MCID: CNJ001
MIFTS: 30

Conjugate Gaze Palsy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Conjugate Gaze Palsy

MalaCards integrated aliases for Conjugate Gaze Palsy:

Name: Conjugate Gaze Palsy 12 15
Palsy of Conjugate Gaze 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12445
ICD9CM 36 378.81
SNOMED-CT 69 1534008
ICD10 34 H51.0
UMLS 74 C0702143

Summaries for Conjugate Gaze Palsy

MalaCards based summary : Conjugate Gaze Palsy, also known as palsy of conjugate gaze, is related to supranuclear ocular palsy and scoliosis, and has symptoms including spasm of conjugate gaze and anomalies of divergence. An important gene associated with Conjugate Gaze Palsy is LARS (Leucyl-TRNA Synthetase), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Rivastigmine and Cholinesterase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Conjugate gaze palsies are neurological disorders affecting the ability to move both eyes in the same... more...

Related Diseases for Conjugate Gaze Palsy

Graphical network of the top 20 diseases related to Conjugate Gaze Palsy:



Diseases related to Conjugate Gaze Palsy

Symptoms & Phenotypes for Conjugate Gaze Palsy

UMLS symptoms related to Conjugate Gaze Palsy:


spasm of conjugate gaze, anomalies of divergence

GenomeRNAi Phenotypes related to Conjugate Gaze Palsy according to GeneCards Suite gene sharing:

27 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.81 F3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.81 LARS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.81 F3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.81 LARS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.81 LARS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.81 F3 LARS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.81 F3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.81 LARS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.73 LARS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.73 F3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.73 F3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.73 F3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.73 LARS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.73 F3 LARS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.73 LARS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.73 LARS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.73 F3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.73 F3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.73 LARS
20 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.62 LARS PLG

Drugs & Therapeutics for Conjugate Gaze Palsy

Drugs for Conjugate Gaze Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivastigmine Approved, Investigational Phase 3 123441-03-2 77991
2 Cholinesterase Inhibitors Phase 3
3 Protective Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Cholinergic Agents Phase 3
6 Neuroprotective Agents Phase 3
7
Ethanol Approved 64-17-5 702
8
2-Phenylethanol Experimental 60-12-8 6054

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy Recruiting NCT02839642 Phase 3 Rivastigmine;Placebo
2 Longitudinal Study of Cognition With Niemann-Pick Disease, Type C Completed NCT01899950
3 Effects of Enzyme Replacement in Gaucher's Disease Completed NCT00001289
4 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
5 Biomarkers in Neural Disorders Active, not recruiting NCT02761707

Search NIH Clinical Center for Conjugate Gaze Palsy

Genetic Tests for Conjugate Gaze Palsy

Anatomical Context for Conjugate Gaze Palsy

MalaCards organs/tissues related to Conjugate Gaze Palsy:

42
Eye

Publications for Conjugate Gaze Palsy

Articles related to Conjugate Gaze Palsy:

# Title Authors Year
1
Raymond syndrome and conjugate gaze palsy from a paramedian pontine infarct. ( 26215110 )
2015
2
Two siblings with familial idiopathic scoliosis with conjugate gaze palsy. ( 15791929 )
2005
3
Isolated conjugate gaze palsy after frontal lobe tumour surgery. ( 15799198 )
2004
4
Horizontal conjugate gaze palsy in eosinophilic meningitis. ( 10774676 )
1999
5
Unilateral conjugate gaze palsy due to a lesion of the abducens nucleus. Clinical and neuroradiological correlations. ( 8501264 )
1993

Variations for Conjugate Gaze Palsy

Expression for Conjugate Gaze Palsy

Search GEO for disease gene expression data for Conjugate Gaze Palsy.

Pathways for Conjugate Gaze Palsy

GO Terms for Conjugate Gaze Palsy

Cellular components related to Conjugate Gaze Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.62 F3 PLG

Biological processes related to Conjugate Gaze Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 8.96 F3 PLG
2 hemostasis GO:0007599 8.62 F3 PLG

Molecular functions related to Conjugate Gaze Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.62 F3 PLG

Sources for Conjugate Gaze Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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