MCID: CNG033
MIFTS: 40

Congenital Syphilis

Categories: Infectious diseases, Fetal diseases, Rare diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Congenital Syphilis

MalaCards integrated aliases for Congenital Syphilis:

Name: Congenital Syphilis 12 76 59 15
Syphilis, Congenital 44 73
Mother-to-Child Transmission of Syphilis 59
Syphilis Congenital 55
Mtct of Syphilis 59

Classifications:



External Ids:

Disease Ontology 12 DOID:9856
ICD10 33 A50 A50.9
ICD9CM 35 090 090.9
MeSH 44 D013590
NCIt 50 C84649
Orphanet 59 ORPHA499009
UMLS 73 C0039131

Summaries for Congenital Syphilis

Disease Ontology : 12 A syphilis that results in a multisystem infection in the fetus via the placenta.

MalaCards based summary : Congenital Syphilis, also known as syphilis, congenital, is related to early congenital syphilis and late congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Congenital Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Penicillin G and penicillins have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and eye.

Wikipedia : 76 Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a... more...

Related Diseases for Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 early congenital syphilis 34.3 CD40LG MYH9
2 late congenital syphilis 34.3 DDX41 EXTL3
3 chorioretinitis 29.6 CD40LG CD79A EXTL3
4 syphilis 28.8 CD40LG CD79A DDX41 EXTL3 MYH9 POLA1
5 primary syphilis 28.3 CD40LG EXTL3 MYH9 POLA1
6 paroxysmal cold hemoglobinuria 11.2
7 selective igg deficiency disease 10.7 CD40LG CD79A
8 c1q nephropathy 10.7 CD40LG CD79A
9 meningovascular neurosyphilis 10.7 CD40LG CD79A
10 alpha chain disease 10.7 CD40LG CD79A
11 brill-zinsser disease 10.7 CD40LG CD79A
12 exudative glomerulonephritis 10.7 CD40LG CD79A
13 cork-handlers' disease 10.7 CD40LG CD79A
14 salpingo-oophoritis 10.7 CD40LG CD79A
15 ventilation pneumonitis 10.7 CD40LG CD79A
16 chronic interstitial cystitis 10.7 CD40LG CD79A
17 axillary adenitis 10.7 CD40LG CD79A
18 cryofibrinogenemia 10.7 CD40LG CD79A
19 trichostrongyloidiasis 10.7 CD40LG CD79A
20 subacute bacterial endocarditis 10.7 CD40LG CD79A
21 heterophyiasis 10.7 CD40LG CD79A
22 immunoglobulin g deficiency 10.7 CD40LG CD79A
23 orbital granuloma 10.7 CD40LG CD79A
24 transient hypogammaglobulinemia of infancy 10.7 CD40LG CD79A
25 hyperglobulinemic purpura 10.7 CD40LG CD79A
26 gastroduodenitis 10.7 CD40LG CD79A
27 bacterial conjunctivitis 10.7 CD40LG CD79A
28 heavy chain disease 10.7 CD40LG CD79A
29 ophthalmia neonatorum 10.7 CD40LG CD79A
30 immunoglobulin a deficiency 1 10.7 CD40LG CD79A
31 parotid disease 10.6 CD40LG CD79A
32 cerebral arteritis 10.6 CD40LG CD79A
33 selective immunoglobulin deficiency disease 10.6 CD40LG CD79A
34 geniculate herpes zoster 10.6 CD40LG CD79A
35 erythema elevatum diutinum 10.6 CD40LG CD79A
36 sporotrichosis 10.6 CD40LG CD79A
37 fallopian tube disease 10.6 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.6 CD40LG CD79A
39 polyclonal hypergammaglobulinemia 10.6 CD40LG CD79A
40 monoclonal paraproteinemia 10.6 CD40LG CD79A
41 salpingitis 10.6 CD40LG CD79A
42 ocular toxoplasmosis 10.6 CD40LG CD79A
43 dysgammaglobulinemia 10.6 CD40LG CD79A
44 congenital hypogammaglobulinemia 10.6 CD40LG CD79A
45 acute maxillary sinusitis 10.6 CD40LG CD79A
46 chronic polyneuropathy 10.6 CD40LG CD79A
47 spinocerebellar ataxia, autosomal recessive 10 10.6 CD40LG CD79A
48 parasitic ichthyosporea infectious disease 10.6 CD40LG CD79A
49 cd40 ligand deficiency 10.6 CD40LG CD79A
50 rhinosporidiosis 10.6 CD40LG CD79A

Graphical network of the top 20 diseases related to Congenital Syphilis:



Diseases related to Congenital Syphilis

Symptoms & Phenotypes for Congenital Syphilis

UMLS symptoms related to Congenital Syphilis:


syphilitic chancre

Drugs & Therapeutics for Congenital Syphilis

Drugs for Congenital Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Not Applicable 61-33-6 5904
2 penicillins Not Applicable
3 Penicillin G Benzathine Not Applicable
4 Penicillin G Procaine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventing Congenital Syphilis Completed NCT02353117 Not Applicable

Search NIH Clinical Center for Congenital Syphilis

Cochrane evidence based reviews: syphilis, congenital

Genetic Tests for Congenital Syphilis

Anatomical Context for Congenital Syphilis

MalaCards organs/tissues related to Congenital Syphilis:

41
Bone, Liver, Eye, Brain, Placenta, Spleen, Testes

Publications for Congenital Syphilis

Articles related to Congenital Syphilis:

(show top 50) (show all 622)
# Title Authors Year
1
The History of Congenital Syphilis Behind The Inheritance by Edvard Munch. ( 29541782 )
2018
2
Use of National Syphilis Surveillance Data to Develop a Congenital Syphilis Prevention Cascade and Estimate the Number of Potential Congenital Syphilis Cases Averted. ( 29543623 )
2018
3
A brief recent history of the epidemiology of congenital syphilis in the United Kingdom. ( 29862901 )
2018
4
A Case of Congenital Syphilis Presenting with Unusual Skin Eruptions. ( 29770234 )
2018
5
Pathways to Congenital Syphilis Prevention: A Rapid Qualitative Assessment of Barriers, and the Public Health Response, in Caddo Parish, Louisiana. ( 29465658 )
2018
6
A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities. ( 29314211 )
2018
7
Congenital syphilis. ( 29627075 )
2018
8
Prevention of Congenital Syphilis Through Antenatal Screenings in Lusaka, Zambia: A Systematic Review. ( 29560291 )
2018
9
Dactylitis as the presenting manifestation of congenital syphilis in an infant. ( 29787466 )
2018
10
Sixth child dies from congenital syphilis in northern Australia. ( 29555652 )
2018
11
Analysis of cases of gestational and congenital syphilis between 2008 and 2010 in Fortaleza, State of CearA!, Brazil. ( 29412414 )
2018
12
Presence of dental signs of congenital syphilis in pre-modern specimens. ( 29102860 )
2018
13
Infectious and congenital syphilis in Canada, 2010-2015. ( 29770098 )
2018
14
High prevalence of syphilis in parturient women and congenital syphilis cases in public maternities in Salvador-Bahia, Brazil. ( 29802689 )
2018
15
Congenital Syphilis Prevention: Strategies, Evidence, and Future Directions. ( 29624562 )
2018
16
Social Vulnerability in Congenital Syphilis Case Mothers: Qualitative Assessment of Cases in Indiana, 2014 to 2016. ( 29465662 )
2018
17
Congenital syphilis as a clinical and histopathologic mimic of neonatal lupus. ( 29943505 )
2018
18
Characteristics Associated With Delivery of an Infant With Congenital Syphilis and Missed Opportunities for Prevention-California, 2012 to 2014. ( 29465666 )
2018
19
The Re-Emergence of Congenital Syphilis in Ohio. ( 29570589 )
2018
20
Congenital syphilis, a public health problem only in Brazil? ( 29878529 )
2018
21
Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. ( 28942420 )
2017
22
Diagnostic and Therapeutic Knowledge and Practices in the Management of Congenital Syphilis by Pediatricians in Public Maternity Hospitals in Brazil. ( 28735562 )
2017
23
Congenital syphilis in England and amendments to the BASHH guideline for management of affected infants. ( 29027897 )
2017
24
Late-onset congenital syphilis with unusual brain abnormalities. ( 28977151 )
2017
25
Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil. ( 29166489 )
2017
26
Dental Traits of Congenital Syphilis Revisited in Dental Outpatient Department (OPD). ( 28342059 )
2017
27
Congenital Syphilis of Bone: A Potential Mimicker of Childhood Histiocytoses. ( 28614210 )
2017
28
Risk of Congenital Syphilis (CS) Following Treatment of Maternal Syphilis: Results of a CS Control Program in China. ( 28444157 )
2017
29
Congenital Syphilis Presenting with Only Nephrotic Syndrome: Reemergence of a Forgotten Disease. ( 28665076 )
2017
30
Educational intervention in Primary Care for the prevention of congenital syphilis. ( 28146181 )
2017
31
Congenital Syphilis: Time for a National Prevention Program. ( 28703732 )
2017
32
Syphilis in pregnancy and congenital syphilis in Palmas, Tocantins State, Brazil, 2007-2014. ( 28492767 )
2017
33
Early Congenital Syphilis: Recognising Symptoms of an Increasingly Prevalent Disease. ( 28821219 )
2017
34
Sensitivity of nPCR for four types of membrane protein DNA and of two pairs of primers for Tpp47 DNA of Treponema pallidum in whole blood of congenital syphilis newborns. ( 28889773 )
2017
35
Congenital Syphilis: The Great Pretender Strikes Back. A Case Report. ( 29084433 )
2017
36
Congenital syphilis in 2 children in a Bolivian prison. ( 29364335 )
2017
37
Congenital Syphilis Masquerading as Leukemia. ( 28845335 )
2017
38
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. ( 29103618 )
2017
39
Barriers and facilitators to the implementation of antenatal syphilis screening and treatment for the prevention of congenital syphilis in the Democratic Republic of Congo and Zambia: results of qualitative formative research. ( 28807019 )
2017
40
Pseudoparalysis of Parrot: A Diagnostic Aid in Congenital Syphilis. ( 28918883 )
2017
41
Effectiveness of Prenatal Screening and Treatment to Prevent Congenital Syphilis, Louisiana and Florida, 2013-2014. ( 28703731 )
2017
42
Congenital syphilis. ( 28626975 )
2017
43
Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis. ( 29233254 )
2017
44
Congenital syphilis with bone lesion: case report. ( 29234661 )
2017
45
Syphilis in Pregnancy and Congenital Syphilis: Reality in a Portuguese Central University Hospital. ( 28609805 )
2017
46
Congenital syphilis in neonates with nonreactive nontreponemal test results. ( 28682315 )
2017
47
Congenital syphilis in the era of decreasing seroprevalence. ( 26776135 )
2016
48
Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. ( 27443780 )
2016
49
Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La RAcunion, 2008 to 2014. ( 27711044 )
2016
50
Eliminating congenital syphilis-lessons learnt in the United Kingdom should inform global strategy. ( 27102071 )
2016

Variations for Congenital Syphilis

Expression for Congenital Syphilis

Search GEO for disease gene expression data for Congenital Syphilis.

Pathways for Congenital Syphilis

Pathways related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Congenital Syphilis

Biological processes related to Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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