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MCID: CMP008
MIFTS: 48

Compartment Syndrome

Categories: Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Compartment Syndrome

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MalaCards integrated aliases for Compartment Syndrome:

Name: Compartment Syndrome 12 74 52 15
Compartment Syndromes 54 43 71
Compartmental Syndrome 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:682
ICD9CM 34 958.90
MeSH 43 D003161
NCIt 49 C118422
SNOMED-CT 67 45781009
ICD10 32 T79.A0
UMLS 71 C0009492
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Summaries for Compartment Syndrome

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MalaCards based summary : Compartment Syndrome, also known as compartment syndromes, is related to anterior compartment syndrome and encephalopathy, progressive, early-onset, with episodic rhabdomyolysis, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Compartment Syndrome is MB (Myoglobin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Compartment syndrome is a condition in which increased pressure within one of the body's anatomical... more...

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Related Diseases for Compartment Syndrome

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Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 768)
# Related Disease Score Top Affiliating Genes
1 anterior compartment syndrome 34.7 PIK3C2A MB HECTD4
2 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 31.8 PIK3C2A MB CHKB
3 gas gangrene 31.1 PIK3C2A MB CRP
4 acute kidney failure 30.8 PIK3C2A MB GPT F2 ALB
5 ileus 30.8 TNF F2 CRP
6 acute pancreatitis 30.7 TNF GPT CRP ALB
7 peritonitis 30.7 TNF F2 CRP ALB
8 myoglobinuria 30.7 PIK3C2A MB GPT CHKB
9 myositis 30.7 TNF SLC17A5 PIK3C2A MB CHKB
10 pyomyositis 30.6 PIK3C2A MB CRP
11 acute kidney tubular necrosis 30.5 PIK3C2A MB ALB
12 thrombophilia due to thrombin defect 30.5 SERPINC1 F8 F3 F2
13 hemophilia a 30.5 F8 F7 F3
14 volkmann contracture 30.5 SERPINC1 F3 F2 EVC2
15 acquired hemophilia 30.3 F8 F3
16 tendinitis 30.3 TNF HECTD4 CRP
17 factor viii deficiency 30.3 F8 F7 F3 F2
18 acquired hemophilia a 30.3 F8 F3
19 toxic megacolon 30.3 TNF CRP ALB
20 malignant hyperthermia 30.3 PIK3C2A MB GPT CHKB
21 hepatorenal syndrome 30.2 GPT F2 ALB
22 chickenpox 30.2 TNF CRP ALB
23 acute liver failure 30.2 SLC17A5 GPT F2 ALB
24 intestinal obstruction 30.2 GPT CRP ALB
25 toxic shock syndrome 30.2 TNF SERPINC1 F3 CRP
26 anuria 30.1 PIK3C2A MB F3 F2 CRP ALB
27 cholecystitis 30.1 GPT F2 ALB
28 paralytic ileus 30.1 GPT F2 CRP ALB
29 tenosynovitis 30.1 TNF HECTD4 CRP
30 mononeuropathy 30.1 TNF HECTD4 CRP
31 infective endocarditis 30.1 TNF F2 CRP
32 von willebrand's disease 30.1 F8 F3 F2
33 appendicitis 30.1 TNF CRP ALB
34 neuroleptic malignant syndrome 30.1 PIK3C2A MB GPT CHKB
35 peroneal nerve paralysis 30.0 ZDHHC2 MB HECTD4
36 femoral neuropathy 30.0 F3 F2
37 peptic ulcer perforation 30.0 CRP ALB
38 hemorrhoid 29.9 F2 CRP ALB
39 eclampsia 29.9 TNF SERPINC1 F2 ALB
40 necrotizing fasciitis 29.9 PLG F3 CRP ALB
41 intestinal perforation 29.9 GPT CRP ALB
42 diverticulitis 29.9 TNF CRP ALB
43 volvulus of midgut 29.9 GPT F2 CRP ALB
44 epidural abscess 29.9 F3 CRP ALB
45 calcific tendinitis 29.9 HECTD4 CRP
46 sickle cell anemia 29.8 TNF F2 ALB
47 leptin deficiency or dysfunction 29.8 TNF GPT CRP ALB
48 peripheral vascular disease 29.8 SERPINC1 F3 F2 CRP ALB
49 intermittent claudication 29.8 SERPINC1 F2 CRP ALB
50 intracranial hypertension 29.8 TNF SERPINC1 F3 F2 ALB

