MCID: CRN022
MIFTS: 26

Corneal Degeneration

Categories: Eye diseases

Aliases & Classifications for Corneal Degeneration

MalaCards integrated aliases for Corneal Degeneration:

Name: Corneal Degeneration 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1237
ICD9CM 36 371.4 371.40
ICD10 34 H18.4 H18.40
UMLS 74 C0155118

Summaries for Corneal Degeneration

MalaCards based summary : Corneal Degeneration is related to corneal dystrophy, gelatinous drop-like and corneal dystrophy. An important gene associated with Corneal Degeneration is MBTPS2 (Membrane Bound Transcription Factor Peptidase, Site 2). The drugs Lansoprazole and Dexlansoprazole have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Corneal Degeneration

Graphical network of the top 20 diseases related to Corneal Degeneration:



Diseases related to Corneal Degeneration

Symptoms & Phenotypes for Corneal Degeneration

GenomeRNAi Phenotypes related to Corneal Degeneration according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.32 COG2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.32 COG2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.32 COG2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.32 KRT12
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.32 KRT12
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.32 KRT12
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.32 COG2 KRT12
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.32 KRT12
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.32 COG2

Drugs & Therapeutics for Corneal Degeneration

Drugs for Corneal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
2
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
3 Proton Pump Inhibitors Phase 4
4 Antacids Phase 4
5 Anti-Ulcer Agents Phase 4
6 Gastrointestinal Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Lansoprazole in Patients With Reflux Disease Completed NCT01135368 Phase 4 Lansoprazole
2 Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders Unknown status NCT02444923 Not Applicable
3 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea Recruiting NCT03220529 Not Applicable

Search NIH Clinical Center for Corneal Degeneration

Genetic Tests for Corneal Degeneration

Anatomical Context for Corneal Degeneration

MalaCards organs/tissues related to Corneal Degeneration:

42
Eye, Testes, Endothelial

Publications for Corneal Degeneration

Articles related to Corneal Degeneration:

(show top 50) (show all 103)
# Title Authors Year
1
Corneal Stromal transplantation with Human-Derived Acellular Dermal Matrix for Pellucid Marginal Corneal Degeneration: A Nonrandomized Clinical Trial. ( 30801540 )
2019
2
Deep blue dot corneal degeneration: confocal characteristics. ( 29423782 )
2019
3
Lipoidal corneal degeneration in aged falcons. ( 29350449 )
2018
4
Acute hydrops with a 180-degree massive edematous cavern demonstrated by three dimensional view of anterior segment optical coherence tomography in a patient with pellucid marginal corneal degeneration, a case report. ( 29653558 )
2018
5
Corneal hysteresis and corneal resistance factor in pellucid marginal corneal degeneration. ( 29988910 )
2018
6
Crescentic Tuck in Lamellar Keratoplasty-A Novel Technique in a Case of Advanced Pellucid Marginal Corneal Degeneration. ( 30160655 )
2018
7
Stromal corneal dystrophy (possible Schnyder's dystrophy) with peripheral corneal degeneration - diagnostic and therapeutic challenges. ( 30206563 )
2018
8
Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses. ( 26773714 )
2017
9
An Unusual Corneal Degeneration. ( 28334307 )
2017
10
Peripheral Hypertrophic Subepithelial Corneal Degeneration. ( 28594994 )
2017
11
National survey of pellucid marginal corneal degeneration in Japan. ( 27401170 )
2016
12
Peripheral hypertrophic subepithelial corneal degeneration presenting with bilateral nasal and temporal corneal changes. ( 25277306 )
2015
13
Comparison of Scheimpflug imaging analysis of pellucid marginal corneal degeneration and keratoconus. ( 25504087 )
2015
14
Re: peripheral hypertrophic subepithelial corneal degeneration - clinical and histopathological features. ( 25809296 )
2015
15
Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. ( 26024086 )
2015
16
Peripheral hypertrophic subepithelial corneal degeneration: characterization, treatment and association with human leucocyte antigen genes. ( 23388055 )
2014
17
Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration. ( 24292162 )
2014
18
Re: Gore et al.: Peripheral hypertrophic subepithelial corneal degeneration: nomenclature, phenotypes, and long-term outcomes (Ophthalmology 2013;120:892-8). ( 24484990 )
2014
19
Peripheral hypertrophic subepithelial corneal degeneration - clinical and histopathological features. ( 24655442 )
2014
20
Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration. ( 24702579 )
2014
21
Spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops. ( 23407319 )
2013
22
Peripheral hypertrophic subepithelial corneal degeneration: nomenclature, phenotypes, and long-term outcomes. ( 23474249 )
2013
23
Combined tissue excision and corneal tuck for the surgical treatment of extremely advanced pellucid marginal corneal degeneration. ( 24162753 )
2013
24
Myxomatous corneal degeneration: a clinicopathological study of six cases and a review of the literature. ( 22370508 )
2012
25
Ring-shaped corneoscleral lamellar keratoplasty guided by high-definition optical coherence tomography and Scheimpflug imaging for severe Terrien's marginal corneal degeneration. ( 22573412 )
2012
26
Familial pattern of Salzmann-type nodular corneal degeneration – a four generation series. Reply to Papanikolaou et al. ( 21169267 )
2011
27
In vivo confocal microscopy in Terrien marginal corneal degeneration: a case report. ( 21282992 )
2011
28
Corneal changes after suspending contact lens wear in early pellucid marginal corneal degeneration and moderate keratoconus. ( 21336035 )
2011
29
Salzmann's nodular corneal degeneration (SNCD): clinical findings, risk factors, prognosis and the role of previous contact lens wear. ( 21349758 )
2011
30
A single 210-degree arc length intrastromal corneal ring implantation for the management of pellucid marginal corneal degeneration. ( 20570241 )
2010
31
Familial pattern of Salzmann-type nodular corneal degeneration--a four generation series. ( 20679082 )
2010
32
Bilateral Salzmann-like nodular corneal degeneration after laser in situ keratomileusis imaged with anterior segment optical coherence tomography and high-frequency ultrasound biomicroscopy. ( 19304107 )
2009
33
Management of pellucid marginal corneal degeneration with simultaneous customized photorefractive keratectomy and collagen crosslinking. ( 19545822 )
2009
34
Histopathology of Salzmann nodular corneal degeneration. ( 18216567 )
2008
35
Intracameral SF6 injection and anterior segment OCT-based documentation for acute hydrops management in pellucid marginal corneal degeneration. ( 18291707 )
2008
36
Combined wedge resection and beveled penetrating relaxing incisions for the treatment of pellucid marginal corneal degeneration. ( 18520511 )
2008
37
Characteristics of ocular higher-order aberrations in patients with pellucid marginal corneal degeneration. ( 19006740 )
2008
38
Ultraviolet radiation-induced corneal degeneration in 129 mice. ( 17943656 )
2007
39
Reduction of hyperopia and astigmatism after superficial keratectomy of peripheral hypertrophic subepithelial corneal degeneration. ( 16702871 )
2006
40
Recurrent corneal perforation and acute calcareous corneal degeneration in chronic graft-versus-host disease. ( 16618614 )
2006
41
Salzmann's nodular corneal degeneration clinical characteristics and surgical outcomes. ( 16331034 )
2006
42
Pellucid marginal corneal degeneration: evaluation of the corneal surface and contact lens fitting. ( 16488954 )
2006
43
Intrastromal ring segment insertion using a femtosecond laser to correct pellucid marginal corneal degeneration. ( 17010872 )
2006
44
Compressive C-shaped lamellar keratoplasty: a surgical alternative for the management of severe astigmatism from peripheral corneal degeneration. ( 15745769 )
2005
45
Management of pellucid marginal corneal degeneration. ( 15968160 )
2005
46
Bitoric gas-permeable contact lens application in pellucid marginal corneal degeneration. ( 16163019 )
2005
47
Implantation of a toric phakic intraocular lens to correct high corneal astigmatism in a patient with bilateral marginal corneal degeneration. ( 15030849 )
2004
48
Superior pellucid marginal corneal degeneration. ( 15069437 )
2004
49
Lamellar crescentic resection for pellucid marginal corneal degeneration. ( 15072316 )
2004
50
Pellucid marginal corneal degeneration. ( 15177959 )
2004

Variations for Corneal Degeneration

Expression for Corneal Degeneration

Search GEO for disease gene expression data for Corneal Degeneration.

Pathways for Corneal Degeneration

GO Terms for Corneal Degeneration

Sources for Corneal Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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