CRS
MCID: CNG124
MIFTS: 49

Congenital Rubella (CRS)

Categories: Eye diseases, Fetal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Congenital Rubella

MalaCards integrated aliases for Congenital Rubella:

Name: Congenital Rubella 53
Congenital Rubella Syndrome 53 59 73
Crs 53 59 48
Mother-to-Child Transmission of Rubella Syndrome 59
Fetal Rubella Syndrome 59
Rubella Congenital 53

Characteristics:

Orphanet epidemiological data:

59
congenital rubella syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Antenatal,Neonatal; Age of death: embryofetal,infantile,stillbirth;

Classifications:



Summaries for Congenital Rubella

NIH Rare Diseases : 53 Congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes German measles (rubella) during pregnancy. Congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. After the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby. The most common problems are hearing loss due to damage to the nerve pathways from the inner ear to the brain (sensorineural hearing loss), ocular abnormalities (cataract, infantile glaucoma, and pigmentary retinopathy) and heart problems. Other symptoms and signs may include intrauterine growth retardation, prematurity, stillbirth, miscarriage, neurological problems (intellectual disability, low muscle tone, very small head), liver and spleen enlargement (hepatosplenomegaly), jaundice, skin problems, anemia, hormonal problems, and other issues.  The number of babies born with congenital rubella is much less since the rubella vaccine was developed. Pregnant women who are not vaccinated for rubella and who have not had the disease in the past risk infecting themselves and their unborn baby. Please visit the link from the Centers for Diseases Control and Prevention (CDC) to learn more about rubella vaccination: Rubella (German Measles) Vaccination

MalaCards based summary : Congenital Rubella, also known as congenital rubella syndrome, is related to cd40 ligand deficiency and immunodeficiency with hyper-igm, type 1. An important gene associated with Congenital Rubella is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related phenotypes are nystagmus and intellectual disability

Wikipedia : 76 Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted... more...

Related Diseases for Congenital Rubella

Diseases in the Rubella family:

Congenital Rubella

Diseases related to Congenital Rubella via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 cd40 ligand deficiency 29.5 CD40LG UNG
2 immunodeficiency with hyper-igm, type 1 29.5 CD40LG UNG
3 rubella 11.7
4 craniosynostosis 1 11.3
5 pfeiffer syndrome 11.0
6 crouzon syndrome 11.0
7 cerebral creatine deficiency syndrome 1 11.0
8 craniosynostosis 5 11.0
9 central nervous system disease 11.0
10 foxp2-related speech and language disorders 11.0
11 measles 10.5
12 diabetes mellitus 10.3
13 cataract 10.3
14 frasier syndrome 10.2
15 cerebrotendinous xanthomatosis 10.2
16 encephalitis 10.1
17 scleroderma, familial progressive 10.1
18 crest syndrome 10.1
19 limited scleroderma 10.1
20 autism 10.1
21 cytomegalovirus infection 10.1
22 spondylocarpotarsal synostosis syndrome 10.1
23 adamantinoma of long bones 10.0
24 leukemia 10.0
25 primary orthostatic tremor 10.0
26 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
27 thrombocytopenia 10.0
28 mumps 10.0
29 pneumonia 10.0
30 thyroiditis 10.0
31 viral infectious disease 10.0
32 ocular motor apraxia 10.0
33 horns in sheep 10.0
34 allergic encephalomyelitis 10.0
35 breast abscess 9.9 CAT CD40LG
36 cryptosporidiosis 9.9 CAT CD40LG
37 light fixation seizure syndrome 9.9
38 pulmonary hypertension 9.9
39 keratoconus 9.9
40 heart disease 9.9
41 hypothyroidism 9.9
42 agammaglobulinemia 9.9
43 purpura 9.9
44 hydranencephaly 9.9
45 encephalopathy 9.9
46 bacteriuria 9.9 CAT CD40LG
47 colorectal cancer 9.9
48 retinoblastoma 9.9
49 coronary heart disease 1 9.9
50 acute leukemia 9.9

Graphical network of the top 20 diseases related to Congenital Rubella:



Diseases related to Congenital Rubella

Symptoms & Phenotypes for Congenital Rubella

Human phenotypes related to Congenital Rubella:

59 32 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nystagmus 59 32 frequent (33%) Frequent (79-30%) HP:0000639
2 intellectual disability 59 32 frequent (33%) Frequent (79-30%) HP:0001249
3 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
4 muscular hypotonia 59 32 frequent (33%) Frequent (79-30%) HP:0001252
5 neurological speech impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0002167
6 cataract 59 32 hallmark (90%) Very frequent (99-80%) HP:0000518
7 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
8 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
9 corneal opacity 59 32 occasional (7.5%) Occasional (29-5%) HP:0007957
10 microcephaly 59 32 frequent (33%) Frequent (79-30%) HP:0000252
11 sensorineural hearing impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0000407
12 visual impairment 59 32 frequent (33%) Frequent (79-30%) HP:0000505
13 short stature 59 32 frequent (33%) Frequent (79-30%) HP:0004322
14 abnormality of retinal pigmentation 59 32 frequent (33%) Frequent (79-30%) HP:0007703
15 type i diabetes mellitus 59 32 occasional (7.5%) Occasional (29-5%) HP:0100651
16 anemia 59 32 frequent (33%) Frequent (79-30%) HP:0001903
17 abnormality of the metaphysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000944
18 strabismus 59 32 frequent (33%) Frequent (79-30%) HP:0000486
19 patent ductus arteriosus 59 32 frequent (33%) Frequent (79-30%) HP:0001643
20 intrauterine growth retardation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001511
21 atrial septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001631
22 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
23 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
24 microphthalmia 59 32 frequent (33%) Frequent (79-30%) HP:0000568
25 glaucoma 59 32 frequent (33%) Frequent (79-30%) HP:0000501
26 abnormality of the fontanelles or cranial sutures 59 32 frequent (33%) Frequent (79-30%) HP:0000235
27 ventricular septal defect 59 32 frequent (33%) Frequent (79-30%) HP:0001629
28 skin rash 59 32 frequent (33%) Frequent (79-30%) HP:0000988
29 aplasia/hypoplasia of the iris 59 32 frequent (33%) Frequent (79-30%) HP:0008053
30 abnormality of the pulmonary artery 59 32 frequent (33%) Frequent (79-30%) HP:0004414
31 spastic diplegia 59 32 frequent (33%) Frequent (79-30%) HP:0001264

Drugs & Therapeutics for Congenital Rubella

Drugs for Congenital Rubella (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4
2 Vaccines Phase 4
3
Adenosine Approved, Investigational 58-61-7 60961

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Measles-Rubella Vaccine Immunogenicity at 6 and 9 Months of Age Not yet recruiting NCT03071575 Phase 4
2 Susceptibility Genes in Autism Spectrum Disorders Unknown status NCT02628808

Search NIH Clinical Center for Congenital Rubella

Genetic Tests for Congenital Rubella

Anatomical Context for Congenital Rubella

MalaCards organs/tissues related to Congenital Rubella:

41
Skin, Liver, Brain, Heart, Spleen, Eye, B Cells

Publications for Congenital Rubella

Articles related to Congenital Rubella:

(show top 50) (show all 759)
# Title Authors Year
1
Last cases of rubella and congenital rubella syndrome in Spain, 1997-2016: The success of a vaccination program. ( 30454948 )
2019
2
Clinical manifestations of congenital rubella syndrome: A review of our experience in Vietnam. ( 30503658 )
2019
3
Rubella infection in pregnancy and congenital rubella in United Kingdom, 2003 to 2016. ( 29766840 )
2018
4
Congenital rubella syndrome: A brief review of public health perspectives. ( 29512566 )
2018
5
Imported Congenital Rubella Syndrome, United States, 2017. ( 29553333 )
2018
6
Progress Toward Rubella and Congenital Rubella Syndrome Control - South-East Asia Region, 2000-2016. ( 29851943 )
2018
7
Congenital Rubella ( 29939656 )
2018
8
Two Imported Cases of Congenital Rubella Syndrome and Infection-Control Challenges in New York State, 2013-2015. ( 28510706 )
2018
9
Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study. ( 30203002 )
2018
10
Sentinel Surveillance for Congenital Rubella Syndrome - India, 2016-2017. ( 30212443 )
2018
11
The impact of Measles-Rubella vaccination on the morbidity and mortality from Congenital Rubella Syndrome in 92 countries. ( 30285537 )
2018
12
Burden of Congenital Rubella Syndrome (CRS) in Bangladesh: Systematic review of existing literature and transmission modelling of sero-prevalence studies. ( 30289078 )
2018
13
Hospital based surveillance of congenital rubella syndrome cases in the pre-vaccine era in Amhara Regional State, Ethiopia: A base line information for the country. ( 30419036 )
2018
14
An update on epidemiology of congenital rubella syndrome: how far from the World Health Organization goals? ( 28728344 )
2017
15
Lacrimal drainage anomalies in congenital rubella syndrome. ( 29184387 )
2017
16
An infant with congenital rubella syndrome in developing India. ( 29184005 )
2017
17
The end of measles and congenital rubella: an achievable dream? ( 28067934 )
2017
18
Congenital rubella syndrome: an unusual cause of neonatal fulminant hepatic failure. ( 28678001 )
2017
19
Sensory defects and developmental delay among children with congenital rubella syndrome. ( 28406248 )
2017
20
Underreporting of congenital rubella in Italy, 2010-2014. ( 28551878 )
2017
21
Clinically Confirmed Congenital Rubella Syndrome: The Role of Echocardiography. ( 28579716 )
2017
22
Clinical profile of congenital rubella syndrome in Yogyakarta, Indonesia. ( 29068106 )
2017
23
Hospital-based surveillance of congenital rubella syndrome in Indonesia. ( 28091778 )
2017
24
50 Years Ago in The Journal of Pediatrics: Cerebral Lesions in Congenital Rubella Syndrome. ( 28129869 )
2017
25
Progress in rubella and congenital rubella syndrome control and elimination a89 worldwide, 2000a892016. ( 29148274 )
2017
26
Newborn with transient macular rash and thrombocytopenia. Skeletal manifestations of congenital rubella syndrome. ( 28600621 )
2017
27
Erratum to: Underreporting of congenital rubella in Italy, 2010-2014. ( 28695269 )
2017
28
Progress in Rubella and Congenital Rubella Syndrome Control and Elimination - Worldwide, 2000-2016. ( 29145358 )
2017
29
The burden of congenital rubella syndrome in the Philippines: results from a retrospective assessment. ( 29184700 )
2017
30
Using the two-source capture-recapture method to estimate the incidence and case ascertainment of congenital rubella syndrome in Australia, 1993-2013. ( 27757254 )
2016
31
Is birth cohort 1985/9-1990/8 a susceptibility window for congenital rubella syndrome in Taiwan? ( 27343317 )
2016
32
Vaccination in secondary school students expedites rubella control and prevents congenital rubella syndrome. ( 27899091 )
2016
33
Psychiatric manifestations of congenital rubella syndrome: A case report and review of literature. ( 27606025 )
2016
34
Estimating the burden of rubella virus infection and congenital rubella syndrome through a rubella immunity assessment among pregnant women in the Democratic Republic of the Congo: Potential impact on vaccination policy. ( 27866768 )
2016
35
Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review. ( 28115948 )
2016
36
A case of congenital rubella syndrome and infection in South-East London in 2015: prevention, diagnosis, and the public health response. ( 27884915 )
2016
37
An outbreak investigation of congenital rubella syndrome in Solomon Islands, 2013. ( 27757248 )
2016
38
Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers. ( 27244797 )
2016
39
Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature. ( 27002428 )
2016
40
Congenital rubella syndrome with death from interstitial pneumonia. ( 26840886 )
2016
41
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania. ( 27225802 )
2016
42
Congenital Rubella. ( 27732820 )
2016
43
Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review. ( 26962867 )
2016
44
Localization of Viral Antigens Improves Understanding of Congenital Rubella Syndrome Pathophysiology. ( 26870811 )
2016
45
Immunolocalization and Distribution of Rubella Antigen in Fatal Congenital Rubella Syndrome. ( 26870820 )
2016
46
Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability-Adjusted Life Years (DALYs). ( 25115193 )
2016
47
Intracranial epidural hematoma in a newborn with DIC secondary to congenital rubella. ( 26834916 )
2015
48
Rubella and congenital rubella syndrome control and elimination - global progress, 2000-2014. ( 26410894 )
2015
49
Nitric oxide-sensitive pulmonary hypertension in congenital rubella syndrome. ( 25785205 )
2015
50
Prevalence of glaucoma and cataract morphology in congenital rubella syndrome. ( 25840326 )
2015

Variations for Congenital Rubella

Expression for Congenital Rubella

Search GEO for disease gene expression data for Congenital Rubella.

Pathways for Congenital Rubella

Pathways related to Congenital Rubella according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG UNG

GO Terms for Congenital Rubella

Biological processes related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 CAT CD40LG
2 response to oxidative stress GO:0006979 9.26 CAT TPO
3 cellular oxidant detoxification GO:0098869 9.16 CAT TPO
4 negative regulation of apoptotic process GO:0043066 9.13 CAT CD40LG UNG
5 hydrogen peroxide catabolic process GO:0042744 8.62 CAT TPO

Molecular functions related to Congenital Rubella according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.96 CAT TPO
2 peroxidase activity GO:0004601 8.62 CAT TPO

Sources for Congenital Rubella

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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