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MCID: CRN024
MIFTS: 44

Corneal Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Corneal Disease

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MalaCards integrated aliases for Corneal Disease:

Name: Corneal Disease 12 15 17
Corneal Diseases 54 43 71
Corneal Disorders 42

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10124
ICD9CM 34 371.9
MeSH 43 D003316
NCIt 49 C26731
SNOMED-CT 67 15250008
ICD10 32 H18.9
UMLS 71 C0010034
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Summaries for Corneal Disease

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MedlinePlus : 42 Your cornea is the outermost layer of your eye. It is clear and shaped like a dome. The cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. It also helps your eye to focus. If you wear contact lenses, they float on top of your corneas. Problems with the cornea include Refractive errors Allergies Infections Injuries Dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material Treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. NIH: National Eye Institute

MalaCards based summary : Corneal Disease, also known as corneal diseases, is related to keratitis, hereditary and keratoconus, and has symptoms including eye manifestations An important gene associated with Corneal Disease is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways/superpathways is Hypertrophy Model. The drugs Acetazolamide and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction.

Wikipedia : 74 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

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Related Diseases for Corneal Disease

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Diseases in the Corneal Disease family:

Rare Inflammatory/autoimmune Corneal Disorder Rare Corneal Disorder

Diseases related to Corneal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 32.9 NLRP3 KRT3 GJB2 CRYAA CCR6
2 keratoconus 32.5 VSX1 TGFBI TGFB2 SLC4A11 KRT3 KRT12
3 corneal dystrophy and perceptive deafness 32.3 VSX1 SLC4A11 COL8A2
4 corneal dystrophy, avellino type 32.3 TGFBI KRT3 KRT12 COL8A2 CHST6
5 corneal dystrophy, meesmann, 1 32.2 TGFBI LCAT KRT3 KRT12 COL8A2 CHST6
6 keratopathy 31.4 TGFB2 KRT12 IL1A
7 astigmatism 31.2 KRT3 KRT12 CRYAA
8 limbal stem cell deficiency 31.0 KRT3 KRT12 IL1A
9 corneal edema 31.0 ZEB1 VSX1 SLC4A11 KRT3 KERA COL8A2
10 keratoconjunctivitis sicca 30.9 NGF IL1A CCR6
11 eye disease 30.8 TGFBI TGFB2 NGF LCAT IL1A CRYAA
12 recurrent corneal erosion 30.8 TGFBI KRT3 KRT12 COL8A2 CHST6
13 corneal dystrophy 30.8 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
14 corneal ectasia 30.8 VSX1 KRT3 KERA COL8A2
15 corneal ulcer 30.7 NGF KRT3 KERA IL1A
16 fuchs' endothelial dystrophy 30.7 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KERA
17 irregular astigmatism 30.6 VSX1 TGFBI SLC4A11 KRT3 KRT12 KERA
18 dry eye syndrome 30.5 NGF CRYAA CCR6
19 corneal dystrophy, band-shaped 30.5 SLC4A11 COL8A2
20 intraocular pressure quantitative trait locus 30.4 ZEB1 TGFB2 CRYAA
21 stromal dystrophy 30.4 TGFBI SLC4A11 KRT3 KRT12 KERA COL8A2
22 lattice corneal dystrophy 30.4 TGFBI KRT12 GSN CHST6
23 corneal dystrophy, posterior polymorphous, 1 30.4 ZEB1 VSX1 TGFBI SLC4A11 KRT3 KRT12
24 aniridia 1 30.3 KRT3 KRT12 CRYAA
25 glaucoma, primary open angle 30.3 TGFB2 CRYAA COL8A2
26 corneal dystrophy, gelatinous drop-like 30.3 TGFBI KRT3 KRT12 GSN COL8A2 CHST6
27 corneal degeneration 30.2 VSX1 TGFBI SLC4A11 KRT3 KRT12 COL8A2
28 macular dystrophy, corneal 30.2 TGFBI SLC4A11 KRT3 KRT12 KERA COL8A2
29 open-angle glaucoma 30.1 TGFB2 CRYAA COL8A2
30 rare inflammatory/autoimmune corneal disorder 12.1
31 rare corneal disorder 12.1
32 rare genetic inflammatory/autoimmune corneal disorder 12.1
33 rare genetic corneal disorder 12.1
34 keratoendotheliitis fugax hereditaria 11.4
35 corneal dystrophy, fuchs endothelial, 1 11.3
36 keratoconus 9 11.1
37 ring dermoid of cornea 10.9
38 megalocornea 10.9
39 peters-plus syndrome 10.9
40 corneal dystrophy, fuchs endothelial, 4 10.9
41 corneal dystrophy, fuchs endothelial, 6 10.9
42 corneal dystrophy, fuchs endothelial, 8 10.9
43 corneal dystrophy, meesmann, 2 10.9
44 sclerocornea 10.9
45 cornea plana 10.9
46 corneal dystrophy, fuchs endothelial, 2 10.9
47 corneal dystrophy, fuchs endothelial, 3 10.9
48 pseudopterygium 10.7 SLC4A11 KRT3 KRT12
49 posterior corneal dystrophy 10.7 ZEB1 COL8A2
50 corneal dystrophy, lisch epithelial 10.7 KRT3 KRT12 CHST6

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to Corneal Disease
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Symptoms & Phenotypes for Corneal Disease

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UMLS symptoms related to Corneal Disease:


eye manifestations

GenomeRNAi Phenotypes related to Corneal Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.58 GSN
2 Decreased viability GR00055-A-2 9.58 GSN
3 Decreased viability GR00055-A-3 9.58 GSN
4 Decreased viability GR00249-S 9.58 CRYAA IL1A TGFBI
5 Decreased viability GR00386-A-1 9.58 AGBL1 KERA NGF NLRP3 SLC4A11 TGFB2
6 Decreased viability GR00402-S-2 9.58 CRYAA GJB2 KRT3 LCAT TGFBI

MGI Mouse Phenotypes related to Corneal Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 AGBL1 CCR6 GJB2 GSN IL1A KERA
2 vision/eye MP:0005391 9.4 CHST6 COL8A2 GJB2 KERA KRT12 LCAT
Sources

Drugs & Therapeutics for Corneal Disease

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Drugs for Corneal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 131)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
4
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
5
Timolol Approved Phase 4 26839-75-8 5478 33624
6
tannic acid Approved Phase 4 1401-55-4
7
Brinzolamide Approved Phase 4 138890-62-7 68844
8
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
9
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
10 Lubricant Eye Drops Phase 4
11 Adrenergic alpha-Agonists Phase 4
12 Antihypertensive Agents Phase 4
13 Adrenergic Agents Phase 4
14 Adrenergic Agonists Phase 4
15 Brimonidine Tartrate Phase 4 70359-46-5
16 Mitogens Phase 4
17 Adrenergic beta-Antagonists Phase 4
18 Carbonic Anhydrase Inhibitors Phase 4
19
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
20
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
21
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
22
Ofloxacin Approved Phase 3 82419-36-1 4583
23
Tobramycin Approved, Investigational Phase 3 32986-56-4 36294 5496
24
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
25
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
26
Gatifloxacin Approved, Investigational Phase 3 112811-59-3 5379
27
Cefazolin Approved Phase 3 25953-19-9 656510 33255
28
Cyclopentolate Approved Phase 3 512-15-2 2905
29
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
30
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
31
Tetracaine Approved, Vet_approved Phase 3 94-24-6 5411
32
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
33
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
34
Besifloxacin Approved Phase 3 141388-76-3
35 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
36
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
37
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
38
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
39
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
40 Endothelial Growth Factors Phase 2, Phase 3
41 triamcinolone acetonide Phase 2, Phase 3
42 Triamcinolone diacetate Phase 2, Phase 3
43 Angiogenesis Inhibitors Phase 2, Phase 3
44 Triamcinolone hexacetonide Phase 2, Phase 3
45 Antineoplastic Agents, Immunological Phase 2, Phase 3
46 Ophthalmic Solutions Phase 3
47 Anti-Bacterial Agents Phase 3
48 Antibiotics, Antitubercular Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 3
50 Anti-Infective Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 106)
# Name Status NCT ID Phase Drugs
1 Randomized, Parallel Groups, Multicenter and Blind to Evaluators Clinical Trial, to Evaluate the Efficacy and Safety of PRGF-Endoret Eye Drops, in Patients With Stage 2 and 3 Neurotrophic Keratitis Unknown status NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
2 Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves Unknown status NCT01535768 Phase 4 Aqueous Suppressant Eye Drops
3 Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Hypo-osmolar Riboflavin Solution in Thin Corneas Completed NCT01485211 Phase 4 cross-linking with hypo-osmolar riboflavin
4 Effect of Corneal Preservation Time on Long-Term Graft Success Completed NCT01537393 Phase 4
5 Intrastromal Corneal Ring Segment Implantation for High Astigmatism on Postkeratoplasty Eyes Completed NCT01018797 Phase 4
6 Study of Safety and Efficacy of Photochemically Induced Collagen Cross-Linking at an Irradiance of 18 mW/cm2 as Constant or Pulsed Treatment in Eyes With Unstable Corneas Due to Keratoconus, Ectasia, or Post-Incisional Refractive Surgery Unknown status NCT02095730 Phase 3 Epithelium-On Riboflavin;Epithelium-Off Riboflavin
7 iDesign Aberrometer for the Refractive Treatment of Early Keratoconus Unknown status NCT02613780 Phase 3
8 A Phase III Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome Completed NCT02503189 Phase 3 KCT-0809 ophthalmic solution;Placebo
9 A Long-term Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome Completed NCT02503163 Phase 3 KCT-0809 ophthalmic solution
10 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia or Progressive Keratoconus Completed NCT00567671 Phase 2, Phase 3
11 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
12 Phase 3, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy: SEER-1 Recruiting NCT02600429 Phase 3 RGN-259;Placebo
13 Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3 Cefazolin in combination with either tobramycin or gentamicin;Cycloplegic agents (cyclopentolate 1% eye drops);Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin );Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
