MCID: CMM008
MIFTS: 45

Communicating Hydrocephalus

Categories: Fetal diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Communicating Hydrocephalus

MalaCards integrated aliases for Communicating Hydrocephalus:

Name: Communicating Hydrocephalus 12 29 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1573
ICD9CM 34 331.3
MeSH 43 D006849
NCIt 49 C34501
SNOMED-CT 67 271569006
ICD10 32 G91.0
UMLS 71 C0009451

Summaries for Communicating Hydrocephalus

MalaCards based summary : Communicating Hydrocephalus is related to normal pressure hydrocephalus and intracranial hypertension. An important gene associated with Communicating Hydrocephalus is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Neuroscience. The drug Mitogens has been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are behavior/neurological and integument

Related Diseases for Communicating Hydrocephalus

Diseases in the Communicating Hydrocephalus family:

Hydrocephalus, Congenital Communicating, 1 Congenital Communicating Hydrocephalus

Diseases related to Communicating Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 normal pressure hydrocephalus 30.9 SFMBT1 SERPINA3 PTGDS MIR4274 MAPT LRG1
2 intracranial hypertension 30.8 SERPINA3 AQP4 AQP1
3 acoustic neuroma 30.6 TGFB1 AQP4 AQP1
4 arachnoiditis 30.5 ASPRV1 AQP4
5 obstructive hydrocephalus 30.5 ZIC3 AQP4 AQP1
6 apraxia 30.3 SLC6A3 MAPT APOE
7 binswanger's disease 30.1 MAPT APP APOE
8 cerebrovascular disease 30.0 SERPINA3 MAPT APP APOE
9 neuroma 29.9 TGFB1 SERPINA3 AQP4 AQP1
10 dementia 29.7 SNCA SLC6A3 SERPINA3 MAPT APP APOE
11 vascular dementia 29.7 SERPINA3 NEFL MAPT APP APOE
12 intracranial hypertension, idiopathic 29.7 PTGDS ASPRV1 AQP4 AQP1
13 hydrocephalus 28.9 ZIC3 TGFB1 SLC6A3 SFMBT1 SERPINA3 PTGDS
14 parkinson disease, late-onset 28.9 SNCA SLC6A3 SERPINA3 NEFL MAPT APP
15 congenital communicating hydrocephalus 12.5
16 hydrocephalus, endocardial fibroelastosis, and cataracts 11.9
17 hydrocephalus, congenital, 1 11.9
18 kozlowski brown hardwick syndrome 11.7
19 congenital hydrocephalus 11.5
20 thoracic dysplasia-hydrocephalus syndrome 11.5
21 hydrocephalus with cerebellar agenesis 11.5
22 cole-carpenter syndrome 11.5
23 mucopolysaccharidosis, type vi 11.2
24 coenurosis 11.2
25 cerebellar ataxia type 47 10.5 SERPINA3 ERCC6
26 residual stage of open angle glaucoma 10.5 APP APOE
27 posterior cortical atrophy 10.5 MAPT APOE
28 senile plaque formation 10.5 APP APOE
29 semantic dementia 10.4 MAPT APOE
30 alzheimer's disease 1 10.4 APP APOE
31 finger agnosia 10.4 MAPT ADAMTS2
32 degeneration of macula and posterior pole 10.4 SERPINA3 ERCC6 APOE
33 alzheimer disease 10 10.4 MAPT APOE
34 primary lateral sclerosis, adult, 1 10.4 SNCA MAPT
35 subependymoma 10.3 AQP4 AQP1
36 age-related hearing loss 10.3 MAPT APOE
37 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.3 SERPINA3 APP APOE
38 dysferlinopathy 10.3 AQP4 AQP1
39 cranial nerve disease 10.3 SERPINA3 ERCC6 AQP4
40 gerstmann syndrome 10.3 MAPT APOE ADAMTS2
41 simultanagnosia 10.3 MAPT APOE ADAMTS2
42 visual agnosia 10.3 MAPT APOE ADAMTS2
43 nominal aphasia 10.3 MAPT APOE ADAMTS2
44 basal ganglia calcification 10.3 MAPT ERCC6 APP
45 amnestic disorder 10.3 MAPT APP APOE
46 neuritis 10.3 MAPT AQP4 APOE
47 bullous keratopathy 10.3 TGFB1 AQP4 AQP1
48 amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 10.3 SNCA MAPT ERCC6
49 cerebellar disease 10.3 SNCA SERPINA3 ERCC6
50 combined oxidative phosphorylation deficiency 7 10.3 SNCA AQP4

