MCID: CNJ007
MIFTS: 39

Conjunctivochalasis

Categories: Eye diseases

Aliases & Classifications for Conjunctivochalasis

MalaCards integrated aliases for Conjunctivochalasis:

Name: Conjunctivochalasis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4250
ICD10 33 H11.82
ICD9CM 35 372.81
UMLS 73 C0878693

Summaries for Conjunctivochalasis

MalaCards based summary : Conjunctivochalasis is related to superior limbic keratoconjunctivitis and pulmonary emphysema. An important gene associated with Conjunctivochalasis is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Hyaluronic acid and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Conjunctivochalasis is a common eye surface condition characterized by the presence of excess folds of... more...

Related Diseases for Conjunctivochalasis

Diseases related to Conjunctivochalasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 superior limbic keratoconjunctivitis 30.1 MMP1 MMP3
2 pulmonary emphysema 29.7 MMP1 TIMP1 TIMP2
3 refractive error 29.5 MMP2 TIMP1 TIMP2
4 tendinopathy 10.1 MMP1 MMP3
5 adult astrocytic tumour 10.1 MMP1 MMP3
6 corneal edema 10.1 MMP1 MMP3
7 epidermolysis bullosa dystrophica 10.1 MMP1 MMP3
8 gingival hypertrophy 10.1 MMP3 TIMP2
9 coronary artery aneurysm 10.1 MMP1 MMP3
10 lymph node disease 10.1 MMP1 MMP3
11 buerger disease 10.1 MMP3 PLAU
12 lipodermatosclerosis 10.1 MMP1 TIMP2
13 synovitis 10.0 MMP1 MMP3
14 oral lichen planus 10.0 MMP1 TIMP2
15 bone deterioration disease 10.0 MMP3 TIMP1
16 preterm premature rupture of the membranes 10.0 MMP1 TIMP2
17 gingival disease 10.0 MMP1 TIMP1
18 chronic venous insufficiency 10.0 MMP1 TIMP1
19 fungal keratitis 10.0 TIMP1 TIMP2
20 venous insufficiency 10.0 MMP1 TIMP1
21 corneal ulcer 10.0 MMP2 MMP3
22 vitreoretinopathy, neovascular inflammatory 10.0 TIMP1 TIMP2
23 fibromatosis, gingival, 1 10.0 MMP1 MMP2
24 internal hemorrhoid 10.0 MMP1 MMP2
25 light chain deposition disease 10.0 MMP1 MMP2
26 odontogenic myxoma 10.0 MMP1 MMP2
27 kawasaki disease 9.9 MMP3 TIMP1
28 hypertensive heart disease 9.9 MMP1 MMP2
29 autoimmune disease 9.9
30 glaucoma, primary open angle 9.9
31 lacrimal duct defect 9.9
32 aging 9.9
33 autoimmune disease 1 9.9
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
35 cataract 9.9
36 sleep apnea 9.9
37 open-angle glaucoma 9.9
38 pinguecula 9.9
39 ehlers-danlos syndrome 9.9
40 cutis laxa 9.9
41 keratoconjunctivitis 9.9
42 aortic aneurysm, familial thoracic 1 9.9 MMP1 MMP2
43 pneumothorax 9.9 MMP1 MMP2
44 conjunctival nevus 9.9 MMP2 TIMP1
45 tendinosis 9.9 MMP1 MMP3 TIMP1
46 carotid artery disease 9.9 MMP1 MMP3 TIMP1
47 hypertrophic scars 9.9 MMP2 TIMP1
48 bone inflammation disease 9.9 MMP1 MMP3 TIMP1
49 osteoarthritis 9.9 MMP1 MMP3 TIMP1
50 lymphangioleiomyomatosis 9.9 MMP1 MMP2

Graphical network of the top 20 diseases related to Conjunctivochalasis:



Diseases related to Conjunctivochalasis

Symptoms & Phenotypes for Conjunctivochalasis

MGI Mouse Phenotypes related to Conjunctivochalasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 MMP2 MMP3 PLAU TIMP1 TIMP2
2 homeostasis/metabolism MP:0005376 9.63 MMP1 MMP2 MMP3 PLAU TIMP1 TIMP2
3 immune system MP:0005387 9.43 MMP1 MMP2 MMP3 PLAU TIMP1 TIMP2
4 neoplasm MP:0002006 8.92 MMP1 MMP2 PLAU TIMP1

Drugs & Therapeutics for Conjunctivochalasis

Drugs for Conjunctivochalasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
2 Ophthalmic Solutions Phase 2
3 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 To Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Conjunctivochalasis Completed NCT02810119 Phase 2 LO2A;Placebo
2 Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Moderate to Severe Conjunctivochalasis Recruiting NCT02804191 Phase 2 LO2A;Saline
3 The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327
4 Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. Unknown status NCT02849093
5 Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis Completed NCT01933178 Not Applicable
6 Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease Completed NCT03364322

Search NIH Clinical Center for Conjunctivochalasis

Genetic Tests for Conjunctivochalasis

Anatomical Context for Conjunctivochalasis

MalaCards organs/tissues related to Conjunctivochalasis:

41
Eye, Lung, Bone, Heart, Lymph Node, Breast, T Cells

Publications for Conjunctivochalasis

Articles related to Conjunctivochalasis:

(show top 50) (show all 96)
# Title Authors Year
1
A Quick Surgical Treatment of Conjunctivochalasis Using Radiofrequencies. ( 29439532 )
2018
2
A preliminary study on the establishment of an animal model of conjunctivochalasis. ( 29977798 )
2018
3
The Location of Conjunctivochalasis and Its Clinical Correlation with the Severity of Dry Eye Symptoms. ( 29361769 )
2018
4
Comparison of Electrocoagulation and Conventional Medical Drops for Treatment of Conjunctivochalasis: Short-Term Results. ( 29755817 )
2018
5
Investigation of conjunctivochalasis histopathology with light and electron microscopy in patients with conjunctivochalasis in different locations. ( 29987706 )
2018
6
Trends in conjunctivochalasis research from 1986 to 2017: A bibliometric analysis. ( 30278590 )
2018
7
The role of elastic fibers in pathogenesis of conjunctivochalasis. ( 28944209 )
2017
8
Management of incision failure during small incision lenticule extraction because of conjunctivochalasis. ( 29260098 )
2017
9
Surgical techniques for the treatment of conjunctivochalasis: paste-pinch-cut conjunctivoplasty versus thermal cautery conjunctivoplasty. ( 28576214 )
2017
10
Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis. ( 28503427 )
2017
11
Factors that influence tear meniscus area and conjunctivochalasis: The Singapore Indian eye study. ( 28910571 )
2017
12
The Presence of Conjunctivochalasis in Obstructive Sleep Apnea Patients. ( 28099284 )
2017
13
Conjunctivochalasis: a systematic review. ( 29128574 )
2017
14
Conjunctivochalasis and Related Factors in an Adult Population of Iran. ( 28346280 )
2017
15
Restoration of Fornix Tear Reservoir in Conjunctivochalasis With Fornix Reconstruction. ( 26890668 )
2016
16
The treatment outcomes of crescent-shaped conjunctiva resection combined with conjunctiva sclera fixation for severe conjunctivochalasis. ( 27649649 )
2016
17
Changes of conjunctivochalasis after cataract surgery via a superior transconjunctival sclerocorneal incision. ( 27573450 )
2016
18
Evaluation of the Effects of Conjunctivochalasis Excision on Tear Stability and Contrast Sensitivity. ( 27892479 )
2016
19
A New Surgical Approach for the Treatment of Conjunctivochalasis: Reduction of the Conjunctival Fold with Bipolar Electrocautery Forceps. ( 27200408 )
2016
20
Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva. ( 27994801 )
2016
21
Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study. ( 26172053 )
2015
22
The impact of conjunctivochalasis on dry eye symptoms and signs. ( 26024073 )
2015
23
Correlation Between Recurrent Subconjunctival Hemorrhages and Conjunctivochalasis by Clinical Profile and Successful Surgical Outcome. ( 26269933 )
2015
24
Change in Tear Film Lipid Layer Thickness, Corneal Thickness, Volume and Topography after Superficial Cauterization for Conjunctivochalasis. ( 26184418 )
2015
25
Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. ( 26265227 )
2015
26
Real-world assessment of diquafosol in dry eye patients with risk factors such as contact lens, meibomian gland dysfunction, and conjunctivochalasis: subgroup analysis from a prospective observational study. ( 26664039 )
2015
27
Re: "Medial conjunctival resection for tearing associated with conjunctivochalasis". ( 25069074 )
2014
28
Reply re: "Medial conjunctival resection for tearing associated with conjunctivochalasis". ( 25069075 )
2014
29
Treatment of symptomatic inferior conjunctivochalasis by ligation. ( 24520953 )
2014
30
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. ( 24962763 )
2014
31
Clinical characteristics of patients with conjunctivochalasis. ( 25210435 )
2014
32
The influence of glaucoma medications on ocular surface disease in primary open-angle glaucoma patients with and without conjunctivochalasis. ( 24774884 )
2014
33
Impact of conjunctivochalasis on visual quality of life: a community population survey. ( 25330252 )
2014
34
Conjunctivochalasis as a Contributing Factor for the Development of Ocular Surface Disease in Medically Treated Glaucoma Patients. ( 23377585 )
2013
35
Medial conjunctival resection for tearing associated with conjunctivochalasis. ( 23787958 )
2013
36
Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography. ( 23036571 )
2013
37
Conjunctivochalasis interferes with tear flow from fornix to tear meniscus. ( 23583167 )
2013
38
New approach for conjunctivochalasis using an argon green laser. ( 22929155 )
2013
39
Comparison study of two diagnostic and grading systems for conjunctivochalasis. ( 23981623 )
2013
40
Simultaneous treatment of pterygium and temporal conjunctivochalasis. ( 23470810 )
2013
41
Influence of axial length on conjunctivochalasis. ( 23665652 )
2013
42
Tear MMP-9 levels as a marker of ocular surface inflammation in conjunctivochalasis. ( 24255042 )
2013
43
Conjunctivochalasis is the precursor to pterygium. ( 24053977 )
2013
44
The effect of age and conjunctivochalasis on conjunctival thickness. ( 23249375 )
2013
45
An improved surgical method to correct conjunctivochalasis: conjunctival semiperitomy based on corneal limbus with subconjunctival cauterization. ( 23036542 )
2012
46
TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis. ( 22297496 )
2012
47
Severe conjunctivochalasis in association with classic type Ehlers-Danlos syndrome. ( 22943506 )
2012
48
Thermocautery for inferior conjunctivochalasis. ( 22245977 )
2012
49
New approach for conjunctivochalasis with argon laser photocoagulation. ( 22883849 )
2012
50
PTX3 controls activation of matrix metalloproteinase 1 and apoptosis in conjunctivochalasis fibroblasts. ( 22511625 )
2012

Variations for Conjunctivochalasis

Expression for Conjunctivochalasis

Search GEO for disease gene expression data for Conjunctivochalasis.

Pathways for Conjunctivochalasis

Pathways related to Conjunctivochalasis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 MMP1 MMP2 MMP3 PLAU TIMP1 TIMP2
2
Show member pathways
13.32 MMP1 MMP2 MMP3 TIMP1 TIMP2
3
Show member pathways
13.03 MMP1 MMP2 MMP3 PLAU
4
Show member pathways
12.99 MMP1 MMP2 MMP3 TIMP1
5
Show member pathways
12.37 MMP1 MMP2 MMP3 TIMP1 TIMP2
6
Show member pathways
11.94 MMP1 MMP3 TIMP1
7
Show member pathways
11.89 MMP1 MMP2 MMP3
8 11.61 MMP1 MMP2 MMP3 TIMP1
9 11.56 MMP1 MMP3
10 11.46 MMP1 MMP2
11 11.43 MMP2 PLAU TIMP1
12
Show member pathways
11.41 MMP1 MMP2 MMP3
13 11.41 MMP2 MMP3 TIMP1 TIMP2
14
Show member pathways
11.35 MMP1 MMP2 MMP3 TIMP1 TIMP2
15 11.32 MMP2 PLAU
16 11.25 MMP2 PLAU
17
Show member pathways
11.21 MMP2 PLAU
18 11.17 MMP1 MMP3 TIMP2
19 11.08 MMP1 MMP2 PLAU
20 10.93 TIMP1 TIMP2
21 10.89 MMP1 MMP2 MMP3 PLAU TIMP1 TIMP2
22 10.82 MMP1 MMP2
23 10.76 MMP1 TIMP1

GO Terms for Conjunctivochalasis

Cellular components related to Conjunctivochalasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 MMP2 MMP3 PLAU TIMP1 TIMP2
2 extracellular region GO:0005576 9.43 MMP1 MMP2 MMP3 PLAU TIMP1 TIMP2
3 extracellular matrix GO:0031012 9.02 MMP1 MMP2 MMP3 TIMP1 TIMP2

Biological processes related to Conjunctivochalasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.73 MMP1 MMP2 MMP3 PLAU
2 cellular protein metabolic process GO:0044267 9.63 MMP1 MMP2 TIMP1
3 response to hypoxia GO:0001666 9.58 MMP2 MMP3 PLAU
4 response to organic substance GO:0010033 9.51 TIMP1 TIMP2
5 response to cytokine GO:0034097 9.49 TIMP1 TIMP2
6 response to hormone GO:0009725 9.48 TIMP1 TIMP2
7 cytokine-mediated signaling pathway GO:0019221 9.46 MMP1 MMP2 MMP3 TIMP1
8 positive regulation of protein oligomerization GO:0032461 9.37 MMP1 MMP3
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.32 TIMP1 TIMP2
10 negative regulation of metallopeptidase activity GO:1905049 9.26 TIMP1 TIMP2
11 collagen catabolic process GO:0030574 9.13 MMP1 MMP2 MMP3
12 extracellular matrix disassembly GO:0022617 9.02 MMP1 MMP2 MMP3 TIMP1 TIMP2

Molecular functions related to Conjunctivochalasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.78 MMP1 MMP2 MMP3 PLAU
2 peptidase activity GO:0008233 9.56 MMP1 MMP2 MMP3 PLAU
3 metallopeptidase activity GO:0008237 9.5 MMP1 MMP2 MMP3
4 protease binding GO:0002020 9.46 TIMP1 TIMP2
5 endopeptidase activity GO:0004175 9.43 MMP1 MMP3
6 enzyme inhibitor activity GO:0004857 9.4 TIMP1 TIMP2
7 metalloendopeptidase inhibitor activity GO:0008191 9.37 TIMP1 TIMP2
8 zinc ion binding GO:0008270 9.35 MMP1 MMP2 MMP3 TIMP1 TIMP2
9 metalloendopeptidase activity GO:0004222 9.33 MMP1 MMP2 MMP3
10 serine-type endopeptidase activity GO:0004252 8.92 MMP1 MMP2 MMP3 PLAU

Sources for Conjunctivochalasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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