CRS
MCID: CNG124
MIFTS: 44

Congenital Rubella (CRS)

Categories: Eye diseases, Fetal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Congenital Rubella

MalaCards integrated aliases for Congenital Rubella:

Name: Congenital Rubella 53 17
Congenital Rubella Syndrome 53 59 72 33
Crs 53 59 48
Mother-to-Child Transmission of Rubella Syndrome 59
Fetal Rubella Syndrome 59
Rubella Congenital 53

Characteristics:

Orphanet epidemiological data:

59
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



External Ids:

ICD10 33 P35.0
MESH via Orphanet 45 D012410
ICD10 via Orphanet 34 P35.0
UMLS via Orphanet 73 C0035921
Orphanet 59 ORPHA290
UMLS 72 C0035921

Summaries for Congenital Rubella

NIH Rare Diseases : 53 Congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes German measles (rubella) during pregnancy. Congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. After the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby. The most common problems are hearing loss due to damage to the nerve pathways from the inner ear to the brain (sensorineural hearing loss), ocular abnormalities (cataract, infantile glaucoma, and pigmentary retinopathy) and heart problems. Other symptoms and signs may include intrauterine growth retardation, prematurity, stillbirth, miscarriage, neurological problems (intellectual disability, low muscle tone, very small head), liver and spleen enlargement (hepatosplenomegaly), jaundice, skin problems, anemia, hormonal problems, and other issues. The number of babies born with congenital rubella is much less since the rubella vaccine was developed. Pregnant women who are not vaccinated for rubella and who have not had the disease in the past risk infecting themselves and their unborn baby. Please visit the link from the Centers for Diseases Control and Prevention (CDC) to learn more about rubella vaccination: Rubella (German Measles) Vaccination

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to cd40 ligand deficiency and systemic scleroderma. An important gene associated with Congenital Rubella is CAT (Catalase), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are neurological speech impairment and cataract

Wikipedia : 75 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 531)
# Related Disease Score Top Affiliating Genes
1 cd40 ligand deficiency 29.4 UNG CD40LG
2 systemic scleroderma 28.8 TPO CD40LG
3 autoimmune disease 28.4 TPO CD40LG
4 rubella 11.8
5 craniosynostosis 1 11.7
6 constricting bands, congenital 11.3
7 pseudoainhum 11.3
8 car t cell therapy-associated cytokine release syndrome 11.2
9 cerebral creatine deficiency syndrome 1 11.2
10 craniosynostosis 5 11.2
11 measles 10.7
12 cataract 10.6
13 branchiootic syndrome 1 10.6
14 exanthem 10.5
15 hair whorl 10.5
16 creatinine clearance quantitative trait locus 10.5
17 mumps 10.4
18 rapidly involuting congenital hemangioma 10.4
19 patent ductus arteriosus 1 10.3
20 microcephaly 10.3
21 diabetes mellitus 10.3
22 periodontitis 10.3
23 congestive heart failure 10.3
24 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
25 thrombocytopenia 10.3
26 microphthalmia 10.3
27 triiodothyronine receptor auxiliary protein 10.2
28 gastric cancer 10.2
29 scleroderma, familial progressive 10.2
30 crest syndrome 10.2
31 limited scleroderma 10.2
32 colorectal cancer 10.2
33 benign mesothelioma 10.2
34 autism 10.2
35 purpura 10.2
36 ocular motor apraxia 10.2
37 leukemia, acute myeloid 10.2
38 dentinogenesis imperfecta type 2 10.2
39 rectum cancer 10.2
40 myeloid leukemia 10.2
41 yemenite deaf-blind hypopigmentation syndrome 10.2
42 encephalitis 10.2
43 dermatitis 10.2
44 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
45 cytomegalovirus infection 10.1
46 hypertension, essential 10.1
47 contact dermatitis 10.1
48 pseudomyxoma peritonei 10.1
49 allergic encephalomyelitis 10.1
50 ovarian cancer 10.1

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

59 32 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neurological speech impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0002167
2 cataract 59 32 hallmark (90%) Very frequent (99-80%) HP:0000518
3 sensorineural hearing impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0000407
4 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
5 nystagmus 59 32 frequent (33%) Frequent (79-30%) HP:0000639
6 intellectual disability 59 32 frequent (33%) Frequent (79-30%) HP:0001249
7 muscular hypotonia 59 32 frequent (33%) Frequent (79-30%) HP:0001252
8 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
9 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
10 microcephaly 59 32 frequent (33%) Frequent (79-30%) HP:0000252
11 visual impairment 59 32 frequent (33%) Frequent (79-30%) HP:0000505
12 short stature 59 32 frequent (33%) Frequent (79-30%) HP:0004322
13 abnormality of retinal pigmentation 59 32 frequent (33%) Frequent (79-30%) HP:0007703
14 anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001903
15 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
16 strabismus 59 32 frequent (33%) Frequent (79-30%) HP:0000486
17 patent ductus arteriosus 59 32 frequent (33%) Frequent (79-30%) HP:0001643
18 atrial septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001631
19 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
20 microphthalmia 59 32 frequent (33%) Frequent (79-30%) HP:0000568
21 glaucoma 59 32 frequent (33%) Frequent (79-30%) HP:0000501
22 abnormality of the fontanelles or cranial sutures 59 32 frequent (33%) Frequent (79-30%) HP:0000235
23 ventricular septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001629
24 aplasia/hypoplasia of the iris 59 32 frequent (33%) Frequent (79-30%) HP:0008053
25 abnormality of the pulmonary artery 59 32 frequent (33%) Frequent (79-30%) HP:0004414
26 spastic diplegia 59 32 frequent (33%) Frequent (79-30%) HP:0001264
27 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
28 corneal opacity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007957
29 type i diabetes mellitus 59 32 occasional (7.5%) Occasional (29-5%) HP:0100651
30 abnormality of the metaphysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000944
31 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunologic Factors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessing Immunogenicity of Measles-Rubella Vaccine at 6 and 9 Months of Age Unknown status NCT03071575 Phase 4
2 Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China Unknown status NCT02231983
3 Clinical Audit On Management Of Congenital Heart Disease In Assiut Children University Hospital Not yet recruiting NCT03850223

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

41
Heart, Skin, Brain, Liver, Spleen, Testes, Eye

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 1655)
# Title Authors PMID Year
1
First MRI With New Cochlear Implant With Rotatable Internal Magnet System and Proposal for Standardization of Reporting Magnet-Related Artifact Size. 38
31219967 2019
2
Need for heightening awareness of congenital rubella syndrome in the United States. 38
31379318 2019
3
Rubella seroprevalence and demographic feature analysis in pregnant women from Southern Pakistan. 38
31431775 2019
4
Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells. 38
31405163 2019
5
The 'Dangerous Cocktail': an epidemiological survey on the attitude of a population of pregnant women towards some pregnancy risk factors. 38
31373265 2019
6
Diabetic ketoacidosis in a child with congenital rubella syndrome: A case report and review of literature. 38
31405663 2019
7
Genetic Characterization of Measles and Rubella Viruses Detected Through Global Measles and Rubella Elimination Surveillance, 2016-2018. 38
31269012 2019
8
Comparison of two commercial ELISA kits for detection of rubella specific IgM in suspected congenital rubella syndrome cases and rubella IgG antibodies in a serosurvey of pregnant women. 38
30782464 2019
9
Congenital supravalvular and subvalvular pulmonary stenosis with hypoplastic pulmonary annulus associated with congenital rubella syndrome. 38
31296628 2019
10
Assessment of Economic Burden of Concurrent Measles and Rubella Outbreaks, Romania, 2011-2012. 38
31107215 2019
11
Congenital rubella syndrome at tertiary care hospital in North India: Results from a retrospective assessment. 38
31158287 2019
12
Seroprevalence and durability of rubella virus antibodies in a highly immunized population. 38
31126859 2019
13
Progress Toward Measles Elimination - European Region, 2009-2018. 38
31048675 2019
14
Predicting congenital rubella syndrome in Japan, 2018-2019. 38
30807870 2019
15
Rubella Vaccination Coverage Among Women of Childbearing Age in Vietnam. 38
31100981 2019
16
Phylogeography of rubella virus in Asia: Vaccination and demography shape synchronous outbreaks. 38
31201039 2019
17
Awareness and Factors Associated with Health Care Worker's Knowledge on Rubella Infection: A Study after the Introduction of Rubella Vaccine in Tanzania. 38
31091685 2019
18
Measles and rubella serosurvey identifies rubella immunity gap in young adults of childbearing age in Zambia: The added value of nesting a serological survey within a post-campaign coverage evaluation survey. 38
30905529 2019
19
Rubella (German measles) revisited. 38
30967519 2019
20
Modelling a Supplementary Vaccination Program of Rubella Using the 2012⁻2013 Epidemic Data in Japan. 38
31027277 2019
21
A case of immune-mediated type 1 diabetes mellitus due to congenital rubella ınfection. 38
30943684 2019
22
Rubella outbreak in the school children, Addis Ababa, Ethiopia: February-April 2018. 38
30885148 2019
23
Perception of rubella risk in pregnancy: an epidemiological survey on a sample of pregnant women. 38
30994165 2019
24
Successes and challenges for preventing measles, mumps and rubella by vaccination. 38
30852425 2019
25
50 Years Ago in The Journal of Pediatrics: Maternal and Congenital Rubella before 1964: Frequency, Clinical Features, and Search for Isoimmune Phenomena. 38
30684990 2019
26
Anti-Jo-1 Antibody-positive Interstitial Pneumonia in an Elderly Patient with Congenital Rubella Syndrome. 38
31308343 2019
27
Last cases of rubella and congenital rubella syndrome in Spain, 1997-2016: The success of a vaccination program. 38
30454948 2019
28
Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection. 38
30806367 2019
29
Congenital and perinatal infections. 38
31324308 2019
30
Aniridia: A Rare Manifestation Of Congenital Rubella Syndrome. 38
30868799 2019
31
Seroprevelence of rubella among children suspected of having measles in Gadarif Hospital, Eastern Sudan. 38
31384083 2019
32
The impact of Measles-Rubella vaccination on the morbidity and mortality from Congenital Rubella Syndrome in 92 countries. 38
30285537 2019
33
Clinical manifestations of congenital rubella syndrome: A review of our experience in Vietnam. 38
30503658 2019
34
The risk factors of exposure to rubella among pregnant women in Zaria 2013. 38
30949283 2019
35
Adverse pregnancy outcomes among pregnant women with acute Rubella infections in Mwanza city, Tanzania. 38
30391418 2019
36
A Prospective OCT Study of Rubella Retinopathy. 38
31047196 2018
37
Systemic Associations of Childhood Glaucoma: A Review. 38
30452766 2018
38
Global landscape of measles and rubella surveillance. 38
30318167 2018
39
Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia. 38
30165188 2018
40
Seroprevalance of Rubella in an Urban Infertility Clinic - Observations and Challenges Ahead. 38
30787525 2018
41
Clinical epidemiology of congenital heart disease in Nigerian children, 2012-2017. 38
30230273 2018
42
Burden of Congenital Rubella Syndrome (CRS) in Bangladesh: Systematic review of existing literature and transmission modelling of sero-prevalence studies. 38
30289078 2018
43
Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study. 38
30203002 2018
44
Sentinel Surveillance for Congenital Rubella Syndrome - India, 2016-2017. 38
30212443 2018
45
No. 203-Rubella in Pregnancy. 38
30103885 2018
46
Suppression of Melatonin Secretion in Totally Visually Blind People by Ocular Exposure to White Light: Clinical Characteristics. 38
29625838 2018
47
Congenital Rubella Syndrome in The African Region - Data from Sentinel Surveillance. 38
30957103 2018
48
Epidemiological changes in rubella IgG antibody levels detected in antenatal women from a retrospective rubella seroprevalence study. 38
29209940 2018
49
Measles-Rubella Supplementary Immunization Activity Readiness Assessment - India, 2017-2018. 38
29975677 2018
50
The Impact of Recent Rubella Vaccine Introduction in 5 Countries in The African Region. 38
30957104 2018

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 UNG CD40LG

GO Terms for Congenital Rubella

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 CD40LG CAT
2 response to oxidative stress GO:0006979 9.26 TPO CAT
3 cellular oxidant detoxification GO:0098869 9.16 TPO CAT
4 negative regulation of apoptotic process GO:0043066 9.13 UNG CD40LG CAT
5 hydrogen peroxide catabolic process GO:0042744 8.62 TPO CAT

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 TPO CAT
2 peroxidase activity GO:0004601 8.62 TPO CAT

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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