Conventional Leiomyosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma ¹² ¹⁵ ⁷²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5253

NCIt ⁵⁰ C9428

UMLS ⁷² C1333157

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Summaries for Conventional Leiomyosarcoma

Disease Ontology : ¹² A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary : Conventional Leiomyosarcoma is related to hemophagocytic lymphohistiocytosis, familial, 1 and mesenchymoma. An important gene associated with Conventional Leiomyosarcoma is MYF6 (Myogenic Factor 6), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Immune response Function of MEF2 in T lymphocytes. Affiliated tissues include uterus and smooth muscle, and related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

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Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)

#	Related Disease	Score	Top Affiliating Genes
1	hemophagocytic lymphohistiocytosis, familial, 1	10.6	MYOD1 MYF6
2	mesenchymoma	10.6	MYOD1 HMGA2
3	pleomorphic rhabdomyosarcoma	10.6	PAX7 MYOD1
4	malignant triton tumor	10.5	NF1 MYOD1
5	pleomorphic adenoma carcinoma	10.4	TP53 HMGA2
6	well-differentiated liposarcoma	10.4	HMGA2 CDKN2A
7	atypical neurofibroma	10.4	NF1 CDKN2A
8	breast rhabdomyosarcoma	10.4	MYOG MYOD1
9	bladder squamous cell carcinoma	10.4	TP53 CDKN2A
10	keratinizing squamous cell carcinoma	10.4	TP53 CDKN2A
11	spitz nevus	10.4	TP53 CDKN2A
12	undifferentiated embryonal sarcoma of the liver	10.4	MYOG MYOD1
13	gallbladder sarcoma	10.4	MYOG MYOD1
14	gliofibroma	10.4	TP53 NF1
15	central nervous system mesenchymal non-meningothelial tumor	10.4	PAX7 MYOD1 MYF6
16	rhabdoid cancer	10.4	TP53 MYOD1
17	vulva squamous cell carcinoma	10.4	TP53 CDKN2A
18	nodular tenosynovitis	10.4	HMGA2 CD68
19	bartholin's gland disease	10.4	TP53 CDKN2A
20	nasal cavity adenocarcinoma	10.4	TP53 CDKN2A
21	vulvar disease	10.4	TP53 CDKN2A
22	thyroid lymphoma	10.4	TP53 CDKN2A
23	anal squamous cell carcinoma	10.4	TP53 CDKN2A
24	gastric adenosquamous carcinoma	10.3	TP53 CDKN2A
25	glycogen-rich clear cell breast carcinoma	10.3	TP53 CDKN2A
26	fallopian tube endometrioid adenocarcinoma	10.3	MYOG CDKN2A
27	megaesophagus	10.3	TP53 CDKN2A
28	oral leukoplakia	10.3	TP53 CDKN2A
29	uterus carcinoma in situ	10.3	TP53 CDKN2A
30	adult fibrosarcoma	10.3	MYOG MYOD1
31	cervix uteri carcinoma in situ	10.3	TP53 CDKN2A
32	orbit rhabdomyosarcoma	10.3	NF1 MYOG
33	lymphohistiocytoid mesothelioma	10.3	CDKN2A CD68
34	melanomatosis	10.3	CDKN2A CD68
35	anogenital venereal wart	10.3	TP53 CDKN2A
36	meningeal melanomatosis	10.3	TP53 CDKN2A
37	spindle cell liposarcoma	10.3	MYOG MYOD1
38	suppressor of tumorigenicity 3	10.3	TP53 CDKN2A
39	endocervical adenocarcinoma	10.3	TP53 CDKN2A
40	penile disease	10.2	TP53 CDKN2A
41	ischemic fasciitis	10.2	CDKN2A CD68
42	epithelial-myoepithelial carcinoma	10.2	TP53 HMGA2
43	cervix small cell carcinoma	10.2	TP53 CDKN2A
44	neurilemmoma of the fifth cranial nerve	10.2	NF1 CD68
45	trigeminal nerve neoplasm	10.2	NF1 CD68
46	basaloid squamous cell carcinoma	10.2	TP53 CDKN2A
47	verrucous carcinoma	10.2	TP53 CDKN2A
48	necrotizing sialometaplasia	10.2	TP53 CDKN2A
49	meningeal melanocytoma	10.1	CDKN2A CD68
50	tongue disease	10.1	TP53 CDKN2A

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:

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Symptoms & Phenotypes for Conventional Leiomyosarcoma

