MCID: CNG069
MIFTS: 38

Congenital Cytomegalovirus

Categories: Rare diseases

Aliases & Classifications for Congenital Cytomegalovirus

MalaCards integrated aliases for Congenital Cytomegalovirus:

Name: Congenital Cytomegalovirus 53
Congenital Cytomegalovirus Infection 73

Classifications:



External Ids:

UMLS 73 C0158945

Summaries for Congenital Cytomegalovirus

NIH Rare Diseases : 53 Congenital cytomegalovirus (congenital CMV) is a group of symptoms that may occur when an infant is infected with the cytomegalovirus before birth. Most infants who are infected with the virus never develop symptoms of the condition. However, approximately 10% of babies will experience health problems and/or disabilities such as problems with the lungs, liver and/or spleen at birth; hearing loss; vision loss; intellectual disability; seizures; small head size; and/or lack of coordination. Some babies with the condition may have evidence of infection at birth, while others may not develop symptoms for two or more years. Congenital CMV occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta. Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Congenital Cytomegalovirus, also known as congenital cytomegalovirus infection, is related to deafness, autosomal recessive 4, with enlarged vestibular aqueduct and cytomegalovirus infection. An important gene associated with Congenital Cytomegalovirus is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways are Gap junction trafficking and Malaria. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and placenta.

Related Diseases for Congenital Cytomegalovirus

Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 29.3 GJB2 GJB6
2 cytomegalovirus infection 10.9
3 deafness, autosomal dominant 24 10.4 GJB2 GJB6
4 kid syndrome 10.4 GJB2 GJB6
5 pseudoainhum 10.4 GJB2 GJB6
6 knuckle pads, leukonychia, and sensorineural deafness 10.4 GJB2 GJB6
7 deafness, x-linked 2 10.4 GJB2 GJB6
8 dfnb1 10.4 GJB2 GJB6
9 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
10 vohwinkel syndrome 10.4 GJB2 GJB6
11 deafness, autosomal recessive 1a 10.3 GJB2 GJB6
12 deafness, autosomal recessive 23 10.3 GJB2 GJB6
13 knuckle pads 10.3 GJB2 GJB6
14 vestibular disease 10.3 GJB2 GJB6
15 deafness, autosomal dominant 2a 10.2 GJB2 GJB6
16 deafness, autosomal recessive 16 10.2 GJB2 GJB6
17 sensorineural hearing loss 10.2
18 deafness, autosomal recessive 7 10.2 GJB2 MT-RNR1
19 erythrokeratodermia variabilis et progressiva 1 10.2 GJB2 GJB6
20 deafness, autosomal dominant 36 10.2 GJB2 MT-RNR1
21 autosomal dominant non-syndromic sensorineural deafness type dfna 10.1 GJB2 GJB6
22 clouston syndrome 10.1 GJB2 GJB6
23 deafness, autosomal recessive 30 10.1 GJB2 MT-RNR1
24 idiopathic bilateral vestibulopathy 10.0 MT-RNR1 RNR1
25 cerebritis 10.0
26 fetal cytomegalovirus syndrome 10.0
27 aging 9.9
28 autism 9.9
29 cerebral palsy 9.9
30 corneal disease 9.9 GJB2 GJB6
31 hepatitis 9.8
32 retinitis 9.8
33 chorioretinitis 9.8
34 skin disease 9.8 GJB2 GJB6 PPARG
35 cytomegalovirus retinitis 9.8
36 hodgkin's lymphoma, nodular sclerosis 9.7 GJB2 GJB6 MT-RNR1
37 inner ear disease 9.7 GJB2 GJB6 MT-RNR1
38 auditory system disease 9.7 GJB2 GJB6 MT-RNR1
39 cortical dysplasia, complex, with other brain malformations 7 9.7
40 pulmonary hypertension 9.7
41 twin-to-twin transfusion syndrome 9.7
42 hydrocephalus 9.7
43 autism spectrum disorder 9.7
44 oligohydramnios 9.7
45 periventricular leukomalacia 9.7
46 labyrinthitis 9.7
47 pneumonia 9.7
48 leukomalacia 9.7
49 neonatal herpes 9.7
50 autosomal recessive non-syndromic sensorineural deafness type dfnb 9.6 GJB2 GJB6

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to Congenital Cytomegalovirus

Symptoms & Phenotypes for Congenital Cytomegalovirus

Drugs & Therapeutics for Congenital Cytomegalovirus

Drugs for Congenital Cytomegalovirus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4,Phase 2,Phase 3 59277-89-3 2022
2 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
4 valacyclovir Phase 4,Phase 2,Phase 3
5
Ganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 82410-32-0 3454
6
Valganciclovir Approved, Investigational Phase 3,Phase 2,Phase 1 175865-60-8 64147
7
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
8
Povidone Approved Phase 3 9003-39-8
9 Rho(D) Immune Globulin Phase 3,Not Applicable
10 gamma-Globulins Phase 3,Not Applicable
11 Ganciclovir triphosphate Phase 3,Phase 2,Phase 1
12 Pharmaceutical Solutions Phase 3,Phase 2
13 Antibodies Phase 3,Phase 1,Phase 2,Not Applicable
14 Immunoglobulins Phase 3,Phase 1,Phase 2,Not Applicable
15 Immunoglobulins, Intravenous Phase 3,Not Applicable
16 Sodium Benzoate Phase 3
17 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
18 Immunoglobulin G Phase 3
19 MF59 oil emulsion Phase 2
20 Vaccines Phase 2,Phase 1
21 Antibodies, Monoclonal Phase 1, Phase 2
22 Krestin

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 In UTERO Treatment of Cytomegalovirus Congenital Infection With Valacyclovir Terminated NCT01037712 Phase 4 Valacyclovir (ZELITREX);Placebo
2 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment Unknown status NCT02005822 Phase 3 Valganciclovir
3 A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections. Completed NCT00001100 Phase 3 ganciclovir
4 Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection Completed NCT00004278 Phase 3 ganciclovir
5 Short-Term vs. Long-Term Valganciclovir Therapy for Symptomatic Congenital CMV Infections Completed NCT00466817 Phase 3 Valganciclovir
6 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Recruiting NCT02606266 Phase 2, Phase 3 Valganciclovir
7 Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Recruiting NCT02351102 Phase 2, Phase 3 Valacyclovir;Placebo
8 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
9 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
10 Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants Not yet recruiting NCT03107871 Phase 3 Valganciclovir;Simple Syrup
11 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3 Valganciclovir
12 Valganciclovir in Congenital CMV Infants Completed NCT00031434 Phase 1, Phase 2 Valganciclovir;Ganciclovir
13 Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease Completed NCT00004642 Phase 1, Phase 2 SDZ MSL-109
14 Recombinant CMV gB Vaccine in Postpartum Women Completed NCT00125502 Phase 2 MF59 adjuvant;Placebo
15 Valganciclovir Therapy in Infants and Children With Congenital CMV Infection and Hearing Loss Recruiting NCT01649869 Phase 2 Valganciclovir
16 Asymptomatic Congenital CMV Treatment Not yet recruiting NCT03301415 Phase 2 Valganciclovir
17 Safety, Tolerability, and Immunogenicity of a Cytomegalovirus DNA Vaccine Withdrawn NCT02594566 Phase 1 CyMVectin
18 Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women With Primary Cytomegalovirus Infection Unknown status NCT01659684 Not Applicable
19 Genotyping of Cytomegalovirus From Patients in Israel Unknown status NCT00228202
20 Screening for Congenital Cytomegalovirus Infection in Newborns Completed NCT02683096
21 A Cross-sectional Study of Congenital Cytomegalovirus Infection in Newborns in China Completed NCT02710864
22 The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment Completed NCT01162330
23 Clinical Trial of Behavioral Modification to Prevent Congenital Cytomegalovirus Completed NCT01819519 Not Applicable
24 Neonatal CMV-Ganciclovir Follow-up Study Completed NCT00031421
25 Study of the Transmission of Cytomegalovirus (CMV) Infection From Mother to Foetus Completed NCT01251744 Not Applicable
26 Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection? Completed NCT00872703
27 Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital CMV Recruiting NCT02782988
28 Reducing Acquisition of CMV Through Antenatal Education Recruiting NCT03511274 Not Applicable
29 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Recruiting NCT02680743 Not Applicable
30 Biomarkers of Cytomegalovirus Fetal Infection and Disease Recruiting NCT03090841
31 Immunological Characteristics of Maternal-fetal Transmission of Cytomegalovirus in Pregnancy Recruiting NCT02129465
32 Relevance of Gastric Aspirate in HCMV Detection Recruiting NCT03262194
33 Diagnosis of Congenital CMV Infection in Neonates Who Failed Newborn Hearing Screening Active, not recruiting NCT02139423 Not Applicable
34 Prognostic Value of Neonatal Markers for the Development of Neurosensorial Sequelae in Children Infected by Cytomegalovirus in Utero Active, not recruiting NCT01923636 Not Applicable
35 A Cohort Study of Cytomegalovirus(CMV) Infection Among Pregnant Women and Their Newborns in China Active, not recruiting NCT02645396
36 Development of Potential Biomarkers for Foetal Brain Development After Congenital CMV Infection Not yet recruiting NCT03188679 Not Applicable
37 Cytomegalovirus (CMV) Vaccines: Reinfection and Antigenic Variation Not yet recruiting NCT03443791 Not Applicable

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

MalaCards organs/tissues related to Congenital Cytomegalovirus:

41
Liver, Lung, Placenta, Spleen, Brain, Testes, T Cells

Publications for Congenital Cytomegalovirus

Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 663)
# Title Authors Year
1
Congenital cytomegalovirus, parvovirus and enterovirus infection in Mozambican newborns at birth: A cross-sectional survey. ( 29538464 )
2018
2
Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection. ( 29784513 )
2018
3
Risk Factors, Geographic Distribution, and Healthcare Burden of Symptomatic Congenital Cytomegalovirus Infection in the United States: Analysis of a Nationally Representative Database, 2000-2012. ( 29706491 )
2018
4
Hearing Trajectory in Children with Congenital Cytomegalovirus Infection. ( 29557247 )
2018
5
Unusual complication of fulminant congenital cytomegalovirus infection. ( 29843259 )
2018
6
Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection. ( 29359492 )
2018
7
Hematologic Adverse Events Associated with Prolonged Valganciclovir Treatment in Congenital Cytomegalovirus Infection. ( 29677086 )
2018
8
Neonates with congenital Cytomegalovirus and hearing loss identified via the universal newborn hearing screening program. ( 29571077 )
2018
9
Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections. ( 29343580 )
2018
10
Viral Loads in Congenital Cytomegalovirus Infection From a Highly Immune Population. ( 29860410 )
2018
11
Does screening for congenital cytomegalovirus at birth improve longer term hearing outcomes? ( 29705727 )
2018
12
Cochlear implant performance in children deafened by congenital cytomegalovirus-A systematic review. ( 29768731 )
2018
13
A rational approach to identifying newborns with hearing loss caused by congenital cytomegalovirus infection by dried blood spot screening. ( 29513124 )
2018
14
Congenital Cytomegalovirus Infection Presenting with Isolated Secretory Diarrhoea Mimicking a Congenital Diarrhoeal Disorder. ( 29611315 )
2018
15
Congenital cytomegalovirus pneumonitis and treatment response evaluation using viral load during ganciclovir therapy: a case report. ( 29709989 )
2018
16
Results of a Targeted Screening Program for Congenital Cytomegalovirus Infection in Infants Who Fail Newborn Hearing Screening. ( 29373759 )
2018
17
Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection. ( 29441223 )
2018
18
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
19
Closer to Universal Newborn Screening for Congenital Cytomegalovirus Infection but Far Away from Antiviral Therapy in All Infected Infants. ( 29703574 )
2018
20
Congenital Cytomegalovirus Infection: Update on Treatment: Scientific Impact Paper No. 56. ( 29139205 )
2018
21
The Burden of Congenital Cytomegalovirus Infection: A Prospective Cohort Study of 20 000 Infants in Finland. ( 29554325 )
2018
22
Valganciclovir Is Beneficial in Children with Congenital Cytomegalovirus and Isolated Hearing Loss. ( 29605391 )
2018
23
Contribution of Breastfeeding to False Positive Saliva PCR for Newborn Congenital Cytomegalovirus Screening. ( 29401303 )
2018
24
Brain Magnetic Resonance Imaging Findings of Congenital Cytomegalovirus Infection as a Prognostic Factor for Neurological Outcome. ( 29681488 )
2018
25
Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection. ( 29894555 )
2018
26
The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review. ( 29912824 )
2018
27
Clinical factor associated with congenital cytomegalovirus infection in pregnant women with non-primary infection. ( 29735300 )
2018
28
Healthcare costs attributable to congenital cytomegalovirus infection. ( 29363491 )
2018
29
Reply to the Letter: "Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection". ( 29443330 )
2018
30
Congenital Cytomegalovirus Infection: Child Development, Quality of Life and Impact on Daily Life. ( 28650934 )
2017
31
Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management. ( 29140947 )
2017
32
A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening. ( 28049114 )
2017
33
Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. ( 28679960 )
2017
34
Intelligence and Academic Achievement With Asymptomatic Congenital Cytomegalovirus Infection. ( 29066580 )
2017
35
Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis. ( 29185167 )
2017
36
Symptomatic congenital Cytomegalovirus deafness: the impact of a six-week course of antiviral treatment on hearing improvement. ( 29286014 )
2017
37
Congenital cytomegalovirus - who, when, what-with and why to treat? ( 28646968 )
2017
38
Neonatal screening parameters in infants with congenital Cytomegalovirus infection. ( 28847685 )
2017
39
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
40
Pathogenesis of developmental anomalies of the central nervous system induced by congenital cytomegalovirus infection. ( 28074532 )
2017
41
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection. ( 27843092 )
2017
42
Immune responses to congenital cytomegalovirus infection. ( 29287989 )
2017
43
Preventing Congenital Cytomegalovirus Infection. ( 28825308 )
2017
44
Congenital cytomegalovirus and infantile neutropaenia: A causal relationship? ( 28786201 )
2017
45
Screening for Congenital Cytomegalovirus Is Recommended in Every Newborn. ( 29151083 )
2017
46
Management and outcomes of cochlear implantation in patients with congenital cytomegalovirus (cCMV)-related deafness. ( 28485697 )
2017
47
Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss. ( 28501927 )
2017
48
Screening for seemingly healthy newborns with congenital cytomegalovirus infection by quantitative real-time polymerase chain reaction using newborn urine: an observational study. ( 28110288 )
2017
49
Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study. ( 28056855 )
2017
50
Hyperimmune globulin in pregnancy for the prevention of congenital cytomegalovirus disease. ( 29072089 )
2017

Variations for Congenital Cytomegalovirus

Expression for Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for Congenital Cytomegalovirus

Pathways related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.95 GJB2 GJB6
2 10.31 KLRK1 TLR2

GO Terms for Congenital Cytomegalovirus

Cellular components related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 GJB2 TLR2
2 gap junction GO:0005921 8.96 GJB2 GJB6
3 connexin complex GO:0005922 8.62 GJB2 GJB6

Biological processes related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.58 GJB6 PPARG TLR2
2 defense response to Gram-positive bacterium GO:0050830 9.43 KLRK1 TLR2
3 inner ear development GO:0048839 9.37 GJB2 GJB6
4 cell communication GO:0007154 9.32 GJB2 GJB6
5 response to retinoic acid GO:0032526 9.26 GJB2 PPARG
6 response to progesterone GO:0032570 9.16 GJB2 TLR2
7 response to lipopolysaccharide GO:0032496 9.13 GJB2 GJB6 TLR2
8 positive regulation of oligodendrocyte differentiation GO:0048714 8.62 PPARG TLR2

Sources for Congenital Cytomegalovirus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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