Comorbidity relations with Communicating Hydrocephalus via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Hypertension, Essential Hypothyroidism
Obstructive Hydrocephalus Parkinson Disease, Late-Onset
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Communicating Hydrocephalus:



Diseases related to Communicating Hydrocephalus

Symptoms & Phenotypes for Communicating Hydrocephalus

MGI Mouse Phenotypes related to Communicating Hydrocephalus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 APOE APP AQP1 AQP4 ERCC6 MAPT
2 integument MP:0010771 10 ADAMTS2 APOE APP ASPRV1 ERCC6 MAPT
3 nervous system MP:0003631 9.97 APOE APP AQP1 AQP4 ERCC6 MAPT
4 skeleton MP:0005390 9.61 ADAMTS2 APOE AQP1 ERCC6 PTGDS SLC6A3
5 taste/olfaction MP:0005394 8.92 APOE MAPT SLC6A3 SNCA

Drugs & Therapeutics for Communicating Hydrocephalus

Drugs for Communicating Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Lumbar Drainage for Communicating Hydrocephalus After Intraventricular Hemorrhage: a Randomised, Controlled Trial(LUCAS-IVH: LUmbar CAtheter for Severe IntraVentricular Hemorrhage) Completed NCT01041950 Phase 2, Phase 3
2 A Randomized Controlled Trial of Endoscopic Third Ventriculostomy Versus Ventricular Shunt for Children With Communicating Hydrocephalus Completed NCT01801267
3 Novel Infusion Method for Describing CSF Dynamics Completed NCT01319136
4 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia ("POTS" -- Postural Orthostatic Tachycardia Syndrome)Later in Life -- a Retrospective Analysis Completed NCT01367977
5 Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus Completed NCT00600795
6 Laparoscopically Assisted Ventriculoperitoneal Shunt Placement: A Prospective, Randomized Two-arm Study Completed NCT01739179
7 Alterations in Cerebral Perfusion, Oxygenation, Electrical Activity, and Markers of Cerebral Damage Associated With Cerebro-spinal Fluid Reservior Aspiration in Neonates With Post Hemorrhagic Hydrocephalus Completed NCT00747682
8 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138
9 Assessment of Cerebrospinal Fluid Flow Related Disorders Using a Phase-contrast Magnetic Resonance Imaging Technique. Recruiting NCT03656016
10 Study of Endoscopic Choroid Plexus Cauterization for Adult Patients With Hydrocephalus and Risk Factors for Perioperative Complications Following Shunt Surgery. Recruiting NCT02900222
11 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633
12 Endoscopic Third Ventriculostomy (ETV) Versus Ventriculoperitoneal Shunting (VPS) for the Surgical Management of Normal Pressure Hydrocephalus Terminated NCT00946127
13 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life -- a Retrospective Analysis Withdrawn NCT01377805

Search NIH Clinical Center for Communicating Hydrocephalus

Genetic Tests for Communicating Hydrocephalus

Genetic tests related to Communicating Hydrocephalus:

# Genetic test Affiliating Genes
1 Communicating Hydrocephalus 29

Anatomical Context for Communicating Hydrocephalus

MalaCards organs/tissues related to Communicating Hydrocephalus:

40
Brain, Testes, Spinal Cord, Pineal, Bone, Heart, Bone Marrow

Publications for Communicating Hydrocephalus

Articles related to Communicating Hydrocephalus:

(show top 50) (show all 1126)
# Title Authors PMID Year
1
Inflammatory cytokine cascade released by leukocytes in cerebrospinal fluid after subarachnoid hemorrhage. 61 54
11680512 2001
2
Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage: titers derived from exogenous and endogenous sources. 61 54
11176281 2001
3
Study of cerebrospinal fluid flow dynamics in TGF-beta 1 induced chronic hydrocephalic mice. 61 54
10763513 2000
4
Ultramicroscopic structures of the leptomeninx of mice with communicating hydrocephalus induced by human recombinant transforming growth factor-beta 1. 54 61
10063355 1998
5
Elevation of transforming growth factor-beta 1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. 54 61
8023355 1994
6
Induction of communicating hydrocephalus in mice by intrathecal injection of human recombinant transforming growth factor-beta 1. 54 61
8120136 1994
7
uPA alleviates kaolin-induced hydrocephalus by promoting the release and activation of hepatocyte growth factor in rats. 61
32497735 2020
8
Refractory communicating hydrocephalus after radiation for small vestibular schwannoma with asymptomatic ventriculomegaly: A case report. 61
32435322 2020
9
Complex management of hydrocephalus secondary to choroid plexus hyperplasia. 61
32497849 2020
10
Management of pineal region tumors in a pediatric case series. 61
32504201 2020
11
Three-Dimensionally Printed Microelectromechanical-System Hydrogel Valve for Communicating Hydrocephalus. 61
32141291 2020
12
The efficacy of endoscopic third ventriculostomy in children 1 year of age or younger: A systematic review and meta-analysis. 61
32139243 2020
13
Ruptured Arteriovenous Malformation Anterior to the Brainstem to a Child with Subsequent Spontaneous Thrombosis: Case Report and Literature Review. 61
32355154 2020
14
Sinus Pericranii Complicated by Hydrocephalus: Case Report and Literature Review. 61
32330617 2020
15
Utilization Behavior Associated with Communicating Hydrocephalus with Resolution Post-Ventriculoperitoneal Shunting. 61
32258237 2020
16
Diffuse leptomeningeal glioneuronal tumour (DLGNT) with hydrocephalus as an initial symptom: a case-based update. 61
31897629 2020
17
Intrathecal nusinersen treatment after ventriculo-peritoneal shunt placement: A case report focusing on the neurofilament light chain in cerebrospinal fluid. 61
31889567 2020
18
Management of idiopathic normal pressure hydrocephalus (iNPH) - a retrospective study. 61
32046512 2020
19
Hydrocephalus as the presenting symptom of sarcoidosis: A case report and review of literature. 61
32128190 2020
20
Extrusion of the Distal Catheter From the Umbilicus: A Case Report of a Rare Complication After Ventriculoperitoneal Shunt and Its Management. 61
32528915 2020
21
[Neuroendoscopic interventions using an Nd-YAG laser for multilevel hydrocephalus: treatment results for 10 patients]. 61
32207740 2020
22
Leptomeningeal dissemination of low-grade neuroepithelial CNS tumors in adults: a 15-year experience. 61
32257290 2020
23
Efficacy and Safety of Lumboperitoneal Shunt in the Treatment of All-Cause Communicating Hydrocephalus: Analysis of Risk Factors of Shunt Failure. 61
31226460 2019
24
Neurobrucellosis in a 9-year-old girl. 61
32184924 2019
25
Neurosarcoidosis presenting with isolated intracranial mass lesion and communicating hydrocephalus. 61
31882303 2019
26
Endoscopic third ventriculostomy in children with third ventricular pressure gradient and open ventricular outlets on MRI. 61
31654263 2019
27
Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus. 61
31865917 2019
28
Isolated leptomeningeal carcinomatosis and possible fungal meningitis as late sequelae of oesophageal adenocarcinoma. 61
31678919 2019
29
Communicating hydrocephalus after radiosurgery for vestibular schwannomas: does technique matter? A systematic review and meta-analysis. 61
31621039 2019
30
Hydrocephalus Secondary to Intradural Extramedullary Malignant Melanoma of Spinal Cord. 61
31302270 2019
31
Acute Stroke in Tubercular Meningitis: A Case Report. 61
32329473 2019
32
[Extra-ventricular drainage for the treatment of pneumococcal meningitis and hydrocephalus: a case report]. 61
31474646 2019
33
Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration. 61
31121363 2019
34
Relationship between intracranial pressure and phase-contrast cine MRI-derived measures of cerebrospinal fluid parameters in communicating hydrocephalus. 61
31559170 2019
35
Myxopapillary ependymoma of cauda equina presented with communicating hydrocephalus and papilloedema: A case report. 61
31424046 2019
36
Spinal paraganglioma presenting as normal pressure hydrocephalus: a rare occurrence. 61
31317776 2019
37
Endoscopic Third Ventriculostomy in Cases of Ventriculoperitoneal Shunt Malfunction: Does Shunt Duration Play a Role? 61
30954740 2019
38
Lumboperitoneal and Ventriculoperitoneal Shunt Surgery for Posthemorrhagic Communicating Hydrocephalus: A Comparison. 61
30947009 2019
39
AQP1 Overexpression in the CSF of Obstructive Hydrocephalus and Inversion of Its Polarity in the Choroid Plexus of a Chiari Malformation Type II Case. 61
31039249 2019
40
The effect of ventricular volume increase in the amplitude of intracranial pressure. 61
30931613 2019
41
Hydrocephalus due to a Cavernoma-Like Lesion of an Obliterated Cerebral Arteriovenous Malformation Treated by Embolization and Radiosurgery. 61
30885872 2019
42
Anatomical characterization of the inferior petrosal sinus and adjacent cerebellopontine angle cistern for development of an endovascular transdural cerebrospinal fluid shunt. 61
30626626 2019
43
Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension. 61
30560499 2019
44
Fetoscopic spina bifida repair. 61
30486637 2019
45
Hydrocephalus after Gamma Knife Radiosurgery for Schwannoma. 61
31143267 2019
46
Choroidal artery embolization in the management of cerebrospinal fluid overproduction: case report and review of the literature. 61
30901750 2019
47
Leptomeningeal Carcinomatosis as the Initial Manifestation of Metastatic Disease diagnosed in Postmortem Examination: A Case Series. 61
30924918 2019
48
Surgical Management of Isolated Fourth Ventricular Hydrocephalus Associated with Injury to the Guillain-Mollaret Triangle. 61
30368016 2019
49
Association of Severe Hydrocephalus With Congenital Zika Syndrome. 61
30452526 2019
50
The value of CSF flow studies in the management of CSF disorders in children: a pictorial review. 61
30689061 2019

Variations for Communicating Hydrocephalus

Expression for Communicating Hydrocephalus

Search GEO for disease gene expression data for Communicating Hydrocephalus.

Pathways for Communicating Hydrocephalus

Pathways related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 ZIC3 TGFB1 SFMBT1 APP
2 11.89 SNCA NEFL MAPT APP APOE
3 11.1 SNCA MAPT APP APOE
4 10.99 MAPT APP APOE

GO Terms for Communicating Hydrocephalus

Cellular components related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.87 TGFB1 SNCA MAPT AQP4 AQP1 APP
2 neuron projection GO:0043005 9.85 SNPH SLC6A3 NEFL MAPT APP
3 extracellular region GO:0005576 9.85 TGFB1 SNCA SERPINA3 PTGDS MAPT LRG1
4 rough endoplasmic reticulum GO:0005791 9.61 SNCA PTGDS APP
5 platelet alpha granule lumen GO:0031093 9.58 TGFB1 SERPINA3 APP
6 growth cone GO:0030426 9.56 SNCA NEFL MAPT APP
7 neuronal cell body GO:0043025 9.43 TGFB1 SNPH SNCA SLC6A3 MAPT APOE
8 main axon GO:0044304 9.37 MAPT APP
9 axon GO:0030424 9.1 TGFB1 SNCA SLC6A3 NEFL MAPT APP

Biological processes related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.89 TGFB1 SNCA SLC6A3 AQP1
2 negative regulation of gene expression GO:0010629 9.87 TGFB1 MAPT APP APOE
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.69 TGFB1 SNCA APP
4 astrocyte activation GO:0048143 9.58 MAPT APP
5 water transport GO:0006833 9.58 AQP4 AQP1
6 axon development GO:0061564 9.56 NEFL MAPT
7 protein polymerization GO:0051258 9.55 NEFL MAPT
8 negative regulation of long-term synaptic potentiation GO:1900272 9.54 APP APOE
9 synapse organization GO:0050808 9.54 SNCA MAPT APP
10 supramolecular fiber organization GO:0097435 9.52 SNCA MAPT
11 amyloid fibril formation GO:1990000 9.49 MAPT APP
12 dopamine biosynthetic process GO:0042416 9.48 SNCA SLC6A3
13 multicellular organismal water homeostasis GO:0050891 9.46 AQP4 AQP1
14 neuron projection development GO:0031175 9.46 MAPT ERCC6 APP APOE
15 axonal transport of mitochondrion GO:0019896 9.43 NEFL MAPT
16 cellular water homeostasis GO:0009992 9.4 AQP4 AQP1
17 dopamine uptake involved in synaptic transmission GO:0051583 9.32 SNCA SLC6A3
18 positive regulation of amyloid fibril formation GO:1905908 9.26 APP APOE
19 microglial cell activation GO:0001774 9.13 SNCA MAPT APP
20 cellular response to copper ion GO:0071280 8.8 SNCA AQP1 APP

Molecular functions related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 TGFB1 SNCA NEFL MAPT AQP1 APP
2 phospholipase binding GO:0043274 9.4 SNCA NEFL
3 transforming growth factor beta receptor binding GO:0005160 9.37 TGFB1 LRG1
4 protein-containing complex binding GO:0044877 9.35 TGFB1 SLC6A3 NEFL ERCC6 APOE
5 water channel activity GO:0015250 9.32 AQP4 AQP1
6 lipoprotein particle binding GO:0071813 9.16 MAPT APOE
7 protein N-terminus binding GO:0047485 8.92 TGFB1 SNCA SLC6A3 ERCC6

Sources for Communicating Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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