MCID: CNG069
MIFTS: 49

Congenital Cytomegalovirus

Categories: Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Congenital Cytomegalovirus

MalaCards integrated aliases for Congenital Cytomegalovirus:

Name: Congenital Cytomegalovirus 52
Congenital Cytomegalovirus Infection 71 32
Fetal Cytomegalovirus Syndrome 52 58
Mother-to-Child Transmission of Cytomegalovirus Syndrome 58
Antenatal Cytomegalovirus Infection 58
Antenatal Cmv Infection 58

Characteristics:

Orphanet epidemiological data:

58
fetal cytomegalovirus syndrome
Inheritance: Not applicable; Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases
Developmental anomalies during embryogenesis
Teratologic disorders
Rare infectious diseases


External Ids:

ICD10 32 P35.1
ICD10 via Orphanet 33 P35.1
UMLS via Orphanet 72 C0349499
Orphanet 58 ORPHA294
UMLS 71 C0158945

Summaries for Congenital Cytomegalovirus

NIH Rare Diseases : 52 Congenital cytomegalovirus (congenital CMV) is a group of symptoms that may occur when an infant is infected with the cytomegalovirus before birth. Most infants who are infected with the virus never develop symptoms of the condition. However, approximately 10% of babies will experience health problems and/or disabilities such as problems with the lungs, liver and/or spleen at birth; hearing loss ; vision loss; intellectual disability ; seizures ; small head size; and/or lack of coordination. Some babies with the condition may have evidence of infection at birth, while others may not develop symptoms for two or more years. Congenital CMV occurs when a mother is infected with cytomegalovirus during pregnancy and passes the infection to the fetus through the placenta . Treatment is based on the signs and symptoms present in each person.

MalaCards based summary : Congenital Cytomegalovirus, also known as congenital cytomegalovirus infection, is related to cytomegalovirus infection and labyrinthitis. An important gene associated with Congenital Cytomegalovirus is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways are Measles and Herpes simplex virus 1 infection. The drugs Ganciclovir and Valganciclovir have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related phenotypes are sensorineural hearing impairment and abnormality of vision

Related Diseases for Congenital Cytomegalovirus

Diseases related to Congenital Cytomegalovirus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 420)
# Related Disease Score Top Affiliating Genes
1 cytomegalovirus infection 31.7 TNF IL1B CCL2
2 labyrinthitis 30.5 GJB6 GJB2
3 sensorineural hearing loss 30.4 TNF MT-RNR1 IL1B GJB6 GJB2
4 viral labyrinthitis 30.1 GJB6 GJB2
5 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 29.9 MT-RNR1 GJB6 GJB2
6 myocarditis 29.8 TNF IL1B CCL2
7 encephalitis 29.7 TNF IL1B CCL2
8 nonsyndromic deafness 29.7 MT-RNR1 GJB6 GJB2
9 pendred syndrome 29.7 MT-RNR1 GJB6 GJB2
10 toxoplasmosis 29.5 TNF TLR2 IL1B
11 retinal vascular disease 29.5 TNF IL1B CCL2
12 thrombocytopenia 29.4 TNF TLR2 IL1B CCL2
13 perinatal necrotizing enterocolitis 28.9 TNF TLR2 IL1B
14 bacterial vaginosis 28.9 TNF TLR2 IL1B
15 lung disease 28.9 TNF TLR2 IL1B CCL2
16 pneumonia 28.8 TNF TLR2 IL1B CCL2
17 meningitis 28.6 TNF TLR2 IL1B CCL2
18 peritonitis 28.6 TNF TLR2 IL1B CCL2
19 diabetes mellitus 28.0 TNF TLR2 PPARG IL1B CCL2
20 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
21 branchiootic syndrome 1 10.5
22 microcephaly 10.5
23 nonsyndromic hearing loss and deafness, dfna3 10.5 GJB6 GJB2
24 nonsyndromic hearing loss and deafness, dfnb1 10.5 GJB6 GJB2
25 dfnb1 10.5 GJB6 GJB2
26 deafness, autosomal dominant 24 10.4 GJB6 GJB2
27 pseudoainhum 10.4 GJB6 GJB2
28 purulent labyrinthitis 10.4 GJB6 GJB2
29 deafness, autosomal recessive 1b 10.4 GJB6 GJB2
30 deafness, x-linked 2 10.4 GJB6 GJB2
31 deafness, autosomal dominant 3b 10.4 GJB6 GJB2
32 keratitis-ichthyosis-deafness syndrome, autosomal dominant 10.4 GJB6 GJB2
33 deafness, autosomal dominant 64 10.4 GJB6 GJB2
34 hydrocephalus, congenital, 1 10.4
35 chorioretinitis 10.4
36 deafness, autosomal dominant 59 10.4 GJB6 GJB2
37 deafness, autosomal dominant 3a 10.4 GJB6 GJB2
38 knuckle pads 10.4 GJB6 GJB2
39 knuckle pads, leukonychia, and sensorineural deafness 10.4 GJB6 GJB2
40 vohwinkel syndrome 10.4 GJB6 GJB2
41 cerebral palsy 10.4
42 neutropenia 10.3
43 deafness, autosomal recessive 26 10.3 MT-RNR1 GJB2
44 clouston syndrome 10.3 GJB6 GJB2
45 systemic onset juvenile idiopathic arthritis 10.2 TNF IL1B
46 staphylococcal toxic shock syndrome 10.2 TNF IL1B
47 vulvar vestibulitis syndrome 10.2 TNF IL1B
48 polymicrogyria with or without vascular-type ehlers-danlos syndrome 10.2
49 polymicrogyria 10.2
50 kashin-beck disease 10.2 TNF IL1B

