MCID: CNN004
MIFTS: 33

Connective Tissue Cancer

Categories: Cancer diseases

Aliases & Classifications for Connective Tissue Cancer

MalaCards integrated aliases for Connective Tissue Cancer:

Name: Connective Tissue Cancer 12 15
Neoplasms, Connective Tissue 43 71
Neoplasm of Connective Tissues 12
Tumour of Connective Tissue 12
Connective Tissue Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:201
MeSH 43 D009372
UMLS 71 C0027656

Summaries for Connective Tissue Cancer

Disease Ontology : 12 A musculoskeletal system cancer that is located in connective tissue.

MalaCards based summary : Connective Tissue Cancer, also known as neoplasms, connective tissue, is related to pleural cancer and bone cancer. An important gene associated with Connective Tissue Cancer is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is MicroRNAs in cancer. The drugs Cranberry and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include connective tissue, bone and thyroid.

Related Diseases for Connective Tissue Cancer

Diseases related to Connective Tissue Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 pleural cancer 32.8 MIR29C MIR223 MIR193A MIR17 H2AC18
2 bone cancer 32.7 SERPINA3 MIR9-1 MIR31 MIR21 MIR199A1 MIR193A
3 kaposi sarcoma 11.1
4 chondrosarcoma 11.1
5 fibrosarcoma 11.1
6 spindle cell sarcoma 11.1
7 epithelioid sarcoma 11.1
8 skeletal muscle cancer 10.8 SERPINA3 MIR199A1 H2AC18 EWSR1
9 cervix small cell carcinoma 10.8 MIR199A1 MIR125B1 MIR100
10 parasitic helminthiasis infectious disease 10.8 SERPINA3 MIR21 H2AC18 CCR6
11 pre-malignant neoplasm 10.8 MIR193A MIR17 MIR142 H2AC18
12 cecal disease 10.8 SERPINA3 H2AC18 CCR6
13 in situ carcinoma 10.8 MIR193A MIR17 MIR142 H2AC18
14 tonsil cancer 10.8 SERPINA3 MIR199A1 H2AC18
15 cervix carcinoma 10.8 SERPINA3 MIR199A1 MIR142 H2AC18
16 ovary adenocarcinoma 10.8 SERPINA3 MIR29C MIR17 H2AC18
17 muscle cancer 10.8 SERPINA3 MIR9-1 MIR199A1 H2AC18 EWSR1
18 extrinsic cardiomyopathy 10.8 MIR223 MIR21 H2AC18 CCR6
19 bone resorption disease 10.8 MIR199A1 MIR142 MIR140 H2AC18 CCR6
20 bone remodeling disease 10.8 MIR199A1 MIR142 MIR140 H2AC18 CCR6
21 heart conduction disease 10.8 MIR21 MIR199A1 MIR142 MIR126 H2AC18
22 retinal vascular disease 10.8 MIR21 MIR199A1 MIR126 H2AC18
23 lipid storage disease 10.8 SERPINA3 MIR199A1 H2AC18 CCR6
24 substance abuse 10.8 SERPINA3 MIR199A1 H2AC18 CCR6
25 heart valve disease 10.8 SERPINA3 MIR21 MIR199A1 MIR126
26 laryngeal disease 10.8 MIR21 MIR17 MIR142 H2AC18 CCR6
27 testicular disease 10.8 SERPINA3 MIR199A1 KDM4C H2AC18 CCR6
28 aortic valve disease 2 10.8 SERPINA3 MIR21 MIR199A1 MIR17 MIR126
29 primary bacterial infectious disease 10.8 SERPINA3 MIR223 MIR21 H2AC18 CCR6
30 tongue disease 10.8 MIR21 MIR199A1 MIR17 CCR6
31 intrinsic cardiomyopathy 10.8 MIR21 MIR199A1 MIR142 MIR126 H2AC18
32 fetal alcohol spectrum disorder 10.8 MIR9-1 MIR140 KDM4C H2AC18
33 coccidiosis 10.8 SERPINA3 H2AC18 CCR6
34 synovium cancer 10.8 SERPINA3 EWSR1 CFAP47
35 thyroid gland papillary carcinoma 10.8 MIR9-1 MIR199A1 MIR17 MIR140
36 chromosomal deletion syndrome 10.8 MIR9-1 MIR17 MIR142 H2AC18
37 x-linked recessive disease 10.8 SERPINA3 MIR223 MIR142 H2AC18 CCR6
38 chondroblastoma 10.8 SERPINA3 KDM4C H2AC18
39 gallbladder disease 10.8 SERPINA3 MIR29C MIR199A1 MIR17 MIR142
40 idiopathic interstitial pneumonia 10.8 MIR21 MIR199A1 MIR142 CCR6
41 plasma protein metabolism disease 10.8 SERPINA3 MIR9-1 CCR6
42 skin melanoma 10.8 MIR29C MIR199A1 H2AC18 CCR6
43 collagen disease 10.8 SERPINA3 MIR223 MIR21 MIR142 H2AC18 CCR6
44 pleural disease 10.8 MIR29C MIR223 MIR125B1 H2AC18 CCR6
45 uveal disease 10.8 SERPINA3 MIR9-1 MIR199A1 MIR142 H2AC18 CCR6
46 rhabdoid cancer 10.8 KDM4C H2AC18 EWSR1
47 oropharynx cancer 10.8 SERPINA3 MIR9-1 H2AC18
48 rectum cancer 10.8 MIR31 MIR21 MIR193A MIR17
49 mycobacterium tuberculosis 1 10.8 SERPINA3 MIR223 MIR21 H2AC18 CCR6
50 muscle tissue disease 10.8 SERPINA3 MIR9-1 MIR199A1 MIR142 H2AC18 CCR6

Graphical network of the top 20 diseases related to Connective Tissue Cancer:



Diseases related to Connective Tissue Cancer

Symptoms & Phenotypes for Connective Tissue Cancer

Drugs & Therapeutics for Connective Tissue Cancer

Drugs for Connective Tissue Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cranberry Approved, Investigational Phase 3
2
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
3
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
4 Grape Approved Phase 3
5
Modafinil Approved, Investigational Phase 3 68693-11-8 4236
6
Camptothecin Experimental Phase 3 7689-03-4
7 Alkylating Agents Phase 3
8 Cytochrome P-450 CYP3A Inducers Phase 3
9 topoisomerase I inhibitors Phase 3
10 Central Nervous System Stimulants Phase 3
11 Immunologic Factors Phase 3
12 Vaccines Phase 3
13 Topoisomerase Inhibitors Phase 3
14 Mitogens Phase 2
15 Pharmaceutical Solutions Phase 2
16 Antibodies Phase 2
17 Immunoglobulins Phase 2
18
Somatostatin Approved, Investigational Early Phase 1 51110-01-1, 38916-34-6 53481605
19
Phenylalanine Approved, Investigational, Nutraceutical Early Phase 1 63-91-2 6140

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial Protocol for Therapeutic MRI-guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids in a 3T MRI Scanner Completed NCT01064960 Phase 3
2 A Multi-Center Phase III, Randomized, Open-Label Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Combination With Irinotecan and Temozolomide as a Second-Line Regimen for Ewing's Sarcoma Recruiting NCT03495921 Phase 3 Irinotecan;Temozolomide
3 BGJ398 for the Treatment of Tumor-Induced Osteomalacia Recruiting NCT03510455 Phase 2 BGJ398
4 A Phase 2 Open-Label Trial to Assess the Efficacy and Safety of KRN23 in Patients With Tumor-Induced Osteomalacia or Epidermal Nevus Syndrome Active, not recruiting NCT02722798 Phase 2 KRN23
5 A Phase 2 Open-Label Trial to Assess the Efficacy and Safety of KRN23, an Antibody to FGF23, in Subjects With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS)-Associated Osteomalacia Active, not recruiting NCT02304367 Phase 2
6 Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Unknown status NCT02331966
7 68Ga-DOTATATE PET/CT for Detection and Evaluation of the Causative Tumor of Oncogenic Osteomalacia Unknown status NCT01524016 Early Phase 1 68Ga-DOTATATE

Search NIH Clinical Center for Connective Tissue Cancer

Cochrane evidence based reviews: neoplasms, connective tissue

Genetic Tests for Connective Tissue Cancer

Anatomical Context for Connective Tissue Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Connective Tissue Cancer:

19
Connective Tissue

MalaCards organs/tissues related to Connective Tissue Cancer:

40
Bone, Thyroid, Breast, B Cells, Heart, Skin, Cervix

Publications for Connective Tissue Cancer

Articles related to Connective Tissue Cancer:

(show all 19)
# Title Authors PMID Year
1
Factors influencing people's ability to maintain their activity levels during treatment for soft tissue sarcoma - A qualitative study. 61
30216104 2018
2
Model of vascular desmoplastic multispecies tumor growth. 61
28529153 2017
3
Malignant Peripheral Nerve Sheath Tumor Is a Challenging Diagnosis: A Systematic Pathology Review, Immunohistochemistry, and Molecular Analysis in 160 Patients From the French Sarcoma Group Database. 61
27158754 2016
4
Are peripheral purely undifferentiated pleomorphic sarcomas with MDM2 amplification dedifferentiated liposarcomas? 61
24525499 2014
5
Minimal excess risk of cancer and reduced risk of death from cancer in Australian Department of Veterans' Affairs clients: a record linkage study. 61
24494942 2014
6
Adherence to treatment guidelines for primary sarcomas affects patient survival: a side study of the European CONnective TIssue CAncer NETwork (CONTICANET). 61
23446092 2013
7
Clinicians' adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions. 61
22455759 2012
8
Pulmonary tuberculosis causing lipoid pneumonia. 61
18018534 2007
9
Family history of breast cancer and young age at diagnosis of breast cancer increase risk of second primary malignancies in women: a population-based cohort study. 61
17024122 2006
10
Long-term effects of connective tissue cancer treatment. 61
15346055 2004
11
An EM algorithm for mapping binary disease loci: application to fibrosarcoma in a four-way cross mouse family. 61
14768897 2003
12
Incidence of cancer among patients with knee implants in Sweden, 1980-1994. 61
12115397 2002
13
Parental cancer as a risk factor for bone cancer: a nation-wide study from Sweden. 61
11809347 2002
14
Nationwide study of cancer risk among hip replacement patients in Sweden. 61
11562392 2001
15
[Hereditary prolidase deficiency. Contribution to differential therapy refractory leg ulcer diagnosis]. 61
11116849 2000
16
A case-control study of prosthetic implants and selected chronic diseases. 61
8978883 1996
17
Cancer risk after hip replacement with metal implants: a population-based cohort study in Sweden. 61
7666459 1995
18
Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Connecticut, 1935-82. 61
4088297 1985
19
Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Denmark, 1943-80. 61
4088310 1985

Variations for Connective Tissue Cancer

Expression for Connective Tissue Cancer

Search GEO for disease gene expression data for Connective Tissue Cancer.

Pathways for Connective Tissue Cancer

Pathways related to Connective Tissue Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 MIR9-1 MIR31 MIR29C MIR223 MIR21 MIR199A1

GO Terms for Connective Tissue Cancer

Cellular components related to Connective Tissue Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 SERPINA3 MIR31 MIR29C MIR223 MIR21 MIR199A1

Biological processes related to Connective Tissue Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.67 MIR126 MIR199A1 MIR21 MIR31
2 negative regulation of angiogenesis GO:0016525 9.62 MIR125B1 MIR193A MIR21 MIR29C
3 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.61 MIR193A MIR21 MIR29C
4 negative regulation of toll-like receptor signaling pathway GO:0034122 9.52 MIR17 IRF4
5 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.51 MIR199A1 MIR17
6 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.49 MIR199A1 MIR17
7 positive regulation of metalloendopeptidase activity GO:1904685 9.48 MIR17 MIR21
8 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.46 MIR125B1 MIR21
9 negative regulation of vascular endothelial cell proliferation GO:1905563 9.43 MIR126 MIR193A MIR29C
10 miRNA mediated inhibition of translation GO:0035278 9.43 MIR100 MIR125B1 MIR17 MIR21 MIR31 MIR9-1
11 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.4 MIR17 MIR21
12 gene silencing by miRNA GO:0035195 9.36 MIR125B1 MIR126 MIR140 MIR17 MIR193A MIR199A1
13 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.33 MIR140 MIR21 MIR223

Molecular functions related to Connective Tissue Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR9-1 MIR31 MIR29C MIR223 MIR21 MIR199A1

Sources for Connective Tissue Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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