MCID: CNV006
MIFTS: 27

Conventional Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5253
NCIt 49 C9428
UMLS 71 C1333157

Summaries for Conventional Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary : Conventional Leiomyosarcoma is related to lung combined type small cell carcinoma and cervical polyp. An important gene associated with Conventional Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Affiliated tissues include uterus, smooth muscle and skeletal muscle, and related phenotypes are growth/size/body region and muscle

Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 lung combined type small cell carcinoma 10.2 MYOG CALD1
2 cervical polyp 10.2 MYOG CALD1
3 extraosseous osteosarcoma 10.2 MYOG CALD1
4 endobronchial leiomyoma 10.2 MYOG CALD1
5 retroperitoneal sarcoma 10.2 MYOG CALD1
6 uterus leiomyosarcoma 10.1 MYOG CALD1
7 vagina sarcoma 10.1 MYOG CALD1
8 myofibroma 10.1 MYOG CALD1
9 orbit embryonal rhabdomyosarcoma 10.1 PAX7 MYOG
10 pseudosarcomatous fibromatosis 10.1 MYOG CALD1
11 parameningeal embryonal rhabdomyosarcoma 10.1 PAX7 MYOG
12 mixed cell type cancer 10.1 MYOG CALD1
13 clear cell basal cell carcinoma 10.1 PAX7 MYOG
14 hemangiopericytoma, malignant 10.1 MYOG CALD1
15 mesenchymal cell neoplasm 10.1 MYOG CALD1
16 cardiovascular cancer 10.0 MYOG CALD1
17 vascular cancer 10.0 MYOG CALD1
18 well-differentiated liposarcoma 10.0 MYOG CALD1
19 myxofibrosarcoma 10.0 MYOG CALD1
20 pulmonary vein leiomyosarcoma 9.9 MYOD1 CALD1
21 dedifferentiated liposarcoma 9.9 MYOG CALD1
22 breast rhabdomyosarcoma 9.9 MYOG MYOD1
23 malignant fibrous histiocytoma of bone 9.9 MYOD1 CALD1
24 undifferentiated embryonal sarcoma of the liver 9.9 MYOG MYOD1
25 embryonal sarcoma 9.9 MYOG MYOD1
26 pineal region teratoma 9.9 MYOG MYOD1
27 skeletal muscle neoplasm 9.9 MYOG MYOD1
28 gallbladder sarcoma 9.9 MYOG MYOD1
29 prostate rhabdomyosarcoma 9.9 MYOG MYOD1
30 malignant fibrous histiocytoma 9.9 MYOG MYOD1
31 prostate sarcoma 9.8 MYOG MYOD1
32 malignant triton tumor 9.8 MYOG MYOD1
33 botryoid rhabdomyosarcoma 9.8 MYOG MYOD1
34 prostate stromal sarcoma 9.8 MYOG MYOD1
35 inflammatory myofibroblastic tumor 9.8 MYOG CALD1
36 extraosseous ewing sarcoma 9.8 MYOG MYOD1
37 bethlem myopathy 1 9.8 PAX7 ITGA7
38 horner's syndrome 9.8 MYOG MYOD1
39 gas gangrene 9.8 MYOG MYOD1
40 myopathy, congenital 9.8 PAX7 MYOG ITGA7
41 mesenchymal chondrosarcoma 9.8 MYOG MYOD1
42 prostate embryonal rhabdomyosarcoma 9.6 MYOG MYOD1 CALD1
43 adult fibrosarcoma 9.6 MYOG MYOD1 CALD1
44 malignant mesenchymoma 9.6 MYOG MYOD1 CALD1
45 conventional fibrosarcoma 9.6 PAX7 MYOD1 CALD1
46 embryonal rhabdomyosarcoma 9.6 PAX7 MYOG MYOD1
47 central nervous system mesenchymal non-meningothelial tumor 9.6 PAX7 MYOG MYOD1
48 spindle cell rhabdomyosarcoma 9.5 PAX7 MYOG MYOD1
49 x-linked monogenic disease 9.5 PAX7 MYOG MYOD1
50 ullrich congenital muscular dystrophy 1 9.5 PAX7 MYOD1 ITGA7

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:



