Corneal Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Corneal Disease

MalaCards integrated aliases for Corneal Disease:

Name: Corneal Disease 12 15 17
Corneal Diseases 54 44 70
Corneal Disorders 42


External Ids:

Disease Ontology 12 DOID:10124
ICD9CM 34 371.9
MeSH 44 D003316
NCIt 50 C26731
SNOMED-CT 67 15250008
ICD10 32 H18.9
UMLS 70 C0010034

Summaries for Corneal Disease

MedlinePlus : 42 Your cornea is the outermost layer of your eye. It is clear and shaped like a dome. The cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. It also helps your eye to focus. If you wear contact lenses, they float on top of your corneas. Problems with the cornea include Refractive errors Allergies Infections Injuries Dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material Treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. NIH: National Eye Institute

MalaCards based summary : Corneal Disease, also known as corneal diseases, is related to corneal dystrophy, avellino type and keratitis, hereditary, and has symptoms including eye manifestations An important gene associated with Corneal Disease is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways/superpathways is Hypertrophy Model. The drugs Dextrans and Anticoagulants have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction.

Wikipedia : 73 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

Related Diseases for Corneal Disease

Diseases in the Corneal Disease family:

Rare Inflammatory/autoimmune Corneal Disorder Rare Corneal Disorder

Diseases related to Corneal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, avellino type 31.8 TGFBI KRT3 KRT12 CRYAA CHST6
2 keratitis, hereditary 31.8 NLRP3 NGF KRT3 KERA IL1A GJB2
3 corneal dystrophy, meesmann, 1 31.8 TGFBI LCAT KRT3 KRT12 COL8A2 CHST6
4 keratoconus 31.7 VSX1 TGFBI TGFB2 SLC4A11 KRT3 KRT12
5 keratopathy 31.0 TGFB2 KRT12 IL1A
6 keratoconjunctivitis sicca 30.7 NGF IL1A CCR6
7 eye disease 30.7 TGFBI TGFB2 LCAT IL1A CRYAA CCR6
8 recurrent corneal erosion 30.7 TGFBI KRT3 KRT12 COL8A2 CHST6
9 astigmatism 30.6 VSX1 KRT3 KRT12 KERA CRYAA
10 limbal stem cell deficiency 30.6 KRT3 KRT12 IL1A
11 corneal ulcer 30.5 NGF KRT3 KERA IL1A
12 corneal edema 30.5 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KERA
13 intraocular pressure quantitative trait locus 30.4 ZEB1 TGFB2 CRYAA
14 corneal ectasia 30.3 VSX1 TGFBI KRT3 KERA COL8A2
15 corneal dystrophy 30.2 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
16 corneal dystrophy, posterior polymorphous, 1 30.2 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
17 macular dystrophy, corneal 30.2 TGFBI KRT3 KRT12 KERA CHST6
18 lattice corneal dystrophy 30.2 TGFBI KRT3 KRT12 GSN CHST6
19 granular corneal dystrophy 30.2 TGFBI SLC4A11 KRT3 KRT12 COL8A2 CHST6
20 aniridia 1 30.2 KRT3 KRT12 CRYAA
21 corneal dystrophy, gelatinous drop-like 30.2 TGFBI KRT3 KRT12 GSN COL8A2 CHST6
22 glaucoma, primary open angle 30.1 TGFB2 CRYAA COL8A2
23 open-angle glaucoma 30.1 TGFB2 IL1A CRYAA COL8A2
24 fuchs' endothelial dystrophy 30.0 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
25 stromal dystrophy 30.0 TGFBI SLC4A11 KRT3 KRT12 KERA COL8A2
26 irregular astigmatism 30.0 VSX1 TGFBI SLC4A11 KRT3 KRT12 KERA
27 corneal degeneration 29.9 VSX1 TGFBI SLC4A11 KRT3 KRT12 KERA
28 keratoendotheliitis fugax hereditaria 11.0
29 keratoconus 9 11.0
30 corneal dystrophy, fuchs endothelial, 2 10.9
31 corneal dystrophy, fuchs endothelial, 3 10.9
32 corneal dystrophy, fuchs endothelial, 1 10.8
33 ring dermoid of cornea 10.8
34 megalocornea 10.8
35 peters-plus syndrome 10.8
36 corneal dystrophy, fuchs endothelial, 4 10.8
37 corneal dystrophy, fuchs endothelial, 6 10.8
38 corneal dystrophy, fuchs endothelial, 8 10.8
39 corneal dystrophy, meesmann, 2 10.8
40 sclerocornea 10.8
41 cornea plana 10.8
42 posterior corneal dystrophy 10.5 ZEB1 COL8A2
43 cicatricial entropion 10.5 TFF3 KRT3
44 corneal dystrophy, lisch epithelial 10.5 KRT3 KRT12 CHST6
45 corneal dystrophy, groenouw type i 10.5 TGFBI KRT12 CHST6
46 pseudopterygium 10.5 SLC4A11 KRT3 KRT12
47 schnyder corneal dystrophy 10.5 TGFBI KRT3 KRT12
48 epithelial basement membrane dystrophy 10.5 TGFBI KRT3 CHST6
49 interstitial keratitis 10.5 TGFBI CRYAA COL8A2
50 secondary corneal edema 10.5 SLC4A11 COL8A2

