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MCID: CMM005
MIFTS: 55

Common Cold

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Common Cold

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MalaCards integrated aliases for Common Cold:

Name: Common Cold 12 73 54 42 3 44 15 17 70
Acute Viral Rhinopharyngitis 12
Nasopharyngitis - Acute 12
Nasopharyngitis, Acute 12
Acute Nasopharyngitis 12
Rhino-Sinusitis 12
Acute Rhinitis 12
Rhinosinusitis 15
Acute Coryza 12
Common Colds 62

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10459
ICD9CM 34 460
MeSH 44 D003139
NCIt 50 C34500
SNOMED-CT 67 195648002
ICD10 32 J00
UMLS 70 C0009443
Sources

Summaries for Common Cold

About this section
MedlinePlus : 42 Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. It is probably the most common illness. In the course of a year, people in the United States suffer 1 billion colds. You can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. You can also inhale the germs. Symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. Washing your hands and staying away from people with colds will help you avoid colds. There is no cure for the common cold. But there are treatments that can make you feel better while you wait for the cold to go away on its own: Getting plenty of rest Drinking fluids Gargling with warm salt water Using cough drops or throat sprays Taking over-the-counter pain or cold medicines However, do not give aspirin to children. And do not give cough medicine to children under four.

MalaCards based summary : Common Cold, also known as acute viral rhinopharyngitis, is related to churg-strauss syndrome and disease by infectious agent, and has symptoms including fever, pruritus and tinnitus. An important gene associated with Common Cold is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefditoren and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and bone, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC : 3 Sore throat and runny nose are usually the first signs of a cold, followed by coughing and sneezing. Most people recover in about 7-10 days. You can help reduce your risk of getting a cold: wash your hands often, avoid close contact with sick people, and don't touch your face with unwashed hands.

PubMed Health : 62 About common colds: Common colds, or simply “colds,” are usually quite harmless and go away again on their own. Symptoms of a cold such as a cough, sore throat and a runny nose can be really annoying. A severe cold can make you feel weak and ill, too. Colds usually go away on their own after about a week, but some symptoms may last longer. Although a sore throat or a stuffy nose may be gone after just a few days, it can sometimes take up to three weeks for a cough to disappear completely. Treatment with medication usually isn’t necessary. Some medications may, at best, help relieve the symptoms a bit. Because colds are typically caused by viruses, it also doesn't make sense to use antibiotics to treat an ordinary cold. Antibiotics only work against bacteria.

Wikipedia : 73 The common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory... more...

