MCID: CNJ007
MIFTS: 39

Conjunctivochalasis

Categories: Eye diseases

Aliases & Classifications for Conjunctivochalasis

MalaCards integrated aliases for Conjunctivochalasis:

Name: Conjunctivochalasis 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4250
ICD9CM 36 372.81
ICD10 34 H11.82
UMLS 74 C0878693

Summaries for Conjunctivochalasis

MalaCards based summary : Conjunctivochalasis is related to superior limbic keratoconjunctivitis and pulmonary emphysema. An important gene associated with Conjunctivochalasis is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Hyaluronic acid and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Conjunctivochalasis is a common eye surface condition characterized by the presence of excess folds of... more...

Related Diseases for Conjunctivochalasis

Diseases related to Conjunctivochalasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 superior limbic keratoconjunctivitis 30.3 MMP1 MMP3
2 pulmonary emphysema 29.8 MMP1 TIMP1 TIMP2
3 refractive error 29.6 MMP2 TIMP1 TIMP2
4 tendinopathy 10.2 MMP1 MMP3
5 adult astrocytic tumour 10.2 MMP1 MMP3
6 gingival hypertrophy 10.2 MMP3 TIMP2
7 epidermolysis bullosa dystrophica 10.2 MMP1 MMP3
8 lipodermatosclerosis 10.2 MMP1 TIMP2
9 periodontitis, chronic 10.2 IL1B MMP1
10 frozen shoulder 10.2 IL1B MMP3
11 coronary artery aneurysm 10.2 MMP1 MMP3
12 kashin-beck disease 10.2 IL1B MMP1
13 hydrarthrosis 10.1 IL1B MMP3
14 fungal keratitis 10.1 TIMP1 TIMP2
15 pulpitis 10.1 IL1B MMP1
16 dupuytren contracture 10.1 IL1B TIMP2
17 fibromatosis, gingival, 1 10.1 MMP1 MMP2
18 internal hemorrhoid 10.1 MMP1 MMP2
19 chronic venous insufficiency 10.1 MMP1 TIMP1
20 light chain deposition disease 10.1 MMP1 MMP2
21 oral lichen planus 10.1 MMP1 TIMP2
22 venous insufficiency 10.1 MMP1 TIMP1
23 odontogenic myxoma 10.1 MMP1 MMP2
24 septic arthritis 10.1 MMP2 MMP3
25 bone structure disease 10.1 IL1B MMP3
26 eumycotic mycetoma 10.1 IL1B TIMP1
27 conjunctival nevus 10.0 MMP2 TIMP1
28 central nervous system tuberculosis 10.0 IL1B TIMP1
29 hypertrophic scars 10.0 MMP2 TIMP1
30 aortic aneurysm, familial thoracic 1 10.0 MMP1 MMP2
31 lung giant cell carcinoma 10.0 MMP2 TIMP1
32 hypertensive heart disease 10.0 MMP1 MMP2
33 vitreoretinopathy, neovascular inflammatory 10.0 TIMP1 TIMP2
34 autoimmune disease 10.0
35 glaucoma, primary open angle 10.0
36 lacrimal duct defect 10.0
37 aging 10.0
38 autoimmune disease 1 10.0
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
40 cataract 10.0
41 sleep apnea 10.0
42 open-angle glaucoma 10.0
43 pinguecula 10.0
44 ehlers-danlos syndrome 10.0
45 cutis laxa 10.0
46 keratoconjunctivitis 10.0
47 arthritis 10.0 IL1B MMP1 MMP3
48 buerger disease 10.0 MMP3 PLAU
49 corneal edema 10.0 IL1B MMP1 MMP3
50 tendinosis 10.0 MMP1 MMP3 TIMP1

Graphical network of the top 20 diseases related to Conjunctivochalasis:



Diseases related to Conjunctivochalasis

Symptoms & Phenotypes for Conjunctivochalasis

MGI Mouse Phenotypes related to Conjunctivochalasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 IL1B MMP2 MMP3 PLAU TIMP1 TIMP2
2 homeostasis/metabolism MP:0005376 9.8 IL1B MMP1 MMP2 MMP3 PLAU TIMP1
3 immune system MP:0005387 9.7 IL1B MMP1 MMP2 MMP3 PLAU TIMP1
4 neoplasm MP:0002006 9.35 IL1B MMP1 MMP2 PLAU TIMP1
5 skeleton MP:0005390 9.02 IL1B MMP2 MMP3 PLAU TIMP1

Drugs & Therapeutics for Conjunctivochalasis

Drugs for Conjunctivochalasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
2 Ophthalmic Solutions Phase 2
3 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Conjunctivochalasis Completed NCT02810119 Phase 2 LO2A;Placebo
2 Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Moderate to Severe Conjunctivochalasis Recruiting NCT02804191 Phase 2 LO2A;Saline
3 The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327
4 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. Unknown status NCT02849093
5 Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis Completed NCT01933178 Not Applicable
6 Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease Completed NCT03364322

Search NIH Clinical Center for Conjunctivochalasis

Genetic Tests for Conjunctivochalasis

Anatomical Context for Conjunctivochalasis

MalaCards organs/tissues related to Conjunctivochalasis:

42
Eye, Bone, T Cells, Testes, Thyroid, Heart, Lymph Node

Publications for Conjunctivochalasis

Articles related to Conjunctivochalasis:

(show top 50) (show all 100)
# Title Authors Year
1
Evaluation of Subconjunctival Remnant Particles after High-frequency Radio-wave Electrosurgery for Conjunctivochalasis. ( 30746907 )
2019
2
Comparative transcriptome analysis of human conjunctiva between normal and conjunctivochalasis persons by RNA sequencing. ( 30999002 )
2019
3
Medical and surgical management of conjunctivochalasis. ( 31009751 )
2019
4
The Presence of Conjunctivochalasis in Obstructive Sleep Apnea Patients. ( 28099284 )
2018
5
Conjunctivochalasis and Related Factors in an Adult Population of Iran. ( 28346280 )
2018
6
Factors that influence tear meniscus area and conjunctivochalasis: The Singapore Indian eye study. ( 28910571 )
2018
7
Conjunctivochalasis: a systematic review. ( 29128574 )
2018
8
The Location of Conjunctivochalasis and Its Clinical Correlation with the Severity of Dry Eye Symptoms. ( 29361769 )
2018
9
A Quick Surgical Treatment of Conjunctivochalasis Using Radiofrequencies. ( 29439532 )
2018
10
Comparison of Electrocoagulation and Conventional Medical Drops for Treatment of Conjunctivochalasis: Short-Term Results. ( 29755817 )
2018
11
A preliminary study on the establishment of an animal model of conjunctivochalasis. ( 29977798 )
2018
12
Investigation of conjunctivochalasis histopathology with light and electron microscopy in patients with conjunctivochalasis in different locations. ( 29987706 )
2018
13
Trends in conjunctivochalasis research from 1986 to 2017: A bibliometric analysis. ( 30278590 )
2018
14
Changes of conjunctivochalasis after cataract surgery via a superior transconjunctival sclerocorneal incision. ( 27573450 )
2017
15
Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis. ( 28503427 )
2017
16
Surgical techniques for the treatment of conjunctivochalasis: paste-pinch-cut conjunctivoplasty versus thermal cautery conjunctivoplasty. ( 28576214 )
2017
17
The role of elastic fibers in pathogenesis of conjunctivochalasis. ( 28944209 )
2017
18
Management of incision failure during small incision lenticule extraction because of conjunctivochalasis. ( 29260098 )
2017
19
Restoration of Fornix Tear Reservoir in Conjunctivochalasis With Fornix Reconstruction. ( 26890668 )
2016
20
A New Surgical Approach for the Treatment of Conjunctivochalasis: Reduction of the Conjunctival Fold with Bipolar Electrocautery Forceps. ( 27200408 )
2016
21
The treatment outcomes of crescent-shaped conjunctiva resection combined with conjunctiva sclera fixation for severe conjunctivochalasis. ( 27649649 )
2016
22
Evaluation of the Effects of Conjunctivochalasis Excision on Tear Stability and Contrast Sensitivity. ( 27892479 )
2016
23
Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva. ( 27994801 )
2016
24
The impact of conjunctivochalasis on dry eye symptoms and signs. ( 26024073 )
2015
25
Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study. ( 26172053 )
2015
26
Change in Tear Film Lipid Layer Thickness, Corneal Thickness, Volume and Topography after Superficial Cauterization for Conjunctivochalasis. ( 26184418 )
2015
27
Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. ( 26265227 )
2015
28
Correlation Between Recurrent Subconjunctival Hemorrhages and Conjunctivochalasis by Clinical Profile and Successful Surgical Outcome. ( 26269933 )
2015
29
Real-world assessment of diquafosol in dry eye patients with risk factors such as contact lens, meibomian gland dysfunction, and conjunctivochalasis: subgroup analysis from a prospective observational study. ( 26664039 )
2015
30
Treatment of symptomatic inferior conjunctivochalasis by ligation. ( 24520953 )
2014
31
The influence of glaucoma medications on ocular surface disease in primary open-angle glaucoma patients with and without conjunctivochalasis. ( 24774884 )
2014
32
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. ( 24962763 )
2014
33
Re: "Medial conjunctival resection for tearing associated with conjunctivochalasis". ( 25069074 )
2014
34
Reply re: "Medial conjunctival resection for tearing associated with conjunctivochalasis". ( 25069075 )
2014
35
Clinical characteristics of patients with conjunctivochalasis. ( 25210435 )
2014
36
Impact of conjunctivochalasis on visual quality of life: a community population survey. ( 25330252 )
2014
37
Conjunctivochalasis as a contributing factor for the development of ocular surface disease in medically treated glaucoma patients. ( 23377585 )
2014
38
Influence of axial length on conjunctivochalasis. ( 23665652 )
2013
39
Medial conjunctival resection for tearing associated with conjunctivochalasis. ( 23787958 )
2013
40
Comparison study of two diagnostic and grading systems for conjunctivochalasis. ( 23981623 )
2013
41
Conjunctivochalasis is the precursor to pterygium. ( 24053977 )
2013
42
Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis. ( 24255042 )
2013
43
New approach for conjunctivochalasis using an argon green laser. ( 22929155 )
2013
44
Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography. ( 23036571 )
2013
45
The effect of age and conjunctivochalasis on conjunctival thickness. ( 23249375 )
2013
46
Simultaneous treatment of pterygium and temporal conjunctivochalasis. ( 23470810 )
2013
47
Conjunctivochalasis interferes with tear flow from fornix to tear meniscus. ( 23583167 )
2013
48
Conjunctivochalasis: associations with pinguecula in a hospital-based study. ( 21518307 )
2012
49
Increased tear osmolarity in patients with severe cases of conjunctivochalasis. ( 22050557 )
2012
50
Thermocautery for inferior conjunctivochalasis. ( 22245977 )
2012

Variations for Conjunctivochalasis

Expression for Conjunctivochalasis

Search GEO for disease gene expression data for Conjunctivochalasis.

Pathways for Conjunctivochalasis

Pathways related to Conjunctivochalasis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 IL1B MMP1 MMP2 MMP3 PLAU TIMP1
2
Show member pathways
13.4 MMP1 MMP2 MMP3 TIMP1 TIMP2
3
Show member pathways
13.04 IL1B MMP1 MMP2 MMP3 TIMP1
4
Show member pathways
12.48 MMP1 MMP2 MMP3 TIMP1 TIMP2
5
Show member pathways
12.43 IL1B TIMP1 TIMP2
6
Show member pathways
12.32 IL1B MMP2 TIMP1
7
Show member pathways
12.08 IL1B MMP1 MMP3
8
Show member pathways
12.02 MMP1 MMP3 TIMP1
9
Show member pathways
12 IL1B TIMP1 TIMP2
10
Show member pathways
11.95 IL1B MMP1 MMP2 MMP3
11
Show member pathways
11.82 IL1B TIMP1 TIMP2
12
Show member pathways
11.8 IL1B MMP2 MMP3
13 11.63 IL1B MMP1 MMP3
14 11.62 MMP2 MMP3 TIMP1 TIMP2
15 11.61 IL1B MMP1 MMP2 MMP3 TIMP1
16 11.51 MMP1 MMP2
17 11.49 IL1B MMP3
18 11.42 IL1B MMP2 PLAU TIMP1
19 11.36 MMP2 PLAU
20
Show member pathways
11.36 IL1B MMP1 MMP2 MMP3
21
Show member pathways
11.35 MMP1 MMP2 MMP3 TIMP1 TIMP2
22 11.3 IL1B TIMP1
23 11.28 MMP2 PLAU
24
Show member pathways
11.24 MMP2 PLAU
25 11.24 MMP1 MMP3 TIMP2
26 11.16 MMP1 MMP2 PLAU
27 10.98 IL1B TIMP1 TIMP2
28 10.89 MMP1 MMP2
29 10.89 MMP1 MMP2 MMP3 PLAU TIMP1 TIMP2
30 10.84 MMP1 TIMP1

GO Terms for Conjunctivochalasis

Cellular components related to Conjunctivochalasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 IL1B MMP2 MMP3 PLAU TIMP1 TIMP2
2 extracellular region GO:0005576 9.5 IL1B MMP1 MMP2 MMP3 PLAU TIMP1
3 extracellular matrix GO:0031012 9.02 MMP1 MMP2 MMP3 TIMP1 TIMP2

Biological processes related to Conjunctivochalasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.76 MMP1 MMP2 MMP3 PLAU
2 regulation of signaling receptor activity GO:0010469 9.71 IL1B PLAU TIMP1
3 cellular protein metabolic process GO:0044267 9.61 MMP1 MMP2 TIMP1
4 response to cytokine GO:0034097 9.52 TIMP1 TIMP2
5 response to hormone GO:0009725 9.51 TIMP1 TIMP2
6 embryo implantation GO:0007566 9.48 IL1B MMP2
7 collagen catabolic process GO:0030574 9.43 MMP1 MMP2 MMP3
8 positive regulation of protein oligomerization GO:0032461 9.4 MMP1 MMP3
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.37 TIMP1 TIMP2
10 cytokine-mediated signaling pathway GO:0019221 9.35 IL1B MMP1 MMP2 MMP3 TIMP1
11 negative regulation of metallopeptidase activity GO:1905049 9.32 TIMP1 TIMP2
12 response to peptide hormone GO:0043434 9.19 TIMP1
13 response to hypoxia GO:0001666 9.16 MMP2 PLAU
14 extracellular matrix disassembly GO:0022617 9.02 MMP1 MMP2 MMP3 TIMP1 TIMP2

Molecular functions related to Conjunctivochalasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.56 MMP1 MMP2 MMP3 PLAU
2 metallopeptidase activity GO:0008237 9.54 MMP1 MMP2 MMP3
3 enzyme inhibitor activity GO:0004857 9.4 TIMP1 TIMP2
4 zinc ion binding GO:0008270 9.35 MMP1 MMP2 MMP3 TIMP1 TIMP2
5 metalloendopeptidase activity GO:0004222 9.33 MMP1 MMP2 MMP3
6 metalloendopeptidase inhibitor activity GO:0008191 9.32 TIMP1 TIMP2
7 serine-type endopeptidase activity GO:0004252 8.92 MMP1 MMP2 MMP3 PLAU

Sources for Conjunctivochalasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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