Common Cold disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CMM005 MIFTS: 62	Common Cold Categories: Infectious diseases, Oral diseases, Respiratory diseases, Smell/Taste diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Common Cold

MalaCards integrated aliases for Common Cold:

Name: Common Cold ¹² ⁷⁷ ⁵⁶ ⁴⁴ ³ ⁴⁵ ¹⁵ ¹⁷ ⁷⁴

Acute Viral Rhinopharyngitis ¹²

Nasopharyngitis - Acute ¹²

Nasopharyngitis, Acute ¹²

Acute Nasopharyngitis ¹²

Rhino-Sinusitis ¹²

Acute Rhinitis ¹²

Rhinosinusitis ¹⁵

Acute Coryza ¹²

Common Colds ⁶⁴

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Smell/Taste diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the respiratory system

Acute upper respiratory infections

Acute nasopharyngitis [common cold]

External Ids:

Disease Ontology ¹² DOID:10459

ICD9CM ³⁶ 460

MeSH ⁴⁵ D003139

NCIt ⁵¹ C34500 C78599

SNOMED-CT ⁶⁹ 54150009 82272006

ICD10 ³⁴ J00

EFO ¹⁷ EFO_0007214

UMLS ⁷⁴ C0009443

Sources

Summaries for Common Cold

MedlinePlus : ⁴⁴ Sneezing, sore throat, a stuffy nose, coughing - everyone knows the symptoms of the common cold. It is probably the most common illness. In the course of a year, people in the United States suffer 1 billion colds. You can get a cold by touching your eyes or nose after you touch surfaces with cold germs on them. You can also inhale the germs. Symptoms usually begin 2 or 3 days after infection and last 2 to 14 days. Washing your hands and staying away from people with colds will help you avoid colds. There is no cure for the common cold. But there are treatments that can make you feel better while you wait for the cold to go away on its own: Getting plenty of rest Drinking fluids Gargling with warm salt water Using cough drops or throat sprays Taking over-the-counter pain or cold medicines However, do not give aspirin to children. And do not give cough medicine to children under four.

MalaCards based summary : Common Cold, also known as acute viral rhinopharyngitis, is related to pulmonary disease, chronic obstructive and viral infectious disease, and has symptoms including fever, pruritus and tinnitus. An important gene associated with Common Cold is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Montelukast and Capsaicin have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and testes, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : ¹² An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

CDC : ³ Sore throat and runny nose are usually the first signs of a cold, followed by coughing and sneezing. Most people recover in about 7-10 days. You can help reduce your risk of getting a cold: wash your hands often, avoid close contact with sick people, and don’t touch your face with unwashed hands.

PubMed Health : ⁶⁴ About common colds: Common colds, or simply “colds,” are usually quite harmless and go away again on their own. Symptoms of a cold such as a cough, sore throat and a runny nose can be really annoying. A severe cold can make you feel weak and ill, too.Colds usually go away on their own after about a week, but some symptoms may last longer. Although a sore throat or a stuffy nose may be gone after just a few days, it can sometimes take up to three weeks for a cough to disappear completely.Treatment with medication usually isn’t necessary. Some medications may, at best, help relieve the symptoms a bit. Because colds are typically caused by viruses, it also doesn't make sense to use antibiotics to treat an ordinary cold. Antibiotics only work against bacteria.

Wikipedia : ⁷⁷ The common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory... more...

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Related Diseases for Common Cold

Diseases related to Common Cold via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)

