MCID: CNJ009
MIFTS: 33

Conjunctival Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Conjunctival Cancer

MalaCards integrated aliases for Conjunctival Cancer:

Name: Conjunctival Cancer 12 15
Malignant Neoplasm of Conjunctiva 12 71
Conjunctival Neoplasms 44 71
Malignant Tumor of Conjunctiva 12
Malignant Conjunctival Tumor 12
Neoplasm of Conjunctiva 12
Conjunctival Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5467
ICD9CM 34 190.3
MeSH 44 D003230
NCIt 50 C2961 C3564
SNOMED-CT 67 126996004 93764002
ICD10 32 C69.0
UMLS 71 C0009761 C0153628

Summaries for Conjunctival Cancer

MalaCards based summary : Conjunctival Cancer, also known as malignant neoplasm of conjunctiva, is related to conjunctival squamous cell carcinoma and hemangioma. An important gene associated with Conjunctival Cancer is MIR518A1 (MicroRNA 518a-1), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Human cytomegalovirus infection. The drugs Lenalidomide and Sunitinib have been mentioned in the context of this disorder. Affiliated tissues include eye and brain.

Related Diseases for Conjunctival Cancer

Diseases related to Conjunctival Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 conjunctival squamous cell carcinoma 31.8 KRT12 IFNA2
2 hemangioma 29.5 IFNA2 GNAQ GNA11
3 conjunctival nevus 29.2 NRAS MLANA HRAS GNAQ
4 skin carcinoma 28.8 NRAS MLANA IFNA2 HRAS GNAQ GNA11
5 melanoma 28.5 NRAS MLANA MIR302D IFNA2 HRAS GNAQ
6 malignant conjunctival melanoma 25.9 NRAS MLANA MIR8078 MIR6084 MIR518A1 MIR501
7 primary lymphoma of the conjunctiva 11.1
8 conjunctival pigmentation 10.3 MLANA IFNA2
9 ovarian melanoma 10.3 NRAS MLANA
10 sensory organ benign neoplasm 10.3 NRAS MLANA
11 phakomatosis cesioflammea 10.3 GNAQ GNA11
12 epithelioid cell melanoma 10.3 MLANA GNA11
13 hypocalciuric hypercalcemia, familial, type ii 10.2 GNAQ GNA11
14 pseudopterygium 10.2 KRT12 IFNA2
15 melanomatosis 10.2 NRAS MLANA GNAQ
16 meningeal melanocytoma 10.1 MLANA GNAQ GNA11
17 hypomelanosis of ito 10.1 NRAS GNAQ GNA11
18 weber syndrome 10.1 GNAQ GNA11
19 mongolian spot 10.1 MLANA GNAQ GNA11
20 ocular melanoma 10.1 NRAS GNAQ GNA11
21 ocular cancer 10.1 MLANA GNAQ GNA11
22 meningeal melanoma 10.0 NRAS MLANA GNAQ GNA11
23 orbit rhabdomyosarcoma 10.0 NRAS MLANA IFNA2 GNAQ
24 malignant leptomeningeal tumor 10.0 NRAS MLANA GNAQ GNA11
25 mucosal melanoma 10.0 NRAS IFNA2 GNAQ GNA11
26 acneiform dermatitis 10.0 NRAS HRAS
27 core binding factor acute myeloid leukemia 9.9 NRAS HRAS
28 oculoectodermal syndrome 9.9 NRAS HRAS
29 large intestine adenocarcinoma 9.9 NRAS HRAS
30 nasal cavity adenocarcinoma 9.9 MLANA HRAS
31 melanocytic nevus syndrome, congenital 9.9 NRAS HRAS
32 benign struma ovarii 9.8 NRAS HRAS
33 nevus, epidermal 9.8 NRAS HRAS GNAQ
34 chronic conjunctivitis 9.8
35 sebaceous adenocarcinoma 9.8
36 primary malignant melanoma of the conjunctiva 9.8
37 nasal cavity cancer 9.8 MLANA HRAS
38 vulvar disease 9.8 NRAS HRAS
39 keratitis, hereditary 9.8
40 salivary gland carcinoma 9.8
41 squamous cell papilloma 9.8
42 squamous cell carcinoma 9.8
43 papilloma 9.8
44 eyelid carcinoma 9.8
45 bowen's disease 9.8
46 rare tumor 9.8
47 pfeiffer syndrome 9.8
48 lymphoma, mucosa-associated lymphoid type 9.8
49 kaposi sarcoma 9.8
50 celiac disease 1 9.8

Graphical network of the top 20 diseases related to Conjunctival Cancer:



Diseases related to Conjunctival Cancer

Symptoms & Phenotypes for Conjunctival Cancer

Drugs & Therapeutics for Conjunctival Cancer

Drugs for Conjunctival Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
3
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
4 Angiogenesis Inhibitors Phase 2
5 Immunologic Factors Phase 2
6 Immunosuppressive Agents Phase 2
7 Antirheumatic Agents Phase 2
8 Protein Kinase Inhibitors Phase 2
9 Alkylating Agents Phase 2
10
Ranibizumab Approved Phase 1 347396-82-1 459903
11
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
12 Molgramostim Investigational Phase 1 99283-10-0
13 Vaccines Phase 1
14 Freund's Adjuvant Phase 1
15 Adjuvants, Immunologic Phase 1
16 CPG-oligonucleotide Phase 1
17 Fibrin Tissue Adhesive
18 Mitomycins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Combination Oral CC-5013 Lenalidomide (Revlimid™), Oral Sunitinib (Sutent™) and Low Dose Oral Metronomic Cyclophosphamide for the Treatment of Stage IV Ocular Melanoma Terminated NCT00482911 Phase 2 cyclophosphamide;lenalidomide;sunitinib malate
2 Effect of Ranibizumab on Malignant Conjunctival Neoplasia Completed NCT00456495 Phase 1 ranibizumab
3 A Multipeptide Vaccine in Melanoma Patients With Evaluation of the Injection Site Microenvironment Completed NCT00705640 Phase 1
4 Safety and Immunogenicity of Vaccination With Multi-Epitope Peptide Vaccine Containing MART-1, gp100, and Tyrosinase Peptides Given With the Combination of GMCSF and CpG Oligonucleotide (CpG 7909) in ISA-Oil Adjuvant for Patients With Recurrent Inoperable Stage III or Stage IV Melanoma Completed NCT00471471 Phase 1
5 Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Treatment of Diffuse Conjunctival Squamous Cell Carcinoma (CSCC) With Excision, Amniotic Membrane Graft Using Fibrin Glue and Topical Mitomycin C (MMC) Completed NCT03515954

Search NIH Clinical Center for Conjunctival Cancer

Cochrane evidence based reviews: conjunctival neoplasms

Genetic Tests for Conjunctival Cancer

Anatomical Context for Conjunctival Cancer

MalaCards organs/tissues related to Conjunctival Cancer:

40
Eye, Brain

Publications for Conjunctival Cancer

Articles related to Conjunctival Cancer:

(show all 17)
# Title Authors PMID Year
1
Immunodeficiency and Cancer in 3.5 Million People Living with Human Immunodeficiency Virus: the South African HIV Cancer Match Study. 61
33530095 2021
2
Conjunctival cancer in people living with HIV. 61
33337616 2021
3
Epidemiological Analysis and Prognosis of Conjunctival Cancer in the Past Twenty Years: A Population-Based Retrospective Study Using SEER Data. 61
32724792 2020
4
The burden of cancers associated with HIV in the South African public health sector, 2004-2014: a record linkage study. 61
31073325 2019
5
Phase I/II study on kilovoltage surface brachytherapy in conjunctival cancer: preliminary results. 61
29910832 2018
6
Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa. 61
20639761 2010
7
HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma. 61
20498858 2010
8
Postoperative adjuvant external-beam radiation therapy for cancers of the eyelid and conjunctiva. 61
19033839 2008
9
Update on non-acquired immunodeficiency syndrome-defining malignancies. 61
12960522 2003
10
The epidemiology of conjunctival squamous cell carcinoma in Uganda. 61
12177799 2002
11
Update: cancer risk in persons with HIV/AIDS in the era of combination antiretroviral therapy. 61
10881365 2000
12
[TNM classification of ophthalmic malignant tumors]. 61
9679589 1998
13
Epidemiology of squamous cell conjunctival cancer. 61
9037556 1997
14
[A case of invasive corneal and conjunctival cancer]. 61
9577119 1997
15
[Cryotherapy of conjunctival cancer (report of 7 cases) (author's transl)]. 61
6802609 1981
16
[A case of conjunctival cancer; malignant invasion of Bowen's disease]. 61
5815635 1969
17
[Radio-surgical therapy of primary conjunctival cancer]. 61
13299830 1955

Variations for Conjunctival Cancer

Expression for Conjunctival Cancer

Search GEO for disease gene expression data for Conjunctival Cancer.

Pathways for Conjunctival Cancer

Pathways related to Conjunctival Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 NRAS IFNA2 HRAS GNAQ GNA11
2
Show member pathways
12.69 NRAS IFNA2 HRAS GNAQ GNA11
3
Show member pathways
12.66 NRAS HRAS GNAQ GNA11
4 12.56 NRAS IFNA2 HRAS GNAQ GNA11
5
Show member pathways
12.41 NRAS HRAS GNAQ GNA11
6
Show member pathways
12.36 NRAS KRT12 HRAS GNAQ GNA11
7
Show member pathways
12.22 NRAS HRAS GNAQ GNA11
8 11.92 NRAS HRAS GNAQ
9
Show member pathways
11.86 HRAS GNAQ GNA11
10
Show member pathways
11.84 HRAS GNAQ GNA11
11 11.83 NRAS HRAS GNAQ
12 11.8 NRAS HRAS GNAQ
13 11.79 NRAS HRAS GNAQ
14
Show member pathways
11.75 NRAS HRAS GNAQ
15
Show member pathways
11.73 NRAS HRAS GNAQ GNA11
16 11.5 NRAS HRAS GNAQ GNA11
17 11.4 NRAS HRAS GNAQ GNA11
18 11.39 HRAS GNAQ GNA11
19 11.06 NRAS HRAS GNAQ GNA11
20
Show member pathways
11.04 NRAS HRAS
21 10.98 NRAS HRAS
22 10.95 NRAS HRAS
23
Show member pathways
10.75 GNAQ GNA11
24 10.73 NRAS HRAS GNAQ
25 10.7 NRAS HRAS GNAQ GNA11
26 10.59 NRAS HRAS

GO Terms for Conjunctival Cancer

Biological processes related to Conjunctival Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 action potential GO:0001508 9.26 GNAQ GNA11
2 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 GNAQ GNA11
3 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
4 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Conjunctival Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.62 NRAS HRAS GNAQ GNA11
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.26 GNAQ GNA11
3 GTPase activity GO:0003924 9.26 NRAS HRAS GNAQ GNA11
4 guanyl nucleotide binding GO:0019001 9.16 GNAQ GNA11
5 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Conjunctival Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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