Graphical network of the top 20 diseases related to Congenital Cytomegalovirus:



Diseases related to Congenital Cytomegalovirus

Symptoms & Phenotypes for Congenital Cytomegalovirus

Human phenotypes related to Congenital Cytomegalovirus:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sensorineural hearing impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0000407
2 abnormality of vision 58 31 hallmark (90%) Very frequent (99-80%) HP:0000504
3 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
4 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
5 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
6 abnormality of coagulation 58 31 frequent (33%) Frequent (79-30%) HP:0001928
7 abnormality of the eye 58 Very frequent (99-80%)

MGI Mouse Phenotypes related to Congenital Cytomegalovirus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL2 GJB2 GJB6 IL1B PPARG RNASET2

Drugs & Therapeutics for Congenital Cytomegalovirus

Drugs for Congenital Cytomegalovirus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 3 82410-32-0 3454
2
Valganciclovir Approved, Investigational Phase 3 175865-60-8 64147
3 Ganciclovir triphosphate Phase 3
4 valacyclovir Phase 2, Phase 3
5 Immunoglobulins Phase 3
6 Antibodies Phase 3
7 Immunoglobulin G Phase 3
8 Rho(D) Immune Globulin Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 gamma-Globulins Phase 3
11 Anti-Infective Agents Phase 3
12 Antiviral Agents Phase 3
13 Pharmaceutical Solutions Phase 3
14
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
15
Povidone Approved Phase 2 9003-39-8
16 Antibodies, Monoclonal Phase 1, Phase 2
17 Sodium Benzoate Phase 2
18 Immunologic Factors

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 The Leiden CONCERT Study 2.0 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Non-Randomized Trial With Historical Control Group Unknown status NCT02005822 Phase 3 Valganciclovir
2 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Unknown status NCT02787382 Phase 3
3 Phase III Randomized, Controlled Study of Ganciclovir for Symptomatic Congenital Cytomegalovirus Infection Completed NCT00004278 Phase 3 ganciclovir
4 Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Completed NCT02351102 Phase 2, Phase 3 Valacyclovir;Placebo
5 A Phase III, Randomized, Placebo-Controlled Blinded Investigation of Six Weeks vs. Six Months of Oral Valganciclovir Therapy in Infants With Symptomatic Congenital Cytomegalovirus Infection (CASG 112) Completed NCT00466817 Phase 3 Valganciclovir
6 A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections. Completed NCT00001100 Phase 3 ganciclovir
7 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
8 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3 Valganciclovir
9 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Terminated NCT02606266 Phase 2, Phase 3 Valganciclovir
10 Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease Completed NCT00004642 Phase 1, Phase 2 SDZ MSL-109
11 A Phase II Randomized and Controlled Investigation of Six Weeks of Oral Valganciclovir Therapy in Infants and Children With Congenital Cytomegalovirus Infection and Hearing Loss Completed NCT01649869 Phase 2 Valganciclovir
12 A Phase I/II Pharmacokinetic and Pharmacodynamic Evaluation of Oral Valganciclovir in Neonates With Symptomatic Congenital Cytomegalovirus (CMV) Infection (CASG 109) Completed NCT00031434 Phase 1, Phase 2 Valganciclovir;Ganciclovir
13 A Phase II, Single Stage, Single-Arm Investigation of Oral Valganciclovir Therapy in Infants With Asymptomatic Congenital Cytomegalovirus Infection Recruiting NCT03301415 Phase 2 Valganciclovir
14 Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants: ValEAR Trial Recruiting NCT03107871 Phase 2 Valganciclovir;Simple Syrup
15 A Phase 1 Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Prophylactic Cytomegalovirus Plasmid DNA Vaccine in Healthy Adults Withdrawn NCT02594566 Phase 1 CyMVectin
16 Development of Potential Biomarkers for Foetal Brain Development After Congenital CMV Infection Unknown status NCT03188679
17 A Cross-sectional Study of Congenital Cytomegalovirus Infection in Newborns in China Completed NCT02710864
18 A Cohort Study of Congenital Cytomegalovirus Infection Among Pregnant Women and Their Neonates in China Completed NCT02645396
19 Study of Maternal-foetal Cytomegalovirus (CMV) Transmission Completed NCT01251744
20 Screening for Congenital Cytomegalovirus Infection in Newborns With Failed Hearing Screen or Who Are Small for Gestational Age Completed NCT02683096
21 Cytomegalovirus Testing and Intervention Protocol for Newborn Nursery and Newborn Intensive Care Unit Completed NCT02680743
22 The Benefits Feasibility and Acceptability of Extended Screening Testing in Newborn Babies Who Are Referred for Further Hearing Assessment After Their Neonatal Screen (BEST) Completed NCT01162330
23 Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa Completed NCT03722615
24 A Follow-up Assessment of Subjects Who Received Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) During the Phase I/II Study to Evaluate the Safety and Efficacy of Ganciclovir Treatment for Congenital Cytomegalovirus (CMV) Infections Completed NCT00031421
25 Does Normal Brain Imaging Predict Normal Neurodevelopmental Outcome in Fetuses With Proven Cytomegalovirus Infection? Completed NCT00872703
26 Utility of Genetic Testing in Detection of Late-Onset Hearing Loss Completed NCT00511381
27 Development and Evaluation of a Clinic-Based Screening and Brief Intervention for Changing Behaviors Related to Cytomegalovirus Transmission in Pregnant Women Completed NCT01819519
28 Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital Cytomegalovirus Infection Recruiting NCT02782988
29 Incidence, Outcome and Prevention of Congenital Human Cytomegalovirus (HCMV) Infection in HCMV-seropositive Pregnant Women Recruiting NCT03973359
30 Reducing Acquisition of CMV Through Antenatal Education: A Feasibility Study to Assess an Educational Intervention to Prevent Cytomegalovirus Infection in Pregnancy Recruiting NCT03511274
31 Feasibility to Achieve, Before One Month of Age, the Diagnosis of Congenital CMV Diagnosis and the Formal Audiologic Assessment in Newborns Who Failed Newborn Hearing Screening Active, not recruiting NCT02139423
32 Evaluation of the Prognostic Value of Clinical, Imaging, Immunological and Virological Markers in the Neonatal Period for the Development of Neurosensorial Sequelae at 1 Year in Children Infected by Cytomegalovirus in Utero. Active, not recruiting NCT01923636
33 Cytomegalovirus (CMV) Vaccines: Reinfection and Antigenic Variation Not yet recruiting NCT03443791

Search NIH Clinical Center for Congenital Cytomegalovirus

Genetic Tests for Congenital Cytomegalovirus

Anatomical Context for Congenital Cytomegalovirus

MalaCards organs/tissues related to Congenital Cytomegalovirus:

40
Brain, Liver, Lung, Placenta, Testes, Spleen, Heart

Publications for Congenital Cytomegalovirus

Articles related to Congenital Cytomegalovirus:

(show top 50) (show all 1363)
# Title Authors PMID Year
1
Indications for pediatric cochlear implantation at the University of Mississippi Medical Center. 54 61
19292131 2007
2
GJB2 and GJB6 mutations in children with congenital cytomegalovirus infection. 54 61
17426645 2007
3
Etiology of severe sensorineural hearing loss in children: independent impact of congenital cytomegalovirus infection and GJB2 mutations. 54 61
17299707 2007
4
Cytomegalovirus Seroprevalence and Birth Prevalence of Congenital CMV Infection in Bosnia and Herzegovina: A Single-Center Experience. 61
31738327 2020
5
Prevalence of cytomegalovirus DNAemia and genotypic distribution among childbearing mothers and neonates in Taiwan. 61
31783095 2020
6
Congenital viral infections in England over five decades: a population-based observational study. 61
31708420 2020
7
Massive ascites and severe pulmonary hypoplasia in a premature infant with meconium peritonitis and congenital cytomegalovirus infection. 61
31198083 2020
8
Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec. 61
32031981 2020
9
Do Antivirals Improve Hearing Outcomes in Neonates With Congenital Cytomegalovirus Infection? 61
32010980 2020
10
A Cross-Sectional Study of Caregiver Perceptions of Congenital Cytomegalovirus Infection: Knowledge and Attitudes about Screening. 61
31952844 2020
11
Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study. 61
31927626 2020
12
Cytomegalovirus and Epstein-Barr Virus Associations with Neurological Diseases and the Need for Vaccine Development. 61
31968673 2020
13
Congenital Cytomegalovirus Infection Masquerading as Antenatal Ventriculomegaly With Intraventricular Hemorrhage in a Term Neonate. 61
31839867 2020
14
The MRI spectrum of congenital cytomegalovirus infection. 61
31802515 2020
15
Should You Follow the Better-Hearing Ear for Congenital Cytomegalovirus Infection and Isolated Sensorineural Hearing Loss? 61
31593522 2020
16
Isolated auditory neuropathy at birth in congenital cytomegalovirus infection. 61
31906974 2020
17
Congenital Cytomegalovirus and Autoimmune Neutropenia: Cause or Coincidence? 61
31990888 2020
18
Blood viral load in the diagnostic workup of congenital cytomegalovirus infection. 61
31821950 2020
19
Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection. 61
31575999 2020
20
Birth Prevalence of Congenital Cytomegalovirus Infection in HIV-Exposed Uninfected Children in the Era of Combination Antiretroviral Therapy. 61
31668479 2020
21
Severe Symptomatic Congenital Cytomegalovirus (CMV) Infection Due to Maternal CMV Primary Infection After 20 Weeks of Gestation. 61
31090899 2020
22
Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay. 61
31917817 2020
23
Performance of the Alethia® CMV assay for the detection of cytomegalovirus using neonatal saliva swabs. 61
31969426 2020
24
Middle Ear Effusion in Children With Congenital Cytomegalovirus Infection. 61
31876611 2019
25
Viral Infections and the Neonatal Brain. 61
31813517 2019
26
Growth Patterns in Children With Congenital Cytomegalovirus Infection. 61
31738339 2019
27
Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection. 61
31822287 2019
28
Congenital Infections as Contributors to the Onset of Diabetes in Children: A Longitudinal Study in the United States, 2001-2017. 61
31820549 2019
29
Knowledge of congenital cytomegalovirus (CMV) in pregnant women in Australia is low, and improved with education. 61
31025720 2019
30
Inattention and Hyperactivity in Children with Symptomatic and Asymptomatic Congenital Cytomegalovirus. 61
31714416 2019
31
Clinical factors associated with congenital cytomegalovirus infection: A cohort study of pregnant women and newborns. 61
31789345 2019
32
MVA-Vectored Pentameric Complex (PC) and gB Vaccines Improve Pregnancy Outcome after Guinea Pig CMV Challenge, but Only gB Vaccine Reduces Vertical Transmission. 61
31739399 2019
33
Integration of congenital cytomegalovirus screening within a newborn hearing screening programme. 61
30916438 2019
34
Role of Magnetic Resonance Imaging and Cranial Ultrasonography in Congenital Cytomegalovirus Infection. 61
31626048 2019
35
Isolated Unilateral Cerebellar Hemispheric Dysplasia: A Rare Entity. 61
31352912 2019
36
A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children. 61
31171844 2019
37
Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model. 61
31484753 2019
38
The impact of maternal HIV and malaria infection on the prevalence of congenital cytomegalovirus infection in Western Kenya. 61
31546088 2019
39
Etiology and therapy indication for cochlear implantation in children with single-sided deafness : Retrospective analysis. 61
31478064 2019
40
Prediction of poor neurological development in patients with symptomatic congenital cytomegalovirus diseases after oral valganciclovir treatment. 61
31072632 2019
41
Sequelae of Congenital Cytomegalovirus Following Maternal Primary Infections Are Limited to Those Acquired in the First Trimester of Pregnancy. 61
30596974 2019
42
Saliva Real-Time Polymerase Chain Reaction for Targeted Screening of Congenital Cytomegalovirus Infection. 61
31310307 2019
43
Prevalence of Congenital Cytomegalovirus Infection and Associated Risk of In Utero Human Immunodeficiency Virus (HIV) Acquisition in a High-HIV Prevalence Setting, South Africa. 61
30615106 2019
44
Congenital cytomegalovirus infection registry in flanders: opportunities and pitfalls. 61
31645217 2019
45
Maturation of the immune system in the fetus and the implications for congenital CMV. 61
30981539 2019
46
Impact of Maternal Immunity on Congenital Cytomegalovirus Birth Prevalence and Infant Outcomes: A Systematic Review. 61
31561584 2019
47
Birth prevalence and characteristics of congenital cytomegalovirus infection in an urban birth cohort, Jakarta, Indonesia. 61
31207385 2019
48
Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV. 61
31700667 2019
49
Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV. 61
31700668 2019
50
Congenital human cytomegalovirus infection and neurologic diseases in newborns. 61
31433331 2019

