MCID: CNG489
MIFTS: 26

Congenital Herpes Simplex Virus Infection

Categories: Fetal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Congenital Herpes Simplex Virus Infection

MalaCards integrated aliases for Congenital Herpes Simplex Virus Infection:

Name: Congenital Herpes Simplex Virus Infection 59
Mother-to-Child Transmission of Herpes Simplex Virus Infection 59
Antenatal Herpes Simplex Virus Infection 59
Congenital Herpes Simplex 72
Neonatal Herpes 72

Characteristics:

Orphanet epidemiological data:

59
congenital herpes simplex virus infection
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal;

Classifications:



External Ids:

ICD10 via Orphanet 34 P35.2
Orphanet 59 ORPHA293
UMLS 72 C0276225 C2931185

Summaries for Congenital Herpes Simplex Virus Infection

MalaCards based summary : Congenital Herpes Simplex Virus Infection, also known as mother-to-child transmission of herpes simplex virus infection, is related to herpes simplex and congenital herpes simplex. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are intrauterine growth retardation and premature birth

Related Diseases for Congenital Herpes Simplex Virus Infection

Diseases related to Congenital Herpes Simplex Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 herpes simplex 10.4
2 congenital herpes simplex 10.4
3 epidermolysis bullosa 10.0

Symptoms & Phenotypes for Congenital Herpes Simplex Virus Infection

Human phenotypes related to Congenital Herpes Simplex Virus Infection:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 59 32 frequent (33%) Frequent (79-30%) HP:0001511
2 premature birth 59 32 frequent (33%) Frequent (79-30%) HP:0001622
3 microcephaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0000252
4 hydranencephaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0002324

Drugs & Therapeutics for Congenital Herpes Simplex Virus Infection

Drugs for Congenital Herpes Simplex Virus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 3 59277-89-3 2022
2 Anti-Infective Agents Phase 3
3 Antiviral Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Placebo-Controlled Phase III Evaluation of Suppressive Therapy With Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Limited to the Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
2 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
3 A Placebo-Controlled Phase III Evaluation of Suppressive Therapy With Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Involving the Central Nervous System Completed NCT00031460 Phase 3 Acyclovir;Placebo
4 Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection Completed NCT00004644 Phase 1, Phase 2 acyclovir
5 A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) Withdrawn NCT01610765 Phase 1, Phase 2 Novel Antiviral Drug;Placebo
6 An Open Label Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants Completed NCT00942084 Phase 1 Acyclovir
7 HSV Seroprevalence and Diagnosis of Genital Herpes in Pregnant Women Completed NCT00291044

Search NIH Clinical Center for Congenital Herpes Simplex Virus Infection

Genetic Tests for Congenital Herpes Simplex Virus Infection

Anatomical Context for Congenital Herpes Simplex Virus Infection

MalaCards organs/tissues related to Congenital Herpes Simplex Virus Infection:

41
Skin, Eye, Testes, Liver, Brain, Breast, Bone Marrow

Publications for Congenital Herpes Simplex Virus Infection

Articles related to Congenital Herpes Simplex Virus Infection:

(show top 50) (show all 665)
# Title Authors PMID Year
1
Using Quality Improvement to Implement a Standardized Approach to Neonatal Herpes Simplex Virus. 38
31345997 2019
2
Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis. 38
31112493 2019
3
Mortality from neonatal herpes simplex viremia causing severe hepatitis. 38
31347030 2019
4
Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections: To Treat or Not to Treat? 38
31205247 2019
5
Congenital neonatal herpes simplex retinitis. 38
31109490 2019
6
Laboratory Diagnosis of Neonatal Herpes Simplex Virus Infections. 38
30602444 2019
7
Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. 38
30911082 2019
8
Tools for the Diagnosis of Herpes Simplex Virus 1/2: Systematic Review of Studies Published Between 2012 and 2018. 38
31124465 2019
9
Disseminated neonatal herpes simplex virus infection: Postnatal acquisition and familial spread during migration to Germany. 38
30639782 2019
10
Neonatal Herpes Simplex Virus Infection Among Medicaid-Enrolled Children: 2009-2015. 38
30923058 2019
11
Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. 38
30971454 2019
12
Neonatal Herpes Simplex Virus Infections: New Data, Old Conundrum. 38
30923057 2019
13
Maintaining Breastfeeding During Severe Infant and Maternal HSV-1 Infection: A Case Report. 38
30840531 2019
14
Critically Severe Case of Neonatal Herpes with High Viral Load and Hemophagocytic Syndrome. 38
30828029 2019
15
Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey. 38
30831604 2019
16
Incidence and Characteristics of Neonatal Herpes: Comparison of Two Population-Based Data Sources, New York City, 2006-2015. 38
30640862 2019
17
[Diagnostic and therapeutic recommendations for sexually transmitted diseases: Genital herpes]. 38
30366717 2019
18
Problematic molecular diagnosis of HSV-1 infection due to a single nucleotide polymorphism in the US7 gene. 38
30530285 2019
19
Seroprevalence of Herpes Simplex Virus Types 1 and 2 Among Pregnant Women and Sexually Active, Nonpregnant Women in the United States. 38
29668856 2018
20
Sixty seconds on . . . neonatal herpes. 38
30209054 2018
21
Should Caesarian Section Be Offered to Women With Recurrent Genital Herpes Simplex Lesions After >4 Hours of Ruptured Membranes? 38
30103879 2018
22
Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? 38
29356762 2018
23
[The Spanish Society of Paediatric Infectious Diseases guidelines on the prevention, diagnosis and treatment of neonatal herpes simplex infections]. 38
29453157 2018
24
Vertical transmission of herpes simplex virus: an update. 38
29762896 2018
25
Disseminated Neonatal Herpes Simplex Virus Infection with Escherichia Coli Coinfection. 38
28678413 2018
26
Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). 38
29571124 2018
27
Neonatal herpes simplex virus infections. 38
29544668 2018
28
[Erratum to "Neonatal herpes: Epidemiology, clinical manifestations and management. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)" [Gynecol Obstet Fertil Senol 45 (2017) 691-704]]. 38
29530561 2018
29
Premature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis. 38
29174006 2018
30
Herpes Simplex Virus Infection in Infants Undergoing Meningitis Evaluation. 38
29298827 2018
31
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. 38
27849421 2018
32
Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection. 38
30009071 2018
33
Meeting report: Initial World Health Organization consultation on herpes simplex virus (HSV) vaccine preferred product characteristics, March 2017. 38
29224963 2017
34
[Neonatal herpes: Epidemiology, clinical manifestations and management. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)]. 38
29132771 2017
35
[Genital herpes and pregnancy: Serological and molecular diagnostic tools. Guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF)]. 38
29132769 2017
36
[Management of pregnant women with recurrent herpes. Guidelines for clinical practice from the French College of Gynecologists, Obstetricians (CNGOF)]. 38
29132770 2017
37
Antiviral Drugs in Newborn and Children. 38
29173793 2017
38
Pathogenesis of Non-Zika Congenital Viral Infections. 38
29267912 2017
39
Preventing neonatal herpes infections through maternal immunization. 38
29339967 2017
40
Delayed Recurrence of Herpes Simplex Virus Infection in the Central Nervous System After Neonatal Infection and Completion of Six Months of Suppressive Therapy. 38
28379476 2017
41
Pregnancy Outcomes in Association with STDs including genital HSV-2 shedding in a South African Cohort Study. 38
28396556 2017
42
Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1. 38
28701403 2017
43
Biologic interactions between HSV-2 and HIV-1 and possible implications for HSV vaccine development. 38
28958807 2017
44
Disseminated Neonatal Herpes Simplex Virus Type 1 After a Water Birth. 38
28510692 2017
45
Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control. 38
28683784 2017
46
Persistent Gaps in Appropriate Use of Empiric Acyclovir in Neonates. 38
27941084 2017
47
[Update on congenital and neonatal herpes infections: infection due to cytomegalovirus and herpes simplex]. 38
28524216 2017
48
[How I treat… a neonatal Herpes simplex virus infection]. 38
28520319 2017
49
Safety of High-dose Acyclovir in Infants With Suspected and Confirmed Neonatal Herpes Simplex Virus Infections. 38
27977557 2017
50
Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure. 38
28392553 2017

Variations for Congenital Herpes Simplex Virus Infection

Expression for Congenital Herpes Simplex Virus Infection

Search GEO for disease gene expression data for Congenital Herpes Simplex Virus Infection.

Pathways for Congenital Herpes Simplex Virus Infection

GO Terms for Congenital Herpes Simplex Virus Infection

Sources for Congenital Herpes Simplex Virus Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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