MCID: CNV003
MIFTS: 27

Conventional Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Conventional Fibrosarcoma

MalaCards integrated aliases for Conventional Fibrosarcoma:

Name: Conventional Fibrosarcoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3517
NCIt 50 C9429
UMLS 72 C1333156

Summaries for Conventional Fibrosarcoma

MalaCards based summary : Conventional Fibrosarcoma is related to pleomorphic liposarcoma and retroperitoneal fibrosis. An important gene associated with Conventional Fibrosarcoma is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are hematopoietic system and cellular

Related Diseases for Conventional Fibrosarcoma

Diseases related to Conventional Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 pleomorphic liposarcoma 10.6 PDGFRA MDM2
2 retroperitoneal fibrosis 10.6 PTPRC MDM2
3 reticular perineurioma 10.6 PDGFRA KIT
4 sm-ahnmd 10.6 PDGFRA KIT
5 primitive neuroectodermal tumor of the cervix uteri 10.5 PTPRC ENO2
6 desmoid tumor 10.5 PDGFRA KIT
7 gamma heavy chain disease 10.5 PTPRC NRAS
8 pulmonary vein stenosis 10.5 PDGFRA KIT
9 lung adenoid cystic carcinoma 10.5 PDGFRA KIT
10 hypereosinophilic syndrome, idiopathic 10.5 PDGFRA KIT
11 acral lentiginous melanoma 10.5 NRAS KIT
12 nodular ganglioneuroblastoma 10.5 MDM2 ENO2
13 kidney rhabdoid cancer 10.5 PTPRC ENO2
14 malignant spindle cell melanoma 10.5 NRAS KIT
15 meningeal melanomatosis 10.5 NRAS ENO2
16 carney triad 10.5 PDGFRA KIT
17 gastric small cell carcinoma 10.5 PTPRC ENO2
18 chronic eosinophilic leukemia 10.5 PDGFRA KIT
19 cutaneous ganglioneuroma 10.5 KIT ENO2
20 undifferentiated pleomorphic sarcoma 10.5 PDGFRA KIT
21 extraskeletal ewing sarcoma 10.5 PTPRC ENO2
22 connective tissue benign neoplasm 10.4 MDM2 ENO2
23 rete testis adenocarcinoma 10.4 KIT ENO2
24 prostate small cell carcinoma 10.4 KIT ENO2
25 congenital mesoblastic nephroma 10.4 NRAS KIT
26 melanomatosis 10.4 NRAS CD68
27 vulvar melanoma 10.4 NRAS KIT
28 nodular tenosynovitis 10.4 PTPRC CD68
29 malignant giant cell tumor of soft parts 10.4 PTPRC CD68
30 skin granular cell tumor 10.4 ENO2 CD68
31 granular cell tumor 10.4 ENO2 CD68
32 malignant fibrous histiocytoma of bone 10.4 MDM2 CALD1
33 brain sarcoma 10.4 PTPRC CD68
34 neurofibromatosis, type i 10.4 PDGFRA KIT
35 embryonal sarcoma 10.4 MDM2 KIT
36 rete testis neoplasm 10.4 KIT ENO2
37 mucosal melanoma 10.4 NRAS KIT
38 axillary lipoma 10.4 KIT CD68
39 core binding factor acute myeloid leukemia 10.4 NRAS KIT
40 fox-fordyce disease 10.3 KIT CD68
41 cloacogenic carcinoma 10.3 PTPRC ENO2
42 malignant skin fibrous histiocytoma 10.3 NRAS KIT
43 neurilemmoma of the fifth cranial nerve 10.3 PTPRC CD68
44 trigeminal nerve neoplasm 10.3 PTPRC CD68
45 sclerosing liposarcoma 10.3 MDM2 CD34
46 liver inflammatory pseudotumor 10.3 PTPRC CD34
47 photokeratitis 10.3 PTPRC CD68
48 myxosarcoma 10.3 MDM2 CD68
49 fibrosarcoma of bone 10.3 PDGFRA MDM2 KIT
50 malignant dermis tumor 10.3 NRAS KIT

Graphical network of the top 20 diseases related to Conventional Fibrosarcoma:



Diseases related to Conventional Fibrosarcoma

Symptoms & Phenotypes for Conventional Fibrosarcoma

MGI Mouse Phenotypes related to Conventional Fibrosarcoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 CD34 CD68 FN1 KIT MDM2 NRAS
2 cellular MP:0005384 10.1 CD34 ENO2 FN1 KIT MDM2 NRAS
3 immune system MP:0005387 10.09 CD34 CD68 FN1 KIT MDM2 NRAS
4 craniofacial MP:0005382 9.95 ENO2 FN1 KIT MDM2 NRAS PDGFRA
5 integument MP:0010771 9.88 CD34 FN1 KIT MDM2 NRAS PDGFRA
6 neoplasm MP:0002006 9.87 CD34 FN1 KIT MDM2 NRAS PDGFRA
7 limbs/digits/tail MP:0005371 9.77 FN1 KIT MDM2 NRAS PDGFRA
8 no phenotypic analysis MP:0003012 9.73 CD68 KIT MDM2 NRAS PDGFRA PTPRC
9 normal MP:0002873 9.63 FN1 KIT MDM2 NRAS PDGFRA PTPRC
10 pigmentation MP:0001186 9.26 KIT MDM2 NRAS PDGFRA
11 skeleton MP:0005390 9.17 CD68 FN1 KIT MDM2 NRAS PDGFRA

Drugs & Therapeutics for Conventional Fibrosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Fibrosarcoma

Genetic Tests for Conventional Fibrosarcoma

Anatomical Context for Conventional Fibrosarcoma

Publications for Conventional Fibrosarcoma

Articles related to Conventional Fibrosarcoma:

# Title Authors PMID Year
1
The contribution of electron microscopy to the characterization of soft tissue fibrosarcomas. 38
23383612 2013
2
Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. 38
17513510 2008
3
[Sclerosing epithelioid fibrosarcoma: a clinicopathologic study of eight cases]. 38
15363319 2004
4
[Sclerosing epithelioid fibrosarcoma]. 38
11813633 2001
5
Ultrastructure of cellular congenital mesoblastic nephroma. 38
8883325 1996
6
Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. 38
7661286 1995
7
Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. 38
6310227 1983
8
Transformation of ameloblastic fibroma to fibrosarcoma. 38
102609 1978

Variations for Conventional Fibrosarcoma

Expression for Conventional Fibrosarcoma

Search GEO for disease gene expression data for Conventional Fibrosarcoma.

Pathways for Conventional Fibrosarcoma

Pathways related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 TNFRSF8 PTPRC PDGFRA NRAS MDM2 KIT
2
Show member pathways
13.19 PTPRC PDGFRA NRAS MDM2 KIT CD34
3
Show member pathways
13.04 TNFRSF8 PTPRC PDGFRA NRAS KIT
4
Show member pathways
12.8 PDGFRA NRAS MDM2 KIT FN1
5
Show member pathways
12.71 PDGFRA NRAS MDM2 KIT FN1
6
Show member pathways
12.61 PDGFRA NRAS MDM2 KIT
7
Show member pathways
12.49 PDGFRA NRAS MDM2 KIT
8
Show member pathways
12.39 TNFRSF8 PDGFRA NRAS KIT FN1 CALD1
9 12.38 PDGFRA NRAS MDM2 KIT FN1
10 12.31 TNFRSF8 PTPRC KIT CD34
11 12.07 NRAS MDM2 FN1
12 11.89 PDGFRA NRAS MDM2
13 11.75 PDGFRA NRAS MDM2
14 11.54 PTPRC KIT CD34
15 11.5 NRAS KIT CD34
16 11.45 PTPRC KIT CD34
17 11.38 PDGFRA NRAS KIT
18 11.32 PTPRC KIT CD68 CD34
19 10.65 TNFRSF8 PTPRC KIT CD34

GO Terms for Conventional Fibrosarcoma

Cellular components related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 PTPRC PDGFRA KIT CD34
2 plasma membrane GO:0005886 9.32 TNFRSF8 PTPRC PDGFRA NRAS MDM2 KIT
3 external side of plasma membrane GO:0009897 9.26 PTPRC PDGFRA KIT CD34

Biological processes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.56 PDGFRA MDM2 KIT FN1
2 MAPK cascade GO:0000165 9.54 PDGFRA NRAS KIT
3 positive regulation of MAPK cascade GO:0043410 9.33 PTPRC PDGFRA KIT
4 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.32 PDGFRA KIT
5 positive regulation of gene expression GO:0010628 9.26 MDM2 KIT FN1 CD34
6 positive regulation of phospholipase C activity GO:0010863 8.62 PDGFRA KIT

Molecular functions related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.32 TNFRSF8

Sources for Conventional Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....