MCID: CNG029
MIFTS: 43

Congenital Mesoblastic Nephroma

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Congenital Mesoblastic Nephroma

MalaCards integrated aliases for Congenital Mesoblastic Nephroma:

Name: Congenital Mesoblastic Nephroma 12 73 20 58 15 70
Nephroma, Mesoblastic 44
Mesoblastic Nephroma 17

Classifications:

Orphanet: 58  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:4773
MeSH 44 D018201
NCIt 50 C6569
MESH via Orphanet 45 D018201
ICD10 via Orphanet 33 D41.0
UMLS via Orphanet 71 C1332965
Orphanet 58 ORPHA2665
UMLS 70 C1332965

Summaries for Congenital Mesoblastic Nephroma

Disease Ontology : 12 A kidney cancer that is characterized by the presence of fibroblastic cells.

MalaCards based summary : Congenital Mesoblastic Nephroma, also known as nephroma, mesoblastic, is related to nephroma and cellular congenital mesoblastic nephroma. An important gene associated with Congenital Mesoblastic Nephroma is ETV6 (ETS Variant Transcription Factor 6), and among its related pathways/superpathways are p70S6K Signaling and NFAT and Cardiac Hypertrophy. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include kidney, myeloid and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first... more...

Related Diseases for Congenital Mesoblastic Nephroma

Diseases related to Congenital Mesoblastic Nephroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 nephroma 32.1 WT1 NTRK3 KIT IGF2 ETV6
2 cellular congenital mesoblastic nephroma 31.7 YWHAE VGLL2 SSX2 NUTM2B NTRK3 ETV6
3 breast secretory carcinoma 30.8 NTRK3 ETV6
4 hemihyperplasia, isolated 30.8 WT1 IGF2
5 clear cell sarcoma 30.7 YWHAE WT1 NUTM2B KIT IGF2 CCNB3
6 congenital fibrosarcoma 30.6 VGLL2 NTRK3 NTRK2 NTRK1 ETV6 BTBD1
7 rhabdoid cancer 30.5 WT1 SSX2 SMARCB1 IGF2
8 leiomyoma 30.5 MKI67 KIT IGF2
9 kidney rhabdoid cancer 30.3 YWHAE SMARCB1 NUTM2B CCNB3
10 mesenchymal cell neoplasm 30.3 SSX2 NTRK3 NTRK1 KIT CCNB3
11 spindle cell sarcoma 30.0 VGLL2 SSX2 NTRK3 KIT ETV6 CCNB3
12 wilms tumor 1 30.0 WT1 SMARCB1 NTRK2 IGF2 CTCF AMER1
13 beckwith-wiedemann syndrome 29.7 WT1 SMARCB1 IGF2 CTCF AMER1
14 kidney sarcoma 29.7 YWHAE WT1 VGLL2 SSX2 NUTM2B CCNB3
15 kidney clear cell sarcoma 29.5 YWHAE VGLL2 SMARCB1 NUTM2B NTRK3 CCNB3
16 rhabdomyosarcoma 29.4 WT1 VGLL2 SSX2 SMARCB1 KIT IGF2
17 classic congenital mesoblastic nephroma 11.6
18 infantile myofibromatosis 11.2
19 myofibromatosis, infantile, 1 11.2
20 graham boyle troxell syndrome 11.2
21 polyhydramnios 10.8
22 fibrosarcoma 10.6
23 rare renal tumor 10.6
24 chromosomal triplication 10.5
25 rare tumor 10.5
26 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5
27 hydrops fetalis, nonimmune 10.5
28 lymphatic malformation 7 10.5
29 adult fibrosarcoma 10.4 NTRK3 ETV6
30 pax6-related aniridia 10.4 WT1 IGF2
31 breast adenoid cystic carcinoma 10.4 NTRK3 ETV6
32 benign fibrous mesothelioma 10.4 KIT IGF2
33 lipid-rich carcinoma 10.4 NTRK3 ETV6
34 colon leiomyosarcoma 10.4 WT1 KIT
35 mammary analogue secretory carcinoma 10.4 NTRK3 ETV6
36 pleural lipoma 10.4 KIT IGF2
37 intracranial meningioma 10.4 MKI67 IGF2
38 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.4 KIT ETV6
39 ovarian mixed germ cell neoplasm 10.4 WT1 KIT
40 pulmonary vein stenosis 10.4 MKI67 KIT
41 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.4 KIT ETV6
42 hypereosinophilic syndrome, idiopathic 10.3 WT1 KIT
43 ovarian gonadoblastoma 10.3 WT1 KIT
44 cerebellar angioblastoma 10.3 WT1 NTRK3 ETV6
45 acinar cell carcinoma 10.3 NTRK3 IGF2 ETV6
46 angiokeratoma circumscriptum 10.3 WT1 NTRK1
47 benign breast phyllodes tumor 10.3 MKI67 KIT
48 liver leiomyosarcoma 10.3 WT1 KIT
49 kidney hemangiopericytoma 10.3 SSX2 IGF2
50 ovarian endometrioid stromal sarcoma 10.3 YWHAE WT1

Graphical network of the top 20 diseases related to Congenital Mesoblastic Nephroma:



Diseases related to Congenital Mesoblastic Nephroma

Symptoms & Phenotypes for Congenital Mesoblastic Nephroma

GenomeRNAi Phenotypes related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

26 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 10.15 SSX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.15 WT1 SSX2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.15 WT1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.15 NTRK3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10.15 NTRK1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.15 WT1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-148 10.15 NTRK3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.15 SSX2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.15 KIT NTRK3 WT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.15 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.15 NTRK1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.15 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.15 SMARCB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-191 10.15 SSX2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-194 10.15 SMARCB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-20 10.15 NTRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.15 WT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.15 KIT NTRK3 WT1 SSX2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.15 NTRK3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.15 NTRK3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.15 WT1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.15 NTRK1 WT1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-53 10.15 NTRK1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.15 NTRK1 NTRK3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.15 KIT
26 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.15 NTRK1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-75 10.15 SMARCB1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-77 10.15 SSX2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.15 KIT NTRK1 NTRK3 WT1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.15 KIT
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.15 KIT
32 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.65 NTRK2

MGI Mouse Phenotypes related to Congenital Mesoblastic Nephroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 AGBL4 AMER1 CCNB3 CTCF ETV6 IGF2
2 mortality/aging MP:0010768 9.97 AGBL4 AMER1 CTCF ETV6 IGF2 KIT
3 no phenotypic analysis MP:0003012 9.5 ETV6 IGF2 KIT MKI67 NTRK1 NTRK3
4 reproductive system MP:0005389 9.28 CCNB3 IGF2 KIT NTRK2 NTRK3 NUTM2B

Drugs & Therapeutics for Congenital Mesoblastic Nephroma

Drugs for Congenital Mesoblastic Nephroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Liver Extracts Phase 3
4 Cola Phase 3
5 Narcotics Phase 3
6 Anesthetics Phase 3
7 Anesthetics, Intravenous Phase 3
8 Anesthetics, General Phase 3
9 Analgesics, Opioid Phase 3
10 Analgesics Phase 3
11
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
12
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
13
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
14
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
15
Isophosphamide mustard Phase 1, Phase 2 100427
16 Alkylating Agents Phase 1, Phase 2
17 Etoposide phosphate Phase 1, Phase 2
18 Protein Kinase Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
3 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands Unknown status NCT00757614
4 Renal Tumors Classification, Biology, and Banking Study Recruiting NCT00898365
5 The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Recruiting NCT02402244
6 Focal Adhesion Kinase Expression in Pediatric Renal Tumors Withdrawn NCT01642095

Search NIH Clinical Center for Congenital Mesoblastic Nephroma

Cochrane evidence based reviews: nephroma, mesoblastic

Genetic Tests for Congenital Mesoblastic Nephroma

Anatomical Context for Congenital Mesoblastic Nephroma

MalaCards organs/tissues related to Congenital Mesoblastic Nephroma:

40
Kidney, Myeloid, Liver, Breast, Heart, Thyroid, Salivary Gland

Publications for Congenital Mesoblastic Nephroma

Articles related to Congenital Mesoblastic Nephroma:

(show top 50) (show all 337)
# Title Authors PMID Year
1
WT1 expression and hemihypertrophy in congenital mesoblastic nephroma. 54 61
19011477 2008
2
Duplication of the paternal IGF2 allele in trisomy 11 and elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the cellular or mixed type. 61 54
17639583 2007
3
KIT expression in normal and neoplastic renal tissues: immunohistochemical and molecular genetic analysis. 54 61
15998375 2005
4
Cryptic t(12;15)(p13;q26) producing the ETV6-NTRK3 fusion gene and no loss of IGF2 imprinting in congenital mesoblastic nephroma with trisomy 11: fluorescence in situ hybridization and IGF2 allelic expression analysis. 61 54
12165445 2002
5
ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. 54 61
11743047 2001
6
Insulin-like growth factor II gene expression by congenital mesoblastic nephroma. 54 61
8634785 1995
7
Good prognosis of cellular mesoblastic nephroma with hyperdiploidy and relaxation of imprinting of the maternal IGF2 gene. 54 61
8597855 1995
8
Imaging manifestations of congenital mesoblastic nephroma. 61
33217676 2021
9
Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: experience at a single center in China. 61
33782977 2021
10
NTRK Fusions and Trk Proteins: What are They and How to Test for Them. 61
33794242 2021
11
[Diagnosis and therapy of tumors with NTRK gene fusion]. 61
33258061 2021
12
Prenatal diagnosis of fetal congenital mesoblastic nephroma by ultrasonography combined with MR imaging: A case report and literature review. 61
33546001 2021
13
Imaging of solid congenital abdominal masses: a review of the literature and practical approach to image interpretation. 61
33252758 2020
14
Expanding Phenotype of Schimke Immuno-Osseous Dysplasia: Congenital Anomalies of the Kidneys and of the Urinary Tract and Alteration of NK Cells. 61
33203071 2020
15
Unusual Case of Concurrent Retroperitoneal Congenital Infantile Fibrosarcoma and Cellular Type Congenital Mesoblastic Nephroma. 61
31343481 2020
16
Prenatally Diagnosed Solid Renal Mass. 61
33197486 2020
17
Congenital mesoblastic nephroma is characterised by kinase mutations including EGFR internal tandem duplications, the ETV6-NTRK3 fusion, and the rare KLHL7-BRAF fusion. 61
32590884 2020
18
Renal malignant tumor with the loss of INI1 expression and WT1 positive in a 3-year-old boy: a case report. 61
33209693 2020
19
Lessons learned from the developmental origins of childhood renal cancer. 61
31738020 2020
20
Incidence, treatment, and outcomes of primary and recurrent Non-Wilms renal tumors in children: Report of 109 patients treated at a single institution. 61
32620510 2020
21
Recurrent EGFR alterations in NTRK3 fusion negative congenital mesoblastic nephroma. 61
32490123 2020
22
Diagnostic Utility of BCOR Antibody in Clear Cell Sarcomas of Kidney. 61
31875746 2020
23
NTRK-rearranged mesenchymal tumours: diagnostic challenges, morphological patterns and proposed testing algorithm. 61
32278476 2020
24
Congenital mesoblastic nephroma: a single-centre series. 61
31508997 2020
25
A systematic review and meta-analysis of neurotrophic tyrosine receptor kinase gene fusion frequencies in solid tumors. 61
33425024 2020
26
Re: Recurrent and Metastatic Congenital Mesoblastic Nephroma: Where Does the Evidence Stand? 61
31343939 2019
27
Laparoscopic management of congenital mesoblastic nephroma- case report. 61
31388496 2019
28
Prenatal diagnosis of congenital mesoblastic nephroma: a case with poor prognosis. 61
31466985 2019
29
Paraneoplastic disorders associated with miscellaneous neoplasms with focus on selected soft tissue and Undifferentiated/ rhabdoid malignancies. 61
30819530 2019
30
The clinical presentation, imaging features and differential diagnoses of congenital Wilms tumour. 61
31151974 2019
31
Anaplastic sarcoma of the kidney: Case report and literature review. 61
31007495 2019
32
Neurotrophic tropomyosin or tyrosine receptor kinase (NTRK) genes. 61
30636697 2019
33
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening. 61
30592640 2019
34
Specific computed tomography imaging characteristics of congenital mesoblastic nephroma and correlation with ultrasound and pathology. 61
30145031 2018
35
Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma. 61
29893456 2018
36
Estimated glomerular filtration rate after nephrectomy for Wilms tumor. 61
30003640 2018
37
Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants. 61
29915264 2018
38
Evaluation of renal tumors in children. 61
29733801 2018
39
Fetal biparametric MR imaging in the diagnosis of congenital mesoblastic nephroma. 61
29733803 2018
40
ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study. 61
29286563 2018
41
Use of Pretherapy Core Biopsy in the Diagnosis of Pediatric Renal Tumors. 61
29681695 2018
42
Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. 61
29099503 2018
43
Neonatal solid tumors. 61
28736178 2018
44
Congenital Mesoblastic Nephroma Presenting with Hematuria in a Neonate. 61
30464149 2018
45
A rare cause of neonatal hypertension: Congenital mesoblastic nephroma. 61
30325129 2018
46
Targeting NTRK fusions for the treatment of congenital mesoblastic nephroma. 61
28440051 2018
47
Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand? 61
28856451 2017
48
Congenital mesoblastic nephroma 50 years after its recognition: A narrative review. 61
28124468 2017
49
Unusual Presentation of Metanephric Stromal Tumor in a Neonate. 61
29200690 2017
50
Cellular Congenital Mesoblastic Nephroma in a Newborn. 61
28770142 2017

Variations for Congenital Mesoblastic Nephroma

Expression for Congenital Mesoblastic Nephroma

Search GEO for disease gene expression data for Congenital Mesoblastic Nephroma.

Pathways for Congenital Mesoblastic Nephroma

Pathways related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 YWHAE NTRK3 NTRK2 NTRK1 KIT IGF2
2
Show member pathways
12.65 YWHAE NTRK3 NTRK2 NTRK1 IGF2
3
Show member pathways
12.2 YWHAE NTRK3 NTRK2 NTRK1
4
Show member pathways
12.13 NTRK3 NTRK2 NTRK1 KIT IGF2
5
Show member pathways
12.01 YWHAE NTRK3 NTRK2 NTRK1
6 11.84 WT1 SSX2 NTRK1 ETV6
7 11.79 NTRK3 NTRK2 NTRK1
8
Show member pathways
11.56 NTRK3 NTRK2 NTRK1 KIT IGF2
9 11.53 NTRK3 NTRK2 NTRK1 IGF2
10 11.43 NTRK3 NTRK1 KIT
11
Show member pathways
11.28 NTRK3 NTRK2 NTRK1
12 11.09 YWHAE NTRK2 NTRK1 KIT
13 10.99 NTRK3 NTRK2 NTRK1
14 10.84 YWHAE CCNB3
15 10.8 NTRK3 NTRK2 NTRK1 KIT IGF2
16
Show member pathways
10.5 NTRK2 NTRK1

GO Terms for Congenital Mesoblastic Nephroma

Cellular components related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.26 NTRK3 NTRK2 NTRK1 KIT
2 axon GO:0030424 9.02 YWHAE NTRK3 NTRK2 NTRK1 AGBL4

Biological processes related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.02 SMARCB1 NTRK3 NTRK2 NTRK1 ETV6 BTBD1
2 positive regulation of gene expression GO:0010628 9.91 WT1 NTRK3 NTRK2 KIT CTCF
3 negative regulation of cell proliferation GO:0008285 9.89 WT1 SMARCB1 NTRK1 CTCF AGBL4
4 positive regulation of protein phosphorylation GO:0001934 9.78 NTRK3 NTRK2 NTRK1 IGF2
5 peptidyl-tyrosine phosphorylation GO:0018108 9.71 NTRK3 NTRK2 NTRK1 KIT
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 NTRK3 NTRK2 NTRK1 KIT
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.62 NTRK3 NTRK2 NTRK1 KIT
8 cellular response to nerve growth factor stimulus GO:1990090 9.61 NTRK3 NTRK2 NTRK1
9 central nervous system neuron development GO:0021954 9.56 NTRK2 AGBL4
10 regulation of gene expression by genetic imprinting GO:0006349 9.54 IGF2 CTCF
11 positive regulation of phospholipase C activity GO:0010863 9.52 NTRK3 KIT
12 mechanoreceptor differentiation GO:0042490 9.46 NTRK2 NTRK1
13 positive regulation of kinase activity GO:0033674 9.46 NTRK3 NTRK2 NTRK1 KIT
14 regulation of protein kinase B signaling GO:0051896 9.43 NTRK3 NTRK2 NTRK1
15 positive regulation of MAPK cascade GO:0043410 9.35 NTRK3 NTRK2 NTRK1 KIT IGF2
16 neurotrophin signaling pathway GO:0038179 8.8 NTRK3 NTRK2 NTRK1

Molecular functions related to Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.56 NTRK3 NTRK2 NTRK1 KIT
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 NTRK3 NTRK2 NTRK1 KIT
3 GPI-linked ephrin receptor activity GO:0005004 9.32 NTRK3 NTRK1
4 neurotrophin binding GO:0043121 9.13 NTRK3 NTRK2 NTRK1
5 neurotrophin receptor activity GO:0005030 8.8 NTRK3 NTRK2 NTRK1

Sources for Congenital Mesoblastic Nephroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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