGT1 GGT2
5 response to tumor necrosis factor GO:0034612 9.43 GGT1 GGT2
6 glutamate metabolic process GO:0006536 9.4 GGT1 GGT2
7 zymogen activation GO:0031638 9.37 GGT1 GGT2
8 cysteine biosynthetic process GO:0019344 9.32 GGT1 GGT2
9 regulation of immune system process GO:0002682 9.26 GGT1 GGT2
10 peptide modification GO:0031179 9.16 GGT1 GGT2
11 glutathione catabolic process GO:0006751 9.13 GGT1 GGT2 GGTLC3
12 leukotriene D4 biosynthetic process GO:1901750 8.8 GGT1 GGT2 GGTLC3

Molecular functions related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT1 GGT2
2 glutathione hydrolase activity GO:0036374 8.8 GGT1 GGT2 GGTLC3

Sources for Common Bile Duct Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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