Sources

Related Diseases for Common Cold

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Diseases related to Common Cold via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 730)
# Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 32.0 RNASE3 IL5 CXCL8 CCL11
2 disease by infectious agent 31.8 IL4 ICOSLG CCR6 ALB
3 pneumonia 31.6 IL5 IL4 IL13 CXCL8 CCL5 CCL11
4 pulmonary disease, chronic obstructive 31.6 RNASE3 IL5 IL4 IL13 ICOSLG CXCL8
5 viral infectious disease 31.4 IL4 IL13 IFNA2 ICOSLG ICAM1 CXCL8
6 gastroesophageal reflux 31.2 IL5 IL4 CXCL8 CCL11
7 sleep apnea 31.0 ICAM1 CXCL8 ALB
8 bone inflammation disease 30.9 IL4 IL13 ICOSLG ICAM1 CXCL8 CCR6
9 aspergillosis 30.8 IL5 IL4 IL1R1 CXCL8 CCR6 CCL5
10 bacterial infectious disease 30.8 IL1R1 ICOSLG CXCL8 CCR6
11 dacryoadenitis 30.6 IL4 IL13 ICOSLG CCR6
12 otitis media 30.6 RNASE3 IL5 IL4 ICAM1 CXCL8 CCL11
13 acute asthma 30.6 RNASE3 IL5 IL4
14 toxic shock syndrome 30.5 IL4 IL1R1 CXCL8
15 drug allergy 30.5 IL5 IL13 ALB
16 diarrhea 30.5 IL5 IL13 IFNA2 CXCL8 ALB
17 streptococcus pneumonia 30.5 IL4 CXCL8 CCR6 ALB
18 rhinitis 30.5 TSLP RNASE3 IL5 IL4 IL33 IL13
19 exanthem 30.5 ICOSLG CXCL8 CCR6 ALB
20 allergic rhinitis 30.5 RNASE3 IL5 IL4 IL13 ICAM1 CXCL8
21 bronchitis 30.5 RNASE3 IL5 IL4 IL13 CXCL8 CCL5
22 acquired immunodeficiency syndrome 30.5 IFNA2 ICAM1 CCR6 ALB
23 apnea, obstructive sleep 30.5 ICAM1 CXCL8 ALB
24 urticaria 30.5 RNASE3 IL5 IL4 IL13 CXCL8
25 vasomotor rhinitis 30.4 RNASE3 IL5 IL13
26 food allergy 30.4 RNASE3 IL5 IL4 IL13 CXCL8 ALB
27 paranasal sinus disease 30.4 RNASE3 IL5 IL4 IL13 ICOSLG CXCL8
28 sarcoidosis 1 30.4 IL13 ICOSLG ICAM1 CCR6 CCL5 CCL11
29 igg4-related disease 30.4 IL4 IL33 ICOSLG CCR6
30 cellulitis 30.4 RNASE3 IL5 IL1R1 CCR6 ALB
31 vaginitis 30.3 CXCL8 CCR6 CCL5
32 common variable immunodeficiency 30.3 IL5 IL4 IL1R1 ICOSLG
33 immune deficiency disease 30.3 IL4 IL1R1 IL13 ICOSLG CCR6 CCL5
34 cytokine deficiency 30.3 IL5 IL13
35 chronic fatigue syndrome 30.3 IL5 IL4 IL13 CXCL8 CCL5
36 maxillary sinusitis 30.3 SELP RNASE3 CCL5
37 proteasome-associated autoinflammatory syndrome 1 30.2 SELP RNASE3 IL5 IL4 IL1R1 IL13
38 spondyloarthropathy 1 30.2 IL1R1 ICOSLG CCR6
39 stomatitis 30.2 IL4 IFNA2 CXCL8
40 intrinsic asthma 30.2 RNASE3 IL5 IL4 IL13
41 childhood-onset asthma 30.1 RNASE3 IL13
42 endophthalmitis 30.1 ICAM1 CXCL8 ALB
43 pollen allergy 30.1 RNASE3 IL5 IL13 ICAM1
44 middle ear disease 30.1 IL5 IL4 CXCL8 CCR6 ALB
45 meningoencephalitis 30.1 CCR6 CCL5 ALB
46 autoimmune disease 30.1 IL5 IL4 IL1R1 IL13 ICOSLG CXCL8
47 acute cystitis 30.1 CXCL8 CCR6 ALB
48 diphtheria 30.1 IL5 IL4 IL13 ALB
49 ige responsiveness, atopic 30.1 RNASE3 IL5 IL4 IL13
50 juvenile rheumatoid arthritis 30.1 IL1R1 CXCL8 CCL5 ALB

Graphical network of the top 20 diseases related to Common Cold:



Diseases related to Common Cold
Sources

Symptoms & Phenotypes for Common Cold

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UMLS symptoms related to Common Cold:


fever; pruritus; tinnitus; rhinorrhea; snoring; sore throat; coughing; vertigo/dizziness; equilibration disorder; catarrh

MGI Mouse Phenotypes related to Common Cold:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CCL11 CCL5 CCR6 ICAM1 IL13 IL1R1
2 digestive/alimentary MP:0005381 9.86 ALB ICAM1 IL13 IL1R1 IL33 IL4
3 immune system MP:0005387 9.8 ALB CCL11 CCL5 CCR6 ICAM1 IL13
4 respiratory system MP:0005388 9.28 CCL11 IL13 IL1R1 IL33 IL4 IL5
Sources

Drugs & Therapeutics for Common Cold

About this section

PubMed Health treatment related to Common Cold: 62

Because there are so many different cold viruses , there is currently no medicine that can fight all cold viruses and shorten the length of colds . But various medications can relieve some of the symptoms a little. These include painkillers like ibuprofen and acetaminophen (paracetamol), as well as decongestant (anti-swelling) nasal sprays for temporary use. Antibiotics are usually not effective against colds and, because of their possible side effects, should only be used if there are complications. Products that contain zinc , vitamin C, or echinacea extracts are also commonly recommended for the treatment of colds. It's not currently possible to reliably evaluate the advantages and disadvantages of these herbal products because there has been little research in this area, and the studies that have been done have produced contradictory results. Herbal products like extracts taken from Pelargonium (umckaloabo), primrose, thyme, eucalyptus and ivy may possibly be able to relieve a cough somewhat.