#	Related Disease	Score	Top Affiliating Genes
1	pulmonary disease, chronic obstructive	32.2	CCL11 CCL5 CXCL8 IL13 RNASE3
2	viral infectious disease	31.3	CCL5 CXCL8 IFNA2
3	sinusitis	30.5	CXCL8 IL5 RNASE3
4	ige responsiveness, atopic	30.4	IL13 IL5 RNASE3
5	cytokine deficiency	30.3	IL13 IL5
6	cellulitis	30.3	IL1R1 IL5 RNASE3
7	otitis media	30.1	ALB CCL11 CXCL8 RNASE3
8	pyoderma	30.0	CXCL8 IFNA2 IL1R1
9	maxillary sinusitis	29.9	CCL5 RNASE3 SELP
10	bronchitis	29.9	ALB CCL11 CXCL8 IL5 RNASE3
11	rhinitis	29.5	CCL11 CCL5 CXCL8 ICAM1 IL13 IL5
12	allergic rhinitis	29.5	CCL11 CXCL8 ICAM1 IL13 IL5 RNASE3
13	dermatitis	29.4	CCL11 IL13 IL5 TSLP
14	food allergy	29.4	ALB IL13 IL5 RNASE3
15	allergic hypersensitivity disease	29.4	CCL11 CCL5 IL13 IL5 RNASE3 TSLP
16	hypereosinophilic syndrome	29.3	CCL11 IL13 IL5 RNASE3
17	pneumonia	29.3	CCL11 CCL5 CXCL8 IL13 IL5
18	allergic asthma	29.2	CCL11 CCL5 IL13 IL5 RNASE3 TSLP
19	esophagitis, eosinophilic, 1	29.2	CCL11 IL13 IL5 TSLP
20	myocardial infarction	29.0	ALB CCL5 ICAM1 LDLR POSTN SELP
21	bronchiolitis	29.0	CCL11 CCL5 CXCL8 IL13 IL5 RNASE3
22	esophagitis	28.9	CCL11 CXCL8 IL13 IL5 TSLP
23	dermatitis, atopic	28.5	CCL11 CCL5 CXCL8 ICAM1 IL13 IL5
24	asthma	28.4	CCL11 CCL5 CXCL8 ICAM1 IL13 IL1R1
25	malaria	27.9	ALB CCL11 CCL5 CXCL8 ICAM1 IL13
26	nasopharyngitis	11.5
27	influenza	11.3
28	otosalpingitis	11.2
29	young syndrome	11.1
30	ciliary dyskinesia, primary, 22	11.1
31	tonsillitis	10.9
32	pertussis	10.9
33	mda5 deficiency	10.9
34	papillary conjunctivitis	10.4	CCL11 CXCL8
35	chloramine t respiratory allergy	10.4	ALB RNASE3
36	heterophyiasis	10.4	ALB ICAM1
37	bone inflammation disease	10.4
38	pemphigoid gestationis	10.3	CCL11 IL5
39	st. louis encephalitis	10.3	IFNA2 RNASE3
40	vulvovaginitis	10.3	CCL11 CCL5 CXCL8
41	toxicodendron dermatitis	10.3	CXCL8 ICAM1
42	pyuria	10.3	ALB CXCL8
43	scabies	10.3	CCL11 CXCL8
44	herpes simplex virus keratitis	10.3	CXCL8 ICAM1
45	blepharoconjunctivitis	10.3	CCL11 RNASE3
46	bagassosis	10.3	CXCL8 IL5
47	spastic paraplegia, intellectual disability, nystagmus, and obesity	10.3
48	extrinsic allergic alveolitis	10.3	ALB CCL5 CXCL8
49	loeffler endocarditis	10.3	IL5 RNASE3
50	folliculitis	10.3	CCL11 CCL5 IL5

Graphical network of the top 20 diseases related to Common Cold:

Sources

Symptoms & Phenotypes for Common Cold

UMLS symptoms related to Common Cold:

fever, pruritus, tinnitus, snoring, rhinorrhea, sore throat, coughing, vertigo/dizziness, equilibration disorder, catarrh

MGI Mouse Phenotypes related to Common Cold:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.9	CCL11 CCL5 ICAM1 IL13 IL1R1 IL33
2	digestive/alimentary	MP:0005381	9.8	ALB ICAM1 IL13 IL33 IL5 LDLR
3	immune system	MP:0005387	9.7	CCL11 CCL5 ICAM1 IL13 IL1R1 IL33
4	respiratory system	MP:0005388	9.17	CCL11 IL13 IL1R1 IL33 IL5 SELP

Sources

Drugs & Therapeutics for Common Cold

PubMedHealth treatment related to Common Cold: ⁶⁴

Because there are so many different cold viruses, there is currently no medicine that can fight all cold viruses and shorten the length of colds. But various medications can relieve some of the symptoms a little. These include painkillers like ibuprofen and acetaminophen (paracetamol), as well as decongestant (anti-swelling) nasal sprays for temporary use.Antibiotics are usually not effective against colds and, because of their possible side effects, should only be used if there are complications. Products that contain zinc, vitamin C, or echinacea extracts are also commonly recommended for the treatment of colds. It's not currently possible to reliably evaluate the advantages and disadvantages of these herbal products because there has been little research in this area, and the studies that have been done have produced contradictory results. Herbal products like extracts taken from Pelargonium (umckaloabo), primrose, thyme, eucalyptus and ivy may possibly be able to relieve a cough somewhat.

