MCID: CNJ006
MIFTS: 21

Conjunctival Intraepithelial Neoplasm

Categories: Cancer diseases, Eye diseases

Aliases & Classifications for Conjunctival Intraepithelial Neoplasm

MalaCards integrated aliases for Conjunctival Intraepithelial Neoplasm:

Name: Conjunctival Intraepithelial Neoplasm 12 15
Intraepithelial Neoplasia of Conjunctiva 12
Conjunctival Intraepithelial Neoplasia 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5465
NCIt 50 C6120
UMLS 72 C1333148

Summaries for Conjunctival Intraepithelial Neoplasm

Disease Ontology : 12 A pre-malignant neoplasm that is characterized by abnormal growth of dysplastic squamous epithelial cells on the surface of the eye that arises from the conjunctiva that is restricted within the epithelium.

MalaCards based summary : Conjunctival Intraepithelial Neoplasm, also known as intraepithelial neoplasia of conjunctiva, is related to squamous cell papilloma and papilloma. An important gene associated with Conjunctival Intraepithelial Neoplasm is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Pathways in cancer and Human T-cell leukemia virus 1 infection. The drugs Alkylating Agents and Interferon alpha-2 have been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Conjunctival Intraepithelial Neoplasm

Diseases related to Conjunctival Intraepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 10.0
2 papilloma 10.0
3 ameloblastic carcinoma 9.7 SLC2A1 CDKN2A
4 verrucous carcinoma 9.7 SLC2A1 CDKN2A
5 cellular schwannoma 9.6 SLC2A1 CDKN2A
6 penile disease 9.6 IFNA2 CDKN2A
7 penile cancer 9.5 IFNA2 CDKN2A
8 transitional cell carcinoma 9.5 IFNA2 CDKN2A
9 large intestine cancer 9.5 SLC2A1 CDKN2A
10 melanoma, cutaneous malignant 1 9.4 IFNA2 CDKN2A
11 t-cell leukemia 9.4 SLC2A1 CDKN2A
12 cervical cancer 9.2 SLC2A1 CDKN2A

Graphical network of the top 20 diseases related to Conjunctival Intraepithelial Neoplasm:



Diseases related to Conjunctival Intraepithelial Neoplasm

Symptoms & Phenotypes for Conjunctival Intraepithelial Neoplasm

Drugs & Therapeutics for Conjunctival Intraepithelial Neoplasm

Drugs for Conjunctival Intraepithelial Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Alkylating Agents Phase 4
2 Interferon alpha-2 Phase 4
3 Anti-Infective Agents Phase 4
4 Mitomycins Phase 4
5 Nucleic Acid Synthesis Inhibitors Phase 4
6 Interferon-alpha Phase 4
7 Anti-Bacterial Agents Phase 4
8 Antibiotics, Antitubercular Phase 4
9 interferons Phase 4
10 Immunologic Factors Phase 4
11 Antiviral Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial to Compare Topical Interferon Alfa 2b And Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia Completed NCT02199327 Phase 4 Mitomycin C;Interferon Alfa-2b

Search NIH Clinical Center for Conjunctival Intraepithelial Neoplasm

Genetic Tests for Conjunctival Intraepithelial Neoplasm

Anatomical Context for Conjunctival Intraepithelial Neoplasm

MalaCards organs/tissues related to Conjunctival Intraepithelial Neoplasm:

41
Eye

Publications for Conjunctival Intraepithelial Neoplasm

Articles related to Conjunctival Intraepithelial Neoplasm:

# Title Authors PMID Year
1
[Histopathology manifestation and imaging characteristics of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia]. 38
30220179 2018
2
p16INK4A expression is frequently increased in periorbital and ocular squamous lesions. 38
26400483 2015
3
Total regression of extensive conjunctival intraepithelial neoplasia with superficial corneal invasion treated with topical mitomycin C 0.02%. 38
22140408 2009
4
Conjunctival-corneal intraepithelial neoplasm in an Asian elephant (Elephas maximus). 38
17319149 2006
5
Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion. 38
16540490 2006
6
Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence. 38
15448502 2004
7
Unexpected histological findings in pterygium. 38
8115131 1993

Variations for Conjunctival Intraepithelial Neoplasm

Expression for Conjunctival Intraepithelial Neoplasm

Search GEO for disease gene expression data for Conjunctival Intraepithelial Neoplasm.

Pathways for Conjunctival Intraepithelial Neoplasm

Pathways related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.52 SLC2A1 IFNA2 CDKN2A
2 11.5 SLC2A1 CDKN2A
3 10.69 SLC2A1 CDKN2A

GO Terms for Conjunctival Intraepithelial Neoplasm

Sources for Conjunctival Intraepithelial Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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