MCID: CMM008
MIFTS: 43

Communicating Hydrocephalus

Categories: Fetal diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Communicating Hydrocephalus

MalaCards integrated aliases for Communicating Hydrocephalus:

Name: Communicating Hydrocephalus 12 29 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1573
ICD9CM 34 331.3
MeSH 43 D006849
NCIt 49 C34501
SNOMED-CT 67 59013007
ICD10 32 G91.0
UMLS 71 C0009451

Summaries for Communicating Hydrocephalus

MalaCards based summary : Communicating Hydrocephalus is related to normal pressure hydrocephalus and arachnoiditis. An important gene associated with Communicating Hydrocephalus is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Alzheimers Disease Pathway. The drug Mitogens has been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Communicating Hydrocephalus

Diseases in the Communicating Hydrocephalus family:

Hydrocephalus, Congenital Communicating, 1 Congenital Communicating Hydrocephalus

Diseases related to Communicating Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 normal pressure hydrocephalus 31.3 SFMBT1 SERPINA3 MIR4274 MAPT LRG1 AQP4
2 arachnoiditis 30.6 ASPRV1 AQP4
3 acoustic neuroma 30.6 TGFB1 AQP4 AQP1
4 obstructive hydrocephalus 30.4 ZIC3 AQP4 AQP1
5 apraxia 30.3 SLC6A3 MAPT APOE
6 intracranial hypertension, idiopathic 30.2 ASPRV1 AQP4 AQP1
7 binswanger's disease 30.1 MAPT APP APOE
8 cerebrovascular disease 30.1 SERPINA3 MAPT APP APOE
9 dementia 30.0 SLC6A3 SERPINA3 MAPT APP APOE
10 neuroma 29.8 TGFB1 SERPINA3 AQP4 AQP1
11 vascular dementia 29.7 SERPINA3 NEFL MAPT APP APOE
12 hydrocephalus 29.5 ZIC3 TGFB1 SLC6A3 SFMBT1 SERPINA3 MIR4274
13 parkinson disease, late-onset 29.1 SLC6A3 SERPINA3 NEFL MAPT APP APOE
14 congenital communicating hydrocephalus 12.5
15 hydrocephalus, endocardial fibroelastosis, and cataracts 11.9
16 hydrocephalus, congenital, 1 11.8
17 kozlowski brown hardwick syndrome 11.7
18 congenital hydrocephalus 11.5
19 thoracic dysplasia-hydrocephalus syndrome 11.5
20 hydrocephalus with cerebellar agenesis 11.5
21 cole-carpenter syndrome 11.5
22 mucopolysaccharidosis, type vi 11.2
23 coenurosis 11.2
24 posterior cortical atrophy 10.5 MAPT APOE
25 thyroid gland hurthle cell carcinoma 10.5 SERPINA3 AQP4
26 residual stage of open angle glaucoma 10.5 APP APOE
27 gerstmann syndrome 10.5 MAPT APOE
28 senile plaque formation 10.5 APP APOE
29 semantic dementia 10.4 MAPT APOE
30 autoimmune optic neuritis 10.4 AQP4 APP
31 anosognosia 10.4 APOE ADAMTS2
32 congenital nervous system abnormality 10.4 PRICKLE4 ERCC6 B3GNT2
33 cranial nerve disease 10.4 SERPINA3 ERCC6 AQP4
34 kohlschutter-tonz syndrome 10.3 MAPT APP APOE
35 subependymoma 10.3 AQP4 AQP1
36 brain injury 10.3 MAPT AQP4 APOE
37 basal ganglia calcification 10.3 MAPT ERCC6 APP
38 simultanagnosia 10.3 MAPT APOE ADAMTS2
39 visual agnosia 10.3 MAPT APOE ADAMTS2
40 intracranial berry aneurysm 10.3 SERPINA3 NEFL APOE
41 dysferlinopathy 10.3 AQP4 AQP1
42 physical disorder 10.3 PRICKLE4 ERCC6 B3GNT2
43 nominal aphasia 10.3 MAPT APOE ADAMTS2
44 degeneration of macula and posterior pole 10.3 SERPINA3 PRICKLE4 ERCC6 APOE
45 neuritis 10.3 MAPT AQP4 APOE
46 alexia 10.3 MAPT ASPRV1 APOE
47 autoimmune disease of central nervous system 10.3 SERPINA3 NEFL AQP4
48 alzheimer disease mitochondrial 10.3 MAPT APP
49 fatal familial insomnia 10.3 SERPINA3 MAPT ERCC6 APP
50 akinetic mutism 10.3 SLC6A3 MAPT

