MCID: CMP035
MIFTS: 30

Complete Atrioventricular Canal

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Complete Atrioventricular Canal

MalaCards integrated aliases for Complete Atrioventricular Canal:

Name: Complete Atrioventricular Canal 53 59
Common Atrioventricular Canal 53 59 73
Complete Atrioventricular Septal Defect 53 59
Cavc 53 59
Complete Atrioventricular Canal Defect 29

Characteristics:

Orphanet epidemiological data:

59
complete atrioventricular canal
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 59 ORPHA1329
UMLS via Orphanet 74 C0221215 C0344787
ICD10 via Orphanet 34 Q21.2
SNOMED-CT via HPO 69 253273004 396351009 59494005
UMLS 73 C0221215

Summaries for Complete Atrioventricular Canal

MalaCards based summary : Complete Atrioventricular Canal, also known as common atrioventricular canal, is related to complete atrioventricular canal-tetralogy of fallot syndrome and complete atrioventricular canal-ventricle hypoplasia syndrome. An important gene associated with Complete Atrioventricular Canal is LEFTY2 (Left-Right Determination Factor 2). The drugs Dextrans and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotypes are abnormality of the cardiac septa and abnormal cardiac septum morphology

Related Diseases for Complete Atrioventricular Canal

Graphical network of the top 20 diseases related to Complete Atrioventricular Canal:



Diseases related to Complete Atrioventricular Canal

Symptoms & Phenotypes for Complete Atrioventricular Canal

Human phenotypes related to Complete Atrioventricular Canal:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the cardiac septa 59 Very frequent (99-80%)
2 abnormal cardiac septum morphology 32 hallmark (90%) HP:0001671

Drugs & Therapeutics for Complete Atrioventricular Canal

Drugs for Complete Atrioventricular Canal (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dextrans Phase 2
2 Pharmaceutical Solutions Phase 2
3 Plasma Substitutes Phase 2
4 Anticoagulants Phase 2
5 Blood Substitutes Phase 2
6
Nitric Oxide Approved Phase 1 10102-43-9 145068 160954
7 carnitine Nutraceutical Phase 1
8
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 68602 5311068
9
Acetaminophen Approved Not Applicable 103-90-2 1983
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
11
Mechlorethamine Approved, Investigational 51-75-2 4033
12 Analgesics Not Applicable
13 Central Nervous System Depressants Not Applicable
14 Adjuvants, Anesthesia Not Applicable
15 Adrenergic Agents Not Applicable
16 Adrenergic Agonists Not Applicable
17 Adrenergic alpha-2 Receptor Agonists Not Applicable
18 Adrenergic alpha-Agonists Not Applicable
19 Narcotics Not Applicable
20 Neurotransmitter Agents Not Applicable
21 Analgesics, Non-Narcotic Not Applicable
22 Analgesics, Opioid Not Applicable
23 Anesthetics Not Applicable
24 Anesthetics, General Not Applicable
25 Anesthetics, Intravenous Not Applicable
26 Peripheral Nervous System Agents Not Applicable
27 Hypnotics and Sedatives Not Applicable
28 Antipyretics Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Study of Triostat in Infants During Heart Surgery Completed NCT00027417 Phase 3 Liothyronine sodium/triiodothyronine
2 Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol Completed NCT01120964 Phase 1, Phase 2 Intravenous L-Citrulline;Placebo of Intravenous L-Citrulline
3 Hypertonic Saline Dextran in Pediatric Cardiac Surgery Completed NCT00199771 Phase 2 7.5% NaCl in 6% dextran 70 solution
4 Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle Recruiting NCT03079401 Phase 1, Phase 2
5 Aberrations in Carnitine Homeostasis in Congenital Heart Disease With Increased Pulmonary Blood Flow Unknown status NCT01825369 Phase 1 IV L-carnitine
6 Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular Disease Completed NCT00005322
7 Molecular Genetic Epidemiology of Three Cardiac Defects -SCOR in Pediatric Cardiovascular Disease Completed NCT00005546
8 Measures to Lower the Stress Response in Pediatric Cardiac Surgery Completed NCT00848393 Not Applicable Fentanyl;Fentanyl;Dexmedetomidine and Fentanyl
9 Evolution of Two Cohorts of Children (Univentricular and Bi-ventricular Heart) After Strapping of the Pulmonary Artery Completed NCT03047343
10 Acetaminophen for Oxidative Stress After Cardiopulmonary Bypass Completed NCT01228305 Not Applicable
11 National Congenital Heart Disease Audit Recruiting NCT02303535
12 Infant Weight Gain With Trisomy 21 and CAVC Terminated NCT00327951
13 Optimal Timing for Repair of Left to Right Shunt Lesions Terminated NCT00229827