Variations for Congenital Cytomegalovirus

Expression for Congenital Cytomegalovirus

Search GEO for disease gene expression data for Congenital Cytomegalovirus.

Pathways for Congenital Cytomegalovirus

Pathways related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 TNF TLR2 IL1B CCL2
2 12.6 TNF TLR2 IL1B CCL2
3 12.33 TNF TLR2 IL1B CCL2
4
Show member pathways
12.1 TNF TLR2 IL1B
5 12.08 TNF IL1B CCL2
6 12.07 TNF TLR2 IL1B
7
Show member pathways
12.07 TNF TLR2 IL1B CCL2
8
Show member pathways
12.06 TNF TLR2 IL1B
9
Show member pathways
12.02 TNF TLR2 IL1B
10 11.92 TNF IL1B CCL2
11
Show member pathways
11.89 TNF TLR2 IL1B
12 11.87 TNF PPARG IL1B
13
Show member pathways
11.86 TNF TLR2 IL1B
14 11.83 TNF IL1B CCL2
15 11.82 TNF IL1B CCL2
16 11.79 TNF IL1B CCL2
17 11.77 TNF IL1B CCL2
18 11.72 TNF TLR2 IL1B
19 11.7 TNF IL1B CCL2
20 11.59 TNF TLR2 IL1B CCL2
21 11.57 TNF KLRK1 IL1B
22 11.45 TNF IL1B CCL2
23 11.39 TNF TLR2 IL1B
24 11.31 TNF PPARG IL1B CCL2
25 11.27 TNF IL1B CCL2
26 11.12 TNF IL1B
27 10.97 TNF PPARG
28 10.96 TNF IL1B
29 10.94 TLR2 IL1B CCL2
30 10.94 TNF TLR2 IL1B CCL2
31 10.72 TNF TLR2 KLRK1 IL1B CCL2
32 10.64 TNF IL1B CCL2

GO Terms for Congenital Cytomegalovirus

Cellular components related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 connexin complex GO:0005922 8.62 GJB6 GJB2

Biological processes related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 TNF TLR2 IL1B CCL2
2 negative regulation of cell proliferation GO:0008285 9.96 TLR2 PPARG IL1B GJB6
3 inflammatory response GO:0006954 9.92 TNF TLR2 IL1B CCL2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 TNF TLR2 IL1B
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.79 TNF PPARG IL1B
6 defense response to Gram-positive bacterium GO:0050830 9.78 TNF TLR2 KLRK1
7 positive regulation of inflammatory response GO:0050729 9.77 TNF TLR2 IL1B
8 cellular response to organic cyclic compound GO:0071407 9.73 TNF IL1B CCL2
9 cellular response to lipopolysaccharide GO:0071222 9.73 TNF KLRK1 IL1B CCL2
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 TNF TLR2 IL1B
11 positive regulation of interleukin-6 production GO:0032755 9.7 TNF TLR2 IL1B
12 microglial cell activation GO:0001774 9.69 TNF TLR2
13 negative regulation of neurogenesis GO:0050768 9.68 TNF IL1B
14 negative regulation of vascular endothelial cell proliferation GO:1905563 9.68 PPARG CCL2
15 positive regulation of oligodendrocyte differentiation GO:0048714 9.68 TLR2 PPARG
16 regulation of fat cell differentiation GO:0045598 9.67 TNF PPARG
17 positive regulation of chemokine production GO:0032722 9.67 TNF TLR2
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.66 TNF IL1B
19 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL1B
20 negative regulation of lipid catabolic process GO:0050995 9.65 TNF IL1B
21 astrocyte activation GO:0048143 9.65 TNF IL1B
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 TNF KLRK1 IL1B
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 TNF IL1B
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 TNF IL1B
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR2 CCL2
26 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.63 TNF IL1B
27 positive regulation of interferon-gamma production GO:0032729 9.63 TNF KLRK1 IL1B
28 response to lipopolysaccharide GO:0032496 9.62 TLR2 IL1B GJB6 GJB2
29 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL1B
30 positive regulation of chemokine biosynthetic process GO:0045080 9.6 TNF IL1B
31 gap junction assembly GO:0016264 9.58 GJB6 GJB2
32 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
33 cell communication by electrical coupling GO:0010644 9.57 GJB6 GJB2
34 gap junction-mediated intercellular transport GO:1990349 9.55 GJB6 GJB2
35 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
36 sequestering of triglyceride GO:0030730 9.49 TNF IL1B
37 protein kinase B signaling GO:0043491 9.43 TNF IL1B CCL2
38 negative regulation of natural killer cell chemotaxis GO:2000502 9.4 KLRK1 CCL2
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 TNF IL1B
40 positive regulation of interleukin-6 secretion GO:2000778 9.33 TNF TLR2 IL1B
41 positive regulation of interleukin-8 production GO:0032757 9.13 TNF TLR2 IL1B
42 lipopolysaccharide-mediated signaling pathway GO:0031663 8.92 TNF TLR2 IL1B CCL2

Molecular functions related to Congenital Cytomegalovirus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.96 GJB6 GJB2
2 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.62 GJB6 GJB2

Sources for Congenital Cytomegalovirus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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