GenomeRNAi Phenotypes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased CDKN1A mRNA expression	GR00389-S-1	9.13	TP53
2	Decreased CDKN1A mRNA expression	GR00389-S-2	9.13	HMGA2 TP53
3	Increased TP53 mRNA expression	GR00389-S-6	8.62	HMGA2 TP53

MGI Mouse Phenotypes related to Conventional Leiomyosarcoma:

⁴⁶ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.11	CDKN2A ITGA7 MYF5 MYF6 MYOD1 MYOG
2	mortality/aging	MP:0010768	10.09	CDKN2A ITGA7 MYF5 MYF6 MYOD1 MYOG
3	muscle	MP:0005369	10.06	CDKN2A ITGA7 MYF5 MYF6 MYOD1 MYOG
4	embryo	MP:0005380	10.02	CDKN2A MYF5 MYF6 MYOG NF1 PAX7
5	no phenotypic analysis	MP:0003012	9.92	CD68 CDKN2A MYF5 MYF6 MYOD1 MYOG
6	neoplasm	MP:0002006	9.91	CDKN2A MYF5 MYF6 MYOD1 NF1 PAX7
7	adipose tissue	MP:0005375	9.89	MYF5 MYF6 MYOD1 MYOG TP53
8	normal	MP:0002873	9.8	MYF5 MYF6 MYOD1 MYOG NF1 PAX7
9	respiratory system	MP:0005388	9.76	CDKN2A MYF5 MYF6 MYOD1 MYOG NF1
10	skeleton	MP:0005390	9.65	CD68 CDKN2A ITGA7 MYF5 MYF6 MYOD1
11	vision/eye	MP:0005391	9.1	CDKN2A MYF5 MYF6 NF1 PAX7 TP53

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Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Leiomyosarcoma

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Genetic Tests for Conventional Leiomyosarcoma

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Anatomical Context for Conventional Leiomyosarcoma

MalaCards organs/tissues related to Conventional Leiomyosarcoma:

⁴¹

Uterus, Smooth Muscle

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Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

#	Title	Authors	PMID	Year
1	Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. ³⁸	Arbajian E...Mertens F	28884746	2018
2	Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. ³⁸	Lu B...Zhang X	27717885	2017
3	Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. ³⁸	Wincewicz A...Woltanowska M	28174812	2016
4	Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. ³⁸	Nord KH...Mertens F	23019412	2012
5	AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. ³⁸	Purgina B...Pantanowitz L	21437186	2011
6	Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. ³⁸	Sukpan K...Siriaunkgul S	20462098	2010
7	So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. ³⁸	Chang A...Rubin BP	15864383	2005

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Genes for Conventional Leiomyosarcoma

Genes related to Conventional Leiomyosarcoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYF6	Myogenic Factor 6	Protein Coding	15.98	DISEASES inferred ¹⁵
2	ITGA7	Integrin Subunit Alpha 7	Protein Coding	15.97	DISEASES inferred ¹⁵
3	PAX7	Paired Box 7	Protein Coding	14.94	DISEASES inferred ¹⁵
4	MYOD1	Myogenic Differentiation 1	Protein Coding	14.46	DISEASES inferred ¹⁵
5	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	14.26	DISEASES inferred ¹⁵
6	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.91	DISEASES inferred ¹⁵
7	NF1	Neurofibromin 1	Protein Coding	13.38	DISEASES inferred ¹⁵
8	TP53	Tumor Protein P53	Protein Coding	13.1	DISEASES inferred ¹⁵
9	MYOG	Myogenin	Protein Coding	5.51	DISEASES inferred ¹⁵
10	MYF5	Myogenic Factor 5	Protein Coding	5.43	DISEASES inferred ¹⁵
11	CALD1	Caldesmon 1	Protein Coding	4.63	DISEASES inferred ¹⁵
12	CD68	CD68 Molecule	Protein Coding	3.36	DISEASES inferred ¹⁵

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Variations for Conventional Leiomyosarcoma

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Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

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Pathways for Conventional Leiomyosarcoma

Pathways related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional misregulation in cancer ³⁷	11.81	TP53 PAX7 HMGA2
2	Immune response Function of MEF2 in T lymphocytes ²² Show member pathways Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis ²²	11.65	MYOG MYOD1 MYF6
3	Glioblastoma Multiforme ⁶⁴	11.18	TP53 NF1 CDKN2A
4	Oncogene Induced Senescence ⁶⁶	10.91	TP53 CDKN2A
5	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	10.6	TP53 CDKN2A
6	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.5	TP53 CDKN2A
7	miRs in Muscle Cell Differentiation ¹	10.36	PAX7 MYOD1 MYF5

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GO Terms for Conventional Leiomyosarcoma

Cellular components related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	senescence-associated heterochromatin focus	GO:0035985	8.62	HMGA2 CDKN2A

Biological processes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.97	TP53 MYOG MYOD1 MYF6 HMGA2 CDKN2A
2	negative regulation of transcription, DNA-templated	GO:0045892	9.95	TP53 MYF6 HMGA2 CDKN2A
3	negative regulation of cell proliferation	GO:0008285	9.91	TP53 NF1 MYOG CDKN2A
4	positive regulation of apoptotic process	GO:0043065	9.88	TP53 NF1 HMGA2 CDKN2A
5	extracellular matrix organization	GO:0030198	9.83	NF1 MYF5 ITGA7
6	skeletal muscle cell differentiation	GO:0035914	9.78	MYOG MYOD1 MYF6 MYF5
7	Ras protein signal transduction	GO:0007265	9.74	TP53 NF1 CDKN2A
8	positive regulation of cell cycle arrest	GO:0071158	9.71	TP53 MYOG HMGA2
9	positive regulation of muscle cell differentiation	GO:0051149	9.71	MYOG MYOD1 MYF6 MYF5
10	skeletal muscle tissue regeneration	GO:0043403	9.69	PAX7 MYOG MYF6
11	positive regulation of myoblast differentiation	GO:0045663	9.67	MYOG MYOD1 MYF6 MYF5
12	negative regulation of fibroblast proliferation	GO:0048147	9.64	TP53 NF1
13	endodermal cell differentiation	GO:0035987	9.64	ITGA7 HMGA2
14	skeletal muscle fiber development	GO:0048741	9.63	MYOG MYOD1
15	muscle organ development	GO:0007517	9.63	PAX7 MYOG MYOD1 MYF6 MYF5 ITGA7
16	negative regulation of cell-matrix adhesion	GO:0001953	9.62	NF1 CDKN2A
17	myoblast differentiation	GO:0045445	9.62	MYOG MYOD1
18	positive regulation of myoblast fusion	GO:1901741	9.62	MYOG MYOD1 MYF6 MYF5
19	positive regulation of cellular senescence	GO:2000774	9.61	HMGA2 CDKN2A
20	muscle tissue morphogenesis	GO:0060415	9.61	PAX7 MYF6 MYF5
21	replicative senescence	GO:0090399	9.6	TP53 CDKN2A
22	regulation of cell-matrix adhesion	GO:0001952	9.59	NF1 MYF5
23	myotube differentiation	GO:0014902	9.58	MYOG MYOD1
24	positive regulation of skeletal muscle fiber development	GO:0048743	9.56	MYOG MYOD1 MYF6 MYF5
25	senescence-associated heterochromatin focus assembly	GO:0035986	9.55	HMGA2 CDKN2A
26	muscle cell fate commitment	GO:0042693	9.26	MYOG MYOD1 MYF6 MYF5
27	skeletal muscle tissue development	GO:0007519	9.1	PAX7 NF1 MYOG MYOD1 MYF6 MYF5
28	regulation of transcription, DNA-templated	GO:0006355	10.1	TP53 PAX7 MYOG MYOD1 MYF6 MYF5
29	multicellular organism development	GO:0007275	10.07	TP53 PAX7 MYOG MYOD1 MYF6 MYF5
30	positive regulation of transcription by RNA polymerase II	GO:0045944	10.06	TP53 PAX7 MYOG MYOD1 MYF6 MYF5
31	cell differentiation	GO:0030154	10.03	TP53 MYOG MYOD1 MYF6 MYF5

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.87	TP53 PAX7 MYOG MYOD1 MYF6 MYF5
2	DNA binding	GO:0003677	9.86	TP53 PAX7 MYOG MYOD1 MYF6 MYF5
3	DNA-binding transcription factor activity	GO:0003700	9.85	TP53 PAX7 MYOG MYOD1 MYF6
4	protein heterodimerization activity	GO:0046982	9.8	TP53 MYOG MYOD1 MYF6 MYF5
5	transcription factor binding	GO:0008134	9.73	TP53 MYOD1 HMGA2 CDKN2A
6	protein dimerization activity	GO:0046983	9.67	MYOG MYOD1 MYF6 MYF5
7	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.63	TP53 MYOG MYOD1 MYF6 MYF5 HMGA2
8	DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001228	9.35	TP53 MYOG MYOD1 MYF6 MYF5
9	E-box binding	GO:0070888	8.92	MYOG MYOD1 MYF6 MYF5

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Sources for Conventional Leiomyosarcoma

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