MCID: CRK001
MIFTS: 29

Cork-Handlers' Disease

Categories: Respiratory diseases

Aliases & Classifications for Cork-Handlers' Disease

MalaCards integrated aliases for Cork-Handlers' Disease:

Name: Cork-Handlers' Disease 12 15
Suberosis 12 71 32
Cork-Handlers' Disease or Lung 12
Cork-Handlers' Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:840
ICD9CM 34 495.3
SNOMED-CT 67 13394002
ICD10 32 J67.3
UMLS 71 C0152108

Summaries for Cork-Handlers' Disease

Disease Ontology : 12 An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia.

MalaCards based summary : Cork-Handlers' Disease, also known as suberosis, is related to lung disease and bronchitis. An important gene associated with Cork-Handlers' Disease is CD8A (CD8a Molecule), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include lung, t cells and skin, and related phenotype is endocrine/exocrine gland.

Related Diseases for Cork-Handlers' Disease

Diseases related to Cork-Handlers' Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)
# Related Disease Score Top Affiliating Genes
1 lung disease 29.6 CD8A CD40LG ALB
2 bronchitis 29.5 CD40LG ALB
3 extrinsic allergic alveolitis 11.0
4 pneumoconiosis 10.5
5 anthracosis 10.5
6 allergic hypersensitivity disease 10.3
7 interstitial lung disease 10.3
8 idiopathic interstitial pneumonia 10.1
9 pulmonary fibrosis 10.1
10 capillary disease 10.1 CD8A ALB
11 intestinal tuberculosis 10.1 CD4 ALB
12 capillary leak syndrome 10.1 CD8A ALB
13 bare lymphocyte syndrome, type i 10.1 CD8A CD4
14 ventilation pneumonitis 10.1 CD8A CD4
15 diffuse infiltrative lymphocytosis syndrome 10.1 CD8A CD4
16 autoimmune lymphoproliferative syndrome, type iia 10.1 CD8A CD4
17 chromosome 14q11-q22 deletion syndrome 10.1 CD8A CD4
18 diabetes mellitus, insulin-dependent, 23 10.1 CD8A CD4
19 bird fancier's lung 10.1 CD8A CD4
20 chronic graft versus host disease 10.1 CD4 ALB
21 parapsoriasis 10.1 CD8A CD4
22 metal allergy 10.1 CD8A CD4
23 variola major 10.1 CD8A CD4
24 follicular mucinosis 10.1 CD8A CD4
25 spongiotic dermatitis 10.1 CD8A CD4
26 nickel allergic contact dermatitis 10.1 CD8A CD4
27 combined thymoma 10.1 CD8A CD4
28 neurosarcoidosis 10.1 CD8A CD4
29 cd3zeta deficiency 10.1 CD8A CD4
30 immunodeficiency 18 10.1 CD8A CD4
31 acute interstitial pneumonia 10.1 CD8A CD4
32 anti-basement membrane glomerulonephritis 10.1 CD4 ALB
33 angular cheilitis 10.1 CD4 ALB
34 superficial basal cell carcinoma 10.1 CD8A CD4
35 oral tuberculosis 10.1 CD8A CD4
36 oral hairy leukoplakia 10.1 CD8A CD4
37 marasmus 10.1 CD4 ALB
38 farmer's lung 10.1 CD8A CD4
39 esophageal candidiasis 10.1 CD8A CD4
40 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.0 CD8A CD4
41 immunodeficiency 19 10.0 CD8A CD4
42 cardiomyopathy, familial hypertrophic, 9 10.0 CD8A CD4
43 pneumonic tularemia 10.0 CD8A CD4
44 laryngeal tuberculosis 10.0 CD8A CD4
45 pneumonic plague 10.0 CD8A CD4
46 autoimmune disease of cardiovascular system 10.0 CD8A CD4
47 kwashiorkor 10.0 CD4 ALB
48 cryptogenic organizing pneumonia 10.0 CD8A CD4
49 dacryoadenitis 10.0 CD8A CD4
50 mucocutaneous leishmaniasis 10.0 CD8A CD4

Graphical network of the top 20 diseases related to Cork-Handlers' Disease:



Diseases related to Cork-Handlers' Disease

Symptoms & Phenotypes for Cork-Handlers' Disease

MGI Mouse Phenotypes related to Cork-Handlers' Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.92 ALB CD4 CD40LG CD8A

Drugs & Therapeutics for Cork-Handlers' Disease

Search Clinical Trials , NIH Clinical Center for Cork-Handlers' Disease

Genetic Tests for Cork-Handlers' Disease

Anatomical Context for Cork-Handlers' Disease

MalaCards organs/tissues related to Cork-Handlers' Disease:

40
Lung, T Cells, Skin, B Cells, Eye, Bone, Thymus

Publications for Cork-Handlers' Disease

Articles related to Cork-Handlers' Disease:

(show all 31)
# Title Authors PMID Year
1
Assessment of exposure to the Penicillium glabrum complex in cork industry using complementing methods. 61
26444341 2015
2
[Hypersensitivity pneumonitis caused by Mucor species in a cork worker]. 61
19376624 2009
3
Antigen characterization of major cork moulds in Suberosis (cork worker's pneumonitis) by immunoblotting. 61
15180761 2004
4
[Suberosis and bird fancier's disease: comparative study of radiological, functional and bronchoalveolar characteristics profile]. 61
15190428 2004
5
Suberosis and bird fancier's disease: a comparative study of radiological, functional and bronchoalveolar lavage profiles. 61
15160439 2004
6
Respiratory diseases in French cork workers. 61
14648360 2003
7
Suberosis: clinical study and new etiologic agents in a series of eight patients. 61
12970049 2003
8
Broncho-alveolar inflammation in cork worker's asthma. 61
12134642 2002
9
Monitoring of peak expiratory flow rates in cork workers' occupational asthma. 61
11456389 2001
10
[Suberosis: involvement of bronchoalveolar +mastocytes in the genesis of interstitial involvement]. 61
10099726 1999
11
[Extrinsic allergic alveolitis caused by Penicillium frequentans. Review and presentation of a case]. 61
8000696 1994
12
Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia. 61
2166333 1990
13
[Suberosis: extrinsic allergic alveolitis in a cork worker]. 61
6708649 1984
14
Some aspects of occupational asthma. 61
6839446 1983
15
Epidemiologic aspects of suberosis and vineyard's sprayers lung. 61
7427764 1980
16
[Diseases caused by inhalation of organic dusts]. 61
1241651 1975
17
The role of Penicillium frequentans in suberosis (respiratory disease in workers in the cork industry). 61
4842936 1974
18
[Suberosis. Epidemiologic study in a factory of cork products]. 61
4802814 1973
19
Respiratory disease in cork workers ("suberosis"). 61
4200382 1973
20
Some aspects of suberosis: respiratory disease in cork workers. 61
4265665 1972
21
[On pneumoconiosis caused by cork (suberosis)]. 61
5142905 1971
22
Suberosis. Respiratory disease in cork workers. 61
4170905 1968
23
SUBEROSIS: A PNEUMOCONIOSIS DUE TO CORK DUST--THE PRESENT STAGE OF THE PROBLEM. 61
14068914 1963
24
[Contribution to information on cork dust pneumoconiosis (suberosis) in man]. 61
14491411 1962
25
[Suberosis]. 61
13859089 1961
26
[Contribution to the problem of cork dust lung disease (suberosis) in man]. 61
14491412 1961
27
[Angiopneumography in suberosis]. 61
13690365 1960
28
[Experimental pneumoconiosis due to cork; experimental suberosis]. 61
13435742 1957
29
[Experimental suberosis]. 61
13386652 1956
30
[Experimental coniosis caused by cork dust; experimental suberosis]. 61
13366548 1956
31
On a special kind of pneumoconiosis: the suberosis; preliminary report. 61
14393279 1955

Variations for Cork-Handlers' Disease

Expression for Cork-Handlers' Disease

Search GEO for disease gene expression data for Cork-Handlers' Disease.

Pathways for Cork-Handlers' Disease

GO Terms for Cork-Handlers' Disease

Cellular components related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD8A CD40LG CD4

Biological processes related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.16 CD40LG CD4
2 immune response GO:0006955 9.13 CD8A CD40LG CD4
3 T cell activation GO:0042110 8.62 CD8A CD4

Molecular functions related to Cork-Handlers' Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Cork-Handlers' Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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