MCID: CNJ007
MIFTS: 38

Conjunctivochalasis

Categories: Eye diseases

Aliases & Classifications for Conjunctivochalasis

MalaCards integrated aliases for Conjunctivochalasis:

Name: Conjunctivochalasis 12 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4250
ICD9CM 34 372.81
ICD10 32 H11.82
UMLS 71 C0878693

Summaries for Conjunctivochalasis

MalaCards based summary : Conjunctivochalasis is related to superior limbic keratoconjunctivitis and sleep apnea. An important gene associated with Conjunctivochalasis is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Dipivefrin and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Conjunctivochalasis is a common eye surface condition characterized by the presence of excess folds of... more...

Related Diseases for Conjunctivochalasis

Diseases related to Conjunctivochalasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 superior limbic keratoconjunctivitis 31.0 MMP3 MMP1
2 sleep apnea 29.7 IL6 IL1B CXCL8
3 keratoconjunctivitis 29.6 MMP9 IL6 CXCL8
4 conjunctivitis 29.6 MMP9 IL6 CXCL8
5 cutis laxa 29.4 MMP9 MMP3 MMP2 MMP1
6 blepharitis 29.3 MMP9 IL6 CXCL8
7 keratitis, hereditary 29.3 MMP9 IL6 IL1B CXCL8
8 corneal disease 28.9 MMP9 IL6 IL1B CXCL8
9 autoimmune disease 28.8 MMP9 IL6 IL1B CXCL8
10 refractive error 28.8 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
11 eye disease 28.5 MMP9 MMP2 MMP1 IL6 IL1B CXCL8
12 pulmonary emphysema 28.5 TIMP2 TIMP1 MMP9 MMP2 MMP1 CXCL8
13 tendinopathy 10.5 MMP3 MMP1
14 lipodermatosclerosis 10.4 TIMP2 MMP1
15 fibromatosis, gingival, 1 10.4 MMP2 MMP1
16 dentin caries 10.4 MMP3 MMP2
17 pinguecula 10.3
18 posterolateral myocardial infarction 10.3 MMP3 MMP2
19 hypertrophic scars 10.3 TIMP1 MMP2
20 dupuytren contracture 10.3 TIMP2 IL1B
21 tendinosis 10.3 TIMP1 MMP3 MMP1
22 lacrimal duct defect 10.2
23 punctate epithelial keratoconjunctivitis 10.2
24 ectropion 10.2
25 cataract 10.2
26 lymphangiectasis 10.2
27 prosthetic joint infection 10.2 IL6 IL1B
28 osteosclerotic myeloma 10.2 IL6 IL1B
29 uremic pruritus 10.2 IL6 IL1B
30 indolent myeloma 10.2 IL6 IL1B
31 corneal edema 10.2 MMP3 MMP1 IL1B
32 angelucci's syndrome 10.2 IL1B CXCL8
33 dermatitis, atopic, 8 10.2 IL1B CXCL8
34 esophagus melanoma 10.2 IL1B CXCL8
35 stachybotrys chartarum 10.2 IL6 IL1B
36 eales disease 10.2 IL6 IL1B
37 idiopathic anterior uveitis 10.2 IL6 CXCL8
38 frozen shoulder 10.2 MMP3 MMP2 IL1B
39 intraocular pressure quantitative trait locus 10.2
40 dry eye syndrome 10.2
41 entropion 10.2
42 streptococcal toxic-shock syndrome 10.2 IL6 CXCL8
43 lymph node disease 10.1 MMP3 MMP1 IL6
44 chronic ulcer of skin 10.1 TIMP2 MMP1 IL6
45 fuchs' heterochromic uveitis 10.1 IL6 CXCL8
46 rheumatoid nodulosis 10.1 MMP9 MMP3
47 chondrosarcoma 10.1 PLAU MMP3 MMP1
48 post-cardiac arrest syndrome 10.1 IL6 CXCL8
49 idiopathic neutropenia 10.1 IL6 IL1B
50 laryngitis 10.1 IL6 IL1B

Graphical network of the top 20 diseases related to Conjunctivochalasis:



Diseases related to Conjunctivochalasis

Symptoms & Phenotypes for Conjunctivochalasis

MGI Mouse Phenotypes related to Conjunctivochalasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 IL1B IL6 MMP2 MMP3 MMP9 PLAU
2 immune system MP:0005387 9.81 IL1B IL6 MMP1 MMP2 MMP3 MMP9
3 neoplasm MP:0002006 9.5 IL1B IL6 MMP1 MMP2 MMP9 PLAU
4 skeleton MP:0005390 9.17 IL1B IL6 MMP2 MMP3 MMP9 PLAU

