MCID: CNJ006
MIFTS: 21

Conjunctival Intraepithelial Neoplasm

Categories: Cancer diseases, Eye diseases

Aliases & Classifications for Conjunctival Intraepithelial Neoplasm

MalaCards integrated aliases for Conjunctival Intraepithelial Neoplasm:

Name: Conjunctival Intraepithelial Neoplasm 12 15
Intraepithelial Neoplasia of Conjunctiva 12
Conjunctival Intraepithelial Neoplasia 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5465
NCIt 49 C6120
UMLS 71 C1333148

Summaries for Conjunctival Intraepithelial Neoplasm

Disease Ontology : 12 A pre-malignant neoplasm that is characterized by abnormal growth of dysplastic squamous epithelial cells on the surface of the eye that arises from the conjunctiva that is restricted within the epithelium.

MalaCards based summary : Conjunctival Intraepithelial Neoplasm, also known as intraepithelial neoplasia of conjunctiva, is related to squamous cell papilloma and papilloma. An important gene associated with Conjunctival Intraepithelial Neoplasm is S100A2 (S100 Calcium Binding Protein A2). The drugs Anti-Bacterial Agents and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Conjunctival Intraepithelial Neoplasm

Diseases related to Conjunctival Intraepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 10.0
2 papilloma 10.0
3 epidermoid cysts 9.9 S100A2 S100A1
4 chondromyxoid fibroma 9.8 S100A2 S100A1
5 epidermal appendage tumor 9.8 S100A2 S100A1
6 sarcomatoid renal cell carcinoma 9.3 S100A1 IFNA2

Graphical network of the top 20 diseases related to Conjunctival Intraepithelial Neoplasm:



Diseases related to Conjunctival Intraepithelial Neoplasm

Symptoms & Phenotypes for Conjunctival Intraepithelial Neoplasm

GenomeRNAi Phenotypes related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.4 S100A13
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 S100A10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.4 S100A13
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.4 S100A10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.4 S100A10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 S100A13
7 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.4 S100A10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.4 S100A13
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 S100A10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 S100A10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.4 S100A10 S100A13
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.35 IFNA2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.35 IFNA2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.35 IFNA2 S100A10
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.35 IFNA2

Drugs & Therapeutics for Conjunctival Intraepithelial Neoplasm

Drugs for Conjunctival Intraepithelial Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4
2 Alkylating Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Mitomycins Phase 4
6 Antiviral Agents Phase 4
7 Interferon-alpha Phase 4
8 Interferon alpha-2 Phase 4
9 interferons Phase 4
10 Immunologic Factors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial to Compare Topical Interferon Alfa 2b And Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia Completed NCT02199327 Phase 4 Mitomycin C;Interferon Alfa-2b

Search NIH Clinical Center for Conjunctival Intraepithelial Neoplasm

Genetic Tests for Conjunctival Intraepithelial Neoplasm

Anatomical Context for Conjunctival Intraepithelial Neoplasm

MalaCards organs/tissues related to Conjunctival Intraepithelial Neoplasm:

40
Eye

Publications for Conjunctival Intraepithelial Neoplasm

Articles related to Conjunctival Intraepithelial Neoplasm:

# Title Authors PMID Year
1
[Histopathology manifestation and imaging characteristics of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia]. 61
30220179 2018
2
p16INK4A expression is frequently increased in periorbital and ocular squamous lesions. 61
26400483 2015
3
Total regression of extensive conjunctival intraepithelial neoplasia with superficial corneal invasion treated with topical mitomycin C 0.02%. 61
22140408 2009
4
Conjunctival-corneal intraepithelial neoplasm in an Asian elephant (Elephas maximus). 61
17319149 2006
5
Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion. 61
16540490 2006
6
Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence. 61
15448502 2004
7
Unexpected histological findings in pterygium. 61
8115131 1993

Variations for Conjunctival Intraepithelial Neoplasm

Expression for Conjunctival Intraepithelial Neoplasm

Search GEO for disease gene expression data for Conjunctival Intraepithelial Neoplasm.

Pathways for Conjunctival Intraepithelial Neoplasm

GO Terms for Conjunctival Intraepithelial Neoplasm

Cellular components related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.92 S100A13 S100A10 S100A1 IFNA2

Molecular functions related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.13 S100A13 S100A10 S100A1
2 calcium ion binding GO:0005509 8.92 S100A2 S100A13 S100A10 S100A1

Sources for Conjunctival Intraepithelial Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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