MCID: CNJ001
MIFTS: 29

Conjugate Gaze Palsy

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Conjugate Gaze Palsy

MalaCards integrated aliases for Conjugate Gaze Palsy:

Name: Conjugate Gaze Palsy 12 52 15
Palsy of Conjugate Gaze 12 71 32
Supranuclear Ocular Palsy 52
Gaze Palsy 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12445
ICD9CM 34 378.81
SNOMED-CT 67 1534008
ICD10 32 H51.0
UMLS 71 C0702143

Summaries for Conjugate Gaze Palsy

MalaCards based summary : Conjugate Gaze Palsy, also known as palsy of conjugate gaze, is related to horizontal gaze palsy with progressive scoliosis and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset, and has symptoms including spasm of conjugate gaze and anomalies of divergence. An important gene associated with Conjugate Gaze Palsy is PLAA (Phospholipase A2 Activating Protein). The drugs Rivastigmine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and myeloid.

Wikipedia : 74 Conjugate gaze palsies are neurological disorders affecting the ability to move both eyes in the same... more...

Related Diseases for Conjugate Gaze Palsy

Diseases related to Conjugate Gaze Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 horizontal gaze palsy with progressive scoliosis 12.9
2 neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset 12.9
3 gaze palsy, familial horizontal, with progressive scoliosis 1 12.9
4 arthrogryposis, perthes disease, and upward gaze palsy 12.9
5 gaze palsy, familial horizontal, with progressive scoliosis 2, with impaired intellectual development 12.8
6 supranuclear palsy, progressive, 1 11.9
7 kufor-rakeb syndrome 11.9
8 dementia, lewy body 11.7
9 spastic ataxia 1, autosomal dominant 11.6
10 gaucher disease, type iii 11.6
11 niemann-pick disease, type c1 11.6
12 niemann-pick disease, type c2 11.6
13 niemann-pick disease 11.6
14 agenesis of the corpus callosum with peripheral neuropathy 11.4
15 rhyns syndrome 11.4
16 medulloblastoma 11.3
17 papilloma of choroid plexus 11.3
18 athabaskan brainstem dysgenesis syndrome 11.3
19 spinocerebellar ataxia 15 11.3
20 spastic paraplegia 35, autosomal recessive 11.3
21 parkinson disease 14, autosomal recessive 11.3
22 polr3-related leukodystrophy 11.3
23 frontotemporal dementia with parkinsonism-17 11.3
24 ataxia and polyneuropathy, adult-onset 10.6
25 pathologic nystagmus 10.6
26 kearns-sayre syndrome 10.5
27 ptosis 10.4
28 internuclear ophthalmoplegia 10.4
29 apraxia 10.3
30 monocular esotropia 10.3
31 esotropia 10.3
32 dysphagia 10.3
33 tremor 10.3
34 frontotemporal dementia 10.3
35 corticobasal degeneration 10.3
36 encephalopathy 10.3
37 gaucher's disease 10.2
38 lateral sclerosis 10.2
39 motor neuron disease 10.2
40 encephalitis 10.2
41 myoclonus 10.2
42 amyotrophic lateral sclerosis 1 10.2
43 aphasia 10.2
44 alternating exotropia 10.2
45 exotropia 10.2
46 dementia 10.2
47 movement disease 10.2
48 dystonia 10.2
49 abducens palsy 10.1
50 multiple sclerosis 10.1

Graphical network of the top 20 diseases related to Conjugate Gaze Palsy:



Diseases related to Conjugate Gaze Palsy

Symptoms & Phenotypes for Conjugate Gaze Palsy

UMLS symptoms related to Conjugate Gaze Palsy:


spasm of conjugate gaze, anomalies of divergence

Drugs & Therapeutics for Conjugate Gaze Palsy

Drugs for Conjugate Gaze Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivastigmine Approved, Investigational Phase 3 123441-03-2 77991
2 Cholinergic Agents Phase 3
3 Neuroprotective Agents Phase 3
4 Cholinesterase Inhibitors Phase 3
5 Neurotransmitter Agents Phase 3
6
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
7
Cysteine Approved, Nutraceutical Phase 1, Phase 2 52-90-4 5862
8 Protective Agents Phase 1, Phase 2
9 Anti-Infective Agents Phase 1, Phase 2
10 Respiratory System Agents Phase 1, Phase 2
11 Antidotes Phase 1, Phase 2
12 Antioxidants Phase 1, Phase 2
13 Antiviral Agents Phase 1, Phase 2
14 Expectorants Phase 1, Phase 2
15 N-monoacetylcystine Phase 1, Phase 2
16
Nicotinamide Approved, Investigational 98-92-0 936
17
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
18
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
19
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
20 Micronutrients
21 Vitamins
22 Trace Elements
23 Vitamin B Complex
24 Nicotinic Acids
25 Vitamin B3
26 Vasodilator Agents
27 Folate
28 Nutrients
29 Lipid Regulating Agents
30 pyruvate
31 Hypolipidemic Agents
32 Vitamin B9
33 Antimetabolites
34
Bilirubin 69853-43-6, 635-65-4 21252250 5280352

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 RIVA-PSP: Efficacy of Rivastigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy: A Randomised Double Blind Placebo-controlled Clinical Trial Unknown status NCT02839642 Phase 3 Rivastigmine;Placebo
2 Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine Completed NCT00975689 Phase 1, Phase 2 N-Acetyl Cysteine
3 Functional Assessment of the Melanopsin-Containing Retinal Ganglion Cells in Progressive Supranuclear Palsy Using Chromatic Pupillometry Unknown status NCT03330353
4 The Role of the Neuropsychological Evaluation for Early Diagnosis of Progressive Supranuclear Palsy Completed NCT03478124
5 Longitudinal Study of Cognition With Niemann-Pick Disease, Type C Completed NCT01899950
6 Clinical and Biochemical Effects of Macrophage-Targeted Glucocerebrosidase on Neurological Involvement in Neuronopathic Gaucher's Disease Completed NCT00001289
7 Energy Metabolism in Neurodegenerative Diseases: A Randomized, Double Blind, Placebo-Controlled Clinical Pilot Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy. Completed NCT00605930
8 Induced Pluripotent Stem Cells for the Development of Novel Drug Therapies for Hepatic and Neurological Niemann Pick Disease Completed NCT03883750
9 A Randomized Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus. Results of the Dutch Evaluation Program Strata Shunt (DEPSS) Trial Completed NCT01570257
10 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
11 Development of a Neonatal Jaundice Treatment Accelerator by Redirection of Unused Light During Phototherapy Recruiting NCT04021927
12 Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C Recruiting NCT00344331
13 TReatment Strategy In Acute Ischemic larGE Vessel STROKE: Prioritize Thrombolysis or Endovascular Treatment Recruiting NCT03542188
14 Biomarker for Niemann Pick Type C Disease (NPC1/NPC2) an International, Multicenter, Epidemiological Study Active, not recruiting NCT01306604

Search NIH Clinical Center for Conjugate Gaze Palsy

Genetic Tests for Conjugate Gaze Palsy

Anatomical Context for Conjugate Gaze Palsy

MalaCards organs/tissues related to Conjugate Gaze Palsy:

40
Eye, Brain, Myeloid, Pons

Publications for Conjugate Gaze Palsy

Articles related to Conjugate Gaze Palsy:

(show all 25)
# Title Authors PMID Year
1
Fisher one-and-a-half syndrome due to a bulb protuberance cavernoma. 61
30455115 2019
2
Bilateral Internuclear Ophthalmoplegia in a Young Woman with Vertebral Artery Dissection. 61
31293990 2019
3
Vertical muscle transposition with silicone band belting in VI nerve palsy. 61
27974341 2016
4
Surgical planning and innervation in pontine gaze palsy with ipsilateral esotropia. 61
27651233 2016
5
Raymond syndrome and conjugate gaze palsy from a paramedian pontine infarct. 61
26215110 2015
6
Middle cerebral artery infarct following multiple bee stings. 61
20702115 2012
7
Pontine warning syndrome. 61
18852355 2008
8
Acute myeloid leukemia presenting as one-and-a-half syndrome. 61
18410825 2008
9
The clinical syndrome and etiological mechanism of infarction involving the nucleus prepositus hypoglossi. 61
18628616 2008
10
A small dorsal pontine infarction presenting with total gaze palsy including vertical saccades and pursuit. 61
19513135 2007
11
[A case of pontine infarction presenting with conjugate deviation and unilateral conjugate gaze palsy]. 61
17585606 2007
12
Isolated brain stem tuberculoma presenting with one and a half syndrome. 61
16951784 2006
13
Is this patient having a stroke? 61
15900010 2005
14
Two siblings with familial idiopathic scoliosis with conjugate gaze palsy. 61
15791929 2005
15
Isolated conjugate gaze palsy after frontal lobe tumour surgery. 61
15799198 2004
16
Case report: one-and-a-half-syndrome and tuberculosis of the pons in a patient with AIDS. 61
11051628 2000
17
Horizontal conjugate gaze palsy in eosinophilic meningitis. 61
10774676 1999
18
Unilateral conjugate gaze palsy due to a lesion of the abducens nucleus. Clinical and neuroradiological correlations. 61
8501264 1993
19
Nuclear and infranuclear disorders. 61
1344077 1992
20
Neuro-ophthalmic findings in acquired immunodeficiency syndrome. 61
2168900 1990
21
Abnormalities of horizontal gaze. Clinical, oculographic and magnetic resonance imaging findings. I. Abducens palsy. 61
2324751 1990
22
Brainstem ocular motility defects and AIDS. 61
3177562 1988
23
Dissociated ipsilateral horizontal gaze palsy in one-and-a-half syndrome: a clinicopathologic study. 61
3399079 1988
24
The one-and-a-half syndrome--a unilateral disorder of the pontine tegmentum: a study of 20 cases and review of the literature. 61
6683820 1983
25
Lateral tegmental brainstem hemorrhages. 61
7199635 1982

Variations for Conjugate Gaze Palsy

Expression for Conjugate Gaze Palsy

Search GEO for disease gene expression data for Conjugate Gaze Palsy.

Pathways for Conjugate Gaze Palsy

GO Terms for Conjugate Gaze Palsy

Cellular components related to Conjugate Gaze Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain GO:0070469 8.62 UQCRC2 NDUFB8

Sources for Conjugate Gaze Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....