MCID: CNV003
MIFTS: 29

Conventional Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Conventional Fibrosarcoma

MalaCards integrated aliases for Conventional Fibrosarcoma:

Name: Conventional Fibrosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3517
NCIt 49 C9429
UMLS 71 C1333156

Summaries for Conventional Fibrosarcoma

MalaCards based summary : Conventional Fibrosarcoma is related to intravascular angioleiomyoma and breast myofibroblastoma. An important gene associated with Conventional Fibrosarcoma is SRMS (Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Conventional Fibrosarcoma

Diseases related to Conventional Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 intravascular angioleiomyoma 10.6 CD34 CALD1
2 breast myofibroblastoma 10.6 CD34 CALD1
3 penis sarcoma 10.6 ENO2 CD34
4 myoblastoma 10.6 ENO2 CD68
5 glomangiomyoma 10.6 CD34 CALD1
6 ovarian solid teratoma 10.6 TNFRSF8 CD34
7 nephrogenic adenofibroma 10.5 CD34 CALD1
8 glomangiosarcoma 10.5 CD34 CALD1
9 spermatic cord cancer 10.5 MYOD1 CD34
10 pacinian tumor 10.5 ENO2 CD34
11 urethra leiomyoma 10.5 KIT CALD1
12 primitive neuroectodermal tumor of the cervix uteri 10.5 PTPRC ENO2
13 spinal cord sarcoma 10.5 KIT CD34
14 malignant fibrous histiocytoma of bone 10.5 MYOD1 CALD1
15 uterine corpus sarcoma 10.5 KIT CALD1
16 gallbladder leiomyoma 10.5 KIT CD34
17 aortic malignant tumor 10.5 MDM2 CD34
18 intravenous leiomyomatosis 10.5 CD34 CALD1
19 small intestine leiomyosarcoma 10.5 KIT CD34
20 cerebellopontine angle primitive neuroectodermal tumor 10.5 PTPRC ENO2
21 congenital epulis 10.5 ENO2 CD68
22 reticular perineurioma 10.5 PDGFRA KIT
23 cervical polyp 10.5 CD34 CALD1
24 mucocele of appendix 10.5 KIT CD34
25 angiomyoma 10.5 ENO2 CD34 CALD1
26 sclerosing liposarcoma 10.5 MDM2 CD34
27 vulvar apocrine adenocarcinoma 10.5 PTPRC ENO2
28 sensory organ benign neoplasm 10.5 NRAS ENO2
29 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.5 TNFRSF8 PTPRC
30 epididymal neoplasm 10.5 MYOD1 CD68
31 cobblestone retinal degeneration 10.4 PTPRC CD68
32 prostate sarcoma 10.4 MYOD1 CD34
33 pulmonary vein leiomyosarcoma 10.4 MYOD1 CD34 CALD1
34 spindle cell liposarcoma 10.4 MDM2 CD34
35 pediatric liposarcoma 10.4 MDM2 CD34
36 breast lipoma 10.4 TNFRSF8 PTPRC
37 axillary lipoma 10.4 KIT CD68
38 adult fibrosarcoma 10.4 MYOD1 CD34 CALD1
39 ewing sarcoma of bone 10.4 PTPRC ENO2
40 undifferentiated embryonal sarcoma of the liver 10.4 MYOD1 MDM2
41 infiltrating lipoma 10.4 MDM2 CD34
42 central nervous system melanocytic neoplasm 10.4 NRAS ENO2
43 liver leiomyoma 10.4 KIT CD34
44 heart lymphoma 10.4 PTPRC CD68
45 benign mastocytoma 10.4 PTPRC KIT
46 malignant anus melanoma 10.4 NRAS KIT
47 inflammatory liposarcoma 10.4 MDM2 CD34
48 t-cell/histiocyte rich large b cell lymphoma 10.4 TNFRSF8 CD68
49 pyogenic granuloma 10.4 NRAS CD34
50 pulmonary vein stenosis 10.4 PDGFRA KIT

Graphical network of the top 20 diseases related to Conventional Fibrosarcoma:



Diseases related to Conventional Fibrosarcoma

Symptoms & Phenotypes for Conventional Fibrosarcoma

GenomeRNAi Phenotypes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.7 KIT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.7 CTNNB1 TNFRSF8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 9.7 CTNNB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.7 TNFRSF8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 PDGFRA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.7 TNFRSF8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.7 TNFRSF8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.7 KIT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.7 CTNNB1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.7 CTNNB1 KIT
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.7 CTNNB1 TNFRSF8
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-197 9.7 CTNNB1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.7 KIT
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.7 CTNNB1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.7 TNFRSF8
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.7 CTNNB1 TNFRSF8
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.7 CTNNB1 PDGFRA
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.7 CTNNB1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.7 CTNNB1

MGI Mouse Phenotypes related to Conventional Fibrosarcoma:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 CD34 CTNNB1 ENO2 FN1 KIT MB
2 hematopoietic system MP:0005397 10.37 CD34 CD68 CTNNB1 FN1 KIT MB
3 growth/size/body region MP:0005378 10.35 CTNNB1 ENO2 FN1 KIT MB MDM2
4 cardiovascular system MP:0005385 10.33 CTNNB1 FN1 KIT MB MDM2 MYOD1
5 homeostasis/metabolism MP:0005376 10.32 CD34 CTNNB1 FN1 KIT MB MDM2
6 immune system MP:0005387 10.31 CD34 CD68 CTNNB1 FN1 KIT MDM2
7 craniofacial MP:0005382 10.27 CTNNB1 ENO2 FN1 KIT MDM2 NRAS
8 embryo MP:0005380 10.26 CTNNB1 FN1 KIT MB MDM2 NRAS
9 endocrine/exocrine gland MP:0005379 10.25 CTNNB1 KIT MDM2 NRAS PAX3 PAX7
10 digestive/alimentary MP:0005381 10.22 CTNNB1 KIT MDM2 NRAS PAX3 PAX7
11 integument MP:0010771 10.22 CD34 CTNNB1 FN1 KIT MDM2 NRAS
12 neoplasm MP:0002006 10.15 CD34 CTNNB1 FN1 KIT MDM2 MYOD1
13 muscle MP:0005369 10.1 CTNNB1 FN1 KIT MB MDM2 MYOD1
14 limbs/digits/tail MP:0005371 10.06 CTNNB1 FN1 KIT MDM2 NRAS PAX3
15 no phenotypic analysis MP:0003012 10.06 CD68 CTNNB1 KIT MDM2 MYOD1 NRAS
16 liver/biliary system MP:0005370 10.03 CTNNB1 FN1 KIT MDM2 NRAS PAX3
17 normal MP:0002873 10.03 CTNNB1 FN1 KIT MDM2 MYOD1 NRAS
18 pigmentation MP:0001186 9.7 CTNNB1 KIT MDM2 NRAS PAX3 PDGFRA
19 respiratory system MP:0005388 9.65 CTNNB1 ENO2 KIT MB MYOD1 PAX3
20 skeleton MP:0005390 9.4 CD68 CTNNB1 FN1 KIT MDM2 MYOD1

Drugs & Therapeutics for Conventional Fibrosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Fibrosarcoma

Genetic Tests for Conventional Fibrosarcoma

Anatomical Context for Conventional Fibrosarcoma

Publications for Conventional Fibrosarcoma

Articles related to Conventional Fibrosarcoma:

# Title Authors PMID Year
1
The contribution of electron microscopy to the characterization of soft tissue fibrosarcomas. 61
23383612 2013
2
Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. 61
17513510 2008
3
[Sclerosing epithelioid fibrosarcoma: a clinicopathologic study of eight cases]. 61
15363319 2004
4
[Sclerosing epithelioid fibrosarcoma]. 61
11813633 2001
5
Ultrastructure of cellular congenital mesoblastic nephroma. 61
8883325 1996
6
Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. 61
7661286 1995
7
Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. 61
6310227 1983
8
Transformation of ameloblastic fibroma to fibrosarcoma. 61
102609 1978

Variations for Conventional Fibrosarcoma

Expression for Conventional Fibrosarcoma

Search GEO for disease gene expression data for Conventional Fibrosarcoma.

Pathways for Conventional Fibrosarcoma

Pathways related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 TP53 TNFRSF8 SRMS PTPRC PDGFRA NRAS
2
Show member pathways
13.34 TP53 SRMS PTPRC PDGFRA NRAS MDM2
3
Show member pathways
12.97 TP53 PTPRC NRAS MYOD1 FN1 CTNNB1
4
Show member pathways
12.96 TP53 PDGFRA NRAS MDM2 KIT FN1
5
Show member pathways
12.78 TP53 PDGFRA NRAS MDM2 KIT FN1
6
Show member pathways
12.75 TP53 PDGFRA NRAS MDM2 KIT CTNNB1
7
Show member pathways
12.73 PDGFRA NRAS KIT FN1 CALD1
8
Show member pathways
12.55 TP53 SRMS PDGFRA NRAS MDM2 KIT
9
Show member pathways
12.48 TP53 PDGFRA NRAS FN1 CTNNB1
10 12.42 TP53 PDGFRA NRAS MDM2 KIT FN1
11
Show member pathways
12.28 TP53 PDGFRA NRAS MDM2 CTNNB1
12 12.17 TP53 PAX7 PAX3 MDM2
13 12.08 TP53 NRAS MDM2 FN1 CTNNB1
14 11.89 TP53 NRAS MDM2 CTNNB1
15 11.86 PTPRC KIT CD68 CD34
16 11.84 TP53 NRAS MDM2 CTNNB1
17 11.69 PTPRC KIT CD34
18 11.65 PTPRC KIT CD34
19 11.64 TP53 NRAS MDM2
20 11.51 NRAS MYOD1 KIT CD34
21 11.5 PAX3 MYOD1 MDM2
22 11.4 TP53 PDGFRA NRAS KIT
23 11.4 TP53 PDGFRA NRAS MDM2 CTNNB1
24 11.15 PTPRC PAX7 PAX3 MYOD1 KIT FN1

GO Terms for Conventional Fibrosarcoma

Cellular components related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.8 PTPRC CTNNB1 CD34

Biological processes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 PDGFRA MDM2 KIT FN1 CTNNB1
2 regulation of gene expression GO:0010468 9.8 PTPRC PAX7 MYOD1 MDM2 CTNNB1
3 regulation of cell proliferation GO:0042127 9.76 TP53 SRMS KIT CTNNB1
4 hemopoiesis GO:0030097 9.67 KIT CTNNB1 CD34
5 positive regulation of gene expression GO:0010628 9.63 TP53 MDM2 KIT FN1 CTNNB1 CD34
6 T cell differentiation GO:0030217 9.54 PTPRC KIT CTNNB1
7 positive regulation of phospholipase C activity GO:0010863 9.52 PDGFRA KIT
8 bone marrow development GO:0048539 9.48 TP53 PTPRC
9 cellular response to UV-C GO:0071494 9.43 TP53 MDM2
10 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOD1 MDM2 CTNNB1
11 heart development GO:0007507 9.35 TP53 MDM2 MB FN1 CTNNB1
12 cellular response to actinomycin D GO:0072717 9.32 TP53 MDM2
13 hematopoietic progenitor cell differentiation GO:0002244 8.92 TP53 PTPRC PDGFRA KIT

Molecular functions related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.35 TP53 MYOD1 MDM2 FN1 CTNNB1
2 disordered domain specific binding GO:0097718 8.92 TP53 MDM2 FN1 CTNNB1

Sources for Conventional Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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