MCID: CNG578
MIFTS: 21

Congenital Hemangioma

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Fetal diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Congenital Hemangioma

MalaCards integrated aliases for Congenital Hemangioma:

Name: Congenital Hemangioma 58

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

Orphanet 58 ORPHA458775

Summaries for Congenital Hemangioma

MalaCards based summary : Congenital Hemangioma is related to non-involuting congenital hemangioma and rapidly involuting congenital hemangioma. An important gene associated with Congenital Hemangioma is GNAQ (G Protein Subunit Alpha Q). The drugs Ethiodized oil and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver.

Related Diseases for Congenital Hemangioma

Diseases in the Hemangioma family:

Malignant Hemangioma Acquired Hemangioma
Familial Hemangioma Congenital Hemangioma

Diseases related to Congenital Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 66, show less)
# Related Disease Score Top Affiliating Genes
1 non-involuting congenital hemangioma 12.6
2 rapidly involuting congenital hemangioma 12.3
3 partially involuting congenital hemangioma 12.3
4 hemangioma 10.8
5 thrombocytopenia 10.0
6 telangiectasis 10.0
7 teratoma 10.0
8 hemangioendothelioma 10.0
9 pyogenic granuloma 10.0
10 rare vascular tumor 10.0
11 angioma, tufted 9.9
12 fibrosarcoma 9.9
13 congenital fibrosarcoma 9.9
14 kaposiform hemangioendothelioma 9.9
15 posttransplant acute limbic encephalitis 9.9
16 rare tumor 9.9
17 angiosarcoma 9.8
18 hydrocephalus 9.8
19 arteriovenous malformation 9.8
20 vascular cancer 9.8
21 cavernous hemangioma 9.8
22 apnea, obstructive sleep 9.7
23 hemangioma-thrombocytopenia syndrome 9.7
24 melanoma, uveal 9.7
25 myositis 9.7
26 poland syndrome 9.7
27 neural tube defects 9.7
28 chromosome 2q35 duplication syndrome 9.7
29 varicose veins 9.7
30 wilms tumor 1 9.7
31 wilms tumor 5 9.7
32 polydactyly 9.7
33 phace association 9.7
34 rhabdoid tumor predisposition syndrome 1 9.7
35 spondylocostal dysostosis 3, autosomal recessive 9.7
36 deficiency anemia 9.7
37 sleep apnea 9.7
38 suppression amblyopia 9.7
39 amblyopia 9.7
40 heart disease 9.7
41 von willebrand's disease 9.7
42 toxic shock syndrome 9.7
43 mechanical ectropion 9.7
44 ectropion 9.7
45 dysostosis 9.7
46 basal cell carcinoma 9.7
47 lymphangiosarcoma 9.7
48 rhabdomyosarcoma 9.7
49 rhabdoid cancer 9.7
50 protein c deficiency 9.7
51 thrombophlebitis 9.7
52 myofibroma 9.7
53 subglottic angioma 9.7
54 epulis 9.7
55 cavernous hemangioma of face 9.7
56 hemolytic anemia 9.7
57 congestive heart failure 9.7
58 compartment syndrome 9.7
59 cleft lip 9.7
60 48,xyyy 9.7
61 encephalocele 9.7
62 sacrococcygeal teratoma 9.7
63 angiomatosis 9.7
64 headache 9.7
65 nasal glial heterotopia 9.7
66 epithelioid hemangioendothelioma 9.7

Graphical network of the top 20 diseases related to Congenital Hemangioma:



Diseases related to Congenital Hemangioma

Symptoms & Phenotypes for Congenital Hemangioma

Drugs & Therapeutics for Congenital Hemangioma

Drugs for Congenital Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 6, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
2
Imiquimod Approved, Investigational Phase 2 99011-02-6 57469
3 Adjuvants, Immunologic Phase 2
4 Immunologic Factors Phase 2
5 Interferon Inducers Phase 2
6 interferons Phase 2

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. A Phase IV Study. Recruiting NCT02625389 Phase 4 Lipiodol® Ultra Fluid with surgical glues
2 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream

Search NIH Clinical Center for Congenital Hemangioma

Genetic Tests for Congenital Hemangioma

Anatomical Context for Congenital Hemangioma

MalaCards organs/tissues related to Congenital Hemangioma:

40
Heart, Skin, Liver, Tongue, Kidney, Thyroid, Endothelial

Publications for Congenital Hemangioma

Articles related to Congenital Hemangioma:

(showing 161, show less)
# Title Authors PMID Year
1
A case series of Tardive Expansion Congenital Hemangioma: a Variation of NICH or a New Hemangiomatous Entity? 61
32032694 2020
2
Contrast-Enhanced Ultrasound of Congenital and Infantile Hemangiomas: Preliminary Results From a Case Series. 61
31967502 2020
3
Prenatally diagnosed congenital hemangioma with elevated middle cerebral artery peak systolic velocity mimicking the Kasabach-Merritt phenomenon: A case report. 61
31502338 2019
4
Management of a Large Congenital Hemangioma Obstructing Visual Axis: A Case Report and Review of Literature. 61
31593044 2019
5
High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms. 61
31189994 2019
6
Congenital hemangioma of the face-Value of fetal MRI with prenatal ultrasound. 61
31695833 2019
7
Multifocal congenital hemangioma: Expanding the pathogenesis of "neonatal hemangiomatosis". 61
31231857 2019
8
Congenital hemangioma exhibiting postnatal growth. 61
30900306 2019
9
Congenital hemangioma causing heart failure. 61
30255314 2019
10
Microvascular volume visualization utilizing computed tomographic angiography data facilitates resection of a complicated massive congenital hemangioma. 61
30690227 2019
11
Angiographic and Clinical Features of Noninvoluting Congenital Hemangiomas. 61
31023659 2019
12
Compartment Syndrome Secondary to Group A Streptococcus Infection in the Presence of a Congenital Hemangioma. 61
27798538 2019
13
Congenital Large Cutaneous Hemangioma with Arteriovenous and Arterioarterial Malformations: A Novel Association. 61
30661487 2019
14
Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. 61
30422215 2019
15
Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring. 61
30244993 2018
16
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. 61
29975248 2018
17
De novo MYH9 mutation in congenital scalp hemangioma. 61
29903892 2018
18
Massive hemorrhage: A rare complication of rapidly involuting congenital hemangioma. 61
29572940 2018
19
Ultrasound findings in rapidly involuting congenital hemangioma (RICH) - beware of venous ectasia and venous lakes. 61
29362838 2018
20
Congenital Hemangioma: A Case Report of a Finding Every Physician Should Know. 61
29922526 2018
21
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma. 61
29561329 2018
22
Rapidly involuting congenital hemangioma. 61
29364450 2017
23
Nasal glial heterotopia or congenital hemangioma? A case report. 61
28391080 2017
24
Congenital capillary proliferation of the kidney: a distinctive renal vascular lesion of childhood. 61
28554576 2017
25
Immunolocalization of substance P and NK-1 receptor in vascular anomalies. 61
27988892 2017
26
Scalp congenital hemangioma with associated high-output cardiac failure in a premature infant: Case report and review of literature. 61
27789620 2017
27
Congenital hemangioma. 61
28207019 2017
28
Rapidly Involuting Congenital Hemangioma of the Hand. 61
28293336 2017
29
[Diagnosis and treatment of the tumors of the parotid region in Pediatrics: cohort]. 61
28481064 2016
30
Prenatal imaging findings of a rapidly involuting congenital hemangioma (RICH) over right flank in a fetus with a favorable outcome. 61
27751430 2016
31
Congenital hemangioma in spondylocostal dysostosis: a novel association. 61
28300884 2016
32
Genetic basis for vascular anomalies. 61
27607321 2016
33
Symptomatic Congenital Hemangioma and Congenital Hemangiomatosis Associated With a Somatic Activating Mutation in GNA11. 61
27438697 2016
34
A rare atypical rapidly involuting congenital hemangioma combined with vascular malformation in the upper limb. 61
27565546 2016
35
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. 61
27259057 2016
36
Surgical removal of a noninvoluting congenital hemangioma using a modified sub-brow flap. 61
27274536 2016
37
Angiogenic Factor with G-patch and FHA Domain 1 (AGGF1) Expression in Human Vascular Lesions. 61
27222614 2016
38
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. 61
27058448 2016
39
[Clinicopathologic study of pediatric vascular anomalies: a report of 117 cases]. 61
27033389 2016
40
Multiple Successful Angioembolizations for Refractory Cardiac Failure in a Preterm with Rapidly Involuting Congenital Hemangioma. 61
26929881 2016
41
[A clinical case of hemangioma of the face and tongue concurrent with severe obstructive sleep apnea syndrome complicated by cardiac arrhythmias and conduction disturbances]. 61
27636935 2016
42
[High frequency electrocoagulation for treating noninvoluting congenital hemangioma]. 61
27055323 2015
43
Unusually Large Patch-Type Noninvoluting Congenital Hemangioma of the Shoulder: A Report of Two Cases. 61
25639275 2015
44
Genitourinary and perineal vascular anomalies in children: A Seattle children's experience. 61
26163459 2015
45
Hepatic Arteriovenous Malformation or Rapidly Involuting Congenital Hemangioma? 61
26413032 2015
46
Imaging evaluation of fetal vascular anomalies. 61
25492302 2015
47
[Clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma in children]. 61
26705041 2015
48
Reticular infantile hemangiomas with minimal or arrested growth associated with lipoatrophy. 61
25766364 2015
49
Rapidly involuting congenital hemangioma with fetal involution. 61
25492638 2015
50
Progressive swelling of the maxilla arising in the radiation site of a congenital hemangioma in a 63-year-old woman. 61
25850869 2015
51
Life-threatening hemorrhaging in neonatal ulcerated congenital hemangioma: two case reports. 61
25565634 2015
52
Successful embolization and long-term follow-up of a rare neonatal diaphragmatic hemangioma. 61
27489702 2015
53
Rapidly involuting congenital hemangioma (RICH): a brief case report. 61
25419759 2014
54
Agminated pyogenic granuloma-like growth arising in a congenital hemangioma. 61
24647574 2014
55
Giant intracranial hemangioma in a neonate. 61
24497024 2014
56
Rapid involuting congenital hemangioma in the setting of PHACE association. 61
24864173 2014
57
Rapidly involuting congenital hemangioma associated with profound, transient thrombocytopenia. 61
22937785 2014
58
Characteristics of noninvoluting congenital hemangioma: a retrospective review. 61
24630000 2014
59
Rapidly involuting congenital hemangioma with pustules: two cases. 61
24689686 2014
60
Expression of follicle-stimulating hormone receptor in vascular anomalies. 61
24572879 2014
61
A 20-day-old boy with a blue skin lesion. Noninvoluting congenital hemangioma. 61
24549083 2014
62
Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. 61
24176519 2014
63
Imaging of vascular tumors with an emphasis on ISSVA classification. 61
24135879 2013
64
Atrophic congenital melanocytic nevus mimicking rapidly involuting congenital hemangioma. 61
22639909 2013
65
Congenital cutaneous hemangioma causing cardiac failure: a case report and review of the literature. 61
23025620 2013
66
Rapidly involuting congenital hemangioma associated with transient anemia and thrombocytopenia. 61
23489172 2013
67
Congenital hemangioma of the skull. 61
24224298 2013
68
Sacrococcygeal teratoma masquerading as congenital hemangioma. 61
22353016 2013
69
Baseline thrombocytopenia complicated by recurrent episodes of transient severe thrombocytopenia following infections in an adult woman with a non involuting congenital hemangioma - a case report. 61
23758712 2013
70
Transjugular retrograde cannulation of the portal vein via patent ductus venosus: alternative access for endovascular hepatic interventions. 61
23273700 2013
71
RICH (rapidly involuting congenital hemangioma): not only a definition of wealth. 61
22497907 2012
72
A prospective study of cutaneous findings in newborns in the United States: correlation with race, ethnicity, and gestational status using updated classification and nomenclature. 61
22497908 2012
73
Capillary hemangioma of palatal mucosa. 61
23162351 2012
74
Rapidly involuting congenital hemangioma. 61
22808633 2012
75
Life-threatening hemorrhage from a congenital hemangioma caused by birth trauma. 61
22595593 2012
76
Postnatal follow-up of rapidly involuting congenital hemangioma (RICH) involving the skull. 61
22262134 2012
77
[Hemangioma. New aspects of pathogenesis, differential diagnosis and therapy]. 61
22349036 2012
78
Right atrial hemangioma in the newborn: Utility of fetal imaging. 61
22529610 2012
79
Vascular anomalies in 5,621 patients: guidelines for referral. 61
21929990 2011
80
Prenatal diagnosis and postnatal follow-up of rapidly involuting congenital hemangioma (RICH). 61
21337126 2011
81
Wilms tumor 1 expression in vascular neoplasms and vascular malformations. 61
21697701 2011
82
Metastatic clear cell renal carcinoma of the palate mimicking noninvoluting congenital hemangioma. 61
21185638 2011
83
[Comparative study on pathology of non involuting congenital hemangioma and infantile hemangioma]. 61
21837995 2011
84
Neonatal rhabdomyosarcoma misdiagnosed as a congenital hemangioma. 61
20738798 2011
85
Novel application of percutaneous cryotherapy for the treatment of recurrent oral bleeding from a noninvoluting congenital hemangioma involving the right buccal space and maxillary tuberosity. 61
20593285 2011
86
Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. 61
21164289 2011
87
Management of hemangiomas and other vascular tumors. 61
21095471 2011
88
[Rapidly involuting congenital hemangioma (RICH) that simulates a minimal cleft lip]. 61
21298927 2010
89
Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report. 61
19247840 2010
90
Rapidly involuting congenital hemangioma: a case of complete prenatal involution. 61
19899150 2010
91
Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy. 61
19588131 2009
92
[Chorioangiomatosis: a rare etiology of nonimmune hydrops fetalis. Obstetric and pediatric implications for patient care]. 61
19699068 2009
93
Intraosseous noninvoluting congenital hemangioma of the mandible in a neonate. 61
20112611 2009
94
[Cervical congenital hemangioma: diagnosis and management difficulties]. 61
19570705 2009
95
MRI characteristics and classification of peripheral vascular malformations and tumors. 61
19020874 2009
96
[Non-involuting congenital hemangioma: a study for diagnosis and treatment]. 61
19803200 2009
97
Prenatal diagnosis of a rapidly involuting congenital hemangioma (RICH) of the skull. 61
19206129 2009
98
Congenital hemangioma: a report of evolution from rapidly involuting to noninvoluting congenital hemangioma with aberrant Mongolian spots. 61
19419482 2009
99
Selective embolization and resection of a large noninvoluting congenital hemangioma of the lower eyelid. 61
19300152 2009
100
[Clinical characteristics and treatment options of cutaneous vessel abnormalities]. 61
19317056 2009
101
Prenatal imaging findings in rapidly involuting congenital hemangioma of the skull. 61
18432598 2008
102
Noninvoluting congenital hemangioma. 61
18627743 2008
103
Rapidly involuting congenital hemangioma: case report and review of the literature. 61
18627733 2008
104
IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma. 61
18287964 2008
105
Congenital fibrosarcoma simulating congenital hemangioma. 61
18304187 2008
106
Multifocal rapidly involuting congenital hemangioma: a link to chorangioma. 61
17937433 2007
107
[Differential expression of CD133, Glut-1 in tissues and endothelial cells derived from infantile hemangioma and vascular malformation]. 61
17926859 2007
108
Huge, alarming congenital hemangioma of the scalp presenting as heart failure and Kasabach-Merritt syndrome: a case report. 61
16937128 2007
109
[Antenatal diagnosis of rapidly involuting congenital hemangiomas (RICH)]. 61
17350057 2007
110
Karyotypic changes detected by comparative genomic hybridization in a stillborn infant with chorioangioma and liver hemangioma. 61
17203486 2007
111
[Prenatal diagnosis and management of a case of rapidly involuting congenital hemangioma. Review of literature]. 61
16940909 2006
112
Poland syndrome (anomaly) with congenital hemangioma: a new association. 61
16766839 2006
113
[Congenital hemangioma arising of internal orbitary edge. Importance of ENT exploration and treatment options]. 61
16566199 2006
114
Acute compartment syndrome of the foot caused by a hemangioma. 61
16399561 2006
115
D2-40 immunohistochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma. 61
15920541 2005
116
Giant rapidly involuting congenital hemangioma of the face: 15-year follow-up. 61
16172340 2005
117
[The impact of Glut-1 marker application on the diagnosis and treatment of congenital vascular anomalies]. 61
16209371 2005
118
[Diagnosis and treatment of congenital hemangioma and vascular malformation]. 61
15938877 2005
119
Congenital hemangiomas and infantile hemangioma: missing links. 61
15153887 2004
120
Rapidly involuting congenital hemangioma: clinical and histopathologic features. 61
15018449 2003
121
Primary angiosarcoma of the parotid gland arising from benign congenital hemangioma. 61
12847446 2003
122
Angiographic features of rapidly involuting congenital hemangioma (RICH). 61
12497230 2003
123
[Noninvoluting congenital hemangioma: 2 cases]. 61
12124519 2002
124
Sonographic findings in a series of rapidly involuting congenital hemangiomas (RICH). 61
11860561 2002
125
Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. 61
11391180 2001
126
An unusual subdural empyema: case report. 61
11045022 2000
127
Images in clinical medicine. Congenital hemangioma. 61
10194238 1999
128
Oral giant pyogenic granulomas associated with facial skin hemangiomas (Sturge-Weber syndrome). 61
10860035 1999
129
Congenital hemangioma with milialike structures: a case report. 61
9720700 1998
130
[A case of congenital hemangioma of the left lower extremity]. 61
9549297 1997
131
Angiodysplasia: new look at an old conundrum. 61
25989720 1997
132
Congenital hemangioma: evidence of accelerated involution. 61
8774499 1996
133
Cutaneous angiosarcoma arising in the radiation site of a congenital hemangioma. 61
7593798 1995
134
Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. 61
8523253 1995
135
Advanced practice case study: congenital hemangiomas. 61
7780418 1995
136
Basal cell carcinoma presenting as a delayed complication of thorium X used for treating a congenital hemangioma. 61
7929926 1994
137
[Intracranial pressure in sleep apnea, hydrocephalus and congenital hemangioma. A case report]. 61
8053280 1994
138
Congenital hemangioma of eccrine sweat glands. 61
8302736 1993
139
Development of Kasabach-Merritt syndrome following needle aspiration of a hemangioma. 61
1513734 1992
140
The development during pregnancy of pyogenic granulomas superimposed upon a congenital hemangioma: a case report. 61
2778604 1989
141
Pulmonary thromboembolism from a large hemangioma in a 4-week-old infant. 61
2717500 1989
142
Presentation and management of postcricoid hemangiomata in infancy. 61
3600138 1987
143
Late complication of congenital hemangioma of the tongue. 61
3623953 1987
144
Thyroid nodules in children. 61
3106898 1986
145
Hyperfibrinogenemia with ulcerations overlying a congenital hemangioma. A clue to Hodgkin's disease. 61
4066103 1985
146
Congenital laryngeal hemangioma. 61
6625442 1983
147
Tumor Conference #48. Massive congenital hemangioma resulting in death. 61
6853818 1983
148
Coarctation of the aorta with congenital hemangioma of the face and neck and aneurysm or dilatation of a subclavian or innominate artery. A new syndrome? 61
7047095 1982
149
Predicting the course of a congenital hemangioma. 61
419194 1979
150
Carbon dioxide laser treatment of dermatologic lesions. 61
663725 1978
151
Congenital hemangioma of the orbit and lid. 61
4817486 1974
152
[Hemangioma of the nasal and Highmore area in conjunction with congenital hemangioma of the facial skin]. 61
5620815 1967
153
Ordinary varicose veins as an expression of congenital hemangioma. 61
5941846 1966
154
[A case of congenital hemangioma of the orbit]. 61
6010653 1966
155
CONGENITAL HEMANGIOMA. 61
14173057 1964
156
[CONGENITAL HEMANGIOMA OF THE LARYNX]. 61
14181345 1964
157
Congenital hemangioma of the parotid gland. 61
14007983 1962
158
Congenital hemangioma with thrombocytopenia. 61
13789290 1961
159
Congenital hemangioma of the larynx. 61
13333169 1956
160
Congenital hemangioma of the larynx. 61
13422520 1956
161
Treatment of congenital hemangioma. 61
20990134 1946

Variations for Congenital Hemangioma

Expression for Congenital Hemangioma

Search GEO for disease gene expression data for Congenital Hemangioma.

Pathways for Congenital Hemangioma

GO Terms for Congenital Hemangioma

Sources for Congenital Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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