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MCID: CMM003
MIFTS: 47

Common Wart

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Common Wart

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MalaCards integrated aliases for Common Wart:

Name: Common Wart 12 15 17 74

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:11165
ICD9CM 36 078.1
NCIt 51 C27087 C5028
ICD10 34 B07 B07.8
UMLS 74 C0043037
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Summaries for Common Wart

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Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). This infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards based summary : Common Wart is related to measles and mycobacterium abscessus, and has symptoms including raised wart An important gene associated with Common Wart is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Miconazole and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and kidney, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Common Wart

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Diseases related to Common Wart via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 measles 30.1 CD209 TLR2 TLR3
2 mycobacterium abscessus 10.2 CLEC7A TLR1 TLR2
3 superficial basal cell carcinoma 10.2 TLR7 TLR8 TLR9
4 variola major 10.2 TLR3 TLR4
5 ocular toxoplasmosis 10.2 TLR1 TLR5 TLR9
6 neurosyphilis 10.2 TLR1 TLR2 TLR6
7 lyme disease 10.2 TLR1 TLR2 TLR6
8 prosthetic joint infection 10.1 TLR2 TLR4
9 juvenile nasopharyngeal angiofibroma 10.1 TLR3 TLR7 TLR9
10 coccidioidomycosis 10.1 CLEC7A TLR4
11 trench fever 10.1 TLR2 TLR4
12 bronchiolitis 10.1 TLR10 TLR4 TLR9
13 ileitis 10.0 TLR2 TLR4 TLR5
14 mumps 10.0
15 rubella 10.0
16 legionellosis 10.0 TLR2 TLR4 TLR5
17 oral cavity cancer 10.0 TLR2 TLR6 TLR9
18 acute cervicitis 10.0 TLR2 TLR4
19 mucocutaneous leishmaniasis 10.0 TLR3 TLR9
20 middle ear disease 10.0 TLR2 TLR4 TLR9
21 sulfamethoxazole allergy 10.0 CD40 CD80
22 keratitis, hereditary 10.0 TLR2 TLR4 TLR9
23 primary bacterial infectious disease 10.0 TLR2 TLR4 TLR9
24 cutaneous leishmaniasis 10.0 TLR2 TLR4 TLR9
25 legionnaires' disease 10.0 TLR4 TLR5 TLR6 TLR9
26 leishmaniasis 10.0 TLR2 TLR4 TLR9
27 mouth disease 10.0 TLR3 TLR4 TLR9
28 visceral leishmaniasis 10.0 TLR2 TLR4 TLR9
29 q fever 10.0 TLR1 TLR10 TLR2 TLR4
30 pelvic inflammatory disease 10.0 TLR1 TLR2 TLR4 TLR6
31 haemophilus influenzae 10.0 CLEC7A TLR2
32 periodontitis 9.9 TLR2 TLR4 TLR9
33 cutis laxa, autosomal dominant 1 9.9 CD80 TLR2 TLR9
34 viral infectious disease 9.9 CD209 TLR3 TLR7 TLR8 TLR9
35 suppurative otitis media 9.9 TLR2 TLR4 TLR5 TLR9
36 septic arthritis 9.9 TLR2 TLR4 TLR5 TLR9
37 pneumonia 9.9 TLR2 TLR4 TLR5 TLR9
38 opportunistic mycosis 9.9 CLEC6A CLEC7A TLR2 TLR9
39 aspergillosis 9.8 CD209 CLEC7A TLR2 TLR4 TLR9
40 toxoplasmosis 9.8 CD40 TLR2 TLR4 TLR9
41 melioidosis 9.8 TLR1 TLR10 TLR2 TLR4 TLR5
42 myd88 deficiency 9.8 TLR1 TLR2 TLR4 TLR5 TLR6
43 epidermodysplasia verruciformis 1 9.8
44 lymphedema 9.8
45 squamous cell carcinoma 9.8
46 melanoma 9.8
47 verrucous carcinoma 9.8
48 conjunctivitis 9.8
49 in situ carcinoma 9.8
50 molluscum contagiosum 9.8

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to Common Wart
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Symptoms & Phenotypes for Common Wart

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Symptoms:

12
  • • raised wart

MGI Mouse Phenotypes related to Common Wart:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CD40 CD80 CLEC4E CLEC6A CLEC7A LGALS3
2 immune system MP:0005387 9.83 CD40 CD80 CLEC4E CLEC6A CLEC7A LGALS3
3 renal/urinary system MP:0005367 9.23 CD40 CLEC6A LGALS3 TLR2 TLR4 TLR7
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Drugs & Therapeutics for Common Wart

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Drugs for Common Wart (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 22916-47-8 4189
2
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 69-72-7 338
3
Cantharidin Approved, Investigational Phase 4,Phase 2,Not Applicable 56-25-7
4
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99011-02-6 57469
5
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 32051
6
Bleomycin Approved, Investigational Phase 4 11056-06-7 5360373
7
Fluorouracil Approved Phase 4 51-21-8 3385
8
Epicatechin Investigational Phase 4,Phase 1 490-46-0, 35323-91-2 72276
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
10 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
11 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3
12 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
14 Salicylates Phase 4,Phase 2,Phase 3
15 Keratolytic Agents Phase 4,Phase 2,Phase 3,Not Applicable
16 pyruvate Phase 4,Phase 2,Phase 3
17 Analgesics Phase 4,Phase 2,Phase 3
18 Antifungal Agents Phase 4,Phase 2,Phase 3
19 Dermatologic Agents Phase 4,Phase 2,Phase 3,Not Applicable
20 Antirheumatic Agents Phase 4,Phase 2,Phase 3
21 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
22 Liver Extracts Phase 4,Phase 3
23 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Immunoglobulins Phase 4,Phase 3,Phase 1
26 Antibodies Phase 4,Phase 3,Phase 1
27 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 interferons Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Interferon Inducers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Tea Phase 4,Phase 3,Phase 2,Phase 1
33 Calcineurin Inhibitors Phase 4
34 Cyclosporins Phase 4
35 Antibodies, Monoclonal Phase 4,Phase 3,Phase 1
36 Anti-Bacterial Agents Phase 4,Phase 2
37 Trace Elements Phase 4,Phase 2,Phase 3,Not Applicable
38 Nutrients Phase 4,Phase 2,Phase 3,Not Applicable
39 Micronutrients Phase 4,Phase 2,Phase 3,Not Applicable
40 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
41 Antimetabolites Phase 4,Phase 1,Phase 2
42 Insulin, Globin Zinc Phase 4,Phase 3
43 insulin Phase 4,Phase 3
44 Antibiotics, Antitubercular Phase 4
45
Petrolatum Approved, Investigational Phase 2, Phase 3,Phase 3 8009-03-8
46
Ethanol Approved Phase 2, Phase 3,Phase 3,Not Applicable 64-17-5 702
47
Aminolevulinic acid Approved Phase 3 106-60-5 137
48
Furosemide Approved, Vet_approved Phase 3,Phase 2 54-31-9 3440
49
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
50
Pancrelipase Approved, Investigational Phase 3 53608-75-6

Interventional clinical trials:

(show top 50) (show all 214)
# Name Status NCT ID Phase Drugs
1 17% Salicylate Versus 17% Salicylate-Ethyl Pyruvate for Plantar Foot Warts Unknown status NCT01712295 Phase 4 17% Salicylate with ethyl pyruvate;Salicylates
2 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
3 Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients Unknown status NCT02624349 Phase 4 Quadravalent human papillomavirus vaccine
4 Cantharone for the Treatment of Perenial Warts Completed NCT03625960 Phase 4 Cantharidin;Trichloroacetic Acid
5 Imiquimod 5% Cream in the Treatment of External Genital or Perianal Warts in HIV+ Patients Completed NCT00761371 Phase 4 Imiquimod 5% cream
6 Study of Imiquimod Cream Prior to Ablative Therapy in External Ano-Genital Warts Completed NCT00189293 Phase 4 Imiquimod
7 Investigating Veregen â„¢ 15% Ointment Treatment For Non-facial Verrucae in Pediatric Patients: A Pilot Study Completed NCT02622568 Phase 4 Veregen only
8 Pharmacokinetic Study of Topically Applied Veregen 15% Compared With Oral Intake of Green Tea Beverage Completed NCT01082302 Phase 4 Polyphenon E (Veregen) 15% ointment
9 Alternate Dosing Schedules Study for HPV Vaccine Completed NCT00862810 Phase 4
10 Open-label Study of Subcutaneous Secukinumab to Evaluate Efficacy and Safety in Patients With Plaque Psoriasis Who Had Inadequate Response to Cyclosporine A Completed NCT02547714 Phase 4 Secukinumab (AIN457)
11 Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts Recruiting NCT03183765 Phase 4 Measles-Mumps-Rubella Vaccine
12 Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines Recruiting NCT03180034 Phase 4
13 HPV (Human Papilloma Virus) Vaccination After Treatment of Anal Intraepithelial Neoplasia (AIN) Active, not recruiting NCT02087384 Phase 4 Placebo
14 The Efficacy of Intra-lesional Bleomycin Versus Intra-lesional Purified Protein Derivative in Treatment of Palmoplantar Warts Not yet recruiting NCT03477448 Phase 4 Bleomycin;Purified Protein Derivative
15 A RTC to Examine the Effectiveness of 400 mg of Oral Zinc Gluconate as Adjunctive Therapy for Ano-genital Warts Terminated NCT01468636 Phase 4 Oral Zinc;Placebo
16 Comparison of Five Treatments in Patients With Plantar Warts Terminated NCT01059110 Phase 4 Salicylate ointment;Imiquimod;5-Fluoro-Uracil;Cryotherapy
17 Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts Unknown status NCT02151630 Phase 2, Phase 3 Pyruvic acid;Salicylic Acid
18 Efficacy of Laser Versus Cryotherapy in the Treatment of Warts Unknown status NCT01808443 Phase 3
19 Two-dose Schedule of Quadrivalent HPV Recombinant Vaccine in 11-year-old Boys in Mexico City Unknown status NCT02382900 Phase 3
20 A Study to Evaluate the Safety and Efficacy of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Completed NCT03259620 Phase 3 CLS006;CLS006 Vehicle
21 A Phase 3 Study to Evaluate the Efficacy and Safety of CLS006 Versus Vehicle in Subjects 2 Years of Age or Older With Cutaneous Common Warts Completed NCT02971891 Phase 3 CLS006 (Furosemide) Topical Gel;Vehicle Topical Gel
22 Phase 3 Study of Imiquimod Creams in the Treatment of External Genital Warts Completed NCT00735462 Phase 3 2.5% imiquimod cream;3.75% imiquimod cream;Placebo cream
23 Safety and Effectiveness Study of Imiquimod Creams in the Treatment of External Genital Warts Completed NCT00674739 Phase 3 Imiquimod;3.75% imiquimod cream;placebo cream
24 Oral Zinc Gluconate as Treatment for Recalcitrant Cutaneous Warts: A Randomized, Double-blind, Placebo-controlled Trial Completed NCT01783353 Phase 2, Phase 3
25 Low Dose Cyclophosphamide Treats Genital Warts Completed NCT00999986 Phase 3 cyclophosphamide
26 Glizigen-Viudid-External Anogenital Warts in Children and Adolescents Completed NCT01111344 Phase 3
27 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
28 Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts Completed NCT00449982 Phase 3 Polyphenon E Ointment 10%, Polyphenon E Ointment 15%
29 An Investigational Study of Gardasilâ„¢ (qHPV Vaccine) in Reducing the Incidence of Anogenital Warts in Young Men (V501-020) Completed NCT00090285 Phase 3
30 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
31 Study to Test the Safety of HPV Vaccine in Women (V501-011)(COMPLETED) Completed NCT00517309 Phase 3
32 A Controlled Trial to Assess the Immunogenicity of a Proposed Paediatric Dosing Schedule of Human Papillomavirus Vaccine Completed NCT00501137 Phase 3
33 Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil)(V501-015) Completed NCT00092534 Phase 3
34 Study of an Investigational Vaccine in Pre-Adolescents and Adolescents (Gardasil)(V501-016) Completed NCT00092495 Phase 3
35 Immunogenicity Bridge Between an Investigational Monovalent Vaccine and the Equivalent Component of Gardasil (V501) a Quadrivalent Vaccine (V501-012)(COMPLETED) Completed NCT00092482 Phase 3
36 A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASILâ„¢ (V503-006) Completed NCT01047345 Phase 3
37 Multivalent HPV (Human Papillomavirus) Vaccine Study in 16- to 26-Year Old Men and Women (V503-003) Completed NCT01651949 Phase 3
38 Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients Completed NCT00677677 Phase 3
39 Protecting Young Special Risk Females From Cervical Cancer Through Human Papilloma Virus (HPV) Vaccination Completed NCT00964210 Phase 3 Licensed quadrivalent HPV vaccine, Gardasil
40 Immunogenicity of GlaxoSmithKline Biological's Human Papillomavirus (HPV) Vaccine (580299) Versus Merck's Gardasil® in Healthy Females 18-45 Years of Age Completed NCT00423046 Phase 3
41 Topical Green Tea Ointment in Treatment of Superficial Skin Cancer Completed NCT02029352 Phase 2, Phase 3 Sinecatechins 10%;Placebo
42 Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004) Completed NCT03158220 Phase 3
43 Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) Completed NCT00543543 Phase 3
44 A Study to Evaluate the Safety, Immune Response, and Efficacy of Gardasil (V501, qHPV) in Mid-Adult Women (V501-019) Completed NCT00090220 Phase 3
45 A Study of Gardasil (V501) in Preadolescents and Adolescents (V501-018) Completed NCT00092547 Phase 3
46 GARDASILâ„¢ Study in Healthy Females Between 9 and 26 Years of Age in Sub-Saharan Africa (V501-046) Completed NCT01245764 Phase 3
47 Efficacy and Safety of Intravenous and Subcutaneous Secukinumab in Moderate to Severe Chronic Plaque-type Psoriasis Completed NCT01412944 Phase 3 secukinumab 150mg;secukinumab 10mg/kg i.v. regimen
48 Study of A-101 Topical Solution for the Treatment of Common Warts Recruiting NCT03687372 Phase 3 A-101
49 Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts Recruiting NCT03158168 Phase 3 Candida Antigen;Zinc Sulfate
50 Effectiveness Study of Human Papilloma Virus (HPV) Vaccines to Prevent Recurrence of Genital Warts Recruiting NCT02750202 Phase 3

Search NIH Clinical Center for Common Wart

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Genetic Tests for Common Wart

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Anatomical Context for Common Wart

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The Foundational Model of Anatomy Ontology organs/tissues related to Common Wart:

20
Skin

MalaCards organs/tissues related to Common Wart:

42
Skin, Kidney, Liver, Testes, Bone, T Cells
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Publications for Common Wart

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Articles related to Common Wart:

(show all 21)
# Title Authors Year
1
Hyperkeratotic acral melanoma mimicking a common wart. ( 25973355 )
2015
2
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. ( 22277059 )
2013
3
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. ( 23135096 )
2012
4
Treatment options for the common wart. ( 18210913 )
2007
5
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. ( 17214114 )
2006
6
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? ( 12361441 )
2002
7
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). ( 12361440 )
2002
8
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. ( 11525958 )
2001
9
Efficacious treatment of the common wart (verruca vulgaris). ( 1462533 )
1992
10
Common wart causing longitudinal groove in nail. ( 28150682 )
1986
11
Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema. ( 7248909 )
1981
12
Stump the experts. A common wart. ( 7338585 )
1981
13
An unusual transformation of a common wart in a child. ( 6269499 )
1981
14
The common wart: intralesional treatment with bleomycin sulfate. ( 6159138 )
1980
15
Treatment of the common wart by induced allergic inflammation. ( 7389963 )
1980
16
Treatment of the common wart with a virus vaccine. ( 14477428 )
1962
17
Morphological characterization of the virus of the human common wart (verruca vulgaris). ( 13785470 )
1961
18
Aralen and plaquenil in treatment of the common wart. ( 13726985 )
1961
19
Common wart conjunctivitis. ( 13196997 )
1954
20
Treatment of the common wart by x-ray therapy. ( 13164671 )
1954
21
Contact x-ray therapy of the common wart. ( 14914174 )
1952
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Variations for Common Wart

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Expression for Common Wart

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Search GEO for disease gene expression data for Common Wart.
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Pathways for Common Wart

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Pathways related to Common Wart according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.04 CD209 CD40 CD80 CLEC4E CLEC6A CLEC7A
2
Activated TLR4 signalling 67
Show member pathways
 13.59 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
3
Akt Signaling 65
Show member pathways
 13.46 CD40 CD80 TLR1 TLR10 TLR2 TLR3
4
Class I MHC mediated antigen processing and presentation 67
Show member pathways
 13.36 CD209 CD40 CD80 TLR1 TLR2 TLR4
5
IL-2 Pathway 65
Show member pathways
 13.29 CD40 TLR1 TLR10 TLR2 TLR3 TLR4
6
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.21 CD40 CD80 IFNA8 TLR1 TLR10 TLR2
7
NF-KappaB Family Pathway 65
Show member pathways
 12.76 CD40 TLR1 TLR10 TLR2 TLR3 TLR4
8
TRAF Pathway 65
Show member pathways
 12.7 CD40 TLR1 TLR10 TLR2 TLR3 TLR4
9
NF-kappaB Signaling 4
12.66 LGALS3 TLR1 TLR2 TLR3 TLR6 TLR7
10
Influenza A 38
Show member pathways
 12.61 CD209 IFNA8 TLR2 TLR3 TLR4 TLR7
11
VEGF Pathway (Qiagen) 65
Show member pathways
 12.55 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
12
Antigen processing-Cross presentation 67
Show member pathways
 12.38 TLR1 TLR2 TLR4 TLR6
13
Tuberculosis 38
12.36 CD209 CLEC4E CLEC7A IFNA8 TLR1 TLR2
14
CLEC7A (Dectin-1) signaling 67
Show member pathways
 12.34 CD209 CLEC4E CLEC6A CLEC7A
15
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.33 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
16
Bacterial infections in CF airways 23
Show member pathways
 12.33 TLR1 TLR2 TLR4 TLR5 TLR6 TLR7
17
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.3 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
18
C-type lectin receptor signaling pathway 38
Show member pathways
 12.28 CD209 CLEC4E CLEC6A CLEC7A TLR8 TLR9
19
Phagosome 38
12.18 CD209 CLEC7A TLR2 TLR4 TLR6
20
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.07 CD40 TLR1 TLR2 TLR4 TLR6
21
Th1 Differentiation Pathway 66
Show member pathways
 12.01 CD80 TLR1 TLR10 TLR2 TLR3 TLR4
22
Phagocytosis of Microbes 65
11.93 CLEC7A TLR1 TLR10 TLR2 TLR3 TLR4
23
Colorectal Cancer Metastasis 65
11.87 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
24
Rheumatoid arthritis 38
11.76 CD80 TLR2 TLR4
25
Dendritic Cells Developmental Lineage Pathway 66
11.66 CD209 TLR7 TLR9
26
Malaria 38
11.58 CD40 TLR2 TLR4 TLR9
27
Legionellosis 38
11.53 TLR2 TLR4 TLR5
28
MAPK Pathway 73
Show member pathways
 11.42 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
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GO Terms for Common Wart

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Cellular components related to Common Wart according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.86 CD209 CD40 CD80 CLEC4E CLEC6A CLEC7A
2 external side of plasma membrane GO:0009897 9.83 CD209 CD40 CD80 TLR4 TLR8
3 cell surface GO:0009986 9.8 CD209 CD40 CD80 LGALS3 TLR2 TLR3
4 endosome membrane GO:0010008 9.72 TLR3 TLR4 TLR7 TLR8 TLR9
5 phagocytic vesicle membrane GO:0030670 9.65 TLR1 TLR2 TLR6
6 early phagosome GO:0032009 9.46 TLR7 TLR9
7 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.4 TLR1 TLR2
8 endolysosome membrane GO:0036020 8.92 TLR3 TLR7 TLR8 TLR9
9 membrane GO:0016020 10.3 CD209 CD40 CD80 CLEC4E CLEC6A CLEC7A
10 integral component of membrane GO:0016021 10.06 CD209 CD40 CD80 CLEC4E CLEC6A CLEC7A
11 integral component of plasma membrane GO:0005887 10.04 CD40 TLR1 TLR10 TLR2 TLR3 TLR4

Biological processes related to Common Wart according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-12 production GO:0032735 9.96 CD40 TLR2 TLR3 TLR4 TLR9
2 positive regulation of tumor necrosis factor production GO:0032760 9.94 TLR2 TLR3 TLR4 TLR9
3 positive regulation of interferon-beta production GO:0032728 9.93 TLR2 TLR3 TLR4 TLR9
4 positive regulation of chemokine production GO:0032722 9.93 TLR2 TLR3 TLR4 TLR7 TLR9
5 microglial cell activation GO:0001774 9.92 TLR2 TLR3 TLR6 TLR7 TLR8
6 cellular response to interferon-gamma GO:0071346 9.91 TLR2 TLR3 TLR4
7 positive regulation of JNK cascade GO:0046330 9.91 TLR3 TLR4 TLR9
8 positive regulation of interleukin-8 production GO:0032757 9.91 TLR2 TLR3 TLR4 TLR5 TLR7 TLR9
9 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.9 CD209 CLEC4E CLEC6A
10 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.89 TLR3 TLR7 TLR8 TLR9
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TLR4 TLR5 TLR6
12 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.88 TLR4 TLR7 TLR8 TLR9
13 positive regulation of B cell proliferation GO:0030890 9.87 CD40 TLR4 TLR9
14 I-kappaB phosphorylation GO:0007252 9.85 TLR2 TLR3 TLR4 TLR7 TLR9
15 positive regulation of interleukin-10 production GO:0032733 9.84 TLR2 TLR4 TLR9
16 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.83 TLR3 TLR4 TLR6
17 toll-like receptor 9 signaling pathway GO:0034162 9.83 TLR7 TLR8 TLR9
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.83 TLR2 TLR4 TLR9
19 cell activation GO:0001775 9.82 TLR1 TLR2 TLR6
20 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.81 TLR3 TLR7 TLR8 TLR9
21 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.81 TLR1 TLR10 TLR2 TLR4 TLR5 TLR6
22 positive regulation of toll-like receptor signaling pathway GO:0034123 9.8 TLR2 TLR3 TLR5 TLR9
23 positive regulation of interferon-beta biosynthetic process GO:0045359 9.8 TLR3 TLR4 TLR7 TLR8 TLR9
24 defense response to protozoan GO:0042832 9.75 CD40 CLEC7A
25 necroptotic process GO:0070266 9.75 TLR3 TLR4
26 activation of NF-kappaB-inducing kinase activity GO:0007250 9.74 TLR3 TLR6
27 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.74 TLR4 TLR6
28 positive regulation of macrophage activation GO:0043032 9.74 TLR4 TLR6
29 positive regulation of interleukin-8 secretion GO:2000484 9.74 TLR1 TLR2
30 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.74 TLR4 TLR6
31 response to molecule of bacterial origin GO:0002237 9.74 TLR2 TLR9
32 macrophage activation GO:0042116 9.73 TLR1 TLR4
33 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.73 TLR3 TLR4
34 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.73 TLR1 TLR4
35 cellular response to lipoteichoic acid GO:0071223 9.73 TLR2 TLR4
36 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.73 TLR4 TLR6
37 interleukin-1 beta secretion GO:0050702 9.72 TLR4 TLR6
38 regulation of T cell proliferation GO:0042129 9.72 CD209 LGALS3
39 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.71 TLR3 TLR4
40 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 TLR1 TLR6
41 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.71 TLR4 TLR6
42 positive regulation of interleukin-18 production GO:0032741 9.71 TLR2 TLR9
43 tumor necrosis factor production GO:0032640 9.7 TLR2 TLR9
44 cellular response to diacyl bacterial lipopeptide GO:0071726 9.7 TLR2 TLR6
45 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.7 TLR2 TLR6
46 cellular response to triacyl bacterial lipopeptide GO:0071727 9.69 TLR1 TLR2
47 nitric oxide metabolic process GO:0046209 9.69 TLR2 TLR6
48 positive regulation of oxidative stress-induced neuron death GO:1903223 9.68 TLR4 TLR6
49 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.68 TLR1 TLR2
50 detection of diacyl bacterial lipopeptide GO:0042496 9.68 TLR2 TLR6

Molecular functions related to Common Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.76 CD40 CLEC4E TLR1 TLR2 TLR3 TLR4
2 carbohydrate binding GO:0030246 9.72 CD209 CLEC4E CLEC6A CLEC7A LGALS3
3 double-stranded RNA binding GO:0003725 9.61 TLR3 TLR7 TLR8
4 interleukin-1 receptor binding GO:0005149 9.48 TLR5 TLR9
5 siRNA binding GO:0035197 9.46 TLR7 TLR9
6 lipopeptide binding GO:0071723 9.43 TLR1 TLR2 TLR6
7 lipopolysaccharide receptor activity GO:0001875 9.4 TLR2 TLR4
8 Toll-like receptor 2 binding GO:0035663 9.37 TLR1 TLR6
9 signaling pattern recognition receptor activity GO:0008329 9.35 CLEC7A TLR2 TLR7 TLR8 TLR9
10 transmembrane signaling receptor activity GO:0004888 9.28 TLR1 TLR10 TLR3 TLR4 TLR5 TLR6
Sources

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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