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MCID: CMP010
MIFTS: 63

Complex Regional Pain Syndrome

Categories: Neuronal diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Complex Regional Pain Syndrome

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MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 77 54 55 44 15 17
Complex Regional Pain Syndromes 12 56 45 74
Reflex Sympathetic Dystrophy 54 74
Crps 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Complex Regional Pain Syndrome

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NINDS : 55 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to reflex sympathetic dystrophy and causalgia, and has symptoms including seizures, tremor and back pain. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and bone, and related phenotypes are limb pain and dry skin

NIH Rare Diseases : 54 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is often not known. Two classifications of CRPS have been recognized based on causalgia. Type I (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and Type II, in which peripheral nerve injury is present. Treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy; and/or a sympathetic nerve block.

MedlinePlus : 44 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally the symptoms go away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a disorder... more...

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Related Diseases for Complex Regional Pain Syndrome

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Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 611)
# Related Disease Score Top Affiliating Genes
1 reflex sympathetic dystrophy 33.9 CALCA NPY
2 causalgia 33.4 CALCA NPY TAC1
3 autonomic nervous system disease 31.7 CALCA NPY TAC1
4 peripheral nervous system disease 31.2 IL6 SCN9A TAC1 TNF
5 vulvar vestibulitis syndrome 30.5 IL1B TNF
6 periodontal disease 30.5 IL1B IL6 TNF
7 periodontitis, chronic 30.4 IL1B IL6
8 osteoarthritis 30.3 IL1B IL6 TNF
9 haemophilus influenzae 30.3 IL1B TNF
10 fatty liver disease 30.3 IL1B IL6 TNF
11 arthritis 30.2 IL10 IL1B IL6 TNF
12 cystitis 30.2 IL6 TAC1 TNF
13 burns 30.2 IL1B TNF
14 osteoporosis 30.2 CALCA IL1B IL6 TNF
15 pneumonia 30.2 IL10 IL1B IL6 TNF
16 spondylitis 30.2 HLA-B IL6 TNF
17 interstitial cystitis 30.2 ADRB2 IL6 TAC1
18 appendicitis 30.1 IL10 IL1B IL6 TNF
19 irritable bowel syndrome 30.1 IL10 TAC1 TNF
20 periodontitis 30.1 IL10 IL1B IL6 TNF
21 spondyloarthropathy 30.1 HLA-B IL10 IL6 TNF
22 pulmonary disease, chronic obstructive 30.1 ADRB2 IL6 TNF
23 carpal tunnel syndrome 30.1 IL1B IL6 TAC1
24 ulcerative colitis 30.0 IL10 IL1B IL6 TNF
25 colitis 30.0 IL10 IL1B IL6 TNF
26 meningitis 30.0 IL10 IL1B IL6 TNF
27 arteries, anomalies of 30.0 EDN1 IL1B IL6 TNF
28 anterior uveitis 30.0 HLA-B IL6
29 migraine with or without aura 1 30.0 CALCA TAC1 TNF
30 endocarditis 29.9 IL10 IL6 TNF
31 rheumatoid arthritis 29.9 HLA-B IL10 IL1B IL6 TNF
32 inflammatory bowel disease 29.9 IL10 IL1B IL6 TNF
33 heart disease 29.8 EDN1 IL10 IL1B IL6 TNF
34 rubella 29.8 HLA-B IL10 TNF
35 lyme disease 29.8 IL1B IL6 TNF
36 chorioamnionitis 29.8 IL1B IL6 TNF
37 peritonitis 29.8 IL10 IL1B IL6 TNF
38 cholangitis 29.8 HLA-B IL6 TNF
39 bacterial sepsis 29.8 CALCA IL10 TNF
40 uveitis 29.8 HLA-B IL10 TNF
41 kawasaki disease 29.7 IL10 IL6 TNF
42 periapical periodontitis 29.7 IL1B IL6 TNF
43 bacterial infectious disease 29.7 IL10 IL1B IL6 TNF
44 autoimmune disease 29.7 IL10 IL1B IL6 TNF
45 chronic fatigue syndrome 29.7 IL10 IL1B IL6 TNF
46 chlamydia 29.7 IL10 IL1B IL6 TNF
47 typhoid fever 29.6 IL1B IL6 TNF
48 takayasu arteritis 29.6 HLA-B IL6 TNF
49 peptic ulcer disease 29.6 IL10 IL1B TNF
50 psoriatic arthritis 29.6 HLA-B IL1B IL6 TNF

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:



Diseases related to Complex Regional Pain Syndrome
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Symptoms & Phenotypes for Complex Regional Pain Syndrome

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Human phenotypes related to Complex Regional Pain Syndrome:

33 (show all 11)
# Description HPO Frequency HPO Source Accession
1 limb pain 33 hallmark (90%) HP:0009763
2 dry skin 33 frequent (33%) HP:0000958
3 erythema 33 frequent (33%) HP:0010783
4 involuntary movements 33 frequent (33%) HP:0004305
5 slow-growing nails 33 frequent (33%) HP:0008383
6 allodynia 33 frequent (33%) HP:0012533
7 edema of the upper limbs 33 frequent (33%) HP:0010742
8 trophic changes related to pain 33 frequent (33%) HP:0010834
9 hyperalgesia 33 frequent (33%) HP:0031005
10 abnormality of hair growth 33 frequent (33%) HP:0040170
11 pedal edema 33 frequent (33%) HP:0010741

UMLS symptoms related to Complex Regional Pain Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 ADRA1A ADRB2 EDN1 IL10 IL1B IL6
2 integument MP:0010771 9.8 IL10 IL1B IL6 MME SCN9A TAC1
3 muscle MP:0005369 9.63 ADRA1A ADRB2 EDN1 IL10 IL6 TNF
4 renal/urinary system MP:0005367 9.43 ADRA1A EDN1 IL6 NPY SCN9A TAC1
5 skeleton MP:0005390 9.17 ADRB2 EDN1 IL10 IL1B IL6 NPY
Sources

Drugs & Therapeutics for Complex Regional Pain Syndrome

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Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 154)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 38396-39-3, 2180-92-9 2474
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
3
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
4
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
5
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
6
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 54670067 5785
7
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
8
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
9 Vitamins Phase 4,Phase 3,Not Applicable
10 Trace Elements Phase 4,Phase 3,Not Applicable
11 Protective Agents Phase 4,Phase 3,Not Applicable
12 Antioxidants Phase 4,Phase 3,Not Applicable
13 Micronutrients Phase 4,Phase 3,Not Applicable
14 Nutrients Phase 4,Phase 3,Not Applicable
15 Triamcinolone diacetate Phase 4,Phase 3,Not Applicable
16 Triamcinolone hexacetonide Phase 4,Phase 3,Not Applicable
17 triamcinolone acetonide Phase 4,Phase 3,Not Applicable
18 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Anesthetics, Local Phase 4,Phase 3,Not Applicable,Early Phase 1
22 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
25 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
26 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
27 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
28 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Not Applicable
29 Anticonvulsants Phase 4,Phase 2,Not Applicable
30 Diuretics, Potassium Sparing Phase 4,Not Applicable,Early Phase 1
31 Sodium Channel Blockers Phase 4,Not Applicable,Early Phase 1
32 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
33 Antimanic Agents Phase 4,Not Applicable
34 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
35 Anti-Anxiety Agents Phase 4,Phase 2,Not Applicable
36 Vasodilator Agents Phase 4,Phase 2
37 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
38 Katacalcin Phase 4
39 calcitonin Phase 4
40
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 175805 71273
41
Levobupivacaine Approved, Investigational Phase 3,Not Applicable 27262-47-1 92253
42
Zoledronic Acid Approved Phase 3,Phase 2 118072-93-8 68740
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3,Not Applicable 437-38-7 3345
44
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
45
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
46
Sodium Citrate Approved, Investigational Phase 3 68-04-2
47
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
48
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
49
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
50
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 145)
# Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
3 Restore Claims Characterization Study Completed NCT00200122 Phase 4
4 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
6 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
7 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
8 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
9 (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes Not yet recruiting NCT03796195 Phase 4 .5% Bupivacaine
10 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
11 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
12 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
13 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
14 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
15 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
16 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
17 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
18 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
19 Safety of Intravenous Neridronic Acid in CRPS Completed NCT02972359 Phase 3 Neridronic acid
20 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
21 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
22 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
23 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
24 Efficacy and Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT03530345 Phase 3 Neridronic acid;Placebo
25 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
26 Soft Part Management for Surgical Fractures of the Lower Limb Not yet recruiting NCT03915223 Phase 3 Solumedrol (steroidal anti-inflammatory drug)
27 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
28 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
29 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
30 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
31 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
32 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
33 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
34 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
35 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
36 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
37 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
38 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Enrolling by invitation NCT02987855 Phase 1, Phase 2
39 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
40 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
41 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
42 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
43 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
44 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
45 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
46 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329 Not Applicable
47 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 Not Applicable placebo
48 Effects of Proprioceptive Stimulation Under Visual Feedback in Patient With CRPS Unknown status NCT02395211 Not Applicable
49 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715 Not Applicable
50 Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes Unknown status NCT02742376 Not Applicable

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: complex regional pain syndromes

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Genetic Tests for Complex Regional Pain Syndrome

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Anatomical Context for Complex Regional Pain Syndrome

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MalaCards organs/tissues related to Complex Regional Pain Syndrome:

42
Skin, Spinal Cord, Bone, Cortex, Heart, Testes, Brain
Sources

Publications for Complex Regional Pain Syndrome

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Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 1633)
# Title Authors Year
1
Sensory disturbances induced by sensorimotor conflicts are higher in complex regional pain syndrome and fibromyalgia compared to arthritis and healthy people, and positively relate to pain intensity. ( 30288850 )
2019
2
The Role of Additional Spine Surgery in the Management of Failed Back Surgery Syndrome, Complex Regional Pain Syndrome, and Intractable Pain in the Setting of Previous or Concurrent Spinal Cord Stimulation: Indications and Outcomes. ( 30703586 )
2019
3
Differences in Neuronal Representation of Mental Rotation in Patients With Complex Regional Pain Syndrome and Healthy Controls. ( 30710707 )
2019
4
Sex matters in complex regional pain syndrome. ( 30735277 )
2019
5
Compared to limb pain of other origin, ultrasonographic osteodensitometry reveals loss of bone density in complex regional pain syndrome. ( 30747906 )
2019
6
Comparison of complex regional pain syndrome and fibromyalgia: Differences in beta and gamma bands on quantitative electroencephalography. ( 30762759 )
2019
7
Clinical Course and Impact of Complex Regional Pain Syndrome Confined to the Knee. ( 30776297 )
2019
8
Complex regional pain syndrome secondary to everolimus: two cases. ( 30776491 )
2019
9
Evaluation Through Transcutaneous Tissue Oximetry (Near Infrared Spectroscopy) of Spinal Cord Stimulation in Patients With Complex Regional Pain Syndrome Type I. ( 30786089 )
2019
10
Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema. ( 30801357 )
2019
11
Commentary: Selective Fiber Degeneration in the Peripheral Nerve of a Patient With Severe Complex Regional Pain Syndrome. ( 30804734 )
2019
12
Direct Health Care Cost and Work Incapacity Related to Complex Regional Pain Syndrome in Switzerland: A Retrospective Analysis from 2008 to 2015. ( 30848817 )
2019
13
Psychosocial factors associated with poor outcomes after amputation for complex regional pain syndrome type-I. ( 30865687 )
2019
14
Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange. ( 30871575 )
2019
15
Increased cerebral nuclear factor kappa B in a complex regional pain syndrome rat model: possible relationship between peripheral injury and the brain. ( 30881100 )
2019
16
Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. ( 30885223 )
2019
17
Incidence of and Risk Factors for Complex Regional Pain Syndrome Type 1 after Surgery for Distal Radius Fractures: A Population-based Study. ( 30890732 )
2019
18
Dramatic effect in passive ROM exercise under sedation in a patient with intractable complex regional pain syndrome (type I): A case report. ( 30921212 )
2019
19
Longitudinal TSPO-PET imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome. ( 31095093 )
2019
20
What is normal trauma healing, what is Complex Regional Pain Syndrome I? An analysis of clinical and experimental biomarkers. ( 31095096 )
2019
21
Complex regional pain syndrome: a focus on the autonomic nervous system. ( 31104164 )
2019
22
TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1. ( 31105572 )
2019
23
Single S1 Dorsal Root Ganglia Stimulation for Intractable Complex Regional Pain Syndrome Foot Pain After Lumbar Spine Surgery: A Case Series. ( 29701900 )