Drugs for Common Cold (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 299)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefditoren Approved, Investigational Phase 4 104145-95-1, 117467-28-4 9571074 9870843
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Azithromycin Approved Phase 4 83905-01-5 55185 447043
5
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Chlorpheniramine Approved Phase 4 113-92-8, 132-22-9 2725
8
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
9
Pseudoephedrine Approved Phase 4 90-82-4 7028
10
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
11
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
12
Phenylephrine Approved Phase 4 59-42-7 6041
13
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
14
Caffeine Approved Phase 4 58-08-2 2519
15
Ethanol Approved Phase 4 64-17-5 702
16
Ipratropium Approved, Experimental Phase 4 22254-24-6, 60205-81-4 43232 657309
17
Thyme Approved Phase 4
18
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
19
Capsaicin Approved Phase 4 404-86-4 1548943
20
Montelukast Approved Phase 4 158966-92-8 5281040
21
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
22
Sodium citrate Approved, Investigational Phase 4 68-04-2
23
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
24
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
25
Acetaminophen Approved Phase 4 103-90-2 1983
26
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
27
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
28
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
29
Salmon calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
30
Erenumab Approved, Investigational Phase 4 1582205-90-0
31
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
32
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
33
Polyestradiol phosphate Approved Phase 4 28014-46-2
34
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
35
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
36
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
37
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
38
Clarithromycin Approved Phase 4 81103-11-9 84029
39
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
40
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
41
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
42 Cefditoren pivoxil Phase 4
43 Anti-Bacterial Agents Phase 4
44 Anti-Infective Agents Phase 4
45 Immunoglobulins Phase 4
46 Antibodies Phase 4
47 Respiratory System Agents Phase 4
48 Adrenergic alpha-Agonists Phase 4
49 Anti-Obesity Agents Phase 4
50 Nasal Decongestants Phase 4

Interventional clinical trials:

