Complement Component 3 Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CMP064 MIFTS: 34	Complement Component 3 Deficiency Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Complement Component 3 Deficiency

MalaCards integrated aliases for Complement Component 3 Deficiency:

Name: Complement Component 3 Deficiency ¹² ¹⁵

C3 Deficiency ¹² ⁷¹

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8354

NCIt ⁴⁹ C9468

SNOMED-CT ⁶⁷ 771443008

UMLS ⁷¹ C1332655

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Summaries for Complement Component 3 Deficiency

Disease Ontology : ¹² A complement deficiency that is characterized by deficiency of complement component 3 that increases susceptibility to infection and autoimmune diseases and has material basis in autosomal recessive inheritance of mutation in the C3 gene on chromosome 19p13.3, has symptom recurrent bacterial infections.

MalaCards based summary : Complement Component 3 Deficiency, also known as c3 deficiency, is related to complement factor i deficiency and neisseria meningitidis infection, and has symptoms including recurrent bacterial infections An important gene associated with Complement Component 3 Deficiency is C3 (Complement C3), and among its related pathways/superpathways are Innate Immune System and Creation of C4 and C2 activators. Affiliated tissues include t cells, skin and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁴ Complement component 3, often simply called C3, is a protein of the immune system. It plays a central... more...

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Related Diseases for Complement Component 3 Deficiency

Diseases related to Complement Component 3 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)

#	Related Disease	Score	Top Affiliating Genes
1	complement factor i deficiency	30.7	CR1 CFP CFI C4B C4A C3
2	neisseria meningitidis infection	29.9	MBL2 CFP CD46 C3
3	membranoproliferative glomerulonephritis	29.7	CFP CFHR2 CD46 C4A C3
4	proliferative glomerulonephritis	29.6	CR1 CFHR2 CD55 C3
5	genetic atypical hemolytic-uremic syndrome	29.4	CFI CD46 C3
6	vasculitis	29.4	MBL2 C3 C1S
7	immune-complex glomerulonephritis	29.3	CFI CFHR2 C4B
8	end stage renal disease	29.2	CFI CD46 C3
9	lyme disease	29.1	CFI CFHR2 C4A C3
10	iga glomerulonephritis	29.0	MBL2 MASP1 CFP CFHR2 C3
11	meningitis	29.0	MBL2 CFP CFI CD55 CD46 C3
12	lupus erythematosus	28.7	CR1 C4B C4A C3 C1S C1R
13	hemoglobinuria	28.3	CR1 CFI CD59 CD55 C3
14	paroxysmal nocturnal hemoglobinuria	28.3	CR1 CFI CD59 CD55 C3
15	glomerulonephritis	26.8	MBL2 MASP1 CR1 CFP CFI CD55
16	complement deficiency	26.7	MBL2 CFP CFI CFHR2 CD59 CD55
17	complement component 5 deficiency	26.7	CR1 CFP CFHR2 CD55 CD46 C5AR2
18	systemic lupus erythematosus	26.2	MBL2 CR1 CFI CFHR2 CD55 CD46
19	complement component 3 deficiency, autosomal recessive	13.0
20	dense deposit disease	10.4	CFHR2 C3
21	louse-borne relapsing fever	10.4	C4B C3
22	anti-basement membrane glomerulonephritis	10.3	CFP CFHR2
23	juvenile dermatitis herpetiformis	10.3	C4B C4A
24	relapsing fever	10.3	CFHR2 C4B C3
25	acquired angioedema	10.3	C3 C1S
26	acute poststreptococcal glomerulonephritis	10.3	CFP CFHR2 C3
27	systemic lupus erythematosus 16	10.3	C4A C1R
28	meningococcemia	10.2	MBL2 CFP
29	periodontal ehlers-danlos syndrome	10.2	C1S C1R
30	bacterial infectious disease	10.2
31	pediatric systemic lupus erythematosus	10.2	C4B C4A C3
32	ehlers-danlos syndrome, periodontal type, 2	10.2	C1S C1R
33	ehlers-danlos syndrome, periodontal type, 1	10.2	C1S C1R
34	monkeypox	10.2	CD55 C4B
35	blood protein disease	10.2	CFHR2 C4B C4A
36	mannose-binding lectin deficiency	10.2	MBL2 CFP C5AR1
37	acute proliferative glomerulonephritis	10.2	C5AR1 C3
38	congenital intrinsic factor deficiency	10.1	C1S C1R
39	c1 inhibitor deficiency	10.1	C1S C1R
40	capillary leak syndrome	10.1	C4A C3 C1S
41	arthus reaction	10.1	CR1 CD46 C5AR1
42	primary cutaneous b-cell lymphoma	10.1	CD59 CD55
43	tick-borne relapsing fever	10.1	CFHR2 C4B C4A C3
44	mollaret meningitis	10.1
45	multiple congenital anomalies-hypotonia-seizures syndrome 2	10.1	CD59 CD55
46	gingival recession	10.1	C1S C1R
47	scabies	10.1	MBL2 CFP
48	angioedema	10.0	C4A C1S C1R
49	t-cell/histiocyte rich large b cell lymphoma	10.0	VSIG4 CR1
50	diffuse glomerulonephritis	10.0	MASP1 CFP C3

