MCID: CNJ017
MIFTS: 28

Conjunctival Nevus

Categories: Cancer diseases, Eye diseases

Aliases & Classifications for Conjunctival Nevus

MalaCards integrated aliases for Conjunctival Nevus:

Name: Conjunctival Nevus 12 15 17
Nevus of Conjunctiva 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050906
UMLS 71 C0346363

Summaries for Conjunctival Nevus

Disease Ontology : 12 A sensory organ benign neoplasm that is located in the eye conjunctiva.

MalaCards based summary : Conjunctival Nevus, also known as nevus of conjunctiva, is related to malignant conjunctival melanoma and melanoma. An important gene associated with Conjunctival Nevus is MLANA (Melan-A), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Development Endothelin-1/EDNRA signaling. Affiliated tissues include eye, skin and endothelial, and related phenotype is pigmentation.

Related Diseases for Conjunctival Nevus

Diseases related to Conjunctival Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 malignant conjunctival melanoma 29.0 NRAS MLANA GNAQ GNA11 CCIN
2 melanoma 27.6 PRAME NRAS MLANA GNAQ GNA11 CSPG4
3 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
4 melanoma in congenital melanocytic nevus 10.0 NRAS MLANA
5 epithelioid cell melanoma 10.0 MLANA GNAQ
6 phakomatosis cesioflammea 10.0 GNAQ GNA11
7 melanotic neurilemmoma 10.0 MLANA GNAQ
8 ptosis 9.9
9 pseudopterygium 9.9
10 conjunctival pigmentation 9.9
11 malignant anus melanoma 9.9 NRAS MLANA GNAQ
12 meningeal melanocytoma 9.8 MLANA GNAQ GNA11
13 mongolian spot 9.8 MLANA GNAQ GNA11
14 mixed cell uveal melanoma 9.8 MLANA GNAQ GNA11
15 hypomelanosis of ito 9.7 GNAQ GNA11
16 sensory organ benign neoplasm 9.7 NRAS MLANA GNAQ CCIN
17 nevus, epidermal 9.7 NRAS GNAQ
18 mucosal melanoma 9.7 NRAS GNAQ GNA11
19 ocular melanoma 9.7 NRAS GNAQ GNA11
20 uveal disease 9.6 NRAS GNAQ GNA11
21 ocular cancer 9.6 MLANA GNAQ GNA11
22 malignant leptomeningeal tumor 9.6 NRAS MLANA GNAQ GNA11
23 meningeal melanoma 9.5 NRAS MLANA GNAQ GNA11
24 meningeal melanomatosis 9.5 NRAS MLANA GNAQ GNA11
25 melanomatosis 9.5 NRAS MLANA GNAQ GNA11
26 central nervous system melanocytic neoplasm 9.5 NRAS MLANA GNAQ GNA11
27 malignant dermis tumor 9.5 NRAS MLANA GNAQ GNA11
28 malignant skin fibrous histiocytoma 9.5 NRAS MLANA GNAQ GNA11
29 vulvar melanoma 9.5 NRAS MLANA GNAQ GNA11
30 malignant spindle cell melanoma 9.5 NRAS MLANA GNAQ GNA11
31 nodular malignant melanoma 9.5 NRAS MLANA GNAQ GNA11
32 skin melanoma 9.5 NRAS MLANA GNAQ GNA11
33 acral lentiginous melanoma 9.5 NRAS GNAQ CSPG4
34 melanoma, cutaneous malignant 1 9.4 NRAS MLANA GNAQ GNA11
35 conjunctival cancer 9.3 NRAS MLANA GNAQ GNA11 CCIN
36 melanoma, uveal 9.0 PRAME NRAS MLANA GNAQ GNA11

Graphical network of the top 20 diseases related to Conjunctival Nevus:



Diseases related to Conjunctival Nevus

Symptoms & Phenotypes for Conjunctival Nevus

MGI Mouse Phenotypes related to Conjunctival Nevus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 GNA11 GNAQ MLANA NRAS

Drugs & Therapeutics for Conjunctival Nevus

Search Clinical Trials , NIH Clinical Center for Conjunctival Nevus

Genetic Tests for Conjunctival Nevus

Anatomical Context for Conjunctival Nevus

MalaCards organs/tissues related to Conjunctival Nevus:

40
Eye, Skin, Endothelial, Heart, Tongue

Publications for Conjunctival Nevus

Articles related to Conjunctival Nevus:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Search for histopathological characteristics of inflammatory juvenile conjunctival nevus in conjunctival nevi related to age: Analysis of 33 cases. 61
31686961 2019
2
Urea-De-Epithelialized Human Amniotic Membrane for Ocular Surface Reconstruction. 61
30868769 2019
3
The Amazon Ocular Oncology Center: The first three years. 61
30698230 2019
4
Conjunctival Melanoma in Asian Indians: A Study of 42 Patients. 61
31135259 2019
5
Regressing Conjunctival Nevus in a Child. 61
30479722 2018
6
Surgical management of a conjunctival nevus with amniotic membrane transplantation. 61
30100765 2018
7
Conjunctival melanocytic tumors in children - a challenge in diagnosis and treatment. 61
29940644 2018
8
[Analysis of clinicopathologic characteristics of 422 conjunctival melanocytic nevi specimens]. 61
28851198 2017
9
Cellular Blue Nevus of Perilimbal Conjunctiva: A Case Report and Review of Literature. 61
28801376 2017
10
Surgical amniotic membrane transplantation after conjunctival and limbal tumor excision. 61
28954025 2017
11
Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review. 61
29250649 2017
12
Giant Conjunctival Nevus in a 12-Year-Old Child. 61
28912992 2017
13
[The role of reflectance confocal microscopy and optical coherence tomography in the diagnosis of epithelial-cystic conjunctival nevus]. 61
27364899 2016
14
Efficacy of Pattern Scan Laser photocoagulation for superficial conjunctival nevi ablation. 61
26914686 2016
15
Interleukin-17 and its correlation with vascular endothelial growth factor expression in ocular surface pathologies: a histologic study. 61
26615952 2016
16
Inverted mucoepidermoid papilloma of conjunctiva in a child. 61
25818286 2015
17
Usefulness of a red chromagen in the diagnosis of melanocytic lesions of the conjunctiva. 61
24626521 2014
18
Giant conjunctival nevus: clinical features and natural course in 32 cases. 61
23702735 2013
19
Argon laser photoablation of superficial conjunctival nevus: results of a 3-year study. 61
23394912 2013
20
Therapy of melanocytic conjunctival tumors. 61
23944618 2013
21
[The pathological analysis of 213 children with ocular tumor]. 61
23601464 2013
22
A circum-corneal conjunctival nevus in a child. 61
22551371 2012
23
[Clinical findings and prognosis of 11 cases of conjunctival malignant melanoma]. 61
22690541 2012
24
MUC5AC in juvenile conjunctival nevus. 61
22139382 2012
25
Ophthaproblem. Can you identify this condition? Conjunctival nevus. 61
21998233 2011
26
Ocular morbidity among primary school children of Dhulikhel, Nepal. 61
21876593 2011
27
Anterior segment optical coherence tomography of conjunctival nevus. 61
21146221 2011
28
Conjunctival nevus-like lesions originating from a sclerotomy site after 23-gauge transconjunctival sutureless vitrectomy. 61
20577862 2010
29
Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in conjunctival melanomas and clinical implications. 61
20577856 2010
30
[Suspicious conjunctival lesions]. 61
20096479 2010
31
Conjunctival nevi clinical features and therapeutic outcomes. 61
19896191 2010
32
Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases. 61
18300811 2008
33
[Conjunctival nevus--clinical case]. 61
18714494 2008
34
Conjunctival tumors in children. 61
17700226 2007
35
[Inflammatory juvenile conjunctival nevus (IJCN)]. 61
17516373 2007
36
Conjunctival nevus and melanoma. 61
17972544 2007
37
What is your diagnosis? Conjunctival nevus. 61
17162967 2006
38
Treatment of large conjunctival nevus by resection and reconstruction using amniotic membrane. 61
16315045 2006
39
[Epidemiology of ocular and orbital lesions referred to an ocular oncology center]. 61
16249763 2005
40
Reconstruction of the ocular surface by transplantation of a serum-free derived cultivated conjunctival epithelial equivalent. 61
15201674 2004
41
Conjunctival nevi: clinical features and natural course in 410 consecutive patients. 61
14769591 2004
42
Ultrasound biomicroscopy in pigmented conjunctival cystic nevi. 61
14701967 2004
43
Amniotic membrane transplantation for conjunctival tumor. 61
14574973 2003
44
[Progressive peripunctal nevus in an adult]. 61
12820016 2003
45
Preoperative brush and impression cytology in ocular surface squamous neoplasms. 61
12585025 2003
46
Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus. 61
12036989 2002
47
[Association of nevus and herpetic keratitis sequela. Apropos of an anatomo-clinical case]. 61
10221204 1999
48
Conjunctival melanoma associated with extensive congenital conjunctival nevus and split nevus of eyelid. 61
10037580 1999
49
[Epithelial-cystic nevus of the conjunctiva (Parinaud's dermo-epithelioma)]. 61
8714115 1996
50
[A hardened patch on the thigh. Conjunctival nevus of the collagen type (NCC) which is also called conjunctival nevus of the fibromatous type, collagenoma, collagen hamartoma or fibromatous hamartoma]. 61
7702673 1995

Variations for Conjunctival Nevus

Expression for Conjunctival Nevus

Search GEO for disease gene expression data for Conjunctival Nevus.

Pathways for Conjunctival Nevus

Pathways related to Conjunctival Nevus according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 NRAS GNAQ GNA11
2
Show member pathways
12.29 NRAS GNAQ GNA11
3 12.25 GNAQ GNA11 CSPG4
4
Show member pathways
12.11 NRAS GNAQ GNA11
5
Show member pathways
11.59 NRAS GNAQ GNA11
6 11.38 NRAS GNAQ GNA11
7 11.36 GNAQ GNA11
8 11.28 NRAS GNAQ GNA11
9 11.2 GNAQ GNA11
10 11.05 GNAQ GNA11
11 10.98 GNAQ GNA11
12 10.94 GNAQ GNA11
13 10.94 NRAS GNAQ GNA11
14 10.67 NRAS GNAQ
15 10.58 NRAS GNAQ GNA11
16
Show member pathways
10.46 GNAQ GNA11

GO Terms for Conjunctival Nevus

Cellular components related to Conjunctival Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 8.96 GNAQ GNA11
2 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Conjunctival Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.37 GNAQ GNA11
2 action potential GO:0001508 9.32 GNAQ GNA11
3 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.26 GNAQ GNA11
4 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.16 GNAQ GNA11
5 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
6 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Conjunctival Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.54 NRAS GNAQ GNA11
2 GTPase activity GO:0003924 9.43 NRAS GNAQ GNA11
3 G protein-coupled receptor binding GO:0001664 9.32 GNAQ GNA11
4 G-protein beta/gamma-subunit complex binding GO:0031683 9.16 GNAQ GNA11
5 guanyl nucleotide binding GO:0019001 8.96 GNAQ GNA11
6 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Conjunctival Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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