Cork-Handlers' Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRK001 MIFTS: 29	Cork-Handlers' Disease Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Cork-Handlers' Disease

MalaCards integrated aliases for Cork-Handlers' Disease:

Name: Cork-Handlers' Disease ¹² ¹⁵

Suberosis ¹² ⁷¹ ³²

Cork-Handlers' Disease or Lung ¹²

Cork-Handlers' Lung ¹²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the respiratory system

Lung diseases due to external agents

Hypersensitivity pneumonitis due to organic dust

Suberosis

External Ids:

Disease Ontology ¹² DOID:840

ICD9CM ³⁴ 495.3

SNOMED-CT ⁶⁷ 13394002

ICD10 ³² J67.3

UMLS ⁷¹ C0152108

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Summaries for Cork-Handlers' Disease

Disease Ontology : ¹² An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia.

MalaCards based summary : Cork-Handlers' Disease, also known as suberosis, is related to lung disease and bronchitis. An important gene associated with Cork-Handlers' Disease is CD8A (CD8a Molecule), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include lung, t cells and skin, and related phenotype is endocrine/exocrine gland.

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Related Diseases for Cork-Handlers' Disease

Diseases related to Cork-Handlers' Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)

#	Related Disease	Score	Top Affiliating Genes
1	lung disease	29.6	CD8A CD40LG ALB
2	bronchitis	29.5	CD40LG ALB
3	extrinsic allergic alveolitis	11.0
4	pneumoconiosis	10.5
5	anthracosis	10.5
6	allergic hypersensitivity disease	10.3
7	interstitial lung disease	10.3
8	idiopathic interstitial pneumonia	10.1
9	pulmonary fibrosis	10.1
10	capillary disease	10.1	CD8A ALB
11	intestinal tuberculosis	10.1	CD4 ALB
12	capillary leak syndrome	10.1	CD8A ALB
13	bare lymphocyte syndrome, type i	10.1	CD8A CD4
14	ventilation pneumonitis	10.1	CD8A CD4
15	diffuse infiltrative lymphocytosis syndrome	10.1	CD8A CD4
16	autoimmune lymphoproliferative syndrome, type iia	10.1	CD8A CD4
17	chromosome 14q11-q22 deletion syndrome	10.1	CD8A CD4
18	diabetes mellitus, insulin-dependent, 23	10.1	CD8A CD4
19	bird fancier's lung	10.1	CD8A CD4
20	chronic graft versus host disease	10.1	CD4 ALB
21	parapsoriasis	10.1	CD8A CD4
22	metal allergy	10.1	CD8A CD4
23	variola major	10.1	CD8A CD4
24	follicular mucinosis	10.1	CD8A CD4
25	spongiotic dermatitis	10.1	CD8A CD4
26	nickel allergic contact dermatitis	10.1	CD8A CD4
27	combined thymoma	10.1	CD8A CD4
28	neurosarcoidosis	10.1	CD8A CD4
29	cd3zeta deficiency	10.1	CD8A CD4
30	immunodeficiency 18	10.1	CD8A CD4
31	acute interstitial pneumonia	10.1	CD8A CD4
32	anti-basement membrane glomerulonephritis	10.1	CD4 ALB
33	angular cheilitis	10.1	CD4 ALB
34	superficial basal cell carcinoma	10.1	CD8A CD4
35	oral tuberculosis	10.1	CD8A CD4
36	oral hairy leukoplakia	10.1	CD8A CD4
37	marasmus	10.1	CD4 ALB
38	farmer's lung	10.1	CD8A CD4
39	esophageal candidiasis	10.1	CD8A CD4
40	myeloid and lymphoid neoplasms associated with fgfr1 abnormalities	10.0	CD8A CD4
41	immunodeficiency 19	10.0	CD8A CD4
42	cardiomyopathy, familial hypertrophic, 9	10.0	CD8A CD4
43	pneumonic tularemia	10.0	CD8A CD4
44	laryngeal tuberculosis	10.0	CD8A CD4
45	pneumonic plague	10.0	CD8A CD4
46	autoimmune disease of cardiovascular system	10.0	CD8A CD4
47	kwashiorkor	10.0	CD4 ALB
48	cryptogenic organizing pneumonia	10.0	CD8A CD4
49	dacryoadenitis	10.0	CD8A CD4
50	mucocutaneous leishmaniasis	10.0	CD8A CD4

Graphical network of the top 20 diseases related to Cork-Handlers' Disease:

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Symptoms & Phenotypes for Cork-Handlers' Disease

MGI Mouse Phenotypes related to Cork-Handlers' Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	8.92	ALB CD4 CD40LG CD8A

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Drugs & Therapeutics for Cork-Handlers' Disease

Search Clinical Trials , NIH Clinical Center for Cork-Handlers' Disease

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Genetic Tests for Cork-Handlers' Disease

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Anatomical Context for Cork-Handlers' Disease

MalaCards organs/tissues related to Cork-Handlers' Disease:

⁴⁰

Lung, T Cells, Skin, B Cells, Eye, Bone, Thymus

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Publications for Cork-Handlers' Disease

Articles related to Cork-Handlers' Disease:

(show all 31)