Comorbidity relations with Communicating Hydrocephalus via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Decubitus Ulcer Deficiency Anemia
Hypertension, Essential Hypothyroidism
Obstructive Hydrocephalus Parkinson Disease, Late-Onset
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Communicating Hydrocephalus:



Diseases related to Communicating Hydrocephalus

Symptoms & Phenotypes for Communicating Hydrocephalus

MGI Mouse Phenotypes related to Communicating Hydrocephalus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 APOE APP AQP1 AQP4 B3GNT2 ERCC6
2 nervous system MP:0003631 9.93 APOE APP AQP1 AQP4 B3GNT2 ERCC6
3 respiratory system MP:0005388 9.5 ADAMTS2 APOE AQP1 AQP4 B3GNT2 TGFB1
4 taste/olfaction MP:0005394 8.92 APOE B3GNT2 MAPT SLC6A3

Drugs & Therapeutics for Communicating Hydrocephalus

Drugs for Communicating Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Lumbar Drainage for Communicating Hydrocephalus After Intraventricular Hemorrhage: a Randomised, Controlled Trial(LUCAS-IVH: LUmbar CAtheter for Severe IntraVentricular Hemorrhage) Completed NCT01041950 Phase 2, Phase 3
2 A Randomized Controlled Trial of Endoscopic Third Ventriculostomy Versus Ventricular Shunt for Children With Communicating Hydrocephalus Completed NCT01801267
3 Novel Infusion Method for Describing CSF Dynamics Completed NCT01319136
4 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia ("POTS" -- Postural Orthostatic Tachycardia Syndrome)Later in Life -- a Retrospective Analysis Completed NCT01367977
5 Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus Completed NCT00600795
6 Laparoscopically Assisted Ventriculoperitoneal Shunt Placement: A Prospective, Randomized Two-arm Study Completed NCT01739179
7 Alterations in Cerebral Perfusion, Oxygenation, Electrical Activity, and Markers of Cerebral Damage Associated With Cerebro-spinal Fluid Reservior Aspiration in Neonates With Post Hemorrhagic Hydrocephalus Completed NCT00747682
8 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138
9 Assessment of Cerebrospinal Fluid Flow Related Disorders Using a Phase-contrast Magnetic Resonance Imaging Technique. Recruiting NCT03656016
10 Study of Endoscopic Choroid Plexus Cauterization for Adult Patients With Hydrocephalus and Risk Factors for Perioperative Complications Following Shunt Surgery. Recruiting NCT02900222
11 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633
12 Endoscopic Third Ventriculostomy (ETV) Versus Ventriculoperitoneal Shunting (VPS) for the Surgical Management of Normal Pressure Hydrocephalus Terminated NCT00946127
13 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life -- a Retrospective Analysis Withdrawn NCT01377805

Search NIH Clinical Center for Communicating Hydrocephalus

Genetic Tests for Communicating Hydrocephalus

Genetic tests related to Communicating Hydrocephalus:

# Genetic test Affiliating Genes
1 Communicating Hydrocephalus 29

Anatomical Context for Communicating Hydrocephalus

MalaCards organs/tissues related to Communicating Hydrocephalus:

40
Brain, Testes, Bone, Spinal Cord, Heart, B Cells, Pineal

Publications for Communicating Hydrocephalus

Articles related to Communicating Hydrocephalus:

(show top 50) (show all 1110)
# Title Authors PMID Year
1
Inflammatory cytokine cascade released by leukocytes in cerebrospinal fluid after subarachnoid hemorrhage. 54 61
11680512 2001
2
Transforming growth factor-beta1 in the cerebrospinal fluid of patients with subarachnoid hemorrhage: titers derived from exogenous and endogenous sources. 54 61
11176281 2001
3
Study of cerebrospinal fluid flow dynamics in TGF-beta 1 induced chronic hydrocephalic mice. 54 61
10763513 2000
4
Ultramicroscopic structures of the leptomeninx of mice with communicating hydrocephalus induced by human recombinant transforming growth factor-beta 1. 54 61
10063355 1998
5
Elevation of transforming growth factor-beta 1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. 54 61
8023355 1994
6
Induction of communicating hydrocephalus in mice by intrathecal injection of human recombinant transforming growth factor-beta 1. 54 61
8120136 1994
7
Diffuse leptomeningeal glioneuronal tumour (DLGNT) with hydrocephalus as an initial symptom: a case-based update. 61
31897629 2020
8
Neurosarcoidosis presenting with isolated intracranial mass lesion and communicating hydrocephalus. 61
31882303 2019
9
Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus. 61
31865917 2019
10
Endoscopic third ventriculostomy in children with third ventricular pressure gradient and open ventricular outlets on MRI. 61
31654263 2019
11
Efficacy and Safety of Lumboperitoneal Shunt in the Treatment of All-Cause Communicating Hydrocephalus: Analysis of Risk Factors of Shunt Failure. 61
31226460 2019
12
Intrathecal nusinersen treatment after ventriculo-peritoneal shunt placement: A case report focusing on the neurofilament light chain in cerebrospinal fluid. 61
31889567 2019
13
Communicating hydrocephalus after radiosurgery for vestibular schwannomas: does technique matter? A systematic review and meta-analysis. 61
31621039 2019
14
Isolated leptomeningeal carcinomatosis and possible fungal meningitis as late sequelae of oesophageal adenocarcinoma. 61
31678919 2019
15
Hydrocephalus Secondary to Intradural Extramedullary Malignant Melanoma of Spinal Cord. 61
31302270 2019
16
[Extra-ventricular drainage for the treatment of pneumococcal meningitis and hydrocephalus: a case report]. 61
31474646 2019
17
Myxopapillary ependymoma of cauda equina presented with communicating hydrocephalus and papilloedema: A case report. 61
31424046 2019
18
Aqueductal Cerebrospinal Fluid Stroke Volume Flow in a Rodent Model of Chronic Communicating Hydrocephalus: Establishing a Homogeneous Study Population for Cerebrospinal Fluid Dynamics Exploration. 61
31121363 2019
19
Relationship between intracranial pressure and phase-contrast cine MRI-derived measures of cerebrospinal fluid parameters in communicating hydrocephalus. 61
31559170 2019
20
The effect of ventricular volume increase in the amplitude of intracranial pressure. 61
30931613 2019
21
Spinal paraganglioma presenting as normal pressure hydrocephalus: a rare occurrence. 61
31317776 2019
22
Endoscopic Third Ventriculostomy in Cases of Ventriculoperitoneal Shunt Malfunction: Does Shunt Duration Play a Role? 61
30954740 2019
23
Lumboperitoneal and Ventriculoperitoneal Shunt Surgery for Posthemorrhagic Communicating Hydrocephalus: A Comparison. 61
30947009 2019
24
AQP1 Overexpression in the CSF of Obstructive Hydrocephalus and Inversion of Its Polarity in the Choroid Plexus of a Chiari Malformation Type II Case. 61
31039249 2019
25
Hydrocephalus due to a Cavernoma-Like Lesion of an Obliterated Cerebral Arteriovenous Malformation Treated by Embolization and Radiosurgery. 61
30885872 2019
26
Anatomical characterization of the inferior petrosal sinus and adjacent cerebellopontine angle cistern for development of an endovascular transdural cerebrospinal fluid shunt. 61
30626626 2019
27
Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension. 61
30560499 2019
28
Fetoscopic spina bifida repair. 61
30486637 2019
29
Hydrocephalus after Gamma Knife Radiosurgery for Schwannoma. 61
31143267 2019
30
Choroidal artery embolization in the management of cerebrospinal fluid overproduction: case report and review of the literature. 61
30901750 2019
31
Leptomeningeal Carcinomatosis as the Initial Manifestation of Metastatic Disease diagnosed in Postmortem Examination: A Case Series. 61
30924918 2019
32
Surgical Management of Isolated Fourth Ventricular Hydrocephalus Associated with Injury to the Guillain-Mollaret Triangle. 61
30368016 2019
33
Association of Severe Hydrocephalus With Congenital Zika Syndrome. 61
30452526 2019
34
Intraventricular Pressure in Non-communicating Hydrocephalus Patients Before Endoscopic Third Ventriculostomy. 61
31934636 2019
35
Intraoperative measurement of intraventricular pressure in dogs with communicating internal hydrocephalus. 61
31560704 2019
36
The value of CSF flow studies in the management of CSF disorders in children: a pictorial review. 61
30689061 2019
37
Primary leptomeningeal melanocytic tumors of the spine: report of two cases and review of the literature. 61
30660881 2019
38
Bilateral skull fracture with massive epidural hematoma secondary to pin-type head fixation in a pediatric patient: Case report and review of the literature. 61
31445499 2019
39
Relationship between the location of the ventricular catheter tip and the ventriculoperitoneal shunt malfunction. 61
30366188 2018
40
Shunt Surgery for Neurocutaneous Melanosis with Hydrocephalus: Case Report and Review of the Literature. 61
30205217 2018
41
Ventricular Volume Dynamics During the Development of Adult Chronic Communicating Hydrocephalus in a Rodent Model. 61
30217783 2018
42
Patterns of Hydrocephalus in Rural Haiti: A Computed Tomography-Based Study. 61
30096500 2018
43
Cerebral and occipito-atlanto-axial involvement in mucopolysaccharidosis patients: clinical, radiological, and neurosurgical features. 61
30442179 2018
44
Ventriculoperitoneal shunt malfunction: analysis of abdominal causes. 61
30563600 2018
45
Case of Lumbar Schwannoma Presenting with Isolated Signs and Symptoms of Intracranial Hypertension. 61
30096499 2018
46
Disproportionately Large Communicating Fourth Ventricle: Pearls for Diagnosis and Management. 61
30648079 2018
47
Outcomes following cerebrospinal fluid shunting in high-grade glioma patients. 61
29271709 2018
48
The programmable shunt-system Codman Medos Hakim: A clinical observation study and review of literature. 61
30142621 2018
49
The 50 most cited publications in endoscopic third ventriculostomy: a bibliometric analysis. 61
30497225 2018
50
A Randomized Study Comparing Endoscopic Third Ventriculostomy versus Ventriculoperitoneal Shunt in the Management of Hydrocephalus Due to Tuberculous Meningitis. 61
30459883 2018

Variations for Communicating Hydrocephalus

Expression for Communicating Hydrocephalus

Search GEO for disease gene expression data for Communicating Hydrocephalus.

Pathways for Communicating Hydrocephalus

Pathways related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 ZIC3 TGFB1 SFMBT1 APP
2 10.45 MAPT APP APOE

GO Terms for Communicating Hydrocephalus

Cellular components related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.55 SNPH SLC6A3 NEFL MAPT APP
2 platelet alpha granule lumen GO:0031093 9.5 TGFB1 SERPINA3 APP
3 neuronal cell body GO:0043025 9.35 TGFB1 SNPH SLC6A3 MAPT APOE
4 main axon GO:0044304 9.26 MAPT APP
5 axon GO:0030424 9.02 TGFB1 SLC6A3 NEFL MAPT APP

Biological processes related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.73 TGFB1 MAPT APP APOE
2 astrocyte activation GO:0048143 9.49 MAPT APP
3 water transport GO:0006833 9.48 AQP4 AQP1
4 axon development GO:0061564 9.46 NEFL MAPT
5 negative regulation of long-term synaptic potentiation GO:1900272 9.4 APP APOE
6 protein polymerization GO:0051258 9.37 NEFL MAPT
7 amyloid fibril formation GO:1990000 9.32 MAPT APP
8 multicellular organismal water homeostasis GO:0050891 9.26 AQP4 AQP1
9 axonal transport of mitochondrion GO:0019896 9.16 NEFL MAPT
10 positive regulation of amyloid fibril formation GO:1905908 8.96 APP APOE
11 neuron projection development GO:0031175 8.92 MAPT ERCC6 APP APOE

Molecular functions related to Communicating Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.33 TGFB1 SLC6A3 ERCC6
2 water channel activity GO:0015250 8.96 AQP4 AQP1
3 lipoprotein particle binding GO:0071813 8.62 MAPT APOE

Sources for Communicating Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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