Graphical network of the top 20 diseases related to Corneal Disease:

Diseases related to Corneal Disease

Symptoms & Phenotypes for Corneal Disease

UMLS symptoms related to Corneal Disease:

eye manifestations

GenomeRNAi Phenotypes related to Corneal Disease according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.58 GSN
2 Decreased viability GR00055-A-2 9.58 GSN
3 Decreased viability GR00055-A-3 9.58 GSN
4 Decreased viability GR00249-S 9.58 CRYAA IL1A TGFBI
5 Decreased viability GR00386-A-1 9.58 AGBL1 KERA NGF NLRP3 SLC4A11 TGFB2
6 Decreased viability GR00402-S-2 9.58 CRYAA GJB2 KRT3 LCAT TGFBI

MGI Mouse Phenotypes related to Corneal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 AGBL1 CCR6 GJB2 GSN IL1A KERA
2 vision/eye MP:0005391 9.44 AGBL1 CHST6 COL8A2 GJB2 KERA KRT12

Drugs & Therapeutics for Corneal Disease

Drugs for Corneal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dextrans Phase 3
2 Anticoagulants Phase 3
3 Plasma Substitutes Phase 3
4 Blood Substitutes Phase 3
5 Cyclosporins Phase 3
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
Betamethasone Approved, Vet_approved Phase 1, Phase 2 378-44-9 9782
Hyaluronic acid Approved, Vet_approved Phase 1, Phase 2 9004-61-9 53477741
10 Antibiotics, Antitubercular Phase 1, Phase 2
11 Anti-Bacterial Agents Phase 1, Phase 2
12 Hormone Antagonists Phase 1, Phase 2
13 Hormones Phase 1, Phase 2
14 Anti-Inflammatory Agents Phase 1, Phase 2
15 glucocorticoids Phase 1, Phase 2
16 Anti-Infective Agents Phase 1, Phase 2
17 Anti-Asthmatic Agents Phase 1, Phase 2
18 Respiratory System Agents Phase 1, Phase 2
19 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
Tobramycin Approved, Investigational 32986-56-4 5496 36294
Neomycin Approved, Vet_approved 1404-04-2 8378
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
Polymyxin B Approved, Vet_approved 1404-26-8
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
Homatropine Approved 87-00-3
Latanoprost Approved, Investigational 130209-82-4 5282380 5311221
Tacrolimus Approved, Investigational 104987-11-3 6473866 445643 439492
Methylcobalamin Approved, Investigational 13422-55-4
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
Flavin mononucleotide Approved, Investigational 146-17-8 643976
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
Cobalamin Experimental 13408-78-1 6857388
33 Tobramycin, Dexamethasone Drug Combination
34 Neurotransmitter Agents
35 Adrenergic alpha-Agonists
36 Adrenergic Agents
37 Brimonidine Tartrate 70359-46-5
38 Adrenergic Agonists
39 Mitomycins
40 Alkylating Agents
41 Polymyxins
42 Antiemetics
43 Parasympatholytics
44 Antineoplastic Agents, Hormonal
45 Dexamethasone, neomycin, polymyxin B drug combination
46 Antihypertensive Agents
47 Immunosuppressive Agents
48 Calcineurin Inhibitors
49 Cytidine Diphosphate Choline
50 Vitamin B12

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Ocular Surface Conditions in Asian Glaucoma Patients With Existing Corneal Disorders Switching From Preserved Prostaglandin Analogues Monotherapy to Preservative-free Tafluprost Completed NCT04654611 Phase 4 preservative free tafluprost 0.0015%
2 Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Hypo-osmolar Riboflavin Solution in Thin Corneas Completed NCT01485211 Phase 4 cross-linking with hypo-osmolar riboflavin
3 Effect of Corneal Preservation Time on Long-Term Graft Success Completed NCT01537393 Phase 4
4 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Unknown status NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
5 Study of Safety and Efficacy of Photochemically Induced Collagen Cross-Linking at an Irradiance of 18 mW/cm2 as Constant or Pulsed Treatment in Eyes With Unstable Corneas Due to Keratoconus, Ectasia, or Post-Incisional Refractive Surgery Unknown status NCT02095730 Phase 3 Epithelium-On Riboflavin;Epithelium-Off Riboflavin
6 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
7 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
8 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
9 A Multi-center, Placebo-Controlled, Randomized, Parallel Group, Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure Following Penetrating Keratoplasty With LX201 Implantation in Subjects Who Are at Increased Immunological Risk Terminated NCT00447187 Phase 3 LX201
10 Topography Guided Excimer Laser Surface Ablation in Combination With Corneal Cross-linking (CCL) in Patients With Progressive Ectatic Corneal Disorders. Terminated NCT01682993 Phase 3
11 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
12 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
13 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
14 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
15 Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation Unknown status NCT02148016 Phase 1, Phase 2 Levofloxacin;Betamethasone;Limbal stem cells (LSCs)
16 Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Limbal Stem Cells (Corneal Epithelial Stem Cells) or Adipose-derived Mesenchymal Stem Cells Completed NCT04484402 Phase 1, Phase 2
17 A Controlled Phase 2 Study for Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel Recruiting NCT03994406 Phase 2 CLM2 topical gel;Placebo topical gel
18 Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas Terminated NCT03029104 Phase 2
19 The Improvement of Limbal Epithelial Culture Technique for the Treatment of Unilateral Limbal Insufficiency by Using Collagenase to Isolate Limbal Stem Cells Unknown status NCT02202642 Phase 1
20 Phase I Study to Evaluate Safety of LSCD101(Cultured Autologous Limbal Epithelial Cell Sheet) Transplantation for Limbal Stem Cell Deficiency Completed NCT04773431 Phase 1 LSCD101 (Cultured Autologous Limbal Epithelial Cell Sheet) transplantation
21 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Recruiting NCT04094090 Phase 1
22 Evaluation of Biosynthetic Constructs as Replacement for Donor Corneas as Graft Material for Corneal Transplantation Withdrawn NCT02374723 Phase 1
23 Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases Unknown status NCT02932852 Early Phase 1
24 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
25 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Unknown status NCT03105466 Tacrolimus eye drops;Tobradex eyedrops
26 Effect of Brimonidine on Corneal Thickness Unknown status NCT01250236 brimonidine 0.1%;placebo
27 Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI Unknown status NCT01307527 Riboflavin
28 Age-dependency of Cornea Biomechanics Measured by OCT Vibrography: A Pilot Study Unknown status NCT03230981
29 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
30 A Single Center, Randomized, Controlled, Single-Masked, Cross-Over Clinical Pilot Study to Evaluate the Reduction in the Exacerbation of the Symptoms of Dry Eye Upon Exposure to a Controlled Adverse Environment (CAESM) With Treatment by the Oculeve Nasal Lacrimal TENS Unit Completed NCT02313454
31 Topical Dehydrex in Treating Recurrent Corneal Erosion Completed NCT00029185 Dehydrex
32 Phase 1 Study of in Vivo Confocal Microscope to Evaluate the Corneal Wound Healing After Various Ocular Surgeries Completed NCT00491439
33 Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy Completed NCT02344732 Dexamethasone 0.1%, Neomycin Sulfate and Polymyxin B Sulfate topical eye drops four times daily;Homatropine 2% eye drops thrice daily;Oxygen gas
34 Corneal Analysis - Pathology Detection Aid Completed NCT00396188
35 Topical Autologous Serum Eye Drops Combined With Silicone Hydrogen Lenses for theTreatment of Corneal Epithelial Defects Completed NCT02291731 Continuous use of topical autologous serum
36 A Pilot Study Using the Dynamic Light Scattering Device (DLS) Combined With Keratoscopy on the Cornea in Vivo Completed NCT00050466
37 Ocular Surface Disorders in Patients in Intensive Care Units, a Comparative Study Completed NCT02348242
38 Clinical Trial to Investigate Superiority of HLA Matching in Comparison to Random Graft Assignment With Respect to the Endpoint 'Time to First Endothelial Graft Rejection' in Penetrating Keratoplasty. Completed NCT00810472
39 Clinical and Molecular Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases Completed NCT00357435
40 Prospective, Single Center Switching Study of 0.0015% Tafluprost Ophthalmic Solution in Primary Open-angle Glaucoma and Ocular Hypertension Patients With Corneal Disorders Completed NCT04737928 Latanoprost;tafluprost
41 Cornea Donor Study: The Effect of Donor Age on Penetrating Keratoplasty for Endothelial Disease Completed NCT00006411
42 A 90 Day Multi-Center, Randomized, Parallel Group Daily Wear Investigation of a New Hybrid Lens SynergEyes SA Manufactured With a Rigid Gas Permeable Center (Petrafocon A) and a Silicone Hydrogel Skirt (Larafilcon A) Compared to SynergEyes A (Paflufocon D Hem-iberfilcon A) Completed NCT00804505
43 Corneal Densitometry Changes With Adenoviral Keratoconjunctivitis Sub Epithelial Infiltrates Completed NCT04267991 Tacrolimus ointment
44 Evaluation of RTVue in Corneal Measurement Completed NCT01220193
45 Evaluation of the Efficacy of OMK2 in Recovering Corneal Neural Damage in Patients With Diabetes Completed NCT03906513
46 The Efficacy of a 6-point Transscleral Suture Fixation of a 3-looped Haptics PC-IOL Implantation Through Scleral Pockets for Surgical Management for Microspherophakia Completed NCT04447157
47 Evaluation and Treatment of Corneal and External Diseases and Anterior Segment Disorders Completed NCT00008541
48 Evaluation Of A New Disposable Contact Lens Patient Interface For The Lensx Laser In Cataract And Corneal Surgery Completed NCT01141985 Early Phase 1
49 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Completed NCT03706443
50 A Prospective, Randomized, Open Label Clinical Trial to Evaluate the Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea Compared to Human Cornea in Patients Requiring Anterior Lamellar Keratoplasty Completed NCT02424006

Search NIH Clinical Center for Corneal Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :

deferoxamine mesylate

Cochrane evidence based reviews: corneal diseases

Genetic Tests for Corneal Disease

Anatomical Context for Corneal Disease

MalaCards organs/tissues related to Corneal Disease:

Eye, Endothelial, Neutrophil, Skin, T Cells, Bone Marrow, Bone

Publications for Corneal Disease

Articles related to Corneal Disease:

(show top 50) (show all 1906)
# Title Authors PMID Year
Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis. 61 42
33462242 2021
Impact of nationwide COVID-19 lockdown on keratoplasty and eye banking in India: A survey of cornea surgeons and eye banks. 42
33595505 2021
A Foldable Nonpenetrating Keratoprosthesis: Medium to Long-Term Clinical Results in Patients with Corneal Blindness due to Noninflammatory Anterior Cornea Disease. 42
33488010 2020
Anterior segment dysgenesis after overexpression of transforming growth factor-beta-induced gene, beta igh3, in the mouse eye. 61 54
17982418 2007
Expression of Sp1 and KLF6 in the developing human cornea. 54 61
17893646 2007
Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene. 61 54
17653042 2007
[Autosomal dominant granular corneal dystrophy caused by a TGFBI gene mutation in a Mexican family]. 61 54
16888689 2006
Keratoepithelin in secondary corneal amyloidosis. 54 61
16331487 2006
Influence of interleukin-1alpha and tumor necrosis factor-alpha production on corneal graft survival. 54 61
16489698 2006
Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. 54 61
16083875 2006
The molecular genetics of the corneal dystrophies--current status. 54 61
12700042 2003
Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. 54 61
12140204 2002
Cell density regulated expression of transcription factor Sp1 in corneal stromal cultures. 54 61
11428859 2001
Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas. 54 61
10752942 2000
Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study. 54 61
8776562 1996
Nocardia keratitis mimicking superior limbic keratoconjunctivitis and herpes simplex virus. 61
33665477 2021
Long-term Results of a Combined Procedure of Cataract Surgery and Descemet Membrane Endothelial Keratoplasty With Stromal Rim. 61
33156081 2021
Rate of Corneal Grafting Post-Glaucoma Drainage Device Use in Pediatric and Adult Patients. 61
33350658 2021
Evolution of therapies for the corneal endothelium: past, present and future approaches. 61
32709756 2021
Medication Adherence Among Patients With Corneal Diseases. 61
33661137 2021
Integrated contact lens sensor system based on multifunctional ultrathin MoS2 transistors. 61
33398259 2021
Determination of Copper by AAS in Tear Fluid of Patients with Keratoconus. 61
33766579 2021
Application of Artificial Intelligence in the Diagnosis and Management of Corneal Diseases. 61
33689543 2021
Evaluation of equine corneal disease using ultrasound biomicroscopy. 61
33694251 2021
In situ forming and mucoadhesive ophthalmic voriconazole/HPβCD hydrogels for the treatment of fungal keratitis. 61
33540021 2021
On the Horizon: Biologics and Nutrients for Neurotrophic Keratitis. 61
33156130 2021
American Academy of Optometry Microbial Keratitis Think Tank. 61
33771951 2021
Aqueous Misdirection After Trabeculectomy in a Down Syndrome Patient with Angle-closure Glaucoma. 61
33710067 2021
Retrospective analysis of ocular disease in a population of captive pteropodid bats, 2003-2020. 61
33682341 2021
Swept Source Optical Coherence Tomography Analysis of the Selected Eye's Anterior Segment Parameters. 61
33807917 2021
One-Year Clinical Outcomes of Preloaded Descemet Membrane Endothelial Keratoplasty Versus Non-Preloaded Descemet Membrane Endothelial Keratoplasty. 61
32740011 2021
Development of a deep learning-based image quality control system to detect and filter out ineligible slit-lamp images: A multicenter study. 61
33765481 2021
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses. 61
33785451 2021
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus. 61
33649486 2021
Temporary Keratoprosthesis with Penetrating Keratoplasty in Conjunction with Pars Plana Vitrectomy for Repair of Retinal Detachments in Patients with Anterior and Posterior Segment Pathology. 61
33555819 2021
Integrated Intraoperative Optical Coherence Tomography for Pediatric Lamellar Corneal Transplant Surgery. 61
33621974 2021
Microbial keratitis in a tertiary centre in Queensland, Australia (1999-2015). 61
33689640 2021
New perspectives in keratoconus treatment: an update on iontophoresis-assisted corneal collagen crosslinking. 61
33590372 2021
Exacerbation of Granular Corneal Dystrophy Type 2 After Small Incision Lenticule Extraction. 61
33560675 2021
Cost-effectiveness analysis of preloaded versus non-preloaded Descemet membrane endothelial keratoplasty for the treatment of Fuchs endothelial corneal dystrophy in an academic centre. 61
33637619 2021
Effectiveness of Pulmonary Surfactant in the Treatment of Corneal Edema. 61
33555974 2021
Iatrogenic corneal diseases or conditions. 61
33279524 2021
Functional reallocation of sensory processing resources caused by long-term neural adaptation to altered optics. 61
33616034 2021
Pediatric keratoconus - Current perspectives and clinical challenges. 61
33463562 2021
Stem cell-based therapeutic strategies for corneal epithelium regeneration. 61
33248403 2021
Galectins as Regulators of Corneal Inflammation. 61
32954114 2021
Proteome Composition of Bovine Amniotic Membrane and Its Potential Role in Corneal Healing. 61
33560292 2021
Health Potential of Aloe vera against Oxidative Stress Induced Corneal Damage: An "In Vitro" Study. 61
33672553 2021
Super-resolution imaging of flat-mounted whole mouse cornea. 61
33610603 2021
Hyaluronic acid and graphene oxide loaded silicon contact lens for corneal epithelial healing. 61
33058750 2021

Variations for Corneal Disease

Expression for Corneal Disease

Search GEO for disease gene expression data for Corneal Disease.

Pathways for Corneal Disease

Pathways related to Corneal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.92 ZEB1 IL1A

GO Terms for Corneal Disease

Cellular components related to Corneal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TGFBI TGFB2 TFF3 NGF LCAT KERA
2 extracellular region GO:0005576 9.32 TGFBI TGFB2 TFF3 NLRP3 NGF LCAT

Biological processes related to Corneal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration involved in inflammatory response GO:0002523 9.16 NLRP3 CCR6
2 visual perception GO:0007601 9.02 VSX1 TGFBI KRT12 KERA CRYAA
3 cornea development in camera-type eye GO:0061303 8.96 KRT12 KERA

Sources for Corneal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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