MCID: CMP001
MIFTS: 36

Composite Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Composite Lymphoma

MalaCards integrated aliases for Composite Lymphoma:

Name: Composite Lymphoma 12 59 44 15 73
Composite Hodgkin and Non-Hodgkin Lymphoma 59

Classifications:



External Ids:

Disease Ontology 12 DOID:5820
MeSH 44 D058617
NCIt 50 C38661
Orphanet 59 ORPHA168966
MESH via Orphanet 45 D058617
UMLS via Orphanet 74 C0545080 C1266191
UMLS 73 C0545080

Summaries for Composite Lymphoma

Disease Ontology : 12 A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time.

MalaCards based summary : Composite Lymphoma, also known as composite hodgkin and non-hodgkin lymphoma, is related to natural killer cell leukemia and b-cell lymphomas. An important gene associated with Composite Lymphoma is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Cyclophosphamide and rituximab have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and lung.

Related Diseases for Composite Lymphoma

Diseases related to Composite Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 natural killer cell leukemia 29.9 GZMB TIA1
2 b-cell lymphomas 29.8 BCL6 CD5 PAX5 TIA1
3 peripheral t-cell lymphoma 29.8 BCL6 CD5 GZMB TIA1
4 lymphoma, hodgkin, classic 29.7 BCL6 CD5 PAX5
5 marginal zone b-cell lymphoma 29.6 BCL6 CD5
6 anaplastic large cell lymphoma 29.4 GZMB PAX5
7 angioimmunoblastic t-cell lymphoma 29.3 BCL6 GZMB TIA1
8 leukemia, chronic lymphocytic 29.3 BCL6 CD5 PAX5
9 cutaneous t cell lymphoma 29.3 GZMB TIA1
10 mantle cell lymphoma 29.1 BCL6 CD5 PAX5 SOX11
11 cll/sll 29.1 CD5 PAX5 SOX11
12 burkitt lymphoma 28.9 BCL6 PAX5 SOX11
13 lymphoma 10.5
14 orbit lymphoma 10.2 GZMB TIA1
15 lichen sclerosus et atrophicus 10.2 GZMB TIA1
16 lymphomatoid granulomatosis 10.2 GZMB TIA1
17 viral esophagitis 10.2 GZMB TIA1
18 lymphocytic gastritis 10.2 GZMB TIA1
19 subcutaneous panniculitis-like t-cell lymphoma 10.2 GZMB TIA1
20 panniculitis 10.2 GZMB TIA1
21 primary cutaneous anaplastic large cell lymphoma 10.2 GZMB TIA1
22 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
23 lymphomatoid papulosis 10.2 GZMB TIA1
24 choriocarcinoma of the testis 10.1 GZMB TIA1
25 t-cell adult acute lymphocytic leukemia 10.1 CD5 TIA1
26 giardiasis 10.1 GZMB TIA1
27 diffuse large b-cell lymphoma 10.1
28 infiltrating lipoma 10.1 GZMB TIA1
29 breast lymphoma 10.1 BCL6 CD5
30 intravascular large b-cell lymphoma 10.1 BCL6 CD5
31 necrotizing sialometaplasia 10.0 CD5 GZMB TIA1
32 ileum cancer 10.0 CD5 GZMB TIA1
33 b-cell expansion with nfkb and t-cell anergy 10.0 CD5 GZMB TIA1
34 colon lymphoma 10.0 BCL6 CD5
35 epidural neoplasm 10.0 BCL6 CD5
36 bladder lymphoma 10.0 CD5 PAX5
37 lymphosarcoma 10.0 BCL6 CD5
38 leukemia 10.0
39 autoimmune lymphoproliferative syndrome, type v 9.9 BCL6 CD5 TIA1
40 lymphatic system cancer 9.9 BCL6 CD5 TIA1
41 leukemia, chronic lymphocytic 2 9.9
42 lymphocytic leukemia 9.9
43 leukemia, b-cell, chronic 9.9
44 lymphoblastic lymphoma 9.9 BCL6 CD5
45 nodular lymphocyte predominant hodgkin lymphoma 9.9 BCL6 PAX5
46 intraocular lymphoma 9.9 BCL6 PAX5
47 lymphoma, mucosa-associated lymphoid type 9.9 BCL6 CD5
48 primary central nervous system lymphoma 9.9 BCL6 PAX5
49 multicentric castleman disease 9.9 BCL6 PAX5
50 castleman disease 9.8 BCL6 PAX5

Graphical network of the top 20 diseases related to Composite Lymphoma:



Diseases related to Composite Lymphoma

Symptoms & Phenotypes for Composite Lymphoma

Drugs & Therapeutics for Composite Lymphoma

Drugs for Composite Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 1 6055-19-2, 50-18-0 2907
2
rituximab Approved Phase 1 174722-31-7 10201696
3
Vincristine Approved, Investigational Phase 1 57-22-7, 2068-78-2 5978
4
Prednisone Approved, Vet_approved Phase 1 53-03-2 5865
5
Cortisone acetate Approved, Investigational Phase 1 1950-04-4, 50-04-4 5745
6
Pembrolizumab Approved Phase 1 1374853-91-4
7
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
8
Doxil Approved June 1999 Phase 1 31703
9
Cortisone Experimental Phase 1 53-06-5 222786
10 Hormone Antagonists Phase 1
11 Hormones Phase 1
12 Antineoplastic Agents, Hormonal Phase 1
13 Topoisomerase Inhibitors Phase 1
14 Antineoplastic Agents, Alkylating Phase 1
15 Antibodies, Monoclonal Phase 1
16 Antirheumatic Agents Phase 1
17 Antibiotics, Antitubercular Phase 1
18 Antibodies Phase 1
19 Immunoglobulins Phase 1
20 Alkylating Agents Phase 1
21 Antimitotic Agents Phase 1
22 Anti-Inflammatory Agents Phase 1
23 Anti-Bacterial Agents Phase 1
24 Antineoplastic Agents, Phytogenic Phase 1
25 Immunosuppressive Agents Phase 1
26 Immunologic Factors Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
28 glucocorticoids Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pembrolizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Diffuse Large B-cell Lymphoma or Grade 3b Follicular Lymphoma Recruiting NCT02541565 Phase 1 Cyclophosphamide;Doxorubicin Hydrochloride;Prednisone;Vincristine Sulfate
2 Italian Multicenter Retrospective Observational Study on Transformed Lymphomas Recruiting NCT02927756

Search NIH Clinical Center for Composite Lymphoma

Cochrane evidence based reviews: composite lymphoma

Genetic Tests for Composite Lymphoma

Anatomical Context for Composite Lymphoma

MalaCards organs/tissues related to Composite Lymphoma:

41
B Cells, T Cells, Lung, Spleen, Colon, Breast, Testis

Publications for Composite Lymphoma

Articles related to Composite Lymphoma:

(show top 50) (show all 73)
# Title Authors Year
1
Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma. ( 29415977 )
2018
2
Burkitt lymphoma and diffuse large B-cell lymphoma: a unique case of a composite lymphoma of different clonal origin. ( 28583033 )
2018
3
High-grade B-cell lymphoma with MYC and BCL2 rearrangements arising in a composite lymphoma. ( 29793519 )
2018
4
Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma. ( 30515337 )
2018
5
Composite Lymphoma: Opposite Ends of Spectrum Meet. ( 28179969 )
2017
6
Three coexisting lymphomas in a single patient: composite lymphoma derived from a common germinal center B-cell precursor and unrelated discordant lymphoma. ( 29177642 )
2017
7
Composite Lymphoma of Follicular B-cell and Peripheral T-cell Types with Distinct Zone Distribution in a 75-year-old Male Patient: a Case Study. ( 29217426 )
2017
8
Composite lymphoma of peripheral T-cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis. ( 28191697 )
2017
9
Composite lymphoma with coexistence of diffuse large B-cell lymphoma and anaplastic large cell lymphoma: Diagnostic pitfalls. ( 28631654 )
2017
10
A rare composite lymphoma: follicular and in situ mantle cell. ( 27103006 )
2016
11
A Patient with Supraclavicular Lymphadenopathy and Anterior Mediastinal Mass Presenting as a Rare Case of Composite Lymphoma: A Case Report and Literature Review. ( 28203178 )
2016
12
Pegylated liposomal-encapsulated doxorubicin in cutaneous composite lymphoma: A case report. ( 27787356 )
2016
13
Composite lymphoma with diffuse large B-cell lymphoma and classical Hodgkin lymphoma components: A case report and review of the literature. ( 27887763 )
2016
14
Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. ( 25596254 )
2015
15
Diffuse Large B-cell Lymphoma of Germinal Center and Nongerminal Center Phenotypes Presenting Concurrently at the Same Anatomic Site: Intratumoral Heterogeneity or Composite Lymphoma? ( 25153495 )
2014
16
Primary composite lymphoma of the lung: a case report. ( 25506376 )
2014
17
Independent growth of diffuse large B cell lymphoma and angioimmunoblastic T cell lymphoma originating from composite lymphoma. ( 24488225 )
2014
18
Composite lymphoma in a patient with ulcerative colitis: a case report. ( 25774267 )
2014
19
Therapy-related acute myeloblastic leukemia after splenectomy in a patient with composite lymphoma developing after treatment of chronic lymphocytic leukemia. ( 24101115 )
2013
20
Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. ( 23313307 )
2013
21
A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. ( 24427365 )
2013
22
Diffuse large B-cell lymphoma arising in a composite lymphoma with biclonality by flow cytometry and one monoclonal band by PCR. ( 24427364 )
2013
23
Composite lymphoma after chemotherapy with regressed diffuse large B-cell lymphoma and transformed cytotoxic T-cell lymphoma. ( 23009219 )
2013
24
Composite lymphoma of nodular lymphocyte-predominant and classical Hodgkin lymphoma-Epstein-Barr virus association suggests divergent pathogenesis despite clonal relatedness. ( 23427872 )
2013
25
Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas. ( 23005596 )
2012
26
Primary composite lymphoma of the larynx, composed of diffuse large B-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, presenting as left subglottic tracheal fistula, esophageal diverticulum, and neck abscess. ( 22371913 )
2012
27
Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications. ( 22221705 )
2012
28
Epstein-Barr virus-associated lymphoproliferative disorder presenting with classical Hodgkin lymphoma and developing as peripheral T-cell lymphoma 9 years later: a case report of composite lymphoma. ( 22126384 )
2011
29
Composite lymphoma in the anterior mediastinum: a case report and review of the literature. ( 21733146 )
2011
30
Usefulness of multiparametric flow cytometry in detecting composite lymphoma: study of 17 cases in a 12-year period. ( 21411776 )
2011
31
The composite lymphoma: chronic lymphocytic leukemia--classic Hodgkin's lymphoma. ( 20495755 )
2010
32
Large-cell transformation of a composite lymphoma. ( 20621095 )
2010
33
Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. ( 20871392 )
2010
34
Composite lymphoma with relapse of enteropathy-type T-cell lymphoma. ( 19330653 )
2009
35
Composite lymphoma: EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma: a case report. ( 19115485 )
2009
36
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: a case report of composite lymphoma. ( 19269751 )
2009
37
Composite lymphoma of the orbit treated with rituximab. ( 17413631 )
2007
38
Review article composite lymphoma. ( 19190689 )
2007
39
Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma. ( 17613783 )
2007
40
Methotrexate-associated lymphoproliferative disorder mimicking composite lymphoma. ( 16757440 )
2006
41
Sequential application of chemotherapy and monoclonal CD 20 antibody: successful treatment of advanced composite-lymphoma. ( 15621815 )
2005
42
Composite lymphoma: angiocentric T-cell lymphoma (CD8+ cytotoxic/suppressor T-cell) and diffuse large B-cell lymphoma associated with EBV, and presenting clinically as a midfacial necrotizing lesion. ( 14747069 )
2004
43
An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease. ( 15291370 )
2004
44
Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein. ( 15168595 )
2004
45
Composite lymphoma arising in the parotid gland: a case report. ( 15041061 )
2004
46
A common clonal origin of nodal marginal zone B-cell lymphoma and plasma cell myeloma demonstrating different immunophenotypes: a case report of composite lymphoma. ( 15167008 )
2004
47
Cutaneous T cell lymphoma and classic Hodgkin lymphoma of the B cell type within a single lymph node: composite lymphoma. ( 14990612 )
2004
48
Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma. ( 12149227 )
2002
49
Composite lymphoma of Hodgkin lymphoma and mycosis fungoides: previously undescribed in the same extracutaneous site. ( 11699423 )
2001
50
An unusual variant of composite lymphoma: a short case report and review of the literature. ( 10975943 )
2000

Variations for Composite Lymphoma

Expression for Composite Lymphoma

Search GEO for disease gene expression data for Composite Lymphoma.

Pathways for Composite Lymphoma

Pathways related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.85 BCL6 GZMB PAX5
2 11.4 BCL6 GZMB PAX5
3 10.52 BCL6 CD5 PAX5

GO Terms for Composite Lymphoma

Biological processes related to Composite Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron differentiation GO:0045666 8.96 BCL6 SOX11
2 skeletal muscle cell differentiation GO:0035914 8.62 PAX5 SOX11

Sources for Composite Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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