MCID: CRN022
MIFTS: 27

Corneal Degeneration

Categories: Eye diseases

Aliases & Classifications for Corneal Degeneration

MalaCards integrated aliases for Corneal Degeneration:

Name: Corneal Degeneration 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1237
ICD10 33 H18.4 H18.40
ICD9CM 35 371.4 371.40
UMLS 73 C0155118

Summaries for Corneal Degeneration

MalaCards based summary : Corneal Degeneration is related to keratosis follicularis spinulosa decalvans, x-linked and keratoconus. An important gene associated with Corneal Degeneration is SAT1 (Spermidine/Spermine N1-Acetyltransferase 1). The drugs Dexlansoprazole and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotype is vision/eye.

Related Diseases for Corneal Degeneration

Diseases related to Corneal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 keratosis follicularis spinulosa decalvans, x-linked 31.7 MBTPS2 SAT1
2 keratoconus 29.8 KRT12 TGFBI VSX1
3 corneal dystrophy 29.8 KRT12 TGFBI VSX1
4 corneal dystrophy, band-shaped 29.7 SLC4A4 VSX1
5 corneal dystrophy, gelatinous drop-like 29.6 KRT12 TGFBI
6 corneal degeneration, ribbonlike, with deafness 12.1
7 corneal degeneration, band-shaped spheroid 12.1
8 keratosis 10.2 MBTPS2 SAT1
9 keratosis follicularis spinulosa decalvans 10.2 MBTPS2 SAT1
10 blepharitis 10.1 MBTPS2 SAT1
11 hair disease 10.1 MBTPS2 SAT1
12 recurrent corneal erosion 10.1 DNAJC9 TGFBI
13 corneal granular dystrophy 10.0 KRT12 TGFBI
14 epithelial and subepithelial dystrophy 10.0 KRT12 TGFBI
15 epithelial-stromal tgfbi dystrophy 10.0 KRT12 TGFBI
16 astigmatism 10.0
17 macular dystrophy, corneal 10.0 KRT12 TGFBI
18 corneal dystrophy, meesmann 10.0 KRT12 TGFBI
19 anterior segment dysgenesis 9.9 TGFBI VSX1
20 corneal endothelial dystrophy 9.9 KRT12 TGFBI
21 keratopathy 9.9
22 fuchs' endothelial dystrophy 9.9 TGFBI VSX1
23 corneal dystrophy, posterior polymorphous, 1 9.8 TGFBI VSX1
24 graft-versus-host disease 9.8
25 cataract 9.8
26 epithelial basement membrane dystrophy 9.8
27 ichthyosis 9.8
28 vasculitis 9.8
29 lattice corneal dystrophy 9.8
30 chronic graft versus host disease 9.8
31 corneal dystrophy, thiel-behnke type 9.6 KRT12 LCAT SAT1 TGFBI
32 corneal disease 9.5 KRT12 LCAT TGFBI VSX1

Comorbidity relations with Corneal Degeneration via Phenotypic Disease Network (PDN):


Bullous Keratopathy

Graphical network of the top 20 diseases related to Corneal Degeneration:



Diseases related to Corneal Degeneration

Symptoms & Phenotypes for Corneal Degeneration

MGI Mouse Phenotypes related to Corneal Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 KRT12 LCAT SLC4A4 TGFBI VSX1

Drugs & Therapeutics for Corneal Degeneration

Drugs for Corneal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3 Anti-Ulcer Agents Phase 4
4 Gastrointestinal Agents Phase 4
5 Antacids Phase 4
6 Proton Pump Inhibitors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Lansoprazole in Patients With Reflux Disease Completed NCT01135368 Phase 4 Lansoprazole
2 Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders Unknown status NCT02444923 Not Applicable
3 A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea Recruiting NCT03220529 Not Applicable

Search NIH Clinical Center for Corneal Degeneration

Genetic Tests for Corneal Degeneration

Anatomical Context for Corneal Degeneration

MalaCards organs/tissues related to Corneal Degeneration:

41
Eye, Testes, Endothelial

Publications for Corneal Degeneration

Articles related to Corneal Degeneration:

(show top 50) (show all 102)
# Title Authors Year
1
Deep blue dot corneal degeneration: confocal characteristics. ( 29423782 )
2018
2
Acute hydrops with a 180-degree massive edematous cavern demonstrated by three dimensional view of anterior segment optical coherence tomography in a patient with pellucid marginal corneal degeneration, a case report. ( 29653558 )
2018
3
Lipoidal corneal degeneration in aged falcons. ( 29350449 )
2018
4
Corneal hysteresis and corneal resistance factor in pellucid marginal corneal degeneration. ( 29988910 )
2018
5
Crescentic Tuck in Lamellar Keratoplasty-A Novel Technique in a Case of Advanced Pellucid Marginal Corneal Degeneration. ( 30160655 )
2018
6
Stromal corneal dystrophy (possible Schnyder's dystrophy) with peripheral corneal degeneration - diagnostic and therapeutic challenges. ( 30206563 )
2018
7
Peripheral Hypertrophic Subepithelial Corneal Degeneration. ( 28594994 )
2017
8
An Unusual Corneal Degeneration. ( 28334307 )
2017
9
National survey of pellucid marginal corneal degeneration in Japan. ( 27401170 )
2016
10
Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses. ( 26773714 )
2016
11
Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing. ( 26024086 )
2015
12
Comparison of Scheimpflug imaging analysis of pellucid marginal corneal degeneration and keratoconus. ( 25504087 )
2015
13
Re: peripheral hypertrophic subepithelial corneal degeneration - clinical and histopathological features. ( 25809296 )
2015
14
Re: Gore et al.: Peripheral hypertrophic subepithelial corneal degeneration: nomenclature, phenotypes, and long-term outcomes (Ophthalmology 2013;120:892-8). ( 24484990 )
2014
15
Peripheral hypertrophic subepithelial corneal degeneration - clinical and histopathological features. ( 24655442 )
2014
16
Peripheral hypertrophic subepithelial corneal degeneration: characterization, treatment and association with human leucocyte antigen genes. ( 23388055 )
2014
17
Simultaneous conventional photorefractive keratectomy and corneal collagen cross-linking for pellucid marginal corneal degeneration. ( 24702579 )
2014
18
Peripheral hypertrophic subepithelial corneal degeneration presenting with bilateral nasal and temporal corneal changes. ( 25277306 )
2014
19
Combined tissue excision and corneal tuck for the surgical treatment of extremely advanced pellucid marginal corneal degeneration. ( 24162753 )
2013
20
Spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops. ( 23407319 )
2013
21
Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration. ( 24292162 )
2013
22
Peripheral hypertrophic subepithelial corneal degeneration: nomenclature, phenotypes, and long-term outcomes. ( 23474249 )
2013
23
Ring-shaped corneoscleral lamellar keratoplasty guided by high-definition optical coherence tomography and Scheimpflug imaging for severe Terrien's marginal corneal degeneration. ( 22573412 )
2012
24
Myxomatous corneal degeneration: a clinicopathological study of six cases and a review of the literature. ( 22370508 )
2012
25
Corneal changes after suspending contact lens wear in early pellucid marginal corneal degeneration and moderate keratoconus. ( 21336035 )
2011
26
Familial pattern of Salzmann-type nodular corneal degeneration a89 a four generation series. Reply to Papanikolaou et al. ( 21169267 )
2011
27
Salzmann's nodular corneal degeneration (SNCD): clinical findings, risk factors, prognosis and the role of previous contact lens wear. ( 21349758 )
2011
28
In vivo confocal microscopy in Terrien marginal corneal degeneration: a case report. ( 21282992 )
2011
29
A single 210-degree arc length intrastromal corneal ring implantation for the management of pellucid marginal corneal degeneration. ( 20570241 )
2010
30
Familial pattern of Salzmann-type nodular corneal degeneration--a four generation series. ( 20679082 )
2010
31
Bilateral Salzmann-like nodular corneal degeneration after laser in situ keratomileusis imaged with anterior segment optical coherence tomography and high-frequency ultrasound biomicroscopy. ( 19304107 )
2009
32
Management of pellucid marginal corneal degeneration with simultaneous customized photorefractive keratectomy and collagen crosslinking. ( 19545822 )
2009
33
Intracameral SF6 injection and anterior segment OCT-based documentation for acute hydrops management in pellucid marginal corneal degeneration. ( 18291707 )
2008
34
Histopathology of Salzmann nodular corneal degeneration. ( 18216567 )
2008
35
Combined wedge resection and beveled penetrating relaxing incisions for the treatment of pellucid marginal corneal degeneration. ( 18520511 )
2008
36
Characteristics of ocular higher-order aberrations in patients with pellucid marginal corneal degeneration. ( 19006740 )
2008
37
Ultraviolet radiation-induced corneal degeneration in 129 mice. ( 17943656 )
2007
38
Salzmann's nodular corneal degeneration clinical characteristics and surgical outcomes. ( 16331034 )
2006
39
Pellucid marginal corneal degeneration: evaluation of the corneal surface and contact lens fitting. ( 16488954 )
2006
40
Intrastromal ring segment insertion using a femtosecond laser to correct pellucid marginal corneal degeneration. ( 17010872 )
2006
41
Reduction of hyperopia and astigmatism after superficial keratectomy of peripheral hypertrophic subepithelial corneal degeneration. ( 16702871 )
2006
42
Recurrent corneal perforation and acute calcareous corneal degeneration in chronic graft-versus-host disease. ( 16618614 )
2006
43
Management of pellucid marginal corneal degeneration. ( 15968160 )
2005
44
Bitoric gas-permeable contact lens application in pellucid marginal corneal degeneration. ( 16163019 )
2005
45
Compressive C-shaped lamellar keratoplasty: a surgical alternative for the management of severe astigmatism from peripheral corneal degeneration. ( 15745769 )
2005
46
Superior pellucid marginal corneal degeneration. ( 15069437 )
2004
47
Lamellar crescentic resection for pellucid marginal corneal degeneration. ( 15072316 )
2004
48
Pellucid marginal corneal degeneration. ( 15177959 )
2004
49
Implantation of a toric phakic intraocular lens to correct high corneal astigmatism in a patient with bilateral marginal corneal degeneration. ( 15030849 )
2004
50
Ferrara intracorneal ring implantation and cataract surgery for the correction of pellucid marginal corneal degeneration. ( 15519101 )
2004

Variations for Corneal Degeneration

Expression for Corneal Degeneration

Search GEO for disease gene expression data for Corneal Degeneration.

Pathways for Corneal Degeneration

GO Terms for Corneal Degeneration

Biological processes related to Corneal Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 8.96 LCAT MBTPS2
2 visual perception GO:0007601 8.8 KRT12 TGFBI VSX1

Sources for Corneal Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....