Graphical network of the top 20 diseases related to Compartment Syndrome:



Diseases related to Compartment Syndrome
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Symptoms & Phenotypes for Compartment Syndrome

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UMLS symptoms related to Compartment Syndrome:


muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

MGI Mouse Phenotypes related to Compartment Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ABRA ALB CRP F2 F3 F7
2 homeostasis/metabolism MP:0005376 9.83 ABRA ALB CHKB CRP F2 F3
3 mortality/aging MP:0010768 9.44 ALB EVC2 F2 F3 F7 F8
Sources

Drugs & Therapeutics for Compartment Syndrome

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Drugs for Compartment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4 9005-49-6
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Verapamil Approved Phase 4 52-53-9 2520
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
6
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
7 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
8
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
9
Choline Approved, Nutraceutical Phase 4 62-49-7 305
10 Hypnotics and Sedatives Phase 4
11 Anesthetics, General Phase 4
12 Anesthetics, Intravenous Phase 4
13 Plasma Substitutes Phase 4
14 Blood Substitutes Phase 4
15 Hydroxyethyl Starch Derivatives Phase 4
16 Heparin, Low-Molecular-Weight Phase 4
17 calcium heparin Phase 4
18 Anti-Arrhythmia Agents Phase 4
19 Fibrinolytic Agents Phase 4
20 Vasodilator Agents Phase 4
21 Calcium, Dietary Phase 4
22 calcium channel blockers Phase 4
23 Hormones Phase 4
24 Nootropic Agents Phase 4
25 Cytidine Diphosphate Choline Phase 4
26 Anticoagulants Phase 4
27 Antitubercular Agents Phase 4
28 Anti-Bacterial Agents Phase 4
29 Antibiotics, Antitubercular Phase 4
30 Amoxicillin-Potassium Clavulanate Combination Phase 4
31 beta-Lactamase Inhibitors Phase 4
32 Anti-Infective Agents Phase 4
33 Anesthetics, Local Phase 4
34 Anesthetics Phase 4
35 Central Nervous System Depressants Phase 4
36 Antigen-Antibody Complex Phase 4
37
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
38
Tranexamic Acid Approved Phase 3 1197-18-8 5526
39
Argatroban Approved, Investigational Phase 3 74863-84-6 152951
40
Thrombin Approved, Investigational Phase 3
41 Neurotransmitter Agents Phase 2, Phase 3
42 Acetylcholine Release Inhibitors Phase 2, Phase 3
43 Botulinum Toxins Phase 2, Phase 3
44 Cholinergic Agents Phase 2, Phase 3
45 Hemostatics Phase 3
46 Coagulants Phase 3
47
protease inhibitors Phase 3
48 HIV Protease Inhibitors Phase 3
49 Antifibrinolytic Agents Phase 3
50 Antithrombins Phase 3

Interventional clinical trials:

(show top 50) (show all 136)
# Name Status NCT ID Phase Drugs
1 Hypertonic Saline Resuscitation for Early Closure of Open Abdomen in Trauma Patients Unknown status NCT02542241 Phase 4 Sodium Chloride [3%];Sodium Chloride [0.9%]
2 Prospective, Interventional Multicentre Study on the Effect of Deepening of Sedation on Intra-abdominal Pressure Unknown status NCT02944292 Phase 4 Propofol
3 Assessment of Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava by Emergency Ultrasonography Before and After Fluid Therapy Completed NCT01553422 Phase 4
4 Colloids in Severe Trauma: A Multi-Center Pilot Study of "Crystalloid Only" or "Crystalloid + Colloid" Volume Resuscitation in Trauma Patients (CIST) Completed NCT00890383 Phase 4 tetrastarch (Voluven)
5 Comparison of VERapamil vs. Heparin Therapy on Procedural sUccess During Transradial Coronary Procedures (VERMUT Study) Completed NCT02454491 Phase 4 Heparin;Verapamil
6 A Prospective, Controlled Evaluation of ABRA Abdominal Wall Closure System in Combination With V.A.C. Therapy Compared to V.A.C. Alone in the Management of Open Abdomen Completed NCT00754156 Phase 4
7 The Efficacy of Demineralized Bone Matrix and Autogenous Bone Graft in Accelerated Fracture Healing in Closed Tibia Fracture Completed NCT00299052 Phase 4
8 Clinically-Important Venous Thromboembolism Following Lower Extremity Fractures: Epidemiology & Prevention Completed NCT00187408 Phase 4 Low Molecular Weight Heparin (dalteparin)
9 Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Completed NCT01531543 Phase 4
10 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
11 Routine vs. Clinically-Directed Antibiotic Treatment in Snake Bite With Local Envenomation: a Randomised Controlled Trial Recruiting NCT02570347 Phase 4 Co-amoxiclav
12 Interventional Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in High-risk Patients With Atrial Fibrillation (PRAGUE-17 Study) Recruiting NCT02426944 Phase 4 NOAC
13 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
14 Efficacy and Safety of OctaplasLG Administration vs. Crystalloids (Standard) in Patients With Septic Shock - a Randomized, Controlled, Open-label Investigator-initiated Pilot Trial Terminated NCT02875236 Phase 4 OctaplasLG®;Ringer-acetat
15 A Randomized, Double-blind Controlled Trial of Bupivacaine Extended-release Liposome Injection for Postsurgical Analgesia in Patients Undergoing Open-reduction Internal Fixation of the Distal Radius Terminated NCT02515851 Phase 4 Exparel;Placebo
16 Correlation Between Muscle Oxygenation and Skin Pigmentation Withdrawn NCT00747162 Phase 4
17 Temporal Trend Analysis of Nurse's Knowledge and Practice Before and After Implementing an Educational Program Regarding Abdominal Compartment Syndrome Unknown status NCT02639013 Phase 3
18 The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function in Critically Ill Adults With Intra-abdominal Hypertension and Acute Kidney Injury Unknown status NCT01077895 Phase 3
19 Study of Primary Fascial Closure Rate in Patients With Open Abdomen Treated With Abthera Versus Barker Technique Unknown status NCT02952976 Phase 3
20 Percutaneous Catheter Decompression in the Treatment of Elevated Intra-abdominal Pressure Completed NCT01230255 Phase 3
21 Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury Completed NCT01120730 Phase 3 fluid resuscitation;Fluid resuscitation
22 Comparison of Botulinum Toxin to Fasciotomy in Treatment of Chronic Exertional Compartment Syndrome Recruiting NCT03339921 Phase 2, Phase 3 Botulinum toxin injections for chronic compartment syndrome
23 The Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Recruiting NCT02125890 Phase 3 Tranexamic Acid
24 An Open-Label, Randomised, Active Controlled, Multi-Centre Phase 3 Study to Evaluate the Safety and Efficacy of Danaparoid vs Argatroban in Treatment of Subjects With Acute HIT (HITSOVA Study) Recruiting NCT03809481 Phase 3 Danaparoid Sodium;Argatroban
25 Phase III Study of Usefulness of Near Infrared Spectroscopy to Optimize Tissues Perfusion and Oxygenation in Severe Sepsis Terminated NCT00167596 Phase 2, Phase 3
26 Intravitreal Bevacizumab for Treatment of the Second Eye With Non-Arteritic Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
27 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock Completed NCT01611935 Phase 2 Vasopressin
28 OnabotulinumtoxinA (Botox) Effect on Pain and Return to Sport in Chronic Exertional Compartment Syndrome of the Anterior Leg: A Pilot Study Recruiting NCT03922139 Phase 1, Phase 2 OnabotulinumtoxinA Injection
29 Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease Recruiting NCT03791775 Phase 2 Polidocanol foam (Atossisclerol® 3%)
30 Prospective Placebo-Controlled Double-Blinded Trial for High-Dose Vitamin C Administration During the Acute Resuscitative Phase of Severe Thermal Injuries Withdrawn NCT01587261 Phase 2 Vitamin C;Placebo
31 The Curative Effect and Security of Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension Unknown status NCT02543658 Phase 1 Neostigmine;The traditional treatment
32 Phase I, Arteriocyte Magellan MAR01 Therapy - Compartment Syndrome and Battlefield Trauma Study Protocol Completed NCT01837264 Phase 1
33 In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome. Completed NCT01452425 Phase 1
34 Management of Compartment Syndrome With Ultrafiltration Completed NCT00022815 Phase 1
35 A Prospective, Non-Randomized, Open-Label Study on the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
36 Autologous Bone Marrow Mononuclear Cell Administration for Lower Extremity Compartment Syndrome Injury Not yet recruiting NCT03880656 Phase 1
37 Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers Not yet recruiting NCT04113954 Phase 1 Mepivacaine Injection;Normal saline Injection
38 Oral Rehydration Therapy in Burn Patients Phase 1 Terminated NCT02124265 Phase 1 CeraLyte 90
39 Effects of Perioperative Patient Education Regarding Compartment Syndrome on Post-operative Opioid Consumption Unknown status NCT03359031
40 Abdominal Compartment Syndrome and Ruptured Aortic Aneurysm : Validation of a Predictive Test Unknown status NCT02859662
41 Decompressive Laparotomy With Temporary Abdominal Closure Versus Percutaneous Puncture With Placement of Abdominal Catheter in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis:Multicenter, Randomised, Controlled Study Unknown status NCT00793715
42 Near Infrared Spectroscopy for Determination of Tissue Oxygenation in Patients Undergoing Robotic Assisted Laparoscopic Surgery in the Trendelenburg Position - A Feasibility Study Unknown status NCT02829242
43 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome Unknown status NCT01171638
44 Abdominal Compartment Syndrome : Diagnostic and Prognostic Value of CT Findings - a Prospective Study Unknown status NCT02814734
45 Double Blinded Study for the Reduction of the Incidence of Fasciotomy Unknown status NCT01879696
46 Randomized Clinical Trial of Tissue Ultrafiltration and Pressure Monitoring for the Diagnosis and Prevention of Compartment Syndrome Unknown status NCT00681616
47 The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension and Abdominal Compartment Syndrome. Unknown status NCT02229695
48 The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Mechanically Ventilated Critically Ill Patients With Secondary Intra-abdominal Hypertension Unknown status NCT01072071 furosemide
49 Fluid Resuscitation Goal in Early Stage of Severe Acute Pancreatitis Unknown status NCT01974466
50 Effects of Early Stage Mini-invasive Abdominal Drainage on Complications and Prognosis of SAP Unknown status NCT02002793

Search NIH Clinical Center for Compartment Syndrome

Cochrane evidence based reviews: compartment syndromes

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Genetic Tests for Compartment Syndrome

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Anatomical Context for Compartment Syndrome

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MalaCards organs/tissues related to Compartment Syndrome:

40
Liver, Bone, Kidney, Heart, Skin, Testes, Skeletal Muscle
Sources

Publications for Compartment Syndrome

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Articles related to Compartment Syndrome:

(show top 50) (show all 6616)
# Title Authors PMID Year
1
Do creatine kinase (CK) levels influence the diagnosis or outcome in patients with compartment syndrome? 54 61
16374979 2005
2
[Neuropathy of common sciatic nerve secondary to compartment syndrome as a complication after bariatric surgery]. 54 61
15726478 2005
3
Acquired anti-FVIII inhibitors in children. 54 61
11886462 2002
4
[Pathogenesis of pulmonary thrombosis in Duchenne muscular dystrophy; a consideration from changes in serum CK and LDH levels]. 54 61
10825803 2000
5
Exertional collapse and sudden death associated with sickle cell trait. 54 61
8677839 1996
6
[Postoperative bilateral compartment syndrome resulting from prolonged urological surgery in lithotomy position. Serum creatine kinase activity (CK) as a warning signal in sedated, artificially respirated patients]. 54 61
7695079 1995
7
Flexible intramedullary nailing in the treatment of forearm fractures in children and adolescents, a systematic review. 61
32025135 2020
8
A human cadaveric model for effective instruction of lateral canthotomy and cantholysis. 61
31106640 2020
9
Do Patient-specific or Fracture-specific Factors Predict the Development of Acute Compartment Syndrome After Pediatric Tibial Shaft Fractures? 61
31157755 2020
10
Reperfusion Injury with Compartment Syndrome Following Systemic Thrombolysis for Cardiac Catheterization-Related Arterial Thrombosis in an Infant. 61
31984163 2020
11
Intra-abdominal Hypertension and the Open Abdomen: Nursing Guidelines From the Abdominal Compartment Society. 61
32006038 2020
12
Optimizing Health, Wellness, and Performance of the Tactical Athlete. 61
32028351 2020
13
Entero-atmospheric fistula migration: a new management alternative for complex septic open abdomen. 61
32024350 2020
14
Henry Versus Thompson Approach for Fixation of Proximal Third Radial Shaft Fractures: A Multicenter Study. 61
31809416 2020
15
Bench Validation of a Handcrafted Prototype Catheter for Intra-gastric Pressure Monitoring. 61
32016541 2020
16
The Reverse Oblique Supracondylar Humerus Fracture: Description of a Novel Fracture Pattern. 61
31022014 2020
17
Right Colectomy with Absorbable Mesh Repair as a Salvage Solution for the Management of Giant Incisional Hernia with Loss of Domain: Results of a Bicentric Study. 61
32016544 2020
18
Sudden hemodynamic collapse after prone positioning on a Jackson spinal table for spinal surgery. 61
30590915 2020
19
Management of Acute Compartment Syndrome. 61
31977609 2020
20
Crimean-Congo haemorrhagic fever presenting with acute compartment syndrome of the extremities (think beyond normal infections). 61
32033997 2020
21
Risk Management and Avoiding Legal Pitfalls in the Emergency Treatment of High-Risk Orthopedic Injuries. 61
31757250 2020
22
Historic cohort: outcome of chronic exertional compartment syndrome-suspected patients. 61
32019808 2020
23
Predicting factors of muscle necrosis in acute compartment syndrome of the lower extremity. 61
31767373 2020
24
Risk factors for death and amputation in acute leg compartment syndrome. 61
31560102 2020
25
Non-invasive measurement of muscle compartment elasticity in lower limbs to determine acute compartment syndrome: Clinical results with pressure related ultrasound. 61
31784057 2020
26
Chronic Lower Leg Pain in Athletes: Overview of Presentation and Management. 61
32015745 2020
27
The Cushing reflex and the vasopressin-mediated hemodynamic response to increased intracranial pressure during acute elevations in intraabdominal pressure. 61
31813477 2020
28
Initiation of Extracorporeal Membrane Oxygenation in the Cardiac Catheterization Laboratory: The Mayo Clinic Experience. 61
31841997 2020
29
Knee dislocation and associated injuries: an analysis of the American College of Surgeons National Trauma Data Bank. 61
31559462 2020
30
Outcomes of surgical treatment of the tibial tuberosity fractures in skeletally immature patients: an update. 61
31989257 2020
31
Anatomy of foot Compartments: a systematic review. 61
31978573 2020
32
Transinguinal preperitoneal repair of giant inguinoscrotal hernias using Kugel mesh. 61
32009003 2020
33
Endoscopic Resection of Peroneus Quartus. 61
32021771 2020
34
Evaluation and management of intraabdominal hypertension. 61
32004192 2020
35
A Novel Technique for a Successful Closed Reduction of a Bosworth Fracture-Dislocation of the Ankle. 61
31966945 2020
36
Early Initiation of Renal Replacement Therapy Among Burned Patients With Acute Kidney Injury. 61
31977529 2020
37
Open Reduction of Neglected Supracondylar Humeral Fractures With Callus Formation in Children. 61
32011548 2020
38
Outcomes and Predictors of Popliteal Artery Injury in Pediatric Trauma. 61
31978483 2020
39
An atypical presentation of leiomyosarcoma causing extremity compartment syndrome of the crural region in a Dutch Warmblood mare: a case report. 61
31940682 2020
40
Compartment syndrome: Neuromuscular complications and electrodiagnosis. 61
31944307 2020
41
Compartment syndrome after distal biceps brachii tendon rupture in an athlete. 61
31994610 2020
42
Chronic exertional compartment syndrome as a cause of anterolateral leg pain. 61
30980096 2020
43
Deep posterior chronic exertional compartment syndrome as a cause of leg pain. 61
31098648 2020
44
The rise of non-traumatic extremity compartment syndrome in light of the opioid epidemic. 61
32005410 2020
45
Acute compartment syndrome of the forearm associated with transradial coronary intervention. 61
31964211 2020
46
Abdominal compartment syndrome: Often overlooked conditions in medical intensive care units. 61
31988588 2020
47
Utilization of Fluorescence Microangiography in Pediatric Acute Compartment Syndrome: A Case Report. 61
31757750 2020
48
Minimally invasive fasciotomy using a lighted retractor in the treatment of chronic exertional compartment syndrome. 61
31876241 2020
49
Guidewire perforation and compartment syndrome after lower extremity angioplasty. 61
31414968 2020
50
Pediatric acute compartment syndrome: a systematic review and meta-analysis. 61
30688754 2020
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Variations for Compartment Syndrome

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Expression for Compartment Syndrome

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Search GEO for disease gene expression data for Compartment Syndrome.
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Pathways for Compartment Syndrome

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Pathways related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.88 SERPINC1 PLG F8 F7 F3 F2
2
Collagen chain trimerization 65
Show member pathways
 12.45 SERPINC1 F8 F7 F3 F2
3
Folate Metabolism 1
Show member pathways
 11.97 TNF PLG F7 F2 CRP ALB
4
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.63 SERPINC1 PLG F8 F7 F3 F2
5
Complement and coagulation cascades 1 36
11.26 SERPINC1 PLG F8 F7 F3 F2
Sources

GO Terms for Compartment Syndrome

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Cellular components related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.06 TNF SERPINC1 PLG F8 F7 F3
2 collagen-containing extracellular matrix GO:0062023 9.72 SERPINC1 PLG F7 F3 F2
3 blood microparticle GO:0072562 9.56 SERPINC1 PLG F2 ALB
4 endoplasmic reticulum lumen GO:0005788 9.55 SERPINC1 F8 F7 F2 ALB
5 platelet alpha granule lumen GO:0031093 9.54 PLG F8 ALB
6 extracellular space GO:0005615 9.32 TNF SERPINC1 PLG GPT F8 F7
7 serine-type peptidase complex GO:1905286 8.96 F7 F3

Biological processes related to Compartment Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.71 F8 F7 F2 ERGIC1
2 cellular protein metabolic process GO:0044267 9.55 ZDHHC2 SERPINC1 PLG F2 ALB
3 positive regulation of positive chemotaxis GO:0050927 9.49 F7 F3
4 regulation of blood coagulation GO:0030193 9.48 SERPINC1 F2
5 negative regulation of fibrinolysis GO:0051918 9.46 PLG F2
6 negative regulation of lipid storage GO:0010888 9.43 TNF CRP
7 acute-phase response GO:0006953 9.43 F8 F2 CRP
8 blood coagulation GO:0007596 9.43 SERPINC1 PLG F8 F7 F3 F2
9 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.37 F7 F3
10 blood coagulation, extrinsic pathway GO:0007598 9.32 F7 F3
11 hemostasis GO:0007599 9.1 SERPINC1 PLG F8 F7 F3 F2

Molecular functions related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.92 PLG F7 F3 F2
Sources

Sources for Compartment Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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