MCID: CNG439
MIFTS: 32

Congenital Lymphedema

Categories: Cardiovascular diseases, Fetal diseases, Genetic diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Congenital Lymphedema

MalaCards integrated aliases for Congenital Lymphedema:

Name: Congenital Lymphedema 52 54
Milroy Disease 71

Classifications:



External Ids:

UMLS 71 C1704423

Summaries for Congenital Lymphedema

MalaCards based summary : Congenital Lymphedema, also known as milroy disease, is related to lymphatic malformation 1 and angiosarcoma. An important gene associated with Congenital Lymphedema is FLT4 (Fms Related Receptor Tyrosine Kinase 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Pathways in cancer. Affiliated tissues include breast, endothelial and skin, and related phenotypes are immune system and mortality/aging

Related Diseases for Congenital Lymphedema

Diseases in the Primary Lymphedema family:

Hereditary Lymphedema Hereditary Lymphedema Ic
Hereditary Lymphedema Id Hereditary Lymphedema Ia
Hereditary Lymphedema Ib Hereditary Lymphedema I
Hereditary Lymphedema Ii Congenital Lymphedema
Celsr1-Related Late-Onset Primary Lymphedema Gjc2-Related Late-Onset Primary Lymphedema

Diseases related to Congenital Lymphedema via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 82, show less)
# Related Disease Score Top Affiliating Genes
1 lymphatic malformation 1 32.7 VEGFC FLT4
2 angiosarcoma 30.2 PDPN FLT4
3 hereditary lymphedema i 30.1 VEGFC PDPN FOXC2 FLT4
4 klippel-trenaunay-weber syndrome 29.7 FOXC2 FLT4
5 lymphangiosarcoma 29.6 VEGFC PDPN FLT4
6 hennekam syndrome 29.3 VEGFC FOXC2 FLT4
7 lymphangioma 29.3 VEGFC PDPN FLT4
8 hereditary lymphedema 29.2 VEGFC HNRNPH1 FOXC2 FLT4
9 lymphedema-distichiasis syndrome 29.1 VEGFC FOXC2 FLT4
10 primary lymphedema 29.0 VEGFD VEGFC FOXC2 FLT4
11 lymphangitis 28.2 VEGFD VEGFC PDPN FLT4
12 agenesis of the corpus callosum and congenital lymphedema 12.4
13 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 11.7
14 lymphedema-hypoparathyroidism syndrome 11.6
15 hennekam lymphangiectasia-lymphedema syndrome 1 11.1
16 tuberous sclerosis 10.1
17 lymphangiectasis 10.1
18 distichiasis 10.1
19 microcephaly 10.1
20 orbital lymphangioma 10.0 PDPN FLT4
21 hobnail hemangioma 10.0 PDPN FLT4
22 hereditary lymphedema ii 10.0 FOXC2 FLT4
23 capillary lymphangioma 10.0 PDPN FLT4
24 capillary hemangioma 10.0 PDPN FLT4
25 cardiovascular cancer 10.0 PDPN FLT4
26 hydrops fetalis, nonimmune 9.9
27 erysipelas 9.9
28 squamous cell carcinoma 9.9
29 cellulitis 9.9
30 elephantiasis 9.9
31 vascular cancer 9.9 PDPN FLT4
32 cystic lymphangioma 9.9 PDPN FOXC2
33 mucinous cystadenocarcinoma of the pancreas 9.9 VEGFC PDPN
34 cystadenocarcinoma 9.9 VEGFC PDPN
35 filariasis 9.9 FOXC2 FLT4
36 cardiovascular organ benign neoplasm 9.9 PDPN FLT4
37 corneal neovascularization 9.8 VEGFC FLT4
38 microinvasive gastric cancer 9.8 VEGFC PDPN
39 coarctation of aorta 9.8
40 hirschsprung disease 1 9.8
41 spondyloepiphyseal dysplasia with congenital joint dislocations 9.8
42 kaposi sarcoma 9.8
43 tuberous sclerosis 1 9.8
44 ascites, chylous 9.8
45 lissencephaly 2 9.8
46 opitz-kaveggia syndrome 9.8
47 branchiootic syndrome 1 9.8
48 hypertrophic scars 9.8
49 walker-warburg syndrome 9.8
50 rheumatic heart disease 9.8
51 cerebellar hypoplasia 9.8
52 endocarditis 9.8
53 protein-losing enteropathy 9.8
54 hypoparathyroidism 9.8
55 hemopericardium 9.8
56 cardiac tamponade 9.8
57 pericardial effusion 9.8
58 oligohydramnios 9.8
59 ichthyosis 9.8
60 basal cell carcinoma 9.8
61 bilirubin metabolic disorder 9.8
62 purpura 9.8
63 palmoplantar keratosis 9.8
64 turner syndrome 9.8
65 angiokeratoma 9.8
66 bronchitis 9.8
67 polyhydramnios 9.8
68 fasciitis 9.8
69 necrotizing fasciitis 9.8
70 nonsyndromic deafness 9.8
71 rare lymphatic malformation 9.8
72 hereditary palmoplantar keratoderma 9.8
73 breast carcinoma in situ 9.7 VEGFC FLT4
74 twin-to-twin transfusion syndrome 9.6 VEGFD VEGFC
75 kuhnt-junius degeneration 9.6 VEGFD VEGFC
76 gorham's disease 9.6 VEGFC PDPN FLT4
77 lymphangioleiomyomatosis 9.3 VEGFD VEGFC PDPN
78 kidney cancer 9.2 VEGFD VEGFC FLT4
79 macular degeneration, age-related, 1 9.1 VEGFD VEGFC FLT4
80 pancreatic adenocarcinoma 9.0 VEGFD VEGFC FLT4
81 chylothorax, congenital 9.0 VEGFD VEGFC FOXC2 FLT4
82 gastric adenocarcinoma 8.9 VEGFD VEGFC FLT4

Graphical network of the top 20 diseases related to Congenital Lymphedema:



Diseases related to Congenital Lymphedema

Symptoms & Phenotypes for Congenital Lymphedema

MGI Mouse Phenotypes related to Congenital Lymphedema:

45 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.43 FLT4 FOXC2 HNRNPH1 PDPN VEGFC VEGFD
2 mortality/aging MP:0010768 9.17 FLT4 FOXC2 HNRNPH1 KIF11 PDPN VEGFC

Drugs & Therapeutics for Congenital Lymphedema

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment Unknown status NCT01273909

Search NIH Clinical Center for Congenital Lymphedema

Genetic Tests for Congenital Lymphedema

Anatomical Context for Congenital Lymphedema

MalaCards organs/tissues related to Congenital Lymphedema:

40
Breast, Endothelial, Skin, Lymph Node, Bone, Brain, Spinal Cord

Publications for Congenital Lymphedema

Articles related to Congenital Lymphedema:

(showing 256, show less)
# Title Authors PMID Year
1
Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas. 54 61
19002718 2009
2
A novel VEGFR3 mutation causes Milroy disease. 61 54
17458866 2007
3
Hereditary lymphedema type I associated with VEGFR3 mutation: the first de novo case and atypical presentations. 54 61
16965327 2006
4
Wide clinical spectrum in a family with hereditary lymphedema type I due to a novel missense mutation in VEGFR3. 54 61
16924388 2006
5
Clinical variability in a Japanese hereditary lymphedema type I family with an FLT4 mutation. 61 54
15904433 2005
6
Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. 61 54
15743802 2005
7
Milroy disease and the VEGFR-3 mutation phenotype. 54 61
15689446 2005
8
Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. 54 61
12740761 2003
9
Congenital lymphedema as a rare and first symptom of tuberous sclerosis complex. 61
32479982 2020
10
A Case of Congenital Lymphedema Complicated by Chronic Chylous Effusions and Recurrent Pericardial Effusion Requiring Pericardial Window. 61
32550076 2020
11
Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome. 61
31633297 2020
12
Surgical treatment of Milroy disease. 61
31165487 2020
13
Lymphoscintigraphic Abnormalities Associated with Milroy Disease and Lymphedema-Distichiasis Syndrome. 61
31721633 2019
14
Congenital lymphangioma circumscriptum of the vulva. 61
31364200 2019
15
Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot. 61
30582441 2019
16
Immunohistochemical Evaluation of Histological Change in a Chinese Milroy Disease Family With Venous and Skin Abnormities. 61
30941160 2019
17
A Novel Mutation of KIF11 in a Child with 22q11.2 Deletion Syndrome Associated with MCLMR. 61
30733662 2019
18
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation. 61
30482854 2018
19
Angiosarcoma arising from congenital primary lymphedema. 61
30216524 2018
20
Unilateral Primary Congenital Lymphedema of the Upper Limb in an 11-Month-Old Infant: A Clinical and Pharmacological Perspective. 61
30337988 2018
21
A novel mutation in the conserved sequence of vascular endothelial growth factor receptor 3 leads to primary lymphoedema. 61
29896974 2018
22
From fish embryos to human patients: lymphangiogenesis in development and disease. 61
29800868 2018
23
A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon. 61
30071673 2018
24
Primary Congenital Lymphedema. 61
29762243 2018
25
Warty Fingers and Toes in a Child With Congenital Lymphedema: Elephantiasis Nostras Verrucosa. 61
29710245 2018
26
Congenital lymphangioma circumscriptum of vulva presenting as multiple giant mass lesions: a case report and literature review. 61
29484773 2018
27
Unusual Cause of Gastrointestinal Bleeding in a Patient with Turner Syndrome. 61
30022918 2018
28
Herpetic ocular manifestations in a patient with GATA2 deficiency. 61
29942189 2018
29
Modified enteromesenteric bridging operation for primary lymphedema. 61
30337509 2018
30
[Lymphedema complicated with verrucous papillomatosis]. 61
31448007 2018
31
Near-Infrared Fluorescence Lymphatic Imaging of a Toddler With Congenital Lymphedema. 61
28356336 2017
32
[Primary lymphedema due to Milroy disease]. 61
26818397 2017
33
Atypical retiform hemangioendothelioma arising in a patient with Milroy disease: a case report and review of the literature. 61
27730656 2017
34
[Primary congenital lymphedema: Milroy disease: the first case observed in the Department of Pediatrics at the University Hospital Yalgado Ouedraogo, Ouagadougou]. 61
28748022 2017
35
Penile Reconstruction with Skin Grafts and Dermal Matrices: Indications and Management. 61
28868232 2017
36
Cervical Stimulation in the Treatment of Children with Lymphedema of All Four Extremities: A Case Report and Literature Review. 61
28337356 2017
37
Milroy Disease or Primary Congenital Lymphedema Associated With Invasive Squamous Cell Carcinoma. 61
27374380 2016
38
Rare Variants in LAMA5 Gene associated with FLT4 and FOXC2 Mutations in Primary Lymphedema May Contribute to Severity. 61
29908552 2016
39
An unusual case of Corynebacterium striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease. 61
27751312 2016
40
"You're naked, you're vulnerable": Sexual well-being and body image of women with lower limb lymphedema. 61
27434105 2016
41
Autologous Lymph Node Transfers. 61
26372688 2016
42
Exome sequencing for prenatal diagnosis of fetuses with sonographic abnormalities. 61
26275891 2015
43
Island nail flap in the treatment of foot macrodactyly of the first ray in children: report of two cases. 61
26238609 2015
44
Congenital focal lymphedema as a diagnostic clue to tuberous sclerosis complex: report of two cases diagnosed by ultrasound. 61
25616615 2015
45
Antenatal presentation of hereditary lymphedema type I. 61
25896638 2015
46
A NOVEL FLT4 GENE MUTATION AND MR LYMPHANGIOGRAPHY IN A CHINESE FAMILY WITH MILROY DISEASE. 61
26714373 2015
47
A Novel Missense Mutation in FLT4 Causes Autosomal Recessive Hereditary Lymphedema. 61
26091405 2015
48
Complex decongestive physical therapy and low-level laser therapy for the treatment of pediatric congenital lymphedema: a case report. 61
26180372 2015
49
Autosomal Dominant Microcephaly Associated With Congenital Lymphedema and Chorioretinopathy Due to a Novel Mutation in KIF11. 61
25764055 2015
50
Stewart-Treves Syndrome of the Lower Extremity. 61
26312726 2015
51
Spectrum of myeloid neoplasms and immune deficiency associated with germline GATA2 mutations. 61
25619630 2015
52
Distant metastases in a young woman with Stewart-Treves syndrome demonstrated by an FDG-PET/CT scan. 61
24561687 2014
53
Hypohidrotic ectodermal dysplasia, osteopetrosis, lymphedema, and immunodeficiency in an infant with multiple opportunistic infections. 61
23405946 2014
54
Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: five novel mutations and review of the literature. 61
25115524 2014
55
Congenital segmental lymphedema in tuberous sclerosis complex with associated subependymal giant cell astrocytomas treated with Mammalian target of rapamycin inhibitors. 61
24056156 2014
56
A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease. 61
24744435 2014
57
Vascularized lymph node flap transfer and lymphovenous anastomosis for klippel-trenaunay syndrome with congenital lymphedema. 61
25289360 2014
58
Lymphedema in tuberous sclerosis complex. 61
24668795 2014
59
Lymphedema in a 7-year-old boy infected with Wuchereria bancrofti in Sierra Leone: a case report. 61
24561072 2014
60
Congenital lymphedema complicated by pain and psychological distress: case report. 61
23615316 2014
61
Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. 61
24163130 2014
62
A novel FLT4 mutation identified in a patient with Milroy disease. 61
25109169 2014
63
Adaptations in the treatment of congenital lymphedema centered on the quality of life. 61
24715912 2014
64
Endovascular repair of an infected ruptured isolated iliac artery aneurysm combined with congenital lymphedema: report of a case. 61
22549906 2013
65
Acquired microcystic lymphatic malformation of the distal upper extremity mimicking verrucae vulgaris. 61
23876174 2013
66
Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema. 61
23410910 2013
67
Evaluation of Clinical Manifestations in Patients with Severe Lymphedema with and without CCBE1 Mutations. 61
23653581 2013
68
Primary congenital lymphedema complicated by hydrops fetalis: a case report and review of the literature. 61
23533860 2013
69
Cutaneous epithelioid clear cells angiosarcoma in a young woman with congenital lymphedema. 61
24078891 2013
70
FLT4/VEGFR3 and Milroy disease: novel mutations, a review of published variants and database update. 61
23074044 2013
71
Squamous cell carcinoma arising from congenital lymphedema. 61
27489627 2013
72
Four generations of rare familial lymphedema (Milroy disease). 61
23751338 2013
73
Kampo Extract of Shinbuto Improved Refractory Diarrhea in Milroy's Disease. 61
24278839 2013
74
Penile and sexual rehabilitation in a patient with lymphedema of the penis. 61
23485846 2013
75
Congenital lymphedema: another unique and gender specific stigmata of tuberous sclerosis? 61
23144114 2012
76
Surgical treatment of congenital lymphedema. 61
23036288 2012
77
The godoy & godoy cervical stimulation technique in the treatment of primary congenital lymphedema. 61
25396036 2012
78
Prenatal diagnosis of Milroy's primary congenital lymphedema. 61
22795109 2012
79
Cornelia de Lange syndrome with NIPBL mutation and mosaic Turner syndrome in the same individual. 61
22676896 2012
80
[Congenital Milroy Oedema: a case report of a family]. 61
22730636 2012
81
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. 61
22284827 2012
82
Prenatal diagnosis of Milroy disease. 61
22021048 2011
83
Primary lymphedema with coarctation of the aorta: possible new syndrome or variant of Irons-Bianchi syndrome? 61
21954173 2011
84
The role of lymphoscintigraphy in diagnosis and monitor the response of physiotherapeutic technique in congenital lymphedema. 61
21368595 2011
85
Congenital lymphedema with tuberous sclerosis and clinical Hirschsprung disease. 61
20738790 2011
86
Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. 61
21164289 2011
87
Home-made compression stockings and shoes of a cotton-polyester material in the treatment of primary congenital lymphedema. 61
20882431 2010
88
Macrodystrophia lipomatosa: four case reports. 61
20969776 2010
89
Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans. 61
20826270 2010
90
[Identification of VEGFR3 gene mutation in a Chinese family with autosomal dominant primary congenital lymphoedema]. 61
20677139 2010
91
Agenesis of the corpus callosum and congenital lymphedema: A novel recognizable syndrome? 61
20583147 2010
92
A new classification system for primary lymphatic dysplasias based on phenotype. 61
20447153 2010
93
Re: "conjunctival edema and distichiasis in association with congenital lymphedema of the lower legs". 61
20489560 2010
94
Lymphatic dysfunction, not aplasia, underlies Milroy disease. 61
20536741 2010
95
Milroy's primary congenital lymphedema in a male infant and review of the literature. 61
20555004 2010
96
Surgical treatment of elephantiasis of the feet in congenital lymphedema to facilitate the use of a compression mechanism. 61
20463829 2010
97
[A newborn with swollen feet]. 61
20456778 2010
98
Tall stature and gonadal dysgenesis in a non-mosaic girl 45,X. 61
20197675 2010
99
Purpura-associated congenital lymphedema. 61
19620038 2009
100
Puffy feet in an 11-month-old infant: a quiz. Milroy disease. 61
19997714 2009
101
Hereditary palmoplantar keratoderma associated with primary (congenital) lymphedema. 61
19725273 2009
102
Recessive primary congenital lymphoedema caused by a VEGFR3 mutation. 61
19289394 2009
103
Lymphangiectasia of the vulva accompanying congenital lymphedema. 61
19450406 2009
104
Conjunctival edema and distichiasis in association with congenital lymphedema of the lower legs. 61
19300167 2009
105
Congenital lymphedema-lymphangiectasia associated with scrotal angiokeratoma (Fordyce Type) and hearing impairment. 61
18496391 2008
106
Congenital lymphedema of the upper extremity. A case report. 61
18385633 2008
107
Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear. 61
18212550 2008
108
Lymphatic endothelial cells, lymphedematous lymphangiogenesis, and molecular control of edema formation. 54
19093784 2008
109
Phenotypic characterization of primary lymphedema. 54
18519967 2008
110
Lymphedema, cardiac septal defects, and characteristic facies: possible new case of Irons-Bianchi syndrome. 61
17853470 2007
111
Identification of a novel VEGFR-3 missense mutation in a Chinese family with hereditary lymphedema type I. 54
17945164 2007
112
Turner syndrome: diagnosis and management. 61
17708142 2007
113
Fluorescence microlymphography: diagnostic potential in lymphedema and basis for the measurement of lymphatic pressure and flow velocity. 61
17853615 2007
114
Functional magnetic resonance evidence of cortical alterations in a case of reversible congenital lymphedema of the lower limb: a pilot study. 61
17539461 2007
115
Three children with Milroy disease and de novo mutations in VEGFR3. 61
17250670 2007
116
Milroy Disease 61
20301417 2006
117
Prenatal sonographic diagnosis of milroy congenital lymphedema. 61
16567442 2006
118
Familial congenital non-immune hydrops, chylothorax, and pulmonary lymphangiectasia. 61
16419129 2006
119
[Exudative enteropathy in congenital lymphedema-lymphangiectasia syndrome]. 61
16432772 2006
120
Primary congenital lymphedema involving all limbs and genitalia. 61
16519001 2005
121
[Stewart-Treves syndrome]. 61
16420866 2005
122
Hydrops fetalis: an unusual prenatal presentation of hereditary congenital lymphedema. 61
16231305 2005
123
The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis. 54
16081467 2005
124
Recurrent giant fibroepithelial stromal polyp of the vulva associated with congenital lymphedema. 61
15963814 2005
125
Aplasia cutis congenita, skull defect, brain heterotopia, and intestinal lymphangiectasia. 61
15578573 2005
126
Serum level of VEGF-D in patients with primary lymphedema. 54
15693535 2004
127
Disarticulation of the left upper extremity for treatment of giant primary lymphedema--case report. 61
15693537 2004
128
Klinefelter's syndrome presenting with leg ulcers. 61
15365265 2004
129
Images in clinical medicine. Congenital lymphedema. 61
14762199 2004
130
[Giant scrotal lymphedema caused by Milroy's disease]. 61
14639853 2003
131
[Recurrent erysipelas and bilateral congenital lymphedema]. 61
12855125 2003
132
Tuberous sclerosis and congenital lymphedema. 61
12869168 2003
133
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. 61
12853470 2003
134
Hennekam syndrome presenting as nonimmune hydrops fetalis, congenital chylothorax, and congenital pulmonary lymphangiectasia. 61
12794699 2003
135
Cloning, expression and genomic structure of a novel human GNB2L1 gene, which encodes a receptor of activated protein kinase C (RACK). 61
12688536 2003
136
Verruciform xanthoma in association with milroy disease and leaky capillary syndrome. 61
12558846 2003
137
Research perspectives in inherited lymphatic disease. 61
12543715 2002
138
Physiotherapy results in a baby with congenital lymphedema: a follow-up study. 61
12458815 2002
139
Prenatal diagnosis of Milroy's primary congenital lymphedema. 61
12224079 2002
140
Lymphangiogenic gene therapy with minimal blood vascular side effects. 54
12235206 2002
141
[Genetics of lymphedema: from Milroy's disease to cancer investigations]. 54
12162200 2002
142
Lymphoscintigraphic evaluation of congenital lymphedema of the newborn. 61
11953585 2002
143
Congenital lymphedema and distichiasis. 61
11994178 2002
144
Congenital lymphedema presenting with increased nuchal translucency at 13 weeks of gestation. 61
11857608 2002
145
A model for gene therapy of human hereditary lymphedema. 54
11592985 2001
146
VEGFR3 gene structure, regulatory region, and sequence polymorphisms. 54
11292664 2001
147
Congenital lymphedema. 61
11255317 2001
148
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. 54
11175851 2001
149
Segregation analyses and a genome-wide linkage search confirm genetic heterogeneity and suggest oligogenic inheritance in some Milroy congenital primary lymphedema families. 61
11170072 2001
150
Congenital penoscrotal lymphedema complicated by sepsis associated with a streptococcal infection. 61
11138888 2000
151
Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase. 61
10856194 2000
152
Macrodactyly: report of eight cases and review of the literature. 61
10990574 2000
153
Lymphoscintigraphic manifestations of Hennekam syndrome--a case report. 61
10609768 1999
154
Tuberous sclerosis associated with congenital lymphedema. 61
10627220 1999
155
Primary congenital lymphedema. A case report. 61
10544636 1999
156
Cause of primary congenital lymphedema. 61
10225468 1999
157
Acquired vulvar lymphangioma mimicking genital warts. A case report and review of the literature. 61
10235381 1999
158
Mapping of primary congenital lymphedema to the 5q35.3 region. 61
9973292 1999
159
Staged skin and subcutaneous excision for lymphedema: a favorable report of long-term results. 61
9774002 1998
160
Primary lymphedema of the genitalia in children and adolescents. 61
9751400 1998
161
Lymphedema as a cause of unilateral leg swelling: a case report with 6-yr follow-up. 61
9777548 1998
162
Images in vascular medicine. Lymphoscintigraphy in congenital lymphedema. 61
10102673 1998
163
[Turner's syndrome. Relationship between the karyotypes and malformations and associated diseases in 23 patients]. 61
9382349 1997
164
Possible new autosomal recessive syndrome of lymphedema, hydroceles, atrial septal defect, and characteristic facial changes. 61
8957515 1996
165
Congenital lymphedema in a calf with lymph node dysplasia or aplasia. 61
8519924 1995
166
Klippel-Trénaunay syndrome with multiple pulmonary emboli--an unusual cause of progressive pulmonary dysfunction. 61
7707572 1995
167
Lymphangiosarcoma in late-onset hereditary lymphedema: case report and nosological implications. 61
7747790 1995
168
[Primary conjunctival-palpebral lymphedema and Milroy disease]. 61
7722228 1994
169
Developmental disorders of the lymphatic system. 61
8121193 1993
170
Stasis papillomatosis. Clinical features, etiopathogenesis and radiological findings. 61
8496488 1993
171
Microlymphatics of human skin. 61
8473066 1993
172
A sibship with a neuronal migration defect, cerebellar hypoplasia and congenital lymphedema. 61
7682675 1993
173
Spinal cord arteriovenous malformation in a person with congenital lymphatic abnormalities. 61
1466873 1992
174
Lymphedema. Clinical signs, diagnosis, and treatment. 61
1484372 1992
175
Perinatal manifestations of maternal yellow nail syndrome. 61
1594340 1992
176
[Computed tomographic symptomatology of lymphedema of the lower extremities]. 61
1796542 1991
177
Chylous ascites with pericardial and pleural effusions in congenital lymphedema. 61
1918861 1991
178
The Noonan-CFC controversy. 61
1867292 1991
179
Hereditary lymphedema in Hereford cattle. 61
2039787 1991
180
[Meige-Milroy-Nonne disease. Report of a case in a six-month-old infant]. 61
2256646 1990
181
Diameters of lymphatic capillaries in patients with different forms of primary lymphedema. 61
2250483 1990
182
Lymphoscintigraphic evaluation of primary congenital lymphedema. 61
1708921 1990
183
[Surgical treatment of lymphedema]. 61
2193082 1990
184
Cryptococcal cellulitis in congenital lymphedema. 61
2184141 1990
185
[Early congenital lymphedema of the lower extremities combined with pachyonychia]. 61
2220066 1990
186
Role of tensor fascia lata musculocutaneous flap in lymphedema of the lower extremity and external genitalia. 61
2817711 1989
187
Whole-body lymphangioscintigraphy: preferred method for initial assessment of the peripheral lymphatic system. 61
2748831 1989
188
Necrotizing fasciitis in congenital lymphedema. Case report. 61
3232486 1988
189
[Hereditary congenital lymphedema with pseudosexual ambiguity]. 61
3221210 1988
190
[Progressive lymphangiokeratoma and angiosarcoma (Stewart-Treves syndrome) in congenital lymphedema]. 61
3378886 1988
191
Dominantly inherited syndrome of microcephaly and congenital lymphedema with normal intelligence. 61
3812569 1987
192
Chylothorax in adult age in association with congenital lymphedema. 61
3817062 1986
193
[Regional hypoplasia of dermal lymphatic vessels--a new variant of congenital lymphedema]. 61
3788187 1986
194
On congenital lymphedema. 61
3706401 1986
195
[Congenital lymphedema]. 61
3537585 1986
196
Dominantly inherited syndrome of microcephaly and congenital lymphedema. 61
4017282 1985
197
Congenital lymphedema in two siblings. 61
4010046 1985
198
[Pseudochondroplastic spondyloepiphyseal dysplasia associated with nonfamilial congenital lymphedema and ichthyosis. Description of a case]. 61
4021947 1985
199
[A case report of congenital lymphedema with chylothorax]. 61
4010098 1985
200
Microlymphaticovenous anastomosis for lymphedema of the breast. 61
3990546 1985
201
Squamous carcinoma of the foot arising in association with long-standing verrucous hyperplasia in a patient with congenital lymphedema. 61
6540138 1984
202
Congenital lymphedema of genitalia and extremities. 61
6499200 1984
203
Autosomal or X-linked recessive syndrome of congenital lymphedema, hypoparathyroidism, nephropathy, prolapsing mitral valve, and brachytelephalangy. 61
6638075 1983
204
[Congenital lymphedema in 2 infants: clinical aspects, differential diagnosis and classification]. 61
6664735 1983
205
[A case of uncomplicated, congenital lymphedema. Review of the literature and presentation of a clinical case]. 61
6846913 1983
206
Congenital lymphedema (Milroy's disease). 61
6862605 1983
207
Use of isosulfan blue for identification of lymphatic vessels: experimental and clinical evaluation. 61
6983249 1982
208
[Phlebography of children with congenital lymphedema of the extremities]. 61
7120771 1982
209
[Fluorescence microlymphography of the medial malleolus in healthy humans and in patients with primary lymphedema]. 61
6176022 1982
210
[Hyperbilirubinemia in congenital lymphedema]. 61
7099775 1982
211
Congenital lymphedema of the penis: a method of reconstruction. 61
7411361 1980
212
[Congenital lymphedema and monosomy X (author's transl)]. 61
509298 1979
213
Surgical management of congenital lymphedema in infants and children. 61
485822 1979
214
Primary lymphedema of the hindlimb in the dog. 61
500466 1979
215
Scintilymphangiography with 99 mTc-antimony sulfide colloid in hereditary lymphedema (Nonne-Milroy diseases). 61
709985 1978
216
[Congenital lymphedema complicated by intracavitary chylous effusion. Description of a case]. 61
916989 1977
217
A syndrome of congenital lymphedema of the upper extremity and associated systemic lymphatic malformations. 61
877843 1977
218
Lymphedema tarda. 61
946512 1976
219
Lymphedema. A clinical review and follow-up study. 61
1187879 1975
220
Lymphangiosarcoma arising in congenital lymphedema. 61
1119828 1975
221
Lymphangiosarcoma and congenital lymphedema of the extremity. 61
4414532 1974
222
Congenital lymphedema and yellow nails. 61
4725148 1973
223
Streptococcal gangrene in an infant with congenital lymphedema. 61
4752232 1973
224
Management of congenital lymphedema in infants and children. 61
4692115 1973
225
[Intra-osseous lymphangiectasis and congenital lymphedema]. 61
4689254 1973
226
Primary congenital lymphedema in infancy evaluated by isotope lymphangiography. 61
5580852 1971
227
[Congenital lymphedema and Turner's syndrome. 2 cases with XX-XO mosaicism]. 61
5100925 1971
228
[Description of a case of sporadic congenital lymphedema associated with chronic steatorrhea]. 61
5436274 1970
229
[A case of sporadic congenital lymphedema associated with chronic steatorrhea]. 61
5434898 1970
230
[Hereditary congenital lymphedema (Milroy-Nonne's disease)]. 61
5805653 1969
231
Congenital lymphedema of the extremities in infants and children. 61
5778343 1969
232
[Sporadic congenital lymphedema. (Description of a case)]. 61
5745331 1968
233
[Congenital lymphedema]. 61
5760840 1968
234
[Hereditary congenital lymphedema]. 61
5674144 1968
235
[A case of idiopathic elephantiasis of the leg (Nonne-Meige-Milroy disease)]. 61
6062560 1967
236
[Case of congenital lymphedema]. 61
6071035 1967
237
Hereditary congenital lymphedema (Milroy's disease). 61
5928104 1966
238
[Congenital lymphedema]. 61
5215501 1965
239
[OBSERVATIONS ON A CASE OF CONGENITAL LYMPHEDEMA]. 61
14281581 1964
240
[ON A RARE CASE OF MALFORMATIVE ACROMELIC NON-FAMILIAL CONGENITAL LYMPHEDEMA]. 61
14164057 1964
241
[DESCRIPTION OF A CASE OF SPORADIC CONGENITAL LYMPHEDEMA ASSOCIATED WITH OTHER CONGENITAL ANOMALIES]. 61
14137809 1964
242
[CONGENITAL LYMPHEDEMA]. 61
14107539 1963
243
[Observations on 2 cases of congenital lymphedema]. 61
13982554 1962
244
[A case of congenital lymphedema]. 61
14476001 1961
245
[On the problem of the clinical picture of Nonne-Meigs-Milroy disease]. 61
13774485 1961
246
[Congenital lymphedema, Milroy-Nonne-Meig disease]. 61
13686448 1961
247
Congenital lymphedema: case report nine years after surgical correction. 61
13484516 1957
248
[Milroy disease]. 61
13294934 1955
249
[Simple primary congenital lymphedema, two cases]. 61
13198704 1954
250
[A case of congenital lymphedema treated with hyaluronidase and ACTH]. 61
13166401 1954
251
[Nonne-Meige-Milroy disease]. 61
13160128 1953
252
Generalized primary lymphangiomas of bone: report of case associated with congenital lymphedema of forearm. 61
14783310 1950
253
[Case of constitutional non-congenital lymphedema praecox of American authors]. 61
24539306 1950
254
[Simple congenital lymphedema or trophedema (nonhereditary Milroy type); case report of a 3 month old girl]. 61
14772076 1950
255
Congenital lymphedema; case report with results of surgical correction. 61
15406525 1950
256
[Contribution to the knowledge of congenital elephantiasis family; Milroy disease]. 61
18110162 1948

Variations for Congenital Lymphedema

Expression for Congenital Lymphedema

Search GEO for disease gene expression data for Congenital Lymphedema.

Pathways for Congenital Lymphedema

Pathways related to Congenital Lymphedema according to GeneCards Suite gene sharing:

(showing 15, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 VEGFD VEGFC PDPN KIF11
2 12.45 VEGFD VEGFC FLT4
3 12.35 VEGFD VEGFC FLT4
4
Show member pathways
12.32 VEGFD VEGFC FLT4
5
Show member pathways
12.27 VEGFD VEGFC FLT4
6
Show member pathways
12 VEGFD VEGFC FLT4
7
Show member pathways
11.87 VEGFD VEGFC FLT4
8
Show member pathways
11.81 VEGFD VEGFC FLT4
9
Show member pathways
11.79 VEGFD VEGFC FLT4
10
Show member pathways
11.5 VEGFC FLT4
11 11.28 VEGFC PDPN FLT4
12 11.17 VEGFD VEGFC
13 11.03 VEGFC FOXC2
14 10.49 VEGFD VEGFC FLT4
15
Show member pathways
10 VEGFD VEGFC FLT4

GO Terms for Congenital Lymphedema

Cellular components related to Congenital Lymphedema according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 VEGFD VEGFC

Biological processes related to Congenital Lymphedema according to GeneCards Suite gene sharing:

(showing 14, show less)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.8 VEGFD VEGFC PDPN FOXC2 FLT4
2 angiogenesis GO:0001525 9.67 VEGFD VEGFC FLT4
3 positive regulation of protein phosphorylation GO:0001934 9.65 VEGFD VEGFC FLT4
4 positive regulation of endothelial cell migration GO:0010595 9.54 FOXC2 FLT4
5 positive chemotaxis GO:0050918 9.52 VEGFD VEGFC
6 positive regulation of cell division GO:0051781 9.51 VEGFD VEGFC
7 positive regulation of endothelial cell proliferation GO:0001938 9.5 VEGFD VEGFC FLT4
8 induction of positive chemotaxis GO:0050930 9.46 VEGFD VEGFC
9 lymph vessel development GO:0001945 9.43 FOXC2 FLT4
10 sprouting angiogenesis GO:0002040 9.43 VEGFD VEGFC FLT4
11 positive regulation of mast cell chemotaxis GO:0060754 9.37 VEGFD VEGFC
12 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFD VEGFC FLT4
13 lymphangiogenesis GO:0001946 9.13 PDPN FOXC2 FLT4
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 8.92 VEGFD VEGFC FOXC2 FLT4

Molecular functions related to Congenital Lymphedema according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 VEGFD VEGFC
2 vascular endothelial growth factor receptor binding GO:0005172 8.96 VEGFD VEGFC
3 vascular endothelial growth factor receptor 3 binding GO:0043185 8.62 VEGFD VEGFC

Sources for Congenital Lymphedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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