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CRPS
MCID: CMP010
MIFTS: 58

Complex Regional Pain Syndrome (CRPS)

Categories: Neuronal diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Complex Regional Pain Syndrome

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MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 74 52 53 42 15 17
Complex Regional Pain Syndromes 12 54 43 71
Reflex Sympathetic Dystrophy 52 71
Crps 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3223
MeSH 43 D020918
UMLS 71 C0034931 C0458219
Sources

Summaries for Complex Regional Pain Syndrome

About this section
NINDS : 53 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and causalgia, and has symptoms including seizures, tremor and back pain. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Ketamine and Morphine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and bone, and related phenotypes are limb pain and dry skin

NIH Rare Diseases : 52 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is often not known. Two classifications of CRPS have been recognized based on causalgia. Type I (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and Type II, in which peripheral nerve injury is present. Treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy ; and/or a sympathetic nerve block .

MedlinePlus : 42 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally the symptoms go away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), describes an... more...

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Related Diseases for Complex Regional Pain Syndrome

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Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1062)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 34.1 TAC1 NPY CALCA ADRA1A
2 causalgia 34.1 TACR1 TAC1 CALCA ADRA1A
3 adult-onset still's disease 32.2 TNF IL6 IL1B CXCL8
4 autonomic nervous system disease 31.6 TACR1 TAC1 SCN9A NPY IL6 CALCA
5 paine syndrome 31.3 TACR1 TAC1 SCN9A CALCA
6 hemiplegia 31.0 TAC1 EDN1 CALCA
7 periodontitis, chronic 31.0 IL6 IL1B
8 arteries, anomalies of 30.9 TNF IL6 EDN1 CCL2
9 herpes zoster 30.8 TNF IL2 IL10
10 bone resorption disease 30.8 TNF IL6 CALCA
11 temporal arteritis 30.7 TNF IL6 CCL2
12 vulvar vestibulitis syndrome 30.7 TNF IL1B
13 haemophilus influenzae 30.7 TNF CXCL8
14 spondylitis 30.7 TNF IL6 IL10
15 typhoid fever 30.7 TNF IL6 IL1B
16 plague 30.6 TNF IL6 IL10
17 neuroma 30.6 IL6 GFAP CALCA
18 chickenpox 30.6 TNF IL6 IL2 IL10
19 fatty liver disease 30.6 TNF IL6 IL1B CXCL8
20 polyneuropathy 30.6 TNF IL6 IL1B CALCA
21 arteriovenous malformation 30.6 TNF IL6 EDN1
22 carpal tunnel syndrome 30.5 TAC1 IL6 IL2 IL1B CCL2
23 familial mediterranean fever 30.5 TNF IL6 IL1B IL10
24 traumatic brain injury 30.5 IL6 IL10 GFAP
25 acute pancreatitis 30.5 TNF IL6 IL1B IL10 CXCL8
26 prosthetic joint infection 30.5 IL6 IL1B
27 rubella 30.5 TNF IL6 IL2 IL10
28 chlamydia pneumonia 30.4 TNF IL6 IL10 CXCL8
29 bacterial infectious disease 30.4 TNF IL6 IL1B IL10 CXCL8 CCL2
30 apnea, obstructive sleep 30.4 TNF IL6 EDN1 CXCL8
31 spinal cord injury 30.4 TNF IL6 GFAP CXCL8
32 allergic hypersensitivity disease 30.4 TNF IL2 IL10 CXCL8
33 radiculopathy 30.4 TAC1 IL6 IL10 CXCL8 CCL2
34 periodontitis 30.4 TNF IL6 IL1B IL10 CXCL8 CCL2
35 atherosclerosis susceptibility 30.4 TNF IL6 IL1B EDN1 CXCL8 CCL2
36 myofascial pain syndrome 30.4 TAC1 POMC CALCA
37 cryoglobulinemia 30.4 TNF IL6 IL10
38 peptic ulcer disease 30.4 TNF IL1B IL10 CXCL8
39 salmonellosis 30.4 TNF IL6 IL1B IL10
40 lyme disease 30.4 TNF IL6 IL1B
41 end stage renal failure 30.4 TNF IL6 IL2 CALCA
42 leptin deficiency or dysfunction 30.4 TNF POMC NPY IL6
43 non-alcoholic steatohepatitis 30.3 TNF IL6
44 tetanus 30.3 TNF IL6 IL2 IL1B IL10
45 purpura 30.3 TNF IL6 IL10
46 acute graft versus host disease 30.3 TNF IL2 IL10
47 non-alcoholic fatty liver disease 30.3 TNF IL6 IL1B IL10 CXCL8
48 coronary artery anomaly 30.3 TNF IL6 IL1B IL10 EDN1 CXCL8
49 arteriosclerosis 30.3 IL6 IL10 EDN1 CCL2
50 pulmonary tuberculosis 30.3 TNF IL6 IL2 IL10 CCL2

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to Complex Regional Pain Syndrome
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Symptoms & Phenotypes for Complex Regional Pain Syndrome

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Human phenotypes related to Complex Regional Pain Syndrome:

31 (show all 11)
# Description HPO Frequency HPO Source Accession
1 limb pain 31 hallmark (90%) HP:0009763
2 dry skin 31 frequent (33%) HP:0000958
3 erythema 31 frequent (33%) HP:0010783
4 involuntary movements 31 frequent (33%) HP:0004305
5 allodynia 31 frequent (33%) HP:0012533
6 slow-growing nails 31 frequent (33%) HP:0008383
7 hyperalgesia 31 frequent (33%) HP:0031005
8 edema of the upper limbs 31 frequent (33%) HP:0010742
9 trophic changes related to pain 31 frequent (33%) HP:0010834
10 abnormality of hair growth 31 frequent (33%) HP:0040170
11 pedal edema 31 frequent (33%) HP:0010741

UMLS symptoms related to Complex Regional Pain Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ADRA1A ADRB2 GFAP IL10 IL2 IL6
2 homeostasis/metabolism MP:0005376 10.2 ADRA1A ADRB2 EDN1 GCH1 GFAP IL10
3 cardiovascular system MP:0005385 10.18 ADRA1A ADRB2 EDN1 GCH1 GFAP IL10
4 immune system MP:0005387 10.03 ADRB2 CCL2 GFAP IL10 IL1B IL2
5 integument MP:0010771 9.81 IL10 IL1B IL6 MME POMC SCN9A
6 muscle MP:0005369 9.56 ADRA1A ADRB2 EDN1 GFAP IL10 IL6
7 nervous system MP:0003631 9.47 ADRB2 EDN1 GCH1 GFAP IL10 IL1B
Sources

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Memantine Approved, Investigational Phase 4 19982-08-2 4054
5
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
6
Clozapine Approved Phase 4 5786-21-0 2818
7
Capsaicin Approved Phase 4 404-86-4 1548943
8
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
9
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
10
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
11
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
12 Analgesics, Opioid Phase 4
13 Micronutrients Phase 4
14 Trace Elements Phase 4
15 Antioxidants Phase 4
16 Nutrients Phase 4
17 Vitamins Phase 4
18 Protective Agents Phase 4
19 Neurotransmitter Agents Phase 4
20 Antimanic Agents Phase 4
21 Excitatory Amino Acid Antagonists Phase 4
22 Excitatory Amino Acids Phase 4
23 Anesthetics, Dissociative Phase 4
24 Anesthetics, General Phase 4
25 Anesthetics, Intravenous Phase 4
26 Anti-Infective Agents Phase 4
27 Dopamine Agents Phase 4
28 Antiparkinson Agents Phase 4
29 Antipsychotic Agents Phase 4
30 GABA Agents Phase 4
31 Serotonin Agents Phase 4
32 Anti-Bacterial Agents Phase 4
33 Serotonin Antagonists Phase 4
34 Antipruritics Phase 4
35 Dermatologic Agents Phase 4
36 Anticonvulsants Phase 4
37 Anti-Anxiety Agents Phase 4
38 Tranquilizing Agents Phase 4
39 Psychotropic Drugs Phase 4
40 calcium channel blockers Phase 4
41 Calcium, Dietary Phase 4
42
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
43
Levobupivacaine Approved, Investigational Phase 3 27262-47-1 92253
44
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
45
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
46
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
47
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
48
Sodium citrate Approved, Investigational Phase 3 68-04-2
49
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
50
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516

Interventional clinical trials:

(show top 50) (show all 189)
# Name Status NCT ID Phase Drugs
1 The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
4 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 Assessing the Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome - a Feasibility Study Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
6 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
7 Bupivacaine Versus Lidocaine Local Anesthesia in Elective Outpatient Hand Surgery: A Randomized Controlled Trial Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
8 Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome Completed NCT02467556 Phase 4 Morphine, memantine
9 The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial Completed NCT00620828 Phase 4 Ropivicaine 0.5%
10 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
11 A Pilot Study of Minocycline Augmentation to Clozapine in Individuals With Treatment Resistant Schizophrenia Completed NCT02124811 Phase 4 Minocycline
12 Safety, Efficacy and Patient Acceptability of Topical Treatment Versus Systemic Treatment: a Randomized, Multicentre, Comparative Pragmatic Trial in Adult Patients Suffering From Diverse Localized Neuropathic Pain (LNP) Syndromes Recruiting NCT03348735 Phase 4 Lidocaine patch 5%;Capsaicin 8% Patch;Pregabalin
13 Does Stellate Ganglion Blockade (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes? A Pilot Prospective Cohort Study Recruiting NCT03796195 Phase 4 .5% Bupivacaine
14 Effectiveness 0f Sympathetic Plexus Block on Male Pelvic Pain (Prostatitis, Prostatodynia) Suspended NCT00194636 Phase 4
15 Prospective, Double-blind, Randomised, Placebo-controlled, Cross-over Study to Investigate the Effect of Intravenous Immunoglobulins on Complex Regional Pain Syndrome (CRPS, M. Sudeck) Unknown status NCT00949065 Phase 3
16 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
17 An Analysis of Photoplethysmographic Signal in Diagnostic Lumbar Sympathetic Block for Complex Regional Pain Syndrome Unknown status NCT01134289 Phase 3
18 Double-Blind Randomized Controlled Trial: Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
19 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
20 Acupuncture and Traditional Chinese Medicine Combined With Rehabilitation Therapy for Post-stroke Shoulder-hand Syndrome in Community Hospital: a Multicenter，Randomized，Controlled Trial Unknown status NCT02011854 Phase 2, Phase 3
21 Effect on Migraine Frequency of Combined Anti-oxidant Therapy: N-acetylcysteine, Vitamin E and Vitamin C (NEC): The MIGRANT Study Unknown status NCT02629536 Phase 3 N-acetyl cysteine 600 mg, VitE 250 IU, VitC 500 mg tablet
22 Novel Non Invasive Brain Stimulation Based Treatment for Chronic Low Back Unknown status NCT02393391 Phase 2, Phase 3
23 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidamide in the Treatment of Complex Regional Pain Syndrome Type1 Completed NCT00166452 Phase 3 Lenalidamide
24 Open-label Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Completed NCT02972359 Phase 3 Neridronic acid
25 A Randomized, Double-blind Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
26 A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
27 Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I Completed NCT00817128 Phase 2, Phase 3
28 A 12-Week Open-Label Study With 3 Within-Patient Double-Blind Placebo-Controlled Periods to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
29 A 12-Month, Open-Label Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) at 15 to 90 mg Every 12 Hours in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
30 The Effectiveness of Taping Technique Versus Conventional Techniques in Prevention of Shoulder Injuries in Patients With Acute Stroke-A Prospective, Randomized, Interventional, Outcome Blinded (PROBE Design), Parallel Design Trial Completed NCT01062308 Phase 3
31 Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain Completed NCT01872481 Phase 3
32 CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zoledronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
33 A Prospective Randomized Controlled Pilot Study Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Enrolling by invitation NCT03879538 Phase 3 Nitrous Oxide;Oxygen
34 Randomized, Double-blind, Placebo-controlled Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03530345 Phase 3 Neridronic acid;Placebo
35 Placebo-controlled Efficacy and Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03560986 Phase 3 Neridronic acid;Placebo
36 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
37 Phase 2 Study - The Use of a Single 5 mg Dose of Zoledronic Acid in Complex Regional Pain Syndrome Patient. Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
38 Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
39 Treatment Of Chronic Pain Using Real-time Functional MRI Trial Unknown status NCT00528346 Phase 2
40 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) - a Randomized Trial Unknown status NCT01184586 Phase 2
41 A Multicenter, Open-Label Study to Evaluate the Preliminary Safety and Efficacy of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
42 A Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset Complex Regional Pain Syndrome After Total Knee Arthroplasty Completed NCT00558753 Phase 2 pregabalin;Placebo
43 A Randomized, Cross-over, Placebo-controlled, Double-blind, Single-center, Phase II Study of Cetuximab in Patients With Treatment-refractory, Non-malignant Severe Chronic Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
44 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
45 CCRC: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
46 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
47 A Pilot Trial of Intravenous Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
48 3D Augmented Reality Mirror Visual Feedback Therapy Applied to the Treatment of Persistent, Unilateral Upper Extremity Neuropathic Pain: A Preliminary Study Completed NCT02582216 Phase 1, Phase 2
49 Multicentered, Randomized Study of Safety and Efficacy of Whole-body Vibration as add-on to Standard Pharmacological Treatment of Osteoporosis in Post-menopausal Women Completed NCT01415050 Phase 2
50 A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 as an Adjunctive Therapy in Adult Subjects With Chronic Complex Regional Pain Syndrome Recruiting NCT03990649 Phase 2 TAK-935;TAK-935 Placebo

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ethanol

Cochrane evidence based reviews: complex regional pain syndromes

Sources

Genetic Tests for Complex Regional Pain Syndrome

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Sources

Anatomical Context for Complex Regional Pain Syndrome

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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

40
Spinal Cord, Skin, Bone, Brain, Testes, Heart, Cortex
Sources

Publications for Complex Regional Pain Syndrome

About this section

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 2891)
# Title Authors PMID Year
1
Pharmacotherapeutic options for complex regional pain syndrome. 61 42
31063415 2019
2
Complex regional pain syndrome: a narrative review for the practising clinician. 61 42
31056241 2019
3
The Efficacy of Vitamin C in the Prevention of Complex Regional Pain Syndrome After Distal Radius Fractures: A Synthesis. 61 42
30998426 2018
4
A high thoracic erector spinae plane block used for sympathetic block in patients with upper extremity complex regional pain syndrome. 61
31525714 2020
5
Evaluating a sensitive issue: reliability of a clinical evaluation for allodynia severity. 61
31858880 2020
6
Effects of Tonic Spinal Cord Stimulation on External Mechanical and Thermal Stimuli Perception Using Quantitative Sensory Testing: A Multicenter Stimulation ON-OFF Study on Chronic Pain Patients. 61
31833916 2020
7
Influence of vitamin C on the incidence of CRPS-I after subacromial shoulder surgery. 61
31541301 2020
8
A Systematic Literature Review of Spine Neurostimulation Therapies for the Treatment of Pain. 61
32034422 2020
9
Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. 61
31475305 2020
10
Ten-year radiological and clinical outcomes of capitolunate arthrodesis with scaphoid and triquetrum excision for advanced degenerative arthritis in the wrist: Single-center, retrospective case series with 10patients. 61
31683037 2020
11
Percutaneous pinning for treating distal radial fractures in adults. 61
32032439 2020
12
Suboptimal learning of tactile-spatial predictions in patients with complex regional pain syndrome. 61
31651574 2020
13
Complex Regional Pain Syndrome Evolving to Full-Blown Fibromyalgia: A Proposal of Common Mechanisms. 61
32028304 2020
14
Autoantibodies against P29ING4 are associated with complex regional pain syndrome. 61
32008173 2020
15
Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema. 61
30801357 2020
16
Unravelling the Complex Regional Pain Syndrome Enigma. 61
31348512 2020
17
Persons with Complex Regional Pain Syndrome Renegotiate Social Roles and Intimacy: A Qualitative Study. 61
31504892 2020
18
Complex Regional Pain Syndrome Management: An Evaluation of the Risks and Benefits of Spinal Cord Stimulator Use in Pregnancy. 61
31357254 2020
19
Treatment of Distal Radius Fracture: Does Early Activity Postinjury Lead to a Lower Incidence of Complex Regional Pain Syndrome? 61
31916452 2020
20
Perioperative Outcomes of Spinal Cord Stimulator Placement in Patients with Complex Regional Pain Syndrome (CRPS) Compared to Patients Without CRPS. 61
31954908 2020
21
Hazard of complex regional pain syndrome following human papillomavirus vaccination among adolescent girls in the United States: a case-cohort analysis of insurance claims data. 61
31674255 2020
22
Neural substrates for post-stroke complex regional pain syndrome type I: a retrospective case-control study using voxel-based lesion symptom mapping analysis. 61
31985589 2020
23
Electroacupuncture Alleviates Mechanical Allodynia in a Rat Model of Complex Regional Pain Syndrome Type-I via Suppressing Spinal CXCL12/CXCR4 Signaling. 61
32006698 2020
24
Utilization of manual therapy to the lumbar spine in conjunction with traditional conservative care for individuals with bilateral lower extremity complex regional pain syndrome: A case series. 61
29873592 2020
25
Sphingosine 1-phosphate receptor modulation attenuate mechanical allodynia in mouse model of chronic complex regional pain syndrome by suppressing pathogenic astrocyte activation. 61
31969447 2020
26
Fantastic Four: Age, Spinal Cord Stimulator Waveform, Pain Localization and History of Spine Surgery Influence the Odds of Successful Spinal Cord Stimulator Trial. 61
32013285 2020
27
Comparative Study of Chronic Postischemic Pain Models in Mice: O-Ring Versus Tie Method. 61
32013288 2020
28
Labeled substance P as a neuropeptide reporter substance for enzyme activity. 61
31718985 2020
29
Ketamine and Cognitive Behavioral Therapy for Rapid Opioid Tapering With Sustained Opioid Abstinence: A Case Report and 1-Year Follow-up. 61
31408575 2020
30
Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. 61
31928708 2020
31
Thoracolumbar Spinal Cord Stimulator Trial: Procedural Technique. 61
31913169 2020
32
Randomized Placebo-/Sham-Controlled Trials of Spinal Cord Stimulation: A Systematic Review and Methodological Appraisal. 61
31305001 2020
33
Allodynography: Reliability of a New Procedure for Objective Clinical Examination of Static Mechanical Allodynia. 61
30908579 2020
34
Early Versus Late Motion Following Volar Plating of Distal Radius Fractures. 61
30009627 2020
35
The Impact of Tobacco Smoking on Spinal Cord Stimulation Effectiveness in Complex Regional Pain Syndrome Patients. 61
31710411 2020
36
Generalization of exposure in vivo in Complex Regional Pain Syndrome type I. 61
31865235 2020
37
Clinical phenotypes and classification algorithm for complex regional pain syndrome. 61
31874923 2020
38
Segmental complex regional pain syndrome of the thumb. 61
31989278 2020
39
[How to treat complex regional pain syndrome (CRPS)]. 61
31960303 2020
40
Spinal Cord Stimulator Placement in Patient With von Willebrand Disease: A Case Report. 61
31977322 2020
41
Use of Oral Prednisolone and a 3-Phase Bone Scintigraphy in Patients with Complex Regional Pain Syndrome Type I. 61
31936474 2020
42
Complex regional pain syndrome patient immunoglobulin M has pronociceptive effects in the skin and spinal cord of tibia fracture mice. 61
31815913 2020
43
CRPS is not associated with altered sensorimotor cortex GABA or glutamate. 61
31980452 2020
44
Ultrasound-guided Percutaneous Peripheral Nerve Stimulation for the Treatment of Complex Regional Pain Syndrome Type 1 Following a Crush Injury to the Fifth Digit: A Rare Case Report. 61
32025427 2019
45
Disruption of Homeostasis Based on the Right and Left Hemisphere in Patients with Complex Regional Pain Syndrome. 61
31865325 2019
46
[Clinical observation of Jingu three-needle therapy combined with Xingnao Kaiqiao acupuncture on complex regional pain syndrome after stroke]. 61
31820599 2019
47
Topical combination of meldonium and N-acetyl cysteine relieves allodynia in rat models of CRPS-1 and peripheral neuropathic pain by enhancing NO-mediated tissue oxygenation. 61
31853976 2019
48
Arthroscopic treatment of elbow osteoarthritis. 61
31558411 2019
49
Relief of Neuropathic Pain Through Epidermal Growth Factor Receptor Inhibition: A Randomized Proof-of-Concept Trial. 61
31106835 2019
50
Autoantibodies produce pain in complex regional pain syndrome by sensitizing nociceptors. 61
31343542 2019
Sources

Variations for Complex Regional Pain Syndrome

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Expression for Complex Regional Pain Syndrome

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Search GEO for disease gene expression data for Complex Regional Pain Syndrome.
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Pathways for Complex Regional Pain Syndrome

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Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.23 TNF TACR1 TAC1 POMC NPY IL6
2
Peptide ligand-binding receptors 65
Show member pathways
 13.64 TACR1 TAC1 POMC NPY EDN1 CXCL8
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.41 TNF POMC IL6 IL2 IL1B IL10
4
PAK Pathway 63
Show member pathways
 13.34 TNF IL6 IL2 IL1B IL10 CXCL8
5
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.17 TNF IL6 IL2 IL1B IL10 CXCL8
6
Allograft rejection 1 36
Show member pathways
 12.9 TNF IL6 IL2 IL1B IL10 CXCL8
7
Measles 36
Show member pathways
 12.87 TNF IL6 IL2 IL1B CXCL8 CCL2
8
T cell receptor signaling pathway 36
Show member pathways
 12.65 TNF IL6 IL2 IL1B IL10
9
Th17 cell differentiation 36
Show member pathways
 12.65 TNF IL6 IL2 IL1B IL10
10
Immune response IL-23 signaling pathway 22
Show member pathways
 12.64 TNF IL6 IL2 IL1B IL10 CCL2
11
Neuroscience 4
12.63 TOR1A SCN9A POMC NPY GFAP CALCA
12
NF-kappaB Signaling 4
12.62 TNF IL2 IL1B IL10 CCL2
13
Myometrial Relaxation and Contraction Pathways 1
Show member pathways
 12.59 IL6 IL1B CALCA ADRB2 ADRA1A
14
IL-17 Family Signaling Pathways 64
Show member pathways
 12.4 TNF IL6 IL1B CXCL8 CCL2
15
Folate Metabolism 1
Show member pathways
 12.4 TNF IL6 IL2 IL1B CCL2
16
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.39 IL6 IL2 IL10 GFAP
17
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.38 TNF IL6 IL2 IL10 CXCL8 CCL2
18
cAMP signaling pathway 36
12.37 POMC NPY EDN1 ADRB2
19
Pathogenic Escherichia coli infection 36
12.34 TNF IL6 IL1B CXCL8
20
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.32 TNF IL6 IL2 IL1B IL10 CXCL8
21
NOD-like receptor signaling pathway 36
12.31 TNF IL6 IL1B CXCL8 CCL2
22
IL-1 Family Signaling Pathways 64
Show member pathways
 12.29 TNF IL6 IL1B EDN1 CXCL8
23
Tuberculosis 36
12.28 TNF IL6 IL1B IL10
24
C-type lectin receptor signaling pathway 36
Show member pathways
 12.28 TNF IL6 IL2 IL1B IL10
25
Bacterial infections in CF airways 22
Show member pathways
 12.24 TNF IL6 IL1B CXCL8
26
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.23 TNF TACR1 TAC1 IL6 IL1B IL10
27
Fluid shear stress and atherosclerosis 36
12.15 TNF IL1B EDN1 CCL2
28
Th1 Differentiation Pathway 64
Show member pathways
 12.13 TNF IL6 IL2 IL1B IL10
29
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.07 TNF MME IL6 IL2 IL10
30
TNF signaling pathway 36
12.05 TNF IL6 IL1B EDN1 CCL2
31
Yersinia infection 36
11.99 TNF IL6 IL2 IL1B IL10 CXCL8
32
Hematopoietic cell lineage 36
11.98 TNF MME IL6 IL1B
33
Amoebiasis 36
11.98 TNF IL6 IL1B IL10 CXCL8
34
AGE-RAGE signaling pathway in diabetic complications 36
11.97 TNF IL6 IL1B EDN1 CXCL8 CCL2
35
Rheumatoid arthritis 36
11.92 TNF IL6 IL1B CXCL8 CCL2
36
Interleukin-4 and 13 signaling 65
11.92 TNF POMC IL6 IL1B IL10 CXCL8
37
Glucocorticoid receptor regulatory network 1
11.88 POMC IL6 IL2 CXCL8
38
Innate Lymphoid Cell Differentiation Pathways 64
11.86 TNF IL2 IL1B IL10
39
Salmonella infection (KEGG) 36
11.82 IL6 IL1B CXCL8
40
Pertussis 36
11.8 TNF IL6 IL1B IL10 CXCL8
41
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.79 TNF IL2 CXCL8
42
Dendritic Cells Developmental Lineage Pathway 64
11.78 TNF MME IL6 IL2 IL1B IL10
43
Adipocytokine signaling pathway 36
11.75 TNF POMC NPY
44
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.73 TNF IL6 IL2 IL1B IL10 CCL2
45
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.71 TNF IL6 IL2 IL1B CXCL8
46
Legionellosis 36
11.68 TNF IL6 IL1B CXCL8
47
Photodynamic therapy-induced AP-1 survival signaling. 1
11.6 TNF IL6 IL2
48
MSP-RON Signaling 63
11.57 TNF IL1B CCL2
49
Aryl Hydrocarbon Receptor Pathway 1
11.57 TNF IL2 IL1B
50
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.57 TNF IL6 IL1B CALCA
Sources

GO Terms for Complex Regional Pain Syndrome

About this section

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TNF TAC1 POMC NPY IL6 IL2
2 cell GO:0005623 9.65 TOR1A TACR1 TAC1 NPY IL6 IL2
3 extracellular space GO:0005615 9.4 TNF TAC1 POMC NPY IL6 IL2

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 TACR1 POMC IL6 IL1B IL10 CXCL8
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 TNF POMC IL6 IL2 IL1B IL10
3 negative regulation of cell proliferation GO:0008285 10.11 IL6 IL1B IL10 CXCL8 ADRA1A
4 immune response GO:0006955 10.05 TNF IL6 IL2 IL1B IL10 CXCL8
5 G protein-coupled receptor signaling pathway GO:0007186 10 TACR1 TAC1 POMC NPY IL2 EDN1
6 aging GO:0007568 9.98 MME IL10 CALCA ADRA1A
7 cellular response to lipopolysaccharide GO:0071222 9.95 TNF IL6 IL1B IL10 CXCL8 CCL2
8 cellular response to tumor necrosis factor GO:0071356 9.93 EDN1 CXCL8 CCL2 CALCA
9 response to lipopolysaccharide GO:0032496 9.93 TAC1 IL1B IL10 GCH1 EDN1
10 positive regulation of cytosolic calcium ion concentration GO:0007204 9.93 TACR1 TAC1 IL2 EDN1 CALCA ADRA1A
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 TNF IL6 IL2
12 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B CCL2
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 TNF IL6 IL1B IL10 EDN1
14 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10
15 neuropeptide signaling pathway GO:0007218 9.88 TAC1 POMC NPY CALCA
16 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL2 IL1B
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 TNF IL1B EDN1
18 positive regulation of interleukin-6 production GO:0032755 9.87 TNF IL6 IL1B
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF IL6 EDN1
20 cell-cell signaling GO:0007267 9.87 TAC1 POMC IL2 IL1B EDN1 CALCA
21 humoral immune response GO:0006959 9.86 TNF IL6 CCL2
22 neutrophil chemotaxis GO:0030593 9.86 IL1B EDN1 CXCL8 CCL2
23 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.85 TNF IL10 EDN1
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF IL1B EDN1
25 positive regulation of interferon-gamma production GO:0032729 9.83 TNF IL2 IL1B
26 monocyte chemotaxis GO:0002548 9.82 IL6 CCL2 CALCA
27 protein kinase B signaling GO:0043491 9.81 TNF IL1B CCL2
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF IL1B CCL2
29 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10
30 negative regulation of neurogenesis GO:0050768 9.77 TNF IL6 IL1B
31 positive regulation of interleukin-8 production GO:0032757 9.77 TNF IL1B CALCA
32 sensory perception of pain GO:0019233 9.77 TAC1 SCN9A MME EDN1 CCL2
33 cytokine-mediated signaling pathway GO:0019221 9.76 TNF POMC IL6 IL2 IL1B IL10
34 positive regulation of heart rate GO:0010460 9.74 GCH1 EDN1 ADRA1A
35 response to pain GO:0048265 9.73 TACR1 TAC1 GCH1 CALCA
36 positive regulation of chemokine biosynthetic process GO:0045080 9.72 TNF IL1B
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 TNF IL1B IL10
38 negative regulation of lipid storage GO:0010888 9.71 TNF IL6
39 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6 IL1B GFAP
40 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
41 tachykinin receptor signaling pathway GO:0007217 9.7 TACR1 TAC1
42 positive regulation of neuroinflammatory response GO:0150078 9.7 TNF IL6 IL1B
43 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
44 positive regulation of prostaglandin secretion GO:0032308 9.68 IL1B EDN1
45 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 TNF IL10
46 negative regulation of smooth muscle contraction GO:0045986 9.67 CALCA ADRB2
47 positive regulation of action potential GO:0045760 9.66 TAC1 ADRA1A
48 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
49 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
50 detection of abiotic stimulus GO:0009582 9.64 TACR1 TAC1

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 POMC NPY EDN1 CCL2 CALCA
2 hormone activity GO:0005179 9.26 POMC NPY EDN1 CALCA
3 cytokine activity GO:0005125 9.23 TNF IL6 IL2 IL1B IL10 EDN1
Sources

Sources for Complex Regional Pain Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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