Conventional Leiomyosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5253

NCIt ⁴⁹ C9428

UMLS ⁷¹ C1333157

Sources

Summaries for Conventional Leiomyosarcoma

Disease Ontology : ¹² A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary : Conventional Leiomyosarcoma is related to lung combined type small cell carcinoma and cervical polyp. An important gene associated with Conventional Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Affiliated tissues include uterus, smooth muscle and skeletal muscle, and related phenotypes are growth/size/body region and muscle

Sources

Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Related Disease	Score	Top Affiliating Genes
1	lung combined type small cell carcinoma	10.2	MYOG CALD1
2	cervical polyp	10.2	MYOG CALD1
3	extraosseous osteosarcoma	10.2	MYOG CALD1
4	endobronchial leiomyoma	10.2	MYOG CALD1
5	retroperitoneal sarcoma	10.2	MYOG CALD1
6	uterus leiomyosarcoma	10.1	MYOG CALD1
7	vagina sarcoma	10.1	MYOG CALD1
8	myofibroma	10.1	MYOG CALD1
9	orbit embryonal rhabdomyosarcoma	10.1	PAX7 MYOG
10	pseudosarcomatous fibromatosis	10.1	MYOG CALD1
11	parameningeal embryonal rhabdomyosarcoma	10.1	PAX7 MYOG
12	mixed cell type cancer	10.1	MYOG CALD1
13	clear cell basal cell carcinoma	10.1	PAX7 MYOG
14	hemangiopericytoma, malignant	10.1	MYOG CALD1
15	mesenchymal cell neoplasm	10.1	MYOG CALD1
16	cardiovascular cancer	10.0	MYOG CALD1
17	vascular cancer	10.0	MYOG CALD1
18	well-differentiated liposarcoma	10.0	MYOG CALD1
19	myxofibrosarcoma	10.0	MYOG CALD1
20	pulmonary vein leiomyosarcoma	9.9	MYOD1 CALD1
21	dedifferentiated liposarcoma	9.9	MYOG CALD1
22	breast rhabdomyosarcoma	9.9	MYOG MYOD1
23	malignant fibrous histiocytoma of bone	9.9	MYOD1 CALD1
24	undifferentiated embryonal sarcoma of the liver	9.9	MYOG MYOD1
25	embryonal sarcoma	9.9	MYOG MYOD1
26	pineal region teratoma	9.9	MYOG MYOD1
27	skeletal muscle neoplasm	9.9	MYOG MYOD1
28	gallbladder sarcoma	9.9	MYOG MYOD1
29	prostate rhabdomyosarcoma	9.9	MYOG MYOD1
30	malignant fibrous histiocytoma	9.9	MYOG MYOD1
31	prostate sarcoma	9.8	MYOG MYOD1
32	malignant triton tumor	9.8	MYOG MYOD1
33	botryoid rhabdomyosarcoma	9.8	MYOG MYOD1
34	prostate stromal sarcoma	9.8	MYOG MYOD1
35	inflammatory myofibroblastic tumor	9.8	MYOG CALD1
36	extraosseous ewing sarcoma	9.8	MYOG MYOD1
37	bethlem myopathy 1	9.8	PAX7 ITGA7
38	horner's syndrome	9.8	MYOG MYOD1
39	gas gangrene	9.8	MYOG MYOD1
40	myopathy, congenital	9.8	PAX7 MYOG ITGA7
41	mesenchymal chondrosarcoma	9.8	MYOG MYOD1
42	prostate embryonal rhabdomyosarcoma	9.6	MYOG MYOD1 CALD1
43	adult fibrosarcoma	9.6	MYOG MYOD1 CALD1
44	malignant mesenchymoma	9.6	MYOG MYOD1 CALD1
45	conventional fibrosarcoma	9.6	PAX7 MYOD1 CALD1
46	embryonal rhabdomyosarcoma	9.6	PAX7 MYOG MYOD1
47	central nervous system mesenchymal non-meningothelial tumor	9.6	PAX7 MYOG MYOD1
48	spindle cell rhabdomyosarcoma	9.5	PAX7 MYOG MYOD1
49	x-linked monogenic disease	9.5	PAX7 MYOG MYOD1
50	ullrich congenital muscular dystrophy 1	9.5	PAX7 MYOD1 ITGA7

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:

Sources

Symptoms & Phenotypes for Conventional Leiomyosarcoma

MGI Mouse Phenotypes related to Conventional Leiomyosarcoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.88	ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7
2	muscle	MP:0005369	9.85	ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7
3	adipose tissue	MP:0005375	9.73	MYF5 MYF6 MYOD1 MYOG
4	no phenotypic analysis	MP:0003012	9.65	MYF5 MYF6 MYOD1 MYOG PAX7
5	neoplasm	MP:0002006	9.62	MYF5 MYF6 MYOD1 PAX7
6	normal	MP:0002873	9.55	MYF5 MYF6 MYOD1 MYOG PAX7
7	respiratory system	MP:0005388	9.35	MYF5 MYF6 MYOD1 MYOG PAX7
8	skeleton	MP:0005390	9.1	ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7

Sources

Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Leiomyosarcoma

Sources

Genetic Tests for Conventional Leiomyosarcoma

Sources

Anatomical Context for Conventional Leiomyosarcoma

MalaCards organs/tissues related to Conventional Leiomyosarcoma:

⁴⁰

Uterus, Smooth Muscle, Skeletal Muscle

Sources

Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

#	Title	Authors	PMID	Year
1	Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor. ⁶¹	Michal M...Michal M	32078043	2020
2	Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. ⁶¹	Arbajian E...Mertens F	28884746	2018
3	Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. ⁶¹	Lu B...Zhang X	27717885	2017
4	Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. ⁶¹	Wincewicz A...Woltanowska M	28174812	2016
5	Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. ⁶¹	Nord KH...Mertens F	23019412	2012
6	AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. ⁶¹	Purgina B...Pantanowitz L	21437186	2011
7	Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. ⁶¹	Sukpan K...Siriaunkgul S	20462098	2010
8	So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. ⁶¹	Chang A...Rubin BP	15864383	2005

Sources

Genes for Conventional Leiomyosarcoma

Genes related to Conventional Leiomyosarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CALD1	Caldesmon 1	Protein Coding	6.27	DISEASES inferred ¹⁵
2	MYOG	Myogenin	Protein Coding	5.86	DISEASES inferred ¹⁵
3	PAX7	Paired Box 7	Protein Coding	5.62	DISEASES inferred ¹⁵
4	ITGA7	Integrin Subunit Alpha 7	Protein Coding	5.57	DISEASES inferred ¹⁵
5	MYF6	Myogenic Factor 6	Protein Coding	5.43	DISEASES inferred ¹⁵
6	MYOD1	Myogenic Differentiation 1	Protein Coding	5.23	DISEASES inferred ¹⁵
7	MYF5	Myogenic Factor 5	Protein Coding	5.01	DISEASES inferred ¹⁵

Sources

Variations for Conventional Leiomyosarcoma

Sources

Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

Sources

Pathways for Conventional Leiomyosarcoma

Pathways related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁴	11.23	PAX7 MYOG MYOD1 MYF5
2	Regulation of Wnt-mediated beta catenin signaling and target gene transcription ¹	11.15	MYOG MYF5
3	C-MYB transcription factor network ¹	11.05	MYOD1 MYF6
4	Myogenesis ⁶⁵ Show member pathways CDO in myogenesis ⁶⁵	10.69	MYOG MYOD1 MYF6 MYF5

Sources

GO Terms for Conventional Leiomyosarcoma

Cellular components related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II transcription factor complex	GO:0090575	9.16	MYF6 MYF5
2	nuclear chromatin	GO:0000790	9.02	PAX7 MYOG MYOD1 MYF6 MYF5
3	myofibril	GO:0030016	8.96	MYOD1 CALD1

Biological processes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.95	PAX7 MYOG MYOD1 MYF6 MYF5
2	multicellular organism development	GO:0007275	9.91	PAX7 MYOG MYOD1 MYF6 MYF5
3	positive regulation of transcription by RNA polymerase II	GO:0045944	9.89	PAX7 MYOG MYOD1 MYF6 MYF5
4	cell differentiation	GO:0030154	9.88	MYOG MYOD1 MYF6 MYF5
5	skeletal muscle cell differentiation	GO:0035914	9.73	MYOG MYOD1 MYF6 MYF5
6	positive regulation of muscle cell differentiation	GO:0051149	9.71	MYOG MYOD1 MYF6 MYF5
7	positive regulation of myoblast differentiation	GO:0045663	9.67	MYOG MYOD1 MYF6 MYF5
8	skeletal muscle tissue regeneration	GO:0043403	9.65	PAX7 MYOG MYF6
9	skeletal muscle tissue development	GO:0007519	9.65	PAX7 MYOG MYOD1 MYF6 MYF5
10	muscle tissue morphogenesis	GO:0060415	9.63	PAX7 MYF6 MYF5
11	positive regulation of myoblast fusion	GO:1901741	9.62	MYOG MYOD1 MYF6 MYF5
12	somitogenesis	GO:0001756	9.58	MYF6 MYF5
13	cellular response to estradiol stimulus	GO:0071392	9.57	MYOG MYOD1
14	skeletal muscle fiber development	GO:0048741	9.56	MYOG MYOD1
15	myoblast differentiation	GO:0045445	9.54	MYOG MYOD1
16	myotube differentiation	GO:0014902	9.52	MYOG MYOD1
17	positive regulation of skeletal muscle fiber development	GO:0048743	9.46	MYOG MYOD1 MYF6 MYF5
18	muscle cell fate commitment	GO:0042693	9.26	MYOG MYOD1 MYF6 MYF5
19	muscle organ development	GO:0007517	9.1	PAX7 MYOG MYOD1 MYF6 MYF5 ITGA7

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.83	PAX7 MYOG MYOD1 MYF6 MYF5
2	DNA-binding transcription factor activity	GO:0003700	9.71	PAX7 MYOG MYOD1 MYF6
3	sequence-specific DNA binding	GO:0043565	9.67	PAX7 MYOG MYOD1 MYF5
4	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.62	MYOG MYOD1 MYF6 MYF5
5	DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001228	9.56	MYOG MYOD1 MYF6 MYF5
6	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.55	PAX7 MYOG MYOD1 MYF6 MYF5
7	proximal promoter sequence-specific DNA binding	GO:0000987	9.48	MYOG MYOD1
8	chromatin DNA binding	GO:0031490	9.46	MYOG MYOD1
9	protein dimerization activity	GO:0046983	9.26	MYOG MYOD1 MYF6 MYF5
10	E-box binding	GO:0070888	8.92	MYOG MYOD1 MYF6 MYF5

Sources

Sources for Conventional Leiomyosarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia