MCID: CNG117
MIFTS: 14

Congenital Nonhemolytic Jaundice

Categories: Rare diseases

Aliases & Classifications for Congenital Nonhemolytic Jaundice

MalaCards integrated aliases for Congenital Nonhemolytic Jaundice:

Name: Congenital Nonhemolytic Jaundice 54
Gilbert Disease 74

Classifications:



External Ids:

UMLS 74 C0017551

Summaries for Congenital Nonhemolytic Jaundice

MalaCards based summary : Congenital Nonhemolytic Jaundice, also known as gilbert disease, is related to crigler-najjar syndrome, type i and encephalopathy. The drugs Ritonavir and Zinc have been mentioned in the context of this disorder. Affiliated tissues include liver.

Related Diseases for Congenital Nonhemolytic Jaundice

Diseases related to Congenital Nonhemolytic Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 crigler-najjar syndrome, type i 10.1
2 encephalopathy 10.1

Symptoms & Phenotypes for Congenital Nonhemolytic Jaundice

Drugs & Therapeutics for Congenital Nonhemolytic Jaundice

Drugs for Congenital Nonhemolytic Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
4
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 27284 23925
5
Deferasirox Approved, Investigational Phase 4 201530-41-8 5493381
6
Deferoxamine Approved, Investigational Phase 4 70-51-9 2973
7
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
8 Anti-HIV Agents Phase 4
9 Anti-Infective Agents Phase 4
10
protease inhibitors Phase 4
11 HIV Protease Inhibitors Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Atazanavir Sulfate Phase 4
14 Dermatologic Agents Phase 4,Phase 3
15 Anti-Retroviral Agents Phase 4
16 Cytochrome P-450 CYP3A Inhibitors Phase 4
17 Trace Elements Phase 4
18 Antiviral Agents Phase 4
19
Bilirubin Phase 4 635-65-4, 69853-43-6 21252250 5280352
20 Nutrients Phase 4
21 Micronutrients Phase 4
22 Astringents Phase 4
23 Liver Extracts Phase 4
24 Siderophores Phase 4
25 Iron Chelating Agents Phase 4
26 Chelating Agents Phase 4
27 alanine Phase 4
28 Gastrointestinal Agents Phase 4
29 N-Methylaspartate Phase 4
30 Cholagogues and Choleretics Phase 4
31 Aspartic Acid Phase 4
32
leucovorin Approved Phase 3 58-05-9 143 6006
33
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
35 Antimetabolites, Antineoplastic Phase 3
36 Nucleic Acid Synthesis Inhibitors Phase 3
37 Antirheumatic Agents Phase 3
38 Immunologic Factors Phase 3
39 Vitamin B9 Phase 3
40 Folate Phase 3
41 Immunosuppressive Agents Phase 3
42 Vitamin B Complex Phase 3
43 Folic Acid Antagonists Phase 3
44 Antimetabolites Phase 3
45
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
46
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
47
Lapatinib Approved March 2007, Investigational Phase 1, Phase 2 231277-92-2, 388082-78-8 208908 9941095
48 Antimitotic Agents Phase 1, Phase 2
49 Albumin-Bound Paclitaxel Phase 1, Phase 2
50 Protein Kinase Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Atazanavir/Ritonavir and Zinc Pharmacokinetic Study Completed NCT01475227 Phase 4 1 Solvazinc tablet, day 2 to day 15;1 Solvazinc tablet, day 15 to day 28
2 Pilot Study for Patients With Poor Response to Deferasirox Completed NCT00749515 Phase 4 Deferoxamine;Deferasirox
3 The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders Terminated NCT02472509 Phase 4 Ursodeoxycholic Acid
4 A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants Completed NCT01941940 Phase 3 Tocilizumab;DMARDs
5 Study Of White Blood Cells In The Cerebrospinal Fluid And Blood Of Patients With Relapsing Forms Of Multiple Sclerosis Completed NCT00469378 Phase 2 firategrast
6 Lapatinib With Carboplatin and Paclitaxel in Esophagus and Gastroesophageal Junction (GEJ) Terminated NCT01395537 Phase 1, Phase 2 Carboplatin AUC;Paclitaxel;lapatinib
7 Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of BI 201335 NA in Healthy Male Subjects Completed NCT02182362 Phase 1 BI 201335 NA;Placebo
8 Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia Completed NCT00383318
9 Biomarker for Gilbert Disease (BioGilbert) Recruiting NCT02712138

Search NIH Clinical Center for Congenital Nonhemolytic Jaundice

Genetic Tests for Congenital Nonhemolytic Jaundice

Anatomical Context for Congenital Nonhemolytic Jaundice

MalaCards organs/tissues related to Congenital Nonhemolytic Jaundice:

42
Liver

Publications for Congenital Nonhemolytic Jaundice

Articles related to Congenital Nonhemolytic Jaundice:

# Title Authors Year
1
Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin. Report of two cases. ( 26181050 )
2016
2
Non-specific drug-metabolizing enzyme activity in Gilbert disease. ( 6440117 )
1984
3
Congenital nonhemolytic jaundice (Crigler-Najjar) with visceral bilirubinosis and onset of encephalopathy at age 15. ( 5656569 )
1968
4
METABOLISM AND DISPOSITION OF C14-BILIRUBIN IN CONGENITAL NONHEMOLYTIC JAUNDICE. ( 14083163 )
1963
5
Congenital nonhemolytic jaundice (Crigler-Najjar syndrome): report of a case. ( 13932187 )
1963
6
Studies of glucuronidation in 3 infants with familial congenital nonhemolytic jaundice. ( 13908495 )
1962
7
Congenital nonhemolytic jaundice with disease of the central nervous system. ( 13359057 )
1956

Variations for Congenital Nonhemolytic Jaundice

Expression for Congenital Nonhemolytic Jaundice

Search GEO for disease gene expression data for Congenital Nonhemolytic Jaundice.

Pathways for Congenital Nonhemolytic Jaundice

GO Terms for Congenital Nonhemolytic Jaundice

Sources for Congenital Nonhemolytic Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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