Conventional Leiomyosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma ¹¹ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5253

NCIt ⁴⁹ C9428

UMLS ⁷¹ C1333157

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Summaries for Conventional Leiomyosarcoma

Disease Ontology: ¹¹ A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary: Conventional Leiomyosarcoma is related to ureter leiomyoma and glomangiosarcoma. An important gene associated with Conventional Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Regulation of nuclear beta catenin signaling and target gene transcription and GPR143 in melanocytes and retinal pigment epithelium cells. Affiliated tissues include smooth muscle, uterus and skeletal muscle.

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Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)

#	Related Disease	Score	Top Affiliating Genes
1	ureter leiomyoma	10.2	MLANA CALD1
2	glomangiosarcoma	10.2	MLANA CALD1
3	ovarian melanoma	10.2	MLANA CALD1
4	vulvar leiomyosarcoma	10.2	MLANA CALD1
5	cutaneous leiomyosarcoma	10.2	MLANA CALD1
6	benign perivascular tumor	10.2	MLANA CALD1
7	bizarre leiomyoma	10.2	MLANA CALD1
8	prostate embryonal rhabdomyosarcoma	10.2	MYOG CALD1
9	glomangioma	10.2	MLANA CALD1
10	ovary leiomyosarcoma	10.2	MLANA CALD1
11	sarcomatosis	10.2	MYOG CALD1
12	scrotum neoplasm	10.2	MYOG CALD1
13	adult fibrosarcoma	10.2	MYOG CALD1
14	skin sarcoma	10.2	MLANA CALD1
15	cervical polyp	10.2	MYOG CALD1
16	malignant mesenchymoma	10.2	MYOG CALD1
17	testicular fibroma	10.2	MLANA CALD1
18	liver sarcoma	10.2	MYOG CALD1
19	cervical adenosarcoma	10.2	MYOG CALD1
20	solitary fibrous tumor/hemangiopericytoma	10.2	MLANA CALD1
21	malignant leptomeningeal tumor	10.2	MLANA MITF
22	infiltrating angiolipoma	10.2	MLANA CALD1
23	meningeal melanoma	10.2	MLANA MITF
24	pigmented basal cell carcinoma	10.2	MLANA MITF
25	hepatic angiomyolipoma	10.2	MLANA MITF
26	angiomyolipoma	10.2	MLANA MITF
27	sarcomatous intrahepatic cholangiocarcinoma	10.1	CALD1 ANO1
28	kidney leiomyosarcoma	10.1	CALD1 ANO1
29	gallbladder leiomyosarcoma	10.1	CALD1 ANO1
30	epithelioid type angiomyolipoma	10.1	MLANA MITF
31	deep leiomyoma	10.1	CALD1 ANO1
32	spinal cord melanoma	10.1	MLANA MITF
33	gastric leiomyosarcoma	10.1	CALD1 ANO1
34	colon leiomyosarcoma	10.1	CALD1 ANO1
35	angiomyoma	10.1	CALD1 ANO1
36	gastric leiomyoma	10.1	CALD1 ANO1
37	retroperitoneal leiomyosarcoma	10.1	CALD1 ANO1
38	cervix melanoma	10.1	MLANA MITF
39	epithelioid cell melanoma	10.1	MLANA MITF
40	subungual glomus tumor	10.1	TLE1 CALD1
41	gallbladder melanoma	10.1	MLANA MITF
42	infantile myofibromatosis	10.1	MYOG CALD1
43	malignant glandular tumor of peripheral nerve sheath	10.1	TLE1 MYOG
44	endometrial stromal tumor	10.1	MLANA CALD1
45	acral lentiginous melanoma	10.1	MLANA MITF
46	gastric liposarcoma	10.1	CALD1 ANO1
47	malignant granular cell myoblastoma	10.1	MLANA ANO1
48	gastric hemangioma	10.1	CALD1 ANO1
49	pulmonary artery leiomyosarcoma	10.1	CALD1 ANO1
50	prostate stromal sarcoma	10.1	MYOG ANO1

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:

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Symptoms & Phenotypes for Conventional Leiomyosarcoma

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Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials, NIH Clinical Center for Conventional Leiomyosarcoma

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Genetic Tests for Conventional Leiomyosarcoma

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Anatomical Context for Conventional Leiomyosarcoma

Organs/tissues related to Conventional Leiomyosarcoma:

MalaCards : Smooth Muscle, Uterus, Skeletal Muscle

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Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

#	Title	Authors	PMID	Year
1	Uterine Leiomyosarcoma Masquerading as a Malignant Perivascular Epithelioid Cell Tumor: A Diagnostic Challenge. ⁶²	Natsume T...Kato T	36310451	2022
2	Inflammatory leiomyosarcoma of the head and neck: Case report. ⁶²	Viljoen N...Govender D	33934064	2021
3	Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor. ⁶²	Michal M...Michal M	32078043	2020
4	Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. ⁶²	Arbajian E...Mertens F	28884746	2018
5	Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. ⁶²	Lu B...Zhang X	27717885	2017
6	Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. ⁶²	Wincewicz A...Woltanowska M	28174812	2016
7	Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. ⁶²	Nord KH...Mertens F	23019412	2012
8	AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. ⁶²	Purgina B...Pantanowitz L	21437186	2011
9	Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. ⁶²	Sukpan K...Siriaunkgul S	20462098	2010
10	So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. ⁶²	Chang A...Rubin BP	15864383	2005

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Genes for Conventional Leiomyosarcoma

Genes related to Conventional Leiomyosarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CALD1	Caldesmon 1	Protein Coding	5.9	DISEASES inferred ¹⁴
2	MLANA	Melan-A	Protein Coding	5.34	DISEASES inferred ¹⁴
3	MYOG	Myogenin	Protein Coding	5.22	DISEASES inferred ¹⁴
4	ZC3HAV1L	Zinc Finger CCCH-Type Containing, Antiviral 1 Like	Protein Coding	4.95	DISEASES inferred ¹⁴
5	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	4.77	DISEASES inferred ¹⁴
6	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	4.64	DISEASES inferred ¹⁴
7	PAX7	Paired Box 7	Protein Coding	4.6	DISEASES inferred ¹⁴
8	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	4.58	DISEASES inferred ¹⁴
9	ANO1	Anoctamin 1	Protein Coding	4.56	DISEASES inferred ¹⁴

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Variations for Conventional Leiomyosarcoma

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Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

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Pathways for Conventional Leiomyosarcoma

Pathways related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of nuclear beta catenin signaling and target gene transcription ⁶¹	10.66	TLE1 MYOG MITF
2	GPR143 in melanocytes and retinal pigment epithelium cells ⁷⁴	10.4	MLANA MITF

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GO Terms for Conventional Leiomyosarcoma

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein dimerization activity	GO:0046983	9.02	MYOG MITF ANO1

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Sources for Conventional Leiomyosarcoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CNV006 MIFTS: 21	Conventional Leiomyosarcoma Categories: Cancer diseases, Muscle diseases	Data Licensing For inquiries, contact: [email protected]
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