CRS
MCID: CNG124
MIFTS: 45

Congenital Rubella (CRS)

Categories: Eye diseases, Fetal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Congenital Rubella

MalaCards integrated aliases for Congenital Rubella:

Name: Congenital Rubella 52 17
Congenital Rubella Syndrome 52 58 71 32
Crs 52 58 47
Mother-to-Child Transmission of Rubella Syndrome 58
Fetal Rubella Syndrome 58
Rubella Congenital 52

Characteristics:

Orphanet epidemiological data:

58
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Developmental anomalies during embryogenesis
Teratologic disorders
Rare infectious diseases


Summaries for Congenital Rubella

NIH Rare Diseases : 52 Congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes German measles (rubella) during pregnancy. Congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. After the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby. The most common problems are hearing loss due to damage to the nerve pathways from the inner ear to the brain (sensorineural hearing loss ), ocular abnormalities (cataract , infantile glaucoma , and pigmentary retinopathy ) and heart problems. Other symptoms and signs may include intrauterine growth retardation, prematurity , stillbirth, miscarriage, neurological problems (intellectual disability , low muscle tone, very small head), liver and spleen enlargement (hepatosplenomegaly ), jaundice , skin problems, anemia , hormonal problems, and other issues. The number of babies born with congenital rubella is much less since the rubella vaccine was developed. Pregnant women who are not vaccinated for rubella and who have not had the disease in the past risk infecting themselves and their unborn baby. Please visit the link from the Centers for Diseases Control and Prevention (CDC) to learn more about rubella vaccination: Rubella (German Measles) Vaccination

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to mechanical strabismus and bacteriuria. An important gene associated with Congenital Rubella is CAT (Catalase), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are cataract and neurological speech impairment

Wikipedia : 74 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 555)
# Related Disease Score Top Affiliating Genes
1 mechanical strabismus 29.4 TPO CD40LG
2 bacteriuria 29.3 CD40LG CAT
3 systemic scleroderma 29.1 TPO CD40LG
4 celiac disease 1 28.6 TPO CD40LG
5 peripheral nervous system disease 28.6 CD40LG CAT
6 rubella 11.8
7 craniosynostosis 1 11.7
8 constricting bands, congenital 11.4
9 pseudoainhum 11.4
10 car t cell therapy-associated cytokine release syndrome 11.3
11 cerebral creatine deficiency syndrome 1 11.2
12 craniosynostosis 5 11.2
13 measles 10.7
14 cataract 10.6
15 branchiootic syndrome 1 10.6
16 exanthem 10.6
17 hair whorl 10.5
18 creatinine clearance quantitative trait locus 10.5
19 mumps 10.5
20 rapidly involuting congenital hemangioma 10.4
21 patent ductus arteriosus 1 10.4
22 periodontitis 10.3
23 microcephaly 10.3
24 thrombocytopenia 10.3
25 diabetes mellitus 10.3
26 congestive heart failure 10.3
27 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
28 microphthalmia 10.3
29 scleroderma, familial progressive 10.3
30 crest syndrome 10.3
31 limited scleroderma 10.3
32 leukemia, acute myeloid 10.3
33 benign mesothelioma 10.2
34 autism 10.2
35 triiodothyronine receptor auxiliary protein 10.2
36 purpura 10.2
37 colorectal cancer 10.2
38 ocular motor apraxia 10.2
39 rectum cancer 10.2
40 myeloid leukemia 10.2
41 dentinogenesis imperfecta type 2 10.2
42 gastric cancer 10.2
43 yemenite deaf-blind hypopigmentation syndrome 10.2
44 encephalitis 10.2
45 pseudomyxoma peritonei 10.2
46 hypertension, essential 10.1
47 dermatitis 10.1
48 contact dermatitis 10.1
49 allergic encephalomyelitis 10.1
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cataract 58 31 hallmark (90%) Very frequent (99-80%) HP:0000518
2 neurological speech impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0002167
3 sensorineural hearing impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0000407
4 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
5 intellectual disability 58 31 frequent (33%) Frequent (79-30%) HP:0001249
6 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
7 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
8 muscular hypotonia 58 31 frequent (33%) Frequent (79-30%) HP:0001252
9 microcephaly 58 31 frequent (33%) Frequent (79-30%) HP:0000252
10 visual impairment 58 31 frequent (33%) Frequent (79-30%) HP:0000505
11 short stature 58 31 frequent (33%) Frequent (79-30%) HP:0004322
12 abnormality of retinal pigmentation 58 31 frequent (33%) Frequent (79-30%) HP:0007703
13 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
14 skin rash 58 31 frequent (33%) Frequent (79-30%) HP:0000988
15 nystagmus 58 31 frequent (33%) Frequent (79-30%) HP:0000639
16 strabismus 58 31 frequent (33%) Frequent (79-30%) HP:0000486
17 atrial septal defect 58 31 frequent (33%) Frequent (79-30%) HP:0001631
18 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
19 glaucoma 58 31 frequent (33%) Frequent (79-30%) HP:0000501
20 abnormality of the fontanelles or cranial sutures 58 31 frequent (33%) Frequent (79-30%) HP:0000235
21 microphthalmia 58 31 frequent (33%) Frequent (79-30%) HP:0000568
22 patent ductus arteriosus 58 31 frequent (33%) Frequent (79-30%) HP:0001643
23 ventricular septal defect 58 31 frequent (33%) Frequent (79-30%) HP:0001629
24 aplasia/hypoplasia of the iris 58 31 frequent (33%) Frequent (79-30%) HP:0008053
25 abnormality of the pulmonary artery 58 31 frequent (33%) Frequent (79-30%) HP:0004414
26 spastic diplegia 58 31 frequent (33%) Frequent (79-30%) HP:0001264
27 corneal opacity 58 31 occasional (7.5%) Occasional (29-5%) HP:0007957
28 type i diabetes mellitus 58 31 occasional (7.5%) Occasional (29-5%) HP:0100651
29 abnormality of the metaphysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000944
30 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
31 seizure 31 occasional (7.5%) HP:0001250
32 seizures 58 Occasional (29-5%)

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2, Phase 3
2 Immunologic Factors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessing Immunogenicity of Measles-Rubella Vaccine at 6 and 9 Months of Age Unknown status NCT03071575 Phase 4
2 Immunogenicity & Safety of Bio Farma's Measles-Rubella (MR) Vaccine in Indonesian Infants (Bridging Study) Completed NCT04183114 Phase 2, Phase 3
3 Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China Unknown status NCT02231983
4 Clinical Audit On Management Of Congenital Heart Disease In Assiut Children University Hospital Not yet recruiting NCT03850223

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

40
Heart, Skin, Brain, Liver, Spleen, Testes, Eye

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 1693)
# Title Authors PMID Year
1
Clinical features and aetiology of cerebral palsy in children from Cross River State, Nigeria. 61
31959596 2020
2
The status of rubella IgG antibody titer between antenatal and postnatal among pregnant non-immune to rubella. 61
32574108 2020
3
Faster waning of the rubella specific immune response in young pregnant women immunized with MMR at 15 months. 61
32569402 2020
4
Effectiveness of Combined Direct and Indirect Revascularization for Moyamoya Disease with Concurrent Congenital Rubella Syndrome. 61
32105870 2020
5
Progress Toward Rubella Elimination - Western Pacific Region, 2000-2019. 61
32555136 2020
6
Congenital infections as contributors to the onset of diabetes in children: A longitudinal study in the United States, 2001-2017. 61
31820549 2020
7
ToRCH-screening in pediatric cataract revisited: A North Indian tertiary care centre study. 61
32317443 2020
8
Spatiotemporal proximity of rubella cases to the occurrence of congenital rubella syndrome in Yogyakarta, Indonesia. 61
32483106 2020
9
The 'Dangerous Cocktail': an epidemiological survey on the attitude of a population of pregnant women towards some pregnancy risk factors. 61
31373265 2020
10
Elimination of congenital rubella: a seroprevalence study of pregnant women and women of childbearing age in Italy. 61
31674859 2020
11
Strategies for elimination of rubella in pregnancy and of congenital rubella syndrome in high and upper-middle income countries. 61
32490275 2020
12
Sero-prevalence of rubella among pregnant women in Sub-Saharan Africa: a meta-analysis. 61
32195620 2020
13
Rubella IgM epidemiology in the pre-rubella vaccination era in Uganda. 61
32164592 2020
14
Seroprevalence of Rubella Virus-specific Antibodies in Women and the Diagnostic Efficacy of Enzyme-linked Immunoassay and Rapid Immunochromatographic Tests. 61
32292661 2020
15
Descriptive epidemiology of rubella disease and associated virus strains in Uganda. 61
31598987 2020
16
Rubella seroprevalence in pregnant women living with and without HIV in Soweto, South Africa. 61
31863878 2020
17
Pluripotent Stem Cell-Based Models: A Peephole into Virus Infections during Early Pregnancy. 61
32110999 2020
18
Epidemiology of Congenital Rubella Syndrome (CRS) in India, 2016-18, based on data from sentinel surveillance. 61
32012162 2020
19
Safety profile of rubella vaccine administered to pregnant women: A systematic review of pregnancy related adverse events following immunisation, including congenital rubella syndrome and congenital rubella infection in the foetus or infant. 61
31839467 2020
20
Long-term outcomes of survivors of neonatal insults: A systematic review and meta-analysis. 61
32330163 2020
21
Seroprevalence of rubella in pregnant women in Southern Morocco. 61
32373261 2020
22
Measles and rubella seroprevalence among adults in Georgia in 2015: helping guide the elimination efforts. 61
31822310 2019
23
Characteristics of Patent Ductus Arteriosus in Congenital Rubella Syndrome. 61
31745134 2019
24
Need for heightening awareness of congenital rubella syndrome in the United States. 61
31379318 2019
25
50 Years Ago in The Journal of Pediatrics: Congenital Rubella: Immune Response of the Neonate and Diagnosis by Demonstration of Specific IgM Antibodies. 61
31561779 2019
26
Severe Pulmonary Arteriopathy in a Neonate with Congenital Rubella Syndrome and Patent Ductus Arteriosus. 61
31724543 2019
27
Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination - Worldwide, 2000-2018. 61
31581161 2019
28
Measles and rubella in Italy, e-learning course for health care workers. 61
31850867 2019
29
Phylogeography of rubella virus in Asia: Vaccination and demography shape synchronous outbreaks. 61
31201039 2019
30
Rubella transmission and the risk of congenital rubella syndrome in Liberia: a need to introduce rubella-containing vaccine in the routine immunization program. 61
31533658 2019
31
Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism. 61
31546693 2019
32
Post Vaccine Rubella During a Measles Outbreak: Clinical Case. 61
31851892 2019
33
Rubella seroprevalence and demographic feature analysis in pregnant women from Southern Pakistan. 61
31431775 2019
34
Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells. 61
31405163 2019
35
First MRI With New Cochlear Implant With Rotatable Internal Magnet System and Proposal for Standardization of Reporting Magnet-Related Artifact Size. 61
31219967 2019
36
Molecular aspects of the teratogenesis of rubella virus. 61
31455418 2019
37
Congenital supravalvular and subvalvular pulmonary stenosis with hypoplastic pulmonary annulus associated with congenital rubella syndrome. 61
31296628 2019
38
Comparison of two commercial ELISA kits for detection of rubella specific IgM in suspected congenital rubella syndrome cases and rubella IgG antibodies in a serosurvey of pregnant women. 61
30782464 2019
39
Genetic Characterization of Measles and Rubella Viruses Detected Through Global Measles and Rubella Elimination Surveillance, 2016-2018. 61
31269012 2019
40
Diabetic ketoacidosis in a child with congenital rubella syndrome: A case report and review of literature. 61
31405663 2019
41
Congenital rubella syndrome at tertiary care hospital in North India: Results from a retrospective assessment. 61
31158287 2019
42
Rubella virus, Toxoplasma gondii and Treponema pallidum congenital infections among full term delivered women in an urban area of Tanzania: a call for improved antenatal care. 61
31656468 2019
43
Seroprevalence and durability of rubella virus antibodies in a highly immunized population. 61
31126859 2019
44
Assessment of Economic Burden of Concurrent Measles and Rubella Outbreaks, Romania, 2011-2012. 61
31107215 2019
45
Awareness and Factors Associated with Health Care Worker's Knowledge on Rubella Infection: A Study after the Introduction of Rubella Vaccine in Tanzania. 61
31091685 2019
46
Progress Toward Measles Elimination - European Region, 2009-2018. 61
31048675 2019
47
Congenital Rubella Syndrome Surveillance in South Africa Using a Sentinel Site Approach: A Cross-sectional Study. 61
30203002 2019
48
Predicting congenital rubella syndrome in Japan, 2018-2019. 61
30807870 2019
49
Rubella Vaccination Coverage Among Women of Childbearing Age in Vietnam. 61
31100981 2019
50
Biological view of vaccination described by mathematical modellings: from rubella to dengue vaccines. 61
31499609 2019

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.2 UNG CD40LG

GO Terms for Congenital Rubella

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.37 CD40LG CAT
2 negative regulation of apoptotic process GO:0043066 9.33 UNG CD40LG CAT
3 response to oxidative stress GO:0006979 9.32 TPO CAT
4 cellular oxidant detoxification GO:0098869 9.26 TPO CAT
5 hydrogen peroxide catabolic process GO:0042744 8.96 TPO CAT
6 isotype switching GO:0045190 8.62 UNG CD40LG

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 TPO CAT
2 peroxidase activity GO:0004601 8.62 TPO CAT

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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