MCID: CNG100
MIFTS: 23

Congenital Herpes Simplex

Categories: Fetal diseases, Infectious diseases, Oral diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Congenital Herpes Simplex

MalaCards integrated aliases for Congenital Herpes Simplex:

Name: Congenital Herpes Simplex 52 71
Mother-to-Child Transmission of Herpes Simplex Virus Infection 52 58
Congenital Herpes Simplex Virus Infection 52 58
Antenatal Herpes Simplex Virus Infection 52 58

Characteristics:

Orphanet epidemiological data:

58
congenital herpes simplex virus infection
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal;

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis
Teratologic disorders
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 P35.2
Orphanet 58 ORPHA293
UMLS 71 C0276225

Summaries for Congenital Herpes Simplex

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 293 Definition Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent foetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs , such as the liver or central nervous system , are less frequent. Clinical description Skin lesions and scars, chorioretinitis, microcephaly , hydrencephaly, and microphthalmia have been described in infants with in utero primary herpes virus infections, but a causal relationship between these manifestations and the infection could not be established. Pregnancy complications including preterm delivery, intrauterine growth retardation, and neonatal infection have been attributed to the herpes virus. Etiology There are two types of virus (HSV-1 and HSV-2) and both appear to have the same activity. However, type 1 infections more commonly involve the oral cavity, whereas type 2 infections more commonly involve the genital region. It has been suggested that latent HSV-2 infections occur in as many as 20 to 40% of women. Exposure of the foetus to herpes virus at the time of delivery carries a serious risk of infection for the newborn. This risk may be high during the initial infection of the mother (33 to 50%), but probably does not exceed 3% in cases of reinfection because of the protective effect of maternal antibodies . Differential diagnosis It remains difficult to distinguish between cases with a primary infection and those with a previously undetected recurrent infection that has become symptomatic during pregnancy. Management and treatment In spite of described cases of serious foetal illness, primary infection with herpes virus during pregnancy is not an indication for therapeutic abortion, and the use of antivirals in the treatment of primary herpes infections during gestation has been recommended. Some authors recommend caesarean delivery for women with first-episode genital herpes lesions at the time of delivery. Visit the Orphanet disease page for more resources.

MalaCards based summary : Congenital Herpes Simplex, also known as mother-to-child transmission of herpes simplex virus infection, is related to neonatal herpes and herpes simplex. Affiliated tissues include skin, liver and bone, and related phenotypes are intrauterine growth retardation and premature birth

Related Diseases for Congenital Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Congenital Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 23, show less)
# Related Disease Score Top Affiliating Genes
1 neonatal herpes 11.4
2 herpes simplex 10.5
3 herpes virus antenatal infection 10.2
4 neuroretinitis 10.1
5 retinitis 10.1
6 vaginitis 10.0
7 endophthalmitis 10.0
8 keratoconjunctivitis 10.0
9 herpes simplex encephalitis 10.0
10 keratitis, hereditary 9.9
11 sarcoidosis 1 9.9
12 hydrocephalus, congenital, 1 9.9
13 hydrops fetalis, nonimmune 9.9
14 microphthalmia 9.9
15 microcephaly 9.9
16 epidermolysis bullosa 9.9
17 myocarditis 9.9
18 cataract 9.9
19 chorioretinitis 9.9
20 encephalitis 9.9
21 giant cell myocarditis 9.9
22 congenital erosive and vesicular dermatosis 9.9
23 immune hydrops fetalis 9.9

Graphical network of the top 20 diseases related to Congenital Herpes Simplex:



Diseases related to Congenital Herpes Simplex

Symptoms & Phenotypes for Congenital Herpes Simplex

Human phenotypes related to Congenital Herpes Simplex:

58 31 (showing 4, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 58 31 frequent (33%) Frequent (79-30%) HP:0001511
2 premature birth 58 31 frequent (33%) Frequent (79-30%) HP:0001622
3 microcephaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0000252
4 hydranencephaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002324

Drugs & Therapeutics for Congenital Herpes Simplex

Search Clinical Trials , NIH Clinical Center for Congenital Herpes Simplex

Genetic Tests for Congenital Herpes Simplex

Anatomical Context for Congenital Herpes Simplex

MalaCards organs/tissues related to Congenital Herpes Simplex:

40
Skin, Liver, Bone

Publications for Congenital Herpes Simplex

Articles related to Congenital Herpes Simplex:

(showing 32, show less)
# Title Authors PMID Year
1
Widespread aplasia cutis due to congenital herpes simplex virus. 61
32020645 2020
2
A case of congenital herpes simplex virus infection diagnosed at 8 months of age. 61
32001045 2020
3
Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review. 61
31663621 2019
4
Congenital Herpes Simplex Virus Type 1 Infection Mimicking Congenital Erosive and Vesicular Dermatosis: Possible Pathogenic Insights. 61
28543846 2017
5
Congenital Herpes Simplex Virus in the Newborn: A Diagnostic Dilemma. 61
27021037 2016
6
A rare infectious cause of severe neonatal skin lesions. 61
26452409 2015
7
Severe congenital herpes simplex virus infection. 61
23925704 2014
8
Unusual concurrence of heterotopic glial nodule of the scalp and congenital herpes simplex virus type-2 infection. 61
23998268 2013
9
A rare case of absent corpus callosum with severe ventriculomegaly due to congenital herpes simplex infection. 61
20373944 2010
10
Hybrid notes: incisionless intragastric stapled cystgastrostomy of a pancreatic pseudocyst. 61
20105584 2010
11
Congenital herpes simplex virus infection: two unique cutaneous presentations associated with probable intrauterine transmission. 61
19150274 2009
12
Bilateral macular scars following intrauterine herpes simplex virus type 2 infection. 61
18440255 2008
13
Incontinentia pigmenti mimicking a herpes simplex virus infection in the newborn. 61
17632728 2008
14
Herpes simplex virus colitis in a neonate. 61
12380594 2002
15
Self-healing congenital Langerhans cell histiocytosis presenting as neonatal papulovesicular eruption. 61
11907857 2001
16
TORCH syndrome. 61
7640200 1995
17
The role of cytomegalovirus (CMV) infection in congenital diseases in Malaysia. 61
8090088 1994
18
Non-immune hydrops associated with congenital herpes simplex infection. 61
8235566 1993
19
Normal development after congenital herpes simplex virus infection? 61
2062613 1991
20
How rare is congenital herpes simplex? A literature review. 61
2661816 1989
21
Congenital infection with herpes simplex virus type 1. 61
3444785 1987
22
Congenital disseminated herpes simplex virus type II infection in a premature infant. 61
3651193 1987
23
Congenital herpes simplex retinitis. 61
3728622 1986
24
Giant-cell myocarditis in a newborn with congenital herpes simplex virus (HSV) infection: an immunohistochemical study on the origin of the giant cells. 61
3295830 1986
25
Congenital herpes simplex virus infection diagnosed by cytology of aspirated tracheobronchial material. 61
2996272 1985
26
Congenital herpes simplex type II infection. 61
2992275 1985
27
Congenital herpes simplex virus infection initially resembling epidermolysis bullosa. 61
7143173 1982
28
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. 61
6985228 1982
29
Congenital herpes simplex virus infections. Report of three cases and review of the literature. 61
507886 1979
30
Computed tomography in the evaluation of herpes simplex encephalitis. 61
897158 1977
31
Congenital herpes simplex type II infection with extensive hepatic calcification, bone lesions and cataracts: complete postmortem examination. 61
892252 1977
32
Congenital herpes simplex virus, type 2, bilateral endophthalmitis. 61
206999 1977

Variations for Congenital Herpes Simplex

Expression for Congenital Herpes Simplex

Search GEO for disease gene expression data for Congenital Herpes Simplex.

Pathways for Congenital Herpes Simplex

GO Terms for Congenital Herpes Simplex

Sources for Congenital Herpes Simplex

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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19 FMA
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30 HMDB
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32 ICD10
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44 MESH via Orphanet
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50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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