MCID: CNG033
MIFTS: 38

Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Congenital Syphilis

MalaCards integrated aliases for Congenital Syphilis:

Name: Congenital Syphilis 12 74 58 15 17 32
Syphilis, Congenital 43 71
Mother-to-Child Transmission of Syphilis 58
Syphilis Congenital 54
Mtct of Syphilis 58

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis
Teratologic disorders
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9856
ICD9CM 34 090 090.9
MeSH 43 D013590
NCIt 49 C84649
SNOMED-CT 67 35742006
ICD10 32 A50 A50.9
Orphanet 58 ORPHA499009
UMLS 71 C0039131

Summaries for Congenital Syphilis

Disease Ontology : 12 A syphilis that results in a multisystem infection in the fetus via the placenta.

MalaCards based summary : Congenital Syphilis, also known as syphilis, congenital, is related to late congenital syphilis and early congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Congenital Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and Primary immunodeficiency. The drugs Penicillin G and penicillins have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and liver.

Wikipedia : 74 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

Related Diseases for Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 late congenital syphilis 34.9 DDX41 CD40LG
2 early congenital syphilis 34.1 TPR POLA1 MYH9 CD40LG
3 interstitial keratitis 30.9 UTP6 CD40LG
4 syphilis 30.9 TPR POLA1 MYH9 DDX41 CD79A CD40LG
5 asymptomatic neurosyphilis 30.8 MYH9 CD40LG CD4
6 chorioretinitis 30.4 CD40LG CD4
7 meningoencephalitis 30.2 CD79A CD40LG CD4
8 orchitis 30.2 CD40LG CD4
9 syphilitic meningitis 30.2 CD40LG CD4
10 neuroretinitis 30.1 CD40LG CD4
11 iritis 30.1 CD40LG CD4
12 choroiditis 30.0 CD40LG CD4
13 iridocyclitis 30.0 CD40LG CD4
14 tabes dorsalis 29.8 MYH9 DDX41 CD4
15 cardiovascular syphilis 29.8 TPR DDX41 C19orf33
16 nephrotic syndrome 29.7 PLCE1 NPHS2 NPHS1
17 bronchopneumonia 29.6 CD40LG CD4
18 yaws 29.6 TPR MYH9 EPB41L3 CD40LG
19 membranous nephropathy 29.5 NPHS2 NPHS1 CD79A
20 latent syphilis 29.4 TPR POLA1 MYH9 DDX41 CD40LG CD4
21 glomerulonephritis 29.3 NPHS2 NPHS1 MYH9 CD79A CD40LG
22 secondary syphilis 28.9 TPR POLA1 MYH9 EPB41L3 DDX41 CD79A
23 familial nephrotic syndrome 28.7 PLCE1 NPHS2 NPHS1
24 primary syphilis 28.3 TPR POLA1 MYH9 EPB41L3 DDX41 CD40LG
25 paroxysmal cold hemoglobinuria 11.5
26 hemorrhagic fever-renal syndrome 10.5 CD79A CD40LG
27 c1q nephropathy 10.5 CD79A CD40LG
28 hilar lung carcinoma 10.5 CD79A CD40LG
29 lung hilum cancer 10.5 CD79A CD40LG
30 immunoglobulin g deficiency 10.5 CD79A CD40LG
31 cryofibrinogenemia 10.5 CD79A CD40LG
32 monoclonal paraproteinemia 10.5 CD79A CD40LG
33 ocular toxoplasmosis 10.5 CD79A CD40LG
34 immunodeficiency with hyper-igm, type 1 10.5 CD79A CD40LG
35 heavy chain disease 10.5 CD79A CD40LG
36 immunoglobulin a deficiency 1 10.5 CD79A CD40LG
37 pustulosis palmaris et plantaris 10.5 CD79A CD40LG
38 late yaws 10.4 TPR CD40LG
39 alpha chain disease 10.4 CD79A CD40LG
40 calciphylaxis 10.4 CD79A CD40LG
41 exanthem 10.4
42 dysgammaglobulinemia 10.4 CD79A CD40LG
43 keratitis, hereditary 10.4
44 persistent generalized lymphadenopathy 10.4 CD79A CD40LG
45 periostitis 10.4
46 neurosyphilis 10.4
47 transient pseudohypoaldosteronism 10.4
48 riedel's fibrosing thyroiditis 10.4 CD40LG CD4
49 cork-handlers' disease 10.4 CD40LG CD4
50 acute poststreptococcal glomerulonephritis 10.4 CD79A CD40LG

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to Congenital Syphilis

Symptoms & Phenotypes for Congenital Syphilis

UMLS symptoms related to Congenital Syphilis:


syphilitic chancre

Drugs & Therapeutics for Congenital Syphilis

Drugs for Congenital Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved 61-33-6 5904
2 penicillins
3 Penicillin G Benzathine
4 Penicillin G Procaine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Different Partner Notification Strategies After Antenatal Syphilis Screening Unknown status NCT02262390
2 Preventing Congenital Syphilis Completed NCT02353117
3 Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases in Context of ETMIplus Program, OPS/OMS. Multicentric Study Recruiting NCT04084379
4 Congenital Syphilis at Third- Level Pediatric Hospital. A Retrospective Survey Study of the Last Three Decades Not yet recruiting NCT04137601
5 Point-Of-Care Testing for Congenital Syphilis in Mothers and Newborns: A Proof of Concept Study Withdrawn NCT03814096

Search NIH Clinical Center for Congenital Syphilis

Cochrane evidence based reviews: syphilis, congenital

Genetic Tests for Congenital Syphilis

Anatomical Context for Congenital Syphilis

MalaCards organs/tissues related to Congenital Syphilis:

40
Testes, Bone, Liver, Eye, Brain, Placenta, Spleen

Publications for Congenital Syphilis

Articles related to Congenital Syphilis:

(show top 50) (show all 2075)
# Title Authors PMID Year
1
In utero infection with Treponema pallidum in early pregnancy. 54 61
9061759 1997
2
Laboratory diagnosis of congenital syphilis by immunoglobulin M (IgM) and IgA immunoblotting. 54 61
7496918 1994
3
Comparison of the fluorescent treponemal antibody absorption (FTA-ABS) test with the FTA-ABS double staining test for detection of antitreponemal immunoglobulin M in the 19S fraction of human serum. 54 61
7678016 1993
4
IgM rheumatoid factor removal and performance of the FTA-ABS (IgM) test in congenital syphilis. 54 61
1398661 1992
5
[Specific serologic reactions in the cerebrospinal fluid in congenital syphilis and therapeutic implications]. 54 61
2256636 1990
6
Evaluation of immunoglobulin M western blot analysis in the diagnosis of congenital syphilis. 54 61
2179261 1990
7
Rollet's mixed chancre in Brazilian pregnant women: An unusual case report. 61
31743797 2020
8
Syphilis Notifications and the Triggering Processes for Vertical Transmission: A Cross-Sectional Study. 61
32033272 2020
9
Pediatric otosyphilis-An unusual cause of conductive hearing loss. 61
31737149 2020
10
Managing the Unusual Causes of Fetal Anemia. 61
31505487 2020
11
Enhancing the Routine Screening Infrastructure to Address a Syphilis Epidemic in Miami-Dade County. 61
32004258 2020
12
Evaluation of the WHO/CDC Syphilis Serology Proficiency Programme to support the global elimination of mother-to-child transmission of syphilis: an observational cross-sectional study, 2008-2015. 61
31924629 2020
13
Syphilis Immunoassay Signal Strength Correlates with Active Infection in Pregnant Women. 61
31910464 2020
14
A Nationwide Spatiotemporal Analysis of Syphilis Over 21 Years and Implications for Prevention and Control in China. 61
31237616 2020
15
Congenital syphilis or mercury treatment: dental alterations in a twelfth- or thirteenth-century child from Medinaceli, Soria, Spain. 61
31939991 2020
16
[Inequalities in congenital syphilis trends in the city of Niterói, Brazil, 2007-2016Desigualdades en la tendencia de sífilis congénita en la ciudad de Niterói, Brasil, 2007-2016]. 61
32038724 2020
17
Hydrops fetalis caused by congenital syphilis: An ancient disease? 61
31739773 2019
18
Inequalities in health by regime of affiliation to the health system in events of obligatory notification, Colombia, 2015 61
31860184 2019
19
Cytological diagnosis in a clinically unsuspected case of disseminated BCGosis: A case report. 61
31858747 2019
20
Turning off the tap: sustaining elimination of congenital syphilis through the programme targeting high-risk groups. 61
31656601 2019
21
Syphilis management in pregnancy: a review of guideline recommendations from countries around the world. 61
31884900 2019
22
Gaps to eliminate congenital syphilis in a tertiary care center in THAILAND. 61
31886919 2019
23
Differences between congenital-syphilis presenting as sepsis and neonatal sepsis: A case-control study. 61
31689826 2019
24
Congenital Syphilis. 61
31774960 2019
25
Ending Congenital Syphilis. 61
31710335 2019
26
Case report of eight pregnant women with syphilis. 61
31740278 2019
27
A Romanian experience of syphilis in pregnancy and childbirth. 61
31374436 2019
28
Congenital syphilis: A prospective study of 22 cases diagnosed by PCR. 61
31558291 2019
29
Lessons about the reliability of congenital syphilis and vertical HIV transmission data learned from case reviews in Uruguay: a cross-sectional study. 61
31684892 2019
30
Incidence Trends, Risk Factors, Mortality and Healthcare Utilization in Congenital Syphilis-related Hospitalizations in the United States: A Nationwide Population Analysis. 61
31469777 2019
31
Congenital Syphilis Misdiagnosed as Suspected Nonaccidental Trauma. 61
31537633 2019
32
Syphilis in Pregnancy. 61
31830301 2019
33
An unusual presentation of early congenital syphilis with annular configuration of blisters resembling "string-of-pearls". 61
31177579 2019
34
Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso. 61
30580325 2019
35
[Primary Health Care-Sensitive Hospitalizations in children under one year of age, from 2008 to 2014, in the State of São Paulo, Brazil]. 61
31508742 2019
36
Surveillance for Emerging Threats to Pregnant Women and Infants. 61
31408424 2019
37
[Late congenital syphilis: case report]. 61
31339283 2019
38
Symptomatic congenital syphilis in a tertiary neonatal unit in Cape Town, South Africa: High morbidity and mortality in a preventable disease. 61
31635589 2019
39
Congenital Syphilis as a Measure of Maternal and Child Healthcare, Brazil. 61
31310223 2019
40
Better care for babies: the added value of a modified reverse syphilis testing algorithm for the treatment of congenital syphilis in a maternity Hospital in Central African Republic. 61
31416437 2019
41
Evaluating congenital syphilis in a reverse sequence testing environment. 61
31076626 2019
42
[A Case of Congenital Syphilis and Prozone Phenomenon]. 61
31414635 2019
43
Attributable fraction of congenital syphilis due to the lack of prenatal care. 61
31340359 2019
44
Congenital syphilis after maternal macrolide therapy in a presumed penicillin allergic patient. Time to change the Chilean governmental normative. 61
31859999 2019
45
NewsCAP: The WHO reports high mortality from congenital syphilis. 61
31135419 2019
46
Rubella virus, Toxoplasma gondii and Treponema pallidum congenital infections among full term delivered women in an urban area of Tanzania: a call for improved antenatal care. 61
31656468 2019
47
A panorama of the health situation in Brazil's Federal District, 2005 to 2017. 61
31269160 2019
48
Molecular detection of Treponema pallidum subspecies pallidum in 150-year-old foetal remains, southeastern France. 61
30994442 2019
49
Congenital Syphilis: A Challenging Case for NICU Clinicians. 61
31470384 2019
50
Diagnostic and Therapeutic Knowledge and Practices in the Management of Congenital Syphilis by Pediatricians in Public Maternity Hospitals in Brazil. 61
28735562 2019

Variations for Congenital Syphilis

Expression for Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for Congenital Syphilis

Pathways related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 PLCE1 NPHS2 NPHS1 MYH9
2 10.71 CD79A CD40LG CD4
3 10.57 NPHS2 NPHS1

GO Terms for Congenital Syphilis

Cellular components related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 slit diaphragm GO:0036057 8.62 NPHS2 NPHS1

Biological processes related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myoblast fusion GO:0007520 8.62 NPHS1 MYH9

Molecular functions related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 TPR MYH9

Sources for Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....