(show top 50) (show all 385)
# Name Status NCT ID Phase Drugs
1 A Comparison of Cefditoren Pivoxil 10 mg/kg/Day and Cefditoren Pivoxil 20 mg/kg/Day in Treatment of Childhood With Acute Rhinosinusitis Unknown status NCT01553006 Phase 4 cefditoren pivoxil
2 Clinical Relevance of Middle Meatal Bacteriology During Acute Respiratory Infection in Children - Randomised, Double-Blinded Clinical Study Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
3 Double-blind, Randomized, Placebo-controlled Clinical Study Investigating Efficacy and Safety of Arbidol (Umifenovir) in Treatment and Prophylaxis of Influenza and Common Cold. Unknown status NCT01651663 Phase 4 Arbidol (Umifenovir);Arbidol (Umifenovir)
4 The Evaluation of Singulair for the Treatment of Non-Allergic Rhinitis Eosinophil Syndrome (NARES) Unknown status NCT00406094 Phase 4 montelukast;placebo
5 The Adjunctive Use of a Dexamethasone-Sinufoam Mixture on Endoscopic Sinus Surgery Outcomes: A Randomized, Double-Blind, Placebo-controlled Trial Unknown status NCT01024075 Phase 4 Dexamethasone;Saline
6 Comparison of the Efficacy and Complication of Gentamicin and Normal Saline Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis : a Double Blind Randomized Control Trial Unknown status NCT02582099 Phase 4 Gentamicin nasal irrigation;Normal saline nasal irrigation
7 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
8 Evaluation of Histamine, CGRP and VIP as Biological Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers in Response to "Sinus" Symptoms Completed NCT00208065 Phase 4 almotriptan or pseudoephedrine
9 Randomized, Single Blind, Multicenter Study to Evaluate the Efficacy and Tolerability of Syr. Grintuss Pediatric and Syr. Mucolit in Cough Due to Upper Respiratory Tract Infection in Children Completed NCT01968434 Phase 4 carbocisteine cough syrup
10 Double-blind, Randomized, Placebo-controlled, Single Dose, Parallel Group Study Evaluating Efficacy and Safety of 1000 mg Acetylsalicylic Acid and 1000 mg Paracetamol in Adult Patients With Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
11 Effects of a Common Cold Treatment on Cognitive Function Completed NCT01466348 Phase 4 Paracetamol and Caffeine;Paracetamol
12 A Two-arm, Multicenter, Randomized, Double-blind, Single Dose Placebo-controlled Parallel Groups Study Evaluating Efficacy and Tolerability of 800 mg Acetylsalicylic Acid (Aspirina® C) in Adult Patients With a Common Cold During a Two Hour in Patient Phase; and a Follow-up Period of Five Days of Home Treatment as Required Completed NCT01033526 Phase 4 Aspirin (Acetylsalicylic acid, BAYE4465);Placebo
13 A Double-Blind, Randomised, Placebo-Controlled, Parallelgroup, Single-Dose Study to Evaluate Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza Over a 4 Hour Period Completed NCT02246166 Phase 4 Test tablet
14 Efficacy and Safety of Iota-Carrageenan Nasal Spray 1.2 g/l (0.12 Percent) (Bisolviral) Versus Placebo Nasal Spray in the Early Treatment of Common Cold Completed NCT01944631 Phase 4
15 A Community Pharmacy Based Investigation in the Self-Medication Area Efficacy and Safety of Sinutab and Pseudoephedrine on Subjects With Nasal Congestion Accompanied by Headache in the Setting of a Common Cold Completed NCT00378144 Phase 4 Pseudoephedrine/Paracetamol
16 Randomised Double Blind Placebo Controlled Multicenter Study for Evaluation of Clinical Efficacy and Safety of Ingavirin 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults. Completed NCT03154515 Phase 4 Ingavirin;Placebo
17 A Phase IV Safety Trial in Pediatric Patients (Ages 2-5) With Rhinorrhea Associated With a Common Cold or Allergy Completed NCT02238210 Phase 4 Atrovent®
18 Effectiveness of a Handwashing Programme in the Prevention of School Absenteeism Due to Respiratory Infections Completed NCT01728090 Phase 4
19 A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies Completed NCT01332578 Phase 4 Paracetamol;Phenylephrine;Ascorbic Acid
20 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Completed NCT02288156 Phase 4 Capsaicin;placebo
21 PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute Cough Completed NCT02981147 Phase 4 Phytus (Cisti, Thyme and Ivy Leaves)
22 Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis Completed NCT03705793 Phase 4 Mometasone Furoate Nasal Irrigation;Mometasone Nasal Spray
23 Total Intravenous Versus Inhaled Anesthesia in Endoscopic Sinus Surgery for High-Grade Paranasal Disease Completed NCT02578862 Phase 4 Propofol;Sevoflurane
24 The HVSI STUDY: High Volume Saline Irrigation in the Post-operative Management of Chronic Rhinosinusitis: A Multicenter Randomized Single-Blind Controlled Trial Completed NCT01575223 Phase 4
25 Efficacy and Tolerability of Systemic Methylprednisolone in Children and Adolescents With Chronic Rhinosinusitis Completed NCT01205984 Phase 4 methylprednisolone
26 Azithromycin as add-on Therapy in Patients Failing Medical and Surgical Treatment for Chronic Rhinosinusitis: a Double-blind, Randomized, Placebo-controlled Trial Completed NCT02307825 Phase 4 Azithromycin;Placebo
27 Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis. A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Phase IV Study (Sinusitis Study) Completed NCT02296814 Phase 4 Sinusitis Hevert SL Tablet;Placebo for Sinusitis Hevert SL Tablet
28 The Use of Antibiotic Sinonasal Rinse After Sinus Surgery: A Randomized Double-Blind Control Trial Completed NCT02218307 Phase 4 Mupirocin;Placebo
29 A Randomized Study of Nasal Irrigation Versus Nasal Spray for Chronic Nasal and Sinus Symptoms Completed NCT00318006 Phase 4
30 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in the Non-complicated Acute Respiratory Tract Infections in Pediatric (Study DAP-Pediatrics) Completed NCT01800747 Phase 4
31 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis Completed NCT00396162 Phase 4 probiotic containing L.rhamnosus R0011 strain
32 The Role of Nonspecific Immune Response of the Airway Mucosa in Children With Chronic Rhinosinusitis and Asthma Completed NCT03011632 Phase 4 Mometasone Nasal;placebo mometasone
33 A Randomized Cohort Trial Evaluating Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed NCT01825408 Phase 4 Doxycycline;Azithromycin;Augmentin
34 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery: a 9-month Randomized, Open-label, Controlled Study Completed NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
35 Randomized Clinical Trial to Evaluate Guidelines for Acute Rhinosinusitis (Phase IV Study) Completed NCT00377403 Phase 4 Acetaminophen;Amoxicillin;Dextromethorphan hydrobromide with guaifenesin;Guaifenesin;Pseudoephedrine Sustained Action;Saline spray (0.65%)
36 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis - a Randomized, Double Blind, Placebo Controlled Trial Completed NCT03086070 Phase 4 Omeprazole 20mg;Placebo oral capsule
37 Effect of Celecoxib on Postoperative Narcotic Use and Disease Severity in Patients With Aspirin-exacerbated Respiratory Disease and Chronic Rhinosinusitis: a Randomised Controlled Trial Recruiting NCT04147013 Phase 4 Celecoxib;Placebo
38 A Randomized, Double-Blinded, Single Site Study to Evaluate the Efficacy of Erenumab for Treatment of Idiosyncratic Facial Pain Mimicking Rhinosinusitis Recruiting NCT04249427 Phase 4 Erenumab Prefilled Syringe
39 The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp: A Randomized, Double-blind Clinical Trial Recruiting NCT03809312 Phase 4 Amoxicillin / Clavulanic acid 875mg / 125mg;Placebos
40 Anti-IL4/IL13 Therapy With Dupilumab for Prevention of Refractory Chronic Rhinosinusitis After Endoscopic Sinus Surgery for CRSwNP Not yet recruiting NCT04596189 Phase 4 Dupilumab 300 MG in 2 ML Prefilled Syringe;Mometasone Furoate nasal spray
41 Isotonic vs Hypertonic Nasal Irrigation and Frequency of Irrigation Per Day in Rhinosinusitis Patients Not yet recruiting NCT04213508 Phase 4 Isotonic Saline ( 0.9% Sodium Chloride Saline);Hypertonic Saline ( 3% Sodium Chloride Saline)
42 A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled, Single-Dose, Pilot Study To Evaluate Efficacy Of Dextromethorphan Hydrobromide On Acute Cough In A Pediatric Population Terminated NCT01257542 Phase 4 Dextromethorphan;Placebo
43 Prospective, Multicenter, Randomized, Double Blind, Parallel Arm Study to Evaluate the Efficacy and Safety of Moxifloxacin 400 mg OD for 7 Days Versus a Standard Antibiotic Therapy for 10 Days in the Treatment of Acute Bacterial Rhino Sinusitis Terminated NCT00493038 Phase 4 Moxifloxacin (Avelox, BAY12-8039);Amoxicillin/Clavulanate
44 Canadian Health Economics, Health Outcome, and Effectiveness Comparison of Treatment of the Frontal Sinus Ostium and Recess and Other Sinuses With Functional Endoscopic Sinus Surgery (FESS) or Balloon Sinuplasty in Patients With Chronic Sinusitis (CRS) Terminated NCT01455948 Phase 4
45 Role of Short Term Systemic Corticosteroid Therapy in the Management of Chronic Rhinosinusitis Without Nasal Polyps Terminated NCT01676415 Phase 4 Prednisone;Topical mometasone
46 Bioavailability of an Echinacea Product (Echinaforce® Junior) in Children With a Common Cold, Aged 4-12 Years After Intake of a Daily Dosage Withdrawn NCT03070314 Phase 4 Echinaforce junior
47 Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Withdrawn NCT02119273 Phase 4 Prednisone;Placebo
48 Phase III Clinical Trial - Efficacy and Safety Assessment of a Compound Acetaminophen, Chlorpheniramine and Phenylephrine Combination in the Symptomatic Treatment of Common Cold and Flu-Like Syndrome in Adults Unknown status NCT00940836 Phase 3 Resfenol;Placebo;Co interventional acetaminophen
49 Phase III Study Comparing Coristina® D to Resfenol® in the Symptomatic Treatment of Common Cold Unknown status NCT02735070 Phase 3 Resfenol;Coristina d
50 Influence of Oral Vitamin D3 on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis and Lower Vitamin D Levels Unknown status NCT02668861 Phase 3 Vitamin D;Budesonide Nasal Spray

Search NIH Clinical Center for Common Cold

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ascorbic Acid
Ascorbic Acid Powder
Echinacea Preparation
Guaifenesin
Phenylpropanolamine
Phenylpropanolamine Hydrochloride
Pseudoephedrine
Pseudoephedrine Hydrochloride
Pseudoephedrine sulfate
Sodium Ascorbate
Zinc Acetate
zinc chloride
Zinc Gluconate
Zinc Sulfate
ZINC SULFATE PWDR

Cochrane evidence based reviews: common cold

Sources

Genetic Tests for Common Cold

About this section
Sources

Anatomical Context for Common Cold

About this section

MalaCards organs/tissues related to Common Cold:

40
Skin, Pituitary, Bone, Heart, Lung, Neutrophil, Thyroid
Sources

Publications for Common Cold

About this section

Articles related to Common Cold:

(show top 50) (show all 3840)
# Title Authors PMID Year
1
Distinct antibody repertoires against endemic human coronaviruses in children and adults. 42 61
33497357 2021
2
Comparison of the clinical differences between COVID-19, SARS, influenza, and the common cold: A systematic literature review. 42 61
33529514 2021
3
Interactions between seasonal human coronaviruses and implications for the SARS-CoV-2 pandemic: A retrospective study in Stockholm, Sweden, 2009-2020. 42
33601153 2021
4
Cigarette smoke extract enhances rhinovirus-induced toll-like receptor 3 expression and interleukin-8 secretion in A549 cells. 61 54
19769802 2009
5
Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus a21. 61 54
14734451 2004
6
The common cold at the turn of the millennium. 54 61
11068660 2000
7
Experimental rhinovirus 16 infection increases intercellular adhesion molecule-1 expression in bronchial epithelium of asthmatics regardless of inhaled steroid treatment. 61 54
10848925 2000
8
Experimental common cold increases mucosal output of eotaxin in atopic individuals. 54 61
10604558 1999
9
Allergen challenge-induced acute exudation of IL-8, ECP and alpha2-macroglobulin in human rhinovirus-induced common colds. 54 61
10836321 1999
10
Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. 61 54
9564459 1998
11
Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma. 61 54
9105080 1997
12
Elevated levels of interleukins IL-1 beta, IL-6 and IL-8 in naturally acquired viral rhinitis. 61 54
7734976 1995
13
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic. 61
33666147 2021
14
Novel dual multiplex real-time RT-PCR assays for the rapid detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the BD MAX open system. 61
33410371 2021
15
Mental associations with COVID-19 and how they relate with self-reported protective behaviors: A national survey in the United States. 61
33735777 2021
16
Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection. 61
33357024 2021
17
The burden of the pandemic on the non-SARS-CoV-2 emergencies: A multicenter study. 61
33429189 2021
18
The Cost of Coronavirus Obligations: Respecting the Letter and Spirit of Lockdown Regulations. 61
33004099 2021
19
Lactoferrin affects rhinovirus B-14 entry into H1-HeLa cells. 61
33606112 2021
20
Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the "Dr. Juan I. Menchaca" Civil Hospital of Guadalajara (Jalisco, Mexico). 61
33118203 2021
21
Impact of a Social Marketing Intervention on General Practitioners' Antibiotic Prescribing Practices for Acute Respiratory Tract Complaints in Malta. 61
33807404 2021
22
No SARS-CoV-2 carriage observed in children attending daycare centers during the intial weeks of the epidemic in Belgium. 61
33230857 2021
23
Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold- An ARIA-EAACI-GA2 LENconsensus. 61
33730365 2021
24
The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. 61
33757938 2021
25
High levels of common cold coronavirus antibodies in convalescent plasma are associated with improved survival in COVID-19 patients. 61
33758890 2021
26
Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19. 61
33772626 2021
27
Chemosensory dysfunction in COVID-19 out-patients. 61
32844305 2021
28
Human rhinovirus infection blocks SARS-CoV-2 replication within the respiratory epithelium: implications for COVID-19 epidemiology. 61
33754149 2021
29
An evaluation of patients with a previous endemic coronavirus infection during the COVID-19 pandemic. 61
33724483 2021
30
Review a brief history of coronaviruses in Thailand. 61
33285189 2021
31
An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity. 61
33810391 2021
32
Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs. 61
33758849 2021
33
Prevalence of respiratory tract infections and influencing factors: A cross-sectional survey in Anhui Province, China. 61
33655587 2021
34
Inactivation of SARS-CoV-2 and HCoV-229E in vitro by ColdZyme® a medical device mouth spray against the common cold. 61
32975843 2021
35
Verified infections with endemic common cold coronaviruses do not entail significant protection against SARS-CoV-2. 61
33780548 2021
36
Traditional medicine for the treatment of common cold in Korean adults: A nationwide population-based study. 61
32913704 2021
37
A pilot study of cadre training to promote responsible self-medication in Indonesia: Which is better specific or general modules? 61
32783277 2021
38
Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters. 61
33730506 2021
39
Limited specificity of commercially available SARS-CoV-2 IgG ELISAs in serum samples of African origin. 61
33666297 2021
40
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system. 61
33444702 2021
41
Association between exposure during pregnancy and the risk of developing solid tumors in second children: Results from a Chinese matched case-control study. 61
33517172 2021
42
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors. 61
33713730 2021
43
Systematic review of the alkaloid constituents in several important medicinal plants of the Genus Corydalis. 61
33429352 2021
44
Ensemble Analysis Identifies Nasal 15-Keto-PGE2 as a Predictor of Recovery in Experimental Rhinovirus Colds. 61
33681993 2021
45
Road toward universal COVID-19 testing method - A review. 61
33689569 2021
46
Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques Following SARS-CoV-2 Vaccination and Infection. 61
33692201 2021
47
More than just a common cold: Endemic coronaviruses OC43, HKU1, NL63, and 229E associated with severe acute respiratory infection and fatality cases among healthy adults. 61
32720706 2021
48
Animal Coronaviruses and SARS-COV-2 in Animals, What Do We Actually Know? 61
33562645 2021
49
Upper Respiratory Infections in Schools and Childcare Centers Reopening after COVID-19 Dismissals, Hong Kong. 61
33596168 2021
50
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals. 61
33728095 2021
Sources

