MCID: CMP006
MIFTS: 36

Complex Partial Epilepsy

Categories: Neuronal diseases

Aliases & Classifications for Complex Partial Epilepsy

MalaCards integrated aliases for Complex Partial Epilepsy:

Name: Complex Partial Epilepsy 12 15 17
Epilepsy, Complex Partial 43 71
Complex Partial Epileptic Seizure 12
Epilepsy, Psychomotor 12
Psychomotor Epilepsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12382
MeSH 43 D017029
SNOMED-CT 67 407675009
UMLS 71 C0085417

Summaries for Complex Partial Epilepsy

MalaCards based summary : Complex Partial Epilepsy, also known as epilepsy, complex partial, is related to alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality and kohlschutter-tonz syndrome, and has symptoms including seizures An important gene associated with Complex Partial Epilepsy is SLC4A10 (Solute Carrier Family 4 Member 10), and among its related pathways/superpathways is Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics. The drugs Gabapentin and Vigabatrin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Focal seizures (also called partial seizures and localized seizures) are seizures which affect initially... more...

Related Diseases for Complex Partial Epilepsy

Diseases related to Complex Partial Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality 12.7
2 kohlschutter-tonz syndrome 11.2
3 schindler disease, type i 11.0
4 focal epilepsy 10.7
5 epilepsy 10.5
6 visual epilepsy 10.3
7 seizure disorder 10.3
8 intestinal impaction 10.2 SLC4A7 SLC4A5
9 cataract 14, multiple types 10.2 SLC4A5 SLC4A10
10 corneal dystrophy and perceptive deafness 10.2 SLC4A7 SLC4A10
11 corneal dystrophy, band-shaped 10.1 SLC4A7 SLC4A5 SLC4A10
12 temporal lobe epilepsy 10.1
13 subacute sclerosing panencephalitis 10.0
14 kluver-bucy syndrome 10.0
15 measles 10.0
16 amnestic disorder 9.9
17 status epilepticus 9.9
18 tic disorder 9.9
19 epilepsy, idiopathic generalized 9.9 STXBP1 SLC4A10 OPRM1
20 retinitis pigmentosa 9.9
21 bardet-biedl syndrome 4 9.9
22 chorea, childhood-onset, with psychomotor retardation 9.9
23 chromosome 15q24 deletion syndrome 9.9
24 neuroretinitis 9.9
25 meningoencephalitis 9.9
26 microcephaly 9.9
27 paranoid schizophrenia 9.9
28 choreatic disease 9.9
29 retinitis 9.9
30 adenoma 9.9
31 narcolepsy 9.9
32 alopecia 9.9
33 central pain syndrome 9.9
34 osteochondroma 9.9
35 precocious puberty 9.9
36 central precocious puberty 9.9
37 idiopathic central precocious puberty 9.9
38 gilles de la tourette syndrome 9.8
39 hand skill, relative 9.8
40 arts syndrome 9.8
41 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.8
42 west syndrome 9.8
43 finger agnosia 9.8
44 stuttering 9.8
45 tetanus 9.8
46 reading disorder 9.8
47 agnosia 9.8
48 herpes simplex 9.8
49 encephalitis 9.8
50 prrt2-associated paroxysmal movement disorders 9.8

Graphical network of the top 20 diseases related to Complex Partial Epilepsy:



Diseases related to Complex Partial Epilepsy

Symptoms & Phenotypes for Complex Partial Epilepsy

UMLS symptoms related to Complex Partial Epilepsy:


seizures

GenomeRNAi Phenotypes related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.44 ATP5ME
2 Decreased viability GR00240-S-1 9.44 FIZ1
3 Decreased viability GR00249-S 9.44 ATP8A1 GAL SLC4A7
4 Decreased viability GR00381-A-1 9.44 FIZ1
5 Decreased viability GR00386-A-1 9.44 ATP8A1 JRK SLC4A10 SLC4A7
6 Decreased viability GR00402-S-2 9.44 ATP5ME JRK OPRM1

MGI Mouse Phenotypes related to Complex Partial Epilepsy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 CLN8 GAL MBD5 OPRM1 SLC25A12 SLC4A10

Drugs & Therapeutics for Complex Partial Epilepsy

Drugs for Complex Partial Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Vigabatrin Approved Phase 4 68506-86-5, 60643-86-9 5665
3
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
4 Excitatory Amino Acid Antagonists Phase 4
5 Neurotransmitter Agents Phase 4
6 Anticonvulsants Phase 4
7 Psychotropic Drugs Phase 4
8 Anti-Anxiety Agents Phase 4
9 Hormones Phase 4
10 Analgesics Phase 4
11 Calcium, Dietary Phase 4
12 calcium channel blockers Phase 4
13
Calcium Nutraceutical Phase 4 7440-70-2 271
14
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 3 439-14-5 3016
15
Zonisamide Approved, Investigational Phase 3 68291-97-4 5734
16 Gastrointestinal Agents Phase 3
17 Anesthetics Phase 3
18 Hypnotics and Sedatives Phase 3
19 Pharmaceutical Solutions Phase 3
20 Anesthetics, General Phase 3
21 Antiemetics Phase 3
22 GABA Modulators Phase 3
23 Anesthetics, Intravenous Phase 3
24
Huperzine A Approved, Experimental Phase 1 102518-79-6
25
Valproic acid Approved, Investigational Phase 1 99-66-1 3121
26
Lapatinib Approved, Investigational Phase 1 231277-92-2, 388082-78-8 208908 9941095
27
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
28
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
29
Lenalidomide Approved Phase 1 191732-72-6 216326
30
Sunitinib Approved, Investigational Phase 1 557795-19-4, 341031-54-7 5329102
31 Cholinergic Agents Phase 1
32 Neuroprotective Agents Phase 1
33 Cholinesterase Inhibitors Phase 1
34 Protective Agents Phase 1
35
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
36 Protein Kinase Inhibitors Phase 1
37 Immunologic Factors Phase 1
38 Angiogenesis Inhibitors Phase 1

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Parallel-group Multi-center Comparative Flexible-dose Trial Of Pregabalin Versus Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures. Completed NCT00537940 Phase 4 Pregabalin;Gabapentin
2 An Open Label, Randomized Study Prospectively Examining the Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin Terminated NCT01128712 Phase 4 Pregabalin;Pregabalin
3 Sabril for Treatment of Adult Refractory Partial Seizures Symptomatic of Tuberous Sclerosis: An Open Label, Phase IV Prospective Safety and Tolerability Study Terminated NCT01266291 Phase 4 vigabatrin
4 A Phase 3, Randomized, Double-blind, Parallel, Placebo-controlled, Multicenter Study, With Optional Open-label Continuation, Of The Efficacy And Safety Of Vanquix(tm) Auto-injector (Diazepam Injection) For The Management Of Selected, Refractory, Patients With Epilepsy Who Require Intermittent Medical Intervention To Control Episodes Of Acute Repetitive Seizures Completed NCT00319501 Phase 3 Placebo;Vanquix Auto-Injector (Diazepam Injection)
5 The Open Label Extension Portion of the Study Entitled A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Carisbamate as Adjunctive Therapy in Subjects With Partial Onset Seizures. Completed NCT00744731 Phase 3 placebo;carisbamate
6 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Carisbamate as Adjunctive Therapy in Subjects With Partial Onset Seizures. Completed NCT00740623 Phase 3 Carisbamate;placebo;Carisbamate
7 Pregabalin BID Open-Label Add-On Trial: A Follow-Up Study To Determine Long-Term Safety and Efficacy in Patients With Partial Seizures Completed NCT00143143 Phase 3 Pregabalin
8 A Double-Blind, Randomized, Multicenter, Parallel Group Study to Establish Dose-Response, Safety, and Efficacy of Zonegran (Zonisamide) as Monotherapy in Patients With Newly Diagnosed Epilepsy Completed NCT00056576 Phase 3 Zonisamide
9 Epilepsy Phase III Trial Completed NCT00433667 Phase 3 RWJ-333369
10 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of RWJ-333369 as Adjunctive Therapy in Subjects With Partial Onset Seizures Followed by an Open-Label Extension Study. Completed NCT00425282 Phase 3 RWJ-333369
11 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of RWJ 333369 as Adjunctive Therapy in Subjects With Partial Onset Seizures Followed by an Open-Label Extension Study: Open-Label Extension Period Completed NCT00991757 Phase 3 carisbamate
12 A Treatment Protocol for Ganaxolone as add-on Therapy in Adult Patients With Uncontrolled Partial-onset Seizures Deriving Benefit From Protocol 1042-0601 Completed NCT01002820 Phase 2 ganaxolone
13 Evaluation of the Bioavailability, Safety, and Tolerability of BIS-001 ER Following Multiple Dose Administration in Healthy Subjects Completed NCT03156439 Phase 1 BIS-001 ER
14 A Multi-Arm Complete Phase 1 Trial of Valproic Acid-Based 2-Agent Oral Regimens for Patients With Advanced Solid Tumor Completed NCT00495872 Phase 1 Dasatinib;Erlotinib;Lapatinib;Lenalidomide;Sorafenib;Sunitinib;Valproic Acid
15 Sabril Patient Registry Completed NCT01073579 Sabril®
16 The Effect of Vigabatrin on Cerebral Blood Flow and Glucose Metabolism Completed NCT00001489
17 Evaluation and Treatment of Patients With Epilepsy Terminated NCT00013845

Search NIH Clinical Center for Complex Partial Epilepsy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carbamazepine
Divalproex Sodium
felbamate
phenacemide
Sodium Valproate
Valproic Acid

Cochrane evidence based reviews: epilepsy, complex partial

Genetic Tests for Complex Partial Epilepsy

Anatomical Context for Complex Partial Epilepsy

MalaCards organs/tissues related to Complex Partial Epilepsy:

40
Brain, Temporal Lobe, Occipital Lobe, Parietal Lobe, Cortex, Amygdala, Heart

Publications for Complex Partial Epilepsy

Articles related to Complex Partial Epilepsy:

(show top 50) (show all 250)
# Title Authors PMID Year
1
A novel MBD5 mutation in an intellectually disabled adult female patient with epilepsy: Suggestive of early onset dementia? 61
31290275 2019
2
Characterizing Brain Connectivity From Human Electrocorticography Recordings With Unobserved Inputs During Epileptic Seizures. 61
31113298 2019
3
Seizures and Encephalitis in Myelin Oligodendrocyte Glycoprotein IgG Disease vs Aquaporin 4 IgG Disease. 61
29131884 2018
4
A Comparison of Vagal Nerve Stimulation and Responsive Neurostimulation for the Treatment of Medically Refractory Complex Partial Epilepsy. 61
30149389 2018
5
A neurodevelopmental disorder with a nonsense mutation in the Ox-2 antigen domain of the amyloid precursor protein (APP) gene. 61
28102781 2017
6
Interpretation of the Precision Matrix and Its Application in Estimating Sparse Brain Connectivity during Sleep Spindles from Human Electrocorticography Recordings. 61
28095202 2017
7
Anterior thalamic nucleus deep brain Stimulation (DBS) for drug-resistant complex partial seizures (CPS) with or without generalization: long-term evaluation and predictive outcome. 61
26153778 2015
8
An 18-Year-Old Woman With Snoring and Refractory Epilepsy. 61
26238837 2015
9
Complex Partial Epilepsy Associated with Temporal Lobe Developmental Venous Anomaly. 61
26060525 2015
10
Executive Function Performance for Children With Epilepsy Localized to the Frontal or Temporal Lobes. 61
25495770 2015
11
Soren Kierkegaard (1813-55): a bicentennial pathographical review. 61
24573750 2013
12
Febrile seizures: recent developments and unanswered questions. 61
23846392 2013
13
Heart rate recovery in epilepsy. 61
22510003 2012
14
Manipulative and antisocial behavior in an 11-year-old boy with epilepsy. 61
22566031 2012
15
Emergence of complex partial epilepsy-like experiences following closed head injuries: personality variables and neuropsychological profiles. 61
22206825 2012
16
Practical neurology--5: Recurrent unresponsive episodes and seizures. 61
22107008 2011
17
Ictal barking as a manifestation of temporal lobe epilepsy. 61
21880548 2011
18
Sudden unexpected death in epilepsy in children. 61
20500437 2011
19
Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma. 61
20358309 2011
20
Autism in two females with duplications involving Xp11.22-p11.23. 61
21418194 2011
21
Lamotrigine treatment of a patient affected by epilepsy and anxiety disorder. 61
21448112 2011
22
Evaluation of partial epilepsy in Iran: role of video-EEG, EEG, and MRI with epilepsy protocol. 61
24250836 2011
23
Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms. 61
21127692 2010
24
[Treatment of childhood epilepsies: Japanese Expert Consensus study and a comparison of the results with those of the USA and EU]. 61
20666130 2010
25
Management of refractory complex partial seizures: current state of the art. 61
20628630 2010
26
Alteration in chromogranin A, obestatin and total ghrelin levels of saliva and serum in epilepsy cases. 61
20172008 2010
27
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. 61
19845738 2010
28
Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. 61
21274347 2010
29
Features of a subset of children with complex partial epilepsy requiring combination therapy for effective seizure control. 61
19494358 2010
30
Assessment of the attention impairment in absence epilepsy: comparison of visual and auditory P300. 61
19414047 2009
31
[Panic attacks simulated by occipital lobe seizures]. 61
19415605 2009
32
Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy. 61
19470965 2009
33
In-hospital complications of epilepsy surgery: a six-year nationwide experience. 61
19718552 2009
34
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. 61
18509280 2008
35
Re: Atypical language in lesional and nonlesional complex partial epilepsy. 61
18519879 2008
36
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. 61
18413482 2008
37
Atypical language in lesional and nonlesional complex partial epilepsy. 61
17967992 2007
38
Magnetoencephalographic mapping of interictal spike propagation: a technical and clinical report. 61
17846196 2007
39
Gustav Flaubert's "nervous disease": an autobiographic and epileptological approach. 61
17681494 2007
40
Therapy-related acute nonlymphoblastic leukemia following mitoxantrone therapy in a patient with multiple sclerosis. 61
17939254 2007
41
Effect of vagal nerve stimulation in a case of Tourette's syndrome and complex partial epilepsy. 61
16703589 2006
42
Generalized tonic-clonic seizures detected by implantable loop recorder devices: diagnosing more than cardiac arrhythmias. 61
16818222 2006
43
[The utility of interictal SPECT in temporal lobe epilepsy]. 61
16788864 2006
44
A comparison of the circadian rhythms and the levels of melatonin in patients with diurnal and nocturnal complex partial seizures. 61
16524783 2006
45
Prolonged use of phenytoin, carbamazepine or valproate monotherapy on plasma levels of folate and B(12): a comparison between epileptic patients with or without cardiovascular disorders. 61
16648782 2006
46
EEG/fMRI study of ictal and interictal epileptic activity: methodological issues and future perspectives in clinical practice. 61
17239107 2006
47
Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the rat. 61
16379585 2005
48
Seizure focus affects regional language networks assessed by fMRI. 61
16301489 2005
49
Mental health symptoms in partial epilepsy. 61
15939187 2005
50
Comparison of voxel-based 3-D MRI analysis and subtraction ictal SPECT coregistered to MRI in focal epilepsy. 61
15998582 2005

