MCID: CMP010
MIFTS: 57

Complex Regional Pain Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Complex Regional Pain Syndrome

MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 76 53 54 43 15
Complex Regional Pain Syndromes 12 55 44 73
Reflex Sympathetic Dystrophy 53 73
Crps 53

Classifications:



External Ids:

Disease Ontology 12 DOID:3223
MeSH 44 D020918
SNOMED-CT 68 128200000
UMLS 73 C0458219

Summaries for Complex Regional Pain Syndrome

NINDS : 54 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and paine syndrome, and has symptoms including back pain, headache and neuralgia. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Lidocaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related phenotype is integument.

NIH Rare Diseases : 53 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is often not known. Two classifications of CRPS have been recognized based on causalgia. Type I (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and Type II, in which peripheral nerve injury is present. Treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy; and/or a sympathetic nerve block.

MedlinePlus : 43 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally it goes away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD) or... more...

Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 34.1 CALCA NPY
2 paine syndrome 31.8 IL1B SCN9A TAC1
3 burns 30.8 IL1B TNF
4 choroiditis 30.6 IL10 TNF
5 carpal tunnel syndrome 30.3 IL1B IL6 TAC1
6 spondylitis 30.3 HLA-B IL6 TNF
7 somatoform disorder 30.0 IL1B SCN9A TAC1
8 crohn's disease 29.7 IL10 IL1B IL6 TNF
9 psoriatic arthritis 29.7 HLA-B IL1B IL6 TNF
10 major depressive disorder 29.5 IL1B IL6 NPY TNF
11 autoimmune disease 29.2 HLA-B IL10 IL1B IL6 TNF
12 pulmonary disease, chronic obstructive 29.1 CCL2 IL6 TNF
13 arthritis 28.8 CCL2 IL10 IL1B IL6 TNF
14 causalgia 12.0
15 algoneurodystrophy 11.3
16 thoracic outlet syndrome 11.2
17 scorpion envenomation 10.9 IL6 TNF
18 punctate inner choroidopathy 10.9 IL10 TNF
19 leukomalacia 10.9 IL6 TNF
20 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
21 autonomic nervous system disease 10.9
22 peripheral nervous system disease 10.9
23 tropical endomyocardial fibrosis 10.9 IL10 TNF
24 bullous impetigo 10.9 CALCA IL6
25 critical limb ischemia 10.9 IL6 TNF
26 streptococcal toxic-shock syndrome 10.8 IL6 TNF
27 null-cell leukemia 10.8 IL6 TNF
28 eye lymphoma 10.8 IL10 IL6
29 multifocal choroiditis 10.8 IL10 TNF
30 tungiasis 10.8 IL10 TNF
31 retinitis pigmentosa 55 10.8 IL6 TNF
32 acute transverse myelitis 10.8 IL10 IL6
33 endomyocardial fibrosis 10.8 IL10 TNF
34 transient hypogammaglobulinemia 10.8 IL10 TNF
35 anca-associated vasculitis 10.8 IL6 TNF
36 recurrent corneal erosion 10.8 IL1B IL6
37 bagassosis 10.8 IL1B IL6
38 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
39 staphylococcal toxic shock syndrome 10.7 IL1B TNF
40 burn scar 10.7 CALCA TAC1
41 autoimmune myocarditis 10.7 IL1B TNF
42 periodontitis, chronic 10.7 IL1B IL6
43 kashin-beck disease 10.7 IL1B TNF
44 leprosy 2 10.7 CALCA NPY
45 vulvar vestibulitis syndrome 10.7 IL1B TNF
46 idiopathic achalasia 10.7 IL10 TNF
47 type i 10.7
48 trichuriasis 10.7 IL10 TNF
49 uremic pruritus 10.7 IL1B IL6
50 listeriosis 10.6 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to Complex Regional Pain Syndrome

Symptoms & Phenotypes for Complex Regional Pain Syndrome

UMLS symptoms related to Complex Regional Pain Syndrome:


back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 IL10 IL1B IL6 MME SCN9A TAC1

Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
4
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
5
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
6
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
7
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 5785 54670067
8
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
9 Antioxidants Phase 4,Phase 3,Not Applicable
10 Micronutrients Phase 4,Phase 3,Not Applicable
11 Protective Agents Phase 4,Phase 3,Not Applicable
12 Trace Elements Phase 4,Phase 3,Not Applicable
13 Vitamins Phase 4,Phase 3,Not Applicable
14 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
16 Anesthetics, Local Phase 4,Phase 3,Not Applicable
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
18 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
21 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
22 triamcinolone acetonide Phase 4,Phase 3
23 Triamcinolone diacetate Phase 4,Phase 3
24 Triamcinolone hexacetonide Phase 4,Phase 3
25 Anti-Anxiety Agents Phase 4,Phase 2,Not Applicable
26 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
27 Anticonvulsants Phase 4,Phase 2,Not Applicable
28 Antimanic Agents Phase 4,Not Applicable
29 Antiparkinson Agents Phase 4,Not Applicable
30 calcium channel blockers Phase 4,Phase 2,Not Applicable
31 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
32 Diuretics, Potassium Sparing Phase 4,Not Applicable
33 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Not Applicable
34 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
35 GABA Agents Phase 4,Not Applicable
36 Sodium Channel Blockers Phase 4,Not Applicable
37 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
38 calcitonin Phase 4
39 Vasodilator Agents Phase 4,Phase 2
40
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 71273 175805
41
Levobupivacaine Approved, Investigational Phase 3,Not Applicable 27262-47-1 92253
42
Zoledronic acid Approved Phase 3,Phase 2 118072-93-8 68740
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3,Not Applicable 437-38-7 3345
44
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
45
Hydrocodone Approved, Illicit Phase 3 125-29-1 5284569
46
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
47
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
48 Antibodies Phase 3
49 gamma-Globulins Phase 3
50 Immunoglobulins Phase 3

Interventional clinical trials:

(show top 50) (show all 128)
# Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
6 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
7 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
8 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
9 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
10 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
11 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
12 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
13 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
14 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
15 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
16 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
17 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
18 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
19 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
20 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
21 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
22 Efficacy and Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT03530345 Phase 3 Neridronic acid;Placebo
23 Safety of Intravenous Neridronic Acid in CRPS Active, not recruiting NCT02972359 Phase 3 Neridronic acid
24 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
25 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
26 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
27 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
28 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
29 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
30 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
31 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
32 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
33 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
34 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
35 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
36 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
37 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
38 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
39 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
40 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
41 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
42 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
43 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
44 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329 Not Applicable
45 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 Not Applicable placebo
46 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715 Not Applicable
47 Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes Unknown status NCT02742376 Not Applicable
48 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783 Not Applicable
49 Structural and Functional Nerve Changes Following Immobilisation After Distal Radius Fracture - a Pilot Study (NRP) Unknown status NCT02396277
50 Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block Unknown status NCT02737527 Not Applicable 10 ml of 0.25% levobupivacaine injection for LSB

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: complex regional pain syndromes

Genetic Tests for Complex Regional Pain Syndrome

Anatomical Context for Complex Regional Pain Syndrome

MalaCards organs/tissues related to Complex Regional Pain Syndrome:

41
Skin, Spinal Cord, Bone, Testes, Cortex, Dorsal Root Ganglion, Heart

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 810)
# Title Authors Year
1
Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome. ( 29980635 )
2018
2
Signs and Symptoms in 1043 Patients with Complex Regional Pain Syndrome (CRPS). ( 29409933 )
2018
3
Topical Ketamine in the Treatment of Complex Regional Pain Syndrome. ( 29877864 )
2018
4
Fear of movement modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): A single-case study. ( 29317053 )
2018
5
Correlates and importance of neglect-like symptoms in Complex Regional Pain Syndrome. ( 29419655 )
2018
6
Mycophenolate for persistent complex regional pain syndrome, a parallel, open, randomised, proof of concept trial. ( 29794285 )
2018
7
The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis. ( 29404715 )
2018
8
Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology. ( 29794269 )
2018
9
Complex Regional Pain Syndrome Type 1: Diagnosis and Management. ( 29409405 )
2018
10
Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia. ( 29419627 )
2018
11
Long-term Outcomes Using Intrathecal Drug Delivery Systems in Complex Regional Pain Syndrome. ( 29889241 )
2018
12
The Legal Doctrine on the Liability of Physicians in Medical Malpractice Lawsuits Involving Complex Regional Pain Syndrome. ( 29441736 )
2018
13
Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study. ( 29336203 )
2018
14
Spinal cord stimulation in the treatment of complex regional pain syndrome type 1: Is trial truly required? ( 29913360 )
2018
15
Complex Regional Pain Syndrome, Current Concepts and Treatment Options. ( 29404787 )
2018
16
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
2018
17
Complex regional pain syndrome. ( 29858146 )
2018
18
Do we have to rethink Complex Regional Pain Syndrome? ( 29935746 )
2018
19
Utilization of manual therapy to the lumbar spine in conjunction with traditional conservative care for individuals with bilateral lower extremity complex regional pain syndrome: A case series. ( 29873592 )
2018
20
Complex regional pain syndrome of the face in a child. ( 29797456 )
2018
21
Hemi-sensory disturbances in patients with complex regional pain syndrome. ( 29787471 )
2018
22
Utility of Radionuclide Bone Scintigraphy in Complex Regional Pain Syndrome. ( 29388057 )
2018
23
Pain Exposure Physical Therapy versus conventional treatment in complex regional pain syndrome type 1-a cost-effectiveness analysis alongside a randomized controlled trial. ( 29430970 )
2018
24
Vascular Changes of Complex Regional Pain Syndrome Unmask Buerger's Disease (Thromboangiitis Obliterans): A Letter to the Editor. ( 29800280 )
2018
25
Kinesiophobia after complex regional pain syndrome type one in a case of stroke hemiplegia and effect of cognitive behavior therapy. ( 29736085 )
2018
26
Dermal Nerve Fibre and Mast Cell Density, and Proximity of Mast Cells to Nerve Fibres in the Skin of Patients with Complex Regional Pain Syndrome. ( 29905655 )
2018
27
Complex Regional Pain Syndrome after Total Knee Arthroplasty is Rare and Misdiagnosis Potentially Hazardous-Prospective Study of the New Diagnostic Criteria in 100 Patients with No Cases Identified. ( 29294499 )
2018
28
Epidemiology of complex regional pain syndrome in Korea: An electronic population health data study. ( 29864152 )
2018
29
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. ( 29768371 )
2018
30
Extrapyramidal signs occurring after sympathetic block for complex regional pain syndrome responding to diphenhydramine: Two case reports. ( 29953015 )
2018
31
Abstracts from Proceedings Cork CRPS 2017: IASP Special Interest Group in Complex Regional Pain Syndrome (CRPS). ( 29430563 )
2018
32
Complex regional pain syndrome type 1 in the medico-legal setting: High rates of somatoform disorders, opiate use and diagnostic uncertainty. ( 29865933 )
2018
33
Three cases of type-1 complex regional pain syndrome after elective total hip replacement. ( 28862131 )
2017
34
Pain, Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, RSD, CRPS) ( 28613470 )
2017
35
The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture. ( 28691512 )
2017
36
Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis. ( 28774452 )
2017
37
The risk of pain syndrome affecting a previously non-painful limb following trauma or surgery in patients with a history of complex regional pain syndrome. ( 28850441 )
2017
38
Autonomic components of Complex Regional Pain Syndrome (CRPS) are favourably affected by Electrical Twitch-Obtaining Intramuscular Stimulation (ETOIMS): effects on blood pressure and heart rate. ( 29445517 )
2017
39
Perioperative Management of a Parturient with Complex Regional Pain Syndrome for Elective C-Section. ( 29303238 )
2017
40
Complex Regional Pain Syndrome Type I, a Debilitating and Poorly Understood Syndrome. Possible Role for Pulsed Electromagnetic Fields: A Narrative Review. ( 28934787 )
2017
41
Mirror-therapy: An important tool in the management of Complex Regional Pain Syndrome (CRPS). ( 29913641 )
2017
42
Including Parents in the Treatment of Pediatric Complex Regional Pain Syndrome. ( 29406662 )
2017
43
Hand lesion after arthroscopic rotator cuff repair: Association with complex regional pain syndrome. ( 28947243 )
2017
44
Passive transfer autoimmunity in a mouse model of complex regional pain syndrome. ( 28891866 )
2017
45
Qualitative pain research emphasizes that patients need true information and physicians and nurses need more knowledge of complex regional pain syndrome (CRPS). ( 28850331 )
2017
46
Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I). ( 28914784 )
2017
47
Effects of Simvastatin Beyond Dyslipidemia: Exploring Its Antinociceptive Action in an Animal Model of Complex Regional Pain Syndrome-Type I. ( 28928655 )
2017
48
Special indications for Opioid Free Anaesthesia and Analgesia, patient and procedure related: Including obesity, sleep apnoea, chronic obstructive pulmonary disease, complex regional pain syndromes, opioid addiction and cancer surgery. ( 29739543 )
2017
49
Neurogenic Edema from Complex Regional Pain Syndrome Resulting in Fulminant Infection Necessitating Below Elbow Amputation. ( 29302140 )
2017
50
Complex regional pain syndrome: medical and legal ramifications of clinical variability and experience and perspective of a practicing clinician. ( 28031726 )
2017

Variations for Complex Regional Pain Syndrome

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 CCL2 HLA-B IL10 IL1B IL6 TNF
2
Show member pathways
12.93 CCL2 IL10 IL1B IL6 TNF
3
Show member pathways
12.82 HLA-B IL10 IL1B IL6 TNF
4
Show member pathways
12.74 CCL2 HLA-B IL1B IL6 TNF
5
Show member pathways
12.57 HLA-B IL10 IL1B IL6 TNF
6
Show member pathways
12.54 CCL2 IL10 IL1B IL6 TNF
7 12.52 CALCA NPY SCN9A TOR1A
8 12.5 CCL2 IL10 IL1B TNF
9
Show member pathways
12.4 IL10 IL1B IL6 TNF
10
Show member pathways
12.38 IL10 IL1B IL6 TNF
11
Show member pathways
12.3 CCL2 IL1B IL6 TNF
12
Show member pathways
12.29 CCL2 IL1B IL6 TNF
13
Show member pathways
12.22 IL10 IL1B IL6 TNF
14 12.19 IL10 IL1B IL6 TNF
15
Show member pathways
12.18 EDN1 IL1B IL6 TNF
16
Show member pathways
12.17 IL10 IL1B IL6 TNF
17 12.12 IL10 IL1B IL6 TAC1 TNF
18 12.06 CCL2 EDN1 IL1B TNF
19
Show member pathways
12.01 CCL2 IL10 IL1B IL6
20 11.97 CCL2 IL1B IL6 TNF
21 11.95 IL10 IL6 MME TNF
22 11.89 CCL2 IL10 IL1B IL6 TNF
23 11.85 IL1B IL6 MME TNF
24 11.84 IL10 IL1B IL6 TNF
25 11.84 CCL2 EDN1 IL1B IL6 TNF
26 11.8 CCL2 IL1B IL6 TNF
27 11.75 IL10 IL1B TNF
28 11.72 CCL2 EDN1 IL1B IL6 TNF
29 11.71 IL10 IL1B IL6 TNF
30
Show member pathways
11.64 IL1B IL6 TNF
31 11.57 IL1B IL6 TNF
32 11.52 IL10 IL1B IL6 MME TNF
33 11.5 CCL2 IL1B TNF
34 11.45 CALCA IL1B IL6 TNF
35 11.33 CALCA EDN1 NPY
36 11.32 IL10 IL1B IL6 TNF
37 11.3 IL10 IL1B IL6 TNF
38 11.29 IL1B IL6 TNF
39 11.27 IL1B IL6 TNF
40 11.24 CCL2 IL10 IL1B IL6 TNF
41 11.15 IL10 IL1B IL6 TNF
42 11.04 IL1B TNF
43 11.04 IL6 TNF
44 11.04 CCL2 IL10 IL1B IL6 TNF
45 10.97 IL6 TNF
46 10.92 CCL2 IL1B TNF
47 10.9 CALCA CCL2 EDN1 IL1B IL6 TNF

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA CCL2 EDN1 IL10 IL1B IL6
2 extracellular space GO:0005615 9.28 CALCA CCL2 EDN1 IL10 IL1B IL6

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.89 EDN1 IL10 IL1B TAC1
2 cell-cell signaling GO:0007267 9.88 CALCA EDN1 IL1B NPY TAC1
3 immune response GO:0006955 9.88 CCL2 HLA-B IL10 IL1B IL6 TNF
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.87 CALCA EDN1 TAC1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B IL6 TNF
6 neuron projection development GO:0031175 9.87 IL6 NPY TOR1A
7 cellular response to tumor necrosis factor GO:0071356 9.86 CALCA CCL2 EDN1
8 cytokine-mediated signaling pathway GO:0019221 9.85 CCL2 IL10 IL1B IL6 TNF
9 neuropeptide signaling pathway GO:0007218 9.84 CALCA NPY TAC1
10 cellular response to organic cyclic compound GO:0071407 9.82 CCL2 IL1B TNF
11 cellular response to lipopolysaccharide GO:0071222 9.81 CCL2 IL10 IL6 TNF
12 neutrophil chemotaxis GO:0030593 9.8 CCL2 EDN1 IL1B
13 response to glucocorticoid GO:0051384 9.8 IL10 IL6 TNF
14 humoral immune response GO:0006959 9.79 CCL2 IL6 TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 EDN1 IL6 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.76 IL1B IL6 TNF
17 protein kinase B signaling GO:0043491 9.74 CCL2 IL1B TNF
18 monocyte chemotaxis GO:0002548 9.73 CALCA CCL2 IL6
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 EDN1 IL1B TNF
20 response to pain GO:0048265 9.69 CALCA TAC1
21 positive regulation of chemokine production GO:0032722 9.69 IL6 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
24 positive regulation of ossification GO:0045778 9.68 CALCA TAC1
25 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 TNF
26 positive regulation of renal sodium excretion GO:0035815 9.67 EDN1 TAC1
27 negative regulation of bone resorption GO:0045779 9.67 CALCA IL6
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TNF
29 regulation of blood pressure GO:0008217 9.67 CALCA EDN1 NPY TAC1
30 positive regulation of acute inflammatory response GO:0002675 9.66 IL6 TAC1
31 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
33 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
34 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
35 positive regulation of prostaglandin secretion GO:0032308 9.63 EDN1 IL1B
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
37 positive regulation of interleukin-8 production GO:0032757 9.61 CALCA IL1B TNF
38 positive regulation of fever generation GO:0031622 9.6 IL1B TNF
39 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
40 sensory perception of pain GO:0019233 9.56 EDN1 MME SCN9A TAC1
41 regulation of signaling receptor activity GO:0010469 9.56 CALCA CCL2 EDN1 IL10 IL1B IL6
42 positive regulation of DNA binding transcription factor activity GO:0051091 9.55 EDN1 IL10 IL1B IL6 TNF
43 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IL1B TNF
45 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
46 inflammatory response GO:0006954 9.23 CALCA CCL2 IL10 IL1B IL6 SCN9A

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.43 CALCA CCL2 EDN1 HLA-B NPY TAC1
2 hormone activity GO:0005179 9.33 CALCA EDN1 NPY
3 cytokine activity GO:0005125 9.1 CCL2 EDN1 IL10 IL1B IL6 TNF

Sources for Complex Regional Pain Syndrome

3 CDC
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10 dbSNP
11 DGIdb
17 ExPASy
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69 SNOMED-CT via HPO
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72 Tocris
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74 UMLS via Orphanet
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