MCID: CMP001
MIFTS: 34

Composite Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Composite Lymphoma

MalaCards integrated aliases for Composite Lymphoma:

Name: Composite Lymphoma 12 60 45 15 17 74
Composite Hodgkin and Non-Hodgkin Lymphoma 60

Classifications:



External Ids:

Disease Ontology 12 DOID:5820
MeSH 45 D058617
NCIt 51 C38661
MESH via Orphanet 46 D058617
UMLS via Orphanet 75 C0545080 C1266191
Orphanet 60 ORPHA168966
UMLS 74 C0545080

Summaries for Composite Lymphoma

Disease Ontology : 12 A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time.

MalaCards based summary : Composite Lymphoma, also known as composite hodgkin and non-hodgkin lymphoma, is related to natural killer cell leukemia and cll/sll. An important gene associated with Composite Lymphoma is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Prednisone and rituximab have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung.

Related Diseases for Composite Lymphoma

Diseases related to Composite Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 natural killer cell leukemia 30.0 GZMB TIA1
2 cll/sll 29.9 CD5 PAX5
3 anaplastic large cell lymphoma 29.7 GZMB PAX5
4 lymphoma, hodgkin, classic 29.6 BCL6 CD5 PAX5
5 mycosis fungoides 29.6 GZMB TIA1
6 marginal zone b-cell lymphoma 29.5 BCL6 CD5
7 peripheral t-cell lymphoma 29.5 BCL6 CD5 GZMB TIA1
8 cutaneous t cell lymphoma 29.4 GZMB TIA1
9 lymphoma, non-hodgkin, familial 29.4 BCL6 CD5 GZMB PAX5
10 mantle cell lymphoma 29.3 BCL6 CD5 PAX5
11 leukemia, chronic lymphocytic 29.3 BCL6 CD5 PAX5
12 angioimmunoblastic t-cell lymphoma 29.2 BCL6 GZMB TIA1
13 b-cell lymphomas 28.7 BCL6 CD5 PAX5 TIA1
14 lymphoma 10.6
15 orbit lymphoma 10.3 GZMB TIA1
16 lichen sclerosus et atrophicus 10.3 GZMB TIA1
17 lymphomatoid granulomatosis 10.3 GZMB TIA1
18 viral esophagitis 10.3 GZMB TIA1
19 lymphocytic gastritis 10.3 GZMB TIA1
20 panniculitis 10.3 GZMB TIA1
21 primary cutaneous anaplastic large cell lymphoma 10.3 GZMB TIA1
22 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
23 lymphomatoid papulosis 10.2 GZMB TIA1
24 choriocarcinoma of the testis 10.2 GZMB TIA1
25 t-cell adult acute lymphocytic leukemia 10.2 CD5 TIA1
26 giardiasis 10.2 GZMB TIA1
27 diffuse large b-cell lymphoma 10.2
28 infiltrating lipoma 10.2 GZMB TIA1
29 bladder lymphoma 10.1 CD5 PAX5
30 leukemia 10.1
31 necrotizing sialometaplasia 10.1 CD5 GZMB TIA1
32 ileum cancer 10.1 CD5 GZMB TIA1
33 b-cell expansion with nfkb and t-cell anergy 10.0 CD5 GZMB TIA1
34 leukemia, chronic lymphocytic 2 10.0
35 lymphocytic leukemia 10.0
36 leukemia, b-cell, chronic 10.0
37 follicular lymphoma 10.0
38 breast lymphoma 10.0 BCL6 CD5
39 intravascular large b-cell lymphoma 10.0 BCL6 CD5
40 colon lymphoma 9.9 BCL6 CD5
41 epidural neoplasm 9.9 BCL6 CD5
42 nodular lymphocyte predominant hodgkin lymphoma 9.9 BCL6 PAX5
43 intraocular lymphoma 9.9 BCL6 PAX5
44 primary central nervous system lymphoma 9.9 BCL6 PAX5
45 lymphosarcoma 9.8 BCL6 CD5
46 multicentric castleman disease 9.8 BCL6 PAX5
47 castleman disease 9.8 BCL6 PAX5
48 autoimmune lymphoproliferative syndrome, type v 9.8 BCL6 CD5 TIA1
49 lymphatic system cancer 9.8 BCL6 CD5 TIA1
50 mediastinal malignant lymphoma 9.8 BCL6 PAX5

Graphical network of the top 20 diseases related to Composite Lymphoma:



Diseases related to Composite Lymphoma

Symptoms & Phenotypes for Composite Lymphoma

Drugs & Therapeutics for Composite Lymphoma

Drugs for Composite Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 1 53-03-2 5865
2
rituximab Approved Phase 1 174722-31-7 10201696
3
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
4
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
5
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
6
Pembrolizumab Approved Phase 1 1374853-91-4
7
Cortisone Experimental Phase 1 53-06-5 222786
8
Doxil Approved June 1999 Phase 1 31703
9
Emodepside Investigational, Vet_approved Phase 1 155030-63-0
10 Hormones Phase 1
11 Antineoplastic Agents, Hormonal Phase 1
12 Immunoglobulins Phase 1
13 Anti-Bacterial Agents Phase 1
14 Antineoplastic Agents, Phytogenic Phase 1
15 Antimitotic Agents Phase 1
16 Antibodies, Monoclonal Phase 1
17 Topoisomerase Inhibitors Phase 1
18 glucocorticoids Phase 1
19 Hormone Antagonists Phase 1
20 Antibodies Phase 1
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
22 Alkylating Agents Phase 1
23 Immunosuppressive Agents Phase 1
24 Antineoplastic Agents, Immunological Phase 1
25 Antibiotics, Antitubercular Phase 1
26 Antirheumatic Agents Phase 1
27 Anti-Inflammatory Agents Phase 1
28 Immunologic Factors Phase 1
29 Antineoplastic Agents, Alkylating Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Diffuse Large B-cell Lymphoma or Grade 3b Follicular Lymphoma Recruiting NCT02541565 Phase 1 Cyclophosphamide;Doxorubicin Hydrochloride;Prednisone;Vincristine Sulfate
2 Italian Multicenter Retrospective Observational Study on Transformed Lymphomas Recruiting NCT02927756

Search NIH Clinical Center for Composite Lymphoma

Cochrane evidence based reviews: composite lymphoma

Genetic Tests for Composite Lymphoma

Anatomical Context for Composite Lymphoma

MalaCards organs/tissues related to Composite Lymphoma:

42
B Cells, T Cells, Lung, Spleen, Small Intestine, Lymph Node, Colon

Publications for Composite Lymphoma

Articles related to Composite Lymphoma:

(show top 50) (show all 79)
# Title Authors Year
1
Cutaneous composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma: a unique entity and a putative pathological mechanism for cutaneous composite lymphomas. ( 30650954 )
2019
2
A Case of Composite Lymphoma with Extranodal NK/T-cell Lymphoma, Nasal-type and Diffuse Large B-cell Lymphoma. ( 30918142 )
2019
3
Composite Lymphoma Containing Mantle Cell and Peripheral T-cell Lymphoma, Not Otherwise Specified: A Report of 2 Cases Treated With Up-front Autologous Stem Cell Transplantation. ( 30973352 )
2019
4
The Conundrum of Diagnosing Cutaneous Composite Lymphoma in the Molecular Age. ( 30973519 )
2019
5
Burkitt lymphoma and diffuse large B-cell lymphoma: a unique case of a composite lymphoma of different clonal origin. ( 28583033 )
2018
6
Three coexisting lymphomas in a single patient: composite lymphoma derived from a common germinal center B-cell precursor and unrelated discordant lymphoma. ( 29177642 )
2018
7
Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study. ( 29217426 )
2018
8
Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma. ( 29415977 )
2018
9
High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma. ( 29793519 )
2018
10
Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma. ( 30515337 )
2018
11
A composite lymphoma combining a Hodgkin lymphoma and a marginal zone lymphoma transformed into a diffuse large B-cell lymphoma. ( 30564326 )
2018
12
Composite lymphoma with coexistence of diffuse large B-cell lymphoma and anaplastic large cell lymphoma: Diagnostic pitfalls. ( 28631654 )
2017
13
Composite Lymphoma: Opposite Ends of Spectrum Meet. ( 28179969 )
2017
14
Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis. ( 28191697 )
2017
15
A rare composite lymphoma: follicular and in situ mantle cell. ( 27103006 )
2016
16
Pegylated liposomal-encapsulated doxorubicin in cutaneous composite lymphoma: A case report. ( 27787356 )
2016
17
Composite lymphoma with diffuse large B-cell lymphoma and classical Hodgkin lymphoma components: A case report and review of the literature. ( 27887763 )
2016
18
A Patient with Supraclavicular Lymphadenopathy and Anterior Mediastinal Mass Presenting as a Rare Case of Composite Lymphoma: A Case Report and Literature Review. ( 28203178 )
2016
19
Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? ( 25153495 )
2015
20
Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. ( 25596254 )
2015
21
Independent growth of diffuse large B cell lymphoma and angioimmunoblastic T cell lymphoma originating from composite lymphoma. ( 24488225 )
2014
22
Therapy-related acute myeloblastic leukemia after splenectomy in a patient with composite lymphoma developing after treatment of chronic lymphocytic leukemia. ( 24101115 )
2014
23
Diffuse large B-cell lymphoma arising in a composite lymphoma with biclonality by flow cytometry and one monoclonal band by PCR. ( 24427364 )
2014
24
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. ( 24427365 )
2014
25
Primary composite lymphoma of the lung: a case report. ( 25506376 )
2014
26
Composite lymphoma in a patient with ulcerative colitis: a case report. ( 25774267 )
2014
27
Composite lymphoma after chemotherapy with regressed diffuse large B-cell lymphoma and transformed cytotoxic T-cell lymphoma. ( 23009219 )
2013
28
Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. ( 23313307 )
2013
29
Composite lymphoma of nodular lymphocyte-predominant and classical Hodgkin lymphoma-Epstein-Barr virus association suggests divergent pathogenesis despite clonal relatedness. ( 23427872 )
2013
30
Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. ( 23005596 )
2012
31
Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications. ( 22221705 )
2012
32
Primary composite lymphoma of the larynx, composed of diffuse large B-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, presenting as left subglottic tracheal fistula, esophageal diverticulum, and neck abscess. ( 22371913 )
2012
33
Usefulness of multiparametric flow cytometry in detecting composite lymphoma: study of 17 cases in a 12-year period. ( 21411776 )
2011
34
Composite lymphoma in the anterior mediastinum: a case report and review of the literature. ( 21733146 )
2011
35
Epstein-Barr virus-associated lymphoproliferative disorder presenting with classical Hodgkin lymphoma and developing as peripheral T-cell lymphoma 9 years later: a case report of composite lymphoma. ( 22126384 )
2011
36
The composite lymphoma: chronic lymphocytic leukemia--classic Hodgkin's lymphoma. ( 20495755 )
2010
37
Large-cell transformation of a composite lymphoma. ( 20621095 )
2010
38
Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. ( 20871392 )
2010
39
Composite lymphoma: EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma: a case report. ( 19115485 )
2009
40
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: a case report of composite lymphoma. ( 19269751 )
2009
41
Composite lymphoma with relapse of enteropathy-type T-cell lymphoma. ( 19330653 )
2009
42
Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma. ( 17613783 )
2007
43
Composite lymphoma of the orbit treated with rituximab. ( 17413631 )
2007
44
Review article composite lymphoma. ( 19190689 )
2007
45
Methotrexate-associated lymphoproliferative disorder mimicking composite lymphoma. ( 16757440 )
2006
46
Sequential application of chemotherapy and monoclonal CD 20 antibody: successful treatment of advanced composite-lymphoma. ( 15621815 )
2005
47
Cutaneous T cell lymphoma and classic Hodgkin lymphoma of the B cell type within a single lymph node: composite lymphoma. ( 14990612 )
2004
48
Composite lymphoma arising in the parotid gland: a case report. ( 15041061 )
2004
49
A common clonal origin of nodal marginal zone B-cell lymphoma and plasma cell myeloma demonstrating different immunophenotypes: a case report of composite lymphoma. ( 15167008 )
2004
50
Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein. ( 15168595 )
2004

Variations for Composite Lymphoma

Expression for Composite Lymphoma

Search GEO for disease gene expression data for Composite Lymphoma.

Pathways for Composite Lymphoma

Pathways related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.85 BCL6 GZMB PAX5
2 11.4 BCL6 GZMB PAX5
3 10.52 BCL6 CD5 PAX5

GO Terms for Composite Lymphoma

Sources for Composite Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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