MCID: CNJ010
MIFTS: 20

Conjunctival Degeneration

Categories: Eye diseases

Aliases & Classifications for Conjunctival Degeneration

MalaCards integrated aliases for Conjunctival Degeneration:

Name: Conjunctival Degeneration 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10139
ICD9CM 34 372.50
SNOMED-CT 67 40787005
ICD10 32 H11.10
UMLS 71 C0155160

Summaries for Conjunctival Degeneration

MalaCards based summary : Conjunctival Degeneration is related to pinguecula and cri-du-chat syndrome. An important gene associated with Conjunctival Degeneration is XPO4 (Exportin 4), and among its related pathways/superpathways is Cell adhesion_Endothelial cell contacts by junctional mechanisms. Affiliated tissues include eye, kidney and skin, and related phenotype is normal.

Related Diseases for Conjunctival Degeneration

Diseases related to Conjunctival Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pinguecula 30.6 XPO4 PKP4 PAX6 JUP ARVCF ALDH3A1
2 cri-du-chat syndrome 10.0 PKP4 ARVCF
3 ectropion 9.9 PAX6 NIPAL4
4 eyelid disease 9.9 PAX6 NIPAL4
5 myeloma, multiple 9.8
6 keratitis, hereditary 9.6 RNGTT PAX6
7 keratopathy 9.5 TP53 PAX6

Graphical network of the top 20 diseases related to Conjunctival Degeneration:



Diseases related to Conjunctival Degeneration

Symptoms & Phenotypes for Conjunctival Degeneration

MGI Mouse Phenotypes related to Conjunctival Degeneration:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 ALDH3A1 JUP PAX6 PKP4 TP53 XPO4

Drugs & Therapeutics for Conjunctival Degeneration

Search Clinical Trials , NIH Clinical Center for Conjunctival Degeneration

Genetic Tests for Conjunctival Degeneration

Anatomical Context for Conjunctival Degeneration

MalaCards organs/tissues related to Conjunctival Degeneration:

40
Eye, Kidney, Skin

Publications for Conjunctival Degeneration

Articles related to Conjunctival Degeneration:

# Title Authors PMID Year
1
Dietary α-lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects. 61
23989186 2013
2
Analysis of the relationship between postoperative ophthalmic complications and dialysis time of pre-kidney transplantation. 61
22773990 2012
3
Ocular disorders in renal transplant patients. 61
18711290 2008
4
Metastatic or dystrophic conjunctival calcification in renal failure? 61
1450660 1992
5
Goniotrepanation (gotrep) and further observations on this operation for chronic glaucoma. 61
1078955 1975
6
[Case of multiple myeloma with skin manifestations and crystalline corneo-conjunctival degeneration]. 61
5758071 1968

Variations for Conjunctival Degeneration

Expression for Conjunctival Degeneration

Search GEO for disease gene expression data for Conjunctival Degeneration.

Pathways for Conjunctival Degeneration

Pathways related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 PKP4 JUP

GO Terms for Conjunctival Degeneration

Cellular components related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.33 PKP4 JUP ARVCF
2 cytoplasmic side of plasma membrane GO:0009898 9.32 PKP4 JUP
3 cornified envelope GO:0001533 9.26 PKP4 JUP
4 desmosome GO:0030057 8.96 PKP4 JUP
5 cell-cell adherens junction GO:0005913 8.8 PKP4 JUP ARVCF

Biological processes related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction assembly GO:0007043 9.26 PKP4 ARVCF
2 chromosome organization GO:0051276 9.16 TP53 DCLRE1C
3 cell-cell adhesion GO:0098609 9.13 PKP4 JUP ARVCF
4 positive regulation of protein export from nucleus GO:0046827 8.62 XPO4 TP53

Molecular functions related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.33 TP53 PAX6 CAMLG
2 histone acetyltransferase binding GO:0035035 8.96 TP53 PAX6
3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 8.62 ALDH3A1 ALDH16A1

Sources for Conjunctival Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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