MCID: CNV006
MIFTS: 21

Conventional Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases
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Aliases & Classifications for Conventional Leiomyosarcoma

MalaCards integrated aliases for Conventional Leiomyosarcoma:

Name: Conventional Leiomyosarcoma 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5253
NCIt 49 C9428
UMLS 71 C1333157

Summaries for Conventional Leiomyosarcoma

Disease Ontology: 11 A leiomyosarcoma that is not histologically defined as spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or myxoid leiomyosarcoma.

MalaCards based summary: Conventional Leiomyosarcoma is related to ureter leiomyoma and glomangiosarcoma. An important gene associated with Conventional Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Regulation of nuclear beta catenin signaling and target gene transcription and GPR143 in melanocytes and retinal pigment epithelium cells. Affiliated tissues include smooth muscle, uterus and skeletal muscle.

Related Diseases for Conventional Leiomyosarcoma

Diseases related to Conventional Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 ureter leiomyoma 10.2 MLANA CALD1
2 glomangiosarcoma 10.2 MLANA CALD1
3 ovarian melanoma 10.2 MLANA CALD1
4 vulvar leiomyosarcoma 10.2 MLANA CALD1
5 cutaneous leiomyosarcoma 10.2 MLANA CALD1
6 benign perivascular tumor 10.2 MLANA CALD1
7 bizarre leiomyoma 10.2 MLANA CALD1
8 prostate embryonal rhabdomyosarcoma 10.2 MYOG CALD1
9 glomangioma 10.2 MLANA CALD1
10 ovary leiomyosarcoma 10.2 MLANA CALD1
11 sarcomatosis 10.2 MYOG CALD1
12 scrotum neoplasm 10.2 MYOG CALD1
13 adult fibrosarcoma 10.2 MYOG CALD1
14 skin sarcoma 10.2 MLANA CALD1
15 cervical polyp 10.2 MYOG CALD1
16 malignant mesenchymoma 10.2 MYOG CALD1
17 testicular fibroma 10.2 MLANA CALD1
18 liver sarcoma 10.2 MYOG CALD1
19 cervical adenosarcoma 10.2 MYOG CALD1
20 solitary fibrous tumor/hemangiopericytoma 10.2 MLANA CALD1
21 malignant leptomeningeal tumor 10.2 MLANA MITF
22 infiltrating angiolipoma 10.2 MLANA CALD1
23 meningeal melanoma 10.2 MLANA MITF
24 pigmented basal cell carcinoma 10.2 MLANA MITF
25 hepatic angiomyolipoma 10.2 MLANA MITF
26 angiomyolipoma 10.2 MLANA MITF
27 sarcomatous intrahepatic cholangiocarcinoma 10.1 CALD1 ANO1
28 kidney leiomyosarcoma 10.1 CALD1 ANO1
29 gallbladder leiomyosarcoma 10.1 CALD1 ANO1
30 epithelioid type angiomyolipoma 10.1 MLANA MITF
31 deep leiomyoma 10.1 CALD1 ANO1
32 spinal cord melanoma 10.1 MLANA MITF
33 gastric leiomyosarcoma 10.1 CALD1 ANO1
34 colon leiomyosarcoma 10.1 CALD1 ANO1
35 angiomyoma 10.1 CALD1 ANO1
36 gastric leiomyoma 10.1 CALD1 ANO1
37 retroperitoneal leiomyosarcoma 10.1 CALD1 ANO1
38 cervix melanoma 10.1 MLANA MITF
39 epithelioid cell melanoma 10.1 MLANA MITF
40 subungual glomus tumor 10.1 TLE1 CALD1
41 gallbladder melanoma 10.1 MLANA MITF
42 infantile myofibromatosis 10.1 MYOG CALD1
43 malignant glandular tumor of peripheral nerve sheath 10.1 TLE1 MYOG
44 endometrial stromal tumor 10.1 MLANA CALD1
45 acral lentiginous melanoma 10.1 MLANA MITF
46 gastric liposarcoma 10.1 CALD1 ANO1
47 malignant granular cell myoblastoma 10.1 MLANA ANO1
48 gastric hemangioma 10.1 CALD1 ANO1
49 pulmonary artery leiomyosarcoma 10.1 CALD1 ANO1
50 prostate stromal sarcoma 10.1 MYOG ANO1

Graphical network of the top 20 diseases related to Conventional Leiomyosarcoma:



Diseases related to Conventional Leiomyosarcoma

Symptoms & Phenotypes for Conventional Leiomyosarcoma

Drugs & Therapeutics for Conventional Leiomyosarcoma

Search Clinical Trials, NIH Clinical Center for Conventional Leiomyosarcoma

Genetic Tests for Conventional Leiomyosarcoma

Anatomical Context for Conventional Leiomyosarcoma

Organs/tissues related to Conventional Leiomyosarcoma:

MalaCards : Smooth Muscle, Uterus, Skeletal Muscle

Publications for Conventional Leiomyosarcoma

Articles related to Conventional Leiomyosarcoma:

# Title Authors PMID Year
1
Uterine Leiomyosarcoma Masquerading as a Malignant Perivascular Epithelioid Cell Tumor: A Diagnostic Challenge. 62
36310451 2022
2
Inflammatory leiomyosarcoma of the head and neck: Case report. 62
33934064 2021
3
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor. 62
32078043 2020
4
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. 62
28884746 2018
5
Myxoid leiomyosarcoma of the uterus: a clinicopathological and immunohistochemical study of 10 cases. 62
27717885 2017
6
Leiomyosarcoma FNCLCC G3 pT2B of broad ligament adherent to right oviduct - case report with molecular profiling. 62
28174812 2016
7
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. 62
23019412 2012
8
AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases. 62
21437186 2011
9
Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. 62
20462098 2010
10
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. 62
15864383 2005

Variations for Conventional Leiomyosarcoma

Expression for Conventional Leiomyosarcoma

Search GEO for disease gene expression data for Conventional Leiomyosarcoma.

Pathways for Conventional Leiomyosarcoma

Pathways related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 TLE1 MYOG MITF
2 10.4 MLANA MITF

GO Terms for Conventional Leiomyosarcoma

Molecular functions related to Conventional Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 9.02 MYOG MITF ANO1

Sources for Conventional Leiomyosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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