Variations for Complex Partial Epilepsy

Expression for Complex Partial Epilepsy

Search GEO for disease gene expression data for Complex Partial Epilepsy.

Pathways for Complex Partial Epilepsy

Pathways related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10 ATP5ME ATP5F1D

GO Terms for Complex Partial Epilepsy

Cellular components related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 presynapse GO:0098793 9.43 STXBP1 SLC4A10 ROGDI
2 perikaryon GO:0043204 9.33 SLC4A10 ROGDI OPRM1
3 axon GO:0030424 9.26 STXBP1 SLC4A10 ROGDI OPRM1
4 mitochondrial proton-transporting ATP synthase complex GO:0005753 8.62 ATP5ME ATP5F1D

Biological processes related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.8 SLC4A7 SLC4A5 SLC4A10 ATP5ME ATP5F1D
2 sodium ion transport GO:0006814 9.61 SLC4A7 SLC4A5 SLC4A10
3 sodium ion transmembrane transport GO:0035725 9.54 SLC4A7 SLC4A5 SLC4A10
4 cristae formation GO:0042407 9.51 ATP5ME ATP5F1D
5 anion transmembrane transport GO:0098656 9.5 SLC4A7 SLC4A5 SLC4A10
6 ATP biosynthetic process GO:0006754 9.49 ATP5ME ATP5F1D
7 mitochondrial ATP synthesis coupled proton transport GO:0042776 9.48 ATP5ME ATP5F1D
8 ATP synthesis coupled proton transport GO:0015986 9.46 ATP5ME ATP5F1D
9 bicarbonate transport GO:0015701 9.43 SLC4A7 SLC4A5 SLC4A10
10 inorganic anion transport GO:0015698 9.33 SLC4A7 SLC4A5 SLC4A10
11 anion transport GO:0006820 9.13 SLC4A7 SLC4A5 SLC4A10
12 regulation of intracellular pH GO:0051453 8.8 SLC4A7 SLC4A5 SLC4A10

Molecular functions related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anion transmembrane transporter activity GO:0008509 9.33 SLC4A7 SLC4A5 SLC4A10
2 proton-transporting ATP synthase activity, rotational mechanism GO:0046933 9.32 ATP5ME ATP5F1D
3 anion:anion antiporter activity GO:0015301 9.26 SLC4A5 SLC4A10
4 inorganic anion exchanger activity GO:0005452 9.13 SLC4A7 SLC4A5 SLC4A10
5 sodium:bicarbonate symporter activity GO:0008510 8.8 SLC4A7 SLC4A5 SLC4A10

Sources for Complex Partial Epilepsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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