Compartment Syndrome

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Compartment Syndrome

MalaCards integrated aliases for Compartment Syndrome:

Name: Compartment Syndrome 12 74 52 15
Compartment Syndromes 54 43 71
Compartmental Syndrome 12


External Ids:

Disease Ontology 12 DOID:682
ICD9CM 34 958.90
MeSH 43 D003161
NCIt 49 C118422
SNOMED-CT 67 111245009
ICD10 32 T79.A0
UMLS 71 C0009492

Summaries for Compartment Syndrome

MalaCards based summary : Compartment Syndrome, also known as compartment syndromes, is related to anterior compartment syndrome and encephalopathy, progressive, early-onset, with episodic rhabdomyolysis, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Compartment Syndrome is MB (Myoglobin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Compartment syndrome is a condition in which increased pressure within one of the body's anatomical... more...

Related Diseases for Compartment Syndrome

Diseases in the Compartment Syndrome family:

Anterior Compartment Syndrome

Diseases related to Compartment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 892)
# Related Disease Score Top Affiliating Genes
1 anterior compartment syndrome 34.8 MB HECTD4
2 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 31.7 PIK3C2A MB CHKB
3 acute kidney failure 31.0 PIK3C2A MB GPT F2 ALB
4 myoglobinuria 30.9 PIK3C2A MB GPT
5 pain agnosia 30.8 IL6 HECTD4 ALB
6 gas gangrene 30.7 PIK3C2A MB IL6 CRP
7 peroneal nerve paralysis 30.7 MB HECTD4
8 thrombophilia due to thrombin defect 30.7 SERPINC1 F8 F3 F2
9 hemophilia a 30.7 F8 F7 F3
10 pyomyositis 30.6 PIK3C2A MB CRP
11 acquired hemophilia 30.6 F8 F3
12 acquired hemophilia a 30.6 F8 F3
13 limb ischemia 30.6 TNF IL6 F2
14 fasciitis 30.5 TNF IL6 HECTD4 CRP
15 pancreatitis 30.5 TNF SLC17A5 IL6 CRP ALB
16 acute pancreatitis 30.4 TNF IL6 GPT CRP ALB
17 ileus 30.4 TNF IL6 F2 CRP
18 cellulitis 30.4 TNF IL6 CRP
19 vibrio vulnificus infection 30.4 PIK3C2A IL6
20 hepatorenal syndrome 30.4 GPT F2 ALB
21 toxic megacolon 30.4 TNF CRP ALB
22 acute liver failure 30.3 SLC17A5 GPT F2 ALB
23 peritonitis 30.3 TNF IL6 F2 CRP ALB
24 cardiogenic shock 30.3 PIK3C2A CRP
25 paralytic ileus 30.3 GPT F2 CRP ALB
26 cholecystitis 30.2 GPT F2 ALB
27 metabolic acidosis 30.2 IL6 GPT F2 ALB
28 volvulus of midgut 30.2 GPT CRP ALB
29 myositis 30.2 TNF SLC17A5 PIK3C2A MB IL6 CHKB
30 mononeuropathy 30.2 TNF HECTD4 CRP
31 femoral neuropathy 30.1 F3 F2
32 factor viii deficiency 30.1 F8 F7 F3 F2
33 malignant hyperthermia 30.1 PIK3C2A MB IL6 GPT
34 neuroleptic malignant syndrome 30.1 PIK3C2A MB GPT CHKB
35 lymphangitis 30.0 HECTD4 CRP ALB
36 optic nerve disease 30.0 TNF IL6 CRP ALB
37 orbital plasma cell granuloma 30.0 PIK3C2A CRP
38 hemarthrosis 29.9 F8 F7 F3 F2
39 anuria 29.9 PIK3C2A MB GPT F3 F2 CRP
40 tendinitis 29.9 TNF IL6 HECTD4 CRP
41 peptic ulcer perforation 29.9 CRP ALB
42 von willebrand's disease 29.9 F8 F7 F3 F2
43 acute kidney tubular necrosis 29.9 TNF PIK3C2A MB IL6 ALB
44 end stage renal disease 29.9 TNF IL6 CRP ALB
45 toxic shock syndrome 29.9 TNF SERPINC1 IL6 F3 CRP
46 acquired von willebrand syndrome 29.9 F8 F7 F3
47 perinatal necrotizing enterocolitis 29.9 TNF IL6 CRP
48 chickenpox 29.9 TNF IL6 CRP ALB
49 septic arthritis 29.9 TNF IL6 CRP
50 cavernous hemangioma 29.8 SERPINC1 MB F2

