CRPS
MCID: CMP010
MIFTS: 59

Complex Regional Pain Syndrome (CRPS)

Categories: Neuronal diseases, Rare diseases, Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Complex Regional Pain Syndrome

MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 11 19 52 58 75 41 14 16
Complex Regional Pain Syndromes 11 53 43 71
Reflex Sympathetic Dystrophy 19 71
Crps 19

Characteristics:


Prevelance:

1-5/10000 (Netherlands) 58

Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:3223
MeSH 43 D020918
SNOMED-CT 68 128200000
MESH via Orphanet 44 D020918
ICD10 via Orphanet 32 G90.5 G90.6
UMLS via Orphanet 72 C0458219
Orphanet 58 ORPHA83452
UMLS 71 C0034931 C0458219

Summaries for Complex Regional Pain Syndrome

NINDS: 52 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary: Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and causalgia, and has symptoms including tremor, back pain and headache. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Signal Transduction and NF-KappaB Family Pathway. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, dorsal root ganglion and spinal cord, and related phenotypes are limb pain and dry skin

MedlinePlus: 41 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are: Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally the symptoms go away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

GARD: 19 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area, skin sensitivity, sweating, and swelling. The underlying cause of CRPS is often not known.

Orphanet: 58 Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.

Wikipedia: 75 Complex regional pain syndrome (CRPS) is any of several painful conditions that are characterized by a... more...

Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 838)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 32.7 TRPV1 TAC1 SCN9A SCN11A NGF CALCA
2 causalgia 32.4 TRPV1 TACR1 TAC1 SCN9A SCN10A NGF
3 chronic pain 31.5 SCN9A P2RX3 OPRM1 BDNF
4 carpal tunnel syndrome 31.2 TAC1 IL6 IL1B
5 radiculopathy 31.0 TAC1 IL6 CALCA
6 common cold 30.8 TNF IL6 IL1B
7 neuroma 30.7 TRPV1 SCN10A NGF IL6 CALCA
8 spinal cord injury 30.7 TNF IL6 BDNF
9 spondyloarthropathy 1 30.6 TNF IL6 IL1B
10 chickenpox 30.6 TNF IL6 IL1B
11 exanthem 30.6 TNF IL6 IL1B
12 post-traumatic stress disorder 30.6 IL6 IL1B BDNF
13 tenosynovitis 30.5 TNF IL6 IL1B
14 chondromalacia 30.5 TNF IL6 IL1B
15 headache 30.5 TNF CALCA BDNF
16 epicondylitis 30.5 TACR1 TAC1 CALCA
17 spondylitis 30.4 TNF IL6 IL1B
18 bone disease 30.4 TNF MIR223 MIR21 IL6 CALCA
19 septic arthritis 30.4 TNF IL6 IL1B
20 rubella 30.4 TNF IL6 IL1B
21 cellulitis 30.4 TNF IL6 IL1B
22 back pain 30.4 IL6 IL1B BDNF
23 ischemia 30.3 TNF MIR21 KNG1 IL6 BDNF
24 motion sickness 30.3 TACR1 TAC1 OPRM1
25 frozen shoulder 30.3 TNF TAC1 IL6 IL1B CALCA
26 proteasome-associated autoinflammatory syndrome 1 30.3 TNF IL6 IL1B
27 lyme disease 30.3 TNF IL6 IL1B
28 leprosy 3 30.3 TNF IL6 IL1B
29 pneumonia 30.3 TNF MIR223 IL6 IL1B
30 keratopathy 30.3 TAC1 NGF IL6 CALCA
31 crohn's disease 30.3 TNF MIR21 IL6 IL1B
32 neuritis 30.2 TNF IL6 IL1B BDNF
33 chronic fatigue syndrome 30.2 TNF IL6 IL1B BDNF
34 cartilage disease 30.2 TNF IL6 IL1B
35 degenerative disc disease 30.2 TNF MIR223 IL1B
36 mononeuropathy 30.2 TRPV1 TNF TAC1 NGF IL6 CALCA
37 spondyloarthropathy 30.2 TNF IL6 IL1B
38 peptic ulcer disease 30.2 TNF IL6 IL1B
39 peripheral artery disease 30.2 TNF MIR21 IL6
40 long covid 30.2 TNF IL6 IL1B
41 angina pectoris 30.2 TNF KNG1 IL6
42 tendinitis 30.1 TNF TAC1 IL6 IL1B
43 spondylosis 30.1 TNF TAC1 IL6 IL1B
44 stroke, ischemic 30.1 TNF MIR21 IL6 IL1B BDNF
45 nerve compression syndrome 30.1 TRPV1 TAC1 NGF IL6 CALCA
46 cryoglobulinemia 30.1 TNF IL6 IL1B
47 urinary tract infection 30.1 TNF IL6 IL1B
48 migraine with aura 30.1 TAC1 SCN9A OPRM1 IL6 CALCA
49 systemic scleroderma 30.1 TNF MIR21 IL6 IL1B
50 paine syndrome 30.1 TRPV1 TRPA1 TNF TACR1 TAC1 SCN9A

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to Complex Regional Pain Syndrome

Symptoms & Phenotypes for Complex Regional Pain Syndrome

Human phenotypes related to Complex Regional Pain Syndrome:

58 30 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 limb pain 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0009763
2 dry skin 58 30 Frequent (33%) Frequent (79-30%)
HP:0000958
3 involuntary movements 58 30 Frequent (33%) Frequent (79-30%)
HP:0004305
4 erythema 58 30 Frequent (33%) Frequent (79-30%)
HP:0010783
5 pedal edema 58 30 Frequent (33%) Frequent (79-30%)
HP:0010741
6 slow-growing nails 58 30 Frequent (33%) Frequent (79-30%)
HP:0008383
7 allodynia 58 30 Frequent (33%) Frequent (79-30%)
HP:0012533
8 edema of the upper limbs 58 30 Frequent (33%) Frequent (79-30%)
HP:0010742
9 trophic changes related to pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0010834
10 abnormality of hair growth 58 30 Frequent (33%) Frequent (79-30%)
HP:0040170
11 dysesthesia 30 Frequent (33%) HP:0012534
12 sensory impairment 58 Frequent (79-30%)
13 hyperalgesia 58 Frequent (79-30%)

UMLS symptoms related to Complex Regional Pain Syndrome:


tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; neuralgia

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.17 BDNF CALCA IL1B IL6 NGF OPRM1
2 behavior/neurological MP:0005386 10.13 BDNF CALCA IL6 KNG1 NGF OPRM1
3 no phenotypic analysis MP:0003012 9.91 BDNF NGF OPRM1 SCN10A TNF TRPA1
4 respiratory system MP:0005388 9.81 BDNF CALCA IL6 MIR223 P2RX3 SCN10A
5 integument MP:0010771 9.5 BDNF CALCA IL1B IL6 NGF OPRM1
6 taste/olfaction MP:0005394 9.26 BDNF SCN9A TRPA1 TRPV1

Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Memantine Approved, Investigational Phase 4 41100-52-1, 19982-08-2 4054
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Ascorbic acid Approved, Nutraceutical Phase 4 50-81-7 54676860 54670067 5785
8 Analgesics Phase 4
9 Neurotransmitter Agents Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Sodium Channel Blockers Phase 4
12 Excitatory Amino Acid Antagonists Phase 4
13 Anesthetics, Local Phase 4
14 Anesthetics Phase 4
15 Diuretics, Potassium Sparing Phase 4
16 Vitamins Phase 4
17 Trace Elements Phase 4
18 Antioxidants Phase 4
19 Micronutrients Phase 4
20 Protective Agents Phase 4
21 Analgesics, Opioid Phase 4
22 Narcotics Phase 4
23 Dopamine Agents Phase 4
24 Antiparkinson Agents Phase 4
25
Triamcinolone hexacetonide Phase 4
26
Triamcinolone diacetate Phase 4
27 Pharmaceutical Solutions Phase 4
28
Triamcinolone Acetonide Phase 4 6436
29 Hormone Antagonists Phase 4
30 Potassium phosphate Phase 4
31 glucocorticoids Phase 4
32
Levobupivacaine Approved, Investigational Phase 3 27262-47-1 92253
33
Zoledronic acid Approved Phase 3 118072-93-8 68740
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
35
Nitrous oxide Approved, Vet_approved Phase 3 10024-97-2 948
36
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 3 55-56-1 2713 9552079
37
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8 5280382 445354
38
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
39 Diphosphonates Phase 3
40 Anesthetics, Intravenous Phase 3
41 Anesthetics, General Phase 3
42 Anesthetics, Inhalation Phase 3
43 Retinol palmitate Phase 3
44 Chlorhexidine gluconate Phase 3
45
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078
46
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
47
Cetuximab Approved Phase 2 205923-56-4
48
Ketamine Approved, Vet_approved Phase 2 6740-88-1, 1867-66-9 3821
49
Lenalidomide Approved Phase 2 191732-72-6 216326
50
Ethosuximide Approved Phase 2 77-67-8 3291

Interventional clinical trials:

(show top 50) (show all 148)
# Name Status NCT ID Phase Drugs
1 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
2 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
3 Restore Claims Characterization Study Completed NCT00200122 Phase 4
4 Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
5 Assessing the Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome - a Feasibility Study Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
6 Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome Completed NCT02467556 Phase 4 Morphine, memantine
7 Peripheral Nerve Injections for the Treatment of Upper Extremity Complex Regional Pain Syndrome: A Feasibility Study for a Proposed Randomized Design Not yet recruiting NCT04744675 Phase 4 Triamcinolone Acetonide 40mg/mL;Saline Injection
8 Double-Blind Randomized Controlled Trial: Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
9 An Analysis of Photoplethysmographic Signal in Diagnostic Lumbar Sympathetic Block for Complex Regional Pain Syndrome Unknown status NCT01134289 Phase 3
10 CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zoledronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Unknown status NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
11 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
12 Acupuncture and Traditional Chinese Medicine Combined With Rehabilitation Therapy for Post-stroke Shoulder-hand Syndrome in Community Hospital: a Multicenter,Randomized,Controlled Trial Unknown status NCT02011854 Phase 2, Phase 3
13 Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I Completed NCT00817128 Phase 2, Phase 3
14 Open-label Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Completed NCT02972359 Phase 3 Neridronic acid
15 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidamide in the Treatment of Complex Regional Pain Syndrome Type1 Completed NCT00166452 Phase 3 Lenalidamide
16 A Randomized, Double-blind Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
17 A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
18 Pilot Study to Evaluate the Effectiveness of a Mixture of Ketamine / Lidocaine Administered by Mesotherapy in the Management of Neuropathic Pain in Complex Regional Pain Syndrome Type 1 (CRPS1). A Monocentric Randomized and Controlled Clinical Study Recruiting NCT04650074 Phase 2, Phase 3 LIDOCAINE 20 mg;LIDOCAINE 20 mg + KETAMINE 20 mg;LIDOCAINE 20 mg + KETAMINE 40 mg
19 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
20 A Prospective Randomized Controlled Pilot Study Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Enrolling by invitation NCT03879538 Phase 3 Nitrous Oxide;Oxygen
21 A Novel Treatment Approach to Complex Regional Pain Syndrome (CRPS): A Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy Not yet recruiting NCT05589259 Phase 3
22 Placebo-controlled Efficacy and Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03560986 Phase 3 Neridronic acid 100 mg;Placebo
23 Randomized, Double-blind, Placebo-controlled Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03530345 Phase 3 Neridronic acid 100 mg;Placebo
24 Prospective, Double-blind, Randomised, Placebo-controlled, Cross-over Study to Investigate the Effect of Intravenous Immunoglobulins on Complex Regional Pain Syndrome (CRPS, M. Sudeck) Withdrawn NCT00949065 Phase 3
25 Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
26 Phase 2 Study - The Use of a Single 5 mg Dose of Zoledronic Acid in Complex Regional Pain Syndrome Patient. Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
27 A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 as an Adjunctive Therapy in Adult Subjects With Chronic Complex Regional Pain Syndrome Completed NCT03990649 Phase 2 Soticlestat;Placebo
28 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
29 A Multicenter, Open-Label Study to Evaluate the Preliminary Safety and Efficacy of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
30 A Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset Complex Regional Pain Syndrome After Total Knee Arthroplasty Completed NCT00558753 Phase 2 pregabalin;Placebo
31 A Randomized, Cross-over, Placebo-controlled, Double-blind, Single-center, Phase II Study of Cetuximab in Patients With Treatment-refractory, Non-malignant Severe Chronic Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
32 CCRC: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
33 Neurotropin for Acute Dental Pain and for Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
34 Randomized Controlled Trial of Subanesthetic Intravenous Ketamine Infusion in Conjunction With Continuous Epidural Infusion for Treatment of Refractory Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
35 A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
36 A Single Centre. Parallel-Group, Double-Blinded, Randomized, Placebo-Controlled Pilot Clinical Trial on Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
37 Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia Withdrawn NCT02987855 Phase 1, Phase 2
38 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
39 Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block: A Prospective Randomized Open-label Trial Unknown status NCT02737527 10 ml of 0.25% levobupivacaine injection for LSB
40 Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes in Individuals With Difficulties in Weight-bearing Unknown status NCT02742376
41 Effects of Repetitive Electric Sensory Stimulation on Sensorimotor Performance and Pain Intensity in Complex Regional Pain Syndrome Type I Unknown status NCT01915329
42 "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" Unknown status NCT03616262 Early Phase 1 Botox + Lidocaine;Lidocaine alone
43 Treatment of Complex Regional Pain Syndrome, a Qualitative Interview Study and a Case Series With Long-term Follow-up Unknown status NCT04597866
44 Identifying Markers of Trajectory in Pediatric Complex Regional Pain Syndrome Unknown status NCT03838107
45 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture, Prospective Double Blind Study Unknown status NCT01338129 placebo
46 Effects of Proprioceptive Stimulation Under Visual Feedback in Patient With CRPS: An Exploratory Study Unknown status NCT02395211
47 EFFECTIVENESS OF GRADED MOTOR IMAGERY TO PREVENT CRPS IN PATIENTS WITH DISTAL RADIUS FRACTURE AFTER SURGERY: A RANDOMIZED CONTROLLED TRIAL Unknown status NCT03937492
48 Comparison of Two Measures of Tactile Acuity in CRPS Type I Patients , Patients With a Neuropathy of the Median Nerve and Healthy Controls. Unknown status NCT01888783
49 Comparison of Methods of Lumbar Sympathetic Ganglion Block: Distance vs Angle Unknown status NCT01648543
50 Distances From Cricoid Cartilage to the Targets of Stellate Ganglion Block Unknown status NCT01601925

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ethanol

Cochrane evidence based reviews: complex regional pain syndromes

Genetic Tests for Complex Regional Pain Syndrome

Anatomical Context for Complex Regional Pain Syndrome

Organs/tissues related to Complex Regional Pain Syndrome:

MalaCards : Skin, Dorsal Root Ganglion, Spinal Cord, Cortex, Bone, Brain, Bone Marrow

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 5647)
# Title Authors PMID Year
1
Parameters of Spinal Cord Stimulation in Complex Regional Pain Syndrome: Systematic Review and Meta-analysis of Randomized Controlled Trials. 62 41
36375180 2022
2
Post-fracture serum cytokine levels are not associated with a later diagnosis of complex regional pain syndrome: a case-control study nested in a prospective cohort study. 62 41
36224537 2022
3
Combining Stellate ganglion block and intravenous regional anesthesia to treat complex regional pain syndrome: A 19-years' experience in a tertiary center. 62 41
36261198 2022
4
Pharmacotherapy options for complex regional pain syndrome. 53 62
17492902 2007
5
Efficacy of salmon calcitonin in complex regional pain syndrome (type 1) in addition to physical therapy. 53 62
15980934 2006
6
[Experiences with calcitonin treatment of patients with type I complex regional pain syndrome (CRPS I--Sudeck disease)]. 53 62
11605299 2001
7
Assessing spatial connectivity effects on daily streamflow forecasting using Bayesian-based graph neural network. 62
36162576 2023
8
Bioreduction mechanisms of high-concentration hexavalent chromium using sulfur salts by photosynthetic bacteria. 62
36243096 2023
9
Dorsal bridging plates for the treatment of high and low energy distal radius fractures. 62
36340961 2022
10
Cholesterol-binding sequence is a key regulatory motif of cellular folding and conformational activation for C-reactive protein. 62
36334345 2022
11
[Electrotherapeutical stellate ganglion block on a patient with complex regional pain syndrome of the upper limb]. 62
36459205 2022
12
Successful Multimodal Treatment for Complex Regional Pain Syndrome in an Adolescent with Acute Lymphoblastic Leukemia: A Case Report. 62
34936831 2022
13
Autoantibodies from patients with complex regional pain syndrome induce pro-inflammatory effects and functional disturbances on endothelial cells in vitro. 62
35384930 2022
14
Nociception level index variations in patients with complex regional pain syndrome: a pilot study. 62
35260985 2022
15
The Language of Pain: Is There a Relationship Between Metaphor Use and Adjustment to Chronic Pain? 62
33729513 2022
16
Intravenous Lidocaine in Chronic Neuropathic Pain: A Systematic Review. 62
36288104 2022
17
Techniques for Safe Removal of Spinal Cord Stimulation Paddle Leads. 62
36227247 2022
18
[Less invasive turn-down flap tendinoplasty in chronic Achilles tendon rupture]. 62
36036248 2022
19
Chronic Pain Considerations in Patients with Cardiovascular Disease. 62
36328629 2022
20
[Surgical treatment of calcifying insertional Achilles tendinopathy via a lateral approach]. 62
36342529 2022
21
The epidemiology of dystonia: the Hannover epidemiology study. 62
35948800 2022
22
Complications and Functional Outcomes following Trigger Finger Release: A Cohort Study of 1879 Patients. 62
35994343 2022
23
Peripheral Nerve Stimulation in Painful Conditions of the Upper Extremity-An Overview. 62
36359295 2022
24
Use of Hand Therapy After Distal Radius Fracture: A National Perspective. 62
34666936 2022
25
Reciprocal interaction of pain and brain: Plasticity-induced pain, pain-induced plasticity, and therapeutic targets. 62
36330624 2022
26
Dorsal Root Ganglion Stimulation for the Treatment of Joint Pain with Predominantly Nociceptive Characteristics: A Case Series. 62
36334041 2022
27
A modified three-incision approach to treating three-column Lisfranc injuries. 62
35985903 2022
28
A novel distractor-assisted reduction combined with the sinus tarsi approach for joint depression-type calcaneal fractures. 62
36370163 2022
29
Molecular and clinical markers of pain relief in complex regional pain syndrome: An observational study. 62
36440973 2022
30
Efficacy and Safety of Cervical and High-Thoracic Dorsal Root Ganglion Stimulation Therapy for Complex Regional Pain Syndrome of the Upper Extremities. 62
36402657 2022
31
Clinical practice guidelines for the management of patients with complex regional pain syndrome: a systematic appraisal using the AGREE II instrument. 62
36193759 2022
32
Reporting of Interventions for Treating Complex Regional Pain Syndrome in Randomized Controlled Trials Using the Template for Intervention Description and Replication Checklist. 62
36342209 2022
33
Amputation for Complex Regional Pain Syndrome: Meta-Analysis and Validation of a Histopathology Scoring System. 62
36355456 2022
34
Cervical dorsal root ganglion stimulation for complex regional pain syndrome: Technical description and results of seven cases. 62
36380700 2022
35
Olfaction in complex regional pain syndrome. 62
36409035 2022
36
Glucocorticoid treatment in patients with complex regional pain syndrome: A systematic review. 62
35983980 2022
37
Assessment of body perception disturbances in complex regional pain syndrome: A systematic review using the COSMIN guideline. 62
36065635 2022
38
Long-term Outcomes in Use of Opioids, Nonpharmacologic Pain Interventions, and Total Costs of Spinal Cord Stimulators Compared With Conventional Medical Therapy for Chronic Pain. 62
36441532 2022
39
Postoperative Imaging of the Wrist and Hand. 62
36243510 2022
40
Pharmacologic Treatments in Upper Extremity Complex Regional Pain Syndrome: A Review and Analysis of Quality of Evidence. 62
36424817 2022
41
Multiomics Profiling of Toxins in the Venom of the Amazonian Spider Acanthoscurria juruenicola. 62
36260604 2022
42
Insights into the role of complement regulatory proteins in HPV mediated cervical carcinogenesis. 62
34087416 2022
43
LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo-Inspired pH/Tactility Artificial Receptors. 62
36377355 2022
44
Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume. 62
36270560 2022
45
BONE-360: a new app to diagnose CRPS type 1. 62
36475536 2022
46
Photoluminescence Path Bifurcations by Spin Flip in Two-Dimensional CrPS4. 62
36129115 2022
47
The Role of C-reactive Protein Estimation in Determining the Duration of Antibiotic Therapy in Neonatal Sepsis. 62
36246087 2022
48
Recent Trends in Medicare Utilization and Reimbursement for Spinal Cord Stimulators: 2000-2019. 62
35872133 2022
49
A five-year retrospective cohort study of carpal tunnel surgery complications in an Australian population. 62
36203391 2022
50
Complex regional pain syndrome of the foot and ankle following knee arthroscopy. 62
36322439 2022

Variations for Complex Regional Pain Syndrome

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1 13.71 TNF TACR1 TAC1 OPRM1 NGF KNG1
2
Show member pathways
12.62 TNF NGF IL6 IL1B BDNF
3
Show member pathways
12.5 TACR1 TAC1 SCN9A SCN11A SCN10A BDNF
4 12.38 CALCA NGF OPRM1 SCN10A SCN11A SCN9A
5 12.33 TNF NGF IL1B BDNF
6 11.87 TNF NGF IL6 IL1B BDNF
7 11.79 TNF OPRM1 IL6 IL1B
8 11.68 TNF IL6 IL1B
9 11.67 TNF IL6 IL1B
10 11.61 TNF TACR1 IL6 IL1B BDNF
11
Show member pathways
11.6 TNF IL6 IL1B
12 11.58 TNF MIR21 IL6
13 11.57 TNF IL6 IL1B
14 11.5 NGF IL6 BDNF
15 11.5 TNF IL6 IL1B CALCA
16 11.42 TNF IL6 IL1B
17 11.37 TNF TACR1 TAC1 NGF IL6 IL1B
18 11.28 TNF IL6 IL1B
19 11.26 SCN9A SCN11A SCN10A
20 11.22 IL1B IL6 TNF
21 11.21 TNF IL6 IL1B CALCA
22 11.19 SCN9A SCN11A SCN10A
23 11.16 TNF IL6 IL1B
24 11.13 TNF IL6 IL1B
25 11.1 TNF IL6 IL1B
26 10.95 TNF NGF IL6 IL1B BDNF
27 10.73 IL6 IL1B
28 10.46 TAC1 TACR1
29 10.28 TACR1 TAC1
30 10.04 TRPV1 TRPA1
31
Show member pathways
9.83 TNF KNG1 IL6

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.34 TRPV1 TRPA1 TNF TACR1 SCN9A P2RX3
2 plasma membrane GO:0005887 10.34 TRPV1 TRPA1 TNF TACR1 SCN9A P2RX3
3 neuronal cell body GO:0043025 9.9 CALCA P2RX3 SCN11A TAC1 TNF TRPV1
4 axon GO:0030424 9.53 TAC1 SCN9A SCN11A SCN10A P2RX3 OPRM1
5 obsolete integral component of presynaptic membrane GO:0099056 9.43 SCN10A P2RX3 OPRM1
6 voltage-gated sodium channel complex GO:0001518 9.43 SCN9A SCN11A SCN10A

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.36 TNF OPRM1 NGF MIR21 IL6 IL1B
2 calcium ion transmembrane transport GO:0070588 10.22 TRPV1 TRPA1 SCN11A OPRM1
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 10.21 BDNF IL6 NGF TNF
4 monoatomic ion transport GO:0006811 10.19 TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3
5 inflammatory response GO:0006954 10.19 CALCA IL1B IL6 KNG1 SCN9A TAC1
6 regulation of insulin secretion GO:0050796 10.17 TNF IL6 IL1B
7 positive regulation of cytosolic calcium ion concentration GO:0007204 10.17 CALCA KNG1 OPRM1 TAC1 TACR1 TRPV1
8 response to cold GO:0009409 10.16 TRPA1 SCN9A P2RX3
9 cellular response to lipopolysaccharide GO:0071222 10.14 TNF MIR223 MIR21 IL6 IL1B
10 cellular response to nerve growth factor stimulus GO:1990090 10.13 TRPV1 TAC1 CALCA
11 positive regulation of interleukin-8 production GO:0032757 10.11 TNF IL6 IL1B CALCA
12 positive regulation of chemokine production GO:0032722 10.09 TNF IL6 IL1B
13 negative regulation of neurogenesis GO:0050768 10.09 TNF IL6 IL1B
14 embryo implantation GO:0007566 10.08 MIR21 IL1B CALCA
15 neuronal action potential GO:0019228 10.08 SCN9A SCN11A SCN10A P2RX3
16 vasodilation GO:0042311 10.07 TNF KNG1 CALCA
17 positive regulation of glial cell proliferation GO:0060252 10.06 IL1B IL6 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 10.05 TRPV1 TNF OPRM1 IL1B
19 membrane depolarization during action potential GO:0086010 10.03 SCN9A SCN11A SCN10A
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.02 TNF MIR21 IL6
21 positive regulation of neuroinflammatory response GO:0150078 10 IL1B IL6 TNF
22 positive regulation of action potential GO:0045760 9.99 TNF TACR1
23 acute inflammatory response GO:0002526 9.99 TNF TACR1 SCN11A
24 positive regulation of fever generation GO:0031622 9.98 IL1B TNF
25 monoatomic ion transmembrane transport GO:0034220 9.97 TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3
26 detection of abiotic stimulus GO:0009582 9.96 TAC1 TACR1
27 sequestering of triglyceride GO:0030730 9.96 IL1B TNF
28 thermoception GO:0050955 9.96 TRPA1 TRPV1
29 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.95 TRPA1 TNF SCN11A
30 fever generation GO:0001660 9.94 IL1B TRPV1
31 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.94 TRPA1 TRPV1
32 smooth muscle contraction involved in micturition GO:0060083 9.93 TACR1 TRPV1
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.93 IL1B TNF
34 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.93 TNF MIR21 IL6
35 vascular endothelial growth factor production GO:0010573 9.93 TNF IL6 IL1B
36 monoatomic cation transmembrane transport GO:0098655 9.88 SCN9A SCN11A SCN10A P2RX3
37 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.87 MIR21 IL6
38 urinary bladder smooth muscle contraction GO:0014832 9.86 TRPV1 P2RX3
39 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.85 TRPV1 SCN9A SCN11A CALCA
40 response to heat GO:0009408 9.85 TRPV1 TACR1 SCN9A SCN11A P2RX3 CALCA
41 behavioral response to formalin induced pain GO:0061368 9.8 SCN9A SCN11A P2RX3
42 behavioral response to pain GO:0048266 9.8 TRPV1 TACR1 SCN9A P2RX3
43 calcitonin gene-related peptide receptor signaling pathway GO:1990408 9.62 CALCA SCN11A
44 response to pain GO:0048265 9.56 TRPV1 TRPA1 TACR1 TAC1 CALCA
45 sensory perception of pain GO:0019233 9.44 TRPV1 TRPA1 TACR1 TAC1 SCN9A SCN10A

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.87 TNF NGF KNG1 IL6 CALCA BDNF
2 voltage-gated sodium channel activity GO:0005248 9.73 SCN9A SCN11A SCN10A
3 nerve growth factor receptor binding GO:0005163 9.67 NGF BDNF
4 sodium channel activity GO:0005272 9.33 SCN9A SCN11A SCN10A
5 monoatomic cation channel activity GO:0005261 9.26 TRPV1 SCN9A SCN11A SCN10A
6 monoatomic ion channel activity GO:0005216 9.17 TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3

Sources for Complex Regional Pain Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....