Drugs for Common Cold (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 269)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Montelukast

Approved

Phase 4,Phase 3,Not Applicable

158966-92-8

5281040

Capsaicin

Approved

Phase 4,Phase 2

404-86-4

1548943

Ethanol

Approved

Phase 4,Not Applicable

64-17-5

702

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Caffeine

Approved

Phase 4,Phase 3

58-08-2

2519

Acetaminophen

Approved

Phase 4,Phase 3,Phase 2,Phase 1

103-90-2

1983

Aspirin

Approved, Vet_approved

Phase 4,Phase 3

50-78-2

2244

Histamine

Approved, Investigational

Phase 4,Phase 3,Phase 1,Not Applicable

51-45-6

774

Ephedrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

299-42-3

9294

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

93-14-1

3516

Pseudoephedrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

90-82-4

7028

Oxymetazoline

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

1491-59-4

4636

Phenylephrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

59-42-7

6041

Ipratropium

Approved, Experimental

Phase 4

22254-24-6, 60205-81-4

657309 43232

Dextromethorphan

Approved

Phase 4,Phase 3,Phase 1

125-71-3

5362449 5360696

Thyme

Approved

Phase 4,Not Applicable

Chlorhexidine

Approved, Vet_approved

Phase 4,Phase 3

55-56-1

2713 9552079

Echinacea

Approved, Experimental

Phase 4,Phase 3,Phase 2,Not Applicable

Oseltamivir

Approved

Phase 4

204255-11-8, 196618-13-0

65028

Azelastine

Approved

Phase 4,Phase 3

58581-89-8

2267

Orange

Approved

Phase 4,Not Applicable

Fluticasone

Approved, Experimental

Phase 4

90566-53-3

62924

Vitamin C

Approved, Nutraceutical

Phase 4,Phase 3,Not Applicable

50-81-7

54670067 5785

Glycine

Approved, Nutraceutical, Vet_approved

Phase 4

56-40-6

750

Andrographolide

Investigational

Phase 4,Not Applicable

5508-58-7

Maleic acid

Experimental, Investigational

Phase 4,Phase 3

110-17-8, 110-16-7

444972

BCG vaccine

Investigational

Phase 4

Hormones

Phase 4,Phase 3,Phase 2,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Not Applicable

Leukotriene Antagonists

Phase 4,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Not Applicable

Respiratory System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Dermatologic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Antipruritics

Phase 4,Phase 3,Phase 2,Phase 1

Sodium Benzoate

Phase 4

Antifungal Agents

Phase 4

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3

Platelet Aggregation Inhibitors

Phase 4,Phase 3

Analgesics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Not Applicable

Andrographis

Phase 4,Not Applicable

Antiparasitic Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4,Phase 3

Antiprotozoal Agents

Phase 4

Analgesics, Non-Narcotic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antipyretics

Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 236)

#	Name	Status	NCT ID	Phase	Drugs
1	A Study of Arbidol (Umifenovir) for Treatment and Prophylaxis of Influenza and Common Cold	Unknown status	NCT01651663	Phase 4	Arbidol (Umifenovir);Arbidol (Umifenovir)
2	Singulair Use in Non-Allergic Rhinitis Eosinophil Syndrome (NARES)	Unknown status	NCT00406094	Phase 4	montelukast;placebo
3	Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis	Unknown status	NCT02288156	Phase 4	Capsaicin;placebo
4	Bromelin, a Compound Prepared With Ananas Comocus Extract and Honey, for Acute Cough	Unknown status	NCT01356693	Phase 4	Bromelin;Placebo
5	Montelukast for Persistent Cough in Young People and Adults	Unknown status	NCT01279668	Phase 4	Montelukast;Placebo
6	A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis	Unknown status	NCT03132610	Phase 4	andrographolide sulfonate;andrographolide sulfonate simulation
7	Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis	Unknown status	NCT03134443	Phase 4	Andrographolide sulfonate;Andrographolide sulfonate simulation
8	Effects of a Common Cold Treatment on Cognitive Function	Completed	NCT01466348	Phase 4	Paracetamol and Caffeine;Paracetamol
9	Symptomatic Treatment of Common Cold Symptoms	Completed	NCT01033526	Phase 4	Aspirin (Acetylsalicylic acid, BAYE4465);Placebo
10	Iota-Carrageenan Nasal Spray in Common Cold	Completed	NCT01944631	Phase 4
11	Safety Trial of Atrovent® in Pediatric Patients With Rhinorrhea Associated With a Common Cold or Allergy	Completed	NCT02238210	Phase 4	Atrovent®
12	The Effect of Paracetamol, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Tablets Compared to Placebo in Subjects Suffering From the Common Cold or Influenza.	Completed	NCT02246166	Phase 4	Test tablet
13	Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold	Completed	NCT01465009	Phase 4	Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
14	Efficacy and Safety of Sinutab on Subjects in the Setting of a Common Cold	Completed	NCT00378144	Phase 4	Pseudoephedrine/Paracetamol
15	PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute Cough	Completed	NCT02981147	Phase 4	Phytus (Cisti, Thyme and Ivy Leaves)
16	A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies	Completed	NCT01332578	Phase 4	Paracetamol;Phenylephrine;Ascorbic Acid
17	Effectiveness of Oxymetazoline Added on Nasal Steroid in Rhinitis With Persistent Nasal Obstruction	Completed	NCT01847131	Phase 4	oxymetazoline;Placebo nasal spray
18	Effectiveness of a Handwashing Programme in the Prevention of School Absenteeism Due to Respiratory Infections	Completed	NCT01728090	Phase 4
19	Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children.	Completed	NCT01968434	Phase 4	carbocisteine cough syrup
20	Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults	Completed	NCT03154515	Phase 4	Ingavirin;Placebo
21	Evaluate the Potential of Montelukast to Prevent Nasal Symptomatology During Colds	Completed	NCT00189475	Phase 4	Montelukast
22	Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold	Completed	NCT02807220	Phase 4	Imuneks 10mg
23	Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children.	Completed	NCT01694108	Phase 4
24	Echinacea Safety Study	Completed	NCT01021995	Phase 4	echinacea;placebo
25	Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis	Completed	NCT00000411	Phase 4
26	Prevention of RSV Infections in Bone Marrow Transplant Recipients	Completed	NCT00001903	Phase 4	RSV Polyclonal Immunoglobulin
27	A Study of Oseltamivir (Tamiflu) for the Seasonal Prophylaxis of Influenza in Immunocompromised Participants	Completed	NCT00412737	Phase 4	Oseltamivir;Placebo
28	Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis	Completed	NCT00979615	Phase 4	Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
29	Effect of OM-85 BV on Wheezing Related Morbidity in Children With Recurrent Wheezing	Completed	NCT00733226	Phase 4	OM-85 BV (Broncho-Vaxom);OM-85 BV (placebo)
30	Dextromethorphan Pediatric Acute Cough Study	Recruiting	NCT02651116	Phase 4	Dextromethorphan Hydrobromide;Placebo
31	Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea	Recruiting	NCT02630121	Phase 4	Oxymetazoline Hydrochloride;Placebo
32	Immune Response to High-Dose vs. Standard Dose Influenza Vaccine	Active, not recruiting	NCT02297542	Phase 4
33	Non-specific Effects of Rabies Vaccine	Enrolling by invitation	NCT03656198	Phase 4	Sterile Water Injection
34	Acute Cough Study In Children	Terminated	NCT01257542	Phase 4	Dextromethorphan;Placebo
35	Study Of RV-39 In Patients Who Also Have Asthma	Terminated	NCT00503009	Phase 4	fluticasone propionate/salmeterol;fluticasone propionate;placebo
36	Echinaforce Junior Bioavailability Trial	Withdrawn	NCT03070314	Phase 4	Echinaforce junior
37	Study Comparing Coristina® D to Resfenol® in the Symptomatic Treatment of Common Cold	Unknown status	NCT02735070	Phase 3	Resfenol;Coristina d
38	Efficacy and Safety Assessment of an Anti-Cold Preparation in the Symptomatic Treatment of Common Cold and Flu-Like Syndrome	Unknown status	NCT00940836	Phase 3	Resfenol;Placebo;Co interventional acetaminophen
39	Effectiveness and Safety of the of Guaifenesin, Doxylamine Succinate and Hydrochloride Etafedrine Syrup in Improvement of Symptoms Resulting From Acute Respiratory Infections.	Unknown status	NCT00857987	Phase 3	EMS Expectorant
40	Mepolizumab Treatment for Rhinovirus-induced Asthma Exacerbations	Unknown status	NCT01520051	Phase 3	Mepolizumab;Placebo
41	Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants	Unknown status	NCT01249911	Phase 3
42	Effects of Two Doses of a Common Cold Treatment on Alertness	Completed	NCT01686646	Phase 3	paracetamol + caffeine;paracetamol
43	Decongestant Effect, Timing of Effect and Impact on Sleep and General Well-Being of Xylometazoline in Subjects With a Common Cold	Completed	NCT00452270	Phase 3	Xylometazoline
44	Evaluation of Efficacy and Safety of Oral Solution Resfenol in Reducing Symptoms of Common Cold And Flu	Completed	NCT01158326	Phase 3	Resfenol
45	A Multicenter Study of Pseudoephedrine for the Temporary Relief of Nasal Congestion in Children With the Common Cold	Completed	NCT01744106	Phase 3	pseudoephedrine hydrochloride 30 mg tablets;Placebo tablets
46	Echinacea Versus Placebo Effect in Common Cold (Physician Echinacea Placebo)	Completed	NCT00065715	Phase 3
47	Pomegranate Products for Prevention of Common Cold	Completed	NCT00617318	Phase 3
48	Efficacy and Safety of Paracetamol, Chlorpheniramine and Phenylephrine in the Treatment of Common Cold and Flu Syndrome	Completed	NCT01389518	Phase 3	Active;Placebo
49	Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold	Completed	NCT01361399	Phase 3	Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo
50	Safety and Intake Effect of EPs® 7630 (an Extract of the Roots of Pelargonium Sidoides)	Completed	NCT02174653	Phase 3	EPs® 7630;Placebo

