MCID: CNG069
MIFTS: 49

Congenital Cytomegalovirus

Categories: Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Congenital Cytomegalovirus

MalaCards integrated aliases for Congenital Cytomegalovirus:

Name: Congenital Cytomegalovirus 52
Congenital Cytomegalovirus Infection 71 32
Fetal Cytomegalovirus Syndrome 52 58
Mother-to-Child Transmission of Cytomegalovirus Syndrome 58
Antenatal Cytomegalovirus Infection 58
Antenatal Cmv Infection 58

Characteristics:

Orphanet epidemiological data:

58
fetal cytomegalovirus syndrome
Inheritance: Not applicable; Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases
Developmental anomalies during embryogenesis
Teratologic disorders
Rare infectious diseases


External Ids:

ICD10 32 P35.1
ICD10 via Orphanet 33 P35.1
UMLS via Orphanet 72 C0349499
Orphanet 58 ORPHA294
UMLS 71 C0158945

Summaries for Congenital Cytomegalovirus

NIH Rare Diseases : 52 Congenital cytomegalovirus (congenital CMV) is a group of symptoms that may occur when an infant is infected with the cytomegalovirus before birth. Most infants who are infected with the virus never develop symptoms of the condition. However, approximately 10% of babies will experience health problems and/or disabilities such as problems with the lungs, liver and/or spleen at birth; hearing loss ; vision loss; intellectual disability ; seizures ; small head size; and/or lack of coordination. Some babies with the condition may have evidence of infection at birth, while others may not develop symptoms for two or more years. Congenital CMV occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta . Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Congenital Cytomegalovirus, also known as congenital cytomegalovirus infection, is related to cytomegalovirus infection and sensorineural hearing loss. An important gene associated with Congenital Cytomegalovirus is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways are Measles and Herpes simplex virus 1 infection. The drugs Ganciclovir and Valganciclovir have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and placenta, and related phenotypes are sensorineural hearing impairment and abnormality of vision

Related Diseases for Congenital Cytomegalovirus

Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 477)
# Related Disease Score Top Affiliating Genes
1 cytomegalovirus infection 31.7 TNF IL1B CCL2
2 sensorineural hearing loss 30.4 TNF MT-RNR1 IL1B GJB6 GJB2
3 viral labyrinthitis 30.1 GJB6 GJB2
4 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 29.9 MT-RNR1 GJB6 GJB2
5 myocarditis 29.8 TNF IL1B CCL2
6 pendred syndrome 29.7 MT-RNR1 GJB6 GJB2
7 trichomoniasis 29.6 TNF IL1B
8 toxoplasmosis 29.5 TNF TLR2 IL1B
9 retinal vascular disease 29.5 TNF IL1B CCL2
10 perinatal necrotizing enterocolitis 28.9 TNF TLR2 IL1B
11 bacterial vaginosis 28.9 TNF TLR2 IL1B
12 lung disease 28.9 TNF TLR2 IL1B CCL2
13 pneumonia 28.6 TNF TLR2 IL1B CCL2
14 meningitis 28.6 TNF TLR2 IL1B CCL2
15 peritonitis 28.6 TNF TLR2 IL1B CCL2
16 encephalitis 28.6 TNF TLR2 IL1B CCL2
17 thrombocytopenia 28.6 TNF TLR2 IL1B CCL2
18 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
19 branchiootic syndrome 1 10.5
20 microcephaly 10.5
21 nonsyndromic hearing loss and deafness, dfna3 10.5 GJB6 GJB2
22 nonsyndromic hearing loss and deafness, dfnb1 10.5 GJB6 GJB2
23 dfnb1 10.5 GJB6 GJB2
24 pseudoainhum 10.4 GJB6 GJB2
25 purulent labyrinthitis 10.4 GJB6 GJB2
26 hydrocephalus, congenital, 1 10.4
27 chorioretinitis 10.4
28 deafness, autosomal dominant 3b 10.4 GJB6 GJB2
29 keratitis-ichthyosis-deafness syndrome, autosomal dominant 10.4 GJB6 GJB2
30 deafness, autosomal dominant 3a 10.4 GJB6 GJB2
31 knuckle pads 10.4 GJB6 GJB2
32 cerebral palsy 10.4
33 keratoderma, palmoplantar, with deafness 10.4 GJB6 GJB2
34 deafness, autosomal recessive 1b 10.4 GJB6 GJB2
35 neutropenia 10.3
36 drug-induced hearing loss 10.3 MT-RNR1 GJB2
37 deafness, autosomal recessive 26 10.3 MT-RNR1 GJB2
38 erdheim-chester disease 10.3 IL1B CCL2
39 physiological polycythemia 10.3 TNF IL1B
40 systemic onset juvenile idiopathic arthritis 10.2 TNF IL1B
41 staphylococcal toxic shock syndrome 10.2 TNF IL1B
42 polymicrogyria with or without vascular-type ehlers-danlos syndrome 10.2
43 polymicrogyria 10.2
44 vulvar vestibulitis syndrome 10.2 TNF IL1B
45 kashin-beck disease 10.2 TNF IL1B
46 schnitzler syndrome 10.2 IL1B CCL2
47 anaerobic pneumonia 10.2 TNF IL1B
48 jejunoileitis 10.2 TNF IL1B
49 metal allergy 10.2 TNF IL1B
50 actinic prurigo 10.2 TNF IL1B

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to Congenital Cytomegalovirus

Symptoms & Phenotypes for Congenital Cytomegalovirus

Human phenotypes related to Congenital Cytomegalovirus:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sensorineural hearing impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0000407
2 abnormality of vision 58 31 hallmark (90%) Very frequent (99-80%) HP:0000504
3 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
4 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
5 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
6 abnormality of coagulation 58 31 frequent (33%) Frequent (79-30%) HP:0001928
7 abnormality of the eye 58 Very frequent (99-80%)

MGI Mouse Phenotypes related to Congenital Cytomegalovirus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL2 GJB2 GJB6 IL1B PPARG RNASET2

Drugs & Therapeutics for Congenital Cytomegalovirus

Drugs for Congenital Cytomegalovirus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
2
Valganciclovir Approved, Investigational Phase 3 175865-60-8 64147
3 Ganciclovir triphosphate Phase 3
4 valacyclovir Phase 2, Phase 3
5 Immunoglobulins Phase 3
6 Antibodies Phase 3
7 Rho(D) Immune Globulin Phase 3
8 gamma-Globulins Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 Immunoglobulin G Phase 3
11 Anti-Infective Agents Phase 3
12 Antiviral Agents Phase 3
13 Pharmaceutical Solutions Phase 3
14
Mannitol Approved, Investigational Phase 2 69-65-8 6251 453
15
Povidone Approved Phase 2 9003-39-8
16 Antibodies, Monoclonal Phase 1, Phase 2
17 Sodium Benzoate Phase 2

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 The Leiden CONCERT Study 2.0 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Non-Randomized Trial With Historical Control Group Unknown status NCT02005822 Phase 3 Valganciclovir
2 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Unknown status NCT02787382 Phase 3
3 Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection Completed NCT00004278 Phase 3 ganciclovir
4 Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Completed NCT02351102 Phase 2, Phase 3 Valacyclovir;Placebo
5 A Phase III, Randomized, Placebo-Controlled Blinded Investigation of Six Weeks vs. Six Months of Oral Valganciclovir Therapy in Infants With Symptomatic Congenital Cytomegalovirus Infection (CASG 112) Completed NCT00466817 Phase 3 Valganciclovir
6 A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections. Completed NCT00001100 Phase 3 ganciclovir
7 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
8 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3 Valganciclovir
9 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Terminated NCT02606266 Phase 2, Phase 3 Valganciclovir
10 Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease Completed NCT00004642 Phase 1, Phase 2 SDZ MSL-109
11 A Phase II Randomized and Controlled Investigation of Six Weeks of Oral Valganciclovir Therapy in Infants and Children With Congenital Cytomegalovirus Infection and Hearing Loss Completed NCT01649869 Phase 2 Valganciclovir
12 A Phase I/II Pharmacokinetic and Pharmacodynamic Evaluation of Oral Valganciclovir in Neonates With Symptomatic Congenital Cytomegalovirus (CMV) Infection (CASG 109) Completed NCT00031434 Phase 1, Phase 2 Valganciclovir;Ganciclovir
13 A Phase II, Single Stage, Single-Arm Investigation of Oral Valganciclovir Therapy in Infants With Asymptomatic Congenital Cytomegalovirus Infection Recruiting NCT03301415 Phase 2 Valganciclovir
14 Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants: ValEAR Trial Recruiting NCT03107871 Phase 2 Valganciclovir;Simple Syrup
15 A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Prophylactic Cytomegalovirus Plasmid DNA Vaccine in Healthy Adults Withdrawn NCT02594566 Phase 1 CyMVectin
16 Development of Potential Biomarkers for Foetal Brain Development After Congenital CMV Infection Unknown status NCT03188679
17 A Cross-sectional Study of Congenital Cytomegalovirus Infection in Newborns in China Completed NCT02710864
18 A Cohort Study of Congenital Cytomegalovirus Infection Among Pregnant Women and Their Neonates in China Completed NCT02645396
19 Study of Maternal-foetal Cytomegalovirus (CMV) Transmission Completed NCT01251744
20 Screening for Congenital Cytomegalovirus Infection in Newborns With Failed Hearing Screen or Who Are Small for Gestational Age Completed NCT02683096
21 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Completed NCT02680743
22 The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment After Their Neonatal Screen (BEST) Completed NCT01162330
23 Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa Completed NCT03722615
24 A Follow-up Assessment of Subjects Who Received Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) During the Phase I/II Study to Evaluate the Safety and Efficacy of Ganciclovir Treatment for Congenital Cytomegalovirus (CMV) Infections Completed NCT00031421
25 Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection? Completed NCT00872703
26 Utility of Genetic Testing in Detection of Late-Onset Hearing Loss Completed NCT00511381
27 Development and Evaluation of a Clinic-Based Screening and Brief Intervention for Changing Behaviors Related to Cytomegalovirus Transmission in Pregnant Women Completed NCT01819519
28 Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital Cytomegalovirus Infection Recruiting NCT02782988
29 Incidence, Outcome and Prevention of Congenital Human Cytomegalovirus (HCMV) Infection in HCMV-seropositive Pregnant Women Recruiting NCT03973359
30 Reducing Acquisition of CMV Through Antenatal Education: A Feasibility Study to Assess an Educational Intervention to Prevent Cytomegalovirus Infection in Pregnancy Recruiting NCT03511274
31 Feasibility to Achieve, Before One Month of Age, the Diagnosis of Congenital CMV Diagnosis and the Formal Audiologic Assessment in Newborns Who Failed Newborn Hearing Screening Active, not recruiting NCT02139423
32 Evaluation of the Prognostic Value of Clinical, Imaging, Immunological and Virological Markers in the Neonatal Period for the Development of Neurosensorial Sequelae at 1 Year in Children Infected by Cytomegalovirus in Utero. Active, not recruiting NCT01923636
33 Cytomegalovirus (CMV) Vaccines: Reinfection and Antigenic Variation Not yet recruiting NCT03443791

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

MalaCards organs/tissues related to Congenital Cytomegalovirus:

40
Brain, Testes, Placenta, Liver, Lung, Spleen, Eye

Publications for Congenital Cytomegalovirus

Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 1417)
# Title Authors PMID Year
1
Indications for pediatric cochlear implantation at the University of Mississippi Medical Center. 61 54
19292131 2007
2
GJB2 and GJB6 mutations in children with congenital cytomegalovirus infection. 61 54
17426645 2007
3
Etiology of severe sensorineural hearing loss in children: independent impact of congenital cytomegalovirus infection and GJB2 mutations. 61 54
17299707 2007
4
Etiological profile of hearing loss amongst Lithuanian pediatric cochlear implant users. 61
32305661 2020
5
Should hearing targeted screening for congenital cytomegalovirus infection Be implemented? 61
32361556 2020
6
Do Antivirals Improve Hearing Outcomes in Neonates With Congenital Cytomegalovirus Infection? 61
32010980 2020
7
Neurodevelopmental outcomes of infants with congenital cytomegalovirus infection in Western Kenya. 61
32388467 2020
8
Prospective multicenter comparison of urine culture with PCR on dried blood spots using 2 different extraction and PCR methods in neonates suspected for congenital cytomegalovirus infection. 61
32408061 2020
9
Controversies in the therapeutic approach to congenital cytomegalovirus infection. 61
32125680 2020
10
Prediction of Neurodevelopmental Impairment in Congenital Cytomegalovirus Infection by Early Postnatal Magnetic Resonance Imaging. 61
32492677 2020
11
Prevention of Acquisition of Cytomegalovirus Infection in Pregnancy Through Hygiene-based Behavioral Interventions: A Systematic Review and Gap Analysis. 61
32502127 2020
12
Targeted and universal screen in term and preterm infants for congenital CMV infection. 61
32552285 2020
13
Immune Monitoring Using QuantiFERON®-CMV Assay in Congenital Cytomegalovirus Infection: Correlation With Clinical Presentation and CMV DNA load. 61
32504086 2020
14
Cotton wool balls are an effective urine collection tool for CMV PCR for diagnosing congenital cytomegalovirus infection. 61
32334829 2020
15
Utilizing Community Engagement Studios to inform patient experience in a multicenter randomized control trial. 61
32208178 2020
16
Congenital CMV-Coded Diagnosis Among American Indian and Alaska Native Infants in the United States, 2000-2017. 61
32424641 2020
17
Is it time for routine prenatal serological screening for congenital cytomegalovirus? 61
32459019 2020
18
Low birth weight and head circumference as potential biomarkers of sensorineural hearing loss in asymptomatic congenitally CMV-infected infants. 61
32521464 2020
19
Clinical profile of symptomatic congenital cytomegalovirus infection: cases from a tertiary hospital in north India. 61
32437297 2020
20
Therapeutic challenges and clinical characteristics of single-sided deafness in children. 61
32502913 2020
21
Etiology of Prelingual Hearing Loss in the Universal Newborn Hearing Screening Era: A Scoping Review. 61
32423335 2020
22
Congenital Cytomegalovirus and Hearing Loss. 61
32259513 2020
23
Congenital infections as contributors to the onset of diabetes in children: A longitudinal study in the United States, 2001-2017. 61
31820549 2020
24
Diagnosing congenital cytomegalovirus by saliva on Guthrie paper. 61
32302951 2020
25
Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection. 61
32466137 2020
26
Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study. 61
31927626 2020
27
Utility of two DNA extraction methods using formalin-fixed paraffin-embedded tissues in identifying congenital cytomegalovirus infection by polymerase chain reaction. 61
32534239 2020
28
Congenital Cytomegalovirus and Autoimmune Neutropenia: Cause or Coincidence? 61
31990888 2020
29
Management of cytomegalovirus infection in pregnancy: is it time for valacyclovir? 61
32289479 2020
30
Retrospectively diagnosing congenital cytomegalovirus infections in symptomatic infants is challenging. 61
32281152 2020
31
Outcome and management of newborns with congenital cytomegalovirus infection. 61
32127242 2020
32
[Therapy Options for Infants with Congenital Cytomegalovirus Infection - Implications for Setting Up Neonatal Screening Programs]. 61
31426118 2020
33
Different Audiologic Outcomes in Twins with Congenital Cytomegalovirus Infection. 61
32209524 2020
34
Congenital Cytomegalovirus and Zika Infections. 61
32281058 2020
35
Middle Ear Effusion in Children With Congenital Cytomegalovirus Infection. 61
31876611 2020
36
Efficacy and safety of valganciclovir in patients with symptomatic congenital cytomegalovirus disease: Study Protocol Clinical Trial (SPIRIT Compliant). 61
32332615 2020
37
Antenatal imaging and clinical outcome in congenital CMV infection: A field-wide systematic review and meta-analysis. 61
32097687 2020
38
A cohort study of the universal neonatal urine screening for congenital cytomegalovirus infection. 61
32273174 2020
39
Cytomegalovirus DNA in the nails of an infant diagnosed with a congenital cytomegalovirus infection. 61
32349916 2020
40
Human Cytomegalovirus Congenital (cCMV) Infection Following Primary and Nonprimary Maternal Infection: Perspectives of Prevention through Vaccine Development. 61
32340180 2020
41
Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells. 61
32068527 2020
42
Natural History of Congenital Cytomegalovirus Infection in Highly Seropositive Populations. 61
32134482 2020
43
Diagnosis and medical care for congenital cytomegalovirus infection: An observational study using claims data in Japan, 2010 to 2017. 61
32150093 2020
44
Contribution of Congenital Cytomegalovirus Infection to Permanent Hearing Loss in a Highly Seropositive Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study. 61
31102409 2020
45
Congenital Cytomegalovirus Infection. 61
32134480 2020
46
Diagnosing congenital Cytomegalovirus infection: don't get rid of dried blood spots. 61
32164599 2020
47
Prenatal Treatment of Congenital Cytomegalovirus with Valganciclovir: a Case Report. 61
32198512 2020
48
A Cross-Sectional Study of Caregiver Perceptions of Congenital Cytomegalovirus Infection: Knowledge and Attitudes about Screening. 61
31952844 2020
49
Mothers' knowledge about congenital cytomegalovirus infection is associated with desire for infants' screening. 61
32089174 2020
50
Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development. 61
32134481 2020

Variations for Congenital Cytomegalovirus

Expression for Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for Congenital Cytomegalovirus

Pathways related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 TNF TLR2 IL1B CCL2
2 12.59 TNF TLR2 IL1B CCL2
3 12.31 TNF TLR2 IL1B CCL2
4
Show member pathways
12.09 TNF TLR2 IL1B
5 12.07 TNF IL1B CCL2
6 12.06 TNF TLR2 IL1B
7
Show member pathways
12.04 TNF TLR2 IL1B CCL2
8
Show member pathways
12.01 TNF TLR2 IL1B
9 11.91 TNF IL1B CCL2
10 11.87 TNF PPARG IL1B
11 11.83 TNF IL1B CCL2
12 11.82 TNF IL1B CCL2
13 11.79 TNF IL1B CCL2
14 11.77 TNF IL1B CCL2
15
Show member pathways
11.74 TNF TLR2 IL1B
16 11.71 TNF TLR2 IL1B
17 11.69 TNF IL1B CCL2
18 11.56 TNF KLRK1 IL1B
19 11.53 TNF TLR2 IL1B CCL2
20 11.43 TNF IL1B CCL2
21 11.36 TNF TLR2 IL1B
22 11.23 TNF IL1B CCL2
23 10.95 TNF PPARG
24 10.95 TNF IL1B
25 10.94 TNF TLR2 IL1B CCL2
26 10.9 TLR2 IL1B CCL2
27 10.72 TNF TLR2 KLRK1 IL1B CCL2
28 10.54 TNF IL1B CCL2

GO Terms for Congenital Cytomegalovirus

Cellular components related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 connexin complex GO:0005922 8.62 GJB6 GJB2

Biological processes related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 TNF TLR2 IL1B CCL2
2 negative regulation of cell proliferation GO:0008285 9.96 TLR2 PPARG IL1B GJB6
3 inflammatory response GO:0006954 9.92 TNF TLR2 IL1B CCL2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 TNF TLR2 IL1B
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.79 TNF PPARG IL1B
6 defense response to Gram-positive bacterium GO:0050830 9.78 TNF TLR2 KLRK1
7 positive regulation of inflammatory response GO:0050729 9.77 TNF TLR2 IL1B
8 cellular response to organic cyclic compound GO:0071407 9.73 TNF IL1B CCL2
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 TNF TLR2 IL1B
10 positive regulation of interleukin-6 production GO:0032755 9.69 TNF TLR2 IL1B
11 positive regulation of oligodendrocyte differentiation GO:0048714 9.68 TLR2 PPARG
12 regulation of fat cell differentiation GO:0045598 9.67 TNF PPARG
13 positive regulation of chemokine production GO:0032722 9.67 TNF TLR2
14 cellular response to lipopolysaccharide GO:0071222 9.67 TNF KLRK1 IL1B CCL2
15 positive regulation of glial cell proliferation GO:0060252 9.66 TNF IL1B
16 positive regulation of interleukin-8 secretion GO:2000484 9.65 TNF TLR2
17 negative regulation of lipid catabolic process GO:0050995 9.65 TNF IL1B
18 astrocyte activation GO:0048143 9.65 TNF IL1B
19 positive regulation of interferon-gamma production GO:0032729 9.65 TNF KLRK1 IL1B
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 TNF IL1B
21 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.64 TNF IL1B
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR2 CCL2
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 TNF KLRK1 IL1B
25 positive regulation of chemokine biosynthetic process GO:0045080 9.61 TNF IL1B
26 positive regulation of neuroinflammatory response GO:0150078 9.6 TNF IL1B
27 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
28 gap junction assembly GO:0016264 9.58 GJB6 GJB2
29 cell communication by electrical coupling GO:0010644 9.57 GJB6 GJB2
30 response to lipopolysaccharide GO:0032496 9.56 TLR2 IL1B GJB6 GJB2
31 gap junction-mediated intercellular transport GO:1990349 9.55 GJB6 GJB2
32 positive regulation of fever generation GO:0031622 9.52 TNF IL1B
33 positive regulation of interleukin-6 secretion GO:2000778 9.5 TNF TLR2 IL1B
34 sequestering of triglyceride GO:0030730 9.49 TNF IL1B
35 negative regulation of natural killer cell chemotaxis GO:2000502 9.43 KLRK1 CCL2
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IL1B
37 protein kinase B signaling GO:0043491 9.33 TNF IL1B CCL2
38 positive regulation of interleukin-8 production GO:0032757 9.13 TNF TLR2 IL1B
39 lipopolysaccharide-mediated signaling pathway GO:0031663 8.92 TNF TLR2 IL1B CCL2

Molecular functions related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.96 GJB6 GJB2
2 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.62 GJB6 GJB2

Sources for Congenital Cytomegalovirus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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