Compartment Syndrome

Categories: Blood diseases, Cardiovascular diseases, Mental diseases, Muscle diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Compartment Syndrome

MalaCards integrated aliases for Compartment Syndrome:

Name: Compartment Syndrome 11 19 75 14
Compartment Syndromes 53 43 71
Compartmental Syndrome 11


External Ids:

Disease Ontology 11 DOID:682
ICD9CM 34 958.90
MeSH 43 D003161
NCIt 49 C118422
SNOMED-CT 68 212379008
UMLS 71 C0009492

Summaries for Compartment Syndrome

GARD: 19 Conditions in which increased pressure within a limited space compromises the BLOOD CIRCULATION and function of tissue within that space. Some of the causes of increased pressure are TRAUMA, tight dressings, HEMORRHAGE, and exercise. Sequelae include nerve compression (NERVE COMPRESSION SYNDROMES); PARALYSIS; and ISCHEMIC CONTRACTURE.

MalaCards based summary: Compartment Syndrome, also known as compartment syndromes, is related to anterior compartment syndrome and hemophilia, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Compartment Syndrome is MB (Myoglobin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Acetylcholine and Kava have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone marrow and liver, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: 75 Compartment syndrome is a condition in which increased pressure within one of the body's anatomical... more...

Related Diseases for Compartment Syndrome

Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1213)
# Related Disease Score Top Affiliating Genes
1 anterior compartment syndrome 33.0 PIK3C2A MB
2 hemophilia 30.9 F9 F8 F2
3 myoglobinuria 30.9 PIK3C2A MB GPT
4 pyomyositis 30.6 PIK3C2A MB CRP
5 thrombophilia due to thrombin defect 30.6 SERPINC1 F9 F8 F3 F2
6 osteomyelitis 30.6 TNF IL6 CRP
7 ileus 30.5 TNF IL6 CRP
8 hemophilia a 30.5 F9 F8 F7 F3 F2
9 gastric dilatation 30.4 CRP ALB
10 aortic aneurysm 30.4 TNF IL6 F3 F2 CRP ALB
11 myositis 30.4 TNF PIK3C2A MB IL6 CHKB
12 nonarteritic anterior ischemic optic neuropathy 30.3 SERPINC1 F2 CRP
13 metabolic acidosis 30.3 IL6 GPT F2 ALB
14 acute kidney failure 30.2 PIK3C2A MB LCN2 IL6 GPT F2
15 enterocolitis 30.2 TNF IL6 CRP
16 chronic intestinal vascular insufficiency 30.2 CRP ALB
17 spontaneous tension pneumothorax 30.2 GPT CRP
18 malignant hyperthermia 30.2 PIK3C2A MB IL6 GPT
19 limb ischemia 30.1 SERPINC1 PLG IL6 F3 CRP ALB
20 toxic shock syndrome 30.1 TNF SERPINC1 IL6 F3 CRP
21 superior mesenteric artery syndrome 30.1 CRP ALB
22 buerger disease 30.1 SERPINC1 F2 CRP
23 adult respiratory distress syndrome 30.1 TNF PLG IL6 CRP
24 chronic recurrent multifocal osteomyelitis 30.1 TNF IL6 CRP
25 volvulus of midgut 30.1 GPT F3 F2 CRP ALB
26 pancreatitis 30.1 TNF INS IL6 CRP ALB
27 acute pancreatitis 30.1 TNF INS IL6 GPT CRP
28 toxic megacolon 30.0 TNF CRP ALB
29 ischemia 30.0 TNF PLG PIK3C2A MB IL6
30 anuria 30.0 PIK3C2A MB LCN2 F3 F2 CRP
31 factor viii deficiency 30.0 SERPINC1 F9 F8 F7 F3 F2
32 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 30.0 PIK3C2A MB CHKB
33 thrombosis 30.0 SERPINC1 PLG F9 F8 F7 F3
34 peptic ulcer perforation 30.0 CRP ALB
35 hereditary angioedema 29.9 SERPINC1 PLG F2
36 neuroleptic malignant syndrome 29.9 PIK3C2A MB GPT CHKB
37 tendinitis 29.9 TNF IL6 CRP
38 cavernous hemangioma 29.9 SERPINC1 F3 F2 ALB
39 arteriovenous malformation 29.9 PLG F3 F2 ALB
40 cholecystitis 29.9 GPT F2 CRP ALB
41 hepatorenal syndrome 29.9 LCN2 GPT F2 ALB
42 angioedema 29.9 PLG IL6 F2 CRP
43 protein s deficiency 29.9 SERPINC1 F3 F2
44 aortic aneurysm, familial abdominal, 1 29.9 TNF PLG LCN2 IL6 F3 CRP
45 hemoglobinuria 29.9 SERPINC1 MB F2
46 peritonitis 29.9 TNF LCN2 IL6 F2 CRP ALB
47 mitral valve insufficiency 29.8 GPT F3 F2 CRP ALB
48 henoch-schoenlein purpura 29.8 TNF IL6 CRP ALB
49 intermittent claudication 29.8 SERPINC1 IL6 F2 CRP ALB
50 tenosynovitis 29.8 TNF IL6 CRP

