MCID: CNG100
MIFTS: 17

Congenital Herpes Simplex

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Congenital Herpes Simplex

MalaCards integrated aliases for Congenital Herpes Simplex:

Name: Congenital Herpes Simplex 54 74

Classifications:



External Ids:

UMLS 74 C0276225

Summaries for Congenital Herpes Simplex

MalaCards based summary : Congenital Herpes Simplex is related to congenital herpes simplex virus infection and neonatal herpes. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone.

Related Diseases for Congenital Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Congenital Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 congenital herpes simplex virus infection 12.5
2 neonatal herpes 11.3
3 herpes simplex 10.5
4 endophthalmitis 10.0
5 hydrocephalus, congenital, 1 9.9
6 cataract 9.9
7 epidermolysis bullosa 9.9
8 retinitis 9.9
9 myocarditis 9.9
10 giant cell myocarditis 9.9
11 congenital erosive and vesicular dermatosis 9.9

Graphical network of the top 20 diseases related to Congenital Herpes Simplex:



Diseases related to Congenital Herpes Simplex

Symptoms & Phenotypes for Congenital Herpes Simplex

Drugs & Therapeutics for Congenital Herpes Simplex

Drugs for Congenital Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 3,Phase 1,Phase 2 59277-89-3 2022
2 Anti-Infective Agents Phase 3,Phase 1,Phase 2
3 Antiviral Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
2 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
3 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
4 Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection Completed NCT00004644 Phase 1, Phase 2 acyclovir
5 A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) Withdrawn NCT01610765 Phase 1, Phase 2 Novel Antiviral Drug;Placebo

Search NIH Clinical Center for Congenital Herpes Simplex

Genetic Tests for Congenital Herpes Simplex

Anatomical Context for Congenital Herpes Simplex

MalaCards organs/tissues related to Congenital Herpes Simplex:

42
Skin, Eye, Bone

Publications for Congenital Herpes Simplex

Articles related to Congenital Herpes Simplex:

(show all 18)
# Title Authors Year
1
Congenital Herpes Simplex Virus Type 1 Infection Mimicking Congenital Erosive and Vesicular Dermatosis: Possible Pathogenic Insights. ( 28543846 )
2017
2
Congenital Herpes Simplex Virus in the Newborn: A Diagnostic Dilemma. ( 27021037 )
2016
3
Severe congenital herpes simplex virus infection. ( 23925704 )
2014
4
Unusual concurrence of heterotopic glial nodule of the scalp and congenital herpes simplex virus type-2 infection. ( 23998268 )
2013
5
A rare case of absent corpus callosum with severe ventriculomegaly due to congenital herpes simplex infection. ( 20373944 )
2010
6
Congenital herpes simplex virus infection: two unique cutaneous presentations associated with probable intrauterine transmission. ( 19150274 )
2009
7
Non-immune hydrops associated with congenital herpes simplex infection. ( 8235566 )
1993
8
Normal development after congenital herpes simplex virus infection? ( 2062613 )
1991
9
How rare is congenital herpes simplex? A literature review. ( 2661816 )
1989
10
Giant-cell myocarditis in a newborn with congenital herpes simplex virus (HSV) infection: an immunohistochemical study on the origin of the giant cells. ( 3295830 )
1986
11
Congenital herpes simplex retinitis. ( 3728622 )
1986
12
Congenital herpes simplex type II infection. ( 2992275 )
1985
13
Congenital herpes simplex virus infection diagnosed by cytology of aspirated tracheobronchial material. ( 2996272 )
1985
14
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. ( 6985228 )
1982
15
Congenital herpes simplex virus infection initially resembling epidermolysis bullosa. ( 7143173 )
1982
16
Congenital herpes simplex virus infections. Report of three cases and review of the literature. ( 507886 )
1979
17
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. ( 206999 )
1977
18
Congenital herpes simplex type II infection with extensive hepatic calcification, bone lesions and cataracts: complete postmortem examination. ( 892252 )
1977

Variations for Congenital Herpes Simplex

Expression for Congenital Herpes Simplex

Search GEO for disease gene expression data for Congenital Herpes Simplex.

Pathways for Congenital Herpes Simplex

GO Terms for Congenital Herpes Simplex

Sources for Congenital Herpes Simplex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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