MCID: CPP004
MIFTS: 23

Copper Deficiency Myelopathy

Categories: Metabolic diseases

Aliases & Classifications for Copper Deficiency Myelopathy

MalaCards integrated aliases for Copper Deficiency Myelopathy:

Name: Copper Deficiency Myelopathy 12 15
Human Swayback 12
Swayback 45

Classifications:



External Ids:

Disease Ontology 12 DOID:5112
MeSH 45 D013540
SNOMED-CT 69 78714004
UMLS 74 C0038981

Summaries for Copper Deficiency Myelopathy

Disease Ontology : 12 A nutritional deficiency disease that is characterized by deficiency of copper, causing spastic gait and ataxia, often with anemia and neutropenia, has symptom imbalance and jerking movements, and has material basis in copper deficiency possibly due to malabsorption or excess zinc ingestion.

MalaCards based summary : Copper Deficiency Myelopathy, also known as human swayback, is related to multiple sclerosis and demyelinating disease, and has symptoms including imbalance An important gene associated with Copper Deficiency Myelopathy is AHCY (Adenosylhomocysteinase), and among its related pathways/superpathways are One carbon pool by folate and Selenium Micronutrient Network. Affiliated tissues include brain.

Related Diseases for Copper Deficiency Myelopathy

Diseases related to Copper Deficiency Myelopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 10.2
2 demyelinating disease 10.2
3 encephalitis 10.2
4 menkes disease 10.1
5 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.9
6 spondylosis, cervical 9.9
7 celiac disease 1 9.9
8 yemenite deaf-blind hypopigmentation syndrome 9.9
9 keratomalacia 9.9
10 spondylosis 9.9
11 night blindness 9.9
12 vascular disease 9.7 ALB MTR
13 wilson disease 9.6 ALB ATP7A
14 homocysteinemia 9.3 AHCY ALB MTR

Graphical network of the top 20 diseases related to Copper Deficiency Myelopathy:



Diseases related to Copper Deficiency Myelopathy

Symptoms & Phenotypes for Copper Deficiency Myelopathy

Symptoms:

12
  • imbalance

Drugs & Therapeutics for Copper Deficiency Myelopathy

Search Clinical Trials , NIH Clinical Center for Copper Deficiency Myelopathy

Cochrane evidence based reviews: swayback

Genetic Tests for Copper Deficiency Myelopathy

Anatomical Context for Copper Deficiency Myelopathy

MalaCards organs/tissues related to Copper Deficiency Myelopathy:

42
Brain

Publications for Copper Deficiency Myelopathy

Articles related to Copper Deficiency Myelopathy:

(show all 17)
# Title Authors Year
1
Copper Deficiency Myelopathy After Upper Gastrointestinal Surgery. ( 28659010 )
2018
2
Subacute copper-deficiency myelopathy in a patient with occult celiac disease. ( 27841075 )
2017
3
Zinc containing dental fixative causing copper deficiency myelopathy. ( 28790120 )
2017
4
Copper deficiency myelopathy in the setting of advanced degenerative cervical spondylosis. ( 26337459 )
2016
5
Copper deficiency myelopathy: A report of two cases. ( 25343982 )
2015
6
PPIs as possible risk factor for copper deficiency myelopathy. ( 25598493 )
2015
7
Night blindness due to vitamin A deficiency associated with copper deficiency myelopathy secondary to bowel bypass surgery. ( 24781845 )
2014
8
Copper deficiency myelopathy can also involve the brain stem. ( 20947641 )
2011
9
Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy. ( 21660014 )
2011
10
Copper deficiency myelopathy. ( 20232210 )
2010
11
Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar? ( 18472229 )
2008
12
Imaging features of copper deficiency myelopathy: a study of 25 cases. ( 16261334 )
2006
13
Mutation in the ATP7A gene may not be responsible for hypocupraemia in copper deficiency myelopathy. ( 16754714 )
2006
14
Copper deficiency myelopathy induced by repetitive parenteral zinc supplementation during chronic hemodialysis. ( 16972121 )
2006
15
Copper deficiency myelopathy (human swayback). ( 17036563 )
2006
16
Copper deficiency myelopathy. ( 15148156 )
2004
17
Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. ( 15249607 )
2004

Variations for Copper Deficiency Myelopathy

Expression for Copper Deficiency Myelopathy

Search GEO for disease gene expression data for Copper Deficiency Myelopathy.

GO Terms for Copper Deficiency Myelopathy

Biological processes related to Copper Deficiency Myelopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylation GO:0032259 8.62 AHCY MTR

Molecular functions related to Copper Deficiency Myelopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.96 ALB ATP7A
2 copper ion binding GO:0005507 8.62 ALB ATP7A

Sources for Copper Deficiency Myelopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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