MCID: CMP077
MIFTS: 21

Composite Hemangioendothelioma

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Composite Hemangioendothelioma

MalaCards integrated aliases for Composite Hemangioendothelioma:

Name: Composite Hemangioendothelioma 58 71

Characteristics:

Orphanet epidemiological data:

58
composite hemangioendothelioma
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide);

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 D18.0
Orphanet 58 ORPHA458758
UMLS 71 C1304513

Summaries for Composite Hemangioendothelioma

MalaCards based summary : Composite Hemangioendothelioma is related to hemangioendothelioma and angiosarcoma. An important gene associated with Composite Hemangioendothelioma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways is Wnt / Hedgehog / Notch. Affiliated tissues include eye, lymph node and spleen.

Related Diseases for Composite Hemangioendothelioma

Diseases related to Composite Hemangioendothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 10.6
2 angiosarcoma 10.4
3 hemangioma 10.3
4 vascular cancer 10.2
5 spindle cell hemangioma 10.2
6 epithelioid hemangioendothelioma 10.2
7 retiform hemangioendothelioma 10.2
8 rare vascular tumor 10.2
9 arteriovenous malformation 10.1
10 cavernous hemangioma 10.1
11 lymphangioma 10.1
12 conventional angiosarcoma 10.1
13 rare lymphatic malformation 10.1
14 multiple enchondromatosis, maffucci type 9.9
15 hypophosphatemia 9.9
16 paraganglioma 9.9
17 lymphangiosarcoma 9.9
18 alopecia 9.9
19 kaposiform hemangioendothelioma 9.9
20 rare tumor 9.9
21 eccrine acrospiroma 9.6 YAP1 MAML2
22 eccrine sweat gland neoplasm 9.5 YAP1 MAML2

Graphical network of the top 20 diseases related to Composite Hemangioendothelioma:



Diseases related to Composite Hemangioendothelioma

Symptoms & Phenotypes for Composite Hemangioendothelioma

Drugs & Therapeutics for Composite Hemangioendothelioma

Search Clinical Trials , NIH Clinical Center for Composite Hemangioendothelioma

Genetic Tests for Composite Hemangioendothelioma

Anatomical Context for Composite Hemangioendothelioma

MalaCards organs/tissues related to Composite Hemangioendothelioma:

40
Eye, Lymph Node, Spleen, Endothelial

Publications for Composite Hemangioendothelioma

Articles related to Composite Hemangioendothelioma:

(show all 36)
# Title Authors PMID Year
1
Recurrent YAP1 and MAML2 Gene Rearrangements in Retiform and Composite Hemangioendothelioma. 61
32991341 2020
2
Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a "Paraganglioma-Like" Paravertebral Case. 61
32418470 2020
3
Composite hemangioendothelioma: the first case of a right atrioventricular pericardial tumour. 61
32617478 2020
4
[Composite hemangioendothelioma with neuroendocrine marker expression: report of a case]. 61
32486550 2020
5
Composite Hemangioendothelioma Settled in the Paraspinal Region: A Rare Case Report. 61
29757449 2020
6
Intramuscular composite hemangioendothelioma: case report of an unusual tumor in an unusual location. 61
32661479 2020
7
What is new in endothelial neoplasia? 61
31463731 2020
8
Epithelioid Vascular Tumors: A Review. 61
30762622 2019
9
Composite hemangioendothelioma of the forehead and right eye; a case report. 61
29233122 2017
10
[Composite hemangioendothelioma of the parotid gland: a case report]. 61
29262459 2017
11
Composite hemangioendothelioma with neuroendocrine marker expression: an aggressive variant. 61
28731049 2017
12
Composite hemangioendothelioma with neuroendocrine marker expression: an aggressive variant. 61
28972580 2017
13
Reconstruction With β-Tricalcium Phosphate After Navicular Tumor Resection. 61
27839663 2017
14
Composite Hemangioendothelioma: Report of a Rare Case. 61
27891348 2016
15
Composite Hemangioendothelioma of the Submandibular Region. 61
25666464 2015
16
Composite hemangioendothelioma: clinical and histologic features of an enigmatic entity. 61
26050262 2015
17
Composite hemangioendothelioma: An unusual presentation of a rare vascular tumor. 61
24713748 2014
18
Cutaneous composite hemangioendothelioma: case report and review of published reports. 61
24894791 2014
19
Bone scan, MRI, and FDG PET/CT findings in composite hemangioendothelioma of the manubrium sterni. 61
24018832 2014
20
Cutaneous composite hemangioendothelioma on the nose treated with electron beam. 61
22998114 2013
21
Composite hemangioendothelioma presenting as a scalp nodule with alopecia. 61
23866898 2013
22
Composite hemangioendothelioma and its classification as a low-grade malignancy. 61
23694827 2013
23
Hemangioendothelioma. 61
23327728 2013
24
Composite hemangioendothelioma arising from the kidney: case report with review of the literature. 61
24040461 2013
25
Composite hemangioendothelioma on the neck. 61
23089324 2012
26
A case of composite hemangioendothelioma arising from the spleen. 61
22844130 2012
27
[Retiform haemangioendothelioma: a case report]. 61
20005438 2009
28
Mediastinal composite hemangioendothelioma. A rare tumor at an unusual location. 61
19366065 2009
29
Composite hemangioendothelioma of the oral cavity: case report and review of the literature. 61
18286494 2008
30
Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases. 61
18190450 2008
31
Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. 61
17895759 2007
32
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. 61
16778491 2006
33
[Reversion of hypophosphatemia after the excision of a composite hemangioendothelioma in the great toe]. 61
14558246 2003
34
Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum. 61
12028155 2002
35
Composite hemangioendothelioma: a complex, low-grade vascular lesion mimicking angiosarcoma. 61
10716148 2000
36
Recent developments in soft tissue tumors. 61
10095415 1998

Variations for Composite Hemangioendothelioma

Expression for Composite Hemangioendothelioma

Search GEO for disease gene expression data for Composite Hemangioendothelioma.

Pathways for Composite Hemangioendothelioma

Pathways related to Composite Hemangioendothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 YAP1 MAML2

GO Terms for Composite Hemangioendothelioma

Biological processes related to Composite Hemangioendothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.16 YAP1 MAML2
2 transcription initiation from RNA polymerase II promoter GO:0006367 8.96 YAP1 MAML2
3 positive regulation of Notch signaling pathway GO:0045747 8.62 YAP1 MAML2

Molecular functions related to Composite Hemangioendothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coactivator activity GO:0003713 8.62 YAP1 MAML2

Sources for Composite Hemangioendothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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