MCID: CNV006
MIFTS: 26

Conventional Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5253
NCIt 49 C9428
UMLS 71 C1333157

Summaries for Conventional Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary : Conventional Leiomyosarcoma is related to lung combined type small cell carcinoma and vagina leiomyosarcoma. An important gene associated with Conventional Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Neural Crest Differentiation and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Affiliated tissues include uterus and smooth muscle, and related phenotypes are growth/size/body region and embryo

Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 lung combined type small cell carcinoma 10.1 MYOG CALD1
2 vagina leiomyosarcoma 10.1 MYOG CALD1
3 sarcomatoid squamous cell skin carcinoma 10.1 MYOG CALD1
4 adult fibrosarcoma 10.1 MYOG CALD1
5 prostate embryonal rhabdomyosarcoma 10.1 MYOG CALD1
6 cervical polyp 10.1 MYOG CALD1
7 extraosseous osteosarcoma 10.1 MYOG CALD1
8 malignant mesenchymoma 10.1 MYOG CALD1
9 mesenchymoma 10.1 MYOG CALD1
10 retroperitoneal sarcoma 10.1 MYOG CALD1
11 endobronchial leiomyoma 10.1 MYOG CALD1
12 vagina sarcoma 10.1 MYOG CALD1
13 uterus leiomyosarcoma 10.0 MYOG CALD1
14 conventional fibrosarcoma 10.0 PAX7 CALD1
15 central nervous system mesenchymal non-meningothelial tumor 10.0 PAX7 MYOG
16 orbit embryonal rhabdomyosarcoma 10.0 PAX7 MYOG
17 embryonal rhabdomyosarcoma 10.0 PAX7 MYOG
18 pseudosarcomatous fibromatosis 10.0 MYOG CALD1
19 infantile myofibromatosis 9.9 MYOG CALD1
20 parameningeal embryonal rhabdomyosarcoma 9.9 PAX7 MYOG
21 spindle cell rhabdomyosarcoma 9.9 PAX7 MYOG
22 mesenchymal cell neoplasm 9.9 MYOG CALD1
23 clear cell basal cell carcinoma 9.9 PAX7 MYOG
24 mixed cell type cancer 9.9 MYOG CALD1
25 uterus perivascular epithelioid cell tumor 9.9 MITF CALD1
26 perivascular epithelioid cell tumor 9.9 MITF CALD1
27 myopathy of extraocular muscle 9.9 PAX7 MYOG
28 gas gangrene 9.9 PAX7 MYOG
29 bethlem myopathy 1 9.8 PAX7 ITGA7
30 inflammatory leiomyosarcoma 9.8 MYOG MYF6 ITGA7
31 dermis tumor 9.8 MITF CALD1
32 congenital fiber-type disproportion 9.8 MYF6 ITGA7
33 myopathy, congenital 9.7 PAX7 MYOG ITGA7
34 pleomorphic rhabdomyosarcoma 9.7 PAX7 MYOG MYF6
35 muscular dystrophy, congenital, lmna-related 9.7 PAX7 MYOG ITGA7
36 hemophagocytic lymphohistiocytosis, familial, 1 9.6 MYOG MYF6 MYF5
37 alveolar soft part sarcoma 9.6 MYOG MYF6 MYF5
38 x-linked recessive disease 9.5 PAX7 MYOG MYF5
39 facioscapulohumeral muscular dystrophy 1 9.5 PAX7 MYOG MYF5
40 muscle tissue disease 9.5 PAX7 MYOG MYF5
41 histiocytoma 9.5 MYOG MITF
42 cardiovascular cancer 9.5 MYOG MITF CALD1
43 vascular cancer 9.5 MYOG MITF CALD1
44 x-linked monogenic disease 9.5 PAX7 MYOG
45 waardenburg's syndrome 9.3 PAX7 MYF5 MITF
46 skeletal muscle cancer 9.2 PAX7 MYOG MYF6 MYF5
47 rhabdomyosarcoma 2 9.2 PAX7 MYOG MYF6 MYF5
48 rhabdomyosarcoma 9.2 PAX7 MYOG MYF6 MYF5
49 muscle cancer 8.9 PAX7 MYOG MYF6 MYF5 CALD1
50 muscular disease 8.6 PAX7 MYOG MYF6 MYF5 ITGA7 CALD1

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:



Diseases related to Conventional Leiomyosarcoma

Symptoms & Phenotypes for Conventional Leiomyosarcoma

MGI Mouse Phenotypes related to Conventional Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 ITGA7 MITF MYF5 MYF6 MYOG PAX7
2 embryo MP:0005380 9.8 MITF MYF5 MYF6 MYOG PAX7
3 muscle MP:0005369 9.72 ITGA7 MYF5 MYF6 MYOG PAX7
4 no phenotypic analysis MP:0003012 9.65 MITF MYF5 MYF6 MYOG PAX7
5 normal MP:0002873 9.55 MITF MYF5 MYF6 MYOG PAX7
6 respiratory system MP:0005388 9.26 MYF5 MYF6 MYOG PAX7
7 skeleton MP:0005390 9.1 ITGA7 MITF MYF5 MYF6 MYOG PAX7

Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Leiomyosarcoma

Genetic Tests for Conventional Leiomyosarcoma

Anatomical Context for Conventional Leiomyosarcoma

MalaCards organs/tissues related to Conventional Leiomyosarcoma:

40
Uterus, Smooth Muscle

Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

# Title Authors PMID Year
1
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. 61
28884746 2018
2
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. 61
27717885 2017
3
Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. 61
28174812 2016
4
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. 61
23019412 2012
5
AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. 61
21437186 2011
6
Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. 61
20462098 2010
7
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. 61
15864383 2005

Variations for Conventional Leiomyosarcoma

Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

Pathways for Conventional Leiomyosarcoma

Pathways related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.27 PAX7 MITF
2 11.03 MYOG MYF5 MITF
3 10.71 PAX7 MYF5
4
Show member pathways
10.56 MYOG MYF6 MYF5

GO Terms for Conventional Leiomyosarcoma

Cellular components related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.02 PAX7 MYOG MYF6 MYF5 MITF
2 RNA polymerase II transcription factor complex GO:0090575 8.96 MYF6 MYF5

Biological processes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.92 PAX7 MYOG MYF6 MYF5 MITF
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 PAX7 MYOG MYF6 MYF5 MITF
3 multicellular organism development GO:0007275 9.89 PAX7 MYOG MYF6 MYF5 MITF
4 cell differentiation GO:0030154 9.84 MYOG MYF6 MYF5 MITF
5 skeletal muscle cell differentiation GO:0035914 9.65 MYOG MYF6 MYF5
6 positive regulation of muscle cell differentiation GO:0051149 9.63 MYOG MYF6 MYF5
7 skeletal muscle tissue regeneration GO:0043403 9.61 PAX7 MYOG MYF6
8 positive regulation of myoblast differentiation GO:0045663 9.58 MYOG MYF6 MYF5
9 ossification GO:0001503 9.57 MYOG MYF5
10 camera-type eye development GO:0043010 9.56 MYF5 MITF
11 skeletal muscle tissue development GO:0007519 9.56 PAX7 MYOG MYF6 MYF5
12 somitogenesis GO:0001756 9.55 MYF6 MYF5
13 positive regulation of myoblast fusion GO:1901741 9.54 MYOG MYF6 MYF5
14 positive regulation of skeletal muscle fiber development GO:0048743 9.5 MYOG MYF6 MYF5
15 muscle tissue morphogenesis GO:0060415 9.33 PAX7 MYF6 MYF5
16 muscle cell fate commitment GO:0042693 9.13 MYOG MYF6 MYF5
17 muscle organ development GO:0007517 9.02 PAX7 MYOG MYF6 MYF5 ITGA7

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.8 PAX7 MYOG MYF6 MYF5 MITF
2 DNA-binding transcription factor activity GO:0003700 9.67 PAX7 MYOG MYF6 MITF
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.62 MYOG MYF6 MYF5 MITF
4 protein heterodimerization activity GO:0046982 9.61 MYOG MYF6 MYF5
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.56 MYOG MYF6 MYF5 MITF
6 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.55 PAX7 MYOG MYF6 MYF5 MITF
7 protein dimerization activity GO:0046983 9.26 MYOG MYF6 MYF5 MITF
8 E-box binding GO:0070888 8.92 MYOG MYF6 MYF5 MITF

Sources for Conventional Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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