MCID: CNS002
MIFTS: 39

Constrictive Pericarditis

Categories: Cardiovascular diseases

Aliases & Classifications for Constrictive Pericarditis

MalaCards integrated aliases for Constrictive Pericarditis:

Name: Constrictive Pericarditis 12 15 17
Pericarditis, Constrictive 44 70
Pericarditis Constrictive 54

Classifications:



External Ids:

Disease Ontology 12 DOID:11481
ICD9CM 34 423.2
MeSH 44 D010494
NCIt 50 C78246
SNOMED-CT 67 155340008
UMLS 70 C0031048

Summaries for Constrictive Pericarditis

MalaCards based summary : Constrictive Pericarditis, also known as pericarditis, constrictive, is related to hemopericardium and pericarditis. An important gene associated with Constrictive Pericarditis is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related phenotypes are cardiovascular system and muscle

Wikipedia : 73 Constrictive pericarditis is a medical condition characterized by a thickened, fibrotic pericardium,... more...

Related Diseases for Constrictive Pericarditis

Diseases related to Constrictive Pericarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 619)
# Related Disease Score Top Affiliating Genes
1 hemopericardium 31.8 TNNI3 CRP
2 pericarditis 31.5 TNNI3 NPPB IFNG CRP ALB ADA
3 restrictive cardiomyopathy 31.2 TTN TNNI3 NPPB ACE
4 mediastinitis 30.9 CRP ALB
5 atrial standstill 1 30.9 TTN TNNI3 NPPB ACE
6 pleurisy 30.6 IFNG CRP ADA
7 pulmonary tuberculosis 30.5 IFNG ALB ADA
8 mitral valve stenosis 30.5 REN NPPB CRP ACE
9 pericardial effusion 30.4 TNNI3 REN NPPB CRP ALB ADA
10 pleural empyema 30.4 CRP ALB ADA
11 sarcoidosis 1 30.3 IFNG CRP ADA ACE
12 bilirubin metabolic disorder 30.3 SERPINA1 CRP ALB
13 cat-scratch disease 30.3 CRP ACE
14 amyloidosis 30.3 TTN TNNI3 NPPB CRP ALB
15 angina pectoris 30.3 TNNI3 NPPB CRP ACE
16 esophageal varix 30.3 SERPINA1 ALB
17 brucellosis 30.2 IFNG CRP ADA
18 cardiac tamponade 30.2 TNNI3 REN NPPB CRP ALB ADA
19 nocardiosis 30.2 IFNG CRP
20 atrial heart septal defect 30.1 TTN TNNI3 NPPB CRP ALB ACE
21 atrial fibrillation 30.1 TTN NPPB CRP ACE
22 juvenile rheumatoid arthritis 30.1 IFNG CRP ALB
23 endocarditis 30.1 TNNI3 IFNG CRP ALB
24 miliary tuberculosis 30.1 IFNG CRP ALB ADA
25 inferior myocardial infarction 30.1 TNNI3 NPPB ACE
26 myocarditis 30.1 TTN TNNI3 NPPB IFNG ACE
27 right bundle branch block 30.1 TNNI3 NPPB ACE
28 tricuspid valve insufficiency 30.1 TNNI3 REN NPPB CRP ALB ACE
29 pulmonary valve insufficiency 30.1 REN NPPB CRP ACE
30 connective tissue disease 30.1 IFNG CRP ALB ACE
31 silent myocardial infarction 30.1 TNNI3 CRP ACE
32 diastolic heart failure 30.0 TTN TNNI3 REN NPPB ACE
33 pulmonary hypertension 30.0 REN NPPB CRP ALB ACE
34 uremia 30.0 REN CRP ALB ACE
35 purpura 30.0 IFNG CRP ACE
36 end stage renal disease 30.0 REN NPPB CRP ALB ACE
37 severe acute respiratory syndrome 30.0 IFNG CRP ACE
38 exanthem 29.9 IFNG CRP ALB ACE
39 atrioventricular block 29.9 TTN TNNI3 NPPB ACE
40 hypokalemia 29.9 REN ALB ACE
41 arteries, anomalies of 29.8 TNNI3 REN CRP ALB ACE
42 pulmonary disease, chronic obstructive 29.8 SERPINA1 NPPB CRP ALB ACE
43 disease by infectious agent 29.8 SERPINA1 IFNG CRP ALB
44 pericardial tuberculosis 29.8 IFNG CRP CALB2 ADA
45 acute myocardial infarction 29.8 TNNI3 NPPB CRP ACE
46 interstitial lung disease 29.8 IFNG CRP ALB
47 tetralogy of fallot 29.8 TNNI3 REN NPPB CRP ACE
48 rheumatic fever 29.8 NPPB IFNG ALB ACE
49 systemic scleroderma 29.8 IFNG CRP ADA ACE
50 abdominal tuberculosis 29.8 IFNG CRP ALB ADA

Comorbidity relations with Constrictive Pericarditis via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome
Mitral Valve Disease

Graphical network of the top 20 diseases related to Constrictive Pericarditis:



Diseases related to Constrictive Pericarditis

Symptoms & Phenotypes for Constrictive Pericarditis

MGI Mouse Phenotypes related to Constrictive Pericarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 ACE ADA ALB CRP IFNG REN
2 muscle MP:0005369 9.5 ADA ALB IFNG REN TNNI3 TRIM37
3 normal MP:0002873 9.17 ADA ALB CALB2 IFNG REN SERPINA1

Drugs & Therapeutics for Constrictive Pericarditis

Drugs for Constrictive Pericarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Septal Shift for the Diagnosis of COnstrictive Pericarditis: The Impact of Inspiratory Effort Quantification on Deep Breathing Manoeuvres (SCOPED) Unknown status NCT02685371
2 Characterization of the Liver Parenchyma Using Parametric T1 and T2 Magnetic Resonance Relaxometry Completed NCT04623528
3 Constrictive Pericarditis in the Adult Congenital Cardiac Population Terminated NCT00268086
4 Pressure-Volume Analysis of Constrictive Pericarditis Withdrawn NCT02027350

Search NIH Clinical Center for Constrictive Pericarditis

Cochrane evidence based reviews: pericarditis, constrictive

Genetic Tests for Constrictive Pericarditis

Anatomical Context for Constrictive Pericarditis

MalaCards organs/tissues related to Constrictive Pericarditis:

40
Heart, Kidney, Liver, Lung, Thymus, Skin, Myeloid

Publications for Constrictive Pericarditis

Articles related to Constrictive Pericarditis:

(show top 50) (show all 3105)
# Title Authors PMID Year
1
Two cases of restrictive cardiomyopathy in children. 54 61
20035098 2009
2
Utility of BNP in differentiating constrictive pericarditis from restrictive cardiomyopathy in patients with renal insufficiency. 54 61
17923360 2007
3
B-type natriuretic peptide level in a patient with constrictive pericarditis. 54 61
17086538 2006
4
Brain natriuretic peptide levels in constrictive pericarditis and restrictive cardiomyopathy. 61 54
16580543 2006
5
The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy. 54 61
15936624 2005
6
The diagnostic and prognostic value of adenosine deaminase in tuberculous pericarditis. 61 54
8665976 1995
7
Pericardial Involvement in Cancer. 61
33460602 2021
8
A novel model of constrictive pericarditis associated with myocardial fibrosis in rats. 61
33349990 2021
9
A rare case of primary angiosarcoma of the anterior mediastinum. 61
33222090 2021
10
Outcomes of Tricuspid Valve Operation at the Time of Pericardiectomy for Constrictive Pericarditis. 61
32896543 2021
11
Constrictive Pericarditis after Open Heart Surgery: A 20-Year Case Controlled Study. 61
33421450 2021
12
Clinical features and prognosis of surgically proven constrictive pericarditis after orthotopic heart transplantation. 61
33546972 2021
13
Egg-shell calcification in Pick's disease (chronic constrictive pericarditis). 61
33552337 2021
14
Anesthetic consideration for airway management in patient undergoing tracheal resection and reconstruction for severe postintubation tracheal stenosis: a case report. 61
33593198 2021
15
Delayed-onset constrictive pericarditis associated with trauma. 61
33727294 2021
16
Dilated right ventricular outflow tract in a young woman due to localized constrictive pericarditis: cardiac CT and MRI findings. 61
33408800 2021
17
MELD and MELD XI Scores as Predictors of Mortality After Pericardiectomy for Constrictive Pericarditis. 61
33673914 2021
18
Ventricular Systolic Discordance Post-Premature Ventricular Complex in Constrictive Pericarditis: A Novel Description. 61
33663233 2021
19
Tuberculosis and the Heart. 61
33733808 2021
20
Calcified constrictive pericarditis resulting in tamponade in a patient with systemic lupus erythematosus. 61
33206224 2021
21
Use of Impella RP for acute right ventricular failure post pericardiectomy. 61
33627297 2021
22
MiR-146a mediates TLR-4 signaling pathway to affect myocardial fibrosis in rat constrictive pericarditis model. 61
33717566 2021
23
An unusual presentation of dyspnea following septal ablation for obstructive hypertrophic cardiomyopathy. 61
33345409 2021
24
Effusive-Constrictive Pericarditis due to Immune Reconstitution Inflammatory Syndrome following Tuberculous Pericarditis. 61
33644517 2021
25
Localized constrictive pericarditis resulting in biventricular aneurysm-like apical outpouching. 61
33583821 2021
26
Prognostic importance of mitral e' velocity in constrictive pericarditis. 61
32514577 2021
27
Effusive-constrictive pericarditis secondary to pneumopericardium associated with gastropericardial fistula. 61
33300689 2021
28
Interval imaging to guide treatment in constrictive pericarditis. 61
33568431 2021
29
Meta-Analysis of Population Characteristics and Outcomes of Patients Undergoing Pericardiectomy for Constrictive Pericarditis. 61
33539860 2021
30
Pericardiectomy for Constrictive Pericarditis: Analysis of Outcomes. 61
33722460 2021
31
Dual energy imaging in cardiothoracic pathologies: A primer for radiologists and clinicians. 61
33532519 2021
32
Squamous Cell Carcinoma of Thymus Presenting as Constrictive Pericarditis Diagnosed With 18F-FDG PET/CT. 61
32701799 2021
33
Rheumatic pericarditis: a rare cause of constrictive pericarditis. 61
33495174 2021
34
Diagnosis and etiological identification in severe constrictive pericarditis in a 14-year-old girl: a case report. 61
33633955 2021
35
Improvement in left ventricular mechanics following medical treatment of constrictive pericarditis. 61
33408090 2021
36
Refractory constrictive pericarditis caused by an immune checkpoint inhibitor properly managed with infliximab: a case report. 61
33644656 2021
37
Effusive-constrictive pericarditis in the spectrum of pericardial compressive syndromes. 61
33452122 2021
38
Effusive constrictive pericarditis in systemic sclerosis. 61
32910757 2021
39
Clinical Presentation and Outcomes of Acute Pericarditis in a Large Urban Hospital in the United States of America. 61
32717264 2020
40
Total Pericardiectomy via Modified Left Anterolateral Thoracotomy without Cardiopulmonary Bypass. 61
33310149 2020
41
An update on the pathophysiology of acute and recurrent pericarditis. 61
33337127 2020
42
Annular Indentation of the Ventricles in a Stillborn: A Case Report and Literature Review. 61
33305650 2020
43
[Pericarditis in contemporary therapeutic clinic: nosological spectrum, approaches to diagnosis and treatment]. 61
33720567 2020
44
Exercise syncope: An unusual presentation of a constrictive pericarditis in a young patient. 61
33388143 2020
45
Our experience of total pericardiectomy for constrictive pericarditis: a comprehensive analysis over a period of 5 years. 61
33552183 2020
46
Chronic calcific effusive constrictive pericarditis: a rare entity within the spectrum of pericardial diseases-a case report. 61
33629021 2020
47
Right ventricular dysfunction due to effusive-constrictive pericarditis. 61
32939847 2020
48
Chryseobacterium bacteraemia in a patient with heart failure: case report and literature review. 61
33447698 2020
49
Postcardiotomy effusive-constrictive pericarditis in a 65-year-old man: Noteworthy echocardiographic signs. 61
33179802 2020
50
Constrictive Pericarditis Associated with Coronavirus Disease 2019 (COVID-19): A Case Report. 61
33297919 2020

Variations for Constrictive Pericarditis

Expression for Constrictive Pericarditis

Search GEO for disease gene expression data for Constrictive Pericarditis.

Pathways for Constrictive Pericarditis

Pathways related to Constrictive Pericarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 TNNI3 SERPINA1 ALB

GO Terms for Constrictive Pericarditis

Cellular components related to Constrictive Pericarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TTN SERPINA1 REN NPPB IFNG CRP
2 extracellular space GO:0005615 9.23 SERPINA1 REN NPPB IFNG CRP ALB

Biological processes related to Constrictive Pericarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.54 TTN SERPINA1 ALB
2 regulation of blood vessel diameter GO:0097746 9.4 NPPB ACE
3 heart contraction GO:0060047 9.32 TNNI3 ACE
4 striated muscle contraction GO:0006941 9.26 TTN TNNI3
5 amyloid-beta metabolic process GO:0050435 9.16 REN ACE
6 angiotensin maturation GO:0002003 8.96 REN ACE
7 regulation of blood pressure GO:0008217 8.8 REN NPPB ACE

Sources for Constrictive Pericarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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