MCID: CMM008
MIFTS: 38

Communicating Hydrocephalus

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Communicating Hydrocephalus

MalaCards integrated aliases for Communicating Hydrocephalus:

Name: Communicating Hydrocephalus 12 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1573
ICD10 33 G91.0
ICD9CM 35 331.3
MeSH 44 D006849
NCIt 50 C34501
SNOMED-CT 68 59013007
UMLS 73 C0009451

Summaries for Communicating Hydrocephalus

MalaCards based summary : Communicating Hydrocephalus is related to hydrocephalus and hydrocephalus, normal-pressure. An important gene associated with Communicating Hydrocephalus is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways is Alzheimers Disease Pathway. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Communicating Hydrocephalus

Diseases in the Communicating Hydrocephalus family:

Congenital Communicating Hydrocephalus

Diseases related to Communicating Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 30.9 APOE HYDIN MAPT PTGDS SFMBT1 TGFB1
2 hydrocephalus, normal-pressure 30.6 APOE ASRGL1 DNAH14 FRMD4A MAPT MS4A6A
3 intracranial hypertension, idiopathic 29.7 AQP4 OGG1
4 congenital communicating hydrocephalus 12.4
5 congenital non-communicating hydrocephalus 12.2
6 hydrocephalus, endocardial fibroelastosis, and cataracts 11.8
7 kozlowski brown hardwick syndrome 11.6
8 congenital hydrocephalus 11.4
9 chiari malformation type i 11.1
10 chiari malformation type ii 11.1
11 thoracic dysplasia-hydrocephalus syndrome 11.1
12 coenurosis 11.1
13 cole-carpenter syndrome 11.1
14 chiari malformation 11.1
15 dementia 10.1
16 intracranial hypotension 10.1 OGG1 PTGDS
17 simultanagnosia 10.1 APOE MAPT
18 posterior cortical atrophy 10.1 APOE MAPT
19 meningitis 10.1
20 familial idiopathic basal ganglia calcification 10.1 APOE MAPT
21 semantic dementia 10.1 APOE MAPT
22 kohlschutter-tonz syndrome 10.0 APOE MAPT
23 binswanger's disease 10.0 APOE MAPT
24 glioblastoma 10.0
25 alexia 10.0 APOE AQP4
26 brain injury 9.9 APOE MAPT
27 systemic lupus erythematosus 9.9
28 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.9
29 lupus erythematosus 9.9
30 intracranial hypertension 9.9
31 ependymoma 9.9
32 glioma 9.9
33 alzheimer disease 2 9.9 APOE MAPT
34 traumatic brain injury 9.9 APOE AQP4
35 nervous system disease 9.8 APOE AQP4 MAPT
36 glioma susceptibility 1 9.8
37 cerebellar hypoplasia 9.8
38 hydrops fetalis, nonimmune, and/or atrial septal defect 9.8
39 arachnoiditis 9.8
40 papilledema 9.8
41 gaucher's disease 9.8
42 glioblastoma multiforme 9.8
43 arachnoid cysts 9.8
44 fetal edema 9.8
45 hydrops fetalis 9.8
46 transposition of the great arteries 9.8
47 cerebral atrophy 9.8
48 central nervous system disease 9.8 APOE AQP4 MAPT
49 cryoglobulinemia, familial mixed 9.7
50 neurofibromatosis, type i 9.7

Comorbidity relations with Communicating Hydrocephalus via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Hypertension, Essential Hypothyroidism
Obstructive Hydrocephalus Parkinson Disease, Late-Onset
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Communicating Hydrocephalus:



Diseases related to Communicating Hydrocephalus

Symptoms & Phenotypes for Communicating Hydrocephalus

MGI Mouse Phenotypes related to Communicating Hydrocephalus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 APOE AQP4 HYDIN MAPT OGG1 PTGDS
2 nervous system MP:0003631 9.23 APOE AQP4 HYDIN MAPT OGG1 PTGDS

Drugs & Therapeutics for Communicating Hydrocephalus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
2 Third Ventriculostomy Versus Shunt for Children With Hydrocephalus Completed NCT01801267 Not Applicable
3 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life Completed NCT01367977
4 Improved Analysis Methods for Infusion Tests Completed NCT01319136
5 Keyhole Surgery for the Positioning of the Distal Catheter in Ventricular Peritoneal Shunt Placement Completed NCT01739179
6 Study of Choroid Plexus Cauderization in Patients With Hydrocephalus Recruiting NCT02900222 Not Applicable
7 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138 Not Applicable
8 ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus Terminated NCT00946127
9 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life Withdrawn NCT01377805

Search NIH Clinical Center for Communicating Hydrocephalus

Genetic Tests for Communicating Hydrocephalus

Genetic tests related to Communicating Hydrocephalus:

# Genetic test Affiliating Genes
1 Communicating Hydrocephalus 29

Anatomical Context for Communicating Hydrocephalus

MalaCards organs/tissues related to Communicating Hydrocephalus:

41
Testes, Brain, Spinal Cord, B Cells, Bone

Publications for Communicating Hydrocephalus

Articles related to Communicating Hydrocephalus:

(show top 50) (show all 315)
# Title Authors Year
1
Compound heterozygous variants in the multiple PDZ domain protein (MPDZ) cause a case of mild non-progressive communicating hydrocephalus. ( 29499638 )
2018
2
Spastic Quadriparesis and Communicating Hydrocephalus as Late Sequel of Rosai-Dorfman Disease: A Case Report and Review of Literature. ( 29682050 )
2018
3
Endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) in non-communicating hydrocephalus (NCH): comparison of outcome profiles in Nigerian children. ( 29860541 )
2018
4
FSI simulation of CSF hydrodynamic changes in a large population of non-communicating hydrocephalus patients during treatment process with regard to their clinical symptoms. ( 29708982 )
2018
5
Acute Communicating Hydrocephalus as Spinal Cord Surgery Complication in Patient with Lumbar Lipomyelocele. ( 29678699 )
2018
6
Communicating hydrocephalus and coexisting nonenhancing tumor: An ominous sign for patients with neurofibromatosis type 1? ( 29682141 )
2018
7
Ventriculoperitoneal Shunts Equipped with On-Off Valves for Intraventricular Therapies in Patients with Communicating Hydrocephalus due to Leptomeningeal Metastases. ( 30110924 )
2018
8
Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model. ( 30217783 )
2018
9
Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report. ( 30532732 )
2018
10
Cerebrospinal fluid dynamics study in communicating hydrocephalus. ( 28484522 )
2017
11
Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis comparable with mechanisms seen in inflammatory pathways? Part I: historical observations and clinical perspectives on the etiology of increased CSF protein levels, CSF clotting, and communicating hydrocephalus: a comprehensive review. ( 28265819 )
2017
12
Association of White Matter Lesions, Cerebral Atrophy, Intracranial Extravascular Calcifications, and Ventricular-Communicating Hydrocephalus with Delirium Among Veterans. ( 28575905 )
2017
13
Symptomatic communicating hydrocephalus in a contemporary cohort of high grade glioma patients. ( 29160137 )
2017
14
"Pure" Suprasellar Schwannoma Presented with Communicating Hydrocephalus: A Case Report. ( 28840085 )
2017
15
Secondary communicating hydrocephalus management by implantation of external ventricular shunt and minimal gradual increase of cerebrospinal fluid pressure. ( 28484529 )
2017
16
Imaging of Communicating Hydrocephalus. ( 27063660 )
2016
17
Communicating hydrocephalus associated with small- to medium-sized vestibular schwannomas: clinical significance of the tumor apparent diffusion coefficient map. ( 27423198 )
2016
18
Communicating Hydrocephalus Due to Traumatic Lumbar Spine Injury: Case Report and Literature Review. ( 27323322 )
2016
19
The prevalence of cardiovascular disease in non-communicating hydrocephalus. ( 27455422 )
2016
20
New concept of the pathogenesis and therapeutic orientation of acquired communicating hydrocephalus. ( 27115894 )
2016
21
Communicating Hydrocephalus Onset Following a Traumatic Tension Pneumocephalus. ( 28913289 )
2016
22
Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. ( 27246837 )
2016
23
Evaluation of the flow of cerebrospinal fluid as well as gender and age characteristics in patients with communicating hydrocephalus, using phase-contrast magnetic resonance imaging. ( 26848963 )
2016
24
Ventricular Volume Load Reveals the Mechanoelastic Impact of Communicating Hydrocephalus on Dynamic Cerebral Autoregulation. ( 27415784 )
2016
25
Intraventricular administration of urokinase as a novel therapeutic approach for communicating hydrocephalus. ( 27614013 )
2016
26
Communicating Hydrocephalus Associated with Intracranial Schwannoma Treated by Gamma Knife Radiosurgery. ( 26585729 )
2016
27
Analysis of risk factors to predict communicating hydrocephalus following gamma knife radiosurgery for intracranial schwannoma. ( 27882725 )
2016
28
Persistent communicating hydrocephalus in adult tuberous sclerosis patients: a possible therapeutic role for everolimus. ( 25524658 )
2015
29
Surgical management of non-communicating hydrocephalus in patients: meta-analysis and comparison of endoscopic third ventriculostomy and ventriculoperitoneal shunt. ( 25699529 )
2015
30
Association between ventricular volume measures and pulsatile and static intracranial pressure scores in non-communicating hydrocephalus. ( 25680584 )
2015
31
Communicating hydrocephalus, a long-term complication of dural tear during lumbar spine surgery. ( 26521076 )
2015
32
A hypothesis of traumatic subdural effusion associated with communicating hydrocephalus in infants and its management. ( 25675020 )
2015
33
A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus. ( 27708931 )
2015
34
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. ( 23512254 )
2014
35
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
36
Microgravity environment and compensatory: Decompensatory phases for intracranial hypertension form new perspectives to explain mechanism underlying communicating hydrocephalus and its related disorders. ( 24891884 )
2014
37
Communicating hydrocephalus with reversible cognitive impairment. ( 24589982 )
2014
38
Communicating hydrocephalus in systemic lupus erythematosus. ( 25031142 )
2014
39
Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus. ( 24996196 )
2014
40
Early manifestation of communicating hydrocephalus after fractionated stereotactic radiotherapy for aggressive giant atypical prolactinoma. ( 24778068 )
2014
41
Pemetrexed and communicating hydrocephalus. ( 24940146 )
2014
42
Decorin prevents the development of juvenile communicating hydrocephalus. ( 23983032 )
2013
43
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus. ( 23560698 )
2013
44
Molecular targets for neonatal communicating hydrocephalus, putting shunts out to pasture? ( 23511831 )
2013
45
Gravity assisted vs. medium pressure valves for communicating hydrocephalus show similar valve-revision rates. ( 23989996 )
2013
46
Thrombin-induced TGF-I^1 pathway: a cause of communicating hydrocephalus post subarachnoid hemorrhage. ( 23338707 )
2013
47
Clinical characteristics and neuroimaging findings in 12 cases of recurrent glioblastoma with communicating hydrocephalus. ( 23883558 )
2013
48
Comparative study of lumboperitoneal shunt versus ventriculoperitoneal shunt in post meningitis communicating hydrocephalus in children. ( 24262455 )
2013
49
Hearing loss following ventriculoperitoneal shunt in communicating hydrocephalus patients: a pilot study. ( 24318317 )
2013
50
Communicating hydrocephalus and vestibular schwannomas: etiology, treatment, and long-term follow-up. ( 24436891 )
2013

Variations for Communicating Hydrocephalus

Expression for Communicating Hydrocephalus

Search GEO for disease gene expression data for Communicating Hydrocephalus.

Pathways for Communicating Hydrocephalus

Pathways related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 APOE MAPT

GO Terms for Communicating Hydrocephalus

Biological processes related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.43 APOE MAPT TGFB1
2 negative regulation of blood vessel endothelial cell migration GO:0043537 9.16 APOE TGFB1
3 response to radiation GO:0009314 8.96 OGG1 TGFB1
4 positive regulation of superoxide anion generation GO:0032930 8.62 MAPT TGFB1

Molecular functions related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Communicating Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....