Complex Regional Pain Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

CRPS MCID: CMP010 MIFTS: 59	Complex Regional Pain Syndrome (CRPS) Categories: Neuronal diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Complex Regional Pain Syndrome

MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome ¹¹ ¹⁹ ⁵² ⁵⁸ ⁷⁵ ⁴¹ ¹⁴ ¹⁶

Complex Regional Pain Syndromes ¹¹ ⁵³ ⁴³ ⁷¹

Reflex Sympathetic Dystrophy ¹⁹ ⁷¹

Crps ¹⁹

Characteristics:

Prevelance:

1-5/10000 (Netherlands) ⁵⁸

Age Of Onset:

All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

Disease Ontology ¹¹ DOID:3223

MeSH ⁴³ D020918

SNOMED-CT ⁶⁸ 128200000

MESH via Orphanet ⁴⁴ D020918

ICD10 via Orphanet ³² G90.5 G90.6

UMLS via Orphanet ⁷² C0458219

Orphanet ⁵⁸ ORPHA83452

SNOMED-CT via HPO ⁶⁹ 102542000 102558002 102572006 more

EFO ¹⁶ EFO_1001998

UMLS ⁷¹ C0034931 C0458219

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Summaries for Complex Regional Pain Syndrome

NINDS: ⁵² Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration. Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed. The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe. Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb. In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma. Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary: Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and causalgia, and has symptoms including tremor, back pain and headache. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Signal Transduction and NF-KappaB Family Pathway. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, dorsal root ganglion and spinal cord, and related phenotypes are limb pain and dry skin

MedlinePlus: ⁴¹ Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are: Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally the symptoms go away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

GARD: ¹⁹ Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area, skin sensitivity, sweating, and swelling. The underlying cause of CRPS is often not known.

Orphanet: ⁵⁸ Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.

Wikipedia: ⁷⁵ Complex regional pain syndrome (CRPS) is any of several painful conditions that are characterized by a... more...

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Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 838)

#	Related Disease	Score	Top Affiliating Genes
1	reflex sympathetic dystrophy	32.7	TRPV1 TAC1 SCN9A SCN11A NGF CALCA
2	causalgia	32.4	TRPV1 TACR1 TAC1 SCN9A SCN10A NGF
3	chronic pain	31.5	SCN9A P2RX3 OPRM1 BDNF
4	carpal tunnel syndrome	31.2	TAC1 IL6 IL1B
5	radiculopathy	31.0	TAC1 IL6 CALCA
6	common cold	30.8	TNF IL6 IL1B
7	neuroma	30.7	TRPV1 SCN10A NGF IL6 CALCA
8	spinal cord injury	30.7	TNF IL6 BDNF
9	spondyloarthropathy 1	30.6	TNF IL6 IL1B
10	chickenpox	30.6	TNF IL6 IL1B
11	exanthem	30.6	TNF IL6 IL1B
12	post-traumatic stress disorder	30.6	IL6 IL1B BDNF
13	tenosynovitis	30.5	TNF IL6 IL1B
14	chondromalacia	30.5	TNF IL6 IL1B
15	headache	30.5	TNF CALCA BDNF
16	epicondylitis	30.5	TACR1 TAC1 CALCA
17	spondylitis	30.4	TNF IL6 IL1B
18	bone disease	30.4	TNF MIR223 MIR21 IL6 CALCA
19	septic arthritis	30.4	TNF IL6 IL1B
20	rubella	30.4	TNF IL6 IL1B
21	cellulitis	30.4	TNF IL6 IL1B
22	back pain	30.4	IL6 IL1B BDNF
23	ischemia	30.3	TNF MIR21 KNG1 IL6 BDNF
24	motion sickness	30.3	TACR1 TAC1 OPRM1
25	frozen shoulder	30.3	TNF TAC1 IL6 IL1B CALCA
26	proteasome-associated autoinflammatory syndrome 1	30.3	TNF IL6 IL1B
27	lyme disease	30.3	TNF IL6 IL1B
28	leprosy 3	30.3	TNF IL6 IL1B
29	pneumonia	30.3	TNF MIR223 IL6 IL1B
30	keratopathy	30.3	TAC1 NGF IL6 CALCA
31	crohn's disease	30.3	TNF MIR21 IL6 IL1B
32	neuritis	30.2	TNF IL6 IL1B BDNF
33	chronic fatigue syndrome	30.2	TNF IL6 IL1B BDNF
34	cartilage disease	30.2	TNF IL6 IL1B
35	degenerative disc disease	30.2	TNF MIR223 IL1B
36	mononeuropathy	30.2	TRPV1 TNF TAC1 NGF IL6 CALCA
37	spondyloarthropathy	30.2	TNF IL6 IL1B
38	peptic ulcer disease	30.2	TNF IL6 IL1B
39	peripheral artery disease	30.2	TNF MIR21 IL6
40	long covid	30.2	TNF IL6 IL1B
41	angina pectoris	30.2	TNF KNG1 IL6
42	tendinitis	30.1	TNF TAC1 IL6 IL1B
43	spondylosis	30.1	TNF TAC1 IL6 IL1B
44	stroke, ischemic	30.1	TNF MIR21 IL6 IL1B BDNF
45	nerve compression syndrome	30.1	TRPV1 TAC1 NGF IL6 CALCA
46	cryoglobulinemia	30.1	TNF IL6 IL1B
47	urinary tract infection	30.1	TNF IL6 IL1B
48	migraine with aura	30.1	TAC1 SCN9A OPRM1 IL6 CALCA
49	systemic scleroderma	30.1	TNF MIR21 IL6 IL1B
50	paine syndrome	30.1	TRPV1 TRPA1 TNF TACR1 TAC1 SCN9A

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:

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Symptoms & Phenotypes for Complex Regional Pain Syndrome

Human phenotypes related to Complex Regional Pain Syndrome:

⁵⁸ ³⁰ (show all 13)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	limb pain ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0009763
2	dry skin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000958
3	involuntary movements ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0004305
4	erythema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010783
5	pedal edema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010741
6	slow-growing nails ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0008383
7	allodynia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012533
8	edema of the upper limbs ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010742
9	trophic changes related to pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010834
10	abnormality of hair growth ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0040170
11	dysesthesia ³⁰	Frequent (33%)		HP:0012534
12	sensory impairment ⁵⁸		Frequent (79-30%)
13	hyperalgesia ⁵⁸		Frequent (79-30%)

UMLS symptoms related to Complex Regional Pain Syndrome:

tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; neuralgia

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.17	BDNF CALCA IL1B IL6 NGF OPRM1
2	behavior/neurological	MP:0005386	10.13	BDNF CALCA IL6 KNG1 NGF OPRM1
3	no phenotypic analysis	MP:0003012	9.91	BDNF NGF OPRM1 SCN10A TNF TRPA1
4	respiratory system	MP:0005388	9.81	BDNF CALCA IL6 MIR223 P2RX3 SCN10A
5	integument	MP:0010771	9.5	BDNF CALCA IL1B IL6 NGF OPRM1
6	taste/olfaction	MP:0005394	9.26	BDNF SCN9A TRPA1 TRPV1

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Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Memantine

Approved, Investigational

Phase 4

41100-52-1, 19982-08-2

4054

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 4

1401-55-4

16129878 16129778

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Ascorbic acid

Approved, Nutraceutical

Phase 4

50-81-7

54676860 54670067 5785

Analgesics

Phase 4

Neurotransmitter Agents

Phase 4

Anti-Arrhythmia Agents

Phase 4

Sodium Channel Blockers

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Anesthetics, Local

Phase 4

Anesthetics

Phase 4

Diuretics, Potassium Sparing

Phase 4

Vitamins

Phase 4

Trace Elements

Phase 4

Antioxidants

Phase 4

Micronutrients

Phase 4

Protective Agents

Phase 4

Analgesics, Opioid

Phase 4

Narcotics

Phase 4

Dopamine Agents

Phase 4

Antiparkinson Agents

Phase 4

Triamcinolone hexacetonide

Phase 4

Triamcinolone diacetate

Phase 4

Pharmaceutical Solutions

Phase 4

Triamcinolone Acetonide

Phase 4

6436

Hormone Antagonists

Phase 4

Potassium phosphate

Phase 4

glucocorticoids

Phase 4

Levobupivacaine

Approved, Investigational

Phase 3

27262-47-1

92253

Zoledronic acid

Approved

Phase 3

118072-93-8

68740

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 3

437-38-7

3345

Nitrous oxide

Approved, Vet_approved

Phase 3

10024-97-2

948

Chlorhexidine

Approved, Vet_approved, Withdrawn

Phase 3

55-56-1

2713 9552079

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 3

22737-96-8, 68-26-8

5280382 445354

Imidacloprid

Vet_approved

Phase 3

105827-78-9

86418

Diphosphonates

Phase 3

Anesthetics, Intravenous

Phase 3

Anesthetics, General

Phase 3

Anesthetics, Inhalation

Phase 3

Retinol palmitate

Phase 3

Chlorhexidine gluconate

Phase 3

Dronabinol

Approved, Illicit

Phase 2

1972-08-3

16078

Midazolam

Approved, Illicit

Phase 2

59467-70-8

4192

Cetuximab

Approved

Phase 2

205923-56-4

Ketamine

Approved, Vet_approved

Phase 2

6740-88-1, 1867-66-9

3821

Lenalidomide

Approved

Phase 2

191732-72-6

216326

Ethosuximide

Approved

Phase 2

77-67-8

3291

Interventional clinical trials:

(show top 50) (show all 148)

#	Name	Status	NCT ID	Phase	Drugs
1	Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief	Completed	NCT02265848	Phase 4
2	A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions	Completed	NCT00904202	Phase 4	Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
3	Restore Claims Characterization Study	Completed	NCT00200122	Phase 4
4	Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome	Completed	NCT00296868	Phase 4	ascorbic acid (vitamin C) versus placebo
5	Assessing the Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome - a Feasibility Study	Completed	NCT03291197	Phase 4	Suprascapular and median nerve blocks
6	Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome	Completed	NCT02467556	Phase 4	Morphine, memantine
7	Peripheral Nerve Injections for the Treatment of Upper Extremity Complex Regional Pain Syndrome: A Feasibility Study for a Proposed Randomized Design	Not yet recruiting	NCT04744675	Phase 4	Triamcinolone Acetonide 40mg/mL;Saline Injection
8	Double-Blind Randomized Controlled Trial: Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb	Unknown status	NCT01612364	Phase 3
9	An Analysis of Photoplethysmographic Signal in Diagnostic Lumbar Sympathetic Block for Complex Regional Pain Syndrome	Unknown status	NCT01134289	Phase 3
10	CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zoledronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I)	Unknown status	NCT02504008	Phase 3	AXS-02 (oral zoledronate);Placebo
11	Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy	Unknown status	NCT01392599	Phase 3
12	Acupuncture and Traditional Chinese Medicine Combined With Rehabilitation Therapy for Post-stroke Shoulder-hand Syndrome in Community Hospital: a Multicenter，Randomized，Controlled Trial	Unknown status	NCT02011854	Phase 2, Phase 3
13	Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I	Completed	NCT00817128	Phase 2, Phase 3
14	Open-label Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS)	Completed	NCT02972359	Phase 3	Neridronic acid
15	Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidamide in the Treatment of Complex Regional Pain Syndrome Type1	Completed	NCT00166452	Phase 3	Lenalidamide
16	A Randomized, Double-blind Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome Type I (CRPS-I)	Completed	NCT02402530	Phase 2, Phase 3	Placebo;Neridronic acid 62.5 mg
17	A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome	Completed	NCT01008553	Phase 3	Fentanyl;Placebo
18	Pilot Study to Evaluate the Effectiveness of a Mixture of Ketamine / Lidocaine Administered by Mesotherapy in the Management of Neuropathic Pain in Complex Regional Pain Syndrome Type 1 (CRPS1). A Monocentric Randomized and Controlled Clinical Study	Recruiting	NCT04650074	Phase 2, Phase 3	LIDOCAINE 20 mg;LIDOCAINE 20 mg + KETAMINE 20 mg;LIDOCAINE 20 mg + KETAMINE 40 mg
19	Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery	Recruiting	NCT02390505	Phase 3	Vitamin C;Placebo
20	A Prospective Randomized Controlled Pilot Study Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome	Enrolling by invitation	NCT03879538	Phase 3	Nitrous Oxide;Oxygen
21	A Novel Treatment Approach to Complex Regional Pain Syndrome (CRPS): A Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy	Not yet recruiting	NCT05589259	Phase 3
22	Placebo-controlled Efficacy and Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS)	Terminated	NCT03560986	Phase 3	Neridronic acid 100 mg;Placebo
23	Randomized, Double-blind, Placebo-controlled Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS)	Terminated	NCT03530345	Phase 3	Neridronic acid 100 mg;Placebo
24	Prospective, Double-blind, Randomised, Placebo-controlled, Cross-over Study to Investigate the Effect of Intravenous Immunoglobulins on Complex Regional Pain Syndrome (CRPS, M. Sudeck)	Withdrawn	NCT00949065	Phase 3
25	Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb	Unknown status	NCT00377468	Phase 2	Delta9-Tetrahydrocannabinol
26	Phase 2 Study - The Use of a Single 5 mg Dose of Zoledronic Acid in Complex Regional Pain Syndrome Patient.	Unknown status	NCT01788176	Phase 2	Zoledronic acid;Placebo
27	A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 as an Adjunctive Therapy in Adult Subjects With Chronic Complex Regional Pain Syndrome	Completed	NCT03990649	Phase 2	Soticlestat;Placebo
28	Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS	Completed	NCT00579085	Phase 2	Ketamine
29	A Multicenter, Open-Label Study to Evaluate the Preliminary Safety and Efficacy of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS)	Completed	NCT00067743	Phase 2	Lenalidomide
30	A Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset Complex Regional Pain Syndrome After Total Knee Arthroplasty	Completed	NCT00558753	Phase 2	pregabalin;Placebo
31	A Randomized, Cross-over, Placebo-controlled, Double-blind, Single-center, Phase II Study of Cetuximab in Patients With Treatment-refractory, Non-malignant Severe Chronic Neuropathic Pain	Completed	NCT02490436	Phase 2	Cetuximab;Placebo
32	CCRC: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain	Completed	NCT01037088	Phase 1, Phase 2	Mild dose cannabis;Low dose cannabis;Cannabis
33	Neurotropin for Acute Dental Pain and for Chronic Neuropathic Pain	Terminated	NCT00006289	Phase 2	Placebo;Neurotropin
34	Randomized Controlled Trial of Subanesthetic Intravenous Ketamine Infusion in Conjunction With Continuous Epidural Infusion for Treatment of Refractory Complex Regional Pain Syndrome	Terminated	NCT02094352	Phase 2	Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
35	A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1	Terminated	NCT00109772	Phase 2	lenalidomide;Placebo
36	A Single Centre. Parallel-Group, Double-Blinded, Randomized, Placebo-Controlled Pilot Clinical Trial on Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)	Terminated	NCT00689585	Phase 2	Placebo;Ethosuximide
37	Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia	Withdrawn	NCT02987855	Phase 1, Phase 2
38	Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain.	Terminated	NCT02321566	Phase 1
39	Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block: A Prospective Randomized Open-label Trial	Unknown status	NCT02737527		10 ml of 0.25% levobupivacaine injection for LSB
40	Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes in Individuals With Difficulties in Weight-bearing	Unknown status	NCT02742376
41	Effects of Repetitive Electric Sensory Stimulation on Sensorimotor Performance and Pain Intensity in Complex Regional Pain Syndrome Type I	Unknown status	NCT01915329
42	"Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"	Unknown status	NCT03616262	Early Phase 1	Botox + Lidocaine;Lidocaine alone
43	Treatment of Complex Regional Pain Syndrome, a Qualitative Interview Study and a Case Series With Long-term Follow-up	Unknown status	NCT04597866
44	Identifying Markers of Trajectory in Pediatric Complex Regional Pain Syndrome	Unknown status	NCT03838107
45	The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture, Prospective Double Blind Study	Unknown status	NCT01338129		placebo
46	Effects of Proprioceptive Stimulation Under Visual Feedback in Patient With CRPS: An Exploratory Study	Unknown status	NCT02395211
47	EFFECTIVENESS OF GRADED MOTOR IMAGERY TO PREVENT CRPS IN PATIENTS WITH DISTAL RADIUS FRACTURE AFTER SURGERY: A RANDOMIZED CONTROLLED TRIAL	Unknown status	NCT03937492
48	Comparison of Two Measures of Tactile Acuity in CRPS Type I Patients , Patients With a Neuropathy of the Median Nerve and Healthy Controls.	Unknown status	NCT01888783
49	Comparison of Methods of Lumbar Sympathetic Ganglion Block: Distance vs Angle	Unknown status	NCT01648543
50	Distances From Cricoid Cartilage to the Targets of Stellate Ganglion Block	Unknown status	NCT01601925

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Ethanol

Cochrane evidence based reviews: complex regional pain syndromes

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Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

Organs/tissues related to Complex Regional Pain Syndrome:

MalaCards : Skin, Dorsal Root Ganglion, Spinal Cord, Cortex, Bone, Brain, Bone Marrow

Sources

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 5647)

#	Title	Authors	PMID	Year
1	Parameters of Spinal Cord Stimulation in Complex Regional Pain Syndrome: Systematic Review and Meta-analysis of Randomized Controlled Trials. ⁶² ⁴¹	Ho E...Agarwal S	36375180	2022
2	Post-fracture serum cytokine levels are not associated with a later diagnosis of complex regional pain syndrome: a case-control study nested in a prospective cohort study. ⁶² ⁴¹	Parkitny L...Moseley GL	36224537	2022
3	Combining Stellate ganglion block and intravenous regional anesthesia to treat complex regional pain syndrome: A 19-years' experience in a tertiary center. ⁶² ⁴¹	Aloweidi AS...Al-Oweidi AA	36261198	2022
4	Pharmacotherapy options for complex regional pain syndrome. ⁵³ ⁶²	Eisenberg E...Brill S	17492902	2007
5	Efficacy of salmon calcitonin in complex regional pain syndrome (type 1) in addition to physical therapy. ⁵³ ⁶²	Sahin F...Kuran B	15980934	2006
6	[Experiences with calcitonin treatment of patients with type I complex regional pain syndrome (CRPS I--Sudeck disease)]. ⁵³ ⁶²	Schurmann M...Gradl G	11605299	2001
7	Assessing spatial connectivity effects on daily streamflow forecasting using Bayesian-based graph neural network. ⁶²	Liu G...Zhou J	36162576	2023
8	Bioreduction mechanisms of high-concentration hexavalent chromium using sulfur salts by photosynthetic bacteria. ⁶²	Su YQ...Chen YE	36243096	2023
9	Dorsal bridging plates for the treatment of high and low energy distal radius fractures. ⁶²	Roberts T...Cowey A	36340961	2022
10	Cholesterol-binding sequence is a key regulatory motif of cellular folding and conformational activation for C-reactive protein. ⁶²	Lv JM...Li HY	36334345	2022
11	[Electrotherapeutical stellate ganglion block on a patient with complex regional pain syndrome of the upper limb]. ⁶²	Ranker A...Behr-Eggers E	36459205	2022
12	Successful Multimodal Treatment for Complex Regional Pain Syndrome in an Adolescent with Acute Lymphoblastic Leukemia: A Case Report. ⁶²	Meeks H...Frett MJ	34936831	2022
13	Autoantibodies from patients with complex regional pain syndrome induce pro-inflammatory effects and functional disturbances on endothelial cells in vitro. ⁶²	Dharmalingam B...Tschernatsch M	35384930	2022
14	Nociception level index variations in patients with complex regional pain syndrome: a pilot study. ⁶²	Santella TM...Brulotte V	35260985	2022
15	The Language of Pain: Is There a Relationship Between Metaphor Use and Adjustment to Chronic Pain? ⁶²	Munday I...Newton-John T	33729513	2022
16	Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review. ⁶²	Lee JH...Argoff CE	36288104	2022
17	Techniques for Safe Removal of Spinal Cord Stimulation Paddle Leads. ⁶²	Topp G...Pilitsis JG	36227247	2022
18	[Less invasive turn-down flap tendinoplasty in chronic Achilles tendon rupture]. ⁶²	Amlang MH...Rammelt S	36036248	2022
19	Chronic Pain Considerations in Patients with Cardiovascular Disease. ⁶²	Layne-Stuart CM...Carpenter AL	36328629	2022
20	[Surgical treatment of calcifying insertional Achilles tendinopathy via a lateral approach]. ⁶²	Amlang MH...Rammelt S	36342529	2022
21	The epidemiology of dystonia: the Hannover epidemiology study. ⁶²	Dressler D...Adib Saberi F	35948800	2022
22	Complications and Functional Outcomes following Trigger Finger Release: A Cohort Study of 1879 Patients. ⁶²	Koopman JE...Hand-Wrist Study Group	35994343	2022
23	Peripheral Nerve Stimulation in Painful Conditions of the Upper Extremity-An Overview. ⁶²	Yaccarino V...Sehgal N	36359295	2022
24	Use of Hand Therapy After Distal Radius Fracture: A National Perspective. ⁶²	Trinh P...Curtin C	34666936	2022
25	Reciprocal interaction of pain and brain: Plasticity-induced pain, pain-induced plasticity, and therapeutic targets. ⁶²	Kourosh Arami M...Komaki A	36330624	2022
26	Dorsal Root Ganglion Stimulation for the Treatment of Joint Pain with Predominantly Nociceptive Characteristics: A Case Series. ⁶²	Chapman KB...Yousef T	36334041	2022
27	A modified three-incision approach to treating three-column Lisfranc injuries. ⁶²	Zhao TH...Ren W	35985903	2022
28	A novel distractor-assisted reduction combined with the sinus tarsi approach for joint depression-type calcaneal fractures. ⁶²	Zhang H...Jie K	36370163	2022
29	Molecular and clinical markers of pain relief in complex regional pain syndrome: An observational study. ⁶²	Reinhold AK...Rittner HL	36440973	2022
30	Efficacy and Safety of Cervical and High-Thoracic Dorsal Root Ganglion Stimulation Therapy for Complex Regional Pain Syndrome of the Upper Extremities. ⁶²	Graca MJ...McCarthy RJ	36402657	2022
31	Clinical practice guidelines for the management of patients with complex regional pain syndrome: a systematic appraisal using the AGREE II instrument. ⁶²	Javed S...Huh BK	36193759	2022
32	Reporting of Interventions for Treating Complex Regional Pain Syndrome in Randomized Controlled Trials Using the Template for Intervention Description and Replication Checklist. ⁶²	Yazdanpanah N...Agarwal S	36342209	2022
33	Amputation for Complex Regional Pain Syndrome: Meta-Analysis and Validation of a Histopathology Scoring System. ⁶²	Howard EL...Soulakvelidze I	36355456	2022
34	Cervical dorsal root ganglion stimulation for complex regional pain syndrome: Technical description and results of seven cases. ⁶²	Rosado Caracena R...Garcia de Lucas F	36380700	2022
35	Olfaction in complex regional pain syndrome. ⁶²	Finch PM...Drummond PD	36409035	2022
36	Glucocorticoid treatment in patients with complex regional pain syndrome: A systematic review. ⁶²	van den Berg C...Tiemensma J	35983980	2022
37	Assessment of body perception disturbances in complex regional pain syndrome: A systematic review using the COSMIN guideline. ⁶²	Acapo S...Nizard J	36065635	2022
38	Long-term Outcomes in Use of Opioids, Nonpharmacologic Pain Interventions, and Total Costs of Spinal Cord Stimulators Compared With Conventional Medical Therapy for Chronic Pain. ⁶²	Dhruva SS...Cohen K	36441532	2022
39	Postoperative Imaging of the Wrist and Hand. ⁶²	Llopis E...Pinal FD	36243510	2022
40	Pharmacologic Treatments in Upper Extremity Complex Regional Pain Syndrome: A Review and Analysis of Quality of Evidence. ⁶²	Tihista M...Dunn J	36424817	2022
41	Multiomics Profiling of Toxins in the Venom of the Amazonian Spider Acanthoscurria juruenicola. ⁶²	Nishiduka ES...Tashima AK	36260604	2022
42	Insights into the role of complement regulatory proteins in HPV mediated cervical carcinogenesis. ⁶²	Khan A...Rashid S	34087416	2022
43	LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo-Inspired pH/Tactility Artificial Receptors. ⁶²	Yuan R...Ge L	36377355	2022
44	Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume. ⁶²	He M...Zhang L	36270560	2022
45	BONE-360: a new app to diagnose CRPS type 1. ⁶²	Saviola G...GEODEIT (Gruppo Edema Osseo Diagnosi ed Interventi Terapeutici)	36475536	2022
46	Photoluminescence Path Bifurcations by Spin Flip in Two-Dimensional CrPS4. ⁶²	Kim S...Ryu S	36129115	2022
47	The Role of C-reactive Protein Estimation in Determining the Duration of Antibiotic Therapy in Neonatal Sepsis. ⁶²	Chaudhuri PK...Kumar S	36246087	2022
48	Recent Trends in Medicare Utilization and Reimbursement for Spinal Cord Stimulators: 2000-2019. ⁶²	Romaniuk M...Gottfried O	35872133	2022
49	A five-year retrospective cohort study of carpal tunnel surgery complications in an Australian population. ⁶²	Zhou MA...Dean NR	36203391	2022
50	Complex regional pain syndrome of the foot and ankle following knee arthroscopy. ⁶²	Evans T...Gobindpuri A	36322439	2022

Sources

Genes for Complex Regional Pain Syndrome

Genes related to Complex Regional Pain Syndrome (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	23.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11605299 15980934 17492902
2	MIR548D1	MicroRNA 548d-1	RNA Gene	10.77	DISEASES inferred ¹⁴ ¹⁴
3	MIR3678	MicroRNA 3678	RNA Gene	7.94	DISEASES inferred ¹⁴ ¹⁴
4	TAC1	Tachykinin Precursor 1	Protein Coding	7.83	DISEASES inferred ¹⁴
5	MIR21	MicroRNA 21	RNA Gene	7.17	DISEASES inferred ¹⁴ ¹⁴
6	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	6.99	DISEASES inferred ¹⁴
7	NGF	Nerve Growth Factor	Protein Coding	6.83	DISEASES inferred ¹⁴
8	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	6.74	DISEASES inferred ¹⁴
9	TACR1	Tachykinin Receptor 1	Protein Coding	6.58	DISEASES inferred ¹⁴
10	MIR223	MicroRNA 223	RNA Gene	6.57	DISEASES inferred ¹⁴ ¹⁴
11	TRPA1	Transient Receptor Potential Cation Channel Subfamily A Member 1	Protein Coding	6.56	DISEASES inferred ¹⁴
12	KNG1	Kininogen 1	Protein Coding	6.41	DISEASES inferred ¹⁴
13	IL1B	Interleukin 1 Beta	Protein Coding	6.38	DISEASES inferred ¹⁴
14	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	6.33	DISEASES inferred ¹⁴
15	IL6	Interleukin 6	Protein Coding	6.32	DISEASES inferred ¹⁴
16	OPRM1	Opioid Receptor Mu 1	Protein Coding	6.21	DISEASES inferred ¹⁴
17	P2RX3	Purinergic Receptor P2X 3	Protein Coding	6.14	DISEASES inferred ¹⁴
18	TNF	Tumor Necrosis Factor	Protein Coding	6.08	DISEASES inferred ¹⁴
19	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	6	DISEASES inferred ¹⁴
20	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	5.97	DISEASES inferred ¹⁴
21	RAMP1	Receptor Activity Modifying Protein 1	Protein Coding	5.82	DISEASES inferred ¹⁴
22	TRPM8	Transient Receptor Potential Cation Channel Subfamily M Member 8	Protein Coding	5.81	DISEASES inferred ¹⁴
23	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5.76	DISEASES inferred ¹⁴
24	MIR939	MicroRNA 939	RNA Gene	5.71	DISEASES inferred ¹⁴
25	IL10	Interleukin 10	Protein Coding	5.71	DISEASES inferred ¹⁴

Sources

Variations for Complex Regional Pain Syndrome

Sources

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Sources

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.71	TNF TACR1 TAC1 OPRM1 NGF KNG1
2	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.62	TNF NGF IL6 IL1B BDNF
3	Neuropathic Pain-Signaling in Dorsal Horn Neurons ⁶⁴ Show member pathways Aldosterone Signaling in Epithelial Cells ⁶⁴ Cholera Infection ⁶⁴	12.5	TACR1 TAC1 SCN9A SCN11A SCN10A BDNF
4	Neuroscience ³	12.38	CALCA NGF OPRM1 SCN10A SCN11A SCN9A
5	MAPK signaling pathway ⁷⁴	12.33	TNF NGF IL1B BDNF
6	Neuroinflammation and glutamatergic signaling ⁷⁴	11.87	TNF NGF IL6 IL1B BDNF
7	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.79	TNF OPRM1 IL6 IL1B
8	Burn wound healing ⁷⁴	11.68	TNF IL6 IL1B
9	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.67	TNF IL6 IL1B
10	Spinal cord injury ⁷⁴	11.61	TNF TACR1 IL6 IL1B BDNF
11	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.6	TNF IL6 IL1B
12	miRNAs involvement in the immune response in sepsis ⁷⁴	11.58	TNF MIR21 IL6
13	IL 10 signaling pathway ⁶⁷	11.57	TNF IL6 IL1B
14	SHP2 signaling ⁶¹	11.5	NGF IL6 BDNF
15	Lung fibrosis ⁷⁴	11.5	TNF IL6 IL1B CALCA
16	Interleukin-10 signaling ⁶⁶	11.42	TNF IL6 IL1B
17	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.37	TNF TACR1 TAC1 NGF IL6 IL1B
18	IL-10 Pathway ⁶⁴	11.28	TNF IL6 IL1B
19	Phase 0 - rapid depolarisation ⁶⁶	11.26	SCN9A SCN11A SCN10A
20	Development and heterogeneity of the ILC family ⁷⁴	11.22	IL1B IL6 TNF
21	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.21	TNF IL6 IL1B CALCA
22	Interaction between L1 and Ankyrins ⁶⁶	11.19	SCN9A SCN11A SCN10A
23	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.16	TNF IL6 IL1B
24	Cytokines and inflammatory response ⁷⁴	11.13	TNF IL6 IL1B
25	Prostaglandin signaling ⁷⁴	11.1	TNF IL6 IL1B
26	G-protein signaling_Rap2B regulation pathway ²²	10.95	TNF NGF IL6 IL1B BDNF
27	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.73	IL6 IL1B
28	NK1R-mediated Non-Apoptotic PCD ⁶⁴	10.46	TAC1 TACR1
29	Tachykinin receptors bind tachykinins ⁶⁶	10.28	TACR1 TAC1
30	Chronic hyperglycemia impairment of neuron function ⁷⁴	10.04	TRPV1 TRPA1
31	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	9.83	TNF KNG1 IL6

Sources

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.34	TRPV1 TRPA1 TNF TACR1 SCN9A P2RX3
2	plasma membrane	GO:0005887	10.34	TRPV1 TRPA1 TNF TACR1 SCN9A P2RX3
3	neuronal cell body	GO:0043025	9.9	CALCA P2RX3 SCN11A TAC1 TNF TRPV1
4	axon	GO:0030424	9.53	TAC1 SCN9A SCN11A SCN10A P2RX3 OPRM1
5	obsolete integral component of presynaptic membrane	GO:0099056	9.43	SCN10A P2RX3 OPRM1
6	voltage-gated sodium channel complex	GO:0001518	9.43	SCN9A SCN11A SCN10A

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 45)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell population proliferation	GO:0008285	10.36	TNF OPRM1 NGF MIR21 IL6 IL1B
2	calcium ion transmembrane transport	GO:0070588	10.22	TRPV1 TRPA1 SCN11A OPRM1
3	positive regulation of peptidyl-serine phosphorylation	GO:0033138	10.21	BDNF IL6 NGF TNF
4	monoatomic ion transport	GO:0006811	10.19	TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3
5	inflammatory response	GO:0006954	10.19	CALCA IL1B IL6 KNG1 SCN9A TAC1
6	regulation of insulin secretion	GO:0050796	10.17	TNF IL6 IL1B
7	positive regulation of cytosolic calcium ion concentration	GO:0007204	10.17	CALCA KNG1 OPRM1 TAC1 TACR1 TRPV1
8	response to cold	GO:0009409	10.16	TRPA1 SCN9A P2RX3
9	cellular response to lipopolysaccharide	GO:0071222	10.14	TNF MIR223 MIR21 IL6 IL1B
10	cellular response to nerve growth factor stimulus	GO:1990090	10.13	TRPV1 TAC1 CALCA
11	positive regulation of interleukin-8 production	GO:0032757	10.11	TNF IL6 IL1B CALCA
12	positive regulation of chemokine production	GO:0032722	10.09	TNF IL6 IL1B
13	negative regulation of neurogenesis	GO:0050768	10.09	TNF IL6 IL1B
14	embryo implantation	GO:0007566	10.08	MIR21 IL1B CALCA
15	neuronal action potential	GO:0019228	10.08	SCN9A SCN11A SCN10A P2RX3
16	vasodilation	GO:0042311	10.07	TNF KNG1 CALCA
17	positive regulation of glial cell proliferation	GO:0060252	10.06	IL1B IL6 TNF
18	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.05	TRPV1 TNF OPRM1 IL1B
19	membrane depolarization during action potential	GO:0086010	10.03	SCN9A SCN11A SCN10A
20	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.02	TNF MIR21 IL6
21	positive regulation of neuroinflammatory response	GO:0150078	10	IL1B IL6 TNF
22	positive regulation of action potential	GO:0045760	9.99	TNF TACR1
23	acute inflammatory response	GO:0002526	9.99	TNF TACR1 SCN11A
24	positive regulation of fever generation	GO:0031622	9.98	IL1B TNF
25	monoatomic ion transmembrane transport	GO:0034220	9.97	TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3
26	detection of abiotic stimulus	GO:0009582	9.96	TAC1 TACR1
27	sequestering of triglyceride	GO:0030730	9.96	IL1B TNF
28	thermoception	GO:0050955	9.96	TRPA1 TRPV1
29	detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	9.95	TRPA1 TNF SCN11A
30	fever generation	GO:0001660	9.94	IL1B TRPV1
31	detection of chemical stimulus involved in sensory perception of pain	GO:0050968	9.94	TRPA1 TRPV1
32	smooth muscle contraction involved in micturition	GO:0060083	9.93	TACR1 TRPV1
33	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.93	IL1B TNF
34	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.93	TNF MIR21 IL6
35	vascular endothelial growth factor production	GO:0010573	9.93	TNF IL6 IL1B
36	monoatomic cation transmembrane transport	GO:0098655	9.88	SCN9A SCN11A SCN10A P2RX3
37	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.87	MIR21 IL6
38	urinary bladder smooth muscle contraction	GO:0014832	9.86	TRPV1 P2RX3
39	detection of temperature stimulus involved in sensory perception of pain	GO:0050965	9.85	TRPV1 SCN9A SCN11A CALCA
40	response to heat	GO:0009408	9.85	TRPV1 TACR1 SCN9A SCN11A P2RX3 CALCA
41	behavioral response to formalin induced pain	GO:0061368	9.8	SCN9A SCN11A P2RX3
42	behavioral response to pain	GO:0048266	9.8	TRPV1 TACR1 SCN9A P2RX3
43	calcitonin gene-related peptide receptor signaling pathway	GO:1990408	9.62	CALCA SCN11A
44	response to pain	GO:0048265	9.56	TRPV1 TRPA1 TACR1 TAC1 CALCA
45	sensory perception of pain	GO:0019233	9.44	TRPV1 TRPA1 TACR1 TAC1 SCN9A SCN10A

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.87	TNF NGF KNG1 IL6 CALCA BDNF
2	voltage-gated sodium channel activity	GO:0005248	9.73	SCN9A SCN11A SCN10A
3	nerve growth factor receptor binding	GO:0005163	9.67	NGF BDNF
4	sodium channel activity	GO:0005272	9.33	SCN9A SCN11A SCN10A
5	monoatomic cation channel activity	GO:0005261	9.26	TRPV1 SCN9A SCN11A SCN10A
6	monoatomic ion channel activity	GO:0005216	9.17	TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3