Variations for Common Cold

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Expression for Common Cold

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Search GEO for disease gene expression data for Common Cold.
Sources

Pathways for Common Cold

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Pathways related to Common Cold according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.95 RNASE3 IL5 IL4 IL33 IL1R1 IL13
2
PEDF Induced Signaling 63
Show member pathways
 13.61 TSLP IL5 IL4 IL33 IL1R1 IL13
3
TGF-Beta Pathway 63
Show member pathways
 13.5 IL5 IL4 IL1R1 IL13 IFNA2 ICAM1
4
Akt Signaling 63
Show member pathways
 13.37 IL5 IL4 IL1R1 IL13 CXCL8 CCR6
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.27 IL5 IL4 IL33 IL1R1 IL13 IFNA2
6
PAK Pathway 63
Show member pathways
 13.25 IL5 IL4 IL1R1 IL13 CXCL8 CCR6
7
Pathways in cancer 36
12.79 IL5 IL4 IL13 IFNA2 CXCL8
8
Measles 36
Show member pathways
 12.77 IL33 IFNA2 ICAM1 CXCL8 CCL5
9
Allograft rejection 36 1
Show member pathways
 12.72 RNASE3 IL5 IL4 IL13 IFNA2 ICOSLG
10
JAK-STAT signaling pathway 36
Show member pathways
 12.36 TSLP IL5 IL4 IL13 IFNA2
11
Immune response CCR3 signaling in eosinophils 23
Show member pathways
 12.29 ICAM1 CXCL8 CCL5 CCL11
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.29 IL5 IL4 IL13 CXCL8 CCL11
13
Selenium Micronutrient Network 1
Show member pathways
 12.28 IL4 ICAM1 CCL5 ALB
14
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.28 CXCL8 CCR6 CCL5 CCL11
15
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.23 IL5 IL4 IL13 IFNA2 CXCL8
16
Bacterial infections in CF airways 23
Show member pathways
 12.15 IL4 IL1R1 CXCL8 CCL11
17
Spinal Cord Injury 1
11.97 SELP IL4 IL1R1 ICAM1 CXCL8
18
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.96 PTGDR2 IL5 IL4 IFNA2
19
Interleukin-4 and 13 signaling 65
11.93 IL4 IL13 ICAM1 CXCL8 CCL11
20
Rheumatoid arthritis 36
11.81 ICAM1 CXCL8 CCL5
21
Glucocorticoid receptor regulatory network 1
11.74 IL5 IL4 IL13 ICAM1 CXCL8
22
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.71 IL5 IL4 CXCL8
23
IL4-mediated signaling events 1
11.64 SELP IL5 IL4 CCL11
24
IgA-Producing B Cells in the Intestine 64
11.62 IL5 IL4 ICOSLG ICAM1 CCR6
25
Malaria 36
11.51 SELP ICAM1 CXCL8
26
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.48 TSLP CXCL8 CCL11
27
Th2 Differentiation Pathway 64
11.43 IL5 IL4 IL33 IL13 CCL11
28
Lung fibrosis 1
11.43 IL5 IL4 IL13 CXCL8 CCL5 CCL11
29
Cytokines and Inflammatory Response 1
11.23 IL5 IL4 IL13
30
OX40 Pathway 63
11.17 IL5 IL4 IL13
31
Development and heterogeneity of the ILC family 1
11.16 TSLP IL5 IL4 IL33 IL13
32
Innate Lymphoid Cell Differentiation Pathways 64
11.13 TSLP PTGDR2 IL5 IL4 IL33 IL1R1
33
Interleukin-10 signaling 65
11.12 IL4 IL1R1 IL13 ICAM1 CXCL8 CCL5
34
G-protein signaling_Rap2B regulation pathway 23
10.99 IL5 IL4 IL13 CXCL8 CCL5 CCL11
35
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.77 IL5 IL4 IL13
Sources

