MCID: CNV006
MIFTS: 30

Conventional Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5253
NCIt 50 C9428
UMLS 72 C1333157

Summaries for Conventional Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary : Conventional Leiomyosarcoma is related to hemophagocytic lymphohistiocytosis, familial, 1 and mesenchymoma. An important gene associated with Conventional Leiomyosarcoma is MYF6 (Myogenic Factor 6), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Immune response Function of MEF2 in T lymphocytes. Affiliated tissues include uterus and smooth muscle, and related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis, familial, 1 10.6 MYOD1 MYF6
2 mesenchymoma 10.6 MYOD1 HMGA2
3 pleomorphic rhabdomyosarcoma 10.6 PAX7 MYOD1
4 malignant triton tumor 10.5 NF1 MYOD1
5 pleomorphic adenoma carcinoma 10.4 TP53 HMGA2
6 well-differentiated liposarcoma 10.4 HMGA2 CDKN2A
7 atypical neurofibroma 10.4 NF1 CDKN2A
8 breast rhabdomyosarcoma 10.4 MYOG MYOD1
9 bladder squamous cell carcinoma 10.4 TP53 CDKN2A
10 keratinizing squamous cell carcinoma 10.4 TP53 CDKN2A
11 spitz nevus 10.4 TP53 CDKN2A
12 undifferentiated embryonal sarcoma of the liver 10.4 MYOG MYOD1
13 gallbladder sarcoma 10.4 MYOG MYOD1
14 gliofibroma 10.4 TP53 NF1
15 central nervous system mesenchymal non-meningothelial tumor 10.4 PAX7 MYOD1 MYF6
16 rhabdoid cancer 10.4 TP53 MYOD1
17 vulva squamous cell carcinoma 10.4 TP53 CDKN2A
18 nodular tenosynovitis 10.4 HMGA2 CD68
19 bartholin's gland disease 10.4 TP53 CDKN2A
20 nasal cavity adenocarcinoma 10.4 TP53 CDKN2A
21 vulvar disease 10.4 TP53 CDKN2A
22 thyroid lymphoma 10.4 TP53 CDKN2A
23 anal squamous cell carcinoma 10.4 TP53 CDKN2A
24 gastric adenosquamous carcinoma 10.3 TP53 CDKN2A
25 glycogen-rich clear cell breast carcinoma 10.3 TP53 CDKN2A
26 fallopian tube endometrioid adenocarcinoma 10.3 MYOG CDKN2A
27 megaesophagus 10.3 TP53 CDKN2A
28 oral leukoplakia 10.3 TP53 CDKN2A
29 uterus carcinoma in situ 10.3 TP53 CDKN2A
30 adult fibrosarcoma 10.3 MYOG MYOD1
31 cervix uteri carcinoma in situ 10.3 TP53 CDKN2A
32 orbit rhabdomyosarcoma 10.3 NF1 MYOG
33 lymphohistiocytoid mesothelioma 10.3 CDKN2A CD68
34 melanomatosis 10.3 CDKN2A CD68
35 anogenital venereal wart 10.3 TP53 CDKN2A
36 meningeal melanomatosis 10.3 TP53 CDKN2A
37 spindle cell liposarcoma 10.3 MYOG MYOD1
38 suppressor of tumorigenicity 3 10.3 TP53 CDKN2A
39 endocervical adenocarcinoma 10.3 TP53 CDKN2A
40 penile disease 10.2 TP53 CDKN2A
41 ischemic fasciitis 10.2 CDKN2A CD68
42 epithelial-myoepithelial carcinoma 10.2 TP53 HMGA2
43 cervix small cell carcinoma 10.2 TP53 CDKN2A
44 neurilemmoma of the fifth cranial nerve 10.2 NF1 CD68
45 trigeminal nerve neoplasm 10.2 NF1 CD68
46 basaloid squamous cell carcinoma 10.2 TP53 CDKN2A
47 verrucous carcinoma 10.2 TP53 CDKN2A
48 necrotizing sialometaplasia 10.2 TP53 CDKN2A
49 meningeal melanocytoma 10.1 CDKN2A CD68
50 tongue disease 10.1 TP53 CDKN2A

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:



Diseases related to Conventional Leiomyosarcoma

Symptoms & Phenotypes for Conventional Leiomyosarcoma

GenomeRNAi Phenotypes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 9.13 TP53
2 Decreased CDKN1A mRNA expression GR00389-S-2 9.13 HMGA2 TP53
3 Increased TP53 mRNA expression GR00389-S-6 8.62 HMGA2 TP53

MGI Mouse Phenotypes related to Conventional Leiomyosarcoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 CDKN2A ITGA7 MYF5 MYF6 MYOD1 MYOG
2 mortality/aging MP:0010768 10.09 CDKN2A ITGA7 MYF5 MYF6 MYOD1 MYOG
3 muscle MP:0005369 10.06 CDKN2A ITGA7 MYF5 MYF6 MYOD1 MYOG
4 embryo MP:0005380 10.02 CDKN2A MYF5 MYF6 MYOG NF1 PAX7
5 no phenotypic analysis MP:0003012 9.92 CD68 CDKN2A MYF5 MYF6 MYOD1 MYOG
6 neoplasm MP:0002006 9.91 CDKN2A MYF5 MYF6 MYOD1 NF1 PAX7
7 adipose tissue MP:0005375 9.89 MYF5 MYF6 MYOD1 MYOG TP53
8 normal MP:0002873 9.8 MYF5 MYF6 MYOD1 MYOG NF1 PAX7
9 respiratory system MP:0005388 9.76 CDKN2A MYF5 MYF6 MYOD1 MYOG NF1
10 skeleton MP:0005390 9.65 CD68 CDKN2A ITGA7 MYF5 MYF6 MYOD1
11 vision/eye MP:0005391 9.1 CDKN2A MYF5 MYF6 NF1 PAX7 TP53

Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Leiomyosarcoma

Genetic Tests for Conventional Leiomyosarcoma

Anatomical Context for Conventional Leiomyosarcoma

MalaCards organs/tissues related to Conventional Leiomyosarcoma:

41
Uterus, Smooth Muscle

Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

# Title Authors PMID Year
1
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. 38
28884746 2018
2
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. 38
27717885 2017
3
Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. 38
28174812 2016
4
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. 38
23019412 2012
5
AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. 38
21437186 2011
6
Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. 38
20462098 2010
7
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. 38
15864383 2005

Variations for Conventional Leiomyosarcoma

Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

Pathways for Conventional Leiomyosarcoma

GO Terms for Conventional Leiomyosarcoma

Cellular components related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.97 TP53 MYOG MYOD1 MYF6 HMGA2 CDKN2A
2 negative regulation of transcription, DNA-templated GO:0045892 9.95 TP53 MYF6 HMGA2 CDKN2A
3 negative regulation of cell proliferation GO:0008285 9.91 TP53 NF1 MYOG CDKN2A
4 positive regulation of apoptotic process GO:0043065 9.88 TP53 NF1 HMGA2 CDKN2A
5 extracellular matrix organization GO:0030198 9.83 NF1 MYF5 ITGA7
6 skeletal muscle cell differentiation GO:0035914 9.78 MYOG MYOD1 MYF6 MYF5
7 Ras protein signal transduction GO:0007265 9.74 TP53 NF1 CDKN2A
8 positive regulation of cell cycle arrest GO:0071158 9.71 TP53 MYOG HMGA2
9 positive regulation of muscle cell differentiation GO:0051149 9.71 MYOG MYOD1 MYF6 MYF5
10 skeletal muscle tissue regeneration GO:0043403 9.69 PAX7 MYOG MYF6
11 positive regulation of myoblast differentiation GO:0045663 9.67 MYOG MYOD1 MYF6 MYF5
12 negative regulation of fibroblast proliferation GO:0048147 9.64 TP53 NF1
13 endodermal cell differentiation GO:0035987 9.64 ITGA7 HMGA2
14 skeletal muscle fiber development GO:0048741 9.63 MYOG MYOD1
15 muscle organ development GO:0007517 9.63 PAX7 MYOG MYOD1 MYF6 MYF5 ITGA7
16 negative regulation of cell-matrix adhesion GO:0001953 9.62 NF1 CDKN2A
17 myoblast differentiation GO:0045445 9.62 MYOG MYOD1
18 positive regulation of myoblast fusion GO:1901741 9.62 MYOG MYOD1 MYF6 MYF5
19 positive regulation of cellular senescence GO:2000774 9.61 HMGA2 CDKN2A
20 muscle tissue morphogenesis GO:0060415 9.61 PAX7 MYF6 MYF5
21 replicative senescence GO:0090399 9.6 TP53 CDKN2A
22 regulation of cell-matrix adhesion GO:0001952 9.59 NF1 MYF5
23 myotube differentiation GO:0014902 9.58 MYOG MYOD1
24 positive regulation of skeletal muscle fiber development GO:0048743 9.56 MYOG MYOD1 MYF6 MYF5
25 senescence-associated heterochromatin focus assembly GO:0035986 9.55 HMGA2 CDKN2A
26 muscle cell fate commitment GO:0042693 9.26 MYOG MYOD1 MYF6 MYF5
27 skeletal muscle tissue development GO:0007519 9.1 PAX7 NF1 MYOG MYOD1 MYF6 MYF5
28 regulation of transcription, DNA-templated GO:0006355 10.1 TP53 PAX7 MYOG MYOD1 MYF6 MYF5
29 multicellular organism development GO:0007275 10.07 TP53 PAX7 MYOG MYOD1 MYF6 MYF5
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 TP53 PAX7 MYOG MYOD1 MYF6 MYF5
31 cell differentiation GO:0030154 10.03 TP53 MYOG MYOD1 MYF6 MYF5

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.87 TP53 PAX7 MYOG MYOD1 MYF6 MYF5
2 DNA binding GO:0003677 9.86 TP53 PAX7 MYOG MYOD1 MYF6 MYF5
3 DNA-binding transcription factor activity GO:0003700 9.85 TP53 PAX7 MYOG MYOD1 MYF6
4 protein heterodimerization activity GO:0046982 9.8 TP53 MYOG MYOD1 MYF6 MYF5
5 transcription factor binding GO:0008134 9.73 TP53 MYOD1 HMGA2 CDKN2A
6 protein dimerization activity GO:0046983 9.67 MYOG MYOD1 MYF6 MYF5
7 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.63 TP53 MYOG MYOD1 MYF6 MYF5 HMGA2
8 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.35 TP53 MYOG MYOD1 MYF6 MYF5
9 E-box binding GO:0070888 8.92 MYOG MYOD1 MYF6 MYF5

Sources for Conventional Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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