CNF
MCID: CNG116
MIFTS: 33

Congenital Nephrotic Syndrome Finnish Type (CNF)

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Congenital Nephrotic Syndrome Finnish Type

MalaCards integrated aliases for Congenital Nephrotic Syndrome Finnish Type:

Name: Congenital Nephrotic Syndrome Finnish Type 20
Finnish Congenital Nephrotic Syndrome 29 6 70
Nephrosis 1, Congenital, Finnish Type 20
Congenital Nephrotic Syndrome 1 20
Finnish Congenital Nephrosis 20
Nephrosis, Congenital 20
Congenital Nephrosis 6
Nphs1 20
Cnf 20

Classifications:



External Ids:

UMLS 70 C0403399

Summaries for Congenital Nephrotic Syndrome Finnish Type

GARD : 20 Congenital nephrotic syndrome Finnish type is a genetic condition of the kidney that begins early in development during pregnancy or within the first three months of life. The syndrome is characterized by a group of symptoms, including protein in the urine ( proteinuria ), low blood protein levels, high cholesterol levels, and swelling ( nephrotic syndrome ), which progresses rapidly to end-stage kidney disease. Infants with congenital nephrotic syndrome may have failure to thrive and frequent infections. Although more commonly seen in individuals of Finnish descent, congenital nephrotic syndrome Finnish type has been reported worldwide. Congenital nephrotic syndrome Finnish type is caused by mutations in the NPHS1 gene and is inherited in an autosomal recessive manner. At this time, kidney transplantation seems to be the only treatment available for this condition.

MalaCards based summary : Congenital Nephrotic Syndrome Finnish Type, also known as finnish congenital nephrotic syndrome, is related to focal segmental glomerulosclerosis and congenital myasthenic syndrome, and has symptoms including edema An important gene associated with Congenital Nephrotic Syndrome Finnish Type is NPHS1 (NPHS1 Adhesion Molecule, Nephrin), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and Nephrin interactions. Affiliated tissues include kidney, and related phenotype is renal/urinary system.

Related Diseases for Congenital Nephrotic Syndrome Finnish Type

Diseases related to Congenital Nephrotic Syndrome Finnish Type via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 focal segmental glomerulosclerosis 31.1 NPHS1 KIRREL2 FAT1
2 congenital myasthenic syndrome 30.3 NPHS1 FAT1 ALG1
3 nephrotic syndrome, type 1 30.1 TTC21B-AS1 TTC21B NPHS1 KIRREL2 FAT1 ALG1
4 nephrotic syndrome 28.8 TTC21B-AS1 TTC21B NPHS1 KIRREL2 FAT1 ALG1
5 familial nephrotic syndrome 28.8 TTC21B-AS1 TTC21B NPHS1 KIRREL2 FAT1 ALG1
6 ventriculomegaly with cystic kidney disease 11.4
7 nephrotic syndrome, type 2 11.2
8 focal segmental glomerulosclerosis 1 11.1
9 kidney disease 11.1
10 glomerulonephritis 11.1
11 pulmonic stenosis and congenital nephrosis 11.1
12 membranous nephropathy 11.1
13 chronic kidney disease 11.0
14 end stage renal disease 11.0
15 frasier syndrome 11.0
16 wilms tumor 1 11.0
17 lipoid nephrosis 11.0
18 iga glomerulonephritis 11.0
19 proteinuria, chronic benign 11.0
20 hypertension, essential 10.9
21 hypoparathyroidism, sensorineural deafness, and renal disease 10.9
22 denys-drash syndrome 10.9
23 galloway-mowat syndrome 10.9
24 nephrosclerosis 10.9
25 membranoproliferative glomerulonephritis 10.9
26 nephrotic syndrome, type 3 10.9
27 nephrotic syndrome, type 4 10.8
28 nephrotic syndrome, type 20 10.8
29 nephrotic syndrome, type 6 10.8
30 nephrotic syndrome, type 5, with or without ocular abnormalities 10.8
31 coenzyme q10 deficiency, primary, 6 10.8
32 nephrotic syndrome, type 7 10.8
33 nephrotic syndrome, type 9 10.8
34 nephrotic syndrome, type 11 10.8
35 nephrotic syndrome, type 12 10.8
36 nephrotic syndrome, type 14 10.8
37 nephrotic syndrome, type 15 10.8
38 nephrotic syndrome, type 17 10.8
39 nephrotic syndrome, type 18 10.8
40 nephrotic syndrome, type 21 10.8
41 nephrotic syndrome, type 22 10.8
42 nephrotic syndrome, type 23 10.8
43 nephrotic syndrome, type 24 10.8
44 cakut 10.8
45 renal hypertension 10.8
46 athetosis 10.8
47 diffuse mesangial sclerosis 10.8
48 nail-patella syndrome 10.8
49 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 10.8
50 wolf-hirschhorn syndrome 10.8

Graphical network of the top 20 diseases related to Congenital Nephrotic Syndrome Finnish Type:



Diseases related to Congenital Nephrotic Syndrome Finnish Type

Symptoms & Phenotypes for Congenital Nephrotic Syndrome Finnish Type

UMLS symptoms related to Congenital Nephrotic Syndrome Finnish Type:


edema

MGI Mouse Phenotypes related to Congenital Nephrotic Syndrome Finnish Type:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 FAT1 KIRREL2 NPHS1 TTC21B

Drugs & Therapeutics for Congenital Nephrotic Syndrome Finnish Type

Search Clinical Trials , NIH Clinical Center for Congenital Nephrotic Syndrome Finnish Type

Genetic Tests for Congenital Nephrotic Syndrome Finnish Type

Genetic tests related to Congenital Nephrotic Syndrome Finnish Type:

# Genetic test Affiliating Genes
1 Finnish Congenital Nephrotic Syndrome 29 NPHS1

Anatomical Context for Congenital Nephrotic Syndrome Finnish Type

MalaCards organs/tissues related to Congenital Nephrotic Syndrome Finnish Type:

40
Kidney

Publications for Congenital Nephrotic Syndrome Finnish Type

Articles related to Congenital Nephrotic Syndrome Finnish Type:

(show top 50) (show all 84)
# Title Authors PMID Year
1
Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome. 61 6
20507940 2010
2
Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome. 6 61
11317351 2001
3
Elevated frequency and allelic heterogeneity of congenital nephrotic syndrome, Finnish type, in the old order Mennonites. 61 6
10577936 1999
4
Whole-genome sequencing of patients with rare diseases in a national health system. 6
32581362 2020
5
Treatment and outcome of congenital nephrotic syndrome. 6
29474669 2019
6
Analysis of 14 Patients With Congenital Nephrotic Syndrome. 6
31456999 2019
7
Screening of the LAMB2, WT1, NPHS1, and NPHS2 Genes in Pediatric Nephrotic Syndrome. 6
30013592 2018
8
Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations. 6
28780565 2017
9
Spectrum of mutations in Chinese children with steroid-resistant nephrotic syndrome. 6
28204945 2017
10
Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management. 6
28117080 2017
11
Three Novel Mutations in the NPHS1 Gene in Vietnamese Patients with Congenital Nephrotic Syndrome. 6
28392951 2017
12
NPHS1 gene mutations confirm congenital nephrotic syndrome in four Brazilian cases: A novel mutation is described. 6
26560236 2016
13
Novel NPHS1 gene mutations in a Chinese family with congenital nephrotic syndrome. 6
27019444 2016
14
Rapid Response to Cyclosporin A and Favorable Renal Outcome in Nongenetic Versus Genetic Steroid-Resistant Nephrotic Syndrome. 6
26668027 2016
15
Targeted next-generation sequencing in steroid-resistant nephrotic syndrome: mutations in multiple glomerular genes may influence disease severity. 6
25407002 2015
16
Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome. 6
25720465 2015
17
A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. 6
25349199 2015
18
RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease. 6
25525159 2015
19
Novel NPHS1 splice site mutations in a Chinese child with congenital nephrotic syndrome. 6
25729976 2015
20
Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation. 6
24682440 2014
21
Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years. 6
24902943 2014
22
Mutational analysis of podocyte genes in children with sporadic steroid-resistant nephrotic syndrome. 6
25501161 2014
23
Rapid detection of monogenic causes of childhood-onset steroid-resistant nephrotic syndrome. 6
24742477 2014
24
Functional analysis of NPHS1 mutations in Japanese patients. 6
24142548 2014
25
Congenital nephrotic syndrome with prolonged renal survival without renal replacement therapy. 6
23949594 2013
26
NPHS1 gene mutations in children with Nephrotic Syndrome in northwest Iran. 6
24498843 2013
27
Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction in chaperone interactions. 6
24303155 2013
28
A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families. 6
23595123 2013
29
Rituximab treatment for recurrence of nephrotic syndrome in a pediatric patient after renal transplantation for congenital nephrotic syndrome of Finnish type. 6
21672106 2012
30
A spectrum of novel NPHS1 and NPHS2 gene mutations in pediatric nephrotic syndrome patients from Pakistan. 6
22565185 2012
31
Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients. 6
22732337 2012
32
Mutation analysis of NPHS1 in a worldwide cohort of congenital nephrotic syndrome patients. 6
22584503 2012
33
Genetic basis of congenital and infantile nephrotic syndromes. 6
22099579 2011
34
Two novel NPHS1 mutations in a Chinese family with congenital nephrotic syndrome. 6
22009864 2011
35
Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome. 6
21415313 2011
36
Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome. 6
20798252 2010
37
The molecular basis of autosomal recessive diseases among the Arabs and Druze in Israel. 6
20852892 2010
38
Nineteen novel NPHS1 mutations in a worldwide cohort of patients with congenital nephrotic syndrome (CNS). 6
20172850 2010
39
Nephrin mutations cause childhood- and adult-onset focal segmental glomerulosclerosis. 6
19812541 2009
40
Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains. 6
19443487 2009
41
NPHS1 gene mutation in Japanese patients with congenital nephrotic syndrome. 6
19321760 2009
42
Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations. 6
19406966 2009
43
Neutropenia in congenital nephrotic syndrome of the Finnish type: role of urinary ceruloplasmin loss. 6
19423745 2009
44
Genetic forms of nephrotic syndrome: a single-center experience in Brussels. 6
18709391 2009
45
Two Korean infants with genetically confirmed congenital nephrotic syndrome of Finnish type. 6
19194555 2009
46
Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome. 6
18503012 2008
47
Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome. 6
18614772 2008
48
A familial childhood-onset relapsing nephrotic syndrome. 6
17290294 2007
49
Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). 6
17371932 2007
50
Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type. 6
16518627 2006

Variations for Congenital Nephrotic Syndrome Finnish Type

ClinVar genetic disease variations for Congenital Nephrotic Syndrome Finnish Type:

6 (show top 50) (show all 448)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NPHS1 NM_004646.3(NPHS1):c.2206G>A (p.Val736Met) SNV Pathogenic 430877 rs1131692245 GRCh37: 19:36335011-36335011
GRCh38: 19:35844109-35844109
2 NPHS1 NM_004646.3(NPHS1):c.1756A>G (p.Arg586Gly) SNV Pathogenic 180463 rs730880174 GRCh37: 19:36336572-36336572
GRCh38: 19:35845670-35845670
3 NPHS1 NM_004646.3(NPHS1):c.736G>T (p.Glu246Ter) SNV Pathogenic 56521 rs386833959 GRCh37: 19:36340242-36340242
GRCh38: 19:35849340-35849340
4 NPHS1 NM_004646.3(NPHS1):c.609-2A>C SNV Pathogenic 56517 rs386833955 GRCh37: 19:36340557-36340557
GRCh38: 19:35849655-35849655
5 NPHS1 NM_004646.3(NPHS1):c.2515del (p.Gln839fs) Deletion Pathogenic 56479 rs386833918 GRCh37: 19:36333174-36333174
GRCh38: 19:35842272-35842272
6 NPHS1 NM_004646.3(NPHS1):c.3250del (p.Val1084fs) Deletion Pathogenic 56496 rs386833935 GRCh37: 19:36322581-36322581
GRCh38: 19:35831679-35831679
7 NPHS1 NM_004646.3(NPHS1):c.2606_2607dup (p.Asn870fs) Duplication Pathogenic 56482 rs386833921 GRCh37: 19:36333081-36333082
GRCh38: 19:35842179-35842180
8 NPHS1 NM_004646.3(NPHS1):c.1758-8_1785del Deletion Pathogenic 56449 rs386833891 GRCh37: 19:36336415-36336450
GRCh38: 19:35845513-35845548
9 NPHS1 NM_004646.3(NPHS1):c.793T>C (p.Cys265Arg) SNV Pathogenic 6874 rs267606917 GRCh37: 19:36340185-36340185
GRCh38: 19:35849283-35849283
10 NPHS1 NPHS1, 1-BP INS, 3250G Insertion Pathogenic 6869 GRCh37:
GRCh38:
11 NPHS1 NM_004646.3(NPHS1):c.740G>A (p.Trp247Ter) SNV Pathogenic 813498 rs1599845689 GRCh37: 19:36340238-36340238
GRCh38: 19:35849336-35849336
12 NPHS1 NM_004646.3(NPHS1):c.2536_2539CTAA[1] (p.Thr847fs) Microsatellite Pathogenic 555946 rs1244884053 GRCh37: 19:36333146-36333149
GRCh38: 19:35842244-35842247
13 NPHS1 NM_004646.3(NPHS1):c.1096A>C (p.Ser366Arg) SNV Pathogenic 56420 rs386833864 GRCh37: 19:36339613-36339613
GRCh38: 19:35848711-35848711
14 NPHS1 NM_004646.3(NPHS1):c.3523_3524del (p.Leu1175fs) Deletion Pathogenic 807454 rs1420307327 GRCh37: 19:36321816-36321817
GRCh38: 19:35830914-35830915
15 NPHS1 NM_004646.3(NPHS1):c.468C>G (p.Tyr156Ter) SNV Pathogenic 56505 rs386833943 GRCh37: 19:36341921-36341921
GRCh38: 19:35851019-35851019
16 NPHS1 NM_004646.4(NPHS1):c.3481+1G>T SNV Pathogenic 928578 GRCh37: 19:36321954-36321954
GRCh38: 19:35831052-35831052
17 NPHS1 NM_004646.3(NPHS1):c.532C>T (p.Gln178Ter) SNV Pathogenic 56513 rs386833951 GRCh37: 19:36341342-36341342
GRCh38: 19:35850440-35850440
18 NPHS1 NM_004646.4(NPHS1):c.1235del (p.Gly412fs) Deletion Pathogenic 843023 GRCh37: 19:36339235-36339235
GRCh38: 19:35848333-35848333
19 NPHS1 NM_004646.3(NPHS1):c.614_621delinsTT (p.Thr205_Arg207delinsIle) Indel Pathogenic 56518 rs1555763603 GRCh37: 19:36340543-36340550
GRCh38: 19:35849641-35849648
20 NPHS1 NM_004646.3(NPHS1):c.3027C>G (p.Tyr1009Ter) SNV Pathogenic 553429 rs762184939 GRCh37: 19:36330221-36330221
GRCh38: 19:35839319-35839319
21 NPHS1 NM_004646.3(NPHS1):c.802C>T (p.Arg268Ter) SNV Pathogenic 496273 rs749341977 GRCh37: 19:36340176-36340176
GRCh38: 19:35849274-35849274
22 NPHS1 NM_004646.4(NPHS1):c.249C>G (p.Tyr83Ter) SNV Pathogenic 992391 GRCh37: 19:36342384-36342384
GRCh38: 19:35851482-35851482
23 TTC21B-AS1 , TTC21B NM_024753.5(TTC21B):c.626C>T (p.Pro209Leu) SNV Pathogenic 30935 rs140511594 GRCh37: 2:166797621-166797621
GRCh38: 2:165941111-165941111
24 NPHS1 NM_004646.3(NPHS1):c.1928T>C (p.Leu643Pro) SNV Pathogenic 56456 rs386833898 GRCh37: 19:36336272-36336272
GRCh38: 19:35845370-35845370
25 NPHS1 NM_004646.3(NPHS1):c.3325C>T (p.Arg1109Ter) SNV Pathogenic 6867 rs137853042 GRCh37: 19:36322260-36322260
GRCh38: 19:35831358-35831358
26 NPHS1 NM_004646.3(NPHS1):c.1339G>A (p.Glu447Lys) SNV Pathogenic 6872 rs28939695 GRCh37: 19:36339044-36339044
GRCh38: 19:35848142-35848142
27 NPHS1 NM_004646.3(NPHS1):c.3478C>T (p.Arg1160Ter) SNV Pathogenic 6873 rs267606919 GRCh37: 19:36321958-36321958
GRCh38: 19:35831056-35831056
28 NPHS1 NM_004646.3(NPHS1):c.1099C>T (p.Arg367Cys) SNV Pathogenic 56421 rs386833865 GRCh37: 19:36339610-36339610
GRCh38: 19:35848708-35848708
29 NPHS1 NM_004646.3(NPHS1):c.3250dup (p.Val1084fs) Duplication Pathogenic 56497 rs386833935 GRCh37: 19:36322580-36322581
GRCh38: 19:35831678-35831679
30 NPHS1 NM_004646.3(NPHS1):c.2479C>T (p.Arg827Ter) SNV Pathogenic 632927 rs140018064 GRCh37: 19:36333308-36333308
GRCh38: 19:35842406-35842406
31 NPHS1 NM_004646.3(NPHS1):c.2335-1G>A SNV Pathogenic 188734 rs150038620 GRCh37: 19:36333453-36333453
GRCh38: 19:35842551-35842551
32 NPHS1 NM_004646.3(NPHS1):c.121_122del (p.Leu41fs) Deletion Pathogenic 56431 rs386833873 GRCh37: 19:36342511-36342512
GRCh38: 19:35851609-35851610
33 NPHS1 NM_004646.3(NPHS1):c.1868G>T (p.Cys623Phe) SNV Pathogenic/Likely pathogenic 56453 rs386833895 GRCh37: 19:36336332-36336332
GRCh38: 19:35845430-35845430
34 NPHS1 NM_004646.3(NPHS1):c.1701C>A (p.Cys567Ter) SNV Pathogenic/Likely pathogenic 56445 rs386833887 GRCh37: 19:36336627-36336627
GRCh38: 19:35845725-35845725
35 NPHS1 NM_004646.3(NPHS1):c.1379G>A (p.Arg460Gln) SNV Pathogenic/Likely pathogenic 56438 rs386833880 GRCh37: 19:36339004-36339004
GRCh38: 19:35848102-35848102
36 NPHS1 NM_004646.3(NPHS1):c.2417C>A (p.Ala806Asp) SNV Pathogenic/Likely pathogenic 56473 rs386833912 GRCh37: 19:36333370-36333370
GRCh38: 19:35842468-35842468
37 NPHS1 NM_004646.3(NPHS1):c.2663+2T>G SNV Pathogenic/Likely pathogenic 496271 rs762392183 GRCh37: 19:36333024-36333024
GRCh38: 19:35842122-35842122
38 NPHS1 NM_004646.3(NPHS1):c.2928G>T (p.Arg976Ser) SNV Pathogenic/Likely pathogenic 188761 rs138656762 GRCh37: 19:36330320-36330320
GRCh38: 19:35839418-35839418
39 NPHS1 NM_004646.3(NPHS1):c.3442C>T (p.Gln1148Ter) SNV Pathogenic/Likely pathogenic 189074 rs150855173 GRCh37: 19:36321994-36321994
GRCh38: 19:35831092-35831092
40 NPHS1 NM_004646.3(NPHS1):c.619del (p.Arg207fs) Deletion Pathogenic/Likely pathogenic 370188 rs778217926 GRCh37: 19:36340545-36340545
GRCh38: 19:35849643-35849643
41 NPHS1 NM_004646.3(NPHS1):c.565G>T (p.Glu189Ter) SNV Pathogenic/Likely pathogenic 188816 rs139598219 GRCh37: 19:36341309-36341309
GRCh38: 19:35850407-35850407
42 NPHS1 NM_004646.3(NPHS1):c.515_517del (p.Thr172del) Deletion Pathogenic/Likely pathogenic 56509 rs386833947 GRCh37: 19:36341872-36341874
GRCh38: 19:35850970-35850972
43 NPHS1 NM_004646.3(NPHS1):c.139del (p.Ala47fs) Deletion Pathogenic/Likely pathogenic 56440 rs386833882 GRCh37: 19:36342494-36342494
GRCh38: 19:35851592-35851592
44 NPHS1 NM_004646.3(NPHS1):c.1481del (p.Ser494fs) Deletion Pathogenic/Likely pathogenic 56441 rs386833883 GRCh37: 19:36337056-36337056
GRCh38: 19:35846154-35846154
45 NPHS1 NM_004646.3(NPHS1):c.808G>T (p.Gly270Cys) SNV Pathogenic/Likely pathogenic 56523 rs386833961 GRCh37: 19:36340170-36340170
GRCh38: 19:35849268-35849268
46 NPHS1 NM_004646.3(NPHS1):c.692C>A (p.Ser231Ter) SNV Likely pathogenic 56520 rs386833958 GRCh37: 19:36340472-36340472
GRCh38: 19:35849570-35849570
47 NPHS1 NM_004646.3(NPHS1):c.661_662del (p.Ser221fs) Deletion Likely pathogenic 56519 rs386833957 GRCh37: 19:36340502-36340503
GRCh38: 19:35849600-35849601
48 NPHS1 NM_004646.3(NPHS1):c.886G>A (p.Ala296Thr) SNV Likely pathogenic 56524 rs386833962 GRCh37: 19:36340004-36340004
GRCh38: 19:35849102-35849102
49 NPHS1 NM_004646.3(NPHS1):c.3312-1G>A SNV Likely pathogenic 189146 rs786204729 GRCh37: 19:36322274-36322274
GRCh38: 19:35831372-35831372
50 NPHS1 NM_004646.3(NPHS1):c.3388-1G>A SNV Likely pathogenic 180467 rs730880176 GRCh37: 19:36322049-36322049
GRCh38: 19:35831147-35831147

Expression for Congenital Nephrotic Syndrome Finnish Type

Search GEO for disease gene expression data for Congenital Nephrotic Syndrome Finnish Type.

Pathways for Congenital Nephrotic Syndrome Finnish Type

Pathways related to Congenital Nephrotic Syndrome Finnish Type according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.67 NPHS1 KIRREL2 FAT1
2 10.3 NPHS1 KIRREL2

GO Terms for Congenital Nephrotic Syndrome Finnish Type

Cellular components related to Congenital Nephrotic Syndrome Finnish Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.13 NPHS1 KIRREL2 FAT1
2 slit diaphragm GO:0036057 8.62 NPHS1 KIRREL2

Biological processes related to Congenital Nephrotic Syndrome Finnish Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.13 NPHS1 KIRREL2 FAT1
2 cell-cell adhesion GO:0098609 8.8 NPHS1 KIRREL2 FAT1

Molecular functions related to Congenital Nephrotic Syndrome Finnish Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 NPHS1 KIRREL2

Sources for Congenital Nephrotic Syndrome Finnish Type

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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