MCID: CNV003
MIFTS: 29

Conventional Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Conventional Fibrosarcoma

MalaCards integrated aliases for Conventional Fibrosarcoma:

Name: Conventional Fibrosarcoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3517
NCIt 51 C9429
UMLS 74 C1333156

Summaries for Conventional Fibrosarcoma

MalaCards based summary : Conventional Fibrosarcoma is related to pleomorphic liposarcoma and retroperitoneal fibrosis. An important gene associated with Conventional Fibrosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include lung, skin and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Conventional Fibrosarcoma

Diseases related to Conventional Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 pleomorphic liposarcoma 10.4 MDM2 PDGFRA
2 retroperitoneal fibrosis 10.4 MDM2 PTPRC
3 reticular perineurioma 10.4 KIT PDGFRA
4 sm-ahnmd 10.3 KIT PDGFRA
5 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 PTPRC
6 gamma heavy chain disease 10.3 NRAS PTPRC
7 desmoid tumor 10.3 KIT PDGFRA
8 hypereosinophilic syndrome, idiopathic 10.3 KIT PDGFRA
9 lung adenoid cystic carcinoma 10.3 KIT PDGFRA
10 pulmonary vein stenosis 10.3 KIT PDGFRA
11 kidney rhabdoid cancer 10.3 ENO2 PTPRC
12 malignant spindle cell melanoma 10.3 KIT NRAS
13 acral lentiginous melanoma 10.3 KIT NRAS
14 nodular ganglioneuroblastoma 10.3 ENO2 MDM2
15 meningeal melanomatosis 10.3 ENO2 NRAS
16 carney triad 10.3 KIT PDGFRA
17 chronic eosinophilic leukemia 10.3 KIT PDGFRA
18 cutaneous ganglioneuroma 10.3 ENO2 KIT
19 gastric small cell carcinoma 10.3 ENO2 PTPRC
20 connective tissue benign neoplasm 10.3 ENO2 MDM2
21 undifferentiated pleomorphic sarcoma 10.3 KIT PDGFRA
22 extraskeletal ewing sarcoma 10.3 ENO2 PTPRC
23 rete testis adenocarcinoma 10.3 ENO2 KIT
24 vulvar melanoma 10.3 KIT NRAS
25 prostate small cell carcinoma 10.3 ENO2 KIT
26 melanomatosis 10.3 CD68 NRAS
27 neurofibromatosis, type i 10.3 KIT PDGFRA
28 congenital mesoblastic nephroma 10.3 KIT NRAS
29 nodular tenosynovitis 10.3 CD68 PTPRC
30 skin granular cell tumor 10.2 CD68 ENO2
31 granular cell tumor 10.2 CD68 ENO2
32 malignant giant cell tumor of soft parts 10.2 CD68 PTPRC
33 mucosal melanoma 10.2 KIT NRAS
34 brain sarcoma 10.2 CD68 PTPRC
35 malignant fibrous histiocytoma of bone 10.2 CALD1 MDM2
36 rete testis neoplasm 10.2 ENO2 KIT
37 axillary lipoma 10.2 CD68 KIT
38 malignant skin fibrous histiocytoma 10.2 KIT NRAS
39 embryonal sarcoma 10.2 KIT MDM2
40 bone ewing's sarcoma 10.2 ENO2 PTPRC
41 fox-fordyce disease 10.2 CD68 KIT
42 trigeminal nerve neoplasm 10.2 CD68 PTPRC
43 cloacogenic carcinoma 10.2 ENO2 PTPRC
44 neurilemmoma of the fifth cranial nerve 10.2 CD68 PTPRC
45 core binding factor acute myeloid leukemia 10.2 KIT NRAS
46 sclerosing liposarcoma 10.2 CD34 MDM2
47 photokeratitis 10.2 CD68 PTPRC
48 myxosarcoma 10.2 CD68 MDM2
49 liver inflammatory pseudotumor 10.2 CD34 PTPRC
50 fibrosarcoma of bone 10.2 KIT MDM2 PDGFRA

Graphical network of the top 20 diseases related to Conventional Fibrosarcoma:



Diseases related to Conventional Fibrosarcoma

Symptoms & Phenotypes for Conventional Fibrosarcoma

GenomeRNAi Phenotypes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.5 TNFRSF8
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.5 PDGFRA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.5 TNFRSF8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.5 KIT
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.5 PDGFRA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.5 KIT PDGFRA TNFRSF8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.5 TNFRSF8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.5 PDGFRA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.5 TNFRSF8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.5 TNFRSF8
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.5 KIT
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.5 PDGFRA
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.5 PDGFRA

MGI Mouse Phenotypes related to Conventional Fibrosarcoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 CD34 CD68 FN1 KIT MDM2 NRAS
2 cellular MP:0005384 10.1 CD34 ENO2 FN1 KIT MDM2 NRAS
3 immune system MP:0005387 10.09 CD34 CD68 FN1 KIT MDM2 NRAS
4 craniofacial MP:0005382 9.95 ENO2 FN1 KIT MDM2 NRAS PDGFRA
5 integument MP:0010771 9.88 CD34 FN1 KIT MDM2 NRAS PDGFRA
6 neoplasm MP:0002006 9.87 CD34 FN1 KIT MDM2 NRAS PDGFRA
7 limbs/digits/tail MP:0005371 9.77 FN1 KIT MDM2 NRAS PDGFRA
8 no phenotypic analysis MP:0003012 9.73 CD68 KIT MDM2 NRAS PDGFRA PTPRC
9 normal MP:0002873 9.63 FN1 KIT MDM2 NRAS PDGFRA PTPRC
10 pigmentation MP:0001186 9.26 KIT MDM2 NRAS PDGFRA
11 skeleton MP:0005390 9.17 CD68 FN1 KIT MDM2 NRAS PDGFRA

Drugs & Therapeutics for Conventional Fibrosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Fibrosarcoma

Genetic Tests for Conventional Fibrosarcoma

Anatomical Context for Conventional Fibrosarcoma

MalaCards organs/tissues related to Conventional Fibrosarcoma:

42
Lung, Skin, Liver, Bone, Myeloid, Breast, Brain

Publications for Conventional Fibrosarcoma

Variations for Conventional Fibrosarcoma

Expression for Conventional Fibrosarcoma

Search GEO for disease gene expression data for Conventional Fibrosarcoma.

Pathways for Conventional Fibrosarcoma

Pathways related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 CD34 CD68 FN1 KIT MDM2 NRAS
2
Show member pathways
13.19 CD34 KIT MDM2 NRAS PDGFRA PTPRC
3
Show member pathways
13.04 KIT NRAS PDGFRA PTPRC TNFRSF8
4
Show member pathways
12.8 FN1 KIT MDM2 NRAS PDGFRA
5
Show member pathways
12.71 FN1 KIT MDM2 NRAS PDGFRA
6
Show member pathways
12.61 KIT MDM2 NRAS PDGFRA
7
Show member pathways
12.49 KIT MDM2 NRAS PDGFRA
8
Show member pathways
12.39 CALD1 FN1 KIT NRAS PDGFRA TNFRSF8
9 12.38 FN1 KIT MDM2 NRAS PDGFRA
10 12.31 CD34 KIT PTPRC TNFRSF8
11 12.06 FN1 MDM2 NRAS
12 11.89 MDM2 NRAS PDGFRA
13 11.75 MDM2 NRAS PDGFRA
14 11.54 CD34 KIT PTPRC
15 11.5 CD34 KIT NRAS
16 11.45 CD34 KIT PTPRC
17 11.36 KIT NRAS PDGFRA
18 11.32 CD34 CD68 KIT PTPRC
19 10.65 CD34 KIT PTPRC TNFRSF8

GO Terms for Conventional Fibrosarcoma

Cellular components related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD34 KIT PDGFRA PTPRC
2 plasma membrane GO:0005886 9.32 CALD1 CD34 CD68 ENO2 KIT MDM2
3 external side of plasma membrane GO:0009897 9.26 CD34 KIT PDGFRA PTPRC

Biological processes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.56 FN1 KIT MDM2 PDGFRA
2 MAPK cascade GO:0000165 9.54 KIT NRAS PDGFRA
3 positive regulation of MAPK cascade GO:0043410 9.33 KIT PDGFRA PTPRC
4 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.32 KIT PDGFRA
5 positive regulation of gene expression GO:0010628 9.26 CD34 FN1 KIT MDM2
6 positive regulation of phospholipase C activity GO:0010863 8.62 KIT PDGFRA

Molecular functions related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.32 TNFRSF8

Sources for Conventional Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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