Graphical network of the top 20 diseases related to Compartment Syndrome:

Diseases related to Compartment Syndrome

Symptoms & Phenotypes for Compartment Syndrome

UMLS symptoms related to Compartment Syndrome:

muscle weakness; myalgia; muscle cramp; muscle rigidity; muscle spasticity

GenomeRNAi Phenotypes related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ABRA ALB CHKB CRP CYGB F2
2 no effect GR00402-S-2 10.18 ABRA ALB CHKB CRP CYGB F2

MGI Mouse Phenotypes related to Compartment Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 ABRA ALB CHKB CRP CYGB F2
2 muscle MP:0005369 10.16 ALB CHKB CYGB F2 F3 IL6
3 cardiovascular system MP:0005385 10.16 ABRA ALB CRP CYGB F2 F3
4 cellular MP:0005384 10.1 ALB CYGB F2 F3 IL6 INS
5 liver/biliary system MP:0005370 10.09 ALB CYGB F9 IL6 INS LCN2
6 renal/urinary system MP:0005367 10.08 ALB CYGB IL6 INS LCN2 PIK3C2A
7 immune system MP:0005387 9.97 ALB CRP F2 F3 F8 F9
8 adipose tissue MP:0005375 9.95 F2 F7 IL6 INS LCN2 PIK3C2A
9 hematopoietic system MP:0005397 9.73 F2 F3 F8 F9 IL6 INS
10 mortality/aging MP:0010768 9.47 ALB F2 F3 F7 F8 F9

Drugs & Therapeutics for Compartment Syndrome

Drugs for Compartment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
3 Blood Substitutes Phase 4
4 Plasma Substitutes Phase 4
5 Hydroxyethyl Starch Derivatives Phase 4
6 Neurotransmitter Agents Phase 4
abobotulinumtoxinA Phase 4
8 Botulinum Toxins, Type A Phase 4
9 Botulinum Toxins Phase 4
10 Cholinergic Agents Phase 4
Heparin, bovine Approved, Investigational, Withdrawn Phase 3 9005-49-6 22833565 9812414 772
Reviparin Approved, Investigational Phase 3 9041-08-1
13 Vasoconstrictor Agents Phase 3
14 Pharmaceutical Solutions Phase 3
15 Calcium heparin Phase 3
16 Heparin, Low-Molecular-Weight Phase 3
Mepivacaine Approved, Vet_approved Phase 1 96-88-8, 1722-62-9 4062
Prilocaine Approved Phase 1 721-50-6 4906
19 Anesthetics, Local Phase 1
20 Anesthetics Phase 1
Cocaine Approved, Illicit 50-36-2 446220 5760
Furosemide Approved, Vet_approved 54-31-9 3440
23 Analgesics, Opioid
24 Narcotics
25 Liver Extracts
26 diuretics
27 Arginine Vasopressin
28 Vasopressins

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Colloids in Severe Trauma: A Multi-Center Pilot Study of "Crystalloid Only" or "Crystalloid + Colloid" Volume Resuscitation in Trauma Patients (CIST) Completed NCT00890383 Phase 4 tetrastarch (Voluven)
2 Assessment of Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava by Emergency Ultrasonography Before and After Fluid Therapy Completed NCT01553422 Phase 4
3 OnabotulinumtoxinA (Botox) Effect on Pain and Function in Recurrent Chronic Exertional Compartment Syndrome: a Pilot Study Recruiting NCT05006417 Phase 4 Botox
4 Chronic Exertional Compartment Syndrome (CECS) Evaluated With Needle Manometry and Shear Wave Elastography, and Treated With Ultrasound-Guided AbobotulinumtoxinA Not yet recruiting NCT05466539 Phase 4 AbobotulinumtoxinA;Placebo
5 Study of Primary Fascial Closure Rate in Patients With Open Abdomen Treated With Abthera Versus Barker Technique Unknown status NCT02952976 Phase 3
6 The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function in Critically Ill Adults With Intra-abdominal Hypertension and Acute Kidney Injury Unknown status NCT01077895 Phase 3
7 Temporal Trend Analysis of Nurse's Knowledge and Practice Before and After Implementing an Educational Program Regarding Abdominal Compartment Syndrome Unknown status NCT02639013 Phase 3
8 Percutaneous Catheter Decompression in the Treatment of Elevated Intra-abdominal Pressure Completed NCT01230255 Phase 3
9 Diagnosing Chronic Exertional Compartment Syndrome: Measurement of Intra-Compartmental Pressures Using Noninvasive Subharmonic Aided Pressure Estimation (SHAPE) Versus Shear Wave Elastography (SWE). Recruiting NCT05247541 Phase 2, Phase 3 Definity
10 Comparison of Botulinum Toxin to Fasciotomy in Treatment of Chronic Exertional Compartment Syndrome Terminated NCT03339921 Phase 2, Phase 3 Botulinum toxin injections for chronic compartment syndrome
11 OnabotulinumtoxinA (Botox) Effect on Pain and Return to Sport in Chronic Exertional Compartment Syndrome of the Anterior Leg: A Pilot Study Completed NCT03922139 Phase 1, Phase 2 OnabotulinumtoxinA Injection
12 Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS) Recruiting NCT04409600 Phase 2 Saline Injection;Botulinum Toxin Injection
13 Phase I, Arteriocyte Magellan MAR01 Therapy - Compartment Syndrome and Battlefield Trauma Study Protocol Completed NCT01837264 Phase 1
14 Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers Completed NCT04113954 Phase 1 Mepivacaine Injection
15 Management of Compartment Syndrome With Ultrafiltration Completed NCT00022815 Phase 1
16 In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome. Completed NCT01452425 Phase 1
17 Autologous Bone Marrow Mononuclear Cell Administration for Lower Extremity Compartment Syndrome Injury Recruiting NCT03880656 Phase 1
18 Prevalence, Risk Factors, and Prognostic Factors of Intraabdominal Hypertension and Abdominal Compartment Syndrome in Critically Ill Surgical Patients in Ramathibodi Hospital Unknown status NCT03762057
19 Magnetic Resonance (MR) Imaging Quantitative Functional Perfusion Analysis of the Musculoskeletal System: Clinical Application in Non-tumoral Pathology Unknown status NCT02683252
20 Randomized Clinical Trial of Tissue Ultrafiltration and Pressure Monitoring for the Diagnosis and Prevention of Compartment Syndrome Unknown status NCT00681616
21 Surveillance, Prevention and Treatment of Intra-abdominal Hypertension and Abdominal Compartment Syndrome: A Single Center Prospective Cohort Study Unknown status NCT03876418
22 Effects of Perioperative Patient Education Regarding Compartment Syndrome on Post-operative Opioid Consumption Unknown status NCT03359031
23 Double Blinded Study for the Reduction of the Incidence of Fasciotomy Unknown status NCT01879696
24 Evaluating the Diagnostic Performance of Near Infrared Spectroscopy (NIRS) in the Setting of Acute Compartment Syndrome (ACS) in Traumatized Lower Extremities Unknown status NCT03604029
25 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
26 Abdominal Compartment Syndrome : Diagnostic and Prognostic Value of CT Findings - a Prospective Study Unknown status NCT02814734
27 The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension and Abdominal Compartment Syndrome. Unknown status NCT02229695
28 Abdominal Compartment Syndrome and Ruptured Aortic Aneurysm : Validation of a Predictive Test Unknown status NCT02859662
29 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome Unknown status NCT01171638
30 Decompressive Laparotomy With Temporary Abdominal Closure Versus Percutaneous Puncture With Placement of Abdominal Catheter in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis:Multicenter, Randomised, Controlled Study Unknown status NCT00793715
31 Continuous Passive Paracentesis Versus Large Volume Paracentesis in the Prevention and Treatment of Intra-abdominal Hypertension and Abdominal Compartment Syndrome in the Critically Ill Cirrhotic Patient With Ascites Unknown status NCT04322201
32 Physiologic Signals and Signatures With the Accuryn Monitoring System - A Retrospective and Prospective Analysis (The Accuryn Registry) Completed NCT04585555
33 The Application of Near Infrared Spectroscopy (NIRS) in the Detection of Lower Limb Compartment Syndrome Completed NCT00921271
34 The Increase of Intra-abdominal Pressure Can Affect Intra-ocular Pressure. Completed NCT02319213
35 Intra-abdominal Hypertension in Critically Ill Patients Completed NCT02514135
36 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers Completed NCT01123798
37 The Value of Multimodal Monitoring in the Treatment of Compartment Syndrome: a Study Based on Healthy Volunteers Completed NCT04442672
38 Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome Completed NCT01077934
39 Feasibility Study of The Use of FLEX HD® Surgical Implant or STRATTICE® Reconstructive Tissue Matrix in The Closure of Abdominal Wall Defects With Component Separation in Clean or Contaminated Cases Completed NCT01597128
40 Use of Near Infrared Spectroscopy to Detect Muscle Perfusion in the Lower Extremity of Uninjured Subjects Completed NCT01284023
41 Bioelectrical Impedance Analysis Guided-Fluid Management Promotes Primary Fascial Closure of Postinjury Open Abdomen Completed NCT03466684
42 Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity Completed NCT01283451
43 Predicting Acute Compartment Syndrome (PACS) Using Optimized Clinical Assessment, Continuous Pressure Monitoring, and Continuous Tissue Oximetry Completed NCT01561261
44 Non-invasive Limb Compartment Pressure Measurement Completed NCT03730688
45 Clinical Validation of CPM#1 Compression Ratio Measurement on Healthy Volunteers Completed NCT05367921
46 Validation of CPM#1 Compressibility Ratio in a Clinical Study of Healthy Volunteers: Evaluation of the Test-retest Repeatability Completed NCT05483946
47 Clinical Trial of a New Device for Real-Time Muscle Pressure Measurements in Patients With an Upper or Lower Extremity Fracture at Risk for Acute Compartment Syndrome Recruiting NCT04012723
48 Biomarkers of Rhabdomyolysis in the Diagnosis of Acute Compartment Syndrome: Study Protocol of a Prospective Multinational, Multicentre Study in Patients With Tibial Fractures. Recruiting NCT04674592
49 COmpartment Syndrome vaLidation Of Non Invasive Assessment of Tissue Pressure (COLONIA) Recruiting NCT03840434
50 Physiologic Signals and Signatures With the Accuryn Monitoring System - A Retrospective and Prospective Analysis (The Accuryn Registry) Recruiting NCT04669548

Search NIH Clinical Center for Compartment Syndrome

Cochrane evidence based reviews: compartment syndromes

Genetic Tests for Compartment Syndrome

Anatomical Context for Compartment Syndrome

Organs/tissues related to Compartment Syndrome:

MalaCards : Kidney, Bone Marrow, Liver, Bone, Skeletal Muscle, Dorsal Root Ganglion, Skin

Publications for Compartment Syndrome

Articles related to Compartment Syndrome:

(show top 50) (show all 7880)
# Title Authors PMID Year
Do creatine kinase (CK) levels influence the diagnosis or outcome in patients with compartment syndrome? 53 62
16374979 2005
[Neuropathy of common sciatic nerve secondary to compartment syndrome as a complication after bariatric surgery]. 53 62
15726478 2005
Acquired anti-FVIII inhibitors in children. 53 62
11886462 2002
[Pathogenesis of pulmonary thrombosis in Duchenne muscular dystrophy; a consideration from changes in serum CK and LDH levels]. 53 62
10825803 2000
Exertional collapse and sudden death associated with sickle cell trait. 53 62
8677839 1996
[Postoperative bilateral compartment syndrome resulting from prolonged urological surgery in lithotomy position. Serum creatine kinase activity (CK) as a warning signal in sedated, artificially respirated patients]. 53 62
7695079 1995
Telemedicine-guided forearm emergency decompressive fasciotomy for compartment syndrome. 62
33070688 2023
Spontaneous acute forearm compartment syndrome: Case report of a clinical diagnosis with limited imaging options. 62
36324852 2023
Compartment Syndrome in the Foot and Leg. 62
36368837 2023
Spontaneous iliac vein rupture showed by femoral contrast bolus: A case report. 62
36340224 2023
Post-traumatic intra-orbital meningoencephalocele in adults: technical note on a rare entity and review of the literature. 62
36471011 2022
Intra-abdominal hypertension and abdominal compartment syndrome. 62
36194128 2022
Review article: A comprehensive review of unusual causes of acute limb compartment syndrome. 62
36192364 2022
Predictors of acute compartment syndrome in patients with tibial fractures: a meta-analysis. 62
36450888 2022
Point of care ultrasound needle guidance to assist diagnosis of acute gluteal compartment syndrome. 62
36163064 2022
Clinical Consensus on Diagnosis and Treatment of Patients with Chronic Exertional Compartment Syndrome of the Leg: A Delphi Analysis. 62
35904751 2022
Lateral Canthotomy/Cantholysis Performance Gap Analysis and Training Recommendations for Expeditionary Physicians. 62
36461685 2022
Incisional wound closure by sequential partial split-thickness skin grafting following failure of primary abdominal fascia closure after open abdomen management: A case report. 62
36446160 2022
Chronic exertional compartment syndrome in a patient with restrictive cardiomyopathy and portal hypertension. 62
36102848 2022
Periarticular multimodal analgesia in decreasing perioperative pain in tibial plateau fractures: A double blind randomized controlled pilot study. 62
36207154 2022
Role of lower extremity fasciectomy plus fasciotomy for patients with persistent leg pain after stenting for chronic iliofemoral venous obstruction. 62
36248401 2022
Near-infrared spectroscopy (NIRS) measured tissue oxygenation in neonates with gastroschisis: a pilot study. 62
33602021 2022
Data mining for adverse drug reaction signals of daptomycin based on real-world data: a disproportionality analysis of the US Food and Drug Administration adverse event reporting system. 62
36178607 2022
Traumatic testicular compartment syndrome: a rare case of testicular infarction without rupture. 62
36413051 2022
Wells Syndrome Presenting as Atypical Periorbital Cellulitis. 62
35699219 2022
Intrauterine intestinal volvulus without malrotation presenting neonatal abdominal compartment syndrome. 62
36270210 2022
Phlegmasia cerulea dolens causing compartment syndrome. 62
35961832 2022
Resuscitative Endovascular Balloon Occlusion of the Aorta is Associated with Increased Risk of Extremity Compartment Syndrome. 62
36371514 2022
Rapid development of lower leg compartment syndrome following firearm injury in a patient with moderate hemophilia B. 62
36348636 2022
Single direct right axillary artery cannulation using a modified Seldinger technique in minimally invasive cardiac surgery. 62
35639334 2022
Acute Isolated Thenar Compartment Syndrome in a Patient with Evans Syndrome: A Case Report. 62
36427036 2022
Stimulated biofeedback training for a child with Becker muscular dystrophy and compartment syndrome in the left forearm. 62
33541191 2022
VOLCON: a randomized controlled trial investigating complications and functional outcome of volar plating vs casting of unstable distal radius fractures in patients older than 65 years. 62
36443579 2022
Safety and efficacy of long-term emicizumab prophylaxis in hemophilia A with factor VIII inhibitors: A phase 3b, multicenter, single-arm study (STASEY). 62
36397934 2022
Acute Kidney Injury in Patients with Liver Disease. 62
35902128 2022
Vascular Complications With Intra-aortic Balloon Pump (IABP): Experience From a Large Canadian Metropolitan Centre. 62
36444371 2022
Posterior component separation with TAR: lessons learned from our first consecutive 52 cases. 62
36355329 2022
Massive vulvar edema revealing idiopathic systemic capillary leak syndrome. 62
35972575 2022
Compartment syndrome of the hand following CT contrast extravasation. 62
36401155 2022
Well leg compartment syndrome due to the lithotomy position in orthopedic surgery: a report of two cases and a review of the literature. 62
36425587 2022
A case report of furosemide extravasation in the hand: a rare cause of compartment syndrome. 62
36410744 2022
Characteristics and outcomes of patients who undergo fasciotomies for upper arm compartment syndrome. 62
36344794 2022
Is the timing of fixation associated with fracture-related infection among tibial plateau fracture patients with compartment syndrome? A multicenter retrospective cohort study of 729 patients. 62
36064758 2022
A Modern Day Timeline for In-Hospital Monitoring in Perfused, Pulseless Pediatric Supracondylar Humerus Fractures. 62
35980760 2022
The Role of Endovascular Repair of Popliteal Arterial Injuries in the Acute Setting. 62
35760265 2022
Early results of low-velocity ballistic femoral shaft fractures. 62
36163206 2022
[Fractures of tibial shaft and tibial head in winter sports]. 62
36224282 2022
[Noninvasive intra-abdominal pressure measurement]. 62
36214834 2022
Lower leg blood pressure decreases while calf external pressure increases with the angulation of the Trendelenburg position in the lithotomy position with calf- and foot-supported leg holders. 62
36414843 2022
Early Versus Delayed Treatment for Gartland Type III Supracondylar Humeral Fractures in Children: A Systematic Review and Meta-analysis. 62
36092280 2022

Variations for Compartment Syndrome

Expression for Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for Compartment Syndrome

Pathways related to Compartment Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.82 SERPINC1 PLG F9 F8 F7 F3
Show member pathways
12.5 SERPINC1 F9 F8 F7 F3 F2
Show member pathways
Show member pathways
11.71 F9 F8 F7 F2
Show member pathways
11.63 SERPINC1 PLG F9 F8 F7 F3
6 11.59 TNF IL6 CRP
7 11.52 TNF LCN2 IL6
8 11.5 TNF PIK3C2A IL6
9 11.35 TNF INS IL6
Show member pathways
11.3 INS F2 ALB
11 11.29 TNF PLG IL6
Show member pathways
11.13 F9 F7 F2
13 11.04 IL6 PLG TNF
Show member pathways
10.66 F9 F8
15 10.66 GPT F7
16 10.41 TNF IL6 CRP
17 10.4 PLG F2
Show member pathways
10.22 TNF IL6
19 9.93 MB CYGB

GO Terms for Compartment Syndrome

Cellular components related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.35 ALB CRP F2 F3 F7 F8
2 collagen-containing extracellular matrix GO:0062023 10.18 SERPINC1 PLG F9 F7 F3 F2
3 blood microparticle GO:0072562 10.03 SERPINC1 PLG F2 ALB
4 endoplasmic reticulum lumen GO:0005788 9.86 ALB F2 F7 F8 F9 IL6
5 Golgi lumen GO:0005796 9.85 INS F9 F8 F7 F2
6 serine-type endopeptidase complex GO:1905370 9.8 F9 F7 F2
7 extracellular space GO:0005615 9.75 TNF SERPINC1 PLG LCN2 INS IL6
8 serine-type peptidase complex GO:1905286 9.67 F3 F7

Biological processes related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 10.03 TNF INS F7 F3
2 acute-phase response GO:0006953 9.96 CRP F2 F8 IL6 INS
3 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.88 TNF IL6 F2
4 negative regulation of lipid storage GO:0010888 9.8 TNF IL6 CRP
5 blood coagulation GO:0007596 9.8 SERPINC1 PLG F9 F8 F7 F3
6 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.67 F7 F3
7 regulation of body fluid levels GO:0050878 9.46 F9 F8 F7 F2
8 hemostasis GO:0007599 9.17 SERPINC1 PLG F9 F8 F7 F3

Molecular functions related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.86 TNF SERPINC1 INS F3
2 oxygen binding GO:0019825 9.8 MB CYGB ALB
3 serine-type peptidase activity GO:0008236 9.63 PLG F9 F7 F2
4 serine-type endopeptidase activity GO:0004252 9.32 PLG F9 F7 F3 F2
5 enterobactin binding GO:1903981 9.26 LCN2 ALB

Sources for Compartment Syndrome

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
Loading form....