MCID: CMP006
MIFTS: 33

Complex Partial Epilepsy

Categories: Neuronal diseases

Aliases & Classifications for Complex Partial Epilepsy

MalaCards integrated aliases for Complex Partial Epilepsy:

Name: Complex Partial Epilepsy 12 15 17
Epilepsy, Complex Partial 45 74
Complex Partial Epileptic Seizure 12
Epilepsy, Psychomotor 12
Psychomotor Epilepsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12382
MeSH 45 D017029
SNOMED-CT 69 84340007
UMLS 74 C0085417

Summaries for Complex Partial Epilepsy

MalaCards based summary : Complex Partial Epilepsy, also known as epilepsy, complex partial, is related to epilepsy and alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality, and has symptoms including seizures An important gene associated with Complex Partial Epilepsy is SLC4A10 (Solute Carrier Family 4 Member 10). The drugs Gabapentin and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Focal seizures (also called partial seizures and localized seizures) are seizures which affect initially... more...

Related Diseases for Complex Partial Epilepsy

Diseases related to Complex Partial Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 epilepsy 29.7 ADSL CLN8 JRK
2 alopecia, psychomotor epilepsy, pyorrhea, and mental subnormality 12.2
3 alopecia, epilepsy, pyorrhea, mental subnormality 11.7
4 schindler disease, type i 10.9
5 narcolepsy 9.9
6 gilles de la tourette syndrome 9.8
7 tetanus 9.8
8 reading disorder 9.8
9 focal epilepsy 9.8
10 herpes simplex 9.8
11 encephalitis 9.8
12 herpes simplex encephalitis 9.8
13 depression 9.8

Graphical network of the top 20 diseases related to Complex Partial Epilepsy:



Diseases related to Complex Partial Epilepsy

Symptoms & Phenotypes for Complex Partial Epilepsy

UMLS symptoms related to Complex Partial Epilepsy:


seizures

GenomeRNAi Phenotypes related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.32 ADSL CLN8
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.32 ADSL
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.32 CLN8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.32 ADSL
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.32 CLN8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.32 ADSL
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.32 CLN8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.32 ADSL
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.32 ADSL

Drugs & Therapeutics for Complex Partial Epilepsy

Drugs for Complex Partial Epilepsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
2
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
3
Vigabatrin Approved Phase 4 68506-86-5, 60643-86-9 5665
4
Calcium Approved, Nutraceutical Phase 4,Phase 3 7440-70-2 271
5 Antimanic Agents Phase 4
6 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
7 Peripheral Nervous System Agents Phase 4,Phase 3
8 Excitatory Amino Acid Antagonists Phase 4
9 Hormones Phase 4,Phase 3
10 Psychotropic Drugs Phase 4,Phase 3
11 calcium channel blockers Phase 4,Phase 3
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
13 Anti-Anxiety Agents Phase 4,Phase 3
14 Analgesics Phase 4,Phase 3
15 Calcium, Dietary Phase 4,Phase 3
16 Anticonvulsants Phase 4,Phase 3,Phase 2
17 Excitatory Amino Acids Phase 4
18 Tranquilizing Agents Phase 4,Phase 3
19 GABA Agents Phase 4,Phase 3
20
Levetiracetam Approved, Investigational Phase 3 102767-28-2 441341
21
Zonisamide Approved, Investigational Phase 3 68291-97-4 5734
22
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 3 439-14-5 3016
23 Nootropic Agents Phase 3
24 Gastrointestinal Agents Phase 3
25 Hypnotics and Sedatives Phase 3
26 Pharmaceutical Solutions Phase 3
27 Anesthetics, General Phase 3
28 Adjuvants, Anesthesia Phase 3
29 Antiemetics Phase 3
30 GABA Modulators Phase 3
31 Neuromuscular Agents Phase 3
32 Anesthetics Phase 3,Phase 2
33 Anesthetics, Intravenous Phase 3
34 Autonomic Agents Phase 3
35 Pregnanolone Phase 2 128-20-1
36
Huperzine A Approved, Experimental Phase 1 102518-79-6
37 Protective Agents Phase 1
38 Neuroprotective Agents Phase 1
39 Cholinesterase Inhibitors Phase 1
40 Cholinergic Agents Phase 1

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures Completed NCT00537940 Phase 4 Pregabalin;Gabapentin
2 Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients Terminated NCT01266291 Phase 4 vigabatrin
3 Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin Terminated NCT01128712 Phase 4 Pregabalin;Pregabalin
4 Pregabalin Versus Levetiracetam In Partial Seizures Completed NCT00537238 Phase 3 pregabalin;levetiracetam
5 Dose Response Study of Zonegran in Patients With Newly Diagnosed Epilepsy Completed NCT00056576 Phase 3 Zonisamide
6 Pregabalin Open-Label Extension Trial in Patients With Partial Seizures Completed NCT00143143 Phase 3 Pregabalin
7 An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures. Completed NCT00991757 Phase 3 carisbamate
8 An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures Completed NCT00744731 Phase 3 placebo;carisbamate
9 A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures. Completed NCT00740623 Phase 3 Carisbamate;placebo;Carisbamate
10 A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. Completed NCT00433667 Phase 3 RWJ-333369
11 A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. Completed NCT00425282 Phase 3 RWJ-333369
12 Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures. Completed NCT00319501 Phase 3 Placebo;Vanquix Auto-Injector (Diazepam Injection)
13 A Treatment Use Protocol for Subjects Continuing on From the Open-label Extension 0601 Completed NCT01002820 Phase 2 ganaxolone
14 Bioavailability, Safety, and Tolerability of BIS-001 ER Completed NCT03156439 Phase 1 BIS-001 ER
15 Sabril Patient Registry Completed NCT01073579 Sabril®
16 Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism Completed NCT00001489

Search NIH Clinical Center for Complex Partial Epilepsy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: epilepsy, complex partial

Genetic Tests for Complex Partial Epilepsy

Anatomical Context for Complex Partial Epilepsy

MalaCards organs/tissues related to Complex Partial Epilepsy:

42
Brain, Temporal Lobe, Occipital Lobe, Parietal Lobe, Testes, Cortex

Publications for Complex Partial Epilepsy

Articles related to Complex Partial Epilepsy:

(show top 50) (show all 56)
# Title Authors Year
1
A Comparison of Vagal Nerve Stimulation and Responsive Neurostimulation for the Treatment of Medically Refractory Complex Partial Epilepsy. ( 30149389 )
2018
2
Complex Partial Epilepsy Associated with Temporal Lobe Developmental Venous Anomaly. ( 26060525 )
2015
3
Emergence of complex partial epilepsy-like experiences following closed head injuries: personality variables and neuropsychological profiles. ( 22206825 )
2012
4
Features of a subset of children with complex partial epilepsy requiring combination therapy for effective seizure control. ( 19494358 )
2010
5
Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy. ( 19470965 )
2009
6
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation. ( 18413482 )
2008
7
Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. ( 18509280 )
2008
8
Re: Atypical language in lesional and nonlesional complex partial epilepsy. ( 18519879 )
2008
9
Atypical language in lesional and nonlesional complex partial epilepsy. ( 17967992 )
2007
10
Effect of vagal nerve stimulation in a case of Tourette's syndrome and complex partial epilepsy. ( 16703589 )
2006
11
Early antiepileptic drug reduction following anterior temporal lobectomy for medically intractable complex partial epilepsy. ( 15276148 )
2004
12
Intelligence functions disorders in patients with complex partial epilepsy. ( 15608956 )
2004
13
Attentional disorders in patients with complex partial epilepsy. ( 12894263 )
2003
14
Pharyngeal dysesthesia in refractory complex partial epilepsy: new seizure or adverse effect of vagal nerve stimulation? ( 12790902 )
2003
15
A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy. ( 11906955 )
2002
16
Alfentanil-induced epileptiform activity: a simultaneous surface and depth electroencephalographic study in complex partial epilepsy. ( 11240593 )
2001
17
Synchronized feeding as a &amp;quot;conditioned stimulus&amp;quot; for overt seizures in chronically (limbic) epileptic rats: a model for &amp;quot;psychogenic seizures&amp;quot; with complex partial epilepsy. ( 11264918 )
2001
18
A neurobehavioral approach for treatment of complex partial epilepsy: efficacy. ( 10775516 )
2000
19
Experience of a 3-D, Large-Field-Of-View (LFOV) PET Scanner for the Localization Of Complex Partial Epilepsy. ( 14516625 )
1999
20
Disturbances of amino acids from temporal lobe synaptosomes in human complex partial epilepsy. ( 10555778 )
1999
21
Cost-effectiveness of anterotemporal lobectomy in medically intractable complex partial epilepsy. ( 9048666 )
1997
22
Formal thought disorder and psychopathology in pediatric primary generalized and complex partial epilepsy. ( 9291731 )
1997
23
Sex differences in cerebral language dominance in complex-partial epilepsy. ( 9112241 )
1997
24
Efficacy of the Continuous Visual Memory Test in lateralizing temporal lobe dysfunction in chronic complex-partial epilepsy. ( 8941859 )
1996
25
Tourette syndrome and complex partial epilepsy--a case report. ( 8753147 )
1996
26
Combined study of 99mTc-HMPAO SPECT and computerized electroencephalographic topography (CET) in patients with medically refractory complex partial epilepsy. ( 8814713 )
1996
27
MFT in complex partial epilepsy: spatio-temporal estimates of interictal activity. ( 8742407 )
1995
28
Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with complex partial epilepsy. ( 7477979 )
1995
29
S.P.E.C.T., E.E.G. and M.R.I. investigations in complex partial epilepsy. ( 7709796 )
1994
30
Catatonia associated with depression secondary to complex partial epilepsy. ( 8444828 )
1993
31
Herpes simplex encephalitis in a patient with complex partial epilepsy: confirmation by the polymerase chain reaction with necropsy studies. ( 8350121 )
1993
32
Language and memory in children with combined complex-partial epilepsy and reading disorder. ( 8323126 )
1993
33
Visual half-field testing of memory functions in patients considered for surgical treatment of intractable complex partial epilepsy. ( 1481638 )
1992
34
Auditory/verbal and visual/spatial memory in children with complex partial epilepsy of temporal lobe origin. ( 1449761 )
1992
35
Fentanyl-induced electrocorticographic seizures in patients with complex partial epilepsy. ( 1625007 )
1992
36
Memory effects following carbamazepine monotherapy in patients with complex partial epilepsy. ( 1344773 )
1992
37
EEG dipole modeling in complex partial epilepsy. ( 1793685 )
1991
38
The critical evaluation of the late results after temporal lobectomy performed because of medically refractory complex partial epilepsy (CPE). ( 2087894 )
1990
39
Spike voltage topography and equivalent dipole localization in complex partial epilepsy. ( 2094309 )
1990
40
Detection of epileptiform activity by different noninvasive EEG methods in complex partial epilepsy. ( 2327741 )
1990
41
Complex partial epilepsy: the role of neuroimaging in localizing a seizure focus for surgical intervention. ( 2230998 )
1990
42
Excitotoxic amino acid receptors in human complex partial epilepsy. ( 1964242 )
1990
43
Temporal intermittent rhythmic delta activity (TIRDA) in the diagnosis of complex partial epilepsy: sensitivity, specificity and predictive value. ( 2804800 )
1989
44
Barbiturate effects on EEG abnormality in complex partial epilepsy. ( 2915222 )
1989
45
Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy. ( 3143561 )
1988
46
Somatostatin-like immunoreactivity in cerebrospinal fluid of patients with complex partial epilepsy. ( 3366146 )
1988
47
The magnetic field of epileptic spikes agrees with intracranial localizations in complex partial epilepsy. ( 3362376 )
1988
48
Effect of gamma-vinyl GABA treatment on cholinergic and aminergic neurotransmission and on cyclic nucleotides in human complex partial epilepsy--a CSF study. ( 2452456 )
1988
49
Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations. ( 3683877 )
1987
50
Somatostatin, beta-endorphin, and prolactin levels in human cerebrospinal fluid during the gamma-vinyl-GABA treatment of patients with complex partial epilepsy. ( 2885776 )
1987

Variations for Complex Partial Epilepsy

Expression for Complex Partial Epilepsy

Search GEO for disease gene expression data for Complex Partial Epilepsy.

Pathways for Complex Partial Epilepsy

GO Terms for Complex Partial Epilepsy

Cellular components related to Complex Partial Epilepsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perikaryon GO:0043204 9.26 OPRM1 ROGDI
2 sarcolemma GO:0042383 8.96 KCND3 OPRM1
3 presynapse GO:0098793 8.85 CLN8
4 dendrite GO:0030425 8.8 KCND3 OPRM1 ROGDI

Sources for Complex Partial Epilepsy

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34 ICD10
35 ICD10 via Orphanet
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37 IUPHAR
38 KEGG
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63 PubMed
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70 SNOMED-CT via HPO
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75 UMLS via Orphanet
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