GO Terms for Common Cold

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Cellular components related to Common Cold according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TSLP RNASE3 LPO IL5 IL4 IL33
2 external side of plasma membrane GO:0009897 9.63 SELP IL1R1 IL13 ICOSLG ICAM1 CCR6
3 extracellular space GO:0005615 9.5 VLDLR TSLP SELP RNASE3 LPO IL5

Biological processes related to Common Cold according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.15 VLDLR TSLP TAS2R38 PTGDR2 IL5 IL4
2 cellular response to tumor necrosis factor GO:0071356 9.86 ICAM1 CXCL8 CCL5 CCL11
3 defense response to Gram-negative bacterium GO:0050829 9.79 TSLP SELP RNASE3
4 calcium-mediated signaling GO:0019722 9.79 PTGDR2 CXCL8 CCR6
5 neutrophil chemotaxis GO:0030593 9.77 CXCL8 CCL5 CCL11
6 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.76 TSLP RNASE3 CXCL8
7 cellular response to interleukin-1 GO:0071347 9.76 ICAM1 CXCL8 CCL5 CCL11
8 inflammatory response GO:0006954 9.76 SELP IL5 IL1R1 IL13 IFNA2 CXCL8
9 positive regulation of B cell proliferation GO:0030890 9.74 IL5 IL4 IL13
10 chemokine-mediated signaling pathway GO:0070098 9.73 CXCL8 CCR6 CCL5 CCL11
11 chemotaxis GO:0006935 9.73 RNASE3 PTGDR2 CXCL8 CCR6 CCL5 CCL11
12 positive regulation of interleukin-10 production GO:0032733 9.72 TSLP IL4 IL13
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 TSLP IL4 IL13 IFNA2 CCL5
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.71 IL4 IL13 ICAM1
15 leukocyte cell-cell adhesion GO:0007159 9.67 SELP ICAM1 CCL5
16 positive regulation of immunoglobulin production GO:0002639 9.65 IL5 IL33 IL13
17 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.63 CXCL8 CCL5
18 neutrophil activation GO:0042119 9.63 CXCL8 CCL5
19 macrophage activation GO:0042116 9.62 IL4 IL13
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IL4 IL33
21 immune response GO:0006955 9.61 PTGDR2 IL5 IL4 IL1R1 IL13 CXCL8
22 positive regulation of interleukin-5 production GO:0032754 9.59 TSLP IL33
23 positive regulation of mast cell degranulation GO:0043306 9.58 IL4 IL13
24 positive regulation of interleukin-13 production GO:0032736 9.58 TSLP IL4 IL33
25 negative regulation of complement-dependent cytotoxicity GO:1903660 9.52 IL4 IL13
26 positive regulation of cellular biosynthetic process GO:0031328 9.51 CXCL8 CCL5
27 cytokine-mediated signaling pathway GO:0019221 9.28 IL5 IL4 IL1R1 IL13 IFNA2 ICAM1

Molecular functions related to Common Cold according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CXCL8 CCL5 CCL11
2 cytokine activity GO:0005125 9.28 TSLP IL5 IL4 IL33 IL13 IFNA2
3 cytokine receptor binding GO:0005126 9.13 IL4 IL13 IFNA2