2019
24
Pharmacotherapeutic options for complex regional pain syndrome. ( 31063415 )
2019
25
Ozone Therapy for Complex Regional Pain Syndrome: Review and Case Report. ( 31062104 )
2019
26
Complex regional pain syndrome: a narrative review for the practicing clinician. ( 31056241 )
2019
27
Sympathetic blocks for complex regional pain syndrome: a survey of pain physicians. ( 31055496 )
2019
28
Erratum to "Complex regional pain Syndrome" [Man. Ther. 26C (2016) 223-230]. ( 31053563 )
2019
29
Complex Regional Pain Syndrome (Sudeck Atrophy) Prevention Possibility and Accelerated Recovery in Patients with Distal Radius at the Typical Site Fracture Using Polarized, Polychromatic Light Therapy. ( 31050956 )
2019
30
Robot-assisted line bisection in patients with Complex Regional Pain Syndrome. ( 31048861 )
2019
31
Physical therapy in patients with complex regional pain syndrome type I after distal radius fracture: a case series. ( 31037018 )
2019
32
The Efficacy of Vitamin C in the Prevention of Complex Regional Pain Syndrome After Distal Radius Fractures: A Synthesis. ( 30998426 )
2019
33
Prognostic Factors in Complex Regional Pain Syndrome Type 1 Occurring in the Korean Army. ( 30986307 )
2019
34
Parallels between lumbosacral radiculopathy and complex regional pain syndrome: α1-adrenoceptor upregulation, reduced dermal nerve fibre density and hemi-sensory disturbances in post-surgical sciatica. ( 30950911 )
2019
35
Correction to: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. ( 30943989 )
2019
36
The Effectiveness of Fluidotherapy in Poststroke Complex Regional Pain Syndrome: A Randomized Controlled Study. ( 30940426 )
2019
37
Long-term Outcomes Using Intrathecal Drug Delivery Systems in Complex Regional Pain Syndrome. ( 29889241 )
2019
38
Updated guidelines on complex regional pain syndrome in adults✰. ( 30268742 )
2019
39
Short-Term Glucocorticoid Treatment Normalizes the Microcirculatory Response to Remote Ischemic Conditioning in Early Complex Regional Pain Syndrome. ( 30269438 )
2019
40
Altered tactile localization and spatiotemporal integration in complex regional pain syndrome patients. ( 30288852 )
2019
41
Dorsal Scapular Neuropathy as a Rare Cause 1 of Complex Regional Pain Syndrome: A Reappraisal on Ultrasound Imaging and Guidance for Recalcitrant Pain. ( 30300234 )
2019
42
Complex regional pain syndrome and functional neurological disorders - time for reconciliation. ( 30355604 )
2019
43
High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Complex Regional Pain Syndrome: A Case Series of Patients With or Without Previous Spinal Cord Stimulator Implantation. ( 30365222 )
2019
44
Neurometabolite changes in patients with complex regional pain syndrome using magnetic resonance spectroscopy: a pilot study. ( 30507760 )
2019
45
Perfusion index as a tool to evaluate the efficacy of stellate ganglion block for complex regional pain syndrome. ( 30600407 )
2019
46
Standards for the diagnosis and management of complex regional pain syndrome: Results of a European Pain Federation task force. ( 30620109 )
2019
47
Spinal cord stimulation for complex regional pain syndrome type I with spinal myoclonus - a case report and review of literature. ( 30636459 )
2019
48
Complex regional pain syndrome - False hopes and miscommunications. ( 30639650 )
2019
49
Priapism following erector spinae plane block for the treatment of a complex regional pain syndrome. ( 30660341 )
2019
50
Intra-articular botulinum toxin injection in complex regional pain syndrome: Case report and review of the literature. ( 30660558 )
2019
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Variations for Complex Regional Pain Syndrome

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Expression for Complex Regional Pain Syndrome

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Search GEO for disease gene expression data for Complex Regional Pain Syndrome.
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Pathways for Complex Regional Pain Syndrome

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Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 38 1
Show member pathways
 12.8 HLA-B IL10 IL1B IL6 TNF
2
Th17 cell differentiation 38
Show member pathways
 12.51 IL10 IL1B IL6 TNF
3
Immune response IL-23 signaling pathway 23
Show member pathways
 12.5 IL10 IL1B IL6 TNF
4
Neuroscience 4
12.5 ADRB2 CALCA NPY SCN9A
5
T cell receptor signaling pathway 38
Show member pathways
 12.49 IL10 IL1B IL6 TNF
6
Myometrial Relaxation and Contraction Pathways 1
Show member pathways
 12.48 ADRA1A ADRB2 CALCA IL1B IL6
7
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.21 HLA-B IL10 IL1B IL6 TNF
8
Tuberculosis 38
12.19 IL10 IL1B IL6 TNF
9
IL-1 Family Signaling Pathways 66
Show member pathways
 12.17 EDN1 IL1B IL6 TNF
10
C-type lectin receptor signaling pathway 38
Show member pathways
 12.16 IL10 IL1B IL6 TNF
11
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.09 IL10 IL1B IL6 TAC1 TNF
12
Fluid shear stress and atherosclerosis 38
12.01 EDN1 IL1B TNF
13
Th1 Differentiation Pathway 66
Show member pathways
 12.01 IL10 IL1B IL6 TNF
14
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.96 IL1B IL6 TNF
15
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.95 IL10 IL6 MME TNF
16
Spinal Cord Injury 1
11.93 IL1B IL6 TNF
17
Interleukin-4 and 13 signaling 67
11.93 IL10 IL1B IL6 TNF
18
TNF signaling pathway 38
11.91 EDN1 IL1B IL6 TNF
19
AGE-RAGE signaling pathway in diabetic complications 38
11.85 EDN1 IL1B IL6 TNF
20
Hematopoietic cell lineage 38
11.82 IL1B IL6 MME TNF
21
Amoebiasis 38
11.81 IL10 IL1B IL6 TNF
22
Rheumatoid arthritis 38
11.8 IL1B IL6 TNF
23
Innate Lymphoid Cell Differentiation Pathways 66
11.73 IL10 IL1B TNF
24
Pertussis 38
11.69 IL10 IL1B IL6 TNF
25
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.65 IL10 IL1B IL6 TNF
26
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.62 IL1B IL6 TNF
27
Legionellosis 38
11.56 IL1B IL6 TNF
28
Interleukin-10 signaling 67
11.45 IL10 IL1B IL6 TNF
29
Malaria 38
11.42 IL10 IL1B IL6 TNF
30
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.36 CALCA IL1B IL6 TNF
31
Development and heterogeneity of the ILC family 1
11.3 IL1B IL6 TNF
32
Antifolate resistance 38
11.28 IL1B IL6 TNF
33
African trypanosomiasis 38
11.24 IL10 IL1B IL6 TNF
34
Dendritic Cells Developmental Lineage Pathway 66
11.22 IL10 IL1B IL6 MME TNF
35
G-protein signaling_RhoB regulation pathway 23
11.17 IL10 IL1B IL6 TNF
36
IL-10 Pathway 65
11.17 IL10 IL1B IL6 TNF
37
Sympathetic Nerve Pathway (Neuroeffector Junction) 62
11.1 ADRA1A ADRB2 NPY
38
Endothelin Pathways 1
11.09 ADRA1A CALCA EDN1 NPY
39
Cellular roles of Anthrax toxin 1
11.04 IL1B TNF
40
Transcription factor regulation in adipogenesis 1
11.03 IL6 TNF
41
Overview of nanoparticle effects 1
10.96 IL6 TNF
42
Cytokines and Inflammatory Response 1
10.92 IL10 IL1B IL6 TNF
43
LDL Oxidation in Atherogenesis 65
10.88 IL1B TNF
44
Lung fibrosis 1
10.82 CALCA EDN1 IL1B IL6 TNF
Sources

GO Terms for Complex Regional Pain Syndrome

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Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 ADRA1A ADRB2 HLA-B MME SCN9A TNF
2 extracellular region GO:0005576 9.56 CALCA EDN1 IL10 IL1B IL6 NPY
3 axon GO:0030424 9.43 MME SCN9A TAC1
4 extracellular space GO:0005615 9.23 CALCA EDN1 IL10 IL1B IL6 NPY

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 IL10 IL1B IL6 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TNF
3 positive regulation of MAPK cascade GO:0043410 9.89 ADRA1A ADRB2 IL6
4 response to lipopolysaccharide GO:0032496 9.88 EDN1 IL10 IL1B TAC1
5 cell-cell signaling GO:0007267 9.88 ADRA1A CALCA EDN1 IL1B TAC1
6 cellular response to lipopolysaccharide GO:0071222 9.87 IL10 IL1B IL6 TNF
7 response to drug GO:0042493 9.86 ADRA1A EDN1 IL10
8 positive regulation of interleukin-6 production GO:0032755 9.82 IL1B IL6 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 EDN1 IL6 TNF
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 EDN1 IL1B TNF
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 EDN1 IL10 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 EDN1 IL1B TNF
13 regulation of vasoconstriction GO:0019229 9.73 ADRA1A EDN1
14 positive regulation of heart rate GO:0010460 9.73 ADRA1A EDN1
15 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.72 ADRA1A ADRB2
16 positive regulation of chemokine production GO:0032722 9.72 IL6 TNF
17 positive regulation of smooth muscle contraction GO:0045987 9.72 ADRA1A EDN1
18 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
21 regulation of blood pressure GO:0008217 9.71 CALCA EDN1 NPY TAC1
22 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
23 positive regulation of renal sodium excretion GO:0035815 9.7 EDN1 TAC1
24 negative regulation of bone resorption GO:0045779 9.7 CALCA IL6
25 neuropeptide signaling pathway GO:0007218 9.7 NPY TAC1
26 positive regulation of interleukin-8 production GO:0032757 9.7 CALCA IL1B TNF
27 positive regulation of acute inflammatory response GO:0002675 9.69 IL6 TAC1
28 positive regulation of synaptic transmission, GABAergic GO:0032230 9.69 ADRA1A TAC1
29 negative regulation of neurogenesis GO:0050768 9.69 IL1B IL6 TNF
30 adrenergic receptor signaling pathway GO:0071875 9.68 ADRA1A ADRB2
31 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
32 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
33 positive regulation of glial cell proliferation GO:0060252 9.67 IL1B IL6 TNF
34 sensory perception of pain GO:0019233 9.67 EDN1 MME SCN9A TAC1
35 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
36 positive regulation of prostaglandin secretion GO:0032308 9.66 EDN1 IL1B
37 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
39 positive regulation of action potential GO:0045760 9.63 ADRA1A TAC1
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
41 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
42 positive regulation of cytosolic calcium ion concentration GO:0007204 9.62 ADRA1A CALCA EDN1 TAC1
43 response to glucocorticoid GO:0051384 9.61 IL10 IL6 TNF
44 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
45 positive regulation of JUN kinase activity GO:0043507 9.56 EDN1 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 IL1B TNF
47 positive regulation of DNA-binding transcription factor activity GO:0051091 9.55 EDN1 IL10 IL1B IL6 TNF
48 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
49 regulation of signaling receptor activity GO:0010469 9.5 CALCA EDN1 IL10 IL1B IL6 NPY
50 positive regulation of neuroinflammatory response GO:0150078 9.43 IL1B IL6 TNF

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 CALCA EDN1 NPY
2 adrenergic receptor activity GO:0004935 9.26 ADRA1A ADRB2
3 signaling receptor binding GO:0005102 9.26 CALCA EDN1 HLA-B NPY
4 cytokine activity GO:0005125 9.02 EDN1 IL10 IL1B IL6 TNF
Sources

Sources for Complex Regional Pain Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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