Drugs & Therapeutics for Conjunctivochalasis

Drugs for Conjunctivochalasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4 52365-63-6 3105
2 Pharmaceutical Solutions Phase 4
3 Ophthalmic Solutions Phase 4
4 Lubricant Eye Drops Phase 4
5 Guar Phase 4
6
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Ocular Surface Lubricant Eyedrops on Lid Parallel Conjunctival Folds (LIPCOF) and Other Signs and Symptoms of Dysfunctional Tear Syndrome Completed NCT01268735 Phase 4 Lubricating eyedrops containing hydroxypropyl-guar
2 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multi-Center Study to Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Moderate to Severe Conjunctivochalasis Unknown status NCT02804191 Phase 2 LO2A;Saline
3 A Randomized, Double-Blind, Placebo-Controlled, Pilot Study to Evaluate the Efficacy and Safety of LO2A Eye Drops in Patients With Moderate to Severe Conjunctivochalasis Completed NCT02810119 Phase 2 LO2A;Placebo
4 The Role of Cytokines and Mast Cell in the Pathogenesis of Ocular Surface Inflammation Diseases Including Superior Limbic Keratoconjunctivitis, Conjunctivochalasis, and Dry Eye Unknown status NCT02160327
5 Inter and Intra Examiner Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis Completed NCT01933178
6 Long-term Observation of Tear Proteomic Profiles and Ocular Surface in Trabeculectomy Patients Before and After Surgery Completed NCT01841580

Search NIH Clinical Center for Conjunctivochalasis

Genetic Tests for Conjunctivochalasis

Anatomical Context for Conjunctivochalasis

MalaCards organs/tissues related to Conjunctivochalasis:

40
Eye, Bone, Lung, Heart, Liver, Thyroid, Brain

Publications for Conjunctivochalasis

Articles related to Conjunctivochalasis:

(show top 50) (show all 146)
# Title Authors PMID Year
1
The role of oxidative stress and inflammation in conjunctivochalasis. 54 61
20019361 2010
2
Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and tumor necrosis factor-alpha. 54 61
10967046 2000
3
Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. 54 61
10670469 2000
4
Meibomian Gland Dysfunction and Dry Eye Are Similar but Different Based on a Population-Based Study: The Hirado-Takushima Study in Japan. 61
30851269 2019
5
P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts. 61
31682715 2019
6
Medical and surgical management of conjunctivochalasis. 61
31009751 2019
7
Investigation of conjunctivochalasis histopathology with light and electron microscopy in patients with conjunctivochalasis in different locations. 61
29987706 2019
8
Comparative transcriptome analysis of human conjunctiva between normal and conjunctivochalasis persons by RNA sequencing. 61
30999002 2019
9
Evaluation of Subconjunctival Remnant Particles after High-frequency Radio-wave Electrosurgery for Conjunctivochalasis. 61
30746907 2019
10
The expression of MAPK signaling pathways in conjunctivochalasis. 61
31741872 2019
11
Combination Surgery of Silicone Tube Intubation and Conjunctival Resection in Patients with Epiphora. 61
30549466 2018
12
The combination of strip meniscometry and dry eye-related quality-of-life score is useful for dry eye screening during health checkup: Cross-sectional study. 61
30412120 2018
13
Trends in conjunctivochalasis research from 1986 to 2017: A bibliometric analysis. 61
30278590 2018
14
The Presence of Conjunctivochalasis in Obstructive Sleep Apnea Patients. 61
28099284 2018
15
Conjunctivochalasis and Related Factors in an Adult Population of Iran. 61
28346280 2018
16
Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye. 61
29459039 2018
17
Conjunctivochalasis: a systematic review. 61
29128574 2018
18
Comparison of Electrocoagulation and Conventional Medical Drops for Treatment of Conjunctivochalasis: Short-Term Results. 61
29755817 2018
19
Near-infrared laser thermal conjunctivoplasty. 61
29497112 2018
20
[Ocular surface aging: Pathophysiology and consequences for management]. 61
29573862 2018
21
A Quick Surgical Treatment of Conjunctivochalasis Using Radiofrequencies. 61
29439532 2018
22
Factors that influence tear meniscus area and conjunctivochalasis: The Singapore Indian eye study. 61
28910571 2018
23
The Location of Conjunctivochalasis and Its Clinical Correlation with the Severity of Dry Eye Symptoms. 61
29361769 2018
24
A preliminary study on the establishment of an animal model of conjunctivochalasis. 61
29977798 2018
25
The proportion of ocular surface diseases in untreated patients with epiphora. 61
30254415 2018
26
Conjunctival Tear Layer Temperature, Evaporation, Hyperosmolarity, Inflammation, Hyperemia, Tissue Damage, and Symptoms: A Review of an Amplifying Cascade. 61
29111837 2017
27
Management of incision failure during small incision lenticule extraction because of conjunctivochalasis. 61
29260098 2017
28
Changes of conjunctivochalasis after cataract surgery via a superior transconjunctival sclerocorneal incision. 61
27573450 2017
29
Surgical techniques for the treatment of conjunctivochalasis: paste-pinch-cut conjunctivoplasty versus thermal cautery conjunctivoplasty. 61
28576214 2017
30
Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis. 61
28503427 2017
31
The role of elastic fibers in pathogenesis of conjunctivochalasis. 61
28944209 2017
32
Evaluation of the Effects of Conjunctivochalasis Excision on Tear Stability and Contrast Sensitivity. 61
27892479 2016
33
Histopathology of Conjunctivochalasis Compared to Normal Conjunctiva. 61
27994801 2016
34
Restoration of Fornix Tear Reservoir in Conjunctivochalasis With Fornix Reconstruction. 61
26890668 2016
35
The treatment outcomes of crescent-shaped conjunctiva resection combined with conjunctiva sclera fixation for severe conjunctivochalasis. 61
27649649 2016
36
A New Surgical Approach for the Treatment of Conjunctivochalasis: Reduction of the Conjunctival Fold with Bipolar Electrocautery Forceps. 61
27200408 2016
37
Correlation Between Recurrent Subconjunctival Hemorrhages and Conjunctivochalasis by Clinical Profile and Successful Surgical Outcome. 61
26269933 2015
38
Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. 61
26255576 2015
39
Simultaneous treatment of pterygium complicated with conjunctivochalasis: analysis of pterygium excision and conjunctival autotransplantation combined with sclera fixation. 61
26265227 2015
40
Change in Tear Film Lipid Layer Thickness, Corneal Thickness, Volume and Topography after Superficial Cauterization for Conjunctivochalasis. 61
26184418 2015
41
The impact of conjunctivochalasis on dry eye symptoms and signs. 61
26024073 2015
42
Real-world assessment of diquafosol in dry eye patients with risk factors such as contact lens, meibomian gland dysfunction, and conjunctivochalasis: subgroup analysis from a prospective observational study. 61
26664039 2015
43
Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study. 61
26172053 2015
44
The BLICK mnemonic for clinical-anatomical assessment of patients with epiphora. 61
25216202 2014
45
The influence of glaucoma medications on ocular surface disease in primary open-angle glaucoma patients with and without conjunctivochalasis. 61
24774884 2014
46
En-face optical coherence tomography as a novel tool for exploring the ocular surface: a pilot comparative study to conventional B-scans and in vivo confocal microscopy. 61
25284774 2014
47
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. 61
24962763 2014
48
[The clinical comparison of conjunctival resection with conjunctival resection and sclera fixation in the treatment of conjunctivochalasis]. 61
25533560 2014
49
Upregulation of Toll-like receptor 5 expression in the conjunctival epithelium of various human ocular surface diseases. 61
24820048 2014
50
Treatment of symptomatic inferior conjunctivochalasis by ligation. 61
24520953 2014

Variations for Conjunctivochalasis

Expression for Conjunctivochalasis

Search GEO for disease gene expression data for Conjunctivochalasis.