Search NIH Clinical Center for Common Cold

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

ascorbic acid

ascorbic acid powder

echinacea preparation

guaifenesin

phenylpropanolamine

phenylpropanolamine hydrochloride

pseudoephedrine

pseudoephedrine hydrochloride

pseudoephedrine sulfate

sodium ascorbate

zinc acetate

zinc chloride

zinc gluconate

zinc sulfate

zinc sulfate pwdr

Cochrane evidence based reviews: common cold

Sources

Genetic Tests for Common Cold

Sources

Anatomical Context for Common Cold

MalaCards organs/tissues related to Common Cold:

⁴²

Eye, Bone, Testes, Breast, Lung, Bone Marrow, Tonsil

Sources

Publications for Common Cold

Articles related to Common Cold:

(show top 50) (show all 1163)

#	Title	Authors	Year
1	Short-course administration of a traditional herbal mixture ameliorates asthma symptoms of the common cold in children. ( 30984577 )	Javid A...Ahanchian H	2019
2	The use of a poster to reduce expectations to receive antibiotics for a common cold. ( 31102079 )	Ritchie SR...Sajtos L	2019
3	Non-interventional observational study broadens positive benefit-risk assessment of an immunomodulating herbal remedy in the common cold. ( 31074674 )	Henneicke-von Zepelin HH...Nolte KU	2019
4	Assessment of patient counselling on the common cold treatment at Slovak community pharmacies using mystery shopping. ( 31061627 )	Min?rikov? D...Juri?ov? E	2019
5	Not just the common cold: Rhinovirus infection in lung allograft recipients. ( 31004394 )	Singanayagam A...Johnston SL	2019
6	Safety and Efficacy of 0.5% Carbomer 980 Gel for Treatment of Symptoms of Common Cold: Results of 2 Randomized Trials. ( 31004286 )	Dennie L	2019
7	Tackling the outcome bias related to the effectiveness of antibiotics against the common cold: results of a randomized controlled trial applying the Solomon four-group design. ( 30926995 )	Ludolph R...Schulz PJ	2019
8	Binafuxi granules in the treatment of common cold with heat syndrome based on traditional Uighur medicine: study protocol for a multicenter randomized controlled trial. ( 30922355 )	Min J...Chen Y	2019
9	Antibiotic prescription for under-fives with common cold or upper respiratory tract infection in Savannakhet Province, Lao PDR. ( 30858755 )	Keohavong B...Hamajima N	2019
10	The Common Cold. ( 30829428 )		2019
11	A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold. ( 30705369 )	Ramalingam S...Sheikh A	2019
12	A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka. ( 29444701 )	Jayaweera JAAS...Rayes MLM	2018
13	Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens. ( 29111214 )	Bashir H...Gern JE	2018
14	Efficacy and Tolerability of High-dose Pelargonium Extract in Patients With the Common Cold. ( 29055287 )	Riley DS...Lehmacher W	2018
15	Effects of common cold and concomitant administration of nasal decongestant on the pharmacokinetics and pharmacodynamics of nasal glucagon in otherwise healthy participants: A randomized clinical trial. ( 29053231 )	Guzman CB...Sicard E	2018
16	Healthier without healthcare? The paradox of the common cold. ( 30587182 )	de Luca D...Schildgen O	2018
17	Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in COPD: More than a Common Cold. ( 30571921 )	Sabroe I...Dockrell DH	2018
18	"With fever it's the real flu I would say": laypersons' perception of common cold and influenza and their differences - a qualitative study in Austria, Belgium and Croatia. ( 30541479 )	Mayrhuber EA...Hoffmann K	2018
19	Soshiho-tang for treating common cold in children younger than 12 years: A systematic review and meta-analysis of randomized controlled trials. ( 30407301 )	Jung J...Lee JA	2018
20	What are the effects of vitamin C on the duration and severity of the common cold? ( 30339136 )	Quidel S...Ortigoza ?	2018
21	What treatments are effective for common cold in adults and children? ( 30305295 )	van Driel ML...De Sutter A	2018
22	Effects of orally administered lactoferrin and lactoperoxidase on symptoms of the common cold. ( 30202407 )	Shin K...Kurokawa M	2018
23	Does vitamin C prevent the common cold? ( 30113569 )	G?mez E...Ortigoza ?	2018
24	Eunkyosan for treatment of the common cold: A protocol for the systematic review of controlled trials: Erratum. ( 30113505 )		2018
25	Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults. ( 30099891 )	Murata M...Miura K	2018
26	Antibiotic use in the management of children with the common cold at a provincial hospital in Papua New Guinea: a point-prevalence study. ( 30079842 )	Zamunu A...Duke T	2018
27	Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling. ( 30076382 )	Chen X...Obukhov AG	2018
28	Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials. ( 30069463 )	Ran L...Bu H	2018