Graphical network of the top 20 diseases related to Complement Component 3 Deficiency:

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Symptoms & Phenotypes for Complement Component 3 Deficiency

Symptoms:

¹²

• recurrent bacterial infections

GenomeRNAi Phenotypes related to Complement Component 3 Deficiency according to GeneCards Suite gene sharing:

²⁶ (show all 21)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.05	CD59
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	10.05	C4A C4B
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-109	10.05	CD59
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.05	CD59
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.05	CD59
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-136	10.05	CD59
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-150	10.05	CD59
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.05	CD59
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-153	10.05	CD59
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.05	C4A C4B
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	10.05	CD59
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	10.05	CD59
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-191	10.05	CD59
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-28	10.05	CD59
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.05	CD59
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.05	C4A C4B
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.05	C4A C4B
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	10.05	CD59
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-8	10.05	C4A C4B
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.05	CD59
21	Reduced mammosphere formation	GR00396-S	9.1	C3 C4A C5AR1 C5AR2 CD59 VSIG4

MGI Mouse Phenotypes related to Complement Component 3 Deficiency:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	9.17	C3 C3AR1 C4B CD55 CD59 CFI

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Drugs & Therapeutics for Complement Component 3 Deficiency

Search Clinical Trials , NIH Clinical Center for Complement Component 3 Deficiency

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Genetic Tests for Complement Component 3 Deficiency

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Anatomical Context for Complement Component 3 Deficiency

MalaCards organs/tissues related to Complement Component 3 Deficiency:

⁴⁰

T Cells, Skin, Brain, Liver, Spinal Cord, Kidney, Neutrophil

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Publications for Complement Component 3 Deficiency

Articles related to Complement Component 3 Deficiency:

(show top 50) (show all 160)

#	Title	Authors	PMID	Year
1	Complement component 3 prevents imiquimod-induced psoriatic skin inflammation by inhibiting apoptosis in mice. ⁶¹	Zheng QY...Xu GL	32535539	2020
2	IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation. ⁶¹	Zhang X...Guo J	31996021	2020
3	Successful simultaneous liver-kidney transplantation for renal failure associated with hereditary complement C3 deficiency. ⁶¹	Nayagam JS...Suddle A	31970896	2020
4	Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis. ⁶¹	Zhong F...He S	31076642	2019
5	Safety profile after prolonged C3 inhibition. ⁶¹	Reis ES...Lambris JD	30217791	2018
6	Complement Component C3 Promotes Cerebral Ischemia/Reperfusion Injury Mediated by TLR2/NFκB Activation in Diabetic Mice. ⁶¹	Lin Z...Dai H	29948726	2018
7	C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism. ⁶¹	Ling GS...Botto M	29724957	2018
8	IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement. ⁶¹	van Dam AD...van Harmelen V	28852207	2018
9	Reduced bone loss in a murine model of postmenopausal osteoporosis lacking complement component 3. ⁶¹	MacKay DL...Dennis JE	28667799	2018
10	Complement C3 Affects Rac1 Activity in the Developing Brain. ⁶¹	Gorelik A...Reiner O	29867343	2018
11	Cutaneous Vasculitis and Digital Ischaemia Caused by Heterozygous Gain-of-Function Mutation in C3. ⁶¹	Omoyinmi E...Eleftheriou D	30443255	2018
12	Complement Dependence of Murine Costimulatory Blockade-Resistant Cellular Cardiac Allograft Rejection. ⁶¹	Chun N...Heeger PS	28444847	2017
13	Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. ⁶¹	Wu L...Moghimi SM	28846925	2017
14	Hereditary Homozygous C3 Deficiency. ⁶¹	Bathia JN...Guha S	28435995	2017
15	Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. ⁶¹	Shi Q...Lemere CA	28566429	2017
16	Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. ⁶¹	Harder JM...John SWM	28446616	2017
17	Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. ⁶¹	Subramaniam S...Ruf W	28223279	2017
18	NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH. ⁶¹	Yao ST...Ran QS	27933491	2017
19	Complement component 3 deficiency prolongs MHC-II disparate skin allograft survival by increasing the CD4(+) CD25(+) regulatory T cells population. ⁶¹	Zheng QY...Zhang KQ	27641978	2016
20	Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites. ⁶¹	Biryukov S...Stoute JA	27333049	2016
21	Skipping of exon 27 in C3 gene compromises TED domain and results in complete human C3 deficiency. ⁶¹	da Silva KR...Isaac L	26847111	2016
22	C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning. ⁶¹	Kalm M...Blomgren K	27029069	2016
23	Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice. ⁶¹	Na M...Jin T	26787717	2016
24	Efficacy of Targeted Complement Inhibition in Experimental C3 Glomerulopathy. ⁶¹	Ruseva MM...Pickering MC	26047789	2016
25	Clinical characteristics and genotype-phenotype correlations in C3 deficiency. ⁶¹	Okura Y...Ariga T	26435005	2016
26	Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement. ⁶¹	Alawieh A...Tomlinson S	26714866	2015
27	Dysregulation of adaptive immune responses in complement C3-deficient patients. ⁶¹	Pekkarinen PT...Arstila TP	25446578	2015
28	Complement deficiency promotes cutaneous wound healing in mice. ⁶¹	Rafail S...Lambris JD	25548229	2015
29	rs2230201 polymorphism may dictate complement C3 levels and response to treatment in chronic hepatitis C patients. ⁶¹	Chowdhury SJ...Kar P	24995942	2015
30	The effect of Tlr4 and/or C3 deficiency and of neonatal gene therapy on skeletal disease in mucopolysaccharidosis VII mice. ⁶¹	Xing EM...Ponder KP	25559179	2015
31	Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus. ⁶¹	Shi ZR...Wang L	25307291	2015
32	Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency. ⁶¹	Kurvers RA...van de Kar NC	23963626	2014
33	Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarction. ⁶¹	Wysoczynski M...Rokosh G	24806427	2014
34	Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation. ⁶¹	Ghannam A...Drouet C	24321396	2014
35	C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. ⁶¹	Baudino L...Botto M	24474777	2014
36	Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice. ⁶¹	Bandini S...Cavallo F	24228231	2013
37	Impaired intestinal tolerance in the absence of a functional complement system. ⁶¹	Pekkarinen PT...Arstila TP	23098807	2013
38	Expressions of C5a and its receptor CD88 after spinal cord injury in C3-deficient mice. ⁶¹	Guo Q...Lin S	23033813	2013
39	Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. ⁶¹	Kandasamy M...Sivasankar B	23326231	2013
40	Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited. ⁶¹	Miller EC...Atkinson JP	23117396	2012
41	Rheumatoid factor-positive synovitis in a patient with C3 deficiency. ⁶¹	Okura Y...Ariga T	23043374	2012
42	Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement. ⁶¹	Zhou J...Mrug M	22518005	2012
43	The effect of anti-Anisakis simplex antibody levels on C3 and C4 complement components in human sera. ⁶¹	Garcia-Hernandez P...Cuellar C	21729389	2012
44	Genetic Deficiency of Complement Component 3 Does Not Alter Disease Progression in a Mouse Model of Huntington's Disease. ⁶¹	Larkin PB...Muchowski PJ	23097680	2012
45	The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. ⁶¹	Zhang J...Peng Z	22019898	2011
46	A protective role of complement component 3 in T cell-mediated skin inflammation. ⁶¹	Purwar R...Werfel T	21569105	2011
47	A novel mutation in the C3 gene and recurrent invasive pneumococcal infection: a clue for vaccine development. ⁶¹	Goldberg M...Katz Y	21676463	2011
48	Complement C3 deficiency prevent against the onset of streptozotocin-induced autoimmune diabetes involving expansion of regulatory T cells. ⁶¹	Gao X...Fu Z	21767994	2011
49	Novel compound heterozygous mutations in the C3 gene: hereditary C3 deficiency. ⁶¹	Okura Y...Ariga T	21501302	2011
50	Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. ⁶¹	Bauer EM...Bauer PM	22194859	2011

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Genes for Complement Component 3 Deficiency

Genes related to Complement Component 3 Deficiency (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	C3	Complement C3	Protein Coding	28.29	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
2	CFHR2	Complement Factor H Related 2	Protein Coding	8.44	DISEASES inferred ¹⁵ ¹⁵
3	C3AR1	Complement C3a Receptor 1	Protein Coding	7.88	DISEASES inferred ¹⁵
4	C5AR1	Complement C5a Receptor 1	Protein Coding	7.81	DISEASES inferred ¹⁵
5	CD46	CD46 Molecule	Protein Coding	7.08	DISEASES inferred ¹⁵
6	CFP	Complement Factor Properdin	Protein Coding	7.06	DISEASES inferred ¹⁵
7	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	7.03	DISEASES inferred ¹⁵
8	C4B	Complement C4B (Chido Blood Group)	Protein Coding	6.94	DISEASES inferred ¹⁵
9	C4A	Complement C4A (Rodgers Blood Group)	Protein Coding	6.89	DISEASES inferred ¹⁵
10	C1R	Complement C1r	Protein Coding	6.83	DISEASES inferred ¹⁵
11	C5AR2	Complement Component 5a Receptor 2	Protein Coding	6.76	DISEASES inferred ¹⁵
12	MBL2	Mannose Binding Lectin 2	Protein Coding	6.66	DISEASES inferred ¹⁵
13	C1S	Complement C1s	Protein Coding	6.62	DISEASES inferred ¹⁵
14	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	6.52	DISEASES inferred ¹⁵
15	VSIG4	V-Set And Immunoglobulin Domain Containing 4	Protein Coding	6.29	DISEASES inferred ¹⁵
16	MASP1	Mannan Binding Lectin Serine Peptidase 1	Protein Coding	6.26	DISEASES inferred ¹⁵
17	CFI	Complement Factor I	Protein Coding	6.14	DISEASES inferred ¹⁵
18	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	6.1	DISEASES inferred ¹⁵

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Variations for Complement Component 3 Deficiency

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Expression for Complement Component 3 Deficiency

Search GEO for disease gene expression data for Complement Component 3 Deficiency.

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Pathways for Complement Component 3 Deficiency

Pathways related to Complement Component 3 Deficiency according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.86	MBL2 MASP1 CR1 CFP CFI CD59
2	Creation of C4 and C2 activators ⁶⁵ Show member pathways Alternative complement activation ⁶⁵ Classical antibody-mediated complement activation ⁶⁵ Complement cascade ⁶⁵ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁵ Initial triggering of complement ⁶⁵ Lectin pathway of complement activation ⁶⁵ Terminal pathway of complement ⁶⁵	12.19	MBL2 MASP1 CR1 CFI CD59 CD55
3	Immune response Lectin induced complement pathway ²² Show member pathways Activation of C3 and C5 ⁶⁵ Complement Activation Pathways ⁶⁶ Immune response Alternative complement pathway ²² Immune response Classical complement pathway ²² Regulation of Complement cascade ⁶⁵	12.06	MBL2 MASP1 CR1 CFP CFI CD59
4	Staphylococcus aureus infection ³⁶	11.94	MBL2 MASP1 CFI C5AR1 C4B C4A
5	Complement Pathway ⁶³ Show member pathways Alternative Complement Pathway ⁶³ Classical Complement Pathway ⁶³ Complement Activation ¹ Lectin Induced Complement Pathway ⁶³	11.88	MBL2 MASP1 CFP CD55 C4B C4A
6	Phagosome ³⁶	11.81	MBL2 C3 C1R
7	Complement and coagulation cascades ³⁶ ¹	11.69	VSIG4 MBL2 MASP1 CR1 CFI CFHR2
8	Pertussis ³⁶	11.68	C4B C4A C3 C1S C1R
9	Hematopoietic cell lineage ³⁶	11.6	CR1 CD59 CD55

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GO Terms for Complement Component 3 Deficiency

Cellular components related to Complement Component 3 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.97	CR1 CFI CD59 CD55 CD46 C4B
2	extracellular space	GO:0005615	9.85	MBL2 MASP1 CFP CFI CD59 C4B
3	cell surface	GO:0009986	9.8	MBL2 CR1 CD59 CD55 CD46 C5AR1
4	secretory granule membrane	GO:0030667	9.54	CR1 CD55 C5AR1
5	extracellular region	GO:0005576	9.4	MBL2 MASP1 CFP CFI CFHR2 CD59
6	blood microparticle	GO:0072562	9.35	C4B C4A C3 C1S C1R

Biological processes related to Complement Component 3 Deficiency according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	10.1	VSIG4 MBL2 MASP1 CR1 CFP CFI
2	neutrophil degranulation	GO:0043312	9.98	CR1 CFP CD59 CD55 C5AR1 C3AR1
3	inflammatory response	GO:0006954	9.95	C5AR2 C5AR1 C4B C4A C3AR1 C3
4	complement activation	GO:0006956	9.86	MBL2 MASP1 CFP C4B C4A C3
5	complement activation, classical pathway	GO:0006958	9.85	MBL2 CR1 CFI CD55 CD46 C4B
6	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.84	CD55 C5AR2 C5AR1 C3AR1
7	negative regulation of endopeptidase activity	GO:0010951	9.79	C4B C4A C3
8	positive regulation of angiogenesis	GO:0045766	9.79	C5AR1 C3AR1 C3
9	innate immune response	GO:0045087	9.77	VSIG4 MBL2 MASP1 CR1 CFP CFI
10	viral entry into host cell	GO:0046718	9.76	CR1 CD55 CD46
11	phospholipase C-activating G protein-coupled receptor signaling pathway	GO:0007200	9.73	C5AR2 C5AR1 C3AR1
12	positive regulation of vascular endothelial growth factor production	GO:0010575	9.69	C5AR1 C3AR1 C3
13	complement receptor mediated signaling pathway	GO:0002430	9.67	CR1 C5AR2 C5AR1 C3AR1
14	complement activation, alternative pathway	GO:0006957	9.63	VSIG4 CFP C3
15	positive regulation of neutrophil chemotaxis	GO:0090023	9.61	C5AR1 C3AR1
16	positive regulation of macrophage chemotaxis	GO:0010759	9.6	C5AR1 C3AR1
17	amyloid-beta clearance	GO:0097242	9.59	C5AR1 C3
18	complement activation, lectin pathway	GO:0001867	9.58	MBL2 MASP1
19	positive regulation of apoptotic cell clearance	GO:2000427	9.58	C4B C4A C3
20	opsonization	GO:0008228	9.57	MBL2 C4B
21	regulation of complement-dependent cytotoxicity	GO:1903659	9.55	CD59 CD55
22	negative regulation of complement activation, alternative pathway	GO:0045957	9.52	VSIG4 CR1
23	regulation of complement activation	GO:0030449	9.5	CR1 CFP CFI CFHR2 CD59 CD55
24	complement component C5a signaling pathway	GO:0038178	9.49	C5AR2 C5AR1

Molecular functions related to Complement Component 3 Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	9.62	MASP1 CFI C1S C1R
2	virus receptor activity	GO:0001618	9.61	CR1 CD55 CD46
3	serine-type peptidase activity	GO:0008236	9.46	MASP1 CFI C1S C1R
4	endopeptidase inhibitor activity	GO:0004866	9.43	C4B C4A C3
5	complement binding	GO:0001848	9.4	CD59 C4B
6	complement component C3b binding	GO:0001851	9.37	VSIG4 CR1
7	complement component C5a receptor activity	GO:0004878	8.96	C5AR2 C5AR1
8	complement receptor activity	GO:0004875	8.8	C5AR2 C5AR1 C3AR1

Sources

Sources for Complement Component 3 Deficiency

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia