MCID: CMP003
MIFTS: 28

Compensatory Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Compensatory Emphysema

MalaCards integrated aliases for Compensatory Emphysema:

Name: Compensatory Emphysema 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10031
ICD9CM 36 518.2
SNOMED-CT 69 33325001
ICD10 34 J98.3
UMLS 74 C0155918

Summaries for Compensatory Emphysema

MalaCards based summary : Compensatory Emphysema is related to pauci-immune glomerulonephritis and rhabdoid tumor predisposition syndrome 1. An important gene associated with Compensatory Emphysema is BMP7 (Bone Morphogenetic Protein 7), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Pulmonary Surfactants and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and eye, and related phenotypes are hearing/vestibular/ear and integument

Related Diseases for Compensatory Emphysema

Diseases related to Compensatory Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pauci-immune glomerulonephritis 10.0 BMP7 CCN2
2 rhabdoid tumor predisposition syndrome 1 9.9 IGF1R MUC1
3 renal fibrosis 9.8 BMP7 CCN2
4 sarcoma, synovial 9.8 IGF1R MUC1
5 connective tissue disease 9.8 CCN2 MUC1
6 dry eye syndrome 9.7 FGF7 MUC1
7 pancreas adenocarcinoma 9.6 IGF1R MUC1
8 kidney disease 9.6 BMP7 CCN2 MUC1
9 pulmonary fibrosis, idiopathic 9.4 CCN2 FGF7 MUC1

Comorbidity relations with Compensatory Emphysema via Phenotypic Disease Network (PDN):


Heart Disease

Graphical network of the top 20 diseases related to Compensatory Emphysema:



Diseases related to Compensatory Emphysema

Symptoms & Phenotypes for Compensatory Emphysema

MGI Mouse Phenotypes related to Compensatory Emphysema:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.33 BMP7 CCN2 IGF1R
2 integument MP:0010771 9.26 BMP7 CCN2 FGF7 IGF1R
3 skeleton MP:0005390 8.92 BMP7 CCN2 FGF7 IGF1R

Drugs & Therapeutics for Compensatory Emphysema

Drugs for Compensatory Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pulmonary Surfactants Not Applicable
2 Respiratory System Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates Unknown status NCT02598648 Not Applicable

Search NIH Clinical Center for Compensatory Emphysema

Genetic Tests for Compensatory Emphysema

Anatomical Context for Compensatory Emphysema

MalaCards organs/tissues related to Compensatory Emphysema:

42
Lung, Kidney, Eye, Pancreas

Publications for Compensatory Emphysema

Articles related to Compensatory Emphysema:

# Title Authors Year
1
Compensatory emphysema shown by computed tomography. ( 7116777 )
1982
2
New pathological findings in emphysema of childhood. 3. Unilateral congenital emphysema with hypoplasia--and compensatory emphysema of contralateral lung. ( 5576537 )
1971

Variations for Compensatory Emphysema

Expression for Compensatory Emphysema

Search GEO for disease gene expression data for Compensatory Emphysema.

Pathways for Compensatory Emphysema

Pathways related to Compensatory Emphysema according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 BMP7 CCN2 FGF7 IGF1R MUC1
2
Show member pathways
13.26 BMP7 CCN2 FGF7 IGF1R
3
Show member pathways
13.12 BMP7 CCN2 FGF7 IGF1R
4
Show member pathways
13.1 BMP7 CCN2 FGF7 IGF1R
5
Show member pathways
12.98 BMP7 CCN2 FGF7 IGF1R
6
Show member pathways
12.88 BMP7 CCN2 FGF7 IGF1R
7
Show member pathways
12.84 BMP7 CCN2 FGF7 IGF1R
8
Show member pathways
12.78 BMP7 CCN2 FGF7 IGF1R
9
Show member pathways
12.6 BMP7 CCN2 FGF7 IGF1R
10
Show member pathways
12.55 BMP7 CCN2 FGF7 IGF1R
11
Show member pathways
12.32 BMP7 CCN2 FGF7
12
Show member pathways
11.85 BMP7 CCN2 FGF7 IGF1R
13 11.78 BMP7 CCN2
14
Show member pathways
11.7 BMP7 CCN2 FGF7
15 11.67 CCN2 MUC1
16
Show member pathways
11.67 BMP7 CCN2 FGF7 IGF1R
17 11.36 BMP7 IGF1R
18 10.93 BMP7 CCN2 FGF7
19 10.61 BMP7 CCN2 FGF7 IGF1R
20 10.53 BMP7 CCN2 FGF7 IGF1R

GO Terms for Compensatory Emphysema

Cellular components related to Compensatory Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 8.96 BMP7 MUC1
2 extracellular region GO:0005576 8.92 BMP7 CCN2 FGF7 MUC1

Biological processes related to Compensatory Emphysema according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.63 CCN2 FGF7 IGF1R
2 epidermis development GO:0008544 9.51 CCN2 FGF7
3 regulation of signaling receptor activity GO:0010469 9.5 BMP7 CCN2 FGF7
4 response to estradiol GO:0032355 9.49 BMP7 CCN2
5 ossification GO:0001503 9.48 BMP7 CCN2
6 fibroblast growth factor receptor signaling pathway GO:0008543 9.43 CCN2 FGF7
7 response to wounding GO:0009611 9.4 CCN2 FGF7
8 negative regulation of cell death GO:0060548 9.37 BMP7 CCN2
9 response to peptide hormone GO:0043434 9.26 BMP7 CCN2
10 positive regulation of cell death GO:0010942 9.16 BMP7 CCN2
11 positive regulation of cell differentiation GO:0045597 8.96 BMP7 CCN2
12 branching involved in salivary gland morphogenesis GO:0060445 8.62 BMP7 FGF7

Molecular functions related to Compensatory Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor binding GO:0005520 9.16 CCN2 IGF1R
2 growth factor activity GO:0008083 9.13 BMP7 CCN2 FGF7
3 heparin binding GO:0008201 8.8 BMP7 CCN2 FGF7

Sources for Compensatory Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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