MCID: CRN022
MIFTS: 33

Corneal Degeneration

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Corneal Degeneration

MalaCards integrated aliases for Corneal Degeneration:

Name: Corneal Degeneration 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1237
ICD9CM 34 371.4
SNOMED-CT 67 111521006
ICD10 32 H18.4
UMLS 70 C0155118

Summaries for Corneal Degeneration

MalaCards based summary : Corneal Degeneration is related to astigmatism and stromal corneal dystrophy. An important gene associated with Corneal Degeneration is SLC4A4 (Solute Carrier Family 4 Member 4), and among its related pathways/superpathways are Lipoprotein metabolism and Statin Pathway. Affiliated tissues include eye, endothelial and bone marrow, and related phenotype is vision/eye.

Related Diseases for Corneal Degeneration

Diseases related to Corneal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 astigmatism 30.7 VSX1 KRT3 KRT12 KERA
2 stromal corneal dystrophy 30.1 UBIAD1 TGFBI
3 pseudopterygium 29.9 SLC4A11 KRT3 KRT12
4 corneal ectasia 29.8 VSX1 TGFBI KRT3 KERA COL8A2
5 epithelial basement membrane dystrophy 29.8 TGFBI KRT3 CHST6
6 keratoconus 29.8 VSX1 TGFBI SLC4A11 KRT3 KRT12 KERA
7 lattice corneal dystrophy 29.6 TGFBI KRT3 KRT12 CHST6
8 irregular astigmatism 29.6 VSX1 TGFBI SLC4A11 KRT3 KRT12 KERA
9 corneal edema 29.5 VSX1 TGFBI SLC4A11 KRT3 KERA COL8A2
10 corneal dystrophy, band-shaped 29.5 SLC9A8 SLC9A3 SLC4A7 SLC4A4 SLC4A11
11 corneal dystrophy, gelatinous drop-like 29.2 UBIAD1 TGFBI KRT3 KRT12 COL8A2 CHST6
12 corneal disease 28.7 VSX1 UBIAD1 TGFBI SLC4A11 KRT3 KRT12
13 corneal dystrophy 28.0 VSX1 UBIAD1 TGFBI SLC4A11 KRT3 KRT12
14 corneal degeneration, ribbonlike, with deafness 11.1
15 corneal degeneration, band-shaped spheroid 11.1
16 keratosis follicularis spinulosa decalvans, x-linked 10.9
17 multicentric castleman disease 10.5
18 defective apolipoprotein b-100 10.3 PCSK9 APOB
19 hypobetalipoproteinemia, familial, 2 10.2 PCSK9 APOB
20 keratopathy 10.2
21 secondary corneal edema 10.2 SLC4A11 COL8A2
22 interstitial keratitis 10.2 TGFBI COL8A2
23 pellucid marginal degeneration 10.2
24 limbal stem cell deficiency 10.2 KRT3 KRT12
25 osgood-schlatter's disease 10.2 VSX1 COL8A2
26 hypercholesterolemia, familial, 4 10.2 PCSK9 LDLRAP1 APOB
27 cataract 10.1
28 keratoconjunctivitis 10.1
29 corneal dystrophy, endothelial, x-linked 10.1 VSX1 SLC4A11 COL8A2
30 osteopetrosis, autosomal recessive 4 10.1 TGFBI SLC4A4
31 corneal dystrophy, posterior polymorphous, 2 10.1 VSX1 SLC4A11 COL8A2
32 keratitis, hereditary 10.1
33 silent myocardial infarction 10.1 APOB APOA1
34 leukodystrophy, hypomyelinating, 3 10.1 APOB APOA1
35 schnyder corneal dystrophy 10.0 UBIAD1 TGFBI KRT3 KRT12
36 trachoma 10.0
37 keratoconjunctivitis sicca 10.0
38 fetal macrosomia 10.0 APOB APOA1
39 familial lipoprotein lipase deficiency 10.0 APOB APOA1
40 corneal dystrophy, groenouw type i 10.0 UBIAD1 TGFBI KRT12 CHST6
41 parametritis 10.0 APOB APOA1
42 hypolipoproteinemia 10.0 PCSK9 APOB APOA1
43 intestinal impaction 10.0 SLC9A3 SLC4A7 SLC4A4
44 coronary heart disease 1 10.0 PCSK9 APOB APOA1
45 intermediate coronary syndrome 10.0 PCSK9 APOB APOA1
46 corneal dystrophy, avellino type 10.0 TGFBI KRT3 KRT12 CHST6
47 familial apolipoprotein c-ii deficiency 10.0 APOB APOA1
48 hypobetalipoproteinemia, familial, 1 10.0 PCSK9 APOB APOA1
49 hyperlipoproteinemia, type i 10.0 PCSK9 APOB APOA1
50 abetalipoproteinemia 10.0 PCSK9 APOB APOA1

Comorbidity relations with Corneal Degeneration via Phenotypic Disease Network (PDN):


Bullous Keratopathy

Graphical network of the top 20 diseases related to Corneal Degeneration:



Diseases related to Corneal Degeneration

Symptoms & Phenotypes for Corneal Degeneration

MGI Mouse Phenotypes related to Corneal Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.44 APOB CHST6 COL8A2 ERCC6 KERA KRT12

Drugs & Therapeutics for Corneal Degeneration

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea Unknown status NCT03220529

Search NIH Clinical Center for Corneal Degeneration

Genetic Tests for Corneal Degeneration

Anatomical Context for Corneal Degeneration

MalaCards organs/tissues related to Corneal Degeneration:

40
Eye, Endothelial, Bone Marrow, Bone, Heart

Publications for Corneal Degeneration

Articles related to Corneal Degeneration:

(show top 50) (show all 276)
# Title Authors PMID Year
1
Tuck In Femtosecond Laser Assisted Anterior Lamellar Keratoplasty (T-FALK) for the Management of Superficial Anterior Corneal Scars-A Modified Technique. 61
32947401 2021
2
Corneal neovascularization. 61
33221371 2021
3
Salzmann's nodular degeneration. 61
33212141 2021
4
Long-term outcome of custom toric intraocular lens for treating high astigmatism in case of cataract associated with pellucid marginal corneal degeneration. 61
33245061 2020
5
Treating Mooren's Ulcer - Squeezing Water From a Stone. 61
33505815 2020
6
Excimer laser-assisted phototherapeutic keratectomies combined to EDTA chelation for the treatment of calcific band keratopathy. 61
33153293 2020
7
Bioengineering Approaches for Corneal Regenerative Medicine. 61
32696417 2020
8
Kahook Dual Blade goniotomy in post penetrating keratoplasty steroid-induced ocular hypertension. 61
32685769 2020
9
[Corneal alterations in eyelid diseases]. 61
32870336 2020
10
Keratoconus prognosis study for patients with corneal external mechanical stress mode. 61
32219616 2020
11
Successful surgical management of post-penetrating or deep lamellar keratoplasty Acquired Corneal Sub-Epithelial Hypertrophy (ACSH): A case series. 61
32062505 2020
12
[Results of surgical treatment of complicated uveal cataract]. 61
33063966 2020
13
Optical coherence elastography by ambient pressure modulation for high-resolution strain mapping applied to patterned cross-linking. 61
31964268 2020
14
Assessment of low-vault cases with an implantable collamer lens. 61
33147267 2020
15
Secondary Corneal Myxoma After DMEK (Descemet Membrane Endothelial Keratoplasty). 61
31511491 2019
16
Band keratopathy in children previously treated with diode laser for type 1 retinopathy of prematurity. 61
31153950 2019
17
Successful Treatment of Corneal Opacification with Associated Thickened Epithelium by Simple Peeling: Acquired Corneal Subepithelial Hypertrophy (ACSH). 61
31686959 2019
18
[Muraine sutures accelerate healing of corneal hydrops in acute keratotorus]. 61
30229285 2019
19
Corneal Stromal Transplantation With Human-derived Acellular Dermal Matrix for Pellucid Marginal Corneal Degeneration: A Nonrandomized Clinical Trial. 61
30801540 2019
20
Deep blue dot corneal degeneration: confocal characteristics. 61
29423782 2019
21
In Vivo Confocal Microscopy of Cornea in Patients with Terrien's Marginal Corneal Degeneration. 61
31380111 2019
22
Peripheral hypertrophic subepithelial corneal degeneration: clinical aspects related to in vivo confocal microscopy and optical coherence tomography. 61
31440105 2019
23
[Features of the course of anterior uveitis associated with HLA-B27 antigen]. 61
31691649 2019
24
[Terrien's marginal corneal degeneration in a six-year-old girl: A case report]. 61
30391186 2018
25
Crescentic Tuck in Lamellar Keratoplasty-A Novel Technique in a Case of Advanced Pellucid Marginal Corneal Degeneration. 61
30160655 2018
26
Efficacy and safety of amantadine for the treatment of L-DOPA-induced dyskinesia. 61
29511826 2018
27
Lipoidal corneal degeneration in aged falcons. 61
29350449 2018
28
Corneal hysteresis and corneal resistance factor in pellucid marginal corneal degeneration. 61
29988910 2018
29
Stromal corneal dystrophy (possible Schnyder's dystrophy) with peripheral corneal degeneration - diagnostic and therapeutic challenges. 61
30206563 2018
30
Acute hydrops with a 180-degree massive edematous cavern demonstrated by three dimensional view of anterior segment optical coherence tomography in a patient with pellucid marginal corneal degeneration, a case report. 61
29653558 2018
31
[Bandage keratoplasty therapeutic-optical in treatment of progressing pellucid marginal corneal degeneration (a preliminary report)]. 61
30499514 2018
32
Spontaneous corneal perforation in Terrien's marginal degeneration in childhood: A case report. 61
29245335 2017
33
Analysis of long-term visual quality with numerical 3D ray tracing after corneal crosslinking treatment. 61
29240126 2017
34
Combined Cataract/DSEK/DMEK: Changing Expectations. 61
28726355 2017
35
[Acute spontaneous corneal hydrops in a patient with pellucid marginal corneal degeneration]. 61
28579380 2017
36
An Unusual Corneal Degeneration. 61
28334307 2017
37
Peripheral Hypertrophic Subepithelial Corneal Degeneration. 61
28594994 2017
38
[Results of corneal crosslinking for pellucid marginal corneal degeneration]. 61
28745658 2017
39
Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses. 61
26773714 2017
40
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma. 61
28300746 2017
41
[Peripheral hypertrophic subepithelial corneal degeneration visualized by in vivo confocal microscopy]. 61
27843083 2016
42
National survey of pellucid marginal corneal degeneration in Japan. 61
27401170 2016
43
Personalized Stem Cell Therapy to Correct Corneal Defects Due to a Unique Homozygous-Heterozygous Mosaicism of Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome. 61
27151912 2016
44
Amniotic membrane transplantation: Current indications in a tertiary eye hospital of eastern Nepal. 61
28478469 2016
45
Post-Mortem Corneal Thickness Measurements with a Portable Optical Coherence Tomography System: a Reliability Study. 61
27457021 2016
46
Contact-mediated control of radial migration of corneal epithelial cells. 61
27563231 2016
47
The use of intracorneal ring segments in keratoconus. 61
26981548 2016
48
Degeneration and Regeneration of Subbasal Corneal Nerves after Infectious Keratitis: A Longitudinal In Vivo Confocal Microscopy Study. 61
26256833 2015
49
Re: peripheral hypertrophic subepithelial corneal degeneration - clinical and histopathological features. 61
25809296 2015
50
Staging of development in Terrien's degeneration based on corneal curvatures detected by optical coherence tomography. 61
25994951 2015

Variations for Corneal Degeneration

Expression for Corneal Degeneration

Search GEO for disease gene expression data for Corneal Degeneration.

