MCID: CNG069
MIFTS: 46

Congenital Cytomegalovirus

Categories: Rare diseases

Aliases & Classifications for Congenital Cytomegalovirus

MalaCards integrated aliases for Congenital Cytomegalovirus:

Name: Congenital Cytomegalovirus 53
Congenital Cytomegalovirus Infection 73

Classifications:



External Ids:

UMLS 73 C0158945

Summaries for Congenital Cytomegalovirus

NIH Rare Diseases : 53 Congenital cytomegalovirus (congenital CMV) is a group of symptoms that may occur when an infant is infected with the cytomegalovirus before birth. Most infants who are infected with the virus never develop symptoms of the condition. However, approximately 10% of babies will experience health problems and/or disabilities such as problems with the lungs, liver and/or spleen at birth; hearing loss; vision loss; intellectual disability; seizures; small head size; and/or lack of coordination. Some babies with the condition may have evidence of infection at birth, while others may not develop symptoms for two or more years. Congenital CMV occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta. Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Congenital Cytomegalovirus, also known as congenital cytomegalovirus infection, is related to cytomegalovirus infection and toxoplasmosis. An important gene associated with Congenital Cytomegalovirus is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways are Influenza A and NF-kappaB Signaling. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, placenta and lung, and related phenotypes are immune system and integument

Related Diseases for Congenital Cytomegalovirus

Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 cytomegalovirus infection 31.6 CCL2 IL1B TNF
2 toxoplasmosis 29.5 IL1B TLR2 TNF
3 pneumonia 29.3 CCL2 IL1B TLR2 TNF
4 meningitis 29.0 CCL2 IL1B TLR2 TNF
5 lung disease 29.0 CCL2 IL1B TLR2 TNF
6 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
7 sensorineural hearing loss 10.3
8 deafness, autosomal dominant 24 10.2 GJB2 GJB6
9 purulent labyrinthitis 10.2 CCL2 IL1B
10 retinitis pigmentosa 73 10.2 CCL2 IL1B
11 kid syndrome 10.2 GJB2 GJB6
12 pseudoainhum 10.2 GJB2 GJB6
13 knuckle pads 10.2 GJB2 GJB6
14 knuckle pads, leukonychia, and sensorineural deafness 10.2 GJB2 GJB6
15 deafness, x-linked 2 10.2 GJB2 GJB6
16 dfnb1 10.2 GJB2 GJB6
17 vohwinkel syndrome 10.2 GJB2 GJB6
18 erdheim-chester disease 10.2 CCL2 IL1B
19 deafness, autosomal recessive 1a 10.2 GJB2 GJB6
20 deafness, autosomal recessive 23 10.2 GJB2 GJB6
21 deafness, autosomal recessive 7 10.2 GJB2 MT-RNR1
22 deafness, autosomal dominant 36 10.2 GJB2 MT-RNR1
23 fetal cytomegalovirus syndrome 10.2
24 vestibular disease 10.2 GJB2 GJB6
25 erythrokeratodermia variabilis et progressiva 1 10.1 GJB2 GJB6
26 idiopathic bilateral vestibulopathy 10.1 MT-RNR1 RNR1
27 exudative glomerulonephritis 10.1 IL1B TNF
28 scleritis 10.1 CCL2 TNF
29 deafness, autosomal recessive 30 10.1 GJB2 MT-RNR1
30 anthracosis 10.1 CCL2 TNF
31 staphylococcal toxic shock syndrome 10.1 IL1B TNF
32 deafness, autosomal dominant 2a 10.1 GJB2 GJB6
33 kashin-beck disease 10.1 IL1B TNF
34 rheumatoid lung disease 10.1 IL1B TNF
35 vulvar vestibulitis syndrome 10.1 IL1B TNF
36 deafness, autosomal recessive 16 10.1 GJB2 GJB6
37 burns 10.1 IL1B TNF
38 glossitis 10.1 IL1B TNF
39 laryngitis 10.1 IL1B TNF
40 hodgkin's lymphoma, nodular sclerosis 10.1 GJB2 GJB6 MT-RNR1
41 opisthorchiasis 10.1 IL1B TNF
42 retinitis pigmentosa 60 10.1 IL1B TNF
43 irritant dermatitis 10.1 IL1B TNF
44 auditory system disease 10.1 GJB2 GJB6 MT-RNR1
45 acute vascular insufficiency of intestine 10.1 IL1B TNF
46 actinic prurigo 10.1 IL1B TNF
47 osteosclerotic myeloma 10.1 IL1B TNF
48 crohn's colitis 10.1 IL1B TNF
49 poems syndrome 10.1 IL1B TNF
50 ischemic heart disease 10.1 CCL2 TNF

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to Congenital Cytomegalovirus

Symptoms & Phenotypes for Congenital Cytomegalovirus

MGI Mouse Phenotypes related to Congenital Cytomegalovirus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 CCL2 GJB2 GJB6 IL1B PPARG RNASET2
2 integument MP:0010771 9.1 GJB2 GJB6 IL1B PPARG TLR2 TNF

Drugs & Therapeutics for Congenital Cytomegalovirus

Drugs for Congenital Cytomegalovirus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4,Phase 2,Phase 3 59277-89-3 2022
2 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
4 valacyclovir Phase 4,Phase 2,Phase 3
5
Valganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 175865-60-8 64147
6
Ganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 82410-32-0 3454
7
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
8
Povidone Approved Phase 3 9003-39-8
9 Pharmaceutical Solutions Phase 3,Phase 2
10 Ganciclovir triphosphate Phase 3,Phase 2,Phase 1
11 Antibodies Phase 3,Phase 1,Phase 2,Not Applicable
12 Immunoglobulins, Intravenous Phase 3,Not Applicable
13 gamma-Globulins Phase 3,Not Applicable
14 Rho(D) Immune Globulin Phase 3,Not Applicable
15 Immunoglobulins Phase 3,Phase 1,Phase 2,Not Applicable
16 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
17 Sodium Benzoate Phase 3
18 Immunoglobulin G Phase 3
19 Immunologic Factors Phase 1, Phase 2,Phase 2,Not Applicable
20 Antibodies, Monoclonal Phase 1, Phase 2
21 MF59 oil emulsion Phase 2
22 Vaccines Phase 2,Phase 1,Not Applicable
23 Krestin

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir Terminated NCT01037712 Phase 4 Valacyclovir (ZELITREX);Placebo
2 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment Unknown status NCT02005822 Phase 3 Valganciclovir
3 A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections. Completed NCT00001100 Phase 3 ganciclovir
4 Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection Completed NCT00004278 Phase 3 ganciclovir
5 Short-Term vs. Long-Term Valganciclovir Therapy for Symptomatic Congenital CMV Infections Completed NCT00466817 Phase 3 Valganciclovir
6 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Recruiting NCT02606266 Phase 2, Phase 3 Valganciclovir
7 Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Recruiting NCT02351102 Phase 2, Phase 3 Valacyclovir;Placebo
8 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
9 Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants Enrolling by invitation NCT03107871 Phase 3 Valganciclovir;Simple Syrup
10 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
11 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3 Valganciclovir
12 Valganciclovir in Congenital CMV Infants Completed NCT00031434 Phase 1, Phase 2 Valganciclovir;Ganciclovir
13 Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease Completed NCT00004642 Phase 1, Phase 2 SDZ MSL-109
14 Recombinant CMV gB Vaccine in Postpartum Women Completed NCT00125502 Phase 2 MF59 adjuvant;Placebo
15 Valganciclovir Therapy in Infants and Children With Congenital CMV Infection and Hearing Loss Recruiting NCT01649869 Phase 2 Valganciclovir
16 Asymptomatic Congenital CMV Treatment Not yet recruiting NCT03301415 Phase 2 Valganciclovir
17 Safety, Tolerability, and Immunogenicity of a Cytomegalovirus DNA Vaccine Withdrawn NCT02594566 Phase 1 CyMVectin
18 Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women With Primary Cytomegalovirus Infection Unknown status NCT01659684 Not Applicable
19 Genotyping of Cytomegalovirus From Patients in Israel Unknown status NCT00228202
20 Screening for Congenital Cytomegalovirus Infection in Newborns Completed NCT02683096
21 A Cross-sectional Study of Congenital Cytomegalovirus Infection in Newborns in China Completed NCT02710864
22 The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment Completed NCT01162330
23 Clinical Trial of Behavioral Modification to Prevent Congenital Cytomegalovirus Completed NCT01819519 Not Applicable
24 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Completed NCT02680743 Not Applicable
25 Neonatal CMV-Ganciclovir Follow-up Study Completed NCT00031421
26 Study of the Transmission of Cytomegalovirus (CMV) Infection From Mother to Foetus Completed NCT01251744 Not Applicable
27 Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection? Completed NCT00872703
28 Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital CMV Recruiting NCT02782988
29 Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa Recruiting NCT03722615
30 Reducing Acquisition of CMV Through Antenatal Education Recruiting NCT03511274 Not Applicable
31 Biomarkers of Cytomegalovirus Fetal Infection and Disease Recruiting NCT03090841
32 Immunological Characteristics of Maternal-fetal Transmission of Cytomegalovirus in Pregnancy Recruiting NCT02129465
33 Relevance of Gastric Aspirate in HCMV Detection Recruiting NCT03262194
34 Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening Active, not recruiting NCT02139423 Not Applicable
35 Prognostic Value of Neonatal Markers for the Development of Neurosensorial Sequelae in Children Infected by Cytomegalovirus in Utero Active, not recruiting NCT01923636 Not Applicable
36 A Cohort Study of Cytomegalovirus(CMV) Infection Among Pregnant Women and Their Newborns in China Active, not recruiting NCT02645396
37 Development of Potential Biomarkers for Foetal Brain Development After Congenital CMV Infection Not yet recruiting NCT03188679 Not Applicable
38 Cytomegalovirus (CMV) Vaccines: Reinfection and Antigenic Variation Not yet recruiting NCT03443791 Not Applicable

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

MalaCards organs/tissues related to Congenital Cytomegalovirus:

41
Testes, Placenta, Lung, Liver, Spleen, Brain, T Cells

Publications for Congenital Cytomegalovirus

Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 872)
# Title Authors Year
1
Congenital cytomegalovirus, parvovirus and enterovirus infection in Mozambican newborns at birth: A cross-sectional survey. ( 29538464 )
2018
2
Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection. ( 29784513 )
2018
3
Risk Factors, Geographic Distribution, and Healthcare Burden of Symptomatic Congenital Cytomegalovirus Infection in the United States: Analysis of a Nationally Representative Database, 2000-2012. ( 29706491 )
2018
4
Hearing Trajectory in Children with Congenital Cytomegalovirus Infection. ( 29557247 )
2018
5
Unusual complication of fulminant congenital cytomegalovirus infection. ( 29843259 )
2018
6
Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection. ( 29359492 )
2018
7
Hematologic Adverse Events Associated with Prolonged Valganciclovir Treatment in Congenital Cytomegalovirus Infection. ( 29677086 )
2018
8
Neonates with congenital Cytomegalovirus and hearing loss identified via the universal newborn hearing screening program. ( 29571077 )
2018
9
Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections. ( 29343580 )
2018
10
Viral Loads in Congenital Cytomegalovirus Infection From a Highly Immune Population. ( 29860410 )
2018
11
Does screening for congenital cytomegalovirus at birth improve longer term hearing outcomes? ( 29705727 )
2018
12
Cochlear implant performance in children deafened by congenital cytomegalovirus-A systematic review. ( 29768731 )
2018
13
A rational approach to identifying newborns with hearing loss caused by congenital cytomegalovirus infection by dried blood spot screening. ( 29513124 )
2018
14
Congenital Cytomegalovirus Infection Presenting with Isolated Secretory Diarrhoea Mimicking a Congenital Diarrhoeal Disorder. ( 29611315 )
2018
15
Congenital cytomegalovirus pneumonitis and treatment response evaluation using viral load during ganciclovir therapy: a case report. ( 29709989 )
2018
16
Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Infants Who Fail Newborn Hearing Screening. ( 29373759 )
2018
17
Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection. ( 29441223 )
2018
18
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
19
Closer to Universal Newborn Screening for Congenital Cytomegalovirus Infection but Far Away from Antiviral Therapy in All Infected Infants. ( 29703574 )
2018
20
Congenital Cytomegalovirus Infection: Update on Treatment: Scientific Impact Paper No. 56. ( 29139205 )
2018
21
The Burden of Congenital Cytomegalovirus Infection: A Prospective Cohort Study of 20 000 Infants in Finland. ( 29554325 )
2018
22
Valganciclovir Is Beneficial in Children with Congenital Cytomegalovirus and Isolated Hearing Loss. ( 29605391 )
2018
23
Contribution of Breastfeeding to False Positive Saliva PCR for Newborn Congenital Cytomegalovirus Screening. ( 29401303 )
2018
24
Brain Magnetic Resonance Imaging Findings of Congenital Cytomegalovirus Infection as a Prognostic Factor for Neurological Outcome. ( 29681488 )
2018
25
Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection. ( 29894555 )
2018
26
The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review. ( 29912824 )
2018
27
Clinical factor associated with congenital cytomegalovirus infection in pregnant women with non-primary infection. ( 29735300 )
2018
28
Bronchopulmonary Dysplasia in Very Preterm Infants with Symptomatic Congenital Cytomegalovirus Infection: A Propensity Score- Matched Analysis. ( 30270170 )
2018
29
Congenital cytomegalovirus in Japan: More than 2 year follow up of infected newborns. ( 29032597 )
2018
30
Healthcare costs attributable to congenital cytomegalovirus infection. ( 29363491 )
2018
31
Reply to the Letter: "Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection". ( 29443330 )
2018
32
Maternal and child human leukocyte antigens in congenital cytomegalovirus infection. ( 29477013 )
2018
33
Congenital cytomegalovirus infection. ( 29503048 )
2018
34
Pilot Study of Model-Based Dosage Individualization of Ganciclovir in Neonates and Young Infants with Congenital Cytomegalovirus Infection. ( 29507070 )
2018
35
Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection. ( 30018143 )
2018
36
Reply to Gantt et al., "Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection". ( 30018144 )
2018
37
Impact of congenital cytomegalovirus infection on transcriptomes from archived dried blood spots in relation to long-term clinical outcome. ( 30024899 )
2018
38
Usefulness of a flow chart for targeted screening of congenital cytomegalovirus-related hearing loss. ( 30040746 )
2018
39
New findings in congenital cytomegalovirus infection: The spectrum from asymptomatic to symptomatic infection. ( 30049399 )
2018
40
Intraventricular haemorrhage as the first manifestation of congenital Cytomegalovirus infection. ( 30084424 )
2018
41
A Twenty-Year Retrospective Diagnosis of Congenital Cytomegalovirus Infection. ( 30104109 )
2018
42
Is Polymerase Chain Reaction in Neonatal Dried Blood Spots Reliable for the Diagnosis of Congenital Cytomegalovirus Infection? ( 30199483 )
2018
43
Congenital Cytomegalovirus and HIV Perinatal Transmission. ( 30216294 )
2018
44
Neuroimaging Profiles and Neurodevelopmental Outcome in Infants With Congenital Cytomegalovirus Infection. ( 30222696 )
2018
45
Congenital Cytomegalovirus Infection. ( 30257153 )
2018
46
A new era in cytomegalovirus vaccinology: considerations for rational design of next-generation vaccines to prevent congenital cytomegalovirus infection. ( 30275984 )
2018
47
Recognition, treatment, and sequelae of congenital cytomegalovirus in Australia: An observational study. ( 30300787 )
2018
48
Congenital cytomegalovirus prevention, awareness and policy recommendations - a scoping study. ( 30306881 )
2018
49
Congenital cytomegalovirus infection via a re-infected mother with original antigenic sin: A case report. ( 30339986 )
2018
50
Congenital Cytomegalovirus Infection Alters Olfaction Before Hearing Deterioration In Mice. ( 30341181 )
2018

Variations for Congenital Cytomegalovirus

Expression for Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for Congenital Cytomegalovirus

Pathways related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 CCL2 IL1B TLR2 TNF
2 12.33 CCL2 IL1B TLR2 TNF
3
Show member pathways
12.17 CCL2 IL1B TNF
4
Show member pathways
12.09 IL1B TLR2 TNF
5
Show member pathways
12.07 CCL2 IL1B TLR2 TNF
6 12.06 IL1B TLR2 TNF
7
Show member pathways
12.05 IL1B TLR2 TNF
8
Show member pathways
12.02 IL1B TLR2 TNF
9 11.92 CCL2 IL1B TNF
10
Show member pathways
11.88 IL1B TLR2 TNF
11 11.87 IL1B PPARG TNF
12
Show member pathways
11.85 IL1B TLR2 TNF
13 11.82 CCL2 IL1B TNF
14 11.79 CCL2 IL1B TNF
15 11.77 CCL2 IL1B TNF
16 11.71 CCL2 IL1B TNF
17 11.68 IL1B TLR2 TNF
18 11.58 CCL2 IL1B TLR2 TNF
19 11.57 IL1B KLRK1 TNF
20 11.45 CCL2 IL1B TNF
21 11.37 IL1B TLR2 TNF
22 11.31 CCL2 IL1B PPARG TNF
23 11.27 CCL2 IL1B TNF
24 11.16 IL1B TNF
25 11.14 IL1B TNF
26 11.11 IL1B TNF
27 11.04 CCL2 IL1B TNF
28 10.96 IL1B TNF
29 10.95 PPARG TNF
30 10.94 CCL2 IL1B TLR2
31 10.94 CCL2 IL1B TLR2 TNF
32 10.71 CCL2 IL1B KLRK1 TLR2 TNF
33 10.64 CCL2 IL1B TNF

GO Terms for Congenital Cytomegalovirus

Cellular components related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJB2 GJB6
2 connexin complex GO:0005922 8.62 GJB2 GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 CCL2 IL1B TLR2 TNF
2 negative regulation of cell proliferation GO:0008285 9.94 GJB6 IL1B PPARG TLR2
3 inflammatory response GO:0006954 9.9 CCL2 IL1B TLR2 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B TLR2 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 IL1B PPARG TNF
6 defense response to Gram-positive bacterium GO:0050830 9.76 KLRK1 TLR2 TNF
7 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 IL1B TNF
8 positive regulation of interleukin-6 production GO:0032755 9.7 IL1B TLR2 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 IL1B TLR2 TNF
10 negative regulation of vascular endothelial cell proliferation GO:1905563 9.67 CCL2 PPARG
11 negative regulation of neurogenesis GO:0050768 9.67 IL1B TNF
12 response to immobilization stress GO:0035902 9.66 IL1B PPARG
13 positive regulation of chemokine production GO:0032722 9.65 TLR2 TNF
14 microglial cell activation GO:0001774 9.65 TLR2 TNF
15 positive regulation of oligodendrocyte differentiation GO:0048714 9.64 PPARG TLR2
16 negative regulation of lipid catabolic process GO:0050995 9.63 IL1B TNF
17 positive regulation of glial cell proliferation GO:0060252 9.63 IL1B TNF
18 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B KLRK1 TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.62 IL1B TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
21 response to lipopolysaccharide GO:0032496 9.62 GJB2 GJB6 IL1B TLR2
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 CCL2 TLR2
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 IL1B KLRK1 TNF
25 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
26 regulation of establishment of endothelial barrier GO:1903140 9.57 IL1B TNF
27 cellular response to lipopolysaccharide GO:0071222 9.56 CCL2 IL1B KLRK1 TNF
28 positive regulation of neuroinflammatory response GO:0150078 9.55 IL1B TNF
29 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
30 chronic inflammatory response to antigenic stimulus GO:0002439 9.49 IL1B TNF
31 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
32 negative regulation of natural killer cell chemotaxis GO:2000502 9.4 CCL2 KLRK1
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
34 protein kinase B signaling GO:0043491 9.33 CCL2 IL1B TNF
35 positive regulation of interleukin-8 production GO:0032757 9.13 IL1B TLR2 TNF
36 lipopolysaccharide-mediated signaling pathway GO:0031663 8.92 CCL2 IL1B TLR2 TNF

Molecular functions related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CCL2 IL1B TNF

Sources for Congenital Cytomegalovirus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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