MCID: CNT001
MIFTS: 34

Contagious Pustular Dermatitis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Contagious Pustular Dermatitis

MalaCards integrated aliases for Contagious Pustular Dermatitis:

Name: Contagious Pustular Dermatitis 12 15
Ecthyma, Contagious 12 44 73
Ecthyma Contagiosum 12
Thistle Disease 12
Scabby Mouth 12
Sheep Pox 12
Orf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8771
ICD10 33 B08.02
ICD9CM 35 051.2
MeSH 44 D004474
UMLS 73 C0013570

Summaries for Contagious Pustular Dermatitis

Disease Ontology : 12 A viral infectious disease that results in infection located in skin, has material basis in Orf virus, which is transmitted by contact with infected or recently vaccinated animals, or transmitted by fomites carrying the virus. The infection has symptom lesions on the finger, hand, arm, face, and penis.

MalaCards based summary : Contagious Pustular Dermatitis, also known as ecthyma, contagious, is related to milker's nodule and dermatitis, and has symptoms including lesions on the finger An important gene associated with Contagious Pustular Dermatitis is LAGE3 (L Antigen Family Member 3). The drugs Dopamine and Guanfacine have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Orf is an exanthemous disease caused by a parapox virus and occurring primarily in sheep and goats. It... more...

Related Diseases for Contagious Pustular Dermatitis

Diseases related to Contagious Pustular Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 milker's nodule 11.3
2 dermatitis 10.8
3 ecthyma 10.2
4 skin disease 10.1
5 vaccinia 10.0

Graphical network of the top 20 diseases related to Contagious Pustular Dermatitis:



Diseases related to Contagious Pustular Dermatitis

Symptoms & Phenotypes for Contagious Pustular Dermatitis

Symptoms:

12
  • lesions on the finger

GenomeRNAi Phenotypes related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.96 FOXK1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.96 PRODH
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.96 ELAVL2 FOXK1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.96 PRODH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.96 FOXK1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.96 FOXK1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.96 FOXK1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.96 FOXK1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.96 PRODH
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.96 AKR7A2 ELAVL2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.96 CYC1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.96 AKR7A2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.96 CYC1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.96 PRODH
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.96 CYC1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.96 PRODH AKR7A2 FOXK1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.96 CYC1 PRODH
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.96 PRODH
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.96 CYC1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.96 CYC1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.96 CYC1 AKR7A2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.96 PRODH

Drugs & Therapeutics for Contagious Pustular Dermatitis

Drugs for Contagious Pustular Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
3
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
4
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
5 Adrenergic Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 Antihypertensive Agents Phase 4
8 adderall Phase 4
9 Central Nervous System Stimulants Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic alpha-2 Receptor Agonists Phase 4
12 Adrenergic alpha-Agonists Phase 4
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Dopamine Agents Phase 4
15 Dopamine Uptake Inhibitors Phase 4
16 Peripheral Nervous System Agents Phase 4,Phase 1
17 Atomoxetine Hydrochloride Phase 4
18 Autonomic Agents Phase 4
19
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
20
Vancomycin Approved Phase 3 1404-90-6 441141 14969
21
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
22
Iron Approved Phase 2, Phase 3 7439-89-6 23925
23
Camptothecin Experimental Phase 3 7689-03-4
24 topoisomerase I inhibitors Phase 3
25 Topoisomerase Inhibitors Phase 3
26 Dermatologic Agents Phase 3,Phase 2
27 Emollients Phase 3
28 Anti-Infective Agents Phase 3,Phase 2
29 Antineoplastic Agents, Phytogenic Phase 3
30 methicillin Phase 3
31 Anti-Bacterial Agents Phase 3
32 Chelating Agents Phase 2, Phase 3
33 Iron Chelating Agents Phase 2, Phase 3
34
Ethanol Approved Phase 2 64-17-5 702
35 Titanium dioxide Approved Phase 2 13463-67-7
36 Central Nervous System Depressants Phase 2,Phase 1
37 Sunscreening Agents Phase 2
38 Pharmaceutical Solutions Phase 2
39 Photosensitizing Agents Phase 2
40 Anti-Infective Agents, Local Phase 2
41 Protective Agents Phase 2
42 Radiation-Protective Agents Phase 2
43
Oxycodone Approved, Illicit, Investigational Phase 1 76-42-6 5284603
44
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
45
Bupropion Approved Phase 1 34841-39-9, 34911-55-2 444
46
Caffeine Approved, Nutraceutical Phase 1 58-08-2 2519
47 Analgesics Phase 1
48 Narcotics Phase 1
49 Analgesics, Opioid Phase 1
50
Propylthiouracil Approved, Investigational 51-52-5 657298

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Interventions for Children With Attention and Reading Disorders Completed NCT01133847 Phase 4 Methylphenidate;Mixed Salt Amphetamine;Atomoxetine;Guanfacine
2 Long-term Efficacy and Safety of V0034 CR 01B Cream in Patients With Moderate-to-severe Uremic Xerosis Completed NCT01084148 Phase 3 V0034CR01B;V0034CR01B vehicle
3 Efficacy, Local Tolerance and Patient Acceptability of a Moisturizing Emollient in Patients With Uremic Xerosis Completed NCT01084720 Phase 3 V0034 CR
4 Irinotecan Versus Only Best Supportive Care for Gastric Cancer Completed NCT00144378 Phase 3 Irinotecan
5 A Study of AeroVanc for the Treatment of MRSA Infection in CF Patients Recruiting NCT03181932 Phase 3 Vancomycin inhalation powder;Placebo inhalation powder
6 Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis Not yet recruiting NCT03293069 Phase 2, Phase 3 Deferiprone;Placebo Oral Tablet
7 Evaluation of the Protection Activity of Microfine Titanium Dioxide (Ti02), Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With Idiopathic Solar Urticaria (SU) Completed NCT00483496 Phase 2 Titanium dioxide (Ti02) microfine 12.15% alone (formula RV3131A-MV1209);Ti02 pigmentary 3% alone (formula RV3131A-MV1211);bisoctrizole 10% alone (formula RV3131A-MV1237);Ti02 microfine 12.15% + Ti02 pigmentary 3% (formula RV3131A-MV1213);Ti02 microfine 12.15% + bisoctrizole 10% (formula RV3131A-MV1329);Ti02 pigmentary 3% + bisoctrizole 10% (formula RV3131A-MV1212);Ti02 microfine 12.15% + Ti02 pigmentary 3% + bisoctrizole 10% [V0096 CR (formula RV3131A-MV1166)];V0096 CR vehicle (formula RV3131A-MV1197)
8 Systemic and Local Diffusion of Ethanol After Administration of Ethanol 96% Formulated in a Gel and Ethanol 98% Solution by the Percutaneous Route, in Patients With Congenital Venous Malformations:Pharmacokinetic, Pharmacodynamic and Clinical Study. Completed NCT00462462 Phase 2 Ethanol 96% Gel;Ethanol 98% Solution
9 Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR-ORF15 Mutations Recruiting NCT03316560 Phase 1, Phase 2
10 Pharmacokinetics and Safety of ORF Tablets in Pediatric Patients Completed NCT01160614 Phase 1 Oxycodone hydrochloride controlled-release (ORF) tablets
11 Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis Recruiting NCT03140527 Phase 1 PTI-801;Placebo;PTI-808;Placebo
12 The Epidemiology of Hepatitis E Virus Infection in Israel and Potential Risk Factors Unknown status NCT02419625 Not Applicable
13 Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism Unknown status NCT02812888 thionamide treatment for 3 months
14 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
15 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
16 Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity Unknown status NCT02148562
17 Protocol TARC-ABPA Completed NCT01710930 Not Applicable
18 Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation Recruiting NCT01925196
19 Clinical Evaluation of Patients With X-linked Retinitis Pigmentosa (XLRP) Recruiting NCT03314207
20 Predict to Prevent Frontotemporal Lobar Degeneration (FDT) and Amyotrophic Lateral Sclerosis (ALS) Recruiting NCT02590276 Not Applicable
21 Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Recruiting NCT02372773
22 Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders Recruiting NCT01459302
23 Study of Predictive Factors of Progression of Lateral Amyotrophic Sclerosis Recruiting NCT02360891
24 The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study Recruiting NCT00317616
25 Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS Active, not recruiting NCT02686268
26 Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS Not yet recruiting NCT03573466 Not Applicable

Search NIH Clinical Center for Contagious Pustular Dermatitis

Cochrane evidence based reviews: ecthyma, contagious

Genetic Tests for Contagious Pustular Dermatitis

Anatomical Context for Contagious Pustular Dermatitis

The Foundational Model of Anatomy Ontology organs/tissues related to Contagious Pustular Dermatitis:

19
Skin

MalaCards organs/tissues related to Contagious Pustular Dermatitis:

41
Skin, Eye, Liver, Testes

Publications for Contagious Pustular Dermatitis

Articles related to Contagious Pustular Dermatitis:

(show all 39)
# Title Authors Year
1
Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis. ( 29778194 )
2018
2
Isolation and molecular characterization of contagious pustular dermatitis virus from Rajasthan, India. ( 25674607 )
2014
3
Molecular and virological studies on contagious pustular dermatitis isolates from Egyptian sheep and goats. ( 20304450 )
2010
4
Orf: contagious pustular dermatitis. ( 20666089 )
2010
5
Orf (contagious pustular dermatitis) in farmworkers: prevalence and risk factors in three areas of England. ( 10452390 )
1999
6
Western blot analysis of virus-specific antibody responses for capripox and contagious pustular dermatitis viral infections in sheep. ( 7925674 )
1994
7
Contagious pustular dermatitis (orf) infection in sheep and goats in Saudi Arabia. ( 1909477 )
1991
8
Molecular analysis of contagious pustular dermatitis virus: a simplified method for viral DNA extraction from scab material. ( 1816256 )
1991
9
Detection of contagious pustular dermatitis virus of goats in a severe outbreak. ( 2588444 )
1989
10
Orf: contagious pustular dermatitis. ( 3179870 )
1988
11
Contagious pustular dermatitis (orf) of sheep affecting the ear following ear tagging. ( 3606509 )
1987
12
Human orf (ecthyma contagious) a report of two cases from Saudi Arabia. ( 21164240 )
1986
13
Contagious pustular dermatitis of sheep--possible confusion with vesicular diseases. ( 4004656 )
1985
14
Antigenic relationships among sheep pox, goat pox and contagious pustular dermatitis viruses. ( 6151351 )
1984
15
Prevalence of contagious pustular dermatitis (orf) in six million lambs at slaughter: a three-year study. ( 16030998 )
1983
16
Cross-neutralization tests on sheep pox, goat pox and contagious pustular dermatitis viruses. ( 90458 )
1979
17
Contagious pustular dermatitis of sheep in a veterinary student. ( 584593 )
1977
18
Cytopathogenicity of contagious pustular dermatitis virus in primary cell culture with special reference to the formation of intracytoplasmic inclusions. ( 4675558 )
1972
19
The vaccination of young lambs against contagious pustular dermatitis. ( 5555757 )
1971
20
Propagation of contagious pustular dermatitis virus in HeLa cell cultures. ( 5169601 )
1971
21
An outbreak of contagious pustular dermatitis associated with Dermatophilus congolensis infection. ( 5274960 )
1970
22
Possible &amp;quot;orf&amp;quot; (contagious pustular dermatitis, contagious ecthyma of sheep) infection in the dog. ( 5494712 )
1970
23
A case of orf (ecthyma contagiosum; contagious pustular dermatitis) contracted by a human from a wild Alaskan mountain goat. ( 4297665 )
1968
24
Growth of contagious pustular dermatitis virus in human tissue cultures. ( 14467780 )
1961
25
Studies with a strain of contagious pustular dermatitis virus in tissue culture. ( 14433531 )
1959
26
The immunological relations of the contagious pustular dermatitis virus to the mammalian pox group. ( 13596274 )
1958
27
Contagious pustular dermatitis. IV. Immunological reactions. ( 13502481 )
1958
28
Human infections with the virus of ovine contagious pustular dermatitis (scabby mouth). ( 13430966 )
1957
29
Contagious pustular dermatitis. II. Pathological histology. ( 13449179 )
1957
30
Contagious pustular dermatitis. III. Experimental infection. ( 13481166 )
1957
31
Contagious pustular dermatitis virus. I. Studies on morphology. ( 13416415 )
1957
32
Orf: contagious pustular dermatitis of sheep. ( 13361058 )
1956
33
Complement-fixation tests in the diagnosis of contagious pustular dermatitis infection in man. ( 14898387 )
1951
34
Human infection with the virus of contagious pustular dermatitis. ( 14814843 )
1951
35
The immunological relationship between a new virus, proliferative dermatitis of the legs (strawberry foot rot) of sheep, and the viruses of vaccinia and contagious pustular dermatitis. ( 18099893 )
1948
36
A case of orf; contagious pustular dermatitis; identification of the virus. ( 18123062 )
1948
37
The immunological relationships of strains of contagious pustular dermatitis virus. ( 20293732 )
1947
38
The relationship between the virus of contagious pustular dermatitis and a virus isolated from sheep papillomatosis by Selbie. ( 20293733 )
1947
39
Infection of man by the virus of contagious pustular dermatitis of sheep. ( 20279048 )
1946

Variations for Contagious Pustular Dermatitis

Expression for Contagious Pustular Dermatitis

Search GEO for disease gene expression data for Contagious Pustular Dermatitis.

Pathways for Contagious Pustular Dermatitis

GO Terms for Contagious Pustular Dermatitis

Biological processes related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 8.8 AKR7A2 CYC1 PRODH

Molecular functions related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 8.62 AKR7A2 CYC1

Sources for Contagious Pustular Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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