Pathways for Corneal Degeneration

GO Terms for Corneal Degeneration

Cellular components related to Corneal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.71 PCSK9 LDLRAP1 APOB APOA1
2 extracellular matrix GO:0031012 9.62 TGFBI KERA COL8A2 COL17A1
3 very-low-density lipoprotein particle GO:0034361 9.46 APOB APOA1
4 endocytic vesicle lumen GO:0071682 9.43 APOB APOA1
5 low-density lipoprotein particle GO:0034362 9.37 APOB APOA1
6 basement membrane GO:0005604 9.33 TGFBI COL8A2 COL17A1
7 chylomicron GO:0042627 9.26 APOB APOA1
8 endoplasmic reticulum lumen GO:0005788 9.02 PCSK9 COL8A2 COL17A1 APOB APOA1
9 intermediate-density lipoprotein particle GO:0034363 8.96 APOB APOA1

Biological processes related to Corneal Degeneration according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.02 SLC9A8 SLC9A3 SLC4A7 SLC4A4 SLC4A11
2 transmembrane transport GO:0055085 10.02 SLC9A8 SLC9A3 SLC4A7 SLC4A4 SLC4A11 APOA1
3 lipid metabolic process GO:0006629 10 PCSK9 MBTPS2 LDLRAP1 APOB APOA1
4 cellular protein metabolic process GO:0044267 9.88 TGFBI PCSK9 APOB APOA1
5 visual perception GO:0007601 9.87 VSX1 TGFBI KRT12 KERA
6 cholesterol homeostasis GO:0042632 9.8 PCSK9 LDLRAP1 APOB APOA1
7 proton transmembrane transport GO:1902600 9.79 SLC9A8 SLC9A3 SLC4A11
8 sodium ion transport GO:0006814 9.77 SLC9A8 SLC9A3 SLC4A7 SLC4A4 SLC4A11
9 steroid metabolic process GO:0008202 9.72 PCSK9 MBTPS2 LDLRAP1 APOB APOA1
10 bicarbonate transport GO:0015701 9.71 SLC4A7 SLC4A4 SLC4A11
11 anion transport GO:0006820 9.7 SLC4A7 SLC4A4 SLC4A11
12 inorganic anion transport GO:0015698 9.69 SLC4A7 SLC4A4 SLC4A11
13 lipoprotein metabolic process GO:0042157 9.65 PCSK9 APOB APOA1
14 sodium ion transmembrane transport GO:0035725 9.65 SLC9A8 SLC9A3 SLC4A7 SLC4A4 SLC4A11
15 low-density lipoprotein particle clearance GO:0034383 9.63 PCSK9 LDLRAP1 APOB
16 regulation of pH GO:0006885 9.61 SLC9A8 SLC9A3
17 cholesterol transport GO:0030301 9.61 LDLRAP1 APOB APOA1
18 chylomicron assembly GO:0034378 9.6 APOB APOA1
19 cornea development in camera-type eye GO:0061303 9.59 KRT12 KERA
20 chylomicron remodeling GO:0034371 9.58 APOB APOA1
21 ion homeostasis GO:0050801 9.58 SLC4A7 SLC4A4 SLC4A11
22 lipoprotein biosynthetic process GO:0042158 9.56 APOB APOA1
23 cholesterol metabolic process GO:0008203 9.55 PCSK9 MBTPS2 LDLRAP1 APOB APOA1
24 regulation of intracellular pH GO:0051453 9.26 SLC9A8 SLC9A3 SLC4A7 SLC4A4
25 anion transmembrane transport GO:0098656 9.02 SLC9A8 SLC9A3 SLC4A7 SLC4A4 SLC4A11

Molecular functions related to Corneal Degeneration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.67 TGFBI COL8A2 COL17A1
2 symporter activity GO:0015293 9.63 SLC4A7 SLC4A4 SLC4A11
3 intermembrane cholesterol transfer activity GO:0120020 9.48 APOB APOA1
4 solute:proton antiporter activity GO:0015299 9.43 SLC9A8 SLC9A3
5 anion transmembrane transporter activity GO:0008509 9.4 SLC4A7 SLC4A4
6 sodium:proton antiporter activity GO:0015385 9.37 SLC9A8 SLC9A3
7 potassium:proton antiporter activity GO:0015386 9.32 SLC9A8 SLC9A3
8 sodium:bicarbonate symporter activity GO:0008510 9.26 SLC4A7 SLC4A4
9 apolipoprotein receptor binding GO:0034190 9.16 PCSK9 APOA1
10 low-density lipoprotein particle receptor binding GO:0050750 9.13 PCSK9 LDLRAP1 APOB
11 inorganic anion exchanger activity GO:0005452 8.8 SLC4A7 SLC4A4 SLC4A11

Sources for Corneal Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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