MCID: CNJ006
MIFTS: 32

Conjunctival Intraepithelial Neoplasm

Categories: Cancer diseases, Eye diseases

Aliases & Classifications for Conjunctival Intraepithelial Neoplasm

MalaCards integrated aliases for Conjunctival Intraepithelial Neoplasm:

Name: Conjunctival Intraepithelial Neoplasm 12 15
Intraepithelial Neoplasia of Conjunctiva 12
Conjunctival Intraepithelial Neoplasia 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5465
NCIt 51 C6120
UMLS 74 C1333148

Summaries for Conjunctival Intraepithelial Neoplasm

Disease Ontology : 12 A pre-malignant neoplasm that is characterized by abnormal growth of dysplastic squamous epithelial cells on the surface of the eye that arises from the conjunctiva that is restricted within the epithelium.

MalaCards based summary : Conjunctival Intraepithelial Neoplasm, also known as intraepithelial neoplasia of conjunctiva, is related to squamous cell papilloma and papilloma. An important gene associated with Conjunctival Intraepithelial Neoplasm is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Human cytomegalovirus infection and Pathways in cancer. The drugs Anti-Bacterial Agents and Nucleic Acid Synthesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, cervix and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Conjunctival Intraepithelial Neoplasm

Diseases related to Conjunctival Intraepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.0 CDKN2A TP53
2 papilloma 30.0 CDKN2A TP53
3 conjunctival squamous cell carcinoma 10.1 IFNA2 TP53
4 sarcomatoid renal cell carcinoma 10.1 IFNA2 TP53
5 focal epithelial hyperplasia 10.1 IFNA2 TP53
6 acquired immunodeficiency syndrome 10.0 IFNA2 TP53
7 bladder squamous cell carcinoma 10.0 CDKN2A TP53
8 keratinizing squamous cell carcinoma 10.0 CDKN2A TP53
9 spitz nevus 10.0 CDKN2A TP53
10 bladder carcinoma in situ 10.0 CDKN2A TP53
11 vulva squamous cell carcinoma 10.0 CDKN2A TP53
12 scrotal carcinoma 10.0 CDKN2A TP53
13 thyroid lymphoma 10.0 CDKN2A TP53
14 vulvar disease 10.0 CDKN2A TP53
15 nasal cavity adenocarcinoma 10.0 CDKN2A TP53
16 bartholin's gland disease 10.0 CDKN2A TP53
17 anal squamous cell carcinoma 10.0 CDKN2A TP53
18 megaesophagus 10.0 CDKN2A TP53
19 glycogen-rich clear cell breast carcinoma 10.0 CDKN2A TP53
20 gastric adenosquamous carcinoma 10.0 CDKN2A TP53
21 anogenital venereal wart 10.0 CDKN2A TP53
22 cervix uteri carcinoma in situ 10.0 CDKN2A TP53
23 uterus carcinoma in situ 10.0 CDKN2A TP53
24 oral leukoplakia 10.0 CDKN2A TP53
25 meningeal melanomatosis 10.0 CDKN2A TP53
26 suppressor of tumorigenicity 3 10.0 CDKN2A TP53
27 dedifferentiated liposarcoma 10.0 CDKN2A TP53
28 liposarcoma 10.0 CDKN2A TP53
29 endocervical adenocarcinoma 10.0 CDKN2A TP53
30 cervical adenocarcinoma 10.0 CDKN2A TP53
31 cervix small cell carcinoma 10.0 CDKN2A TP53
32 small cell carcinoma 10.0 CDKN2A TP53
33 necrotizing sialometaplasia 10.0 CDKN2A TP53
34 verrucous carcinoma 10.0 CDKN2A TP53
35 basaloid squamous cell carcinoma 10.0 CDKN2A TP53
36 tongue disease 10.0 CDKN2A TP53
37 optic nerve neoplasm 10.0 CDKN2A TP53
38 juvenile pilocytic astrocytoma 10.0 CDKN2A TP53
39 tonsil cancer 10.0 CDKN2A TP53
40 pre-malignant neoplasm 10.0 CDKN2A TP53
41 vulva cancer 10.0 CDKN2A TP53
42 laryngeal disease 10.0 CDKN2A TP53
43 barrett's adenocarcinoma 9.9 CDKN2A TP53
44 oropharynx cancer 9.9 CDKN2A TP53
45 pharynx cancer 9.9 CDKN2A TP53
46 pancreatic ductal carcinoma 9.9 CDKN2A TP53
47 cervix carcinoma 9.9 CDKN2A TP53
48 skin squamous cell carcinoma 9.9 CDKN2A TP53
49 inverted papilloma 9.9 CDKN2A TP53
50 cellular schwannoma 9.9 CDKN2A TP53

Graphical network of the top 20 diseases related to Conjunctival Intraepithelial Neoplasm:



Diseases related to Conjunctival Intraepithelial Neoplasm

Symptoms & Phenotypes for Conjunctival Intraepithelial Neoplasm

GenomeRNAi Phenotypes related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.17 IFNA2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.17 IFNA2 TP53
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.17 IFNA2 TP53
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.17 IFNA2 TP53

Drugs & Therapeutics for Conjunctival Intraepithelial Neoplasm

Drugs for Conjunctival Intraepithelial Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4
2 Nucleic Acid Synthesis Inhibitors Phase 4
3 Interferon-alpha Phase 4
4 Alkylating Agents Phase 4
5 Interferon alpha-2 Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4
8 interferons Phase 4
9 Antiviral Agents Phase 4
10 Mitomycins Phase 4
11 Immunologic Factors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Interferon Alfa 2b and Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia Completed NCT02199327 Phase 4 Mitomycin C;Interferon Alfa-2b

Search NIH Clinical Center for Conjunctival Intraepithelial Neoplasm

Genetic Tests for Conjunctival Intraepithelial Neoplasm

Anatomical Context for Conjunctival Intraepithelial Neoplasm

MalaCards organs/tissues related to Conjunctival Intraepithelial Neoplasm:

42
Eye, Cervix, Tongue, Skin, Lung, Bone, Pancreas

Publications for Conjunctival Intraepithelial Neoplasm

Articles related to Conjunctival Intraepithelial Neoplasm:

# Title Authors Year
1
Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence. ( 15448502 )
2004

Variations for Conjunctival Intraepithelial Neoplasm

Expression for Conjunctival Intraepithelial Neoplasm

Search GEO for disease gene expression data for Conjunctival Intraepithelial Neoplasm.

Pathways for Conjunctival Intraepithelial Neoplasm

GO Terms for Conjunctival Intraepithelial Neoplasm

Biological processes related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.43 CDKN2A IFNA2 TP53
2 cell cycle arrest GO:0007050 9.4 CDKN2A TP53
3 negative regulation of cell growth GO:0030308 9.37 CDKN2A TP53
4 positive regulation of transcription, DNA-templated GO:0045893 9.33 CDKN2A IFNA2 TP53
5 Ras protein signal transduction GO:0007265 9.32 CDKN2A TP53
6 negative regulation of transcription, DNA-templated GO:0045892 9.13 CDKN2A IFNA2 TP53
7 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Conjunctival Intraepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Conjunctival Intraepithelial Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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