MCID: CNV003
MIFTS: 31

Conventional Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Conventional Fibrosarcoma

MalaCards integrated aliases for Conventional Fibrosarcoma:

Name: Conventional Fibrosarcoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3517
NCIt 50 C9429
UMLS 70 C1333156

Summaries for Conventional Fibrosarcoma

MalaCards based summary : Conventional Fibrosarcoma is related to glomangioma and intravascular angioleiomyoma. An important gene associated with Conventional Fibrosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway. Affiliated tissues include bone, breast and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Conventional Fibrosarcoma

Diseases related to Conventional Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
# Related Disease Score Top Affiliating Genes
1 glomangioma 10.5 CD34 CALD1
2 intravascular angioleiomyoma 10.4 CD34 CALD1
3 breast myofibroblastoma 10.4 CD34 CALD1
4 penis sarcoma 10.4 ENO2 CD34
5 glomangiomyoma 10.4 CD34 CALD1
6 vulvar leiomyosarcoma 10.4 CD34 CALD1
7 lung meningioma 10.4 ENO2 CD34
8 pacinian tumor 10.4 ENO2 CD34
9 myoblastoma 10.4 ENO2 CD68
10 peritoneal benign neoplasm 10.4 CD34 CALD1
11 ovarian solid teratoma 10.4 TNFRSF8 CD34
12 glomangiosarcoma 10.4 CD34 CALD1
13 spermatic cord cancer 10.4 MYOD1 CD34
14 psammomatous meningioma 10.4 ENO2 CD34
15 urethra leiomyoma 10.4 KIT CALD1
16 malignant fibrous histiocytoma of bone 10.4 MYOD1 CALD1
17 spinal cord sarcoma 10.4 KIT CD34
18 cervical polyp 10.4 CD34 CALD1
19 gallbladder leiomyoma 10.4 KIT CD34
20 testicular fibroma 10.4 CD34 CALD1
21 intravenous leiomyomatosis 10.4 CD34 CALD1
22 small intestine leiomyosarcoma 10.4 KIT CD34
23 subungual glomus tumor 10.4 CD34 CALD1
24 vulvar leiomyoma 10.4 CD34 CALD1
25 congenital epulis 10.4 ENO2 CD68
26 epulis 10.4 ENO2 CD68
27 primitive neuroectodermal tumor of the cervix uteri 10.4 PTPRC ENO2
28 mucocele of appendix 10.4 KIT CD34
29 benign fibrous mesothelioma 10.3 KIT CD34
30 reticular perineurioma 10.3 PDGFRA KIT
31 aortic malignant tumor 10.3 MDM2 CD34
32 liver fibroma 10.3 KIT CD34
33 sclerosing liposarcoma 10.3 MDM2 CD34
34 epididymal neoplasm 10.3 MYOD1 CD68
35 cerebellopontine angle primitive neuroectodermal tumor 10.3 PTPRC ENO2
36 axillary lipoma 10.3 KIT CD68
37 orbital cancer 10.3 ENO2 CD34
38 villonodular synovitis 10.3 PTPRC CD68
39 gastric hemangioma 10.3 KIT ENO2
40 vulvar apocrine adenocarcinoma 10.3 PTPRC ENO2
41 liver leiomyoma 10.3 KIT CD34
42 infiltrating lipoma 10.3 MDM2 CD34
43 spindle cell liposarcoma 10.3 MDM2 CD34
44 cobblestone retinal degeneration 10.3 PTPRC CD68
45 laryngeal small cell carcinoma 10.3 PDGFRA KIT
46 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.3 TNFRSF8 PTPRC
47 tibial nerve palsy 10.3 PTPRC CD34
48 benign mastocytoma 10.3 PTPRC KIT
49 breast lipoma 10.3 TNFRSF8 PTPRC
50 t-cell/histiocyte rich large b cell lymphoma 10.3 TNFRSF8 CD68

Graphical network of the top 20 diseases related to Conventional Fibrosarcoma:



Diseases related to Conventional Fibrosarcoma

Symptoms & Phenotypes for Conventional Fibrosarcoma

GenomeRNAi Phenotypes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.7 KIT
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.7 CTNNB1 TNFRSF8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 9.7 CTNNB1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.7 TNFRSF8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 PDGFRA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.7 TNFRSF8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.7 TNFRSF8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.7 KIT
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.7 CTNNB1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.7 CTNNB1 KIT
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.7 CTNNB1 TNFRSF8
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-197 9.7 CTNNB1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.7 KIT
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.7 CTNNB1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.7 TNFRSF8
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.7 CTNNB1 TNFRSF8
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.7 CTNNB1 PDGFRA
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.7 CTNNB1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.7 CTNNB1

MGI Mouse Phenotypes related to Conventional Fibrosarcoma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.38 CD34 CTNNB1 ENO2 FN1 KIT MB
2 cardiovascular system MP:0005385 10.35 CTNNB1 FN1 KIT MB MDM2 MYOD1
3 growth/size/body region MP:0005378 10.34 CTNNB1 ENO2 FN1 KIT MB MDM2
4 hematopoietic system MP:0005397 10.33 CD34 CD68 CTNNB1 FN1 KIT MB
5 homeostasis/metabolism MP:0005376 10.31 CD34 CTNNB1 FN1 KIT MB MDM2
6 immune system MP:0005387 10.3 CD34 CD68 CTNNB1 FN1 KIT MDM2
7 craniofacial MP:0005382 10.24 CTNNB1 ENO2 FN1 KIT MDM2 PAX3
8 embryo MP:0005380 10.23 CTNNB1 FN1 KIT MB MDM2 PAX3
9 endocrine/exocrine gland MP:0005379 10.22 CTNNB1 KIT MDM2 PAX3 PAX7 PDGFRA
10 integument MP:0010771 10.21 CD34 CTNNB1 FN1 KIT MDM2 PAX3
11 digestive/alimentary MP:0005381 10.19 CTNNB1 KIT MDM2 PAX3 PAX7 PDGFRA
12 neoplasm MP:0002006 10.17 CD34 CTNNB1 FN1 KIT MDM2 MYOD1
13 muscle MP:0005369 10.16 CTNNB1 FN1 KIT MB MDM2 MYOD1
14 nervous system MP:0003631 10.1 CTNNB1 ENO2 FN1 KIT MDM2 PAX3
15 no phenotypic analysis MP:0003012 10.07 CD68 CTNNB1 KIT MDM2 MYOD1 PAX3
16 limbs/digits/tail MP:0005371 10.04 CTNNB1 FN1 KIT MDM2 PAX3 PDGFRA
17 liver/biliary system MP:0005370 10.02 CTNNB1 FN1 KIT MDM2 PAX3 PTPRC
18 normal MP:0002873 10.02 CTNNB1 FN1 KIT MDM2 MYOD1 PAX3
19 pigmentation MP:0001186 9.73 CTNNB1 KIT MDM2 PAX3 PDGFRA TP53
20 renal/urinary system MP:0005367 9.7 CTNNB1 KIT MDM2 PAX3 PDGFRA PTPRC
21 respiratory system MP:0005388 9.65 CTNNB1 ENO2 KIT MB MYOD1 PAX3
22 skeleton MP:0005390 9.36 CD68 CTNNB1 FN1 KIT MDM2 MYOD1

Drugs & Therapeutics for Conventional Fibrosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Fibrosarcoma

Genetic Tests for Conventional Fibrosarcoma

Anatomical Context for Conventional Fibrosarcoma

MalaCards organs/tissues related to Conventional Fibrosarcoma:

40
Bone, Breast, Skin, Liver, Myeloid, Heart, Small Intestine

Publications for Conventional Fibrosarcoma

Articles related to Conventional Fibrosarcoma:

# Title Authors PMID Year
1
The contribution of electron microscopy to the characterization of soft tissue fibrosarcomas. 61
23383612 2013
2
Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review. 61
17513510 2008
3
[Sclerosing epithelioid fibrosarcoma: a clinicopathologic study of eight cases]. 61
15363319 2004
4
[Sclerosing epithelioid fibrosarcoma]. 61
11813633 2001
5
Ultrastructure of cellular congenital mesoblastic nephroma. 61
8883325 1996
6
Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. 61
7661286 1995
7
Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. 61
6310227 1983
8
Transformation of ameloblastic fibroma to fibrosarcoma. 61
102609 1978

Variations for Conventional Fibrosarcoma

Expression for Conventional Fibrosarcoma

Search GEO for disease gene expression data for Conventional Fibrosarcoma.

Pathways for Conventional Fibrosarcoma

Pathways related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 TP53 TNFRSF8 PTPRC PDGFRA MDM2 KIT
2
Show member pathways
12.63 TP53 PDGFRA MDM2 KIT FN1 CTNNB1
3
Show member pathways
12.42 TP53 PDGFRA FN1 CTNNB1
4 12.38 TNFRSF8 PTPRC KIT CD34
5
Show member pathways
12.25 TP53 PDGFRA MDM2 CTNNB1
6 12.16 TP53 PDGFRA MDM2 KIT FN1 CTNNB1
7 12.05 TP53 MDM2 FN1 CTNNB1
8 11.95 TP53 PAX7 PAX3 MDM2
9 11.81 TP53 MDM2 CTNNB1
10 11.76 TP53 MDM2 FN1
11 11.73 PAX7 PAX3 CTNNB1
12 11.62 PTPRC KIT CD68 CD34
13 11.59 PTPRC KIT CD34
14 11.56 MYOD1 KIT CD34
15 11.52 PTPRC KIT CD34
16 11.5 TP53 PDGFRA MDM2 CTNNB1
17 11.48 TP53 PDGFRA KIT
18 11.33 PAX3 MYOD1 MDM2
19 11.15 PTPRC PAX7 PAX3 MYOD1 KIT FN1

GO Terms for Conventional Fibrosarcoma

Cellular components related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.8 PTPRC CTNNB1 CD34

Biological processes related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.09 TP53 PAX7 PAX3 MYOD1 MDM2 KIT
2 viral process GO:0016032 9.89 TP53 PTPRC PDGFRA MDM2 CTNNB1
3 positive regulation of cell proliferation GO:0008284 9.88 PDGFRA MDM2 KIT FN1 CTNNB1
4 negative regulation of gene expression GO:0010629 9.87 TP53 MDM2 CTNNB1 CD34
5 muscle organ development GO:0007517 9.73 PAX7 PAX3 MYOD1
6 heart development GO:0007507 9.73 TP53 MDM2 FN1 CTNNB1
7 cell-matrix adhesion GO:0007160 9.7 FN1 CTNNB1 CD34
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 PDGFRA KIT FN1
9 cardiac septum morphogenesis GO:0060411 9.58 TP53 MDM2
10 hemopoiesis GO:0030097 9.58 KIT CTNNB1 CD34
11 positive regulation of phospholipase C activity GO:0010863 9.54 PDGFRA KIT
12 T cell differentiation GO:0030217 9.5 PTPRC KIT CTNNB1
13 bone marrow development GO:0048539 9.46 TP53 PTPRC
14 positive regulation of gene expression GO:0010628 9.43 TP53 MDM2 KIT FN1 CTNNB1 CD34
15 cellular response to UV-C GO:0071494 9.37 TP53 MDM2
16 positive regulation of muscle cell differentiation GO:0051149 9.33 MYOD1 MDM2 CTNNB1
17 cellular response to actinomycin D GO:0072717 9.26 TP53 MDM2
18 hematopoietic progenitor cell differentiation GO:0002244 8.92 TP53 PTPRC PDGFRA KIT

Molecular functions related to Conventional Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.56 TP53 MYOD1 CTNNB1 CD34
2 enzyme binding GO:0019899 9.35 TP53 MYOD1 MDM2 FN1 CTNNB1
3 protease binding GO:0002020 9.33 TP53 KIT FN1
4 disordered domain specific binding GO:0097718 8.92 TP53 MDM2 FN1 CTNNB1

Sources for Conventional Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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