29	Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies. ( 30037024 )	Furushima D...Yamada H	2018
30	A potential cure for the common cold. ( 29789723 )		2018
31	Potential common factors associated with predisposition to common cold in middle-aged and elderly Japanese: A community-based cross-sectional study. ( 29768343 )	Shibata M...Nakajima K	2018
32	Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. ( 29760414 )	Mousnier A...Tate EW	2018
33	Eunkyosan for treatment of the common cold: A protocol for the systematic review of controlled trials. ( 29718842 )	Lee H...Lee JA	2018
34	Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study. ( 29593018 )	Hei SV...Fingleton J	2018
35	Acupuncture for common cold: A systematic review and meta-analyze protocol. ( 29517665 )	Cheng Y...Guo T	2018
36	Smoking, leisure-time exercise and frequency of self-reported common cold among the general population in northeastern China: a cross-sectional study. ( 29486739 )	Zhou G...Zhang X	2018
37	Prenatal exposure to ambient temperature variation increases the risk of common cold in children. ( 29476971 )	Lu C...Deng Q	2018
38	Diagnostic delay for imported malaria: A case of Plasmodium falciparum malaria misdiagnosed as common cold. ( 29340263 )	Hase R	2018
39	Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population. ( 29301349 )	Rafiq R...den Heijer M	2018
40	Efficacy and safety of Reduqing granules in the treatment of common cold with wind-heat syndrome: a randomized, double-blind, double-dummy, positive-controlled trial. ( 29960290 )	Ma Y...Wang Y	2017
41	Soothing Properties of Glycerol in Cough Syrups for Acute Cough Due to Common Cold. ( 28970416 )	Eccles R...Mallefet P	2017
42	Heated, humidified air for the common cold. ( 28849871 )	Singh M...Chauhan A	2017
43	Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report. ( 28837801 )	Malesker MA...CHEST Expert Cough Panel	2017
44	Is Corticosteroid of No Use for Pediatric Patients with Common Cold Undergoing Anesthesia? A Randomized, Double-Blind, Clinical Trial. ( 28824868 )	Kamranmanesh M...Gharaei B	2017
45	Trend Of Irrational Medication Among The Students Of Department Of Pharmacy Abbottabad University Of Science And Technology In Common Cold And Flu. ( 28712182 )	Rehman MU...Khan MA	2017
46	Rhinovirus - not just the common cold. ( 28646961 )	Drysdale SB...Ramilo O	2017
47	Offspring of parents who were separated and not speaking to one another have reduced resistance to the common cold as adults. ( 28584098 )	Murphy MLM...Doyle WJ	2017
48	MEWDS, Common Cold of the Retina. ( 28540002 )	Tavallali A...Yannuzzi LA	2017
49	Vaccines for the common cold. ( 28516442 )	Simancas-Racines D...Martinez-Zapata MJ	2017
50	Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. ( 28515951 )	Hemil? H	2017

Sources

Genes for Common Cold

Genes related to Common Cold (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	26.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10604558
2	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	22.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	10836321 9105080 11068660 (more) 7734976 9564459 19769802
3	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	22.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	22.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	10848925 11354638 14734451 (more) 12828863
5	RNASE3	Ribonuclease A Family Member 3	Protein Coding	21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	10836321
6	ALB	Albumin	Protein Coding	20.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	LDLR	Low Density Lipoprotein Receptor	Protein Coding	19.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	VLDLR	Very Low Density Lipoprotein Receptor	Protein Coding	19.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IFNA2	Interferon Alpha 2	Protein Coding	17.61	GeneCards inferred via : Summaries (show sections)
10	IL5	Interleukin 5	Protein Coding	17.48	DISEASES inferred ¹⁵
11	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	17.35	DISEASES inferred ¹⁵
12	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	17.14	DISEASES inferred ¹⁵ ¹⁵
13	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	16.97	DISEASES inferred ¹⁵
14	IL13	Interleukin 13	Protein Coding	16.97	DISEASES inferred ¹⁵
15	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	16.8	DISEASES inferred ¹⁵
16	IL33	Interleukin 33	Protein Coding	16.78	DISEASES inferred ¹⁵
17	POSTN	Periostin	Protein Coding	16.5	DISEASES inferred ¹⁵
18	SELP	Selectin P	Protein Coding	16.42	GeneCards inferred via : Publications (show sections)
19	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	16.42	GeneCards inferred via : Publications (show sections)
20	LPO	Lactoperoxidase	Protein Coding	6.42	GeneCards inferred via : Publications (show sections)

