MCID: CMM003
MIFTS: 32

Common Wart

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Common Wart

MalaCards integrated aliases for Common Wart:

Name: Common Wart 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:11165
ICD9CM 34 078.1
NCIt 49 C5028
SNOMED-CT 67 57019003
ICD10 32 B07.8
UMLS 71 C0043037

Summaries for Common Wart

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). This infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards based summary : Common Wart is related to epidermodysplasia verruciformis 1 and anogenital venereal wart, and has symptoms including raised wart An important gene associated with Common Wart is INSYN1 (Inhibitory Synaptic Factor 1), and among its related pathways/superpathways is Factors involved in megakaryocyte development and platelet production. The drugs Vaccines and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Related Diseases for Common Wart

Diseases related to Common Wart via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 epidermodysplasia verruciformis 1 29.3 TP53 TMC8 TMC6 PVR CD4
2 anogenital venereal wart 28.4 TP53 TLR7 PVR IFNA1 CD4
3 squamous cell papilloma 10.3
4 papilloma 10.3
5 brachial plexus neuritis 10.3 TMC8 TMC6
6 paralytic poliomyelitis 10.3 PVR CD4
7 focal epithelial hyperplasia 10.3 TMC8 TMC6
8 angiokeratoma of fordyce 10.2 TMC8 TMC6
9 plantar wart 10.1 TMC8 TMC6 PVR
10 anal carcinoma in situ 10.1 TP53 CD4
11 skin disease 10.1
12 west nile encephalitis 10.1 TLR7 CD4
13 skin papilloma 10.1 TP53 PVR
14 ulcerative stomatitis 10.1 TP53 CD4
15 combat disorder 10.1 TLR7 CD4
16 mumps 10.1
17 measles 10.1
18 rubella 10.1
19 vaginal cancer 10.1 TP53 CD4
20 coccidioidomycosis 10.1 CLEC6A CD4
21 tinea profunda 10.0 CLEC6A CLEC4E
22 anus cancer 10.0 TP53 CD4
23 squamous cell carcinoma 10.0
24 bowen's disease 10.0
25 papilledema 10.0 TP53 CD4
26 phaeohyphomycosis 9.9 CLEC6A CLEC4E
27 tinea corporis 9.9 CLEC6A CLEC4E
28 chromoblastomycosis 9.9 CLEC6A CLEC4E
29 wissler-fanconi syndrome 9.9 IFNA1 CD4
30 t-cell adult acute lymphocytic leukemia 9.9 TP53 CD4
31 skin sarcoidosis 9.9 IFNA1 CD4
32 seborrheic dermatitis 9.8 CLEC4E CD4
33 dowling-degos disease 1 9.8
34 melanoma, cutaneous malignant 10 9.8
35 pain agnosia 9.8
36 hereditary lymphedema i 9.8
37 keratosis 9.8
38 melanoma 9.8
39 dermatitis 9.8
40 verrucous papilloma 9.8
41 vaccinia 9.8
42 liposarcoma 9.8
43 skin carcinoma 9.8
44 verrucous carcinoma 9.8
45 systemic scleroderma 9.8
46 conjunctivitis 9.8
47 connective tissue disease 9.8
48 in situ carcinoma 9.8
49 actinic keratosis 9.8
50 molluscum contagiosum 9.8

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to Common Wart

Symptoms & Phenotypes for Common Wart

Symptoms:

12
  • raised wart

Drugs & Therapeutics for Common Wart

Drugs for Common Wart (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2
Ethanol Approved Phase 3 64-17-5 702
3
Zinc Approved, Investigational Phase 3 7440-66-6 32051
4
Zinc sulfate Approved, Investigational Phase 3 7733-02-0
5
Hydrogen peroxide Approved, Vet_approved Phase 3 7722-84-1 784
6 Insulin, Globin Zinc Phase 3
7 Dermatologic Agents Phase 3
8 insulin Phase 3
9 Pharmaceutical Solutions Phase 3
10 Anti-Infective Agents, Local Phase 3
11 Anti-Infective Agents Phase 3
12
Cantharidin Approved, Investigational Phase 2 56-25-7

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts : a Randomized Controlled Trial Completed NCT03183765 Phase 4 Measles-Mumps-Rubella Vaccine
2 Study to Evaluate the Efficacy of 2LVERU® JUNIOR and 2LVERU® on the Treatment of Warts. Recruiting NCT03977753 Phase 4 2LVERU® or 2LVERU® JUNIOR;Placebo
3 A Phase 3 Randomized, Double-Blind, Vehicle-Controlled, Parallel-Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Completed NCT03691831 Phase 3 A-101
4 A Phase 3 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Completed NCT03687372 Phase 3 A-101
5 Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts, A Randomized Clinical Trial Recruiting NCT03158168 Phase 3 Candida Antigen;Zinc Sulfate
6 A Phase 3 Open Label Safety Study of A-101 Topical Solution for the Treatment of Common Warts Active, not recruiting NCT03812510 Phase 3 A-101
7 Efficacy of Cryotherapy Combined With Intralesional Tuberculin Purified Protein Derivative (PPD) Versus Interlesional Tuberculin PPD Monotherapy in the Treatment of Multiple Common Warts Not yet recruiting NCT04288817 Phase 3
8 A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel for the Treatment of Common Warts in Adults Completed NCT00114920 Phase 2 Resiquimod
9 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Completed NCT03278028 Phase 2 A-101 Topical Solution;A-101 Vehicle Solution
10 A Single-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 3 Times Per Week for 4 Weeks for the Treatment of Common Warts in Pediatric Subjects Completed NCT00116675 Phase 2 Resiquimod
11 A Single-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 3 Times Per Week for up to 12 Weeks for the Treatment of Common Warts in Pediatric Subjects Completed NCT00116662 Phase 2 Resiquimod
12 A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 3 Times Per Week for 4 Weeks for the Treatment of Common Warts in Adults Completed NCT00115141 Phase 2 Resiquimod
13 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Solution in Subjects With Common Warts. Completed NCT02669862 Phase 2 A-101 Solution 40;A-101 Solution 45;Vehicle Solution
14 A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 5 Times Per Week for 4 Weeks for the Treatment of Common Warts in Adults Completed NCT00117923 Phase 2 Resiquimod
15 A Two-Stage, Single-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 5 Times Per Week for up to 12 Weeks for the Treatment of Common Warts in Adults Completed NCT00117871 Phase 2 Resiquimod
16 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Once a Week in Subjects With Common Warts Completed NCT03210337 Phase 2 A-101 Topical Solution;A-101 Vehicle Solution
17 Study of the Safety and Effectiveness of Candin for the Treatment of Common Warts Completed NCT01757392 Phase 2
18 A Phase 2, Open Label Study to Evaluate the Efficacy, Safety and Tolerability of VP-102 in Subjects With Common Warts (Verruca Vulgaris) Completed NCT03487549 Phase 2 VP-102-cantharidin topical film forming solution
19 A Double-blind, Randomized, Vehicle-controlled, Parallel-group, Phase II Dose-ranging Study to Evaluate the Efficacy and Safety of SR-T100 Gel in Common Warts (CW) Patients. Suspended NCT01796795 Phase 2 Vehicle gel;SR-T100 gel with 1.0% of SM;SR-T100 gel with 2.3% of SM
20 A Randomized, Placebo-controlled, Double-blind Phase I Study to Explore Safety, Tolerability and Pharmacodynamics of CyPep-1 in Subjects With Cutaneous Warts Recruiting NCT03846648 Phase 1 Cypep-1
21 A Phase I, Single-Centre, Open-Label, Fixed-Dose Study of the Safety and Efficacy of up- to Three-Days Application of 0.05% PEP005 Topical Gel in the Treatment of Patients With Common Wart(s) (Verruca[e] Vulgaris) on the Dorsal Hand Withdrawn NCT00546611 Phase 1 PEP005
22 Comparative Evaluation of Carbon Dioxide Laser and Cryotherapy by Dermoscopy in Treatment of Viral Wart Unknown status NCT03166137
23 Double-Blind, Randomized Control Trial To Evaluate the Efficacy of Duct Tape Versus Placebo for the Treatment of Verruca Vulgaris Completed NCT00328991
24 Nanopulse Efficacy Study for the Treatment of Common Warts Completed NCT02650466
25 Epidemiologic and Molecular Features of Cervical Cancer in Nigeria - Project Itoju (Care) Recruiting NCT00804466
26 Randomized Double Blind Study Comparing Liquid Nitrogen Cryotherapy With Nd:YAG in the Treatment of Verruca Vulgaris Terminated NCT01609530

Search NIH Clinical Center for Common Wart

Genetic Tests for Common Wart

Anatomical Context for Common Wart

The Foundational Model of Anatomy Ontology organs/tissues related to Common Wart:

19
Skin

MalaCards organs/tissues related to Common Wart:

40
Skin, Testes

Publications for Common Wart

Articles related to Common Wart:

(show top 50) (show all 75)
# Title Authors PMID Year
1
Determination of Causative Human Papillomavirus Type in Tissue Specimens of Common Warts Based on Estimated Viral Loads. 61
32039037 2020
2
Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome. 61
30633835 2019
3
Cryotherapy vs trichloroacetic acid 90% in treatment of common warts. 61
30358072 2019
4
Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis. 61
29777543 2019
5
Prevalence and factors associated with warts in primary school children in Tema District, Sohag Governorate, Egypt. 61
30774146 2019
6
Filiform Verrucous Sarcoidosis of the Face: A Warty Report. 61
29502440 2018
7
Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus. 61
29513235 2018
8
Verruca vulgaris of the buccal mucosa: A case report. 61
29516939 2018
9
[A case of combination therapy by vacuum assisted closure along with skin graft for scleroderma with common wart]. 61
27640802 2016
10
HLA Immunogenotype Determines Persistent Human Papillomavirus Virus Infection in HIV-Infected Patients Receiving Antiretroviral Treatment. 61
26908737 2016
11
Onychoheterotopia Due to a Traumatically Transplanted Nail in a Child. 61
26584701 2015
12
Monochloroacetic acid application is an effective alternative to cryotherapy for common and plantar warts in primary care: a randomized controlled trial. 61
25584800 2015
13
Hyperkeratotic acral melanoma mimicking a common wart. 61
25973355 2015
14
Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine. 61
24135577 2013
15
Treatment of recalcitrant warts with Bacillus Calmette-Guérin: a promising new approach. 61
24552412 2013
16
[Viruses as agents inducing cutaneous neoplasms]. 61
23612818 2013
17
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. 61
22277059 2013
18
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. 61
23135096 2012
19
Successful clearance of facial common warts by local hyperthermia: report of two cases. 61
22950567 2012
20
[The acrolentiginous melanoma: how to recognise and when to refer?]. 61
22914059 2012
21
HPV-associated oral warts. 61
21608502 2011
22
[The enhancement of DNA binding ability of a mutated E2 (A338V) protein of HPV-2]. 61
20572344 2010
23
Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia. 61
20083696 2010
24
Efficacy of 80% phenol solution in comparison with cryotherapy in the treatment of common warts of hands. 61
19122958 2008
25
[Transcriptional repressive activity of mutated E2 protein of human papillomavirus 2 (HPV-2) variant]. 61
18780628 2008
26
Treatment options for the common wart. 61
18210913 2007
27
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. 61
17214114 2006
28
Human papillomavirus associated with Bowen's disease of the finger. 61
15729868 2004
29
[The common wart]. 61
15026757 2004
30
Seasonal variation of dermatologic disease in the USA: a study of office visits from 1990 to 1998. 61
14693014 2004
31
Oral verruca vulgaris: report of a rare case. 61
15682794 2004
32
[Human papillomaviruses]. 61
14610898 2003
33
Duct tape removes warts. 61
12585986 2003
34
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). 61
12361440 2002
35
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? 61
12361441 2002
36
CD4+ T lymphocytopenia with disseminated HPV. 61
12207745 2002
37
Protean manifestations of human papillomavirus type 60 infection on the extremities. 61
12000390 2002
38
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. 61
11525958 2001
39
[A case of intestinal Behçet's disease with abnormal ossification complicated by myelodysplastic syndrome, symptoms revealed after the perforation of ileum ulcer]. 61
11021176 2000
40
[The CO2 laser and verruca vulgaris]. 61
11214484 2000
41
Many different papillomaviruses have low transcriptional activity in spite of strong epithelial specific enhancers. 61
10423140 1999
42
Condyloma acuminata: a fatal disease? 61
9798775 1998
43
Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. 61
8734914 1996
44
Squamous cell carcinoma in situ (Bowen's disease) mimicking subungual verruca vulgaris. 61
7931119 1994
45
Efficacy of silver nitrate pencils in the treatment of common warts. 61
8051319 1994
46
Warts and lupus erythematosus. 61
8387376 1993
47
Efficacious treatment of the common wart (verruca vulgaris). 61
1462533 1992
48
[Laser flow cytofluorimetry in the study of papilloma virus-induced lesions]. 61
1963171 1990
49
The clinical management and laboratory assessment of anal warts. 61
3037287 1987
50
The morphology of butchers' warts as related to papillomavirus types. 61
2821930 1987

Variations for Common Wart

Expression for Common Wart

Search GEO for disease gene expression data for Common Wart.

Pathways for Common Wart

Pathways related to Common Wart according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 TP53 IFNA8 IFNA1

GO Terms for Common Wart

Biological processes related to Common Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.62 IFNA8 IFNA1 CLEC6A CD4
2 T cell activation involved in immune response GO:0002286 9.26 IFNA8 IFNA1
3 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.16 IFNA8 IFNA1
4 natural killer cell activation involved in immune response GO:0002323 8.96 IFNA8 IFNA1
5 cytokine-mediated signaling pathway GO:0019221 8.92 TP53 IFNA8 IFNA1 CD4

Molecular functions related to Common Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.26 IFNA8 IFNA1
2 type I interferon receptor binding GO:0005132 9.16 IFNA8 IFNA1
3 pattern recognition receptor activity GO:0038187 8.96 TLR7 CLEC4E
4 mechanosensitive ion channel activity GO:0008381 8.62 TMC8 TMC6

Sources for Common Wart

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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