Diseases related to Conventional Leiomyosarcoma

Symptoms & Phenotypes for Conventional Leiomyosarcoma

MGI Mouse Phenotypes related to Conventional Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.88 ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7
2 muscle MP:0005369 9.85 ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7
3 adipose tissue MP:0005375 9.73 MYF5 MYF6 MYOD1 MYOG
4 no phenotypic analysis MP:0003012 9.65 MYF5 MYF6 MYOD1 MYOG PAX7
5 neoplasm MP:0002006 9.62 MYF5 MYF6 MYOD1 PAX7
6 normal MP:0002873 9.55 MYF5 MYF6 MYOD1 MYOG PAX7
7 respiratory system MP:0005388 9.35 MYF5 MYF6 MYOD1 MYOG PAX7
8 skeleton MP:0005390 9.1 ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7

Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Conventional Leiomyosarcoma

Genetic Tests for Conventional Leiomyosarcoma

Anatomical Context for Conventional Leiomyosarcoma

MalaCards organs/tissues related to Conventional Leiomyosarcoma:

40
Uterus, Smooth Muscle, Skeletal Muscle

Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

# Title Authors PMID Year
1
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor. 61
32078043 2020
2
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. 61
28884746 2018
3
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. 61
27717885 2017
4
Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. 61
28174812 2016
5
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. 61
23019412 2012
6
AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. 61
21437186 2011
7
Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. 61
20462098 2010
8
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. 61
15864383 2005

Variations for Conventional Leiomyosarcoma

Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

Pathways for Conventional Leiomyosarcoma

Pathways related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 PAX7 MYOG MYOD1 MYF5
2 11.15 MYOG MYF5
3 11.05 MYOD1 MYF6
4
Show member pathways
10.69 MYOG MYOD1 MYF6 MYF5

GO Terms for Conventional Leiomyosarcoma

Cellular components related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 9.16 MYF6 MYF5
2 nuclear chromatin GO:0000790 9.02 PAX7 MYOG MYOD1 MYF6 MYF5
3 myofibril GO:0030016 8.96 MYOD1 CALD1

Biological processes related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.95 PAX7 MYOG MYOD1 MYF6 MYF5
2 multicellular organism development GO:0007275 9.91 PAX7 MYOG MYOD1 MYF6 MYF5
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.89 PAX7 MYOG MYOD1 MYF6 MYF5
4 cell differentiation GO:0030154 9.88 MYOG MYOD1 MYF6 MYF5
5 skeletal muscle cell differentiation GO:0035914 9.73 MYOG MYOD1 MYF6 MYF5
6 positive regulation of muscle cell differentiation GO:0051149 9.71 MYOG MYOD1 MYF6 MYF5
7 positive regulation of myoblast differentiation GO:0045663 9.67 MYOG MYOD1 MYF6 MYF5
8 skeletal muscle tissue regeneration GO:0043403 9.65 PAX7 MYOG MYF6
9 skeletal muscle tissue development GO:0007519 9.65 PAX7 MYOG MYOD1 MYF6 MYF5
10 muscle tissue morphogenesis GO:0060415 9.63 PAX7 MYF6 MYF5
11 positive regulation of myoblast fusion GO:1901741 9.62 MYOG MYOD1 MYF6 MYF5
12 somitogenesis GO:0001756 9.58 MYF6 MYF5
13 cellular response to estradiol stimulus GO:0071392 9.57 MYOG MYOD1
14 skeletal muscle fiber development GO:0048741 9.56 MYOG MYOD1
15 myoblast differentiation GO:0045445 9.54 MYOG MYOD1
16 myotube differentiation GO:0014902 9.52 MYOG MYOD1
17 positive regulation of skeletal muscle fiber development GO:0048743 9.46 MYOG MYOD1 MYF6 MYF5
18 muscle cell fate commitment GO:0042693 9.26 MYOG MYOD1 MYF6 MYF5
19 muscle organ development GO:0007517 9.1 PAX7 MYOG MYOD1 MYF6 MYF5 ITGA7

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.83 PAX7 MYOG MYOD1 MYF6 MYF5
2 DNA-binding transcription factor activity GO:0003700 9.71 PAX7 MYOG MYOD1 MYF6
3 sequence-specific DNA binding GO:0043565 9.67 PAX7 MYOG MYOD1 MYF5
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.62 MYOG MYOD1 MYF6 MYF5
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.56 MYOG MYOD1 MYF6 MYF5
6 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.55 PAX7 MYOG MYOD1 MYF6 MYF5
7 proximal promoter sequence-specific DNA binding GO:0000987 9.48 MYOG MYOD1
8 chromatin DNA binding GO:0031490 9.46 MYOG MYOD1
9 protein dimerization activity GO:0046983 9.26 MYOG MYOD1 MYF6 MYF5
10 E-box binding GO:0070888 8.92 MYOG MYOD1 MYF6 MYF5

Sources for Conventional Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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