CRS
MCID: CNG124
MIFTS: 49

Congenital Rubella (CRS)

Categories: Eye diseases, Fetal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Congenital Rubella

MalaCards integrated aliases for Congenital Rubella:

Name: Congenital Rubella 54 17
Congenital Rubella Syndrome 54 60 74
Crs 54 60 49
Mother-to-Child Transmission of Rubella Syndrome 60
Fetal Rubella Syndrome 60
Rubella Congenital 54

Characteristics:

Orphanet epidemiological data:

60
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



Summaries for Congenital Rubella

NIH Rare Diseases : 54 Congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes German measles (rubella) during pregnancy. Congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. After the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby. The most common problems are hearing loss due to damage to the nerve pathways from the inner ear to the brain (sensorineural hearing loss), ocular abnormalities (cataract, infantile glaucoma, and pigmentary retinopathy) and heart problems. Other symptoms and signs may include intrauterine growth retardation, prematurity, stillbirth, miscarriage, neurological problems (intellectual disability, low muscle tone, very small head), liver and spleen enlargement (hepatosplenomegaly), jaundice, skin problems, anemia, hormonal problems, and other issues.  The number of babies born with congenital rubella is much less since the rubella vaccine was developed. Pregnant women who are not vaccinated for rubella and who have not had the disease in the past risk infecting themselves and their unborn baby. Please visit the link from the Centers for Diseases Control and Prevention (CDC) to learn more about rubella vaccination: Rubella (German Measles) Vaccination

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to cd40 ligand deficiency and immunodeficiency with hyper-igm, type 1. An important gene associated with Congenital Rubella is CAT (Catalase), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart, and related phenotypes are neurological speech impairment and cataract

Wikipedia : 77 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 cd40 ligand deficiency 29.5 CD40LG UNG
2 immunodeficiency with hyper-igm, type 1 29.5 CD40LG UNG
3 rubella 11.8
4 craniosynostosis 1 11.3
5 cerebral creatine deficiency syndrome 1 11.1
6 craniosynostosis 5 11.1
7 measles 10.5
8 frasier syndrome 10.3
9 diabetes mellitus 10.3
10 cataract 10.3
11 cerebrotendinous xanthomatosis 10.2
12 intraocular pressure quantitative trait locus 10.2
13 nodular lymphocyte predominant hodgkin lymphoma 10.2
14 horns in sheep 10.2
15 primary orthostatic tremor 10.2
16 encephalitis 10.1
17 scleroderma, familial progressive 10.1
18 crest syndrome 10.1
19 limited scleroderma 10.1
20 ocular motor apraxia 10.1
21 allergic encephalomyelitis 10.1
22 spondyloenchondrodysplasia 10.1
23 autism 10.1
24 spondylocarpotarsal synostosis syndrome 10.0
25 rere-related disorders 10.0
26 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
27 thrombocytopenia 10.0
28 mumps 10.0
29 pneumonia 10.0
30 thyroiditis 10.0
31 retinoblastoma 10.0
32 multiple sclerosis 10.0
33 hypertension, essential 10.0
34 tetralogy of fallot 10.0
35 acute insulin response 10.0
36 coronary heart disease 1 10.0
37 lymphoma 10.0
38 rapidly involuting congenital hemangioma 10.0
39 light fixation seizure syndrome 9.9
40 pulmonary hypertension 9.9
41 keratoconus 9.9
42 heart disease 9.9
43 hypothyroidism 9.9
44 purpura 9.9
45 hydranencephaly 9.9
46 encephalopathy 9.9
47 immunodeficiency with hyper-igm, type 4 9.9 CD40LG UNG
48 hyperimmunoglobulin syndrome 9.9 CD40LG UNG
49 colorectal cancer 9.9
50 retinitis pigmentosa 9.9

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

60 33 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neurological speech impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0002167
2 cataract 60 33 hallmark (90%) Very frequent (99-80%) HP:0000518
3 sensorineural hearing impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0000407
4 intrauterine growth retardation 60 33 hallmark (90%) Very frequent (99-80%) HP:0001511
5 nystagmus 60 33 frequent (33%) Frequent (79-30%) HP:0000639
6 intellectual disability 60 33 frequent (33%) Frequent (79-30%) HP:0001249
7 muscular hypotonia 60 33 frequent (33%) Frequent (79-30%) HP:0001252
8 splenomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0001744
9 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
10 microcephaly 60 33 frequent (33%) Frequent (79-30%) HP:0000252
11 visual impairment 60 33 frequent (33%) Frequent (79-30%) HP:0000505
12 short stature 60 33 frequent (33%) Frequent (79-30%) HP:0004322
13 abnormality of retinal pigmentation 60 33 frequent (33%) Frequent (79-30%) HP:0007703
14 anemia 60 33 frequent (33%) Frequent (79-30%) HP:0001903
15 strabismus 60 33 frequent (33%) Frequent (79-30%) HP:0000486
16 patent ductus arteriosus 60 33 frequent (33%) Frequent (79-30%) HP:0001643
17 atrial septal defect 60 33 frequent (33%) Frequent (79-30%) HP:0001631
18 thrombocytopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001873
19 microphthalmia 60 33 frequent (33%) Frequent (79-30%) HP:0000568
20 glaucoma 60 33 frequent (33%) Frequent (79-30%) HP:0000501
21 abnormality of the fontanelles or cranial sutures 60 33 frequent (33%) Frequent (79-30%) HP:0000235
22 ventricular septal defect 60 33 frequent (33%) Frequent (79-30%) HP:0001629
23 skin rash 60 33 frequent (33%) Frequent (79-30%) HP:0000988
24 aplasia/hypoplasia of the iris 60 33 frequent (33%) Frequent (79-30%) HP:0008053
25 abnormality of the pulmonary artery 60 33 frequent (33%) Frequent (79-30%) HP:0004414
26 spastic diplegia 60 33 frequent (33%) Frequent (79-30%) HP:0001264
27 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
28 corneal opacity 60 33 occasional (7.5%) Occasional (29-5%) HP:0007957
29 type i diabetes mellitus 60 33 occasional (7.5%) Occasional (29-5%) HP:0100651
30 abnormality of the metaphysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000944
31 jaundice 60 33 occasional (7.5%) Occasional (29-5%) HP:0000952

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4
3
Adenosine Approved, Investigational 58-61-7 60961

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of Age Unknown status NCT03071575 Phase 4
2 Susceptibility Genes in Autism Spectrum Disorders Unknown status NCT02628808

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

42
Skin, Brain, Heart, Liver, Spleen, Eye, Thyroid

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 765)
# Title Authors Year
1
Last cases of rubella and congenital rubella syndrome in Spain, 1997-2016: The success of a vaccination program. ( 30454948 )
2019
2
Clinical manifestations of congenital rubella syndrome: A review of our experience in Vietnam. ( 30503658 )
2019
3
50 Years Ago in The Journal of Pediatrics: Maternal and Congenital Rubella before 1964: Frequency, Clinical Features, and Search for Isoimmune Phenomena. ( 30684990 )
2019
4
Comparison of two commercial ELISA kits for detection of rubella specific IgM in suspected congenital rubella syndrome cases and rubella IgG antibodies in a serosurvey of pregnant women. ( 30782464 )
2019
5
Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection. ( 30806367 )
2019
6
Predicting congenital rubella syndrome in Japan, 2018-2019. ( 30807870 )
2019
7
Aniridia: A Rare Manifestation Of Congenital Rubella Syndrome. ( 30868799 )
2019
8
Rubella infection in pregnancy and congenital rubella in United Kingdom, 2003 to 2016. ( 29766840 )
2018
9
Congenital rubella syndrome: A brief review of public health perspectives. ( 29512566 )
2018
10
Imported Congenital Rubella Syndrome, United States, 2017. ( 29553333 )
2018
11
Progress Toward Rubella and Congenital Rubella Syndrome Control - South-East Asia Region, 2000-2016. ( 29851943 )
2018
12
Congenital Rubella ( 29939656 )
2018
13
Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study. ( 30203002 )
2018
14
Sentinel Surveillance for Congenital Rubella Syndrome - India, 2016-2017. ( 30212443 )
2018
15
The impact of Measles-Rubella vaccination on the morbidity and mortality from Congenital Rubella Syndrome in 92 countries. ( 30285537 )
2018
16
Burden of Congenital Rubella Syndrome (CRS) in Bangladesh: Systematic review of existing literature and transmission modelling of sero-prevalence studies. ( 30289078 )
2018
17
Hospital based surveillance of congenital rubella syndrome cases in the pre-vaccine era in Amhara Regional State, Ethiopia: A base line information for the country. ( 30419036 )
2018
18
An update on epidemiology of congenital rubella syndrome: how far from the World Health Organization goals? ( 28728344 )
2017
19
Lacrimal drainage anomalies in congenital rubella syndrome. ( 29184387 )
2017
20
An infant with congenital rubella syndrome in developing India. ( 29184005 )
2017
21
The end of measles and congenital rubella: an achievable dream? ( 28067934 )
2017
22
Congenital rubella syndrome: an unusual cause of neonatal fulminant hepatic failure. ( 28678001 )
2017
23
Sensory defects and developmental delay among children with congenital rubella syndrome. ( 28406248 )
2017
24
Underreporting of congenital rubella in Italy, 2010-2014. ( 28551878 )
2017
25
Clinically Confirmed Congenital Rubella Syndrome: The Role of Echocardiography. ( 28579716 )
2017
26
Clinical profile of congenital rubella syndrome in Yogyakarta, Indonesia. ( 29068106 )
2017
27
Hospital-based surveillance of congenital rubella syndrome in Indonesia. ( 28091778 )
2017
28
50 Years Ago in The Journal of Pediatrics: Cerebral Lesions in Congenital Rubella Syndrome. ( 28129869 )
2017
29
Progress in rubella and congenital rubella syndrome control and elimination a89 worldwide, 2000a892016. ( 29148274 )
2017
30
The burden of congenital rubella syndrome in the Philippines: results from a retrospective assessment. ( 29184700 )
2017
31
Progress in Rubella and Congenital Rubella Syndrome Control and Elimination - Worldwide, 2000-2016. ( 29145358 )
2017
32
Two Imported Cases of Congenital Rubella Syndrome and Infection-Control Challenges in New York State, 2013-2015. ( 28510706 )
2017
33
Newborn with transient macular rash and thrombocytopenia. Skeletal manifestations of congenital rubella syndrome. ( 28600621 )
2017
34
Erratum to: Underreporting of congenital rubella in Italy, 2010-2014. ( 28695269 )
2017
35
Using the two-source capture-recapture method to estimate the incidence and case ascertainment of congenital rubella syndrome in Australia, 1993-2013. ( 27757254 )
2016
36
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? ( 27343317 )
2016
37
Vaccination in secondary school students expedites rubella control and prevents congenital rubella syndrome. ( 27899091 )
2016
38
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. ( 27606025 )
2016
39
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy. ( 27866768 )
2016
40
Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review. ( 28115948 )
2016
41
A case of congenital rubella syndrome and infection in South-East London in 2015: prevention, diagnosis, and the public health response. ( 27884915 )
2016
42
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. ( 27757248 )
2016
43
Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. ( 27244797 )
2016
44
Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. ( 27002428 )
2016
45
Congenital rubella syndrome with death from interstitial pneumonia. ( 26840886 )
2016
46
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania. ( 27225802 )
2016
47
Congenital Rubella. ( 27732820 )
2016
48
Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review. ( 26962867 )
2016
49
Localization of Viral Antigens Improves Understanding of Congenital Rubella Syndrome Pathophysiology. ( 26870811 )
2016
50
Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome. ( 26870820 )
2016

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG UNG

GO Terms for Congenital Rubella

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 CAT CD40LG
2 response to oxidative stress GO:0006979 9.26 CAT TPO
3 cellular oxidant detoxification GO:0098869 9.16 CAT TPO
4 negative regulation of apoptotic process GO:0043066 9.13 CAT CD40LG UNG
5 hydrogen peroxide catabolic process GO:0042744 8.62 CAT TPO

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 CAT TPO
2 peroxidase activity GO:0004601 8.62 CAT TPO

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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