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MCID: CMM003
MIFTS: 32

Common Wart

Categories: Infectious diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Common Wart

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MalaCards integrated aliases for Common Wart:

Name: Common Wart 12 15 17 72

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11165
ICD9CM 35 078.1
NCIt 50 C27087 C5028
ICD10 33 B07 B07.8
UMLS 72 C0043037
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Summaries for Common Wart

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Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in human papillomavirus (types 2 and 4). This infection has symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

MalaCards based summary : Common Wart is related to anogenital venereal wart and measles, and has symptoms including raised wart An important gene associated with Common Wart is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Tuberculosis and Phagocytosis of Microbes. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes.

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Related Diseases for Common Wart

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Diseases related to Common Wart via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 anogenital venereal wart 29.6 TLR7 IFNB1
2 measles 29.5 IFNB1 CD209
3 papilloma 10.3
4 squamous cell papilloma 10.3
5 fungal keratitis 10.2 CLEC7A CD209
6 skin disease 10.1
7 marburg hemorrhagic fever 10.1 IFNB1 CD209
8 rubella 10.1
9 mumps 10.1
10 epidermodysplasia verruciformis 1 10.1
11 bowen's disease 10.0
12 squamous cell carcinoma 10.0
13 aspergillosis 10.0 CLEC7A CD209
14 japanese encephalitis 10.0 IFNB1 CD209
15 severe acute respiratory syndrome 9.9 IFNB1 CD209
16 septicemic plague 9.8 TLR7 IFNB1
17 lymphedema 9.8
18 primary lymphedema 9.8
19 bowenoid papulosis 9.8
20 molluscum contagiosum 9.8
21 actinic keratosis 9.8
22 in situ carcinoma 9.8
23 connective tissue disease 9.8
24 conjunctivitis 9.8
25 systemic scleroderma 9.8
26 verrucous carcinoma 9.8
27 skin carcinoma 9.8
28 liposarcoma 9.8
29 vaccinia 9.8
30 verrucous papilloma 9.8
31 dermatitis 9.8
32 melanoma 9.8
33 keratosis 9.8
34 chronic erythremia 9.8
35 pain agnosia 9.8
36 dowling-degos disease 1 9.8
37 herpangina 9.8 TLR7 IFNB1
38 viral infectious disease 9.5 TLR7 IFNB1 CD209

Graphical network of the top 20 diseases related to Common Wart:



Diseases related to Common Wart
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Symptoms & Phenotypes for Common Wart

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Symptoms:

12
  • • raised wart
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Drugs & Therapeutics for Common Wart

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Drugs for Common Wart (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4
3
Zinc Approved, Investigational Phase 3 7440-66-6 32051
4
Zinc sulfate Approved, Investigational Phase 3 7733-02-0
5
Hydrogen peroxide Approved, Vet_approved Phase 3 7722-84-1 784
6
Ethanol Approved Phase 3 64-17-5 702
7 insulin Phase 3
8 Insulin, Globin Zinc Phase 3
9 Nutrients Phase 3
10 Micronutrients Phase 3
11 Dermatologic Agents Phase 3
12 Trace Elements Phase 3
13 Astringents Phase 3
14 Pharmaceutical Solutions Phase 3
15 Anti-Infective Agents Phase 3
16 Anti-Infective Agents, Local Phase 3
17 Central Nervous System Depressants Phase 3
18
Cantharidin Approved, Investigational Phase 2 56-25-7

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts : a Randomized Controlled Trial Unknown status NCT03183765 Phase 4 Measles-Mumps-Rubella Vaccine
2 Randomized Study to Evaluate 2LVERU® JUNIOR and 2LVERU® on the Treatment of Warts. Not yet recruiting NCT03977753 Phase 4 2LVERU® or 2LVERU® JUNIOR
3 A Phase 3 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Recruiting NCT03687372 Phase 3 A-101
4 Intralesional Candidal Antigen Versus Intralesional Zinc Sulphate in Treatment of Cutaneous Warts, A Randomized Clinical Trial Recruiting NCT03158168 Phase 3 Candida Antigen;Zinc Sulfate
5 A Phase 3 Open Label Safety Study of A-101 Topical Solution for the Treatment of Common Warts Active, not recruiting NCT03812510 Phase 3 A-101
6 A Phase 3 Randomized, Double-Blind, Vehicle-Controlled, Parallel-Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Active, not recruiting NCT03691831 Phase 3 A-101
7 A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel for the Treatment of Common Warts in Adults Completed NCT00114920 Phase 2 Resiquimod
8 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Completed NCT03278028 Phase 2 A-101 Topical Solution;A-101 Vehicle Solution
9 A Single-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 3 Times Per Week for 4 Weeks for the Treatment of Common Warts in Pediatric Subjects Completed NCT00116675 Phase 2 Resiquimod
10 A Single-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 3 Times Per Week for up to 12 Weeks for the Treatment of Common Warts in Pediatric Subjects Completed NCT00116662 Phase 2 Resiquimod
11 A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 3 Times Per Week for 4 Weeks for the Treatment of Common Warts in Adults Completed NCT00115141 Phase 2 Resiquimod
12 A Three-Stage, Modified-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 5 Times Per Week for 4 Weeks for the Treatment of Common Warts in Adults Completed NCT00117923 Phase 2 Resiquimod
13 A Two-Stage, Single-Blind, Dose-Escalating Study to Assess Efficacy and Safety of Resiquimod Gel Applied 5 Times Per Week for up to 12 Weeks for the Treatment of Common Warts in Adults Completed NCT00117871 Phase 2 Resiquimod
14 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Solution in Subjects With Common Warts. Completed NCT02669862 Phase 2 A-101 Solution 40;A-101 Solution 45;Vehicle Solution
15 A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Once a Week in Subjects With Common Warts Completed NCT03210337 Phase 2 A-101 Topical Solution;A-101 Vehicle Solution
16 Study of the Safety and Effectiveness of Candin for the Treatment of Common Warts Completed NCT01757392 Phase 2
17 A Phase 2, Open Label Study to Evaluate the Efficacy, Safety and Tolerability of VP-102 in Subjects With Common Warts (Verruca Vulgaris) Completed NCT03487549 Phase 2 VP-102-cantharidin topical film forming solution
18 A Double-blind, Randomized, Vehicle-controlled, Parallel-group, Phase II Dose-ranging Study to Evaluate the Efficacy and Safety of SR-T100 Gel in Common Warts (CW) Patients. Suspended NCT01796795 Phase 2 Vehicle gel;SR-T100 gel with 1.0% of SM;SR-T100 gel with 2.3% of SM
19 A Randomized, Placebo-controlled, Double-blind Phase I Study to Explore Safety, Tolerability and Pharmacodynamics of CyPep-1 in Subjects With Cutaneous Warts Recruiting NCT03846648 Phase 1 Cypep-1
20 A Phase I, Single-Centre, Open-Label, Fixed-Dose Study of the Safety and Efficacy of up- to Three-Days Application of 0.05% PEP005 Topical Gel in the Treatment of Patients With Common Wart(s) (Verruca[e] Vulgaris) on the Dorsal Hand Withdrawn NCT00546611 Phase 1 PEP005
21 Comparative Evaluation of Carbon Dioxide Laser and Cryotherapy by Dermoscopy in Treatment of Viral Wart Unknown status NCT03166137
22 Double-Blind, Randomized Control Trial To Evaluate the Efficacy of Duct Tape Versus Placebo for the Treatment of Verruca Vulgaris Completed NCT00328991
23 Nanopulse Efficacy Study for the Treatment of Common Warts Completed NCT02650466
24 Epidemiologic and Molecular Features of Cervical Cancer in Nigeria - Project Itoju (Care) Active, not recruiting NCT00804466
25 Randomized Double Blind Study Comparing Liquid Nitrogen Cryotherapy With Nd:YAG in the Treatment of Verruca Vulgaris Terminated NCT01609530

Search NIH Clinical Center for Common Wart

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Genetic Tests for Common Wart

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Anatomical Context for Common Wart

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The Foundational Model of Anatomy Ontology organs/tissues related to Common Wart:

19
Skin

MalaCards organs/tissues related to Common Wart:

41
Skin, Testes
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Publications for Common Wart

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Articles related to Common Wart:

(show top 50) (show all 74)
# Title Authors PMID Year
1
Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome. 38
30633835 2019
2
Cryotherapy vs trichloroacetic acid 90% in treatment of common warts. 38
30358072 2019
3
Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis. 38
29777543 2019
4
Prevalence and factors associated with warts in primary school children in Tema District, Sohag Governorate, Egypt. 38
30774146 2019
5
Filiform Verrucous Sarcoidosis of the Face: A Warty Report. 38
29502440 2018
6
Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus. 38
29513235 2018
7
Verruca vulgaris of the buccal mucosa: A case report. 38
29516939 2018
8
[A case of combination therapy by vacuum assisted closure along with skin graft for scleroderma with common wart]. 38
27640802 2016
9
HLA Immunogenotype Determines Persistent Human Papillomavirus Virus Infection in HIV-Infected Patients Receiving Antiretroviral Treatment. 38
26908737 2016
10
Onychoheterotopia Due to a Traumatically Transplanted Nail in a Child. 38
26584701 2015
11
Monochloroacetic acid application is an effective alternative to cryotherapy for common and plantar warts in primary care: a randomized controlled trial. 38
25584800 2015
12
Hyperkeratotic acral melanoma mimicking a common wart. 38
25973355 2015
13
Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine. 38
24135577 2013
14
Treatment of recalcitrant warts with Bacillus Calmette-Guérin: a promising new approach. 38
24552412 2013
15
[Viruses as agents inducing cutaneous neoplasms]. 38
23612818 2013
16
Keratotic horn on left fifth fingertip: congenital ectopic nail misdiagnosed as a common wart. 38
22277059 2013
17
Comparative study of topical 80% trichloroacetic acid with 35% trichloroacetic acid in the treatment of the common wart. 38
23135096 2012
18
Successful clearance of facial common warts by local hyperthermia: report of two cases. 38
22950567 2012
19
[The acrolentiginous melanoma: how to recognise and when to refer?]. 38
22914059 2012
20
HPV-associated oral warts. 38
21608502 2011
21
[The enhancement of DNA binding ability of a mutated E2 (A338V) protein of HPV-2]. 38
20572344 2010
22
Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia. 38
20083696 2010
23
Efficacy of 80% phenol solution in comparison with cryotherapy in the treatment of common warts of hands. 38
19122958 2008
24
[Transcriptional repressive activity of mutated E2 protein of human papillomavirus 2 (HPV-2) variant]. 38
18780628 2008
25
Treatment options for the common wart. 38
18210913 2007
26
Plantar verrucous carcinoma (epithelloma cuniculatum): rare form of the common wart. 38
17214114 2006
27
Human papillomavirus associated with Bowen's disease of the finger. 38
15729868 2004
28
[The common wart]. 38
15026757 2004
29
Seasonal variation of dermatologic disease in the USA: a study of office visits from 1990 to 1998. 38
14693014 2004
30
Oral verruca vulgaris: report of a rare case. 38
15682794 2004
31
[Human papillomaviruses]. 38
14610898 2003
32
Duct tape removes warts. 38
12585986 2003
33
Is duct tape occlusion therapy as effective as cryotherapy for the treatment of the common wart? 38
12361441 2002
34
The efficacy of duct tape vs cryotherapy in the treatment of verruca vulgaris (the common wart). 38
12361440 2002
35
CD4+ T lymphocytopenia with disseminated HPV. 38
12207745 2002
36
Protean manifestations of human papillomavirus type 60 infection on the extremities. 38
12000390 2002
37
Human papillomavirus associated Bowen's disease of the foot: unique clinical features mimicking a common wart. 38
11525958 2001
38
[A case of intestinal Behçet's disease with abnormal ossification complicated by myelodysplastic syndrome, symptoms revealed after the perforation of ileum ulcer]. 38
11021176 2000
39
[The CO2 laser and verruca vulgaris]. 38
11214484 2000
40
Many different papillomaviruses have low transcriptional activity in spite of strong epithelial specific enhancers. 38
10423140 1999
41
Condyloma acuminata: a fatal disease? 38
9798775 1998
42
Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. 38
8734914 1996
43
Squamous cell carcinoma in situ (Bowen's disease) mimicking subungual verruca vulgaris. 38
7931119 1994
44
Efficacy of silver nitrate pencils in the treatment of common warts. 38
8051319 1994
45
Warts and lupus erythematosus. 38
8387376 1993
46
Efficacious treatment of the common wart (verruca vulgaris). 38
1462533 1992
47
[Laser flow cytofluorimetry in the study of papilloma virus-induced lesions]. 38
1963171 1990
48
The clinical management and laboratory assessment of anal warts. 38
3037287 1987
49
The morphology of butchers' warts as related to papillomavirus types. 38
2821930 1987
50
Common wart causing longitudinal groove in nail. 38
28150682 1986
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Variations for Common Wart

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Expression for Common Wart

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Search GEO for disease gene expression data for Common Wart.
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Pathways for Common Wart

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Pathways related to Common Wart according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Tuberculosis 37
11.38 IFNB1 CLEC7A CD209
2
Phagocytosis of Microbes 64
11.09 TLR7 CLEC7A
3
Dendritic Cells Developmental Lineage Pathway 65
10.67 TLR7 IFNB1 CD209
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GO Terms for Common Wart

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Biological processes related to Common Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 8.8 TLR7 CLEC7A CD209

Molecular functions related to Common Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.13 TLR7 FZD3 BCAM
2 signaling pattern recognition receptor activity GO:0008329 8.62 TLR7 CLEC7A
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Sources for Common Wart

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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