MCID: CNG578
MIFTS: 21

Congenital Hemangioma

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Fetal diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Congenital Hemangioma

MalaCards integrated aliases for Congenital Hemangioma:

Name: Congenital Hemangioma 58

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

Orphanet 58 ORPHA458775

Summaries for Congenital Hemangioma

MalaCards based summary : Congenital Hemangioma is related to non-involuting congenital hemangioma and rapidly involuting congenital hemangioma. An important gene associated with Congenital Hemangioma is GNAQ (G Protein Subunit Alpha Q). The drugs Ethiodized oil and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver.

Related Diseases for Congenital Hemangioma

Diseases in the Hemangioma family:

Malignant Hemangioma Acquired Hemangioma
Familial Hemangioma Congenital Hemangioma

Diseases related to Congenital Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 non-involuting congenital hemangioma 12.6
2 rapidly involuting congenital hemangioma 12.3
3 partially involuting congenital hemangioma 12.3
4 hemangioma 10.8
5 thrombocytopenia 10.0
6 telangiectasis 10.0
7 teratoma 10.0
8 hemangioendothelioma 10.0
9 pyogenic granuloma 10.0
10 rare vascular tumor 10.0
11 angioma, tufted 9.9
12 fibrosarcoma 9.9
13 congenital fibrosarcoma 9.9
14 kaposiform hemangioendothelioma 9.9
15 posttransplant acute limbic encephalitis 9.9
16 rare tumor 9.9
17 angiosarcoma 9.8
18 hydrocephalus 9.8
19 arteriovenous malformation 9.8
20 vascular cancer 9.8
21 cavernous hemangioma 9.8
22 apnea, obstructive sleep 9.7
23 hemangioma-thrombocytopenia syndrome 9.7
24 melanoma, uveal 9.7
25 myositis 9.7
26 poland syndrome 9.7
27 neural tube defects 9.7
28 chromosome 2q35 duplication syndrome 9.7
29 varicose veins 9.7
30 wilms tumor 1 9.7
31 wilms tumor 5 9.7
32 polydactyly 9.7
33 phace association 9.7
34 rhabdoid tumor predisposition syndrome 1 9.7
35 spondylocostal dysostosis 3, autosomal recessive 9.7
36 deficiency anemia 9.7
37 sleep apnea 9.7
38 suppression amblyopia 9.7
39 amblyopia 9.7
40 heart disease 9.7
41 von willebrand's disease 9.7
42 toxic shock syndrome 9.7
43 mechanical ectropion 9.7
44 ectropion 9.7
45 dysostosis 9.7
46 basal cell carcinoma 9.7
47 lymphangiosarcoma 9.7
48 rhabdomyosarcoma 9.7
49 rhabdoid cancer 9.7
50 protein c deficiency 9.7

Graphical network of the top 20 diseases related to Congenital Hemangioma:



Diseases related to Congenital Hemangioma

Symptoms & Phenotypes for Congenital Hemangioma

Drugs & Therapeutics for Congenital Hemangioma

Drugs for Congenital Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
2
Imiquimod Approved, Investigational Phase 2 99011-02-6 57469
3 Adjuvants, Immunologic Phase 2
4 Immunologic Factors Phase 2
5 Interferon Inducers Phase 2
6 interferons Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. A Phase IV Study. Recruiting NCT02625389 Phase 4 Lipiodol® Ultra Fluid with surgical glues
2 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream

Search NIH Clinical Center for Congenital Hemangioma

Genetic Tests for Congenital Hemangioma

Anatomical Context for Congenital Hemangioma

MalaCards organs/tissues related to Congenital Hemangioma:

40
Heart, Skin, Liver, Tongue, Kidney, Thyroid, Endothelial

Publications for Congenital Hemangioma

Articles related to Congenital Hemangioma:

(show top 50) (show all 161)
# Title Authors PMID Year
1
A case series of Tardive Expansion Congenital Hemangioma: a Variation of NICH or a New Hemangiomatous Entity? 61
32032694 2020
2
Contrast-Enhanced Ultrasound of Congenital and Infantile Hemangiomas: Preliminary Results From a Case Series. 61
31967502 2020
3
Prenatally diagnosed congenital hemangioma with elevated middle cerebral artery peak systolic velocity mimicking the Kasabach-Merritt phenomenon: A case report. 61
31502338 2019
4
Management of a Large Congenital Hemangioma Obstructing Visual Axis: A Case Report and Review of Literature. 61
31593044 2019
5
High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms. 61
31189994 2019
6
Congenital hemangioma of the face-Value of fetal MRI with prenatal ultrasound. 61
31695833 2019
7
Multifocal congenital hemangioma: Expanding the pathogenesis of "neonatal hemangiomatosis". 61
31231857 2019
8
Congenital hemangioma exhibiting postnatal growth. 61
30900306 2019
9
Congenital hemangioma causing heart failure. 61
30255314 2019
10
Microvascular volume visualization utilizing computed tomographic angiography data facilitates resection of a complicated massive congenital hemangioma. 61
30690227 2019
11
Angiographic and Clinical Features of Noninvoluting Congenital Hemangiomas. 61
31023659 2019
12
Compartment Syndrome Secondary to Group A Streptococcus Infection in the Presence of a Congenital Hemangioma. 61
27798538 2019
13
Congenital Large Cutaneous Hemangioma with Arteriovenous and Arterioarterial Malformations: A Novel Association. 61
30661487 2019
14
Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. 61
30422215 2019
15
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring. 61
30244993 2018
16
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. 61
29975248 2018
17
De novo MYH9 mutation in congenital scalp hemangioma. 61
29903892 2018
18
Massive hemorrhage: A rare complication of rapidly involuting congenital hemangioma. 61
29572940 2018
19
Ultrasound findings in rapidly involuting congenital hemangioma (RICH) - beware of venous ectasia and venous lakes. 61
29362838 2018
20
Congenital Hemangioma: A Case Report of a Finding Every Physician Should Know. 61
29922526 2018
21
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma. 61
29561329 2018
22
Rapidly involuting congenital hemangioma. 61
29364450 2017
23
Nasal glial heterotopia or congenital hemangioma? A case report. 61
28391080 2017
24
Congenital capillary proliferation of the kidney: a distinctive renal vascular lesion of childhood. 61
28554576 2017
25
Immunolocalization of substance P and NK-1 receptor in vascular anomalies. 61
27988892 2017
26
Scalp congenital hemangioma with associated high-output cardiac failure in a premature infant: Case report and review of literature. 61
27789620 2017
27
Congenital hemangioma. 61
28207019 2017
28
Rapidly Involuting Congenital Hemangioma of the Hand. 61
28293336 2017
29
[Diagnosis and treatment of the tumors of the parotid region in Pediatrics: cohort]. 61
28481064 2016
30
Prenatal imaging findings of a rapidly involuting congenital hemangioma (RICH) over right flank in a fetus with a favorable outcome. 61
27751430 2016
31
Congenital hemangioma in spondylocostal dysostosis: a novel association. 61
28300884 2016
32
Genetic basis for vascular anomalies. 61
27607321 2016
33
Symptomatic Congenital Hemangioma and Congenital Hemangiomatosis Associated With a Somatic Activating Mutation in GNA11. 61
27438697 2016
34
A rare atypical rapidly involuting congenital hemangioma combined with vascular malformation in the upper limb. 61
27565546 2016
35
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. 61
27259057 2016
36
Surgical removal of a noninvoluting congenital hemangioma using a modified sub-brow flap. 61
27274536 2016
37
Angiogenic Factor with G-patch and FHA Domain 1 (AGGF1) Expression in Human Vascular Lesions. 61
27222614 2016
38
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. 61
27058448 2016
39
[Clinicopathologic study of pediatric vascular anomalies: a report of 117 cases]. 61
27033389 2016
40
Multiple Successful Angioembolizations for Refractory Cardiac Failure in a Preterm with Rapidly Involuting Congenital Hemangioma. 61
26929881 2016
41
[A clinical case of hemangioma of the face and tongue concurrent with severe obstructive sleep apnea syndrome complicated by cardiac arrhythmias and conduction disturbances]. 61
27636935 2016
42
[High frequency electrocoagulation for treating noninvoluting congenital hemangioma]. 61
27055323 2015
43
Unusually Large Patch-Type Noninvoluting Congenital Hemangioma of the Shoulder: A Report of Two Cases. 61
25639275 2015
44
Genitourinary and perineal vascular anomalies in children: A Seattle children's experience. 61
26163459 2015
45
Hepatic Arteriovenous Malformation or Rapidly Involuting Congenital Hemangioma? 61
26413032 2015
46
Imaging evaluation of fetal vascular anomalies. 61
25492302 2015
47
[Clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma in children]. 61
26705041 2015
48
Reticular infantile hemangiomas with minimal or arrested growth associated with lipoatrophy. 61
25766364 2015
49
Rapidly involuting congenital hemangioma with fetal involution. 61
25492638 2015
50
Progressive swelling of the maxilla arising in the radiation site of a congenital hemangioma in a 63-year-old woman. 61
25850869 2015

Variations for Congenital Hemangioma

Expression for Congenital Hemangioma

Search GEO for disease gene expression data for Congenital Hemangioma.

Pathways for Congenital Hemangioma

GO Terms for Congenital Hemangioma

Sources for Congenital Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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