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CRPS
MCID: CMP010
MIFTS: 62

Complex Regional Pain Syndrome (CRPS)

Categories: Neuronal diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Complex Regional Pain Syndrome

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MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 76 53 54 43 15
Complex Regional Pain Syndromes 12 55 44 73
Reflex Sympathetic Dystrophy 53 73
Crps 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Complex Regional Pain Syndrome

About this section
NINDS : 54 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and causalgia, and has symptoms including seizures, tremor and back pain. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Lidocaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related phenotypes are dry skin and erythema

NIH Rare Diseases : 53 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is often not known. Two classifications of CRPS have been recognized based on causalgia. Type I (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and Type II, in which peripheral nerve injury is present. Treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy; and/or a sympathetic nerve block.

MedlinePlus : 43 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally it goes away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Complex Regional Pain Syndrome (CRPS), also known as Reflex Sympathetic Dystrophy (RSD), is a disorder... more...

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Related Diseases for Complex Regional Pain Syndrome

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Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 567)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 33.8 CALCA NPY
2 causalgia 33.4 CALCA NPY TAC1
3 autonomic nervous system disease 31.7 CALCA NPY TAC1
4 peripheral nervous system disease 31.5 IL6 SCN9A TAC1 TNF
5 burns 30.6 IL1B TNF
6 vulvar vestibulitis syndrome 30.4 IL1B TNF
7 periodontal disease 30.3 IL1B IL6 TNF
8 spondylitis 30.3 HLA-B IL6 TNF
9 appendicitis 30.1 IL10 IL1B IL6 TNF
10 heart disease 30.1 EDN1 IL10 IL1B IL6 TNF
11 spondyloarthropathy 30.0 HLA-B IL10 IL6 TNF
12 carpal tunnel syndrome 30.0 IL1B IL6 TAC1
13 osteoarthritis 30.0 IL1B IL6 TNF
14 irritable bowel syndrome 30.0 IL10 TAC1 TNF
15 ulcerative colitis 29.9 IL10 IL1B IL6 TNF
16 colitis 29.9 IL10 IL1B IL6 TNF
17 cholangitis 29.9 HLA-B IL6 TNF
18 migraine with or without aura 1 29.9 CALCA TAC1 TNF
19 pre-eclampsia 29.9 EDN1 IL10 IL6 TNF
20 aortic aneurysm, familial abdominal, 1 29.9 CCL2 IL1B IL6
21 fatty liver disease 29.9 IL1B IL6 TNF
22 systemic lupus erythematosus 29.8 CCL2 IL10 IL1B IL6 TNF
23 arthritis 29.8 CCL2 IL10 IL1B IL6 TNF
24 haemophilus influenzae 29.8 IL1B TNF
25 arteries, anomalies of 29.8 CCL2 EDN1 IL1B IL6 TNF
26 cystitis 29.7 CCL2 IL6 TAC1 TNF
27 vascular disease 29.7 CCL2 EDN1 IL6 TNF
28 ischemic heart disease 29.7 CCL2 IL6 TNF
29 takayasu arteritis 29.7 HLA-B IL6 TNF
30 lyme disease 29.7 IL1B IL6 TNF
31 endocarditis 29.7 IL10 IL6 TNF
32 rheumatoid arthritis 29.7 CCL2 HLA-B IL10 IL1B IL6 TNF
33 psoriatic arthritis 29.7 HLA-B IL1B IL6 TNF
34 synovitis 29.7 IL1B IL6 TNF
35 juvenile rheumatoid arthritis 29.6 IL1B IL6 TNF
36 pulmonary disease, chronic obstructive 29.6 CCL2 IL6 TNF
37 kawasaki disease 29.6 CCL2 IL10 IL6 TNF
38 pneumonia 29.6 CCL2 IL10 IL1B IL6 TNF
39 anterior uveitis 29.6 HLA-B IL6 TNF
40 sleep apnea 29.6 EDN1 IL1B IL6 TNF
41 bacterial sepsis 29.6 CALCA IL10 TNF
42 vasculitis 29.6 CCL2 HLA-B TNF
43 apnea, obstructive sleep 29.5 EDN1 IL6 TNF
44 typhoid fever 29.5 IL1B IL6 TNF
45 peptic ulcer disease 29.5 IL10 IL1B TNF
46 psoriasis 29.5 CCL2 IL10 IL1B IL6 TNF
47 temporal arteritis 29.5 CCL2 IL6 TNF
48 hematopoietic stem cell transplantation 29.5 HLA-B IL10 IL6 TNF
49 diabetes mellitus 29.5 EDN1 HLA-B IL1B IL6 TNF
50 meningitis 29.5 CCL2 IL10 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to Complex Regional Pain Syndrome
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Symptoms & Phenotypes for Complex Regional Pain Syndrome

