MCID: CNJ010
MIFTS: 24

Conjunctival Degeneration

Categories: Eye diseases

Aliases & Classifications for Conjunctival Degeneration

MalaCards integrated aliases for Conjunctival Degeneration:

Name: Conjunctival Degeneration 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10139
ICD10 33 H11.10
ICD9CM 35 372.50
SNOMED-CT 68 193886006 40787005
UMLS 73 C0155160

Summaries for Conjunctival Degeneration

MalaCards based summary : Conjunctival Degeneration is related to pinguecula and iris disease. An important gene associated with Conjunctival Degeneration is XPO4 (Exportin 4), and among its related pathways/superpathways are Acetaminophen Pathway (therapeutic doses), Pharmacokinetics and Nuclear Receptors in Lipid Metabolism and Toxicity. Affiliated tissues include eye, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Conjunctival Degeneration

Graphical network of the top 20 diseases related to Conjunctival Degeneration:



Diseases related to Conjunctival Degeneration

Symptoms & Phenotypes for Conjunctival Degeneration

MGI Mouse Phenotypes related to Conjunctival Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.87 TGM2 TP53 CYP1A1 XPA DCLRE1C ITGB1
2 hematopoietic system MP:0005397 9.86 TGM2 TP53 CD68 CYP1A1 XPA DCLRE1C
3 immune system MP:0005387 9.85 TP53 CD68 XPA CYP1A1 DCLRE1C DHX9
4 neoplasm MP:0002006 9.43 TP53 XPA CYP2E1 ITGB1 PAX6 TGM2
5 pigmentation MP:0001186 8.92 TP53 XPA ITGB1 PAX6

Drugs & Therapeutics for Conjunctival Degeneration

Search Clinical Trials , NIH Clinical Center for Conjunctival Degeneration

Genetic Tests for Conjunctival Degeneration

Anatomical Context for Conjunctival Degeneration

MalaCards organs/tissues related to Conjunctival Degeneration:

41
Eye

Publications for Conjunctival Degeneration

Articles related to Conjunctival Degeneration:

# Title Authors Year
1
Dietary I+-lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects. ( 23989186 )
2013

Variations for Conjunctival Degeneration

Expression for Conjunctival Degeneration

Search GEO for disease gene expression data for Conjunctival Degeneration.

Pathways for Conjunctival Degeneration

GO Terms for Conjunctival Degeneration

Cellular components related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.4 CRYAA CYP1A1 CYP2B6 CYP2E1 DHX9 ITGB1
2 organelle membrane GO:0031090 9.13 CYP1A1 CYP2B6 CYP2E1

Biological processes related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to antibiotic GO:0046677 9.43 CYP1A1 TP53
2 steroid metabolic process GO:0008202 9.43 CYP1A1 CYP2B6 CYP2E1
3 exogenous drug catabolic process GO:0042738 9.4 CYP2B6 CYP2E1
4 organic acid metabolic process GO:0006082 9.37 CYP2B6 CYP2E1
5 positive regulation of protein export from nucleus GO:0046827 9.32 TP53 XPO4
6 heterocycle metabolic process GO:0046483 9.16 CYP1A1 CYP2E1
7 drug metabolic process GO:0017144 9.13 CYP1A1 CYP2B6 CYP2E1
8 epoxygenase P450 pathway GO:0019373 8.8 CYP1A1 CYP2B6 CYP2E1

Molecular functions related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.65 CYP1A1 CYP2B6 CYP2E1
2 heme binding GO:0020037 9.63 CYP1A1 CYP2B6 CYP2E1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.54 CYP1A1 CYP2B6 CYP2E1
4 damaged DNA binding GO:0003684 9.5 DCLRE1C TP53 XPA
5 histone acetyltransferase binding GO:0035035 9.49 PAX6 TP53
6 arachidonic acid epoxygenase activity GO:0008392 9.43 CYP2B6 CYP2E1
7 monooxygenase activity GO:0004497 9.43 CYP1A1 CYP2B6 CYP2E1
8 oxygen binding GO:0019825 9.33 CYP1A1 CYP2B6 CYP2E1
9 steroid hydroxylase activity GO:0008395 9.13 CYP1A1 CYP2B6 CYP2E1
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.8 CYP1A1 CYP2B6 CYP2E1
11 metal ion binding GO:0046872 10.06 CRYAA CYP1A1 CYP2B6 CYP2E1 DHX9 ITGB1

Sources for Conjunctival Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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