Sources

Variations for Common Cold

Sources

Expression for Common Cold

Search GEO for disease gene expression data for Common Cold.

Sources

Pathways for Common Cold

Pathways related to Common Cold according to GeneCards Suite gene sharing:

(show all 28)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.94	CCL11 CCL5 CXCL8 ICAM1 ICOSLG IFNA2
2	PEDF Induced Signaling ⁶⁵ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁵ Cytokine-cytokine receptor interaction ³⁸ Endothelin-1 Signaling Pathway ⁶⁵ Glucocorticoid Receptor Signaling ⁶⁵ IL-6 Pathway ⁶⁵ MIF Mediated Glucocorticoid Regulation ⁶⁵ MIF Regulation of Innate Immune Cells ⁶⁵ NFAT Signaling and Lymphocyte Interactions ⁶⁵ PGC1Alpha Pathway ⁶⁵ RAR-Gamma-RXR-Alpha Degradation ⁶⁵ STAT3 Pathway ⁶⁵	13.55	CCL11 CCL5 CXCL8 IFNA2 IL13 IL1R1
3	TGF-Beta Pathway ⁶⁵ Show member pathways JAK-STAT Pathway ⁶⁵ JNK Pathway ⁶⁵ MAPK Family Pathway ⁶⁵ Regulation of eIF4 and p70S6K ⁶⁵ SOCS Pathway ⁶⁵	13.44	CCL11 CCL5 CXCL8 ICAM1 IFNA2 IL13
4	Cytokine Signaling in Immune system ⁶⁷ Show member pathways Signaling by Interleukins ⁶⁷	13.2	CCL11 CCL5 CXCL8 ICAM1 IFNA2 IL13
5	Allograft rejection ³⁸ ¹ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.66	CCL11 CXCL8 ICAM1 ICOSLG IFNA2 IL13
6	JAK-STAT signaling pathway (KEGG) ⁶⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁷ JAK-STAT signaling pathway ³⁸	12.3	IFNA2 IL13 IL5 TSLP
7	Immune response CCR3 signaling in eosinophils ²³ Show member pathways Inhibitory action of Lipoxins on neutrophil migration ²³	12.23	CCL11 CCL5 CXCL8 ICAM1
8	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.21	ALB CCL5 ICAM1 LDLR
9	IL-17 Family Signaling Pathways ⁶⁶ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁸ Interleukin-17 signaling ⁶⁷ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.2	CCL11 CXCL8 IL13 IL5
10	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	12.13	CCL11 CCL5 CXCL8 ICAM1 IL1R1
11	Spinal Cord Injury ¹	11.89	CXCL8 ICAM1 IL1R1 SELP
12	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁶ Show member pathways Chemokine receptors bind chemokines ⁶⁷	11.88	CCL11 CCL5 CXCL8
13	Interleukin-4 and 13 signaling ⁶⁷	11.85	CCL11 CXCL8 ICAM1 IL13
14	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	11.81	CCL11 CCL5 CXCL8 ICAM1 IL13 IL1R1
15	NF-kappa B signaling pathway ³⁸	11.8	CXCL8 ICAM1 IL1R1
16	Rheumatoid arthritis ³⁸	11.75	CCL5 CXCL8 ICAM1
17	Glucocorticoid receptor regulatory network ¹	11.69	CXCL8 ICAM1 IL13 IL5
18	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁶	11.61	CCL11 CCL5 IL13
19	IL4-mediated signaling events ¹	11.52	CCL11 IL5 SELP
20	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.46	IL13 IL1R1 IL33 IL5 TSLP
21	Malaria ³⁸	11.4	CXCL8 ICAM1 SELP
22	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.37	CCL11 CXCL8 TSLP
23	Th2 Differentiation Pathway ⁶⁶	11.37	CCL11 IL13 IL33 IL5
24	Development and heterogeneity of the ILC family ¹	11.17	IL13 IL33 IL5 TSLP
25	Lung fibrosis ¹	11.15	CCL11 CCL5 CXCL8 IL13 IL5
26	G-protein signaling_RhoB regulation pathway ²³	11.09	CCL11 CCL5 CXCL8 IL13 IL5
27	G-protein signaling_Rap2B regulation pathway ²³	10.92	CCL11 CCL5 CXCL8 IL13 IL5
28	Interleukin-10 signaling ⁶⁷	10.71	CCL5 CXCL8 ICAM1 IL13 IL1R1