#	Title	Authors	PMID	Year
1	Assessment of exposure to the Penicillium glabrum complex in cork industry using complementing methods. ⁶¹	Viegas C...Gomes AQ	26444341	2015
2	[Hypersensitivity pneumonitis caused by Mucor species in a cork worker]. ⁶¹	Villar A...Morell F	19376624	2009
3	Antigen characterization of major cork moulds in Suberosis (cork worker's pneumonitis) by immunoblotting. ⁶¹	Winck JC...Marques JA	15180761	2004
4	[Suberosis and bird fancier's disease: comparative study of radiological, functional and bronchoalveolar characteristics profile]. ⁶¹	Morais A...Marques A	15190428	2004
5	Suberosis and bird fancier's disease: a comparative study of radiological, functional and bronchoalveolar lavage profiles. ⁶¹	Morais A...Marques JA	15160439	2004
6	Respiratory diseases in French cork workers. ⁶¹	Deschamps F...Toubas D	14648360	2003
7	Suberosis: clinical study and new etiologic agents in a series of eight patients. ⁶¹	Morell F...Rodrigo MJ	12970049	2003
8	Broncho-alveolar inflammation in cork worker's asthma. ⁶¹	Winck JC...Sapage JM	12134642	2002
9	Monitoring of peak expiratory flow rates in cork workers' occupational asthma. ⁶¹	Winck JC...Sapage JM	11456389	2001
10	[Suberosis: involvement of bronchoalveolar +mastocytes in the genesis of interstitial involvement]. ⁶¹	Delgado L...Fleming Torrinha JA	10099726	1999
11	[Extrinsic allergic alveolitis caused by Penicillium frequentans. Review and presentation of a case]. ⁶¹	Moral AJ...Senent CJ	8000696	1994
12	Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia. ⁶¹	Alegre J...Cobo E	2166333	1990
13	[Suberosis: extrinsic allergic alveolitis in a cork worker]. ⁶¹	Ruiz Manzano J...Sendra SJ	6708649	1984
14	Some aspects of occupational asthma. ⁶¹	Avila R	6839446	1983
15	Epidemiologic aspects of suberosis and vineyard's sprayers lung. ⁶¹	Avila R	7427764	1980
16	[Diseases caused by inhalation of organic dusts]. ⁶¹	Palma-Carlos AG	1241651	1975
17	The role of Penicillium frequentans in suberosis (respiratory disease in workers in the cork industry). ⁶¹	Avila R...Lacey J	4842936	1974
18	[Suberosis. Epidemiologic study in a factory of cork products]. ⁶¹	Villar TG	4802814	1973
19	Respiratory disease in cork workers ("suberosis"). ⁶¹	Pimentel JC...Avila R	4200382	1973
20	Some aspects of suberosis: respiratory disease in cork workers. ⁶¹	Avila R	4265665	1972
21	[On pneumoconiosis caused by cork (suberosis)]. ⁶¹	Lo Storto A...De Salvia F	5142905	1971
22	Suberosis. Respiratory disease in cork workers. ⁶¹	Avila R...Villar TG	4170905	1968
23	SUBEROSIS: A PNEUMOCONIOSIS DUE TO CORK DUST--THE PRESENT STAGE OF THE PROBLEM. ⁶¹	DE CARVALHO CANCELLA L	14068914	1963
24	[Contribution to information on cork dust pneumoconiosis (suberosis) in man]. ⁶¹	REMMELE W...EINBRODT HJ	14491411	1962
25	[Suberosis]. ⁶¹	de ABREU L	13859089	1961
26	[Contribution to the problem of cork dust lung disease (suberosis) in man]. ⁶¹	REMMELE W	14491412	1961
27	[Angiopneumography in suberosis]. ⁶¹	de CANCELLA LC	13690365	1960
28	[Experimental pneumoconiosis due to cork; experimental suberosis]. ⁶¹	DA HORTA JS...DE CANCELLA LC	13435742	1957
29	[Experimental suberosis]. ⁶¹	DA HORTA JS...DE CANCELLA LC	13386652	1956
30	[Experimental coniosis caused by cork dust; experimental suberosis]. ⁶¹	DA HORTA JS...DE CANCELLA LC	13366548	1956
31	On a special kind of pneumoconiosis: the suberosis; preliminary report. ⁶¹	CANCELLA Lde C	14393279	1955

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Genes for Cork-Handlers' Disease

Genes related to Cork-Handlers' Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD8A	CD8a Molecule	Protein Coding	4.96	DISEASES inferred ¹⁵
2	CD4	CD4 Molecule	Protein Coding	4.76	DISEASES inferred ¹⁵
3	CD40LG	CD40 Ligand	Protein Coding	4.08	DISEASES inferred ¹⁵
4	ALB	Albumin	Protein Coding	3.64	DISEASES inferred ¹⁵

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Variations for Cork-Handlers' Disease

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Expression for Cork-Handlers' Disease

Search GEO for disease gene expression data for Cork-Handlers' Disease.

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Pathways for Cork-Handlers' Disease

Pathways related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.24	CD8A CD40LG CD4
2	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	11.87	CD8A CD40LG CD4
3	Hematopoietic cell lineage ³⁶	11.45	CD8A CD4
4	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.34	CD8A CD4
5	Cell adhesion molecules (CAMs) ³⁶	11.3	CD8A CD40LG CD4
6	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.27	CD8A CD4
7	CTLA4 Signaling ⁶³	11.22	CD8A CD4
8	B Cell Development Pathways ⁶⁴	10.98	CD40LG CD4
9	Primary immunodeficiency ³⁶	10.38	CD8A CD40LG CD4

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GO Terms for Cork-Handlers' Disease

Cellular components related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.8	CD8A CD40LG CD4

Biological processes related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of T cell proliferation	GO:0042102	9.16	CD40LG CD4
2	immune response	GO:0006955	9.13	CD8A CD40LG CD4
3	T cell activation	GO:0042110	8.62	CD8A CD4

Molecular functions related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	8.62	CD8A CD4

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Sources for Cork-Handlers' Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia