MCID: CMM008
MIFTS: 35

Communicating Hydrocephalus

Categories: Neuronal diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Communicating Hydrocephalus

MalaCards integrated aliases for Communicating Hydrocephalus:

Name: Communicating Hydrocephalus 12 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1573
ICD10 33 G91.0
ICD9CM 35 331.3
MeSH 44 D006849
NCIt 50 C34501
SNOMED-CT 68 271569006 59013007
UMLS 73 C0009451

Summaries for Communicating Hydrocephalus

MalaCards based summary : Communicating Hydrocephalus is related to hydrocephalus and hydrocephalus, normal-pressure. An important gene associated with Communicating Hydrocephalus is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways is Alzheimers Disease Pathway. Affiliated tissues include testes, brain and b cells.

Related Diseases for Communicating Hydrocephalus

Diseases in the Communicating Hydrocephalus family:

Congenital Communicating Hydrocephalus

Diseases related to Communicating Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 29.5 APOE HYDIN MAPT PTGDS SFMBT1 TGFB1
2 hydrocephalus, normal-pressure 24.8 APOE ASRGL1 DNAH14 FRMD4A MAPT MS4A6A
3 congenital communicating hydrocephalus 12.2
4 congenital non-communicating hydrocephalus 12.1
5 hydrocephalus, endocardial fibroelastosis, and cataracts 11.6
6 kozlowski brown hardwick syndrome 11.4
7 chiari malformation type i 10.9
8 coenurosis 10.9
9 cole-carpenter syndrome 10.9
10 chiari malformation 10.9
11 congenital hydrocephalus 10.9
12 diabetic foot ulcers 10.2 APOE TGFB1
13 simultanagnosia 10.2 APOE MAPT
14 posterior cortical atrophy 10.2 APOE MAPT
15 familial idiopathic basal ganglia calcification 10.1 APOE MAPT
16 cerebritis 10.1
17 semantic dementia 10.1 APOE MAPT
18 dementia 10.0
19 meningitis 10.0
20 binswanger's disease 10.0 APOE MAPT
21 arachnoiditis 10.0
22 brain injury 9.9 APOE MAPT
23 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.9
24 choroiditis 9.9
25 glioblastoma 9.9
26 systemic lupus erythematosus 9.8
27 lupus erythematosus 9.8
28 intracranial hypertension 9.8
29 ependymoma 9.8
30 glioma 9.8
31 aneurysm 9.8
32 cerebral amyloid angiopathy, cst3-related 9.8 APOE MAPT
33 glioma susceptibility 1 9.7
34 cerebellar hypoplasia 9.7
35 intracranial hypertension, idiopathic 9.7
36 hydrops fetalis, nonimmune, and/or atrial septal defect 9.7
37 papilledema 9.7
38 gaucher's disease 9.7
39 glioblastoma multiforme 9.7
40 arachnoid cysts 9.7
41 fetal edema 9.7
42 hydrops fetalis 9.7
43 transposition of the great arteries 9.7
44 cerebral atrophy 9.7
45 aphasia 9.6 APOE MAPT
46 cryoglobulinemia, familial mixed 9.6
47 neurofibromatosis, type i 9.6
48 neurofibromatosis, type iv, of riccardi 9.6
49 schizophrenia 9.6
50 tetralogy of fallot 9.6

Comorbidity relations with Communicating Hydrocephalus via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Hypertension, Essential Hypothyroidism
Obstructive Hydrocephalus Parkinson Disease, Late-Onset
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Communicating Hydrocephalus:



Diseases related to Communicating Hydrocephalus

Symptoms & Phenotypes for Communicating Hydrocephalus

Drugs & Therapeutics for Communicating Hydrocephalus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
2 Third Ventriculostomy Versus Shunt for Children With Hydrocephalus Completed NCT01801267 Not Applicable
3 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life Completed NCT01367977
4 Improved Analysis Methods for Infusion Tests Completed NCT01319136
5 Keyhole Surgery for the Positioning of the Distal Catheter in Ventricular Peritoneal Shunt Placement Completed NCT01739179
6 Study of Choroid Plexus Cauderization in Patients With Hydrocephalus Recruiting NCT02900222 Not Applicable
7 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138 Not Applicable
8 ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus Terminated NCT00946127
9 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life Withdrawn NCT01377805

Search NIH Clinical Center for Communicating Hydrocephalus

Genetic Tests for Communicating Hydrocephalus

Genetic tests related to Communicating Hydrocephalus:

# Genetic test Affiliating Genes
1 Communicating Hydrocephalus 29

Anatomical Context for Communicating Hydrocephalus

MalaCards organs/tissues related to Communicating Hydrocephalus:

41
Testes, Brain, B Cells, Spinal Cord

Publications for Communicating Hydrocephalus

Articles related to Communicating Hydrocephalus:

(show top 50) (show all 307)
# Title Authors Year
1
Compound heterozygous variants in the multiple PDZ domain protein (MPDZ) cause a case of mild non-progressive communicating hydrocephalus. ( 29499638 )
2018
2
Spastic Quadriparesis and Communicating Hydrocephalus as Late Sequel of Rosai-Dorfman Disease: A Case Report and Review of Literature. ( 29682050 )
2018
3
Endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) in non-communicating hydrocephalus (NCH): comparison of outcome profiles in Nigerian children. ( 29860541 )
2018
4
FSI simulation of CSF hydrodynamic changes in a large population of non-communicating hydrocephalus patients during treatment process with regard to their clinical symptoms. ( 29708982 )
2018
5
Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele. ( 29678699 )
2018
6
Communicating hydrocephalus and coexisting nonenhancing tumor: An ominous sign for patients with neurofibromatosis type 1? ( 29682141 )
2018
7
Cerebrospinal fluid dynamics study in communicating hydrocephalus. ( 28484522 )
2017
8
Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis comparable with mechanisms seen in inflammatory pathways? Part I: historical observations and clinical perspectives on the etiology of increased CSF protein levels, CSF clotting, and communicating hydrocephalus: a comprehensive review. ( 28265819 )
2017
9
Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans. ( 28575905 )
2017
10
Symptomatic communicating hydrocephalus in a contemporary cohort of high grade glioma patients. ( 29160137 )
2017
11
"Pure" Suprasellar Schwannoma Presented with Communicating Hydrocephalus: A Case Report. ( 28840085 )
2017
12
Secondary communicating hydrocephalus management by implantation of external ventricular shunt and minimal gradual increase of cerebrospinal fluid pressure. ( 28484529 )
2017
13
Imaging of Communicating Hydrocephalus. ( 27063660 )
2016
14
Communicating hydrocephalus associated with small- to medium-sized vestibular schwannomas: clinical significance of the tumor apparent diffusion coefficient map. ( 27423198 )
2016
15
Communicating Hydrocephalus Due to Traumatic Lumbar Spine Injury: Case Report and Literature Review. ( 27323322 )
2016
16
The prevalence of cardiovascular disease in non-communicating hydrocephalus. ( 27455422 )
2016
17
New concept of the pathogenesis and therapeutic orientation of acquired communicating hydrocephalus. ( 27115894 )
2016
18
Communicating Hydrocephalus Onset Following a Traumatic Tension Pneumocephalus. ( 28913289 )
2016
19
Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. ( 27246837 )
2016
20
Evaluation of the flow of cerebrospinal fluid as well as gender and age characteristics in patients with communicating hydrocephalus, using phase-contrast magnetic resonance imaging. ( 26848963 )
2016
21
Ventricular Volume Load Reveals the Mechanoelastic Impact of Communicating Hydrocephalus on Dynamic Cerebral Autoregulation. ( 27415784 )
2016
22
Intraventricular administration of urokinase as a novel therapeutic approach for communicating hydrocephalus. ( 27614013 )
2016
23
Communicating Hydrocephalus Associated with Intracranial Schwannoma Treated by Gamma Knife Radiosurgery. ( 26585729 )
2016
24
Analysis of risk factors to predict communicating hydrocephalus following gamma knife radiosurgery for intracranial schwannoma. ( 27882725 )
2016
25
Persistent communicating hydrocephalus in adult tuberous sclerosis patients: a possible therapeutic role for everolimus. ( 25524658 )
2015
26
Surgical management of non-communicating hydrocephalus in patients: meta-analysis and comparison of endoscopic third ventriculostomy and ventriculoperitoneal shunt. ( 25699529 )
2015
27
Association between ventricular volume measures and pulsatile and static intracranial pressure scores in non-communicating hydrocephalus. ( 25680584 )
2015
28
Communicating hydrocephalus, a long-term complication of dural tear during lumbar spine surgery. ( 26521076 )
2015
29
A hypothesis of traumatic subdural effusion associated with communicating hydrocephalus in infants and its management. ( 25675020 )
2015
30
A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus. ( 27708931 )
2015
31
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. ( 23512254 )
2014
32
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
33
Microgravity environment and compensatory: Decompensatory phases for intracranial hypertension form new perspectives to explain mechanism underlying communicating hydrocephalus and its related disorders. ( 24891884 )
2014
34
Communicating hydrocephalus with reversible cognitive impairment. ( 24589982 )
2014
35
Communicating hydrocephalus in systemic lupus erythematosus. ( 25031142 )
2014
36
Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus. ( 24996196 )
2014
37
Early manifestation of communicating hydrocephalus after fractionated stereotactic radiotherapy for aggressive giant atypical prolactinoma. ( 24778068 )
2014
38
Pemetrexed and communicating hydrocephalus. ( 24940146 )
2014
39
Decorin prevents the development of juvenile communicating hydrocephalus. ( 23983032 )
2013
40
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus. ( 23560698 )
2013
41
Molecular targets for neonatal communicating hydrocephalus, putting shunts out to pasture? ( 23511831 )
2013
42
Gravity assisted vs. medium pressure valves for communicating hydrocephalus show similar valve-revision rates. ( 23989996 )
2013
43
Thrombin-induced TGF-I^1 pathway: a cause of communicating hydrocephalus post subarachnoid hemorrhage. ( 23338707 )
2013
44
Clinical characteristics and neuroimaging findings in 12 cases of recurrent glioblastoma with communicating hydrocephalus. ( 23883558 )
2013
45
Comparative study of lumboperitoneal shunt versus ventriculoperitoneal shunt in post meningitis communicating hydrocephalus in children. ( 24262455 )
2013
46
Hearing loss following ventriculoperitoneal shunt in communicating hydrocephalus patients: a pilot study. ( 24318317 )
2013
47
Communicating hydrocephalus and vestibular schwannomas: etiology, treatment, and long-term follow-up. ( 24436891 )
2013
48
Aqueductal flow of cerebrospinal fluid (CSF) and anatomical configuration of the cerebral aqueduct (AC) in patients with communicating hydrocephalus--the trumpet sign. ( 23318053 )
2013
49
Communicating hydrocephalus accompanied by arachnoid cyst in aneurismal subarachnoid hemorrhage. ( 24729958 )
2013
50
Is endoscopic third ventriculostomy superior to shunts in patients with non-communicating hydrocephalus? A systematic review and meta-analysis of the evidence. ( 23456239 )
2013

Variations for Communicating Hydrocephalus

Expression for Communicating Hydrocephalus

Search GEO for disease gene expression data for Communicating Hydrocephalus.

Pathways for Communicating Hydrocephalus

Pathways related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 APOE MAPT

GO Terms for Communicating Hydrocephalus

Cellular components related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 APOE SERPINA3 TGFB1

Biological processes related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.43 APOE MAPT TGFB1
2 negative regulation of blood vessel endothelial cell migration GO:0043537 9.16 APOE TGFB1
3 response to radiation GO:0009314 8.96 OGG1 TGFB1
4 positive regulation of superoxide anion generation GO:0032930 8.62 MAPT TGFB1

Molecular functions related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Communicating Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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