Sources

GO Terms for Common Cold

Cellular components related to Common Cold according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.77	ALB CCL11 CCL5 CXCL8 IFNA2 IL13
2	external side of plasma membrane	GO:0009897	9.63	ICAM1 ICOSLG IL13 IL1R1 LDLR SELP
3	extracellular space	GO:0005615	9.5	ALB CCL11 CCL5 CXCL8 ICAM1 IFNA2

Biological processes related to Common Cold according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.91	CCL11 CCL5 CXCL8 IL13 IL1R1 IL5
2	regulation of signaling receptor activity	GO:0010469	9.76	CCL11 CCL5 CXCL8 IFNA2 IL13 IL33
3	cellular response to interferon-gamma	GO:0071346	9.75	CCL11 CCL5 ICAM1
4	neutrophil chemotaxis	GO:0030593	9.72	CCL11 CCL5 CXCL8
5	positive regulation of inflammatory response	GO:0050729	9.7	IL33 LDLR TSLP
6	chemokine-mediated signaling pathway	GO:0070098	9.69	CCL11 CCL5 CXCL8
7	cellular response to interleukin-1	GO:0071347	9.67	CCL11 CCL5 CXCL8 ICAM1
8	cellular response to tumor necrosis factor	GO:0071356	9.65	CCL11 CCL5 CXCL8 ICAM1 POSTN
9	cellular response to fibroblast growth factor stimulus	GO:0044344	9.63	CCL5 CXCL8 POSTN
10	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.62	CCL5 IFNA2 IL13 TSLP
11	positive regulation of smooth muscle cell migration	GO:0014911	9.59	CCL5 POSTN
12	positive regulation of macrophage activation	GO:0043032	9.58	IL13 IL33
13	leukocyte cell-cell adhesion	GO:0007159	9.58	CCL5 ICAM1 SELP
14	negative regulation of G protein-coupled receptor signaling pathway	GO:0045744	9.57	CCL5 CXCL8
15	positive regulation of immunoglobulin secretion	GO:0051024	9.56	IL33 IL5
16	inflammatory response	GO:0006954	9.56	CCL11 CCL5 CXCL8 IFNA2 IL13 IL1R1
17	neutrophil activation	GO:0042119	9.54	CCL5 CXCL8
18	positive regulation of interleukin-13 production	GO:0032736	9.49	IL33 TSLP
19	positive regulation of interleukin-5 production	GO:0032754	9.48	IL33 TSLP
20	cytokine-mediated signaling pathway	GO:0019221	9.23	CCL11 CCL5 CXCL8 ICAM1 IFNA2 IL13

Molecular functions related to Common Cold according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:0008009	9.33	CCL11 CCL5 CXCL8
2	low-density lipoprotein particle receptor activity	GO:0005041	9.26	LDLR VLDLR
3	cytokine activity	GO:0005125	9.23	CCL11 CCL5 CXCL8 IFNA2 IL13 IL33
4	very-low-density lipoprotein particle receptor activity	GO:0030229	8.96	LDLR VLDLR

Sources

Sources for Common Cold

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Common Cold

Aliases & Classifications for Common Cold

MalaCards integrated aliases for Common Cold:

Classifications:

External Ids:

Summaries for Common Cold

Related Diseases for Common Cold

Diseases related to Common Cold via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Common Cold:

Symptoms & Phenotypes for Common Cold

UMLS symptoms related to Common Cold:

MGI Mouse Phenotypes related to Common Cold:

Drugs & Therapeutics for Common Cold

PubMedHealth treatment related to Common Cold: 64

Drugs for Common Cold (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: common cold

Genetic Tests for Common Cold

Anatomical Context for Common Cold

MalaCards organs/tissues related to Common Cold:

Publications for Common Cold

Articles related to Common Cold:

Genes for Common Cold

Genes related to Common Cold (0 elite genes):

Variations for Common Cold

Expression for Common Cold

Pathways for Common Cold

Pathways related to Common Cold according to GeneCards Suite gene sharing:

GO Terms for Common Cold

Cellular components related to Common Cold according to GeneCards Suite gene sharing:

Biological processes related to Common Cold according to GeneCards Suite gene sharing:

Molecular functions related to Common Cold according to GeneCards Suite gene sharing:

Sources for Common Cold

PubMedHealth treatment related to Common Cold: ⁶⁴

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :