MCID: CMP001
MIFTS: 36

Composite Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Composite Lymphoma

MalaCards integrated aliases for Composite Lymphoma:

Name: Composite Lymphoma 12 58 44 15 17 70
Composite Hodgkin and Non-Hodgkin Lymphoma 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:5820
MeSH 44 D058617
NCIt 50 C38661
MESH via Orphanet 45 D058617
UMLS via Orphanet 71 C0545080 C1266191
Orphanet 58 ORPHA168966
UMLS 70 C0545080

Summaries for Composite Lymphoma

Disease Ontology : 12 A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time.

MalaCards based summary : Composite Lymphoma, also known as composite hodgkin and non-hodgkin lymphoma, is related to follicular lymphoma and lymphoma, hodgkin, classic. An important gene associated with Composite Lymphoma is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are Transcriptional misregulation in cancer and NF-kappaB Signaling. The drugs Vincristine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and bone marrow, and related phenotypes are hematopoietic system and immune system

Related Diseases for Composite Lymphoma

Diseases related to Composite Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 follicular lymphoma 30.6 MME CD5 BCL6
2 lymphoma, hodgkin, classic 30.4 TNFRSF8 TIA1 PAX5 GZMB BCL6
3 mycosis fungoides 30.3 TNFRSF8 TIA1 GZMB
4 lymphoma 30.1 TNFRSF8 TIA1 PAX5 GZMB CD5 CD274
5 hodgkin's lymphoma, lymphocytic-histiocytic predominance 30.1 TNFRSF8 FUT4 BCL6
6 richter's syndrome 30.1 IGHV4-38-2 CD5
7 cutaneous t cell lymphoma 30.1 TNFRSF8 TIA1 GZMB
8 lymphoproliferative syndrome 30.1 TNFRSF8 TIA1 CD5 BCL6
9 primary mediastinal large b-cell lymphoma 30.1 CD274 BCL6
10 t-cell lymphoma, subcutaneous panniculitis-like 30.0 TNFRSF8 TIA1 GZMB
11 panniculitis 30.0 TNFRSF8 TIA1 GZMB
12 primary central nervous system lymphoma 29.9 PAX5 BCL6
13 anaplastic large cell lymphoma 29.8 TNFRSF8 TIA1 PAX5 GZMB
14 mantle cell lymphoma 29.8 PAX5 MME CD5 CD274 BCL6
15 lymphosarcoma 29.7 TNFRSF8 CD22 BCL6
16 central nervous system lymphoma 29.7 PAX5 CD274 BCL6
17 peripheral t-cell lymphoma 29.7 TNFRSF8 TIA1 MME GZMB CD5 CD274
18 angioimmunoblastic t-cell lymphoma 29.6 TNFRSF8 TIA1 MME GZMB CD274 BCL6
19 b-cell lymphoma 29.5 TNFRSF8 TIA1 PAX5 MME CD5 CD274
20 diffuse large b-cell lymphoma 29.5 TNFRSF8 PAX5 MME CD79A CD5 CD274
21 nodal marginal zone lymphoma 29.5 MME IGHV4-38-2 CD5 BCL6
22 burkitt lymphoma 29.4 TNFRSF8 PAX5 MME BCL6
23 celiac disease 1 29.4 TIA1 GZMB CD79A
24 reticulosarcoma 29.3 TNFRSF8 TIA1 PAX5 GZMB BCL6
25 lymphoblastic lymphoma 29.1 TNFRSF8 PAX5 MME CD5 BCL6
26 lung lymphoma 28.9 TNFRSF8 PAX5 MME CD79A CD5 BCL6
27 mature t-cell and nk-cell lymphoma 28.8 TNFRSF8 TIA1 MME GZMB CD79A CD5
28 cll/sll 28.7 PAX5 MME IGHV4-38-2 CD79A CD5 CD22
29 leukemia, chronic lymphocytic 28.5 TNFRSF8 PAX5 MME IGHV4-38-2 CD79A CD5
30 marginal zone b-cell lymphoma 28.5 TNFRSF8 PAX5 MME IGHV4-38-2 CD79A CD5
31 lymphoma, non-hodgkin, familial 28.5 TNFRSF8 PAX5 MME IGHV4-38-2 GZMB CD79A
32 lymphoplasmacytic lymphoma 28.2 PAX5 MME IGHV4-38-2 CD79A CD5 CD22
33 mature b-cell neoplasm 28.0 TNFRSF8 PAX5 MME IGHV4-38-2 CD79A CD5
34 leukemia, acute myeloid 27.3 TNFRSF8 PAX5 MME IGHV4-38-2 FUT4 CD79A
35 lymphomatoid granulomatosis 10.3 TIA1 GZMB
36 systemic epstein-barr virus-positive t-cell lymphoma of childhood 10.3 TIA1 GZMB
37 primary cutaneous anaplastic large cell lymphoma 10.3 TIA1 GZMB
38 lichen sclerosus et atrophicus 10.3 TIA1 GZMB
39 hepatosplenic t-cell lymphoma 10.3 TIA1 GZMB
40 lymphocytic gastritis 10.3 TIA1 GZMB
41 parapsoriasis 10.3 TNFRSF8 CD5
42 retroperitoneal lymphoma 10.3 TNFRSF8 MME
43 follicular mucinosis 10.2 TNFRSF8 CD5
44 submandibular adenitis 10.2 TNFRSF8 PAX5
45 orbital cellulitis 10.2 TNFRSF8 MME
46 acute orbital inflammation 10.2 TNFRSF8 MME
47 heart lymphoma 10.2 MME BCL6
48 lethal midline granuloma 10.2 TNFRSF8 TIA1 GZMB
49 ovarian lymphoma 10.2 MME BCL6
50 lymphomatoid papulosis 10.2 TNFRSF8 TIA1 GZMB

Graphical network of the top 20 diseases related to Composite Lymphoma:



Diseases related to Composite Lymphoma

Symptoms & Phenotypes for Composite Lymphoma

MGI Mouse Phenotypes related to Composite Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 BCL6 CD22 CD274 CD5 CD79A FUT4
2 immune system MP:0005387 9.36 BCL6 CD22 CD274 CD5 CD79A FUT4

Drugs & Therapeutics for Composite Lymphoma

Drugs for Composite Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
2
Prednisone Approved, Vet_approved Phase 1 53-03-2 5865
3
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
4
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
5
Pembrolizumab Approved Phase 1 1374853-91-4
6
rituximab Approved Phase 1 174722-31-7 10201696
7
Cortisone Experimental Phase 1 53-06-5 222786
8 Tubulin Modulators Phase 1
9 Antibiotics, Antitubercular Phase 1
10 Immunosuppressive Agents Phase 1
11
Liposomal doxorubicin Phase 1 31703
12 Immunoglobulins, Intravenous Phase 1
13 Antineoplastic Agents, Immunological Phase 1
14 Antimitotic Agents Phase 1
15 Antibodies Phase 1
16 Hormone Antagonists Phase 1
17 Immunologic Factors Phase 1
18 glucocorticoids Phase 1
19 Immunoglobulins Phase 1
20 Hormones Phase 1
21 Antirheumatic Agents Phase 1
22 Alkylating Agents Phase 1
23 Antineoplastic Agents, Hormonal Phase 1
24 Antibodies, Monoclonal Phase 1
25 Anti-Bacterial Agents Phase 1
26 Anti-Inflammatory Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MK-3475 in Combination With Standard RCHOP Therapy for Previously Untreated Diffuse Large B-Cell Lymphoma Completed NCT02541565 Phase 1 Cyclophosphamide;Doxorubicin Hydrochloride;Prednisone;Vincristine Sulfate

Search NIH Clinical Center for Composite Lymphoma

Cochrane evidence based reviews: composite lymphoma

Genetic Tests for Composite Lymphoma

Anatomical Context for Composite Lymphoma

MalaCards organs/tissues related to Composite Lymphoma:

40
Lymph Node, Spleen, Bone Marrow, Salivary Gland, Small Intestine, Skin, Testis

Publications for Composite Lymphoma

Articles related to Composite Lymphoma:

(show top 50) (show all 217)
# Title Authors PMID Year
1
Clonal dynamics in a composite chronic lymphocytic leukemia and hairy cell leukemia-variant. 61
33277788 2021
2
Pathological and molecular analysis of a composite lymphoma of mantle cell lymphoma and Epstein-Barr virus-positive follicular lymphoma. 61
33387297 2021
3
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome. 61
33739791 2021
4
Primary Cutaneous B-Cell Lymphoma Complicated by Clonal T-Cell Populations: A Diagnostic Dilemma. 61
33481377 2021
5
Composite Lymphoma Containing Mantle Cell and Peripheral T-cell Lymphoma, Not Otherwise Specified: A Report of 2 Cases Treated With Up-front Autologous Stem Cell Transplantation. 61
30973352 2020
6
Composite follicular lymphoma and "early" (in situ and mantle zone growth pattern) mantle cell neoplasia: A rare entity with peculiar cytogenetic and clinical features. 61
32825940 2020
7
Cutaneous composite lymphoma of mycosis fungoides and Hodgkin lymphoma: Response to sequential therapy. 61
32285466 2020
8
Composite lymphoma of cervical lymph nodes with classical Hodgkin lymphoma and diffuse large B cell lymphoma: a case report and literature review. 61
32921109 2020
9
Transformation of a low-grade follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma and a lymphoblastic neoplasm expressing Terminal deoxynucleotidyl Transferase: a case report. 61
32713346 2020
10
Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Mantle Cell Lymphoma; Small Cell Variant: A Real Diagnostic Challenge. Case Presentation and Review of Literature. 61
32150530 2020
11
Chronic lymphocytic leukemia with progressive anemia secondary to development of composite lymphoma. 61
32128199 2020
12
Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases. 61
31894883 2020
13
Coexistence of Hodgkin and Non-Hodgkin Lymphoma; Composite Lymphoma [CL] in a Patient Presenting with Waxing and Waning Lymphadenopathy. 61
31633478 2020
14
Composite Epstein-Barr virus-positive mucosa-associated lymphoid tissue lymphoma and Epstein-Barr virus-negative diffuse large B-cell lymphoma in the parotid salivary gland of a patient with Sjögren's syndrome and rheumatoid arthritis: a case report. 61
31948469 2020
15
Chronic Lymphocytic Leukemia with Divergent Richter's Transformation into a Clonally Related Classical Hodgkin's and Plasmablastic Lymphoma: A Case Report. 61
32231533 2020
16
Orbital soft tissue composite lymphoma presenting as recurrence of a nodal lymphoma with mantle and follicular cell components: A case report, literature review and guideline for the treatment of patients. 61
31932010 2020
17
Clinicopathological analysis of composite lymphoma: A two-case report and literature review. 61
33336022 2020
18
Case Report: Composite Angioimmunoblastic T-Cell Lymphoma and Epstein-Barr Virus-Positive B-Cell Lymphoproliferative Disorder as Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders. 61
33425968 2020
19
Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer. 61
32224560 2020
20
Clonally Related Plasmablastic Lymphoma Simultaneously Occurring with Diffuse Large B-Cell Lymphoma. 61
33335784 2020
21
Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog. 61
31733649 2019
22
The Conundrum of Diagnosing Cutaneous Composite Lymphoma in the Molecular Age. 61
30973519 2019
23
Acute liver injury leading to death in the setting of brentuximab vedotin monotherapy. 61
30822188 2019
24
Composite lymphoma comprising mantle cell lymphoma and Epstein-Barr virus positive classic Hodgkin lymphoma: A rare case. 61
31361250 2019
25
Peripheral lymphadenopathy: role of excisional biopsy in differential diagnosis based on a five-year experience. 61
30306770 2019
26
Common origin of sequential cutaneous CD30+ lymphoproliferations with nodal involvement evidenced by genome-wide clonal evolution. 61
30393995 2019
27
High-grade B-cell lymphomas with TdT expression: a diagnostic and classification dilemma. 61
30181564 2019
28
[Enteropathy-associated T-cell lymphoma coexisting with composite lymphoma composed of DLBCL and PTCL]. 61
31068515 2019
29
A Case of Composite Lymphoma with Extranodal NK/T-cell Lymphoma, Nasal-type and Diffuse Large B-cell Lymphoma. 61
30918142 2019
30
Cutaneous composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma: a unique entity and a putative pathological mechanism for cutaneous composite lymphomas. 61
30650954 2019
31
A composite lymphoma combining a Hodgkin lymphoma and a marginal zone lymphoma transformed into a diffuse large B-cell lymphoma. 61
30564326 2018
32
Clinicopathological features of splenic tumours of lymphoid tissue. 61
30087035 2018
33
Spectrum of lymphoma in Bahrain. A retrospective analysis according to the World Health Organization classification. 61
29968899 2018
34
Three coexisting lymphomas in a single patient: composite lymphoma derived from a common germinal center B-cell precursor and unrelated discordant lymphoma. 61
29177642 2018
35
Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study. 61
29217426 2018
36
High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma. 61
29793519 2018
37
Composite cutaneous lymphoma of diffuse large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell lymphoma. 61
29851123 2018
38
Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma. 61
29415977 2018
39
Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. 61
28109040 2018
40
A Rare Case of Composite Dural Extranodal Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. 61
29740389 2018
41
Burkitt lymphoma and diffuse large B-cell lymphoma: a unique case of a composite lymphoma of different clonal origin. 61
28583033 2018
42
Detecting a rare composite small bowel lymphoma by Magnetic Resonance Imaging coincidentally: A case report with radiological, surgical and histopathological features. 61
29684805 2018
43
Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma. 61
30155322 2018
44
Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma. 61
30515337 2018
45
Composite angioimmunoblastic T cell/diffuse large B-cell lymphoma treated with reduced-intensity conditioning HLA-haploidentical allo-HSCT: a case report and review of the literature. 61
31949632 2018
46
[The microenvironment and immune status of peripheral T-cell lymphoma: focusing on AITL and ATLL]. 61
29877249 2018
47
[Tumors of lymphoid and hematopoietic tissue of spleen: a clinicopathologic analysis of 53 cases]. 61
29136691 2017
48
Composite Blastoid Variant of Mantle Cell Lymphoma and Classical Hodgkin Lymphoma. 61
27829209 2017
49
Four Lymphomas in 1 Patient: A Unique Case of Triple Composite Non-Hodgkin Lymphoma Followed by Classical Hodgkin Lymphoma. 61
27688525 2017
50
Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis. 61
28191697 2017

Variations for Composite Lymphoma

Expression for Composite Lymphoma

Search GEO for disease gene expression data for Composite Lymphoma.

Pathways for Composite Lymphoma

Pathways related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.78 PAX5 GZMB BCL6
2 11.61 TNFRSF8 PAX5 GZMB CD79A CD274 BCL6
3 11.43 MME CD5 CD22
4 11.32 MME CD79A CD5 CD22
5 11.15 PAX5 CD274 BCL6

GO Terms for Composite Lymphoma

Cellular components related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 IGHV4-38-2 CD79A CD5 CD274 CD22

Biological processes related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell activation GO:0042113 8.62 CD79A CD22

Sources for Composite Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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