14 Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking and Intacs for Treatment of Keratoconus and Corneal Ectasia Active, not recruiting NCT01112072 Phase 3 Riboflavin
15 Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Active, not recruiting NCT01464268 Phase 3 Riboflavin;Riboflavin
16 Comparison of Autologous Serum 20% and Autologous Serum 50% for the Treatment of Severe Dry Eye Enrolling by invitation NCT03436576 Phase 3 Autologous Serum 20%;Autologous Serum 50%
17 Topography Guided Excimer Laser Surface Ablation in Combination With Corneal Cross-linking (CCL) in Patients With Progressive Ectatic Corneal Disorders. Terminated NCT01682993 Phase 3
18 An Extension Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome Terminated NCT02503176 Phase 3 KCT-0809 ophthalmic solution
19 Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery Terminated NCT01459679 Phase 3 riboflavin ophthalmic solution
20 A Multi-center, Placebo-Controlled, Randomized, Parallel Group, Dose-Ranging Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure Following Penetrating Keratoplasty With LX201 Implantation in Subjects Who Are at Increased Immunological Risk Terminated NCT00447187 Phase 3 LX201
21 Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Withdrawn NCT00679666 Phase 2, Phase 3 Riboflavin;Placebo
22 A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery Withdrawn NCT01643252 Phase 3 riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system;placebo: 0.0% riboflavin ophthalmic solution with the KXL system
23 Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation Unknown status NCT02148016 Phase 1, Phase 2 Levofloxacin;Betamethasone;Limbal stem cells (LSCs)
24 UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia Unknown status NCT01325298 Phase 2 Riboflavin;Riboflavin
25 A Randomized, Double Blind, Placebo Controlled, Phase 2 Study of KLS-0611 in Patients With Dry Eye Syndromes Completed NCT00721656 Phase 2 Placebo;KLS-0611
26 A Randomized, Double Blind, Placebo Controlled, Phase II Study of KCT-0809 in Patients With Dry Eye Syndrome Completed NCT01427816 Phase 2 KCT-0809;KCT-0809;Placebo
27 A Late Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes Completed NCT01890941 Phase 2 KCT-0809 ophthalmic solution;Placebo
28 A Randomized, Double Blind, Placebo Controlled, Exploratory Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes Completed NCT01211951 Phase 2 KCT-0809;KCT-0809;KCT-0809;Placebo
29 A Randomized, Double Blind, Placebo Controlled, Parallel Group Phase II Study of KCT-0809 in Patients With Dry Eye Syndromes Completed NCT01692145 Phase 2 KCT-0809;Placebo
30 Evaluation the Effect of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Epithelium Healing (Phase I and II Clinical Trial) Completed NCT02746848 Phase 1, Phase 2
31 Safety and Efficacy of Topical Pazopanib in Treatment of Corneal Neovascularization Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
32 A Controlled Phase 2 Study for Prolongation of Contact Lens Comfortable Wear Duration by CLM2 Topical Gel Recruiting NCT03994406 Phase 2 CLM2 topical gel;Placebo topical gel
33 Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas Terminated NCT03029104 Phase 2
34 The Improvement of Limbal Epithelial Culture Technique for the Treatment of Unilateral Limbal Insufficiency by Using Collagenase to Isolate Limbal Stem Cells Unknown status NCT02202642 Phase 1
35 Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia Recruiting NCT04094090 Phase 1
36 Evaluation of Biosynthetic Constructs as Replacement for Donor Corneas as Graft Material for Corneal Transplantation Withdrawn NCT02374723 Phase 1
37 Effect of Brimonidine on Corneal Thickness Unknown status NCT01250236 brimonidine 0.1%;placebo
38 Implant the Corneal Stroma to the Diseased Cornea in Order to Cure Keratoconus Unknown status NCT03229239
39 Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VI Unknown status NCT01307527 Riboflavin
40 Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia Unknown status NCT01123057
41 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Unknown status NCT03105466 Tacrolimus eye drops;Tobradex eyedrops
42 Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases Unknown status NCT02932852 Early Phase 1
43 Observation on Effect of Anti--inflammatory and Inhibition of Recurrence on the Herpes Simplex Keratitis After Topical NSAIDs Administration Unknown status NCT03013959 Pranoprofen
44 Using AS-OCT to Assess the Role of Age and Region in the Morphology and Epithelial Thickness of Limbus Unknown status NCT02500134
45 The Effect of Ophthalmic Solutions on Contact Lenses Used After Surgery for Congenital Cataract Investigated in Vivo Unknown status NCT03125785
46 The Asia Cornea Society Infectious Keratitis Study Unknown status NCT01560208
47 Retrospective Study of the in Vivo Confocal Microscopic Findings and the Treatment Outcome of Acanthamoebic Keratitis Unknown status NCT02763605
48 Corneal Endothelial Cell Loss After Trabeculectomy Versus Combined Trabeculectomy Phakoemulsification and IOL Implantation Unknown status NCT03107000
49 A Pilot Study Using the Dynamic Light Scattering Device (DLS) Combined With Keratoscopy on the Cornea in Vivo Completed NCT00050466
50 Corneal Densitometry Changes With Adenoviral Keratoconjunctivitis Sub Epithelial Infiltrates Completed NCT04267991 Tacrolimus ointment

Search NIH Clinical Center for Corneal Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


deferoxamine mesylate

Cochrane evidence based reviews: corneal diseases

Sources

Genetic Tests for Corneal Disease

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Anatomical Context for Corneal Disease

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MalaCards organs/tissues related to Corneal Disease:

40
Eye, Endothelial, Testes, T Cells, Neutrophil, Skin, Bone
Sources

Publications for Corneal Disease

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Articles related to Corneal Disease:

(show top 50) (show all 1798)
# Title Authors PMID Year
1
COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic. 42
32375197 2020
2
Fibrocytes, Wound Healing, and Corneal Fibrosis. 42
32084275 2020
3
Obstructive Sleep Apnea and Keratoconus: A Systematic Review and Meta-analysis. 42
31895272 2020
4
Anterior segment dysgenesis after overexpression of transforming growth factor-beta-induced gene, beta igh3, in the mouse eye. 54 61
17982418 2007
5
Expression of Sp1 and KLF6 in the developing human cornea. 54 61
17893646 2007
6
Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene. 61 54
17653042 2007
7
[Autosomal dominant granular corneal dystrophy caused by a TGFBI gene mutation in a Mexican family]. 61 54
16888689 2006
8
Keratoepithelin in secondary corneal amyloidosis. 54 61
16331487 2006
9
Proteome profiling of corneal epithelium and identification of marker proteins for keratoconus, a pilot study. 61 54
16083875 2006
10
Influence of interleukin-1alpha and tumor necrosis factor-alpha production on corneal graft survival. 61 54
16489698 2006
11
The molecular genetics of the corneal dystrophies--current status. 61 54
12700042 2003
12
Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. 54 61
12140204 2002
13
Cell density regulated expression of transcription factor Sp1 in corneal stromal cultures. 54 61
11428859 2001
14
Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas. 54 61
10752942 2000
15
Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study. 54 61
8776562 1996
16
Population-based assessment of visual impairment and pattern of corneal disease: results from the CORE (Corneal Opacity Rural Epidemiological) study. 61
31628205 2020
17
Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas. 61
32345752 2020
18
Optimizing outcomes for keratoplasty in ectatic corneal disease. 61
32412957 2020
19
Techniques of noncircular corneal transplantation. 61
32412959 2020
20
Artificial intelligence in cornea, refractive, and cataract surgery. 61
32487811 2020
21
Corneal Blindness in Asia: A Systematic Review and Meta-Analysis to Identify Challenges and Opportunities. 61
32501834 2020
22
Use of white light in vivo confocal microscopy for the detection of spatial changes in the corneal nerves in cases of early-stage Acanthamoeba keratitis with radial keratoneuritis. 61
32461430 2020
23
FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway. 61
32272397 2020
24
Intrastromal Gene Therapy Prevents and Reverses Advanced Corneal Clouding in a Canine Model of Mucopolysaccharidosis I. 61
32330426 2020
25
Toxicity and mechanism of mesoporous silica nanoparticles in eyes. 61
32567638 2020
26
Relationship between optic disc hemorrhage and corneal hysteresis. 61
31879066 2020
27
In silico and in vitro analysis of cation-activated potassium channels in human corneal endothelial cells. 61
32561484 2020
28
Characterising keratometry in different dog breeds using an automatic handheld keratometer. 61
32123011 2020
29
Tear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea. 61
32443005 2020
30
Pediatric Microbial Keratitis: Experience From Tertiary Referral Centers in New South Wales, Australia. 61
32427646 2020
31
mRNA profiling reveals response regulators of decreased fungal keratitis symptoms in a tree shrew model. 61
32057930 2020
32
Preliminary report of postoperative complications of phacoemulsification in Pugs: A multicenter retrospective study of 32 cases. 61
32162486 2020
33
Prevalence and causes of vision loss in East Asia in 2015: magnitude, temporal trends and projections. 61
31462416 2020
34
Visual rehabilitation of patients with corneal diseases. 61
32375800 2020
35
Corneal confocal microscopy: ready for prime time. 61
30834591 2020
36
A Systematic Review on Cornea Epithelial-Stromal Homeostasis. 61
32474566 2020
37
A scientometric analysis of literature published in Indian Journal of Ophthalmology from 2005 to 2017. 61
32317438 2020
38
HSV-1 infection and pathogenesis in the tree shrew eye following corneal inoculation. 61
32301037 2020
39
Paecilomyces/Purpureocillium keratitis: A consecutive study with a case series and literature review. 61
31204788 2020
40
Etiology and Risk Factors for Infectious Keratitis in South Texas. 61
32308946 2020
41
Comparative effects of various types of toric intraocular lenses on astigmatism correction. 61
32345260 2020
42
Interactions between ocular and systemic disease using national register-based data in the Danish Excellence Centre in Ophthalmic Epidemiology (DECODE-EYE): study perspective. 61
32248635 2020
43
Cell-Type-Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium. 61
32197114 2020
44
Canine Corneal Stromal Cells Have Multipotent Mesenchymal Stromal Cell Properties In Vitro. 61
31973649 2020
45
Studies on bacterial cellulose/poly(vinyl alcohol) hydrogel composites as tissue-engineered corneal stroma. 61
31715589 2020
46
Pachymeter Use and Disinfection Practice in the United Kingdom (UK): A National Survey. 61
32341320 2020
47
Evidence of autophagic vesicles in a patient with Lisch corneal dystrophy. 61
32159595 2020
48
[Osteo-odonto-keratoprosthesis: a tooth to regain sight]. 61
32157841 2020
49
Delivery of Antisense Oligonucleotides to the Cornea. 61
32202944 2020
50
The supraorbital and supratrochlear nerves for ipsilateral corneal neurotization: anatomical study. 61
32274242 2020
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Variations for Corneal Disease

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Expression for Corneal Disease

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Search GEO for disease gene expression data for Corneal Disease.
Sources

Pathways for Corneal Disease

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Pathways related to Corneal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hypertrophy Model 1
9.92 ZEB1 IL1A
Sources

GO Terms for Corneal Disease

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Cellular components related to Corneal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TGFBI TGFB2 TFF3 NLRP3 NGF LCAT
2 extracellular space GO:0005615 9.28 TGFBI TGFB2 TFF3 NGF LCAT KERA

Biological processes related to Corneal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.02 VSX1 TGFBI KRT12 KERA CRYAA
Sources

Sources for Corneal Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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