Complex Regional Pain Syndrome (CRPS)

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Complex Regional Pain Syndrome

MalaCards integrated aliases for Complex Regional Pain Syndrome:

Name: Complex Regional Pain Syndrome 12 74 52 53 42 15 17
Complex Regional Pain Syndromes 12 54 43 71
Reflex Sympathetic Dystrophy 52 71
Crps 52


External Ids:

Disease Ontology 12 DOID:3223
MeSH 43 D020918
SNOMED-CT 67 128200000
UMLS 71 C0034931 C0458219

Summaries for Complex Regional Pain Syndrome

NINDS : 53 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Complex Regional Pain Syndrome, also known as complex regional pain syndromes, is related to causalgia and reflex sympathetic dystrophy, and has symptoms including seizures, tremor and back pain. An important gene associated with Complex Regional Pain Syndrome is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cytokine Signaling in Immune system. The drugs Triamcinolone and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and bone, and related phenotypes are limb pain and dry skin

NIH Rare Diseases : 52 Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area; skin sensitivity; sweating; and swelling. The underlying cause of CRPS is often not known. Two classifications of CRPS have been recognized based on causalgia. Type I (also known as reflex sympathetic dystrophy), in which there is no evidence of peripheral nerve injury and Type II, in which peripheral nerve injury is present. Treatment aims to relieve pain and often includes different interventions such as topical or oral medications; physical therapy ; and/or a sympathetic nerve block .

MedlinePlus : 42 Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen after an injury, either to a nerve or to tissue in the affected area. Rest and time may only make it worse. Symptoms in the affected area are Dramatic changes in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected joints Decreased ability to move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. Your doctor will diagnose CRPS based on your signs and symptoms. There is no cure. It can get worse over time, and may spread to other parts of the body. Occasionally the symptoms go away, either temporarily or for good. Treatment focuses on relieving the pain, and can include medicines, physical therapy, and nerve blocks. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), describes an... more...

Related Diseases for Complex Regional Pain Syndrome

Diseases related to Complex Regional Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1103)
# Related Disease Score Top Affiliating Genes
1 causalgia 34.1 TACR1 TAC1 CALCA ADRA1A
2 reflex sympathetic dystrophy 34.0 TAC1 NPY CALCA ADRB2 ADRA1A
3 adult-onset still's disease 32.2 TNF IL6 IL1B CXCL8
4 peripheral nervous system disease 31.0 TNF TAC1 SCN9A POMC IL6 IL2
5 hemiplegia 31.0 TAC1 EDN1 CALCA
6 periodontitis, chronic 31.0 IL6 IL1B
7 spinal cord injury 30.9 TNF IL6 CXCL8
8 autonomic nervous system disease 30.9 TACR1 TAC1 SCN9A NPY MIR548D1 IL6
9 herpes zoster 30.8 TNF IL2 IL10
10 bone resorption disease 30.8 TNF IL6 IL1B CALCA
11 arteries, anomalies of 30.8 TNF IL6 IL1B EDN1 CCL2
12 eclampsia 30.7 TNF IL6 EDN1
13 vulvar vestibulitis syndrome 30.7 TNF IL1B
14 tendinitis 30.7 TNF IL6 IL1B
15 temporal arteritis 30.7 TNF IL6 IL1B CCL2
16 haemophilus influenzae 30.7 TNF CXCL8
17 typhoid fever 30.7 TNF IL6 IL1B
18 spondylitis 30.7 TNF IL6 IL10
19 carpal tunnel syndrome 30.6 TAC1 IL6 IL2 IL1B CCL2
20 lipoprotein quantitative trait locus 30.6 TNF IL6 IL1B IL10 EDN1 CXCL8
21 chickenpox 30.6 TNF IL6 IL2 IL10
22 polyneuropathy 30.6 TNF IL6 IL1B CALCA
23 fatty liver disease 30.5 TNF IL6 IL1B CXCL8
24 paine syndrome 30.5 TACR1 TAC1 SCN9A MIR548D1 IL1B CALCA
25 vasculitis 30.5 TNF IL6 IL10 CCL2
26 acute pancreatitis 30.5 TNF IL6 IL1B IL10 CXCL8
27 myofascial pain syndrome 30.5 TAC1 POMC CALCA
28 bacterial infectious disease 30.5 TNF IL6 IL1B IL10 CXCL8 CCL2
29 plague 30.5 TNF IL6 IL1B IL10
30 iridocyclitis 30.5 TNF IL6 IL10
31 prosthetic joint infection 30.5 IL6 IL1B
32 periodontitis 30.5 TNF IL6 IL1B IL10 CXCL8 CCL2
33 mental depression 30.5 TNF POMC IL6 IL1B
34 arteriovenous malformation 30.5 TNF IL6 IL1B EDN1
35 atherosclerosis susceptibility 30.5 TNF IL6 IL1B EDN1 CXCL8 CCL2
36 hyperthyroidism 30.5 TNF POMC IL6 CALCA
37 radiculopathy 30.4 TAC1 IL6 IL10 CXCL8 CCL2
38 leptin deficiency or dysfunction 30.4 TNF POMC NPY IL6
39 carotid stenosis 30.4 TNF IL10 CXCL8
40 peptic ulcer disease 30.4 TNF IL1B IL10 CXCL8
41 salmonellosis 30.4 TNF IL6 IL1B IL10
42 lyme disease 30.4 TNF IL6 IL1B
43 tetanus 30.3 TNF IL6 IL2 IL1B IL10
44 juvenile arthritis 30.3 IL6 IL10 CXCL8
45 non-alcoholic steatohepatitis 30.3 TNF IL6 CXCL8 CCL2
46 acute graft versus host disease 30.3 TNF IL2 IL10
47 arteriosclerosis 30.3 IL6 IL10 EDN1 CCL2
48 acute thyroiditis 30.3 POMC CALCA
49 purpura 30.3 TNF IL6 IL10
50 ulcerative colitis 30.3 TNF IL6 IL2 IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Complex Regional Pain Syndrome:

Diseases related to Complex Regional Pain Syndrome

Symptoms & Phenotypes for Complex Regional Pain Syndrome

Human phenotypes related to Complex Regional Pain Syndrome:

31 (show all 11)
# Description HPO Frequency HPO Source Accession
1 limb pain 31 hallmark (90%) HP:0009763
2 dry skin 31 frequent (33%) HP:0000958
3 erythema 31 frequent (33%) HP:0010783
4 involuntary movements 31 frequent (33%) HP:0004305
5 pedal edema 31 frequent (33%) HP:0010741
6 slow-growing nails 31 frequent (33%) HP:0008383
7 allodynia 31 frequent (33%) HP:0012533
8 edema of the upper limbs 31 frequent (33%) HP:0010742
9 trophic changes related to pain 31 frequent (33%) HP:0010834
10 hyperalgesia 31 frequent (33%) HP:0031005
11 abnormality of hair growth 31 frequent (33%) HP:0040170

UMLS symptoms related to Complex Regional Pain Syndrome:

seizures, tremor, back pain, headache, syncope, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia

MGI Mouse Phenotypes related to Complex Regional Pain Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 ADRA1A ADRB2 IL10 IL2 IL6 MME
2 cardiovascular system MP:0005385 10.1 ADRA1A ADRB2 EDN1 GCH1 IL10 IL1B
3 homeostasis/metabolism MP:0005376 10.1 ADRA1A ADRB2 EDN1 GCH1 IL10 IL1B
4 immune system MP:0005387 9.9 ADRB2 CCL2 IL10 IL1B IL2 IL6
5 integument MP:0010771 9.61 IL10 IL1B IL6 MME POMC SCN9A
6 nervous system MP:0003631 9.44 ADRB2 EDN1 GCH1 IL10 IL1B IL6

Drugs & Therapeutics for Complex Regional Pain Syndrome

Drugs for Complex Regional Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Memantine Approved, Investigational Phase 4 19982-08-2 4054
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
Clozapine Approved Phase 4 5786-21-0 2818
Capsaicin Approved Phase 4 404-86-4 1548943
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
13 Analgesics, Opioid Phase 4
14 Micronutrients Phase 4
15 Trace Elements Phase 4
16 Vitamins Phase 4
17 Antioxidants Phase 4
18 Nutrients Phase 4
19 Protective Agents Phase 4
20 Excitatory Amino Acid Antagonists Phase 4
21 triamcinolone acetonide Phase 4
22 Triamcinolone hexacetonide Phase 4
23 Triamcinolone diacetate Phase 4
24 Anesthetics, Dissociative Phase 4
25 Anesthetics, General Phase 4
26 Anesthetics, Intravenous Phase 4
27 Anti-Infective Agents Phase 4
28 Dopamine Agents Phase 4
29 Antiparkinson Agents Phase 4
30 Anti-Bacterial Agents Phase 4
31 Anticonvulsants Phase 4
32 Anti-Anxiety Agents Phase 4
33 Psychotropic Drugs Phase 4
34 Calcium, Dietary Phase 4
35 calcium channel blockers Phase 4
36 Dermatologic Agents Phase 4
37 Fluorodeoxyglucose F18 Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Zoledronic Acid Approved Phase 3 118072-93-8 68740
Levobupivacaine Approved, Investigational Phase 3 27262-47-1 92253
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
Sodium citrate Approved, Investigational Phase 3 68-04-2
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
Nitrous oxide Approved, Vet_approved Phase 3 10024-97-2 948
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
Cysteine Approved, Nutraceutical Phase 3 52-90-4 5862
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 196)
# Name Status NCT ID Phase Drugs
1 The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
2 Restore Claims Characterization Study Completed NCT00200122 Phase 4
3 Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
4 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 Assessing the Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome - a Feasibility Study Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
6 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
7 Bupivacaine Versus Lidocaine Local Anesthesia in Elective Outpatient Hand Surgery: A Randomized Controlled Trial Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
8 Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome Completed NCT02467556 Phase 4 Morphine, memantine
9 The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty: A Double-Blinded Randomized Controlled Trial Completed NCT00620828 Phase 4 Ropivicaine 0.5%
10 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
11 A Pilot Study of Minocycline Augmentation to Clozapine in Individuals With Treatment Resistant Schizophrenia Completed NCT02124811 Phase 4 Minocycline
12 Does Stellate Ganglion Blockade (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes? A Pilot Prospective Cohort Study Recruiting NCT03796195 Phase 4 .5% Bupivacaine
13 Safety, Efficacy and Patient Acceptability of Topical Treatment Versus Systemic Treatment: a Randomized, Multicentre, Comparative Pragmatic Trial in Adult Patients Suffering From Diverse Localized Neuropathic Pain (LNP) Syndromes Recruiting NCT03348735 Phase 4 Lidocaine patch 5%;Capsaicin 8% Patch;Pregabalin
14 Randomized Clinical Trial of Exparel vs Pain Pump for Post-operative Pain Control After Total Shoulder Arthroplasty Not yet recruiting NCT04364867 Phase 4 Exparel;Pain Pump
15 A Prospective Single Arm Pilot Study to Investigate the Dynamic Brain and Multifidus Muscle Imaging in Response to Multifidus Stimulation in Patients With Low Back Pain Undergoing Reactiv8 Implant Not yet recruiting NCT04327817 Phase 4
16 Effectiveness 0f Sympathetic Plexus Block on Male Pelvic Pain (Prostatitis, Prostatodynia) Suspended NCT00194636 Phase 4
17 CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zoledronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Unknown status NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
18 Prospective, Double-blind, Randomised, Placebo-controlled, Cross-over Study to Investigate the Effect of Intravenous Immunoglobulins on Complex Regional Pain Syndrome (CRPS, M. Sudeck) Unknown status NCT00949065 Phase 3
19 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
20 An Analysis of Photoplethysmographic Signal in Diagnostic Lumbar Sympathetic Block for Complex Regional Pain Syndrome Unknown status NCT01134289 Phase 3
21 Double-Blind Randomized Controlled Trial: Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
22 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
23 Acupuncture and Traditional Chinese Medicine Combined With Rehabilitation Therapy for Post-stroke Shoulder-hand Syndrome in Community Hospital: a Multicenter,Randomized,Controlled Trial Unknown status NCT02011854 Phase 2, Phase 3
24 Effect on Migraine Frequency of Combined Anti-oxidant Therapy: N-acetylcysteine, Vitamin E and Vitamin C (NEC): The MIGRANT Study Unknown status NCT02629536 Phase 3 N-acetyl cysteine 600 mg, VitE 250 IU, VitC 500 mg tablet
25 Novel Non Invasive Brain Stimulation Based Treatment for Chronic Low Back Unknown status NCT02393391 Phase 2, Phase 3
26 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidamide in the Treatment of Complex Regional Pain Syndrome Type1 Completed NCT00166452 Phase 3 Lenalidamide
27 Open-label Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Completed NCT02972359 Phase 3 Neridronic acid
28 A Randomized, Double-blind Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
29 A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
30 Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I Completed NCT00817128 Phase 2, Phase 3
31 A 12-Week Open-Label Study With 3 Within-Patient Double-Blind Placebo-Controlled Periods to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
32 A 12-Month, Open-Label Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) at 15 to 90 mg Every 12 Hours in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
33 The Effectiveness of Taping Technique Versus Conventional Techniques in Prevention of Shoulder Injuries in Patients With Acute Stroke-A Prospective, Randomized, Interventional, Outcome Blinded (PROBE Design), Parallel Design Trial Completed NCT01062308 Phase 3
34 Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain Completed NCT01872481 Phase 3
35 A Prospective Randomized Controlled Pilot Study Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Enrolling by invitation NCT03879538 Phase 3 Nitrous Oxide;Oxygen
36 Placebo-controlled Efficacy and Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03560986 Phase 3 Neridronic acid;Placebo
37 Randomized, Double-blind, Placebo-controlled Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03530345 Phase 3 Neridronic acid;Placebo
38 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
39 Phase 2 Study - The Use of a Single 5 mg Dose of Zoledronic Acid in Complex Regional Pain Syndrome Patient. Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
40 Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
41 Treatment Of Chronic Pain Using Real-time Functional MRI Trial Unknown status NCT00528346 Phase 2
42 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) - a Randomized Trial Unknown status NCT01184586 Phase 2
43 A Multicenter, Open-Label Study to Evaluate the Preliminary Safety and Efficacy of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
44 A Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset Complex Regional Pain Syndrome After Total Knee Arthroplasty Completed NCT00558753 Phase 2 pregabalin;Placebo
45 A Randomized, Cross-over, Placebo-controlled, Double-blind, Single-center, Phase II Study of Cetuximab in Patients With Treatment-refractory, Non-malignant Severe Chronic Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
46 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
47 CCRC: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
48 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
49 A Pilot Trial of Intravenous Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
50 Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis Completed NCT03008590 Phase 2 Naltrexone;Placebo

Search NIH Clinical Center for Complex Regional Pain Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cochrane evidence based reviews: complex regional pain syndromes

Genetic Tests for Complex Regional Pain Syndrome

Anatomical Context for Complex Regional Pain Syndrome

MalaCards organs/tissues related to Complex Regional Pain Syndrome:

Spinal Cord, Skin, Bone, Brain, Testes, Cortex, Dorsal Root Ganglion

Publications for Complex Regional Pain Syndrome

Articles related to Complex Regional Pain Syndrome:

(show top 50) (show all 2963)
# Title Authors PMID Year
Hazard of complex regional pain syndrome following human papillomavirus vaccination among adolescent girls in the United States: a case-cohort analysis of insurance claims data. 61 42
31674255 2020
Clinical phenotypes and classification algorithm for complex regional pain syndrome. 61 42
31874923 2020
Autoantibodies against P29ING4 are associated with complex regional pain syndrome. 42 61
32008173 2019
Behavioral and neurophysiological evidence for altered interoceptive bodily processing in chronic pain. 61
32438047 2020
Altered updating of bodily and spatial representations after tool-use in complex regional pain syndrome. 61
32102024 2020
Spontaneous sensations reveal distorted body perception in complex regional pain syndrome (CRPS). 61
32408059 2020
Complex regional pain syndrome following a centipede bite: a case report. 61
31771369 2020
Optimizing the Treatment of CRPS With Ketamine. 61
32243301 2020
Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex. 61
32096888 2020
Thoracoscopic delivery of therapeutics in the swine sympathetic chain: Implications for future neuromodulation. 61
32336639 2020
Appropriate referral and selection of patients with chronic pain for spinal cord stimulation: European consensus recommendations and e-health tool. 61
32187774 2020
Imatinib-induced bone oedema mimicking Type 1 complex regional pain syndrome. 61
31630208 2020
Expression of Cutaneous Beta-2 Adrenoceptors Is Similar in Patients with Complex Regional Pain Syndrome and Pain-Free Controls. 61
31120123 2020
Neural substrates for poststroke complex regional pain syndrome type I: a retrospective case-control study using voxel-based lesion symptom mapping analysis. 61
31985589 2020
Bodily changes and sensory sensitivity in complex regional pain syndrome and fibromyalgia. 61
32049896 2020
Disputing space-based biases in unilateral complex regional pain syndrome. 61
32251901 2020
Complex regional pain syndrome following laparoscopic gynecological surgery. 61
31204046 2020
Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome. 61
32510695 2020
Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study. 61
32146504 2020
Electroencephalography During Nociceptive Stimulation in Chronic Pain Patients: A Systematic Review. 61
32488229 2020
Epidemiology of painful knee after total knee arthroplasty in a tertiary care center: Assessment by decision tree. 61
32305235 2020
Return to Sport and Patient Satisfaction at 5-Year Follow-up After Nonoperative Treatment for Acute Achilles Tendon Rupture. 61
32543889 2020
Short-Term Teriparatide for Bone Marrow Edema Secondary to Complex Regional Pain Syndrome: Case Reports on Efficacy After Two Years of Follow-Up. 61
32426199 2020
Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses. 61
32446302 2020
Combination of perineural dexamethasone and dexmedetomidine prolong analgesic duration of a supraclavicular block in a patient with complex regional pain syndrome. 61
32473512 2020
Multiple Limb Involvement in a Severe Case of Complex Regional Pain Syndrome Treated With Spinal Cord Stimulation: A Case Report. 61
32520472 2020
Understanding the Rehabilitation Needs of Korean Patients With Complex Regional Pain Syndrome. 61
32475093 2020
[Brain function in complex regional pain syndrome : implications for pain management]. 61
32374530 2020
Fear of movement disturbs inter-limb coupling in complex regional pain syndrome. 61
31465864 2020
Perioperative Outcomes of Spinal Cord Stimulator Placement in Patients with Complex Regional Pain Syndrome Compared with Patients without Complex Regional Pain Syndrome. 61
31954908 2020
A Systematic Review of Economic Evaluations Reporting the Cost-Effectiveness of Spinal Cord Stimulation. 61
32389232 2020
Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. 61
32171889 2020
Germinal center formation, immunoglobulin production and hindlimb nociceptive sensitization after tibia fracture. 61
32413559 2020
Autonomic nervous system may be affected after carpal tunnel syndrome surgery: A possible mechanism for persistence of symptoms after surgery. 61
32579308 2020
MRI of complex regional pain syndrome in the foot. 61
32534352 2020
The use of bisphosphonates to meet orthopaedic challenges. 61
32445893 2020
Nuclear Medicine for the Orthopedic Foot and Ankle Surgeon. 61
32141327 2020
Management of intraarticular proximal interphalangeal joint fracture-dislocations and pilon fractures with the Ligamentotaxor® device. 61
32448930 2020
Description and classification of postpartum chronic pain: A multicentric prospective study. 61
32461069 2020
Efficacy and safety of pulsed radiofrequency as a method of dorsal root ganglia stimulation for treatment of non-neuropathic pain: a systematic review. 61
32366286 2020
The pharmacokinetics, efficacy, and safety of a novel selective-dose cannabis inhaler in patients with chronic pain: A randomized, double-blinded, placebo-controlled trial. 61
32445190 2020
Complex regional pain syndrome: A rare but potentially disabling complication of transradial cardiac catheterization. 61
31148370 2020
A randomized controlled trial on Aspirin and complex regional pain syndrome after radius fractures. 61
32499879 2020
[Exergames for patients with complex regional pain syndrome : A feasibility study]. 61
32095887 2020
Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I. 61
32315759 2020
Bio-Electro-Magnetic-Energy-Regulation (BEMER) for the treatment of type I complex regional pain syndrome: A pilot study. 61
29985719 2020
Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome. 61
32235013 2020
Efficacy of adjuvant dexmedetomidine in supraclavicular brachial plexus block for intractable complex regional pain syndrome: A case report with a 3-year follow-up. 61
31599030 2020
Complex Regional Pain Syndrome. 61
32115056 2020
Effectiveness, Safety, and Predictive Potential in Ultrasound-Guided Stellate Ganglion Blockades for the Treatment of Sympathetically Maintained Pain. 61
32255250 2020

Variations for Complex Regional Pain Syndrome

Expression for Complex Regional Pain Syndrome

Search GEO for disease gene expression data for Complex Regional Pain Syndrome.

Pathways for Complex Regional Pain Syndrome

Pathways related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
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13.34 TNF IL6 IL2 IL1B IL10 CXCL8
Show member pathways
13.11 TNF IL6 IL2 IL1B IL10 CXCL8
Show member pathways
12.9 TNF IL6 IL2 IL1B IL10 CXCL8
Show member pathways
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Show member pathways
12.65 TNF IL6 IL2 IL1B IL10
Show member pathways
12.64 TNF IL6 IL2 IL1B IL10
Show member pathways
12.63 TNF IL6 IL2 IL1B IL10 CCL2
12 12.62 TNF IL2 IL1B IL10 CCL2
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12.39 TNF IL6 IL2 IL1B CCL2
16 12.37 POMC NPY EDN1 ADRB2
Show member pathways
12.35 TNF IL6 IL2 IL10 CXCL8 CCL2
18 12.34 TNF IL6 IL1B CXCL8
19 12.31 TNF IL6 IL1B CXCL8
Show member pathways
12.31 TNF IL6 IL2 IL1B IL10 CXCL8
21 12.3 TNF IL6 IL1B CXCL8 CCL2
22 12.28 TNF IL6 IL1B IL10
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12.27 TNF IL6 IL2 IL1B IL10
Show member pathways
12.23 TNF IL6 IL1B CXCL8
25 12.19 TNF TACR1 TAC1 IL6 IL1B IL10
26 12.14 TNF IL1B EDN1 CCL2
27 12.06 TNF MME IL6 IL2 IL10
28 12.04 TNF IL6 IL1B EDN1 CCL2
Show member pathways
12 TNF IL6 IL2 IL1B IL10
30 11.99 TNF IL6 IL2 IL1B IL10 CXCL8
31 11.97 TNF MME IL6 IL1B
32 11.95 TNF IL6 IL1B IL10 CXCL8
33 11.95 TNF IL6 IL1B EDN1 CXCL8 CCL2
34 11.94 TNF TACR1 IL6 IL2 IL1B CXCL8
35 11.89 TNF IL6 IL1B CXCL8 CCL2
36 11.87 POMC IL6 IL2 CXCL8
37 11.86 TNF POMC IL6 IL1B IL10 CXCL8
38 11.85 TNF IL2 IL1B IL10
Show member pathways
11.79 TNF IL2 CXCL8
40 11.79 TNF IL6 IL1B IL10 CXCL8
41 11.75 TNF POMC NPY
42 11.75 TNF MME IL6 IL2 IL1B IL10
Show member pathways
11.69 TNF IL6 IL2 IL1B CXCL8
44 11.67 TNF IL6 IL1B CXCL8
45 11.6 TNF IL6 IL2
46 11.57 TNF IL1B CCL2
47 11.57 TNF IL2 IL1B
48 11.56 TNF IL6 IL1B CALCA
49 11.45 TNF IL6 IL1B IL10
Show member pathways
11.43 TNF IL2 IL10

GO Terms for Complex Regional Pain Syndrome

Cellular components related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TNF TAC1 POMC NPY IL6 IL2
2 cell GO:0005623 9.65 TOR1A TACR1 TAC1 NPY IL6 IL2
3 extracellular space GO:0005615 9.4 TNF TAC1 POMC NPY IL6 IL2

Biological processes related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 TACR1 POMC IL6 IL1B IL10 CXCL8
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 TNF POMC IL6 IL2 IL1B IL10
3 negative regulation of cell proliferation GO:0008285 10.11 IL6 IL1B IL10 CXCL8 ADRA1A
4 G protein-coupled receptor signaling pathway GO:0007186 10.06 TACR1 TAC1 POMC NPY IL2 EDN1
5 immune response GO:0006955 10.04 TNF IL6 IL2 IL1B IL10 CXCL8
6 aging GO:0007568 9.98 MME IL10 CALCA ADRA1A
7 cellular response to tumor necrosis factor GO:0071356 9.93 EDN1 CXCL8 CCL2 CALCA
8 cellular response to lipopolysaccharide GO:0071222 9.93 TNF IL6 IL1B IL10 CXCL8 CCL2
9 response to lipopolysaccharide GO:0032496 9.92 TAC1 IL1B IL10 GCH1 EDN1
10 positive regulation of cytosolic calcium ion concentration GO:0007204 9.91 TACR1 TAC1 IL2 EDN1 CALCA ADRA1A
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 TNF IL6 IL2
12 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B CCL2
13 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10
14 neuropeptide signaling pathway GO:0007218 9.88 TAC1 POMC NPY CALCA
15 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 TNF IL6 IL1B IL10 EDN1
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 TNF IL1B EDN1
17 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL2 IL1B
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF IL6 EDN1
19 humoral immune response GO:0006959 9.86 TNF IL6 CCL2
20 positive regulation of interleukin-6 production GO:0032755 9.86 TNF IL6 IL1B
21 cytokine-mediated signaling pathway GO:0019221 9.86 TNF POMC IL6 IL2 IL1B IL10
22 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.85 TNF IL10 EDN1
23 neutrophil chemotaxis GO:0030593 9.85 IL1B EDN1 CXCL8 CCL2
24 positive regulation of interferon-gamma production GO:0032729 9.83 TNF IL2 IL1B
25 monocyte chemotaxis GO:0002548 9.83 IL6 CCL2 CALCA
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B EDN1
27 protein kinase B signaling GO:0043491 9.8 TNF IL1B CCL2
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF IL1B CCL2
29 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10
30 positive regulation of interleukin-8 production GO:0032757 9.77 TNF IL1B CALCA
31 sensory perception of pain GO:0019233 9.77 TAC1 SCN9A MME EDN1 CCL2
32 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
33 cell-cell signaling GO:0007267 9.76 TAC1 POMC IL2 IL1B EDN1 CALCA
34 positive regulation of heart rate GO:0010460 9.74 GCH1 EDN1 ADRA1A
35 positive regulation of glial cell proliferation GO:0060252 9.73 TNF IL6 IL1B
36 response to molecule of bacterial origin GO:0002237 9.72 IL10 CXCL8
37 negative regulation of lipid storage GO:0010888 9.72 TNF IL6
38 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 TNF IL1B IL10
40 response to pain GO:0048265 9.71 TACR1 TAC1 GCH1 CALCA
41 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
42 tachykinin receptor signaling pathway GO:0007217 9.7 TACR1 TAC1
43 positive regulation of prostaglandin secretion GO:0032308 9.69 IL1B EDN1
44 positive regulation of neuroinflammatory response GO:0150078 9.69 TNF IL6 IL1B
45 negative regulation of cytokine production involved in immune response GO:0002719 9.68 TNF IL10
46 negative regulation of smooth muscle contraction GO:0045986 9.67 CALCA ADRB2
47 positive regulation of action potential GO:0045760 9.67 TAC1 ADRA1A
48 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 TNF IL10
50 sequestering of triglyceride GO:0030730 9.64 TNF IL1B

Molecular functions related to Complex Regional Pain Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 POMC NPY EDN1 CCL2 CALCA
2 hormone activity GO:0005179 9.26 POMC NPY EDN1 CALCA
3 cytokine activity GO:0005125 9.23 TNF IL6 IL2 IL1B IL10 EDN1

Sources for Complex Regional Pain Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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