MCID: CNG133
MIFTS: 28

Congenital Varicella Syndrome

Categories: Eye diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Congenital Varicella Syndrome

MalaCards integrated aliases for Congenital Varicella Syndrome:

Name: Congenital Varicella Syndrome 52 58 71
Mother-to-Child Transmission of Varicella Syndrome 58
Fetal Effects of Varicella Zoster Virus 52
Varicella Virus Antenatal Infection 52
Antenatal Varicella Virus Infection 58
Fetal Varicella Zoster Syndrome 52
Fetal Effects of Chickenpox 52
Fetal Varicella Infection 52
Varicella Embryopathy 52

Characteristics:

Orphanet epidemiological data:

58
congenital varicella syndrome
Inheritance: Not applicable; Age of onset: Antenatal,Neonatal;

Classifications:

Orphanet: 58  
Rare eye diseases
Developmental anomalies during embryogenesis
Teratologic disorders
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 P35.8
Orphanet 58 ORPHA291
UMLS 71 C0343560

Summaries for Congenital Varicella Syndrome

NIH Rare Diseases : 52 Congenital varicella syndrome is an extremely rare disorder in which affected infants have distinctive abnormalities at birth due to the mother's infection with chickenpox (maternal varicella zoster) early during pregnancy (i.e., up to 20 weeks gestation). Affected newborns may have a low birth weight and characteristic abnormalities of the skin, brain, eyes, the arms, legs, hands, and/or feet, and/or, in rare cases, other areas of the body. The range and severity of associated symptoms and physical findings may vary greatly from case to case depending upon when maternal varicella zoster infection occurred during fetal development.

MalaCards based summary : Congenital Varicella Syndrome, also known as mother-to-child transmission of varicella syndrome, is related to chickenpox and horner's syndrome. Affiliated tissues include skin, brain and eye, and related phenotypes are intrauterine growth retardation and atypical scarring of skin

Wikipedia : 74 Chickenpox, also known as varicella, is a highly contagious disease caused by the initial infection with... more...

Related Diseases for Congenital Varicella Syndrome

Diseases in the Varicella, Severe Recurrent family:

Congenital Varicella Syndrome

Diseases related to Congenital Varicella Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 chickenpox 10.7
2 horner's syndrome 10.1
3 herpes zoster 10.1
4 exanthem 10.0
5 eye disease 10.0
6 bronchopneumonia 10.0
7 toxoplasmosis 9.9
8 anisocoria 9.8
9 heterochromia iridis 9.8
10 vesicoureteral reflux 1 9.8
11 hydrocephalus, congenital, 1 9.8
12 aspiration pneumonia 9.8
13 porencephaly 9.8
14 persistent hyperplastic primary vitreous 9.8
15 microphthalmia 9.8
16 chronic pyelonephritis 9.8
17 microcephaly 9.8
18 hydrocephalus 9.8
19 chorioretinal scar 9.8
20 respiratory failure 9.8
21 pyelonephritis 9.8
22 hypertensive heart disease 9.8
23 clubfoot 9.8
24 neurogenic bladder 9.8
25 acute cystitis 9.8
26 congenital toxoplasmosis 9.8
27 constipation 9.8
28 focal epilepsy 9.8
29 radiculopathy 9.8
30 congestive heart failure 9.8
31 paraplegia 9.8
32 muscular atrophy 9.8
33 chorioretinitis 9.8
34 bronchopulmonary dysplasia 9.8
35 neonatal herpes 9.8
36 dysphagia 9.8
37 encephalopathy 9.8
38 renal dysplasia 9.8

Graphical network of the top 20 diseases related to Congenital Varicella Syndrome:



Diseases related to Congenital Varicella Syndrome

Symptoms & Phenotypes for Congenital Varicella Syndrome

Human phenotypes related to Congenital Varicella Syndrome:

58 31 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intrauterine growth retardation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001511
2 atypical scarring of skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0000987
3 intellectual disability 58 31 frequent (33%) Frequent (79-30%) HP:0001249
4 cataract 58 31 frequent (33%) Frequent (79-30%) HP:0000518
5 global developmental delay 58 31 frequent (33%) Frequent (79-30%) HP:0001263
6 cerebral cortical atrophy 58 31 frequent (33%) Frequent (79-30%) HP:0002120
7 microcephaly 58 31 frequent (33%) Frequent (79-30%) HP:0000252
8 micromelia 58 31 frequent (33%) Frequent (79-30%) HP:0002983
9 microphthalmia 58 31 frequent (33%) Frequent (79-30%) HP:0000568

Drugs & Therapeutics for Congenital Varicella Syndrome

Search Clinical Trials , NIH Clinical Center for Congenital Varicella Syndrome

Genetic Tests for Congenital Varicella Syndrome

Anatomical Context for Congenital Varicella Syndrome

MalaCards organs/tissues related to Congenital Varicella Syndrome:

40
Skin, Brain, Eye, Heart, Spinal Cord, Colon, Testes

Publications for Congenital Varicella Syndrome

Articles related to Congenital Varicella Syndrome:

(show top 50) (show all 117)
# Title Authors PMID Year
1
Epidemiology, management and outcome of varicella in pregnancy: a 20-year experience at the Tuscany Reference Centre for Infectious Diseases in Pregnancy. 61
29766472 2018
2
Birth palsy in congenital varicella syndrome: A lesson in anatomy. 61
30505098 2018
3
Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn. 61
29492329 2018
4
Isolated lower limb hypoplasia secondary to congenital varicella syndrome: a rare occurrence and management of its complications. 61
28331020 2017
5
Common Skin Conditions in Children: Neonatal Skin Lesions. 61
28196316 2017
6
Microbiology laboratory and the management of mother-child varicella-zoster virus infection. 61
27563537 2016
7
Congenital varicella syndrome: A systematic review. 61
26965725 2016
8
Congenital Varicella Syndrome. 61
27029702 2016
9
Management of varicella-zoster virus primary infection during pregnancy: A national survey of practice. 61
26356985 2015
10
Closure of varicella-zoster virus-containing vaccines pregnancy registry - United States, 2013. 61
25144545 2014
11
[Varicella-zoster virus and pregnancy]. 61
24863663 2014
12
Congenital varicella syndrome in a monochorionic diamniotic twin pregnancy. 61
25097633 2014
13
[Congenital varicella syndrome and neonatal herpes zoster]. 61
23747072 2013
14
The role of VariZIG in pregnancy. 61
24093779 2013
15
Varicella vaccination in Japan: necessity of implementing a routine vaccination program. 61
23483311 2013
16
Seroprevalence of cytomegalovirus, Epstein Barr virus and varicella zoster virus among pregnant women in Bradford: a cohort study. 61
24312372 2013
17
Varicella-zoster virus: Prevention through vaccination. 61
22510639 2012
18
Prenatal sonographic diagnosis of congenital varicella syndrome. 61
22323269 2012
19
Anesthetic implications of two genetic translocation (6p21; 6p13) in a patient with history of congenital varicella syndrome: a case report. 61
22788083 2012
20
Varicella-zoster virus (chickenpox) infection in pregnancy. 61
21585641 2011
21
Congenital varicella syndrome in a very low birthweight preterm infant. 61
21138830 2011
22
[Varicella during pregnancy: consequences for the mother and the newborn]. 61
21674893 2011
23
The prevalence of congenital varicella syndrome after a maternal infection, but before 20 weeks of pregnancy: a prospective cohort study. 61
20670093 2011
24
Preventing congenital varicella syndrome with immunization. 61
21262940 2011
25
Congenital varicella syndrome: the evidence for secondary prevention with varicella-zoster immune globulin. 61
21262937 2011
26
Causes of neonatal brachial plexus palsy. 61
21332434 2011
27
[Skin infections in pregnancy]. 61
21079901 2010
28
Congenital varicella syndrome/vericella zoster virus (VZV) fetopathy. 61
19936656 2010
29
Varicella in the fetus and newborn. 61
19097954 2009
30
Congenital varicella syndrome: still a problem? 61
19478488 2009
31
Unilateral laryngeal paralysis in a newborn with congenital varicella syndrome. 61
19054581 2009
32
Genotypes of varicella-zoster virus wild-type strains in Germany. 61
18428135 2008
33
Varicella vaccine exposure during pregnancy: data from 10 Years of the pregnancy registry. 61
18419394 2008
34
Varicella-related deaths in children and adolescents--Germany 2003-2004. 61
18076716 2008
35
Varicella and the pregnant woman: prevention and management. 61
18275568 2008
36
Chronic varicella-zoster skin infection complicating the congenital varicella syndrome. 61
17845179 2007
37
Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: Varicella-zoster virus infections. 61
17180380 2007
38
[Varicella during pregnancy and in neonates]. 61
17225984 2007
39
Recurrent hemiplegia associated with cerebral vasculopathy following third trimester maternal herpes zoster infection. 61
17109789 2006
40
Congenital varicella syndrome: presenting with eye complications. 61
16891691 2006
41
Chickenpox in pregnancy: revisited. 61
15979274 2006
42
[Infections with herpes simplex and varicella-zoster viruses during pregnancy]. 61
16514526 2006
43
Prenatal ultrasound diagnosis, follow-up, and outcome of congenital varicella syndrome. 61
16601342 2006
44
Microphthalmia due to congenital varicella infection: a case report. 61
16402016 2005
45
Congenital varicella syndrome in the third trimester. 61
16271630 2005
46
Distribution of varicella-zoster virus DNA and gene products in tissues of a first-trimester varicella-infected fetus. 61
15655777 2005
47
Genitourinary anomaly in congenital varicella syndrome. 61
15221427 2004
48
Alphafoetoprotein and acetylcholinesterase in amniotic fluid as a factor suggesting fetal skin and nerve lesions in a case of congenital varicella syndrome. 61
15300737 2004
49
Congenital varicella syndrome. 61
15346925 2004
50
Genitourinary anomaly in congenital varicella syndrome: case report and review. 61
15015072 2004

Variations for Congenital Varicella Syndrome

Expression for Congenital Varicella Syndrome

Search GEO for disease gene expression data for Congenital Varicella Syndrome.

Pathways for Congenital Varicella Syndrome

GO Terms for Congenital Varicella Syndrome

Sources for Congenital Varicella Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....