MCID: CNJ018
MIFTS: 40

Conjunctival Squamous Cell Carcinoma

Categories: Cancer diseases, Neuronal diseases, Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Conjunctival Squamous Cell Carcinoma

MalaCards integrated aliases for Conjunctival Squamous Cell Carcinoma:

Name: Conjunctival Squamous Cell Carcinoma 11 14 16 75
Squamous Cell Carcinoma of Conjunctiva 11 71 33
Invasive Squamous Cell Carcinoma of the Conjunctiva 11
Conjunctival Epidermoid Carcinoma 11
Ocular Surface Squamous Neoplasia 11

Classifications:



External Ids:

Disease Ontology 11 DOID:1748
NCIt 49 C4549
SNOMED-CT 68 255003007
ICD11 33 1856595996
UMLS 71 C0346359

Summaries for Conjunctival Squamous Cell Carcinoma

Disease Ontology: 11 A conjunctival cancer characterized by abnormal growth of dysplastic squamous epithelial cells on the surface of the eye that arises from the conjunctiva that has infiltrated beyond the confines of the epithelial basement membrane.

MalaCards based summary: Conjunctival Squamous Cell Carcinoma, also known as squamous cell carcinoma of conjunctiva, is related to keratitis, hereditary and conjunctival cancer. An important gene associated with Conjunctival Squamous Cell Carcinoma is ADAM3A (ADAM Metallopeptidase Domain 3A (Pseudogene)), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Inhibition of Ribosome Biogenesis by p14(ARF). The drugs Mitomycin and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and t cells.

Wikipedia: 75 Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise... more...

Related Diseases for Conjunctival Squamous Cell Carcinoma

Diseases related to Conjunctival Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 30.7 KRT3 KRT12 CD4
2 conjunctival cancer 30.6 TP53 KRT12 IFNA2 CDKN2A
3 corneal intraepithelial neoplasm 30.5 IFNA2 IFNA1
4 pseudopterygium 30.5 KRT3 KRT12
5 papilloma 30.5 TYMS TP53 CDKN2A
6 acquired immunodeficiency syndrome 30.4 TP53 IFNA2 IFNA1 CD4
7 basosquamous carcinoma 30.4 TP53 KRT15
8 cervix uteri carcinoma in situ 30.4 TP53 CDKN2A CD4
9 basaloid squamous cell carcinoma 30.4 TP53 CDKN2A
10 actinic keratosis 30.4 TP53 IFNA1 CDKN2A CD4
11 punctate epithelial keratoconjunctivitis 30.3 KRT3 IFNA2
12 recurrent corneal erosion 30.2 KRT3 KRT12
13 conjunctival disease 30.2 IFNA2 IFNA1 CD4
14 conjunctival intraepithelial neoplasm 30.1 S100A2 IFNA2
15 keratopathy 30.1 KRT3 KRT12
16 human papillomavirus infectious disease 30.1 TP53 CDKN2A CD4
17 epidermodysplasia verruciformis 1 30.0 TP53 CDKN2A CD4
18 basal cell carcinoma 29.9 TP53 S100A2 KRT15 CDKN2A
19 eye disease 29.2 TP53 KRT3 KRT12 IFNA1 CDKN2A CD4
20 squamous cell carcinoma 10.9
21 immune deficiency disease 10.5
22 mucolipidosis iv 10.4
23 keratosis 10.4
24 hypopyon 10.4
25 xeroderma pigmentosum, variant type 10.3
26 viral infectious disease 10.3
27 lymphomatoid granulomatosis 10.3 IFNA2 IFNA1
28 ige responsiveness, atopic 10.3
29 dermatitis, atopic 10.3
30 basal cell carcinoma 1 10.3
31 keratomalacia 10.3
32 dermatitis 10.3
33 49, xxxxy syndrome 10.3
34 atopic keratoconjunctivitis 10.3
35 cryoglobulinemia, familial mixed 10.3 IFNA2 IFNA1
36 human immunodeficiency virus type 1 10.3
37 focal epithelial hyperplasia 10.3 TP53 IFNA2
38 necrotizing sialometaplasia 10.2 TP53 KRT15
39 geniculate ganglionitis 10.2 IFNA2 CD4
40 eccrine sweat gland cancer 10.2 TP53 KRT15
41 sebaceous gland neoplasm 10.2 TP53 KRT15
42 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.2 TP53 CDKN2A
43 endometrial squamous cell carcinoma 10.2 TP53 CDKN2A
44 esophagus verrucous carcinoma 10.2 TP53 CDKN2A
45 verrucous carcinoma 10.2 TP53 CDKN2A
46 gastric antral vascular ectasia 10.2
47 mucoepidermoid carcinoma 10.2
48 papillon-lefevre syndrome 10.2
49 pinguecula 10.2
50 excessive tearing 10.2