Graphical network of the top 20 diseases related to Compartment Syndrome:

Diseases related to Compartment Syndrome

Symptoms & Phenotypes for Compartment Syndrome

UMLS symptoms related to Compartment Syndrome:

muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

MGI Mouse Phenotypes related to Compartment Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 ABRA ALB CRP F2 F3 F7
2 homeostasis/metabolism MP:0005376 9.86 ABRA ALB CHKB CRP F2 F3
3 immune system MP:0005387 9.36 ALB CRP F2 F3 F8 HELLS

Drugs & Therapeutics for Compartment Syndrome

Drugs for Compartment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
Dalteparin Approved Phase 4 9005-49-6
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
Verapamil Approved Phase 4 52-53-9 2520
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
8 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
Choline Approved, Nutraceutical Phase 4 62-49-7 305
10 Anesthetics, General Phase 4
11 Hypnotics and Sedatives Phase 4
12 Anesthetics, Intravenous Phase 4
13 Hydroxyethyl Starch Derivatives Phase 4
14 Plasma Substitutes Phase 4
15 Blood Substitutes Phase 4
16 Heparin, Low-Molecular-Weight Phase 4
17 calcium heparin Phase 4
18 Fibrinolytic Agents Phase 4
19 Hormones Phase 4
20 Anti-Arrhythmia Agents Phase 4
21 Vasodilator Agents Phase 4
22 Calcium, Dietary Phase 4
23 calcium channel blockers Phase 4
24 Cytidine Diphosphate Choline Phase 4
25 Anticoagulants Phase 4
26 Anti-Bacterial Agents Phase 4
27 Amoxicillin-Potassium Clavulanate Combination Phase 4
28 Antibiotics, Antitubercular Phase 4
29 beta-Lactamase Inhibitors Phase 4
30 Anti-Infective Agents Phase 4
31 Anesthetics Phase 4
32 Anesthetics, Local Phase 4
33 Antigen-Antibody Complex Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Tranexamic Acid Approved Phase 3 1197-18-8 5526
Thrombin Approved, Investigational Phase 3
Argatroban Approved, Investigational Phase 3 74863-84-6 152951
38 Hemostatics Phase 3
39 Coagulants Phase 3
40 Antifibrinolytic Agents Phase 3
protease inhibitors Phase 3
42 HIV Protease Inhibitors Phase 3
43 Antithrombins Phase 3
44 Antithrombin III Phase 3
45 Serine Proteinase Inhibitors Phase 3
46 Platelet Aggregation Inhibitors Phase 3
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
Bevacizumab Approved, Investigational Phase 2 216974-75-3
Polidocanol Approved Phase 2 9002-92-0
Enoxaparin Approved Phase 2 9005-49-6 772

Interventional clinical trials:

(show top 50) (show all 144)
# Name Status NCT ID Phase Drugs
1 Prospective, Interventional Multicentre Study on the Effect of Deepening of Sedation on Intra-abdominal Pressure Unknown status NCT02944292 Phase 4 Propofol
2 Assessment of Relation Between Intrabdominal Pressure and Collapsibility Index of Inferior Vena Cava by Emergency Ultrasonography Before and After Fluid Therapy Completed NCT01553422 Phase 4
3 Colloids in Severe Trauma: A Multi-Center Pilot Study of "Crystalloid Only" or "Crystalloid + Colloid" Volume Resuscitation in Trauma Patients (CIST) Completed NCT00890383 Phase 4 tetrastarch (Voluven)
4 Comparison of VERapamil vs. Heparin Therapy on Procedural sUccess During Transradial Coronary Procedures (VERMUT Study) Completed NCT02454491 Phase 4 Heparin;Verapamil
5 A Prospective, Controlled Evaluation of ABRA Abdominal Wall Closure System in Combination With V.A.C. Therapy Compared to V.A.C. Alone in the Management of Open Abdomen Completed NCT00754156 Phase 4
6 The Efficacy of Demineralized Bone Matrix and Autogenous Bone Graft in Accelerated Fracture Healing in Closed Tibia Fracture Completed NCT00299052 Phase 4
7 Clinically-Important Venous Thromboembolism Following Lower Extremity Fractures: Epidemiology & Prevention Completed NCT00187408 Phase 4 Low Molecular Weight Heparin (dalteparin)
8 Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Completed NCT01531543 Phase 4
9 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
10 Routine vs. Clinically-Directed Antibiotic Treatment in Snake Bite With Local Envenomation: a Randomised Controlled Trial Recruiting NCT02570347 Phase 4 Co-amoxiclav
11 Interventional Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in High-risk Patients With Atrial Fibrillation (PRAGUE-17 Study) Recruiting NCT02426944 Phase 4 NOAC
12 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion Enrolling by invitation NCT02972593 Phase 4
13 Hypertonic Saline Resuscitation for Early Closure of Open Abdomen in Trauma Patients Terminated NCT02542241 Phase 4 Sodium Chloride [3%];Sodium Chloride [0.9%]
14 Efficacy and Safety of OctaplasLG Administration vs. Crystalloids (Standard) in Patients With Septic Shock - a Randomized, Controlled, Open-label Investigator-initiated Pilot Trial Terminated NCT02875236 Phase 4 OctaplasLG®;Ringer-acetat
15 A Randomized, Double-blind Controlled Trial of Bupivacaine Extended-release Liposome Injection for Postsurgical Analgesia in Patients Undergoing Open-reduction Internal Fixation of the Distal Radius Terminated NCT02515851 Phase 4 Exparel;Placebo
16 Correlation Between Muscle Oxygenation and Skin Pigmentation Withdrawn NCT00747162 Phase 4
17 Temporal Trend Analysis of Nurse's Knowledge and Practice Before and After Implementing an Educational Program Regarding Abdominal Compartment Syndrome Unknown status NCT02639013 Phase 3
18 The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function in Critically Ill Adults With Intra-abdominal Hypertension and Acute Kidney Injury Unknown status NCT01077895 Phase 3
19 Study of Primary Fascial Closure Rate in Patients With Open Abdomen Treated With Abthera Versus Barker Technique Unknown status NCT02952976 Phase 3
20 Percutaneous Catheter Decompression in the Treatment of Elevated Intra-abdominal Pressure Completed NCT01230255 Phase 3
21 Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury Completed NCT01120730 Phase 3 fluid resuscitation;Fluid resuscitation
22 The Effect of Tranexamic Acid in Ruptured Abdominal Aortic Aneurysms Completed NCT02125890 Phase 3 Tranexamic Acid
23 Comparison of Botulinum Toxin to Fasciotomy in Treatment of Chronic Exertional Compartment Syndrome Recruiting NCT03339921 Phase 2, Phase 3 Botulinum toxin injections for chronic compartment syndrome
