MCID: CMP001
MIFTS: 34

Composite Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Composite Lymphoma

MalaCards integrated aliases for Composite Lymphoma:

Name: Composite Lymphoma 12 60 45 15 17 74
Composite Hodgkin and Non-Hodgkin Lymphoma 60

Classifications:



External Ids:

Disease Ontology 12 DOID:5820
MeSH 45 D058617
NCIt 51 C38661
MESH via Orphanet 46 D058617
UMLS via Orphanet 75 C0545080 C1266191
Orphanet 60 ORPHA168966
UMLS 74 C0545080

Summaries for Composite Lymphoma

Disease Ontology : 12 A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time.

MalaCards based summary : Composite Lymphoma, also known as composite hodgkin and non-hodgkin lymphoma, is related to natural killer cell leukemia and cll/sll. An important gene associated with Composite Lymphoma is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Vincristine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung.

Related Diseases for Composite Lymphoma

Diseases related to Composite Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 natural killer cell leukemia 30.0 GZMB TIA1
2 cll/sll 29.9 CD5 PAX5
3 anaplastic large cell lymphoma 29.6 GZMB PAX5
4 lymphoma, hodgkin, classic 29.6 BCL6 CD5 PAX5
5 b-cell lymphomas 29.6 BCL6 CD5 PAX5 TIA1
6 mycosis fungoides 29.6 GZMB TIA1
7 marginal zone b-cell lymphoma 29.5 BCL6 CD5
8 peripheral t-cell lymphoma 29.4 BCL6 CD5 GZMB TIA1
9 cutaneous t cell lymphoma 29.4 GZMB TIA1
10 lymphoma, non-hodgkin, familial 29.4 BCL6 CD5 GZMB PAX5
11 mantle cell lymphoma 29.3 BCL6 CD5 PAX5
12 leukemia, chronic lymphocytic 29.3 BCL6 CD5 PAX5
13 angioimmunoblastic t-cell lymphoma 29.1 BCL6 GZMB TIA1
14 lymphoma 10.6
15 orbit lymphoma 10.3 GZMB TIA1
16 lichen sclerosus et atrophicus 10.3 GZMB TIA1
17 lymphomatoid granulomatosis 10.3 GZMB TIA1
18 viral esophagitis 10.3 GZMB TIA1
19 lymphocytic gastritis 10.3 GZMB TIA1
20 subcutaneous panniculitis-like t-cell lymphoma 10.3 GZMB TIA1
21 panniculitis 10.3 GZMB TIA1
22 primary cutaneous anaplastic large cell lymphoma 10.3 GZMB TIA1
23 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
24 lymphomatoid papulosis 10.2 GZMB TIA1
25 choriocarcinoma of the testis 10.2 GZMB TIA1
26 t-cell adult acute lymphocytic leukemia 10.2 CD5 TIA1
27 giardiasis 10.2 GZMB TIA1
28 infiltrating lipoma 10.2 GZMB TIA1
29 diffuse large b-cell lymphoma 10.1
30 bladder lymphoma 10.1 CD5 PAX5
31 leukemia 10.1
32 necrotizing sialometaplasia 10.1 CD5 GZMB TIA1
33 ileum cancer 10.0 CD5 GZMB TIA1
34 b-cell expansion with nfkb and t-cell anergy 10.0 CD5 GZMB TIA1
35 leukemia, chronic lymphocytic 2 10.0
36 lymphocytic leukemia 10.0
37 leukemia, b-cell, chronic 10.0
38 breast lymphoma 10.0 BCL6 CD5
39 follicular lymphoma 10.0
40 intravascular large b-cell lymphoma 10.0 BCL6 CD5
41 colon lymphoma 9.9 BCL6 CD5
42 epidural neoplasm 9.9 BCL6 CD5
43 nodular lymphocyte predominant hodgkin lymphoma 9.9 BCL6 PAX5
44 intraocular lymphoma 9.9 BCL6 PAX5
45 primary central nervous system lymphoma 9.9 BCL6 PAX5
46 lymphosarcoma 9.8 BCL6 CD5
47 multicentric castleman disease 9.8 BCL6 PAX5
48 castleman disease 9.8 BCL6 PAX5
49 autoimmune lymphoproliferative syndrome, type v 9.8 BCL6 CD5 TIA1
50 lymphatic system cancer 9.8 BCL6 CD5 TIA1

Graphical network of the top 20 diseases related to Composite Lymphoma:



Diseases related to Composite Lymphoma

Symptoms & Phenotypes for Composite Lymphoma

Drugs & Therapeutics for Composite Lymphoma

Drugs for Composite Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
2
Prednisone Approved, Vet_approved Phase 1 53-03-2 5865
3
Pembrolizumab Approved Phase 1 1374853-91-4
4
Cyclophosphamide Approved, Investigational Phase 1 6055-19-2, 50-18-0 2907
5
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
6
rituximab Approved Phase 1 174722-31-7 10201696
7
Doxil Approved June 1999 Phase 1 31703
8
Cortisone Experimental Phase 1 53-06-5 222786
9
Emodepside Investigational, Vet_approved Phase 1 155030-63-0
10 Immunoglobulins Phase 1
11 Anti-Bacterial Agents Phase 1
12 Anti-Inflammatory Agents Phase 1
13 Antineoplastic Agents, Alkylating Phase 1
14 Antibodies, Monoclonal Phase 1
15 Antineoplastic Agents, Immunological Phase 1
16 Hormones Phase 1
17 Immunosuppressive Agents Phase 1
18 Antibodies Phase 1
19 Antineoplastic Agents, Hormonal Phase 1
20 Hormone Antagonists Phase 1
21 Immunologic Factors Phase 1
22 Topoisomerase Inhibitors Phase 1
23 Alkylating Agents Phase 1
24 Antibiotics, Antitubercular Phase 1
25 Antimitotic Agents Phase 1
26 Antineoplastic Agents, Phytogenic Phase 1
27 Antirheumatic Agents Phase 1
28 glucocorticoids Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Diffuse Large B-cell Lymphoma or Grade 3b Follicular Lymphoma Recruiting NCT02541565 Phase 1 Cyclophosphamide;Doxorubicin Hydrochloride;Prednisone;Vincristine Sulfate
2 Italian Multicenter Retrospective Observational Study on Transformed Lymphomas Recruiting NCT02927756

Search NIH Clinical Center for Composite Lymphoma

Cochrane evidence based reviews: composite lymphoma

Genetic Tests for Composite Lymphoma

Anatomical Context for Composite Lymphoma

MalaCards organs/tissues related to Composite Lymphoma:

42
B Cells, T Cells, Lung, Spleen, Small Intestine, Lymph Node

Publications for Composite Lymphoma

Articles related to Composite Lymphoma:

(show top 50) (show all 75)
# Title Authors Year
1
Cutaneous composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma: a unique entity and a putative pathological mechanism for cutaneous composite lymphomas. ( 30650954 )
2019
2
Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma. ( 29415977 )
2018
3
Burkitt lymphoma and diffuse large B-cell lymphoma: a unique case of a composite lymphoma of different clonal origin. ( 28583033 )
2018
4
High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma. ( 29793519 )
2018
5
Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma. ( 30515337 )
2018
6
A composite lymphoma combining a Hodgkin lymphoma and a marginal zone lymphoma transformed into a diffuse large B-cell lymphoma. ( 30564326 )
2018
7
Composite Lymphoma: Opposite Ends of Spectrum Meet. ( 28179969 )
2017
8
Three coexisting lymphomas in a single patient: composite lymphoma derived from a common germinal center B-cell precursor and unrelated discordant lymphoma. ( 29177642 )
2017
9
Composite Lymphoma of Follicular B-cell and Peripheral T-cell Types with Distinct Zone Distribution in a 75-year-old Male Patient: a Case Study. ( 29217426 )
2017
10
Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis. ( 28191697 )
2017
11
Composite lymphoma with coexistence of diffuse large B-cell lymphoma and anaplastic large cell lymphoma: Diagnostic pitfalls. ( 28631654 )
2017
12
A rare composite lymphoma: follicular and in situ mantle cell. ( 27103006 )
2016
13
A Patient with Supraclavicular Lymphadenopathy and Anterior Mediastinal Mass Presenting as a Rare Case of Composite Lymphoma: A Case Report and Literature Review. ( 28203178 )
2016
14
Pegylated liposomal-encapsulated doxorubicin in cutaneous composite lymphoma: A case report. ( 27787356 )
2016
15
Composite lymphoma with diffuse large B-cell lymphoma and classical Hodgkin lymphoma components: A case report and review of the literature. ( 27887763 )
2016
16
Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. ( 25596254 )
2015
17
Diffuse Large B-cell Lymphoma of Germinal Center and Nongerminal Center Phenotypes Presenting Concurrently at the Same Anatomic Site: Intratumoral Heterogeneity or Composite Lymphoma? ( 25153495 )
2014
18
Primary composite lymphoma of the lung: a case report. ( 25506376 )
2014
19
Independent growth of diffuse large B cell lymphoma and angioimmunoblastic T cell lymphoma originating from composite lymphoma. ( 24488225 )
2014
20
Composite lymphoma in a patient with ulcerative colitis: a case report. ( 25774267 )
2014
21
Therapy-related acute myeloblastic leukemia after splenectomy in a patient with composite lymphoma developing after treatment of chronic lymphocytic leukemia. ( 24101115 )
2013
22
Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. ( 23313307 )
2013
23
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. ( 24427365 )
2013
24
Diffuse large B-cell lymphoma arising in a composite lymphoma with biclonality by flow cytometry and one monoclonal band by PCR. ( 24427364 )
2013
25
Composite lymphoma after chemotherapy with regressed diffuse large B-cell lymphoma and transformed cytotoxic T-cell lymphoma. ( 23009219 )
2013
26
Composite lymphoma of nodular lymphocyte-predominant and classical Hodgkin lymphoma-Epstein-Barr virus association suggests divergent pathogenesis despite clonal relatedness. ( 23427872 )
2013
27
Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. ( 23005596 )
2012
28
Primary composite lymphoma of the larynx, composed of diffuse large B-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, presenting as left subglottic tracheal fistula, esophageal diverticulum, and neck abscess. ( 22371913 )
2012
29
Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications. ( 22221705 )
2012
30
Epstein-Barr virus-associated lymphoproliferative disorder presenting with classical Hodgkin lymphoma and developing as peripheral T-cell lymphoma 9 years later: a case report of composite lymphoma. ( 22126384 )
2011
31
Composite lymphoma in the anterior mediastinum: a case report and review of the literature. ( 21733146 )
2011
32
Usefulness of multiparametric flow cytometry in detecting composite lymphoma: study of 17 cases in a 12-year period. ( 21411776 )
2011
33
The composite lymphoma: chronic lymphocytic leukemia--classic Hodgkin's lymphoma. ( 20495755 )
2010
34
Large-cell transformation of a composite lymphoma. ( 20621095 )
2010
35
Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. ( 20871392 )
2010
36
Composite lymphoma with relapse of enteropathy-type T-cell lymphoma. ( 19330653 )
2009
37
Composite lymphoma: EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma: a case report. ( 19115485 )
2009
38
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: a case report of composite lymphoma. ( 19269751 )
2009
39
Composite lymphoma of the orbit treated with rituximab. ( 17413631 )
2007
40
Review article composite lymphoma. ( 19190689 )
2007
41
Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma. ( 17613783 )
2007
42
Methotrexate-associated lymphoproliferative disorder mimicking composite lymphoma. ( 16757440 )
2006
43
Sequential application of chemotherapy and monoclonal CD 20 antibody: successful treatment of advanced composite-lymphoma. ( 15621815 )
2005
44
Composite lymphoma: angiocentric T-cell lymphoma (CD8+ cytotoxic/suppressor T-cell) and diffuse large B-cell lymphoma associated with EBV, and presenting clinically as a midfacial necrotizing lesion. ( 14747069 )
2004
45
An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease. ( 15291370 )
2004
46
Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein. ( 15168595 )
2004
47
Composite lymphoma arising in the parotid gland: a case report. ( 15041061 )
2004
48
A common clonal origin of nodal marginal zone B-cell lymphoma and plasma cell myeloma demonstrating different immunophenotypes: a case report of composite lymphoma. ( 15167008 )
2004
49
Cutaneous T cell lymphoma and classic Hodgkin lymphoma of the B cell type within a single lymph node: composite lymphoma. ( 14990612 )
2004
50
Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma. ( 12149227 )
2002

Variations for Composite Lymphoma

Expression for Composite Lymphoma

Search GEO for disease gene expression data for Composite Lymphoma.

Pathways for Composite Lymphoma

Pathways related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.85 BCL6 GZMB PAX5
2 11.4 BCL6 GZMB PAX5
3 10.52 BCL6 CD5 PAX5

GO Terms for Composite Lymphoma

Sources for Composite Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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