Search NIH Clinical Center for Complete Atrioventricular Canal

Genetic Tests for Complete Atrioventricular Canal

Genetic tests related to Complete Atrioventricular Canal:

# Genetic test Affiliating Genes
1 Complete Atrioventricular Canal Defect 29

Anatomical Context for Complete Atrioventricular Canal

MalaCards organs/tissues related to Complete Atrioventricular Canal:

41
Heart

Publications for Complete Atrioventricular Canal

Articles related to Complete Atrioventricular Canal:

(show top 50) (show all 141)
# Title Authors Year
1
Retrospective study of complete atrioventricular canal defects: Anesthetic and perioperative challenges. ( 29336386 )
2018
2
Cardiac Function After Tetralogy of Fallot/Complete Atrioventricular Canal Repair. ( 28329461 )
2017
3
Complete Atrioventricular Canal Defect: Towards a More Physiological Repair. ( 28705664 )
2017
4
Early Complete Atrioventricular Canal Repair Yields Outcomes Equivalent to Late Repair. ( 25886812 )
2015
5
Palliation of Truncus Arteriosus Associated With Complete Atrioventricular Canal-Results of Single Ventricle Palliation. ( 26467884 )
2015
6
Atypical Williams syndrome in an infant with complete atrioventricular canal defect. ( 26271350 )
2015
7
A Novel Technique for Repair of Complete Atrioventricular Canal Defect: The Central Patch Technique. ( 24958047 )
2014
8
A Rare Case of Pulmonary Artery Sling and Complete Atrioventricular Canal Defect in an Infant With Trisomy 21. ( 24958055 )
2014
9
Fetal complete common atrioventricular canal defect: spontaneous closure of the ventricular septal defect--in utero anatomic evolution and postnatal outcomes. ( 23799731 )
2013
10
Noonan syndrome with complete atrioventricular canal defect with pulmonary stenosis. ( 24055746 )
2013
11
Changes in left atrioventricular valve geometry after surgical repair of complete atrioventricular canal. ( 22078711 )
2012
12
Anesthesia for an infant with Beckwith-Wiedman syndrome who underwent open heart surgery for complete atrioventricular canal defect. ( 25631696 )
2012
13
Descriptive epidemiology of non-syndromic complete atrioventricular canal defects. ( 23061687 )
2012
14
Improving left ventricular outflow tract obstruction repair in common atrioventricular canal defects. ( 22626757 )
2012
15
Complete atrioventricular canal with guarded primum septal defect. ( 21188369 )
2011
16
Prolonged QT in a 13-year-old patient with Down syndrome and complete atrioventricular canal defect. ( 22008496 )
2011
17
Individualized approach to repair of complete atrioventricular canal: selective use of the traditional single-patch technique versus the Australian technique. ( 23804726 )
2010
18
No-patch technique for complete atrioventricular canal repair. ( 20609816 )
2010
19
Complete atrioventricular canal in a dog. ( 20615778 )
2010
20
Management of complete atrioventricular canal defect with aortic arch obstruction: an unresolved debate. ( 23804821 )
2010
21
Complete atrioventricular canal repair under 1 year: Rastelli one-patch procedure yields excellent long-term results. ( 19049757 )
2008
22
Prenatal diagnosis of complete atrioventricular canal associated with tetralogy of Fallot. ( 17663460 )
2008
23
Traditional single patch versus the "Australian" technique for repair of complete atrioventricular canal defects. ( 18958557 )
2008
24
Overview: history, anatomy, timing, and results of complete atrioventricular canal. ( 17433985 )
2007
25
Primary repair of d-transposition with complete atrioventricular canal defect. ( 17244905 )
2007
26
Complete atrioventricular canal: comparison of modified single-patch technique with two-patch technique. ( 18036931 )
2007
27
What is the best technique for repair of complete atrioventricular canal? ( 17983953 )
2007
28
Analysis of surgical outcome in complex double-outlet right ventricle with heterotaxy syndrome or complete atrioventricular canal defect. ( 16798205 )
2006
29
No patch technique for complete atrioventricular canal repair. ( 17670589 )
2006
30
Complete atrioventricular canal. ( 16722604 )
2006
31
No patch technique for complete atrioventricular canal repair. ( 17670590 )
2006
32
Biventricular repair of right-dominant complete atrioventricular canal defect. ( 17072673 )
2006
33
Complete atrioventricular canal defect in a foal: Clinical and pathological features. ( 19083319 )
2005
34
Biventricular repair of complete atrioventricular canal, double-outlet right ventricle and common atrium using a modified double switch technique. A valid alternative to univentricular procedure. ( 17670392 )
2005
35
[Infections as a preoperative problem in patients with tetralogy of Fallot (TOF) associated with complete atrioventricular canal septal defect (AVC)]. ( 15724657 )
2004
36
Complete atrioventricular canal and tetralogy of Fallot with pulmonary atresia. ( 15464457 )
2004
37
Complete endocardial cushion defect (complete atrioventricular canal) manifested in adult life by Streptococcus mitis endocarditis of the common atrioventricular valve. ( 12727016 )
2003
38
One-stage repair of complete atrioventricular canal, double-outlet right ventricle, left superior vena cava, cor triatriatum and pulmonary stenosis. ( 12537251 )
2003
39
Play safe: band the late presenting complete atrioventricular canal. ( 12079967 )
2002
40
Single-stage anatomical repair of complete atrioventricular canal, double-outlet right ventricle, and cor triatriatum using ventricular septal defect translocation. ( 11996287 )
2002
41
Unusual association of hypertrophic cardiomyopathy with complete atrioventricular canal defect and Down syndrome. ( 11093415 )
2000
42
Surgery of the complete atrioventricular canal: relationship between age at operation, mitral regurgitation, size of the ventricular septum defect, additional malformations and early postoperative outcome. ( 10545678 )
1999
43
Successful total correction of complete atrioventricular canal, total anomalous pulmonary venous drainage and unroofed coronary sinus in an infant. ( 10077381 )
1999
44
Two-stage correction of transposition of great arteries with complete atrioventricular canal. ( 9456129 )
1998
45
Double-outlet right ventricle with complete atrioventricular canal. ( 9768963 )
1998
46
The two-patch technique for complete atrioventricular canal. ( 9109223 )
1997
47
Patient selection for repair of complete atrioventricular canal guided by echocardiography. ( 8817140 )
1996
48
Surgical management of complete atrioventricular canal associated with tetralogy of Fallot. ( 8782923 )
1996
49
Polysplenia syndrome with common atrioventricular canal and persistent truncus arteriosus. ( 8693496 )
1995
50
Patient selection for repair of complete atrioventricular canal guided by echocardiography. ( 7608465 )
1995

Variations for Complete Atrioventricular Canal

Expression for Complete Atrioventricular Canal

Search GEO for disease gene expression data for Complete Atrioventricular Canal.

Pathways for Complete Atrioventricular Canal

GO Terms for Complete Atrioventricular Canal

Sources for Complete Atrioventricular Canal

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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