24 An Open-Label, Randomised, Active Controlled, Multi-Centre Phase 3 Study to Evaluate the Safety and Efficacy of Danaparoid vs Argatroban in Treatment of Subjects With Acute HIT (HITSOVA Study) Active, not recruiting NCT03809481 Phase 3 Danaparoid Sodium;Argatroban
25 Phase III Study of Usefulness of Near Infrared Spectroscopy to Optimize Tissues Perfusion and Oxygenation in Severe Sepsis Terminated NCT00167596 Phase 2, Phase 3
26 Intravitreal Bevacizumab for Treatment of the Second Eye With Non-Arteritic Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
27 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock Completed NCT01611935 Phase 2 Vasopressin
28 Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease Recruiting NCT03791775 Phase 2 Polidocanol foam (Atossisclerol® 3%)
29 Intermediate Dose Enoxaparin in Hospitalized Patients With Moderate-severe COVID19: A Pilot Phase II Single-arm Study, INHIXACOVID19 Recruiting NCT04427098 Phase 2 Enoxaparin 40 Mg/0.4 mL Injectable Solution;Enoxaparin
30 Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS) Not yet recruiting NCT04409600 Phase 2 Saline Injection;Botulinum Toxin Injection
31 OnabotulinumtoxinA (Botox) Effect on Pain and Return to Sport in Chronic Exertional Compartment Syndrome of the Anterior Leg: A Pilot Study Suspended NCT03922139 Phase 1, Phase 2 OnabotulinumtoxinA Injection
32 Prospective Placebo-Controlled Double-Blinded Trial for High-Dose Vitamin C Administration During the Acute Resuscitative Phase of Severe Thermal Injuries Withdrawn NCT01587261 Phase 2 Vitamin C;Placebo
33 The Curative Effect and Security of Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension Unknown status NCT02543658 Phase 1 Neostigmine;The traditional treatment
34 Phase I, Arteriocyte Magellan MAR01 Therapy - Compartment Syndrome and Battlefield Trauma Study Protocol Completed NCT01837264 Phase 1
35 In Vivo Optical Spectroscopy Monitoring in a New Model of Muscular Compartment Syndrome. Completed NCT01452425 Phase 1
36 Management of Compartment Syndrome With Ultrafiltration Completed NCT00022815 Phase 1
37 A Prospective, Non-Randomized, Open-Label Study on the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
38 Autologous Bone Marrow Mononuclear Cell Administration for Lower Extremity Compartment Syndrome Injury Recruiting NCT03880656 Phase 1
39 Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers Not yet recruiting NCT04113954 Phase 1 Mepivacaine Injection;Normal saline Injection
40 Oral Rehydration Therapy in Burn Patients Phase 1 Terminated NCT02124265 Phase 1 CeraLyte 90
41 Effects of Perioperative Patient Education Regarding Compartment Syndrome on Post-operative Opioid Consumption Unknown status NCT03359031
42 Abdominal Compartment Syndrome and Ruptured Aortic Aneurysm : Validation of a Predictive Test Unknown status NCT02859662
43 Long Term Outcomes of Pediatric Compartment Syndrome Unknown status NCT03540394
44 Decompressive Laparotomy With Temporary Abdominal Closure Versus Percutaneous Puncture With Placement of Abdominal Catheter in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis:Multicenter, Randomised, Controlled Study Unknown status NCT00793715
45 Near Infrared Spectroscopy for Determination of Tissue Oxygenation in Patients Undergoing Robotic Assisted Laparoscopic Surgery in the Trendelenburg Position - A Feasibility Study Unknown status NCT02829242
46 The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome Unknown status NCT01171638
47 Abdominal Compartment Syndrome : Diagnostic and Prognostic Value of CT Findings - a Prospective Study Unknown status NCT02814734
48 Double Blinded Study for the Reduction of the Incidence of Fasciotomy Unknown status NCT01879696
49 Randomized Clinical Trial of Tissue Ultrafiltration and Pressure Monitoring for the Diagnosis and Prevention of Compartment Syndrome Unknown status NCT00681616
50 The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension and Abdominal Compartment Syndrome. Unknown status NCT02229695

Search NIH Clinical Center for Compartment Syndrome

Cochrane evidence based reviews: compartment syndromes

Genetic Tests for Compartment Syndrome

Anatomical Context for Compartment Syndrome

MalaCards organs/tissues related to Compartment Syndrome:

Bone, Liver, Kidney, Skin, Testes, Skeletal Muscle, Heart

Publications for Compartment Syndrome

Articles related to Compartment Syndrome:

(show top 50) (show all 6748)
# Title Authors PMID Year
Do creatine kinase (CK) levels influence the diagnosis or outcome in patients with compartment syndrome? 61 54
16374979 2005
[Neuropathy of common sciatic nerve secondary to compartment syndrome as a complication after bariatric surgery]. 54 61
15726478 2005
Acquired anti-FVIII inhibitors in children. 54 61
11886462 2002
[Pathogenesis of pulmonary thrombosis in Duchenne muscular dystrophy; a consideration from changes in serum CK and LDH levels]. 61 54
10825803 2000
Exertional collapse and sudden death associated with sickle cell trait. 54 61
8677839 1996
[Postoperative bilateral compartment syndrome resulting from prolonged urological surgery in lithotomy position. Serum creatine kinase activity (CK) as a warning signal in sedated, artificially respirated patients]. 61 54
7695079 1995
Effects of durotomy versus myelotomy in the repair of spinal cord injury. 61
32246622 2020
Beware of the sneeze. 61
30978335 2020
Pediatric acute leg compartment syndrome after peroneus longus rupture: a case series. 61
31503106 2020
Risk factors for developing acute compartment syndrome in the pediatric population: a systematic review and meta-analysis. 61
32107640 2020
Orbital compartment syndrome as the first manifestation of SLE. 61
32152917 2020
Tension hydrocele as an additional cause of acute scrotum: case series and literature review. 61
30929051 2020
Outcomes of surgical treatment of the tibial tuberosity fractures in skeletally immature patients: an update. 61
31989257 2020
Management of Gustilo-Anderson Type II and IIIA Open Long Bone Fractures in Children: Which Wounds Require a Second Washout? 61
32501910 2020
Outcomes and Predictors of Popliteal Artery Injury in Pediatric Trauma. 61
31978483 2020
Flexible intramedullary nailing in the treatment of forearm fractures in children and adolescents, a systematic review. 61
32025135 2020
[Indications for Surgical and Interventional Therapy of Acute Pancreatitis]. 61
32557429 2020
Utilization of Botulinum Toxin for Musculoskeletal Disorders. 61
32516192 2020
Compartment syndrome of the leg after thyroid hormone withdrawal; two cases and a systematic review of the literature. 61
32503586 2020
Classical-like Ehlers-Danlos syndrome: a clinical description of 20 newly identified individuals with evidence of tissue fragility. 61
32572181 2020
Vipera snakebite in Europe: a systematic review of a neglected disease. 61
32530549 2020
Superficial femoral artery pseudoaneurysm, compartment syndrome, and deep vein thrombosis after total knee arthroplasty. 61
32577468 2020
Management of acute extensive portal vein thrombosis: the complexity and morbidity. 61
32565434 2020
Use of Nonvascularized Fascia in Liver Transplantation. 61
32204902 2020
Systematic Review of Outcome Parameters Following Treatment of Chronic Exertional Compartment Syndrome in the Lower Leg. 61
32526086 2020
Abdominal compartment syndrome after r-EVAR: a systematic review with meta-analysis on incidence and mortality. 61
32519533 2020
Perfusion Pressure Lacks Diagnostic Specificity for the Diagnosis of Acute Compartment Syndrome. 61
32332336 2020
Acute compartment syndrome in children; beware of "silent" compartment syndrome: A CARE-compliant case report. 61
32501996 2020
Compartment Syndrome in Operatively Managed Pediatric Monteggia Fractures and Equivalents. 61
32496461 2020
Hepatic Compartment Syndrome After a Right-sided Diaphragm Plication. 61
31606517 2020
Treatment Strategy of Endovascular Versus Open Repair for Ruptured Abdominal Aortic Aneurysm Based on Fitzgerald Classification. 61
32505681 2020
Diffuse infantile hepatic hemangiomas in a patient with Beckwith-Wiedemann syndrome: A new association? 61
32573107 2020
Vision loss associated with orbital surgery - a major review. 61
31573370 2020
Multiple subcutaneous haematomas of the legs causing skin necrosis in an elderly patient affected by corticosteroid-induced skin atrophy: Case report and review of literature. 61
31972900 2020
Wunderlich syndrome secondary to cyst rupture and concurrent anticoagulation. 61
32544052 2020
Abdominal Wall Defects. 61
32482700 2020
Near-fatal poisoning after ricin injection. 61
32475181 2020
Upper extremity exertional rhabdomyolysis: MR imaging findings in four cases. 61
32346455 2020
[Gluteal compartment syndrome after immobilization following opioid abuse]. 61
32140813 2020
Amputation in crush syndrome: A case report. 61
32563818 2020
Analysis of Normal High-Frequency Intracranial Pressure Values and Treatment Threshold in Neurocritical Care Patients: Insights into Normal Values and a Potential Treatment Threshold. 61
32539101 2020
Right Colectomy with Absorbable Mesh Repair as a Salvage Solution for the Management of Giant Incisional Hernia with Loss of Domain: Results of a Bicentric Study. 61
32016544 2020
Management of Pain Associated with Fractures. 61
32236905 2020
Resuscitation with albumin using BET formula keeps at bay fluid administration in burned patients. An observational study. 61
31848084 2020
Timing of Surgery for Pediatric Supracondylar Humerus Fractures and Early Postoperative Results. 61
32312197 2020
Bench Validation of a Handcrafted Prototype Catheter for Intra-gastric Pressure Monitoring. 61
32016541 2020
Complications of type II supracondylar humerus fractures treated at a specialized paediatric centre. 61
32549738 2020
[Current treatment strategies for lower leg fractures in adults]. 61
32399649 2020
Bothrops atrox Snakebite: How a Bad Decision May Lead to a Chronic Disability: A Case Report. 61
32456876 2020
Do Hospital or Surgeon Volume Affect Outcomes After Surgical Management of Tibial Shaft Fractures? 61
31688437 2020

Variations for Compartment Syndrome

Expression for Compartment Syndrome

Search GEO for disease gene expression data for Compartment Syndrome.

Pathways for Compartment Syndrome

GO Terms for Compartment Syndrome

Cellular components related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TNF SERPINC1 PLG IL6 F8 F7
2 collagen-containing extracellular matrix GO:0062023 9.77 SERPINC1 PLG F7 F3 F2
3 platelet alpha granule lumen GO:0031093 9.58 PLG F8 ALB
4 blood microparticle GO:0072562 9.56 SERPINC1 PLG F2 ALB
5 endoplasmic reticulum lumen GO:0005788 9.43 SERPINC1 IL6 F8 F7 F2 ALB
6 extracellular space GO:0005615 9.36 TNF SERPINC1 PLG IL6 GPT F8
7 serine-type peptidase complex GO:1905286 9.16 F7 F3

Biological processes related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.76 F8 F7 F2 ERGIC1
2 cellular protein metabolic process GO:0044267 9.72 SERPINC1 PLG IL6 F2 ALB
3 positive regulation of JAK-STAT cascade GO:0046427 9.54 TNF IL6 F2
4 negative regulation of fibrinolysis GO:0051918 9.48 PLG F2
5 acute-phase response GO:0006953 9.46 IL6 F8 F2 CRP
6 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.43 F7 F3
7 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
8 blood coagulation GO:0007596 9.43 SERPINC1 PLG F8 F7 F3 F2
9 blood coagulation, extrinsic pathway GO:0007598 9.4 F7 F3
10 hemostasis GO:0007599 9.1 SERPINC1 PLG F8 F7 F3 F2

Molecular functions related to Compartment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.92 PLG F7 F3 F2

Sources for Compartment Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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