Graphical network of the top 20 diseases related to Conjunctival Squamous Cell Carcinoma:



Diseases related to Conjunctival Squamous Cell Carcinoma

Symptoms & Phenotypes for Conjunctival Squamous Cell Carcinoma

Drugs & Therapeutics for Conjunctival Squamous Cell Carcinoma

Drugs for Conjunctival Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitomycin Approved 50-07-7 5746
2 Fibrin Tissue Adhesive
3 Anti-Bacterial Agents
4 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Treatment of Diffuse Conjunctival Squamous Cell Carcinoma (CSCC) With Excision, Amniotic Membrane Graft Using Fibrin Glue and Topical Mitomycin C (MMC) Completed NCT03515954
2 Feasibility Study of Ocular Surface Squamous Neoplasia (OSSN) Surgical Excision in People Living With HIV in Sub-Saharan Africa (SSA) Not yet recruiting NCT04704648

Search NIH Clinical Center for Conjunctival Squamous Cell Carcinoma

Genetic Tests for Conjunctival Squamous Cell Carcinoma

Anatomical Context for Conjunctival Squamous Cell Carcinoma

Organs/tissues related to Conjunctival Squamous Cell Carcinoma:

MalaCards : Eye, Skin, T Cells, Retina, Endothelial, Liver

Publications for Conjunctival Squamous Cell Carcinoma

Articles related to Conjunctival Squamous Cell Carcinoma:

(show top 50) (show all 619)
# Title Authors PMID Year
1
Clinicopathological characteristics of ocular surface squamous neoplasia: a 10-year review form a referral tertiary centre in Nigeria. 62
35802299 2022
2
Brachytherapy as a curative option for ocular surface squamous neoplasia. 62
36436169 2022
3
Anterior segment optical coherence tomography characteristics of conjunctival papilloma as compared to papilliform ocular surface squamous neoplasia. 62
36402855 2022
4
Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia. 62
36367558 2022
5
Pegylated Interferon Alpha 2a for the Treatment of Ocular Surface Squamous Neoplasia. 62
36107845 2022
6
Metastatic conjunctival squamous cell carcinoma: a study of 5 patients. 62
35524835 2022
7
HPV16 conjunctival squamous cell carcinoma. 62
36377068 2022
8
Ocular Surface Squamous Neoplasia Masquerading as Recalcitrant Epithelial Keratitis. 62
34907943 2022
9
Unresectable and chemoresistant conjunctival squamous cell carcinoma on xeroderma pigmentosum treated by salvage radiation therapy: A case report and a review of the literature. 62
36188050 2022
10
Supportive treatment to chemotherapy with MMC, in patients with ocular surface squamous neoplasia or conjunctival melanocytic tumor. 62
36074189 2022
11
Molluscum Contagiosum Masquerading as Ocular Surface Squamous Neoplasia. 62
35760591 2022
12
OVOL1 immunohistochemical expression is a useful tool to diagnose invasion in ocular surface squamous neoplasms. 62
35787378 2022
13
Spontaneous regression of presumed ocular surface squamous neoplasia: A report of 8 cases. 62
34747253 2022
14
Ocular surface squamous neoplasia with 360° limbal involvement: a study of 130 patients. 62
35951148 2022
15
Topical Chemotherapy for Treating Ocular Surface Squamous Neoplasia with a Combination of Interferon α-2b and 5-Fluorouracil. 62
35704159 2022
16
Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis. 62
35987957 2022
17
Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region. 62
34262162 2022
18
Ocular Surface Squamous Neoplasia: A 12-Month Prospective Evaluation of Incidence in Waikato, New Zealand. 62
35997381 2022
19
Midterm results of conjunctival reconstruction with buccal mucosa and amniotic membrane after resecting ocular surface squamous neoplasia of the fornix. 62
35940212 2022
20
Holding back the tears: is there a role for marsupialisation? 62
36161857 2022
21
Conjunctival myxoma masquerading as conjunctival lymphoma: A case report. 62
35872550 2022
22
The Use of Panitumumab-IRDye800CW in a Novel Murine Model for Conjunctival Squamous Cell Carcinoma. 62
35895055 2022
23
Clinicopathological profile, management and clinical outcomes in recurrent cases of ocular surface squamous neoplasia at a tertiary care centre. 62
35857192 2022
24
Occurrence of Occult Neoplasia in Pterygium Specimens Among Hispanic and Non-Hispanic Patients. 62
35180019 2022
25
Bulbar conjunctival rhinosporidiosis mimicking ocular surface squamous neoplasia. 62
35900515 2022
26
The clinical presentation and treatment of an invasive conjunctival squamous spindle cell carcinoma. 62
36248073 2022
27
Optical coherence tomography angiography in the evaluation of vascular patterns of ocular surface squamous neoplasia during topical medical treatment. 62
35358712 2022
28
Racial and socioeconomic disparities in ocular surface squamous neoplasia: a National Cancer Database analysis. 62
33977826 2022
29
Ocular surface squamous neoplasia in India: a study of 438 patients. 62
35094225 2022
30
Management of coexisting bilateral ocular surface disease in xeroderma pigmentosum - sequence and outcomes. 62
35535407 2022
31
Identification of Metastatic Conjunctival Squamous Cell Carcinoma through Neck Palpation. 62
35950032 2022
32
Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico. 62
35438930 2022
33
Clinical and Optical Coherence Tomography Comparison Between Ocular Surface Squamous Neoplasia and Squamous Metaplasia. 62
35439777 2022
34
Treatment challenges associated with a superiorly located bulbar conjunctival mass-case report and review of the literature. 62
35128156 2022
35
Conjunctival Lesions: A 5-Year Basic Demographic Data and Clinicopathological Review in a Tertiary Eye Care Hospital. 62
34846715 2022
36
Amniotic Membrane Grafting for Ocular Surface Inflammation Following Topical Interferon Alpha 2b Therapy. 62
35298286 2022
37
Ocular surface squamous neoplasia in Northern Thailand: a 16-year review. 62
35279126 2022
38
Clinical Significance of Cyclin Expression Profiling in Ocular Surface Squamous Neoplasia. 62
34657082 2022
39
A case of sight threatening complications from topical 1% 5-fluorouracil in the treatment of ocular surface squamous neoplasia. 62
35128150 2022
40
Masquerade syndrome in ocular surface squamous neoplasia. 62
35417519 2022
41
Immunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma. 62
35225554 2022
42
Pterygium and Ocular Surface Squamous Neoplasia: Optical Biopsy Using a Novel Autofluorescence Multispectral Imaging Technique. 62
35326744 2022
43
The impact of the COVID-19 pandemic on the diagnosis and treatment of ocular cancer. 62
35417515 2022
44
Ocular Surface Squamous Neoplasia With Coexistent Microbial Keratitis: Incidence, Risk Factors, Clinical Features, Microbiological Profile, and Treatment Outcome. 62
34294636 2022
45
Histopathological Rate of Ocular Surface Squamous Neoplasia in Clinically Suspected Pterygium Specimens: 10-Year Results. 62
34690264 2022
46
Ocular surface squamous neoplasia with orbital tumour extension: risk factors and outcomes. 62
35115716 2022
47
Visualizing Ocular Surface Squamous Neoplasia. 62
35065728 2022
48
Spontaneous rupture of ocular surface squamous neoplasia-a case report. 62
35186700 2022
49
Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia. 62
35388258 2022
50
Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia. 62
34838574 2022

Variations for Conjunctival Squamous Cell Carcinoma

Cosmic variations for Conjunctival Squamous Cell Carcinoma:

8 (show top 50) (show all 318)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM144706553 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.589T>C p.Y197H 17:7674257-7674257 14
2 COSM144020377 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.692G>T p.C231F 17:7674238-7674238 14
3 COSM122323579 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.310T>C p.Y104H 17:7674257-7674257 14
4 COSM142560375 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.736G>A p.E246K 17:7673767-7673767 14
5 COSM121886355 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.8G>T p.C3F 17:7675208-7675208 14
6 COSM111766278 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.725G>T p.C242F 17:7674238-7674238 14
7 COSM142568532 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.287G>T p.C96F 17:7675208-7675208 14
8 COSM93191077 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.725G>T p.C242F 17:7674238-7674238 14
9 COSM106105114 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 14
10 COSM121876085 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.457G>A p.E153K 17:7673767-7673767 14
11 COSM93239210 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 14
12 COSM144087163 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.376G>A p.E126K 17:7673767-7673767 14
13 COSM106053265 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 14
14 COSM122741996 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.8G>T p.C3F 17:7675208-7675208 14
15 COSM143949949 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.248G>T p.C83F 17:7674238-7674238 14
16 COSM122271649 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.457G>A p.E153K 17:7673767-7673767 14
17 COSM122278514 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.329G>T p.C110F 17:7674238-7674238 14
18 COSM112260228 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.725G>T p.C242F 17:7674238-7674238 14
19 COSM112253698 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 14
20 COSM145025120 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.608G>T p.C203F 17:7674238-7674238 14
21 COSM145067318 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.589T>C p.Y197H 17:7674257-7674257 14
22 COSM112261547 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 14
23 COSM87908091 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 14
24 COSM143951100 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.-74G>T p.? 17:7675208-7675208 14
25 COSM145017758 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.736G>A p.E246K 17:7673767-7673767 14
26 COSM144092148 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.248G>T p.C83F 17:7674238-7674238 14
27 COSM144659280 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.608G>T p.C203F 17:7674238-7674238 14
28 COSM105684805 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 14
29 COSM112308171 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 14
30 COSM145026448 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.287G>T p.C96F 17:7675208-7675208 14
31 COSM121934113 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.310T>C p.Y104H 17:7674257-7674257 14
32 COSM143370962 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.736G>A p.E246K 17:7673767-7673767 14
33 COSM144093313 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.-74G>T p.? 17:7675208-7675208 14
34 COSM144021843 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.371G>T p.C124F 17:7675208-7675208 14
35 COSM93183725 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 14
36 COSM105627860 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.725G>T p.C242F 17:7674238-7674238 14
37 COSM87906616 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.725G>T p.C242F 17:7674238-7674238 14
38 COSM121884866 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.329G>T p.C110F 17:7674238-7674238 14
39 COSM111812818 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 14
40 COSM143943874 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.376G>A p.E126K 17:7673767-7673767 14
41 COSM144315997 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.608G>T p.C203F 17:7674238-7674238 14
42 COSM142615001 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.589T>C p.Y197H 17:7674257-7674257 14
43 COSM143993833 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.229T>C p.Y77H 17:7674257-7674257 14
44 COSM143204251 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.229T>C p.Y77H 17:7674257-7674257 14
45 COSM144310279 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.736G>A p.E246K 17:7673767-7673767 14
46 COSM144317156 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.287G>T p.C96F 17:7675208-7675208 14
47 COSM122740814 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.329G>T p.C110F 17:7674238-7674238 14
48 COSM143379946 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.287G>T p.C96F 17:7675208-7675208 14
49 COSM142881780 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.706T>C p.Y236H 17:7674257-7674257 14
50 COSM111767835 TP53 eye,conjunctiva,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 14

Expression for Conjunctival Squamous Cell Carcinoma

Search GEO for disease gene expression data for Conjunctival Squamous Cell Carcinoma.

Pathways for Conjunctival Squamous Cell Carcinoma

Pathways related to Conjunctival Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.51 TP53 CDKN2A CD4
2 10.6 TP53 CDKN2A
3
Show member pathways
10.26 TP53 CDKN2A
4 9.85 TP53 CDKN2A

GO Terms for Conjunctival Squamous Cell Carcinoma

Biological processes related to Conjunctival Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epithelial cell differentiation GO:0030855 9.1 KRT3 KRT15 KRT12

Sources for Conjunctival Squamous Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....