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Human phenotypes related to Complex Regional Pain Syndrome:

32 (show all 11)
# Description HPO Frequency HPO Source Accession
1 dry skin 32 frequent (33%) HP:0000958
2 erythema 32 frequent (33%) HP:0010783
3 involuntary movements 32 frequent (33%) HP:0004305
4 edema of the lower limbs 32 frequent (33%) HP:0010741
5 slow-growing nails 32 frequent (33%) HP:0008383
6 allodynia 32 frequent (33%) HP:0012533
7 limb pain 32 hallmark (90%) HP:0009763
8 edema of the upper limbs 32 frequent (33%) HP:0010742
9 trophic changes related to pain 32 frequent (33%) HP:0010834
10 hyperalgesia 32 frequent (33%) HP:0031005
11 abnormality of hair growth 32 frequent (33%) HP:0040170

UMLS symptoms related to Complex Regional Pain Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 IL10 IL1B IL6 MME SCN9A TAC1
Sources

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
4
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
5
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
6
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
7
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 5785 54670067
8
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
9 Micronutrients Phase 4,Phase 3,Not Applicable
10 Antioxidants Phase 4,Phase 3,Not Applicable
11 Protective Agents Phase 4,Phase 3,Not Applicable
12 Vitamins Phase 4,Phase 3,Not Applicable
13 Trace Elements Phase 4,Phase 3,Not Applicable
14 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
16 Anesthetics, Local Phase 4,Phase 3,Not Applicable,Early Phase 1
17 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
22 triamcinolone acetonide Phase 4,Phase 3,Not Applicable
23 Triamcinolone diacetate Phase 4,Phase 3,Not Applicable
24 Triamcinolone hexacetonide Phase 4,Phase 3,Not Applicable
25 Diuretics, Potassium Sparing Phase 4,Not Applicable,Early Phase 1
26 GABA Agents Phase 4,Not Applicable
27 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Not Applicable
28 Antiparkinson Agents Phase 4,Not Applicable
29 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
30 calcium channel blockers Phase 4,Phase 2,Not Applicable
31 Anticonvulsants Phase 4,Phase 2,Not Applicable
32 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
33 Anti-Anxiety Agents Phase 4,Phase 2,Not Applicable
34 Antimanic Agents Phase 4,Not Applicable
35 Sodium Channel Blockers Phase 4,Not Applicable,Early Phase 1
36 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
37 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
38 Vasodilator Agents Phase 4,Phase 2
39 calcitonin Phase 4
40
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 175805 71273
41
Levobupivacaine Approved, Investigational Phase 3,Not Applicable 27262-47-1 92253
42
Zoledronic acid Approved Phase 3,Phase 2 118072-93-8 68740
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3,Not Applicable 437-38-7 3345
44
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
45
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
46
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
47
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
48 gamma-Globulins Phase 3
49 Immunoglobulins, Intravenous Phase 3
50 Rho(D) Immune Globulin Phase 3

Interventional clinical trials:

(show top 50) (show all 136)
# Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
6 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
7 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
8 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
9 (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes Not yet recruiting NCT03796195 Phase 4 .5% Bupivacaine
10 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
11 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
12 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
13 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
14 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
15 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
16 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
17 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
18 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
19 Safety of Intravenous Neridronic Acid in CRPS Completed NCT02972359 Phase 3 Neridronic acid
20 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
21 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
22 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
23 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
24 Efficacy and Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT03530345 Phase 3 Neridronic acid;Placebo
25 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
26 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
27 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
28 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
29 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
30 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
31 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
32 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
33 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
34 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
35 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
36 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
37 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
38 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
39 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
40 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
41 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
42 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
43 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
44 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
45 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329 Not Applicable
46 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 Not Applicable placebo
47 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715 Not Applicable
48 Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes Unknown status NCT02742376 Not Applicable
49 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783 Not Applicable
50 Structural and Functional Nerve Changes Following Immobilisation After Distal Radius Fracture - a Pilot Study (NRP) Unknown status NCT02396277

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: complex regional pain syndromes

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Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

41
Skin, Spinal Cord, Bone, Testes, Brain, Cortex, Dorsal Root Ganglion
Sources

Publications for Complex Regional Pain Syndrome

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Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 1181)
# Title Authors Year
1
Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome. ( 29980635 )
2018
2
Signs and Symptoms in 1043 Patients with Complex Regional Pain Syndrome (CRPS). ( 29409933 )
2018
3
Topical Ketamine in the Treatment of Complex Regional Pain Syndrome. ( 29877864 )
2018
4
Fear of movement modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): A single-case study. ( 29317053 )
2018
5
Correlates and importance of neglect-like symptoms in Complex Regional Pain Syndrome. ( 29419655 )
2018
6
Mycophenolate for persistent complex regional pain syndrome, a parallel, open, randomised, proof of concept trial. ( 29794285 )
2018
7
The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis. ( 29404715 )
2018
8
Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology. ( 29794269 )
2018
9
Complex Regional Pain Syndrome Type 1: Diagnosis and Management. ( 29409405 )
2018
10
Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia. ( 29419627 )
2018
11
Long-term Outcomes Using Intrathecal Drug Delivery Systems in Complex Regional Pain Syndrome. ( 29889241 )
2018
12
The Legal Doctrine on the Liability of Physicians in Medical Malpractice Lawsuits Involving Complex Regional Pain Syndrome. ( 29441736 )
2018
13
Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study. ( 29336203 )
2018
14
Spinal cord stimulation in the treatment of complex regional pain syndrome type 1: Is trial truly required? ( 29913360 )
2018
15
Complex Regional Pain Syndrome, Current Concepts and Treatment Options. ( 29404787 )
2018
16
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
2018
17
Complex regional pain syndrome. ( 29858146 )
2018
18
