MCID: CMM007
MIFTS: 23

Common Bile Duct Disease

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Common Bile Duct Disease

MalaCards integrated aliases for Common Bile Duct Disease:

Name: Common Bile Duct Disease 12 15
Common Bile Duct Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4137
MeSH 44 D003137
UMLS 73 C0009440

Summaries for Common Bile Duct Disease

MalaCards based summary : Common Bile Duct Disease, also known as common bile duct diseases, is related to bile duct disease and cecal disease. An important gene associated with Common Bile Duct Disease is STK10 (Serine/Threonine Kinase 10). The drugs Pinaverium and Morphine have been mentioned in the context of this disorder. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 The common bile duct, sometimes abbreviated CBD, is a duct in the gastrointestinal tract of organisms... more...

Related Diseases for Common Bile Duct Disease

Diseases related to Common Bile Duct Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 bile duct disease 29.2 CCK GGT2
2 cecal disease 10.3 NODAL STK10
3 postcholecystectomy syndrome 10.3 CCK SOBP
4 cholecystolithiasis 10.2 CCK STK10
5 duodenal disease 10.2 CCK NODAL
6 choledocholithiasis 10.1 CTSC SOBP STK10
7 biliary dyskinesia 10.0 CCK SOBP STK10
8 gallbladder disease 9.6 CCK NODAL
9 biliary tract disease 9.3 CCK GGT2

Graphical network of the top 20 diseases related to Common Bile Duct Disease:



Diseases related to Common Bile Duct Disease

Symptoms & Phenotypes for Common Bile Duct Disease

GenomeRNAi Phenotypes related to Common Bile Duct Disease according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.6 PNLIPRP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.6 NODAL
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 CTSC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 CTSC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.6 NODAL
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.6 NODAL PNLIPRP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 CTSC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.6 CTSC NODAL PNLIPRP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 NODAL
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.6 NODAL
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.6 NODAL
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.6 CTSC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 CTSC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 CTSC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.6 CTSC PNLIPRP1

Drugs & Therapeutics for Common Bile Duct Disease

Drugs for Common Bile Duct Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pinaverium Approved Phase 4 59995-65-2
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
4
Secretin Approved, Investigational Phase 4 108153-74-8
5
Etomidate Approved Phase 4 33125-97-2 36339 667484
6
Meperidine Approved Phase 4,Not Applicable 57-42-1 4058
7
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
8 Anticonvulsants Phase 4
9 Autonomic Agents Phase 4
10 Bromides Phase 4
11 calcium channel blockers Phase 4
12 Calcium, Dietary Phase 4
13 Parasympatholytics Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
15 Analgesics Phase 4,Phase 3,Phase 2
16 Central Nervous System Depressants Phase 4,Phase 2
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2
19 Tranquilizing Agents Phase 4,Phase 2
20 Analgesics, Opioid Phase 4
21 Cholinergic Agents Phase 4
22 Cholinesterase Inhibitors Phase 4
23 Gastrointestinal Agents Phase 4
24 Hormone Antagonists Phase 4
25 Hormones Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
27 Narcotics Phase 4
28 Adjuvants, Anesthesia Phase 4
29 Anesthetics Phase 4
30 Anesthetics, General Phase 4
31 Anesthetics, Intravenous Phase 4
32 Anti-Anxiety Agents Phase 4
33 GABA Agents Phase 4
34 GABA Modulators Phase 4
35 Hypnotics and Sedatives Phase 4
36
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
37
Norepinephrine Approved Phase 3 51-41-2 439260
38 Antidepressive Agents Phase 3,Phase 2
39 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2
40 Dopamine Agents Phase 3
41 Duloxetine Hydrochloride Phase 3
42 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
43
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
44
Amitriptyline Approved Phase 2 50-48-6 2160
45
Perphenazine Approved Phase 2 58-39-9 4748
46 Adrenergic Agents Phase 2
47 Amitriptyline, perphenazine drug combination Phase 2
48 Analgesics, Non-Narcotic Phase 2
49 Antidepressive Agents, Tricyclic Phase 2
50 Antipsychotic Agents Phase 2

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
2 Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla Unknown status NCT02703077 Phase 4
3 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
4 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
5 Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Completed NCT02967926 Phase 3
6 Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction) Completed NCT00471315 Phase 3 Duloxetine
7 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
8 Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Unknown status NCT02195115 Phase 2 amitriptyline
9 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
10 A Comparison of Bile Duct Injuries Following Open Cholecystectomy Versus Laparoscopic Cholecystectomy Unknown status NCT00840138
11 Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope Unknown status NCT02276157
12 The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis Unknown status NCT02647593
13 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147
14 A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation Unknown status NCT00451581 Not Applicable
15 Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering Unknown status NCT00329888
16 Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatogr Unknown status NCT01414400 Not Applicable
17 Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis Unknown status NCT00416234 Not Applicable
18 EUS Guided ERCP in Bile Duct Stone Removal Completed NCT02870686 Not Applicable
19 Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography Completed NCT02594475 Not Applicable
20 Laser Versus Mechanical Lithotripsy of Bile Duct Stones Completed NCT01759979 Not Applicable
21 Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method Completed NCT02916199 Not Applicable
22 Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone Completed NCT00173368
23 Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction Completed NCT00688662 Not Applicable
24 Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy Completed NCT02037958 Not Applicable
25 Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones Completed NCT01683240 Not Applicable
26 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845 Not Applicable
27 Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy Completed NCT01824186 Not Applicable
28 Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD Completed NCT01673269 Not Applicable
29 Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy Completed NCT00984100 Not Applicable
30 Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy Completed NCT00981604 Not Applicable
31 Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases Recruiting NCT03190343
32 Role of EUS in High Risk of Choledocholithiasis Recruiting NCT03250286 Not Applicable
33 Prospective Evaluation of the Ability of Spyglass Cholangioscopy to Facilitate Radiation Free ERCP Recruiting NCT03074201 Not Applicable
34 Comparison of LCBDE vs ERCP + LC for Choledocholithiasis Recruiting NCT02515474 Not Applicable
35 Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP Recruiting NCT02611453 Not Applicable
36 Microbiomes in Patients of Recurrent Common Bile Duct Stones Recruiting NCT03102281
37 Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient Recruiting NCT02958059 Not Applicable
38 Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Recruiting NCT01438385
39 Optimization and Cost-effective Analysis of Secondary Biliary Stones' Managements Enrolling by invitation NCT02554097
40 Pancreaticoduodenectomy With or Without Preoperative Hyperbaric Oxygen Therapy Enrolling by invitation NCT02575014 Not Applicable Preoperative hyperbaric oxygen
41 Papillary Balloon Dilation Versus Laser Lithotripsy Not yet recruiting NCT03536247 Not Applicable
42 Early Precut in Difficult Biliary Cannulation Terminated NCT02596646 Not Applicable
43 Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients Terminated NCT00612846 Not Applicable
44 Evaluation of Gastrointestinal Symptoms and Quality of Life in Patients With Sphincter of Oddi Dysfunction Terminated NCT01410071
45 Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy Terminated NCT01195285 Not Applicable
46 Ultrasound for Diagnosis of Biliary Dyskinesia Terminated NCT00737295 Not Applicable
47 Management of Common Bile Duct (CBD) Stones at Laparoscopic Cholecystectomy Terminated NCT00124033 Not Applicable
48 Prospective Evaluation of the Covered Self-expandable Metal Stents (CSEMS) for Incomplete Biliary Stone Clearance Withdrawn NCT01475864

Search NIH Clinical Center for Common Bile Duct Disease

Cochrane evidence based reviews: common bile duct diseases

Genetic Tests for Common Bile Duct Disease

Anatomical Context for Common Bile Duct Disease

Publications for Common Bile Duct Disease

Articles related to Common Bile Duct Disease:

# Title Authors Year
1
Radiomanometry in the diagnosis of common bile duct disease. ( 4445925 )
1974
2
Radiomanometry, flow rates, and cholangiography in the evaluation of common bile duct disease. A study of 220 cases. ( 5058873 )
1972
3
The incidence of common bile duct disease following surgical exploration. ( 14352652 )
1955

Variations for Common Bile Duct Disease

Expression for Common Bile Duct Disease

Search GEO for disease gene expression data for Common Bile Duct Disease.

Pathways for Common Bile Duct Disease

GO Terms for Common Bile Duct Disease

Sources for Common Bile Duct Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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