MCID: CNJ017
MIFTS: 26

Conjunctival Nevus

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Conjunctival Nevus

MalaCards integrated aliases for Conjunctival Nevus:

Name: Conjunctival Nevus 12 15 17
Nevus of Conjunctiva 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050906
UMLS 71 C0346363

Summaries for Conjunctival Nevus

Disease Ontology : 12 A sensory organ benign neoplasm that is located in the eye conjunctiva.

MalaCards based summary : Conjunctival Nevus, also known as nevus of conjunctiva, is related to conjunctival pigmentation and malignant conjunctival melanoma. An important gene associated with Conjunctival Nevus is MLANA (Melan-A), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Oxytocin signaling pathway. Affiliated tissues include eye and endothelial, and related phenotype is pigmentation.

Related Diseases for Conjunctival Nevus

Diseases related to Conjunctival Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 conjunctival pigmentation 30.0 SOX10 MLANA
2 malignant conjunctival melanoma 29.5 NRAS MLANA HRAS GNAQ
3 melanoma 28.7 SOX10 PRAME NRAS MLANA HRAS GNAQ
4 ovarian melanoma 10.2 NRAS MLANA
5 sensory organ benign neoplasm 10.2 NRAS MLANA
6 meningeal melanocytoma 10.1 MLANA GNAQ
7 mongolian spot 10.1 MLANA GNAQ
8 gallbladder melanoma 10.1 SOX10 MLANA
9 hypomelanosis of ito 10.1 NRAS GNAQ
10 sarcomatoid squamous cell skin carcinoma 10.1 SOX10 MLANA
11 malignant choroid melanoma 10.1 SOX10 MLANA
12 epithelioid malignant peripheral nerve sheath tumor 10.1 SOX10 MLANA
13 acneiform dermatitis 10.0 NRAS HRAS
14 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
15 mucosal melanoma 10.0 NRAS GNAQ
16 core binding factor acute myeloid leukemia 10.0 NRAS HRAS
17 oculoectodermal syndrome 10.0 NRAS HRAS
18 nasal cavity cancer 10.0 MLANA HRAS
19 large intestine adenocarcinoma 10.0 NRAS HRAS
20 melanocytic nevus syndrome, congenital 10.0 NRAS HRAS
21 benign struma ovarii 10.0 NRAS HRAS
22 vulvar disease 10.0 NRAS HRAS
23 meningeal melanoma 10.0 NRAS MLANA GNAQ
24 melanomatosis 10.0 NRAS MLANA GNAQ
25 ocular melanoma 10.0 NRAS GNAQ
26 acral lentiginous melanoma 10.0 NRAS HRAS
27 respiratory system benign neoplasm 10.0 MLANA HRAS
28 myelodysplastic/myeloproliferative neoplasm 10.0 NRAS HRAS
29 malignant leptomeningeal tumor 10.0 NRAS MLANA GNAQ
30 orbit rhabdomyosarcoma 10.0 NRAS MLANA GNAQ
31 ras-associated autoimmune leukoproliferative disorder 9.9 NRAS HRAS
32 choroid cancer 9.9 PRAME MLANA
33 clear cell sarcoma 9.9 SOX10 MLANA
34 schimmelpenning-feuerstein-mims syndrome 9.9 NRAS HRAS
35 thyroid cancer, nonmedullary, 2 9.9 NRAS HRAS
36 ptosis 9.9
37 pseudopterygium 9.9
38 malignant anus melanoma 9.9 NRAS MLANA HRAS
39 nevus, epidermal 9.8 NRAS HRAS GNAQ
40 uveal disease 9.8 NRAS HRAS GNAQ
41 nasal cavity adenocarcinoma 9.8 SOX10 MLANA HRAS
42 skin benign neoplasm 9.8 MLANA HRAS
43 pilocytic astrocytoma 9.7 SOX10 NRAS HRAS
44 actinic keratosis 9.7 SOX10 HRAS
45 neurofibromatosis, type i 9.7 SOX10 NRAS HRAS
46 meningeal melanomatosis 9.6 NRAS MLANA HRAS GNAQ
47 malignant dermis tumor 9.6 NRAS MLANA HRAS GNAQ
48 central nervous system melanocytic neoplasm 9.6 NRAS MLANA HRAS GNAQ
49 malignant skin fibrous histiocytoma 9.6 NRAS MLANA HRAS GNAQ
50 vulvar melanoma 9.6 NRAS MLANA HRAS GNAQ

Graphical network of the top 20 diseases related to Conjunctival Nevus:



Diseases related to Conjunctival Nevus

Symptoms & Phenotypes for Conjunctival Nevus

MGI Mouse Phenotypes related to Conjunctival Nevus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 GNAQ MLANA NRAS SOX10

Drugs & Therapeutics for Conjunctival Nevus

Search Clinical Trials , NIH Clinical Center for Conjunctival Nevus

Genetic Tests for Conjunctival Nevus

Anatomical Context for Conjunctival Nevus

MalaCards organs/tissues related to Conjunctival Nevus:

40
Eye, Endothelial

Publications for Conjunctival Nevus

Articles related to Conjunctival Nevus:

(show top 50) (show all 60)
# Title Authors PMID Year
1
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders. 61
33591034 2021
2
Management of Inflamed Conjunctival Nevus with Topical Antiallergic Medications: Case Series. 61
33603334 2021
3
Conjunctival Melanoma: Outcomes based on the American Joint Committee on Cancer Clinical Classification (8th Edition) of 425 Patients at a Single Ocular Oncology Center. 61
33306519 2020
4
Genomic analysis of adult case of ocular surface giant congenital melanocytic nevus and associated clinicopathological findings. 61
32814477 2020
5
Ocular and Periocular Tumors in Asian Indian Children and Adolescents. 61
32221055 2020
6
Differential diagnosis and management of melanocytic lesions of the ocular surface 61
32320191 2020
7
Search for histopathological characteristics of inflammatory juvenile conjunctival nevus in conjunctival nevi related to age: Analysis of 33 cases. 61
31686961 2019
8
Urea-De-Epithelialized Human Amniotic Membrane for Ocular Surface Reconstruction. 61
30868769 2019
9
The Amazon Ocular Oncology Center: The first three years. 61
30698230 2019
10
Conjunctival Melanoma in Asian Indians: A Study of 42 Patients. 61
31135259 2019
11
Regressing Conjunctival Nevus in a Child. 61
30479722 2018
12
Conjunctival melanocytic tumors in children - a challenge in diagnosis and treatment. 61
29940644 2018
13
Surgical management of a conjunctival nevus with amniotic membrane transplantation. 61
30100765 2018
14
[Analysis of clinicopathologic characteristics of 422 conjunctival melanocytic nevi specimens]. 61
28851198 2017
15
Cellular Blue Nevus of Perilimbal Conjunctiva: A Case Report and Review of Literature. 61
28801376 2017
16
Surgical amniotic membrane transplantation after conjunctival and limbal tumor excision. 61
28954025 2017
17
Giant Conjunctival Nevus in a 12-Year-Old Child. 61
28912992 2017
18
Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review. 61
29250649 2017
19
[The role of reflectance confocal microscopy and optical coherence tomography in the diagnosis of epithelial-cystic conjunctival nevus]. 61
27364899 2016
20
Efficacy of Pattern Scan Laser photocoagulation for superficial conjunctival nevi ablation. 61
26914686 2016
21
Interleukin-17 and its correlation with vascular endothelial growth factor expression in ocular surface pathologies: a histologic study. 61
26615952 2016
22
Inverted mucoepidermoid papilloma of conjunctiva in a child. 61
25818286 2015
23
Usefulness of a red chromagen in the diagnosis of melanocytic lesions of the conjunctiva. 61
24626521 2014
24
Giant conjunctival nevus: clinical features and natural course in 32 cases. 61
23702735 2013
25
Argon laser photoablation of superficial conjunctival nevus: results of a 3-year study. 61
23394912 2013
26
Therapy of melanocytic conjunctival tumors. 61
23944618 2013
27
[The pathological analysis of 213 children with ocular tumor]. 61
23601464 2013
28
A circum-corneal conjunctival nevus in a child. 61
22551371 2012
29
[Clinical findings and prognosis of 11 cases of conjunctival malignant melanoma]. 61
22690541 2012
30
MUC5AC in juvenile conjunctival nevus. 61
22139382 2012
31
Ophthaproblem. Can you identify this condition? Conjunctival nevus. 61
21998233 2011
32
Ocular morbidity among primary school children of Dhulikhel, Nepal. 61
21876593 2011
33
Anterior segment optical coherence tomography of conjunctival nevus. 61
21146221 2011
34
Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in conjunctival melanomas and clinical implications. 61
20577856 2010
35
Conjunctival nevus-like lesions originating from a sclerotomy site after 23-gauge transconjunctival sutureless vitrectomy. 61
20577862 2010
36
[Suspicious conjunctival lesions]. 61
20096479 2010
37
Conjunctival nevi clinical features and therapeutic outcomes. 61
19896191 2010
38
Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases. 61
18300811 2008
39
[Conjunctival nevus--clinical case]. 61
18714494 2008
40
Conjunctival tumors in children. 61
17700226 2007
41
[Inflammatory juvenile conjunctival nevus (IJCN)]. 61
17516373 2007
42
Conjunctival nevus and melanoma. 61
17972544 2007
43
What is your diagnosis? Conjunctival nevus. 61
17162967 2006
44
Treatment of large conjunctival nevus by resection and reconstruction using amniotic membrane. 61
16315045 2006
45
[Epidemiology of ocular and orbital lesions referred to an ocular oncology center]. 61
16249763 2005
46
Reconstruction of the ocular surface by transplantation of a serum-free derived cultivated conjunctival epithelial equivalent. 61
15201674 2004
47
Conjunctival nevi: clinical features and natural course in 410 consecutive patients. 61
14769591 2004
48
Ultrasound biomicroscopy in pigmented conjunctival cystic nevi. 61
14701967 2004
49
Amniotic membrane transplantation for conjunctival tumor. 61
14574973 2003
50
[Progressive peripunctal nevus in an adult]. 61
12820016 2003

Variations for Conjunctival Nevus

Expression for Conjunctival Nevus

Search GEO for disease gene expression data for Conjunctival Nevus.

Pathways for Conjunctival Nevus

Pathways related to Conjunctival Nevus according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 NRAS HRAS GNAQ
2
Show member pathways
12.23 NRAS HRAS GNAQ
3 11.79 NRAS HRAS GNAQ
4
Show member pathways
11.78 NRAS HRAS GNAQ
5 11.68 NRAS HRAS GNAQ
6 11.64 NRAS HRAS GNAQ
7 11.6 NRAS HRAS GNAQ
8
Show member pathways
11.54 NRAS HRAS GNAQ
9 11.47 NRAS HRAS GNAQ
10 11.38 NRAS HRAS
11 11.38 NRAS HRAS GNAQ
12 11.29 NRAS HRAS
13 11.23 NRAS HRAS
14 11.16 NRAS HRAS
15 11.14 NRAS HRAS GNAQ
16 11.09 NRAS HRAS
17 11.04 NRAS HRAS
18 11.03 NRAS HRAS
19
Show member pathways
11.01 NRAS HRAS
20
Show member pathways
10.95 NRAS HRAS
21 10.91 NRAS HRAS GNAQ
22 10.89 NRAS HRAS
23 10.85 NRAS HRAS
24 10.57 NRAS HRAS
25 10.1 NRAS HRAS GNAQ

GO Terms for Conjunctival Nevus

Molecular functions related to Conjunctival Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activity GO:0003924 8.8 NRAS HRAS GNAQ

Sources for Conjunctival Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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