Pathways for Conjunctivochalasis

Pathways related to Conjunctivochalasis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TIMP2 TIMP1 PLAU MMP9 MMP3 MMP2
2
Show member pathways
13.74 TIMP2 TIMP1 PLAU MMP9 MMP2 IL6
3
Show member pathways
13.6 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
4
Show member pathways
13.31 PLAU MMP9 MMP3 MMP2 MMP1 CXCL8
5
Show member pathways
13.28 TIMP1 MMP9 MMP3 MMP2 MMP1 IL6
6 12.81 MMP9 MMP2 MMP1 IL6 CXCL8 CALML6
7
Show member pathways
12.71 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
8
Show member pathways
12.63 TIMP2 TIMP1 IL6 IL1B
9
Show member pathways
12.6 MMP9 MMP2 MMP1 CALML6
10
Show member pathways
12.52 TIMP1 MMP2 IL6 IL1B
11
Show member pathways
12.25 TIMP2 TIMP1 IL6 IL1B CXCL8
12 12.23 PLAU MMP9 MMP3 IL6 CXCL8
13
Show member pathways
12.22 MMP9 MMP3 MMP1 IL6 IL1B CXCL8
14 12.17 MMP9 MMP2 MMP1 IL6
15
Show member pathways
12.14 TIMP1 MMP3 MMP1
16
Show member pathways
12.12 IL6 IL1B CXCL8
17 12.11 IL6 IL1B CXCL8
18 12.1 IL6 CXCL8 CALML6
19 12.09 MMP9 MMP2 IL1B CALML6
20 12.01 MMP9 IL6 IL1B CXCL8
21
Show member pathways
11.99 MMP9 MMP3 MMP2 IL6 IL1B
22 11.98 MMP9 MMP3 IL6 IL1B
23 11.96 MMP9 MMP3 MMP2
24 11.95 IL6 IL1B CXCL8
25 11.95 PLAU IL6 IL1B CXCL8
26 11.92 MMP2 IL6 IL1B CXCL8
27 11.87 PLAU IL1B CXCL8
28 11.87 IL6 IL1B CXCL8
29 11.84 MMP3 MMP1 IL6 IL1B CXCL8
30
Show member pathways
11.84 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
31 11.79 IL6 IL1B CXCL8 CALML6
32 11.78 TIMP2 TIMP1 MMP9 MMP3 MMP2
33 11.77 MMP1 IL6 CXCL8
34 11.76 MMP9 MMP2 MMP1 CXCL8
35 11.75 IL6 IL1B CXCL8
36 11.75 MMP9 MMP2 CXCL8
37 11.74 MMP9 MMP3 IL6 IL1B
38 11.69 MMP9 MMP2 IL6 CXCL8
39 11.61 TIMP1 MMP9 MMP3 MMP2 MMP1 IL6
40 11.6 IL6 IL1B CXCL8
41
Show member pathways
11.6 MMP9 MMP3 MMP2 MMP1 IL6 IL1B
42 11.59 PLAU MMP2 IL6 CXCL8
43 11.55 MMP1 IL6 CXCL8
44 11.53 IL6 IL1B CXCL8
45 11.53 TIMP1 IL6 IL1B CXCL8
46 11.51 PLAU MMP9 MMP2 IL6
47 11.5 TIMP1 PLAU MMP9 MMP2 IL6 IL1B
48
Show member pathways
11.48 PLAU MMP9 MMP2
49 11.4 TIMP2 MMP9 MMP3 MMP1
50 11.33 PLAU MMP9 MMP2 MMP1 IL6 CXCL8

GO Terms for Conjunctivochalasis

Cellular components related to Conjunctivochalasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TIMP2 TIMP1 PLAU MMP9 MMP3 MMP2
2 extracellular region GO:0005576 9.65 TIMP2 TIMP1 PLAU MMP9 MMP3 MMP2
3 extracellular matrix GO:0031012 9.1 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1

Biological processes related to Conjunctivochalasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.89 PLAU MMP9 MMP3 MMP2 MMP1
2 negative regulation of cell proliferation GO:0008285 9.84 TIMP2 IL6 IL1B CXCL8
3 extracellular matrix organization GO:0030198 9.76 MMP9 MMP3 MMP2 MMP1
4 cellular protein metabolic process GO:0044267 9.73 TIMP1 MMP2 MMP1 IL6
5 embryo implantation GO:0007566 9.54 MMP9 MMP2 IL1B
6 positive regulation of glial cell proliferation GO:0060252 9.52 IL6 IL1B
7 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 IL1B
8 response to amyloid-beta GO:1904645 9.5 MMP9 MMP3 MMP2
9 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.48 TIMP2 TIMP1
10 collagen catabolic process GO:0030574 9.46 MMP9 MMP3 MMP2 MMP1
11 regulation of neuroinflammatory response GO:0150077 9.43 MMP9 MMP3 IL6
12 extracellular matrix disassembly GO:0022617 9.43 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
13 negative regulation of metallopeptidase activity GO:1905049 9.4 TIMP2 TIMP1
14 cytokine-mediated signaling pathway GO:0019221 9.23 TIMP1 MMP9 MMP3 MMP2 MMP1 IL6

Molecular functions related to Conjunctivochalasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.77 PLAU MMP9 MMP3 MMP2 MMP1
2 zinc ion binding GO:0008270 9.73 TIMP2 TIMP1 MMP9 MMP3 MMP2 MMP1
3 cytokine activity GO:0005125 9.62 TIMP1 IL6 IL1B CXCL8
4 endopeptidase activity GO:0004175 9.58 MMP9 MMP3 MMP1
5 metallopeptidase activity GO:0008237 9.46 MMP9 MMP3 MMP2 MMP1
6 metalloendopeptidase inhibitor activity GO:0008191 9.43 TIMP2 TIMP1
7 metalloendopeptidase activity GO:0004222 9.26 MMP9 MMP3 MMP2 MMP1
8 serine-type endopeptidase activity GO:0004252 9.02 PLAU MMP9 MMP3 MMP2 MMP1

Sources for Conjunctivochalasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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