Do we have to rethink Complex Regional Pain Syndrome? ( 29935746 )
2018
19
Utilization of manual therapy to the lumbar spine in conjunction with traditional conservative care for individuals with bilateral lower extremity complex regional pain syndrome: A case series. ( 29873592 )
2018
20
Complex regional pain syndrome of the face in a child. ( 29797456 )
2018
21
Hemi-sensory disturbances in patients with complex regional pain syndrome. ( 29787471 )
2018
22
Utility of Radionuclide Bone Scintigraphy in Complex Regional Pain Syndrome. ( 29388057 )
2018
23
Pain Exposure Physical Therapy versus conventional treatment in complex regional pain syndrome type 1-a cost-effectiveness analysis alongside a randomized controlled trial. ( 29430970 )
2018
24
Vascular Changes of Complex Regional Pain Syndrome Unmask Buerger's Disease (Thromboangiitis Obliterans): A Letter to the Editor. ( 29800280 )
2018
25
Kinesiophobia after complex regional pain syndrome type one in a case of stroke hemiplegia and effect of cognitive behavior therapy. ( 29736085 )
2018
26
Dermal Nerve Fibre and Mast Cell Density, and Proximity of Mast Cells to Nerve Fibres in the Skin of Patients with Complex Regional Pain Syndrome. ( 29905655 )
2018
27
Complex Regional Pain Syndrome after Total Knee Arthroplasty is Rare and Misdiagnosis Potentially Hazardous-Prospective Study of the New Diagnostic Criteria in 100 Patients with No Cases Identified. ( 29294499 )
2018
28
Epidemiology of complex regional pain syndrome in Korea: An electronic population health data study. ( 29864152 )
2018
29
Complex regional pain syndrome type II after cervical transforaminal epidural injection: A case report. ( 29768371 )
2018
30
Extrapyramidal signs occurring after sympathetic block for complex regional pain syndrome responding to diphenhydramine: Two case reports. ( 29953015 )
2018
31
Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy: A Pilot Study. ( 30235917 )
2018
32
Sensory disturbances induced by sensorimotor conflicts are higher in complex regional pain syndrome and fibromyalgia compared to arthritis and healthy people, and positively relate to pain intensity. ( 30288850 )
2018
33
Recurrent Subanesthetic Ketamine Infusions for Complex Regional Pain Syndrome Leading to Biliary Dilation, Jaundice, and Cholangitis: A Case Report. ( 29135531 )
2018
34
Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome. ( 30392459 )
2018
35
Successful treatment of complex regional pain syndrome with topical ambroxol: a case series. ( 30394190 )
2018
36
Decision making process for amputation in case of therapy resistant complex regional pain syndrome type-I in a Dutch specialist centre. ( 30396470 )
2018
37
Prognostic Value of Pain Sensitization During Early Recovery After Distal Radius Fracture in Complex Regional Pain Syndrome. ( 30412230 )
2018
38
Psychiatric Disorders in Complex Regional Pain Syndrome (CRPS): The Role of the Consultation-Liaison Psychiatrist. ( 30416634 )
2018
39
Investigate the Effect of Psychological Factors in Development of Complex Regional Pain Syndrome Type I in Patients with Fracture of the Distal Radius: A Prospective Study. ( 30428789 )
2018
40
Improved Training Paradigms and Motor-decode Algorithms: Results from Intact Individuals and a Recent Transradial Amputee with Prior Complex Regional Pain Syndrome. ( 30441190 )
2018
41
The clinical application of pain neuroscience, graded motor imagery, and graded activity with complex regional pain syndrome-A case report. ( 30499359 )
2018
42
Neurometabolite changes in patients with complex regional pain syndrome using magnetic resonance spectroscopy: a pilot study. ( 30507760 )
2018
43
Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report. ( 30519087 )
2018
44
The Effectiveness of Transcranial Direct Current Stimulation as an Add-on Modality to Graded Motor Imagery for Treatment of Complex Regional Pain Syndrome: A Randomized Proof of Concept Study. ( 28654557 )
2018
45
Risk Factors for Post-treatment Complex Regional Pain Syndrome (CRPS): An Analysis of 647 Cases of CRPS from the Danish Patient Compensation Association. ( 28691184 )
2018
46
The experiences and beliefs of patients with complex regional pain syndrome: An exploratory survey study. ( 28705011 )
2018
47
Spatially-defined motor deficits in people with unilateral complex regional pain syndrome. ( 28779873 )
2018
48
Prevalence and Cost Analysis of Complex Regional Pain Syndrome (CRPS): A Role for Neuromodulation. ( 28961359 )
2018
49
Transcranial magnetic stimulation studies in complex regional pain syndrome type I: A review. ( 28971481 )
2018
50
Structural and Functional Brain Changes at Early and Late Stages of Complex Regional Pain Syndrome. ( 29038061 )
2018
Sources

Variations for Complex Regional Pain Syndrome

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Expression for Complex Regional Pain Syndrome

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Search GEO for disease gene expression data for Complex Regional Pain Syndrome.
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Pathways for Complex Regional Pain Syndrome

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Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.28 CCL2 HLA-B IL10 IL1B IL6 TNF
2
Human cytomegalovirus infection 37
Show member pathways
 12.98 CCL2 HLA-B IL1B IL6 TNF
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.94 CCL2 IL10 IL1B IL6 TNF
4
Allograft rejection 1 37
Show member pathways
 12.82 HLA-B IL10 IL1B IL6 TNF
5
Influenza A 37
Show member pathways
 12.75 CCL2 HLA-B IL1B IL6 TNF
6
Th17 cell differentiation 37
Show member pathways
 12.54 IL10 IL1B IL6 TNF
7
Immune response IL-23 signaling pathway 22
Show member pathways
 12.54 CCL2 IL10 IL1B IL6 TNF
8
Neuroscience 4
12.53 CALCA NPY SCN9A TOR1A
9
NF-kappaB Signaling 4
12.5 CCL2 IL10 IL1B TNF
10
T cell receptor signaling pathway 37
Show member pathways
 12.39 IL10 IL1B IL6 TNF
11
Selenium Micronutrient Network 1
Show member pathways
 12.3 CCL2 IL1B IL6 TNF
12
IL-17 Family Signaling Pathways 65
Show member pathways
 12.3 CCL2 IL1B IL6 TNF
13
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.22 HLA-B IL10 IL1B IL6 TNF
14
Tuberculosis 37
12.2 IL10 IL1B IL6 TNF
15
IL-1 Family Signaling Pathways 65
Show member pathways
 12.19 EDN1 IL1B IL6 TNF
16
C-type lectin receptor signaling pathway 37
Show member pathways
 12.18 IL10 IL1B IL6 TNF
17
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.13 IL10 IL1B IL6 TAC1 TNF
18
Fluid shear stress and atherosclerosis 37
12.08 CCL2 EDN1 IL1B TNF
19
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.02 CCL2 IL10 IL1B IL6
20
Th1 Differentiation Pathway 65
Show member pathways
 12.02 IL10 IL1B IL6 TNF
21
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.98 IL1B IL6 TNF
22
Spinal Cord Injury 1
11.98 CCL2 IL1B IL6 TNF
23
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.96 IL10 IL6 MME TNF
24
Interleukin-4 and 13 signaling 66
11.91 CCL2 IL10 IL1B IL6 TNF
25
Hematopoietic cell lineage 37
11.87 IL1B IL6 MME TNF
26
TNF signaling pathway 37
11.87 CCL2 EDN1 IL1B IL6 TNF
27
Amoebiasis 37
11.86 IL10 IL1B IL6 TNF
28
Rheumatoid arthritis 37
11.82 CCL2 IL1B IL6 TNF
29
Innate Lymphoid Cell Differentiation Pathways 65
11.76 IL10 IL1B TNF
30
AGE-RAGE signaling pathway in diabetic complications 37
11.76 CCL2 EDN1 IL1B IL6 TNF
31
Pertussis 37
11.73 IL10 IL1B IL6 TNF
32
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.65 IL1B IL6 TNF
33
Dendritic Cells Developmental Lineage Pathway 65
11.59 IL10 IL1B IL6 MME TNF
34
Legionellosis 37
11.57 IL1B IL6 TNF
35
MSP-RON Signaling 64
11.51 CCL2 IL1B TNF
36
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.51 CCL2 IL10 IL1B IL6 TNF
37
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.46 CALCA IL1B IL6 TNF
38
Endothelin Pathways 1
11.35 CALCA EDN1 NPY
39
African trypanosomiasis 37
11.34 IL10 IL1B IL6 TNF
40
IL-10 Pathway 64
11.32 IL10 IL1B IL6 TNF
41
Development and heterogeneity of the ILC family 1
11.31 IL1B IL6 TNF
42
Antifolate resistance 37
11.29 IL1B IL6 TNF
43
Interleukin-10 signaling 66
11.24 CCL2 IL10 IL1B IL6 TNF
44
Cytokines and Inflammatory Response 1
11.17 IL10 IL1B IL6 TNF
45
G-protein signaling_RhoB regulation pathway 22
11.16 CCL2 IL10 IL1B IL6 TNF
46
Cellular roles of Anthrax toxin 1
11.05 IL1B TNF
47
Transcription factor regulation in adipogenesis 1
11.05 IL6 TNF
48
Malaria 37
11.04 CCL2 IL10 IL1B IL6 TNF
49
Overview of nanoparticle effects 1
10.99 IL6 TNF
50
G-protein signaling_Rap2B regulation pathway 22
10.98 CCL2 IL10 IL1B IL6 TNF
Sources

GO Terms for Complex Regional Pain Syndrome

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Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA CCL2 EDN1 IL10 IL1B IL6
2 axon GO:0030424 9.46 CALCA MME SCN9A TAC1
3 extracellular space GO:0005615 9.28 CALCA CCL2 EDN1 IL10 IL1B IL6

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CCL2 HLA-B IL10 IL1B IL6 TNF
2 cell-cell signaling GO:0007267 9.96 CALCA EDN1 IL1B TAC1
3 cytokine-mediated signaling pathway GO:0019221 9.91 CCL2 IL10 IL1B IL6 TNF
4 response to lipopolysaccharide GO:0032496 9.9 EDN1 IL10 IL1B TAC1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 TNF
6 neuron projection development GO:0031175 9.89 IL6 NPY TOR1A
7 cellular response to tumor necrosis factor GO:0071356 9.89 CALCA CCL2 EDN1
8 neuropeptide signaling pathway GO:0007218 9.87 CALCA NPY TAC1
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.87 CALCA EDN1 IL1B TAC1
10 neutrophil chemotaxis GO:0030593 9.86 CCL2 EDN1 IL1B
11 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 IL1B TNF
12 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL6 TNF
13 humoral immune response GO:0006959 9.83 CCL2 IL6 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 EDN1 IL6 TNF
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 EDN1 IL1B TNF
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.79 EDN1 IL10 TNF
17 monocyte chemotaxis GO:0002548 9.79 CALCA CCL2 IL6
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 EDN1 IL1B TNF
19 positive regulation of JUN kinase activity GO:0043507 9.77 EDN1 IL1B TNF
20 protein kinase B signaling GO:0043491 9.73 CCL2 IL1B TNF
21 response to glucocorticoid GO:0051384 9.73 IL10 IL1B IL6 TNF
22 positive regulation of chemokine production GO:0032722 9.72 IL6 TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 CCL2 IL1B TNF
24 cellular response to lipopolysaccharide GO:0071222 9.72 CCL2 IL10 IL1B IL6 TNF
25 response to pain GO:0048265 9.71 CALCA TAC1
26 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
28 positive regulation of interleukin-8 production GO:0032757 9.71 CALCA IL1B TNF
29 regulation of blood pressure GO:0008217 9.71 CALCA EDN1 NPY TAC1
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IL1B TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
32 positive regulation of renal sodium excretion GO:0035815 9.7 EDN1 TAC1
33 negative regulation of bone resorption GO:0045779 9.7 CALCA IL6
34 negative regulation of neurogenesis GO:0050768 9.7 IL1B IL6 TNF
35 positive regulation of acute inflammatory response GO:0002675 9.69 IL6 TAC1
36 response to dexamethasone GO:0071548 9.69 EDN1 IL1B
37 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
38 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
39 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
40 positive regulation of prostaglandin secretion GO:0032308 9.67 EDN1 IL1B
41 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
42 sensory perception of pain GO:0019233 9.67 EDN1 MME SCN9A TAC1
43 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 IL10 TNF
44 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B IL6 TNF
45 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
46 response to ozone GO:0010193 9.64 EDN1 IL1B
47 chronic inflammatory response to antigenic stimulus GO:0002439 9.63 IL1B TNF
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
49 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.43 CALCA CCL2 EDN1 HLA-B NPY TAC1
2 hormone activity GO:0005179 9.33 CALCA EDN1 NPY
3 cytokine activity GO:0005125 9.1 CCL2 EDN1 IL10 IL1B IL6 TNF
Sources

Sources for Complex Regional Pain Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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