MCID: CMM008
MIFTS: 38

Communicating Hydrocephalus

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Communicating Hydrocephalus

MalaCards integrated aliases for Communicating Hydrocephalus:

Name: Communicating Hydrocephalus 12 30 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1573
ICD9CM 36 331.3
MeSH 45 D006849
NCIt 51 C34501
SNOMED-CT 69 59013007
ICD10 34 G91.0
UMLS 74 C0009451

Summaries for Communicating Hydrocephalus

MalaCards based summary : Communicating Hydrocephalus is related to hydrocephalus and hydrocephalus, normal-pressure. An important gene associated with Communicating Hydrocephalus is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Alzheimers Disease Pathway. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Communicating Hydrocephalus

Diseases in the Communicating Hydrocephalus family:

Congenital Communicating Hydrocephalus

Diseases related to Communicating Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 30.2 APOE HYDIN MAPT PTGDS SFMBT1 TGFB1
2 hydrocephalus, normal-pressure 29.8 APOE DNAH14 FRMD4A MAPT MS4A6A OGG1
3 intracranial hypertension, idiopathic 29.7 AQP4 OGG1
4 congenital communicating hydrocephalus 12.4
5 congenital non-communicating hydrocephalus 12.3
6 hydrocephalus, endocardial fibroelastosis, and cataracts 11.8
7 kozlowski brown hardwick syndrome 11.6
8 congenital hydrocephalus 11.6
9 thoracic dysplasia-hydrocephalus syndrome 11.1
10 coenurosis 11.1
11 cole-carpenter syndrome 11.1
12 dementia 10.2
13 intracranial hypotension 10.1 OGG1 PTGDS
14 meningitis 10.1
15 neurilemmoma 10.1
16 acoustic neuroma 10.0
17 intracranial hypertension 10.0
18 glioblastoma 10.0
19 simultanagnosia 10.0 APOE MAPT
20 posterior cortical atrophy 10.0 APOE MAPT
21 systemic lupus erythematosus 9.9
22 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.9
23 benign ependymoma 9.9
24 lupus erythematosus 9.9
25 ependymoma 9.9
26 glioma 9.9
27 semantic dementia 9.9 APOE MAPT
28 kohlschutter-tonz syndrome 9.9 APOE MAPT
29 alzheimer disease mitochondrial 9.9 APOE MAPT
30 glioma susceptibility 1 9.9
31 cerebellar hypoplasia 9.9
32 lymphatic malformation 7 9.9
33 arachnoiditis 9.9
34 papilledema 9.9
35 gaucher's disease 9.9
36 glioblastoma multiforme 9.9
37 arachnoid cysts 9.9
38 fetal edema 9.9
39 hydrops fetalis 9.9
40 transposition of the great arteries 9.9
41 cerebral atrophy 9.9
42 alzheimer disease 2 9.8 APOE MAPT SERPINA3
43 cerebral amyloid angiopathy, cst3-related 9.8 APOE MAPT SERPINA3
44 binswanger's disease 9.8 APOE MAPT
45 vascular dementia 9.8 APOE MAPT SERPINA3
46 creutzfeldt-jakob disease 9.8 APOE MAPT SERPINA3
47 alexia 9.8 APOE AQP4
48 brain injury 9.7 APOE MAPT
49 seizures, benign familial neonatal, 1 9.7
50 cryoglobulinemia, familial mixed 9.7

Comorbidity relations with Communicating Hydrocephalus via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Hypertension, Essential Hypothyroidism
Obstructive Hydrocephalus Parkinson Disease, Late-Onset
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Communicating Hydrocephalus:



Diseases related to Communicating Hydrocephalus

Symptoms & Phenotypes for Communicating Hydrocephalus

MGI Mouse Phenotypes related to Communicating Hydrocephalus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 APOE AQP4 HYDIN MAPT NEFL OGG1
2 nervous system MP:0003631 9.23 APOE AQP4 HYDIN MAPT NEFL OGG1

Drugs & Therapeutics for Communicating Hydrocephalus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
2 Third Ventriculostomy Versus Shunt for Children With Hydrocephalus Completed NCT01801267 Not Applicable
3 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life Completed NCT01367977
4 Improved Analysis Methods for Infusion Tests Completed NCT01319136
5 Keyhole Surgery for the Positioning of the Distal Catheter in Ventricular Peritoneal Shunt Placement Completed NCT01739179
6 Study of Choroid Plexus Cauderization in Patients With Hydrocephalus Recruiting NCT02900222 Not Applicable
7 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138 Not Applicable
8 ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus Terminated NCT00946127
9 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life Withdrawn NCT01377805

Search NIH Clinical Center for Communicating Hydrocephalus

Genetic Tests for Communicating Hydrocephalus

Genetic tests related to Communicating Hydrocephalus:

# Genetic test Affiliating Genes
1 Communicating Hydrocephalus 30

Anatomical Context for Communicating Hydrocephalus

MalaCards organs/tissues related to Communicating Hydrocephalus:

42
Brain, Testes, Spinal Cord, B Cells, Bone, Pituitary

Publications for Communicating Hydrocephalus

Articles related to Communicating Hydrocephalus:

(show top 50) (show all 318)
# Title Authors Year
1
Lumboperitoneal and Ventriculoperitoneal Shunt Surgery for Posthemorrhagic Communicating Hydrocephalus: A Comparison. ( 30947009 )
2019
2
Symptomatic communicating hydrocephalus in a contemporary cohort of high grade glioma patients. ( 29160137 )
2018
3
Compound heterozygous variants in the multiple PDZ domain protein (MPDZ) cause a case of mild non-progressive communicating hydrocephalus. ( 29499638 )
2018
4
Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele. ( 29678699 )
2018
5
Spastic Quadriparesis and Communicating Hydrocephalus as Late Sequel of Rosai-Dorfman Disease: A Case Report and Review of Literature. ( 29682050 )
2018
6
Communicating hydrocephalus and coexisting nonenhancing tumor: An ominous sign for patients with neurofibromatosis type 1? ( 29682141 )
2018
7
FSI simulation of CSF hydrodynamic changes in a large population of non-communicating hydrocephalus patients during treatment process with regard to their clinical symptoms. ( 29708982 )
2018
8
Endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) in non-communicating hydrocephalus (NCH): comparison of outcome profiles in Nigerian children. ( 29860541 )
2018
9
Ventriculoperitoneal Shunts Equipped with On-Off Valves for Intraventricular Therapies in Patients with Communicating Hydrocephalus due to Leptomeningeal Metastases. ( 30110924 )
2018
10
Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model. ( 30217783 )
2018
11
Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report. ( 30532732 )
2018
12
Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension. ( 30560499 )
2018
13
Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis comparable with mechanisms seen in inflammatory pathways? Part I: historical observations and clinical perspectives on the etiology of increased CSF protein levels, CSF clotting, and communicating hydrocephalus: a comprehensive review. ( 28265819 )
2018
14
Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans. ( 28575905 )
2017
15
Intraventricular administration of urokinase as a novel therapeutic approach for communicating hydrocephalus. ( 27614013 )
2017
16
Cerebrospinal fluid dynamics study in communicating hydrocephalus. ( 28484522 )
2017
17
Secondary communicating hydrocephalus management by implantation of external ventricular shunt and minimal gradual increase of cerebrospinal fluid pressure. ( 28484529 )
2017
18
"Pure" Suprasellar Schwannoma Presented with Communicating Hydrocephalus: A Case Report. ( 28840085 )
2017
19
Communicating Hydrocephalus Onset Following a Traumatic Tension Pneumocephalus. ( 28913289 )
2016
20
Communicating hydrocephalus, a long-term complication of dural tear during lumbar spine surgery. ( 26521076 )
2016
21
Communicating Hydrocephalus Associated with Intracranial Schwannoma Treated by Gamma Knife Radiosurgery. ( 26585729 )
2016
22
Evaluation of the flow of cerebrospinal fluid as well as gender and age characteristics in patients with communicating hydrocephalus, using phase-contrast magnetic resonance imaging. ( 26848963 )
2016
23
Imaging of Communicating Hydrocephalus. ( 27063660 )
2016
24
New concept of the pathogenesis and therapeutic orientation of acquired communicating hydrocephalus. ( 27115894 )
2016
25
Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. ( 27246837 )
2016
26
Communicating Hydrocephalus Due to Traumatic Lumbar Spine Injury: Case Report and Literature Review. ( 27323322 )
2016
27
Ventricular Volume Load Reveals the Mechanoelastic Impact of Communicating Hydrocephalus on Dynamic Cerebral Autoregulation. ( 27415784 )
2016
28
Communicating Hydrocephalus Associated with Small- to Medium-Sized Vestibular Schwannomas: Clinical Significance of the Tumor Apparent Diffusion Coefficient Map. ( 27423198 )
2016
29
The prevalence of cardiovascular disease in non-communicating hydrocephalus. ( 27455422 )
2016
30
Analysis of risk factors to predict communicating hydrocephalus following gamma knife radiosurgery for intracranial schwannoma. ( 27882725 )
2016
31
Persistent communicating hydrocephalus in adult tuberous sclerosis patients: a possible therapeutic role for everolimus. ( 25524658 )
2015
32
A hypothesis of traumatic subdural effusion associated with communicating hydrocephalus in infants and its management. ( 25675020 )
2015
33
Association between ventricular volume measures and pulsatile and static intracranial pressure scores in non-communicating hydrocephalus. ( 25680584 )
2015
34
Surgical management of non-communicating hydrocephalus in patients: meta-analysis and comparison of endoscopic third ventriculostomy and ventriculoperitoneal shunt. ( 25699529 )
2015
35
A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus. ( 27708931 )
2015
36
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. ( 23512254 )
2014
37
Hearing loss following ventriculoperitoneal shunt in communicating hydrocephalus patients: a pilot study. ( 24318317 )
2014
38
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
39
Communicating hydrocephalus with reversible cognitive impairment. ( 24589982 )
2014
40
Early manifestation of communicating hydrocephalus after fractionated stereotactic radiotherapy for aggressive giant atypical prolactinoma. ( 24778068 )
2014
41
Microgravity environment and compensatory: Decompensatory phases for intracranial hypertension form new perspectives to explain mechanism underlying communicating hydrocephalus and its related disorders. ( 24891884 )
2014
42
Pemetrexed and communicating hydrocephalus. ( 24940146 )
2014
43
Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus. ( 24996196 )
2014
44
Communicating hydrocephalus in systemic lupus erythematosus. ( 25031142 )
2014
45
Communicating hydrocephalus caused by an unruptured perimedullary arteriovenous fistula in the lumbar region of an infant. ( 23240850 )
2013
46
Aqueductal flow of cerebrospinal fluid (CSF) and anatomical configuration of the cerebral aqueduct (AC) in patients with communicating hydrocephalus--the trumpet sign. ( 23318053 )
2013
47
Thrombin-induced TGF-β1 pathway: a cause of communicating hydrocephalus post subarachnoid hemorrhage. ( 23338707 )
2013
48
Is endoscopic third ventriculostomy superior to shunts in patients with non-communicating hydrocephalus? A systematic review and meta-analysis of the evidence. ( 23456239 )
2013
49
Molecular targets for neonatal communicating hydrocephalus, putting shunts out to pasture? ( 23511831 )
2013
50
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus. ( 23560698 )
2013

Variations for Communicating Hydrocephalus

Expression for Communicating Hydrocephalus

Search GEO for disease gene expression data for Communicating Hydrocephalus.

Pathways for Communicating Hydrocephalus

Pathways related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 APOE MAPT

GO Terms for Communicating Hydrocephalus

Cellular components related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 APOE SERPINA3 TGFB1

Biological processes related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.54 APOE MAPT TGFB1
2 negative regulation of blood vessel endothelial cell migration GO:0043537 9.32 APOE TGFB1
3 response to radiation GO:0009314 9.26 OGG1 TGFB1
4 axon development GO:0061564 9.16 MAPT NEFL
5 positive regulation of superoxide anion generation GO:0032930 8.96 MAPT TGFB1
6 axonal transport of mitochondrion GO:0019896 8.62 MAPT NEFL

Molecular functions related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 9.13